Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| specific binding of t lymphocytes to macrophages. v. the role of ia antigens on mphi in the binding. | the effect of anti-ia alloantiserum on the capacity of selected peritoneal exudate lymphocytes (selected pel) to bind to antigen-pulsed f1 (responder x nonresponder) macrophages was investigated. with the use of selected pel for antigens under ir gene control, it was shown that anti-ia serum to the responder haplotype blocked adherence of selected pel to antigen-pulsed macrophages whereas anti-ia serum to the nonresponder haplotype did not. the target cell of the anti-ia alloantiserum appeared t ... | 1979 | 87437 |
| in vitro synthesis of infectious transforming dna by the avian sarcoma virus reverse transcriptase. | infectious dna molecules, capable of transforming chicken embryo fibroblasts, can be synthesized by the rous sarcoma virus-associated reverse transcriptase in vitro. the optimal enzymatic conditions employed for infectious dna synthesis also facilitate maximum synthesis of genome length dna. analysis of the dna product synthesized by detergent-disrupted rous sarcoma virus under these conditions indicates that dna complementary to viral rna (minus-strand dna) is genome length in size, whereas dna ... | 1979 | 85719 |
| treatment of chickenpox pneumonia with adenine arabinoside. | 1979 | 86115 | |
| diisopropylfluorophosphate-evoked inhibition of anaphylactic histamine release from human skin: decrease of the inhibition by storing the skin specimens. | antigen-induced histamine release from human skin slices passively sensitized with reaginic serum in vitro was inhibited by dfp, suggesting involvement of serine esterase activation in the reaction. the magnitude of dfp-evoked inhibition of the histamine release was not the same in each skin sample and no correlationship was observed between the magnitude of the dfp-evoked inhibition of the histamine release and that of the histamine release in the absence of dfp. the magnitude of the histamine ... | 1979 | 84487 |
| quantitative analysis of catecholamines in skin and serum. | a quantitative method for the analysis of noradrenaline and adrenaline by means of high performance liquid chromatography (hplc) and electrochemical detection is described. the method is applicable to tissues as well as serum. | 1979 | 84499 |
| intraepithelial lymphocytes in the excurrent ducts of the testis of the domestic fowl (gallus domesticus). | cells considered to be lymphocytes are reported in the epithelial lining of the excurrent ducts of the testis of normal and vasoligated domestic fowl. they resemble those already reported in the rat and monkey epididymal epithelium, the human intestinal mucosa, and in the bursa of fabricius. the cytoplasm is usually less dense than that of adjacent epithelial cells, and contains only a few organelles. the nucleus is highly heterochromatic and with no definite nucleolus. cytoplasmic processes are ... | 1979 | 84511 |
| pharmacokinetics and tolerability of a single oral 600-mg dose of doxycycline. | the pharmacokinetics of a single orally administered 600-mg dose of doxycycline (six 100-mg film-coated tablets) was studied in 18 healthy subjects. plasma doxycycline levels remained above 1.35 mumol/l for 48 hours and compared favourably with the mean inhibitory concentrations of doxycycline against the common infecting organisms in chronic bronchitis. in a separate tolerability study in 37 healthy subjects, there was no significant difference between doxycycline and placebo in the incidence o ... | 1979 | 38382 |
| detection of experimental bacteremia and fungemia by examination of buffy coat prepared by a micromethod. | rabbits received intravenous injections of bacteria or fungi, and a comparison was made of the abilities of broth cultures, plating after dilution either in saline solution or in distilled water containing triton x-100, and buffy coat examinations to detect the organisms in heart blood. the most sensitive method was broth culture. by microscopy or subculture of buffy coat cells prepared by centrifugation of blood in microhematocrit tubes, organisms were rapidly and regularly detected when their ... | 1979 | 38662 |
| bactericidal and bacteriostatic action of chloramphenicol against memingeal pathogens. | the bacteriostatic and bactericidal effects of chloramphenicol, ampicillin, tetracycline, and sulfisoxazole were compared against several potential meningeal pathogens. chloramphenicol is bactericidal at clinically achievable concentrations against haemophilus influenzae, streptococcus pneumoniae, and neisseria meningitidis. it is bacteriostatic against gram-negative bacilli of the family enterobacteriaceae and against staphylococcus aureus. chloramphenicol has proven highly efficacious in the t ... | 1979 | 38742 |
| [antibiotics therapy in chronic bronchitis]. | in chronic bronchitis antibiotic therapy is no causative therapy, because infection rarely is the beginning but the complication of an already existing airway disease. while sputum cultures are very limited in their value, blind chemotherapy of bacterial infections by substances like tetracycline, ampicilline, azidocilline or cotrimoxazole is allowed. in cases of additional obstruction a combination with corticosteroids sometimes may be useful. | 1979 | 39882 |
| use and efficacy of pneumococcal vaccine in patients with hodgkin disease. | fulminant bacterial sepsis has been described in patients with hodgkin disease who have undergone splenectomy for staging purposes. the organisms commonly associated with sepsis in this setting include streptococcus pneumoniae and haemophilus influenzae. polyvalent pneumococcal vaccine (merck) has recently been licensed and has been suggested for use in patients with hodgkin disease who are at risk for postsplenectomy sepsis. we administered 14-valent pneumococcal vaccine to 24 patients with hod ... | 1979 | 40635 |
| pathogenic species of the genus haemophilus and streptococcus pneumoniae produce immunoglobulin a1 protease. | thirty-seven strains of the genus haemophilus and five strains of streptococcus pneumoniae were examined for their ability to produce extracellular enzyme that cleaves immunoglobulin molecules. all strains of h. influenzae, h. aegyptius, and s. pneumoniae elaborated enzyme that selectively cleaved human immunoglobulin a1 (iga1) myeloma proteins but was inactive against a variety of other proteins including human iga2, igg, and igm, porcine and bovine secretory iga, human and bovine serum albumin ... | 1979 | 40878 |
| bacterial adherence to pharyngeal cells in smokers, nonsmokers, and chronic bronchitics. | selective adherence to host mucosal surfaces is probably a requirement for colonization and infection by bacteria. since pharyngeal colonization may be an important determinant in the pathogenesis of pneumonia, we studied the adherence of 10 different bacteria to pharyngeal cells obtained from nonsmokers, smokers, and chronic bronchitics. various patterns of adherence among the different groups of subjects were found. young healthy smokers had increased adherence of streptococcus pneumoniae type ... | 1979 | 40879 |
| immunoglobulin a1 protease production by haemophilus influenzae and streptococcus pneumoniae. | bacterial strains of haemophilus species and streptococcus pneumoniae were examined for synthesis of the enzyme immunoglobulin a1 (iga1) protease. of 36 h. influenzae strains examined, 35 produced iga1 protease; strains included all six capsular types, unencapsulated variants of types b and d, and untypable h. influenzae. eight haemophilus strains (non-h. influenzae) were studied, and two produced iga1 protease. all 10 strains of s. pneumoniae produced iga1 protease; these strains included 9 dif ... | 1979 | 40880 |
| [a bacteriological investigation of acute purulent otitis media (author's transl)]. | 1979 | 41035 | |
| [range and possibilities of treatment of chronic bronchitis and its complications]. | 1979 | 41227 | |
| [culture and morphological characteristics of haemophilus influenzae and pneumococcus in bronchial infection]. | in the cultures obtained by inoculating sputum samples faken from patients with bronchial infection into solid agar medium prepared on hottinger's hydrolysate with fresh rabbit blood added haemophilus influenzae produced colonies varying in their from (dome-shaped, conical, trapeziform), as well as in the morphology of the organisms. pneumococci produced mainly flat colonies surrounded by the zone of alpha hemolysis. along-side with isolated h. influenzae and pneumococcal colonies, symbiotic col ... | 1979 | 41387 |
| [bacterial coincidence in the infected middle ear and nasopharynx (author's transl)]. | 1979 | 41890 | |
| [action of aortic cathepsin d on serum low-density lipoproteins]. | action of aortic cathepsin d on low density lipoproteins /ldl/ from human serum was studied by means of analytical ultracentrifugation. cathepsin d intensively hydrolysed ldl, leading to decrease in the sedimentation coefficients of the product formed. the product of degradation of ldl possessing a sedimentation coefficient of 4.5 s /in 0,04 m kbr; 0,042 m nacl, 2 mm edta, 6 mm tris, ph 7.3 /contained apparently the minimal amount of proteins, which could still maintain the stability of partiall ... | 1979 | 42218 |
| should we plan a general childhood vaccination against bacterial meningitis? | an estimation of the benefits of vaccination against bacterial meningitis are based on the age-specific incidence of meningitis caused by the different groups of meningococci, by haemophilus influenzae and by pneumococci, and the known efficacy of the present polysaccharide vaccines against these agents. since the incidence of bacterial meningitis is more than ten times higher below the age of five years that at a later age, vaccination at 1 1/2 years of age could prevent a large fraction of all ... | 1979 | 42596 |
| an evaluation of 12 methods for the demonstration of penicillinase. | twelve methods for the demonstration of bacterial penicillinase production by strains of haemophilus influenzae and staphylococcus aureus are compared, and their suitability for routine clinical laboratory use is evaluated. the acidometric agar plate method is recommended. | 1979 | 42650 |
| [the bacteriological diagnosis of pneumonia by transtracheal puncture. value in medical intensive care (author's transl)]. | seventy five patients referred with a diagnosis of pneumonia underwent transtracheal puncture. in 76% of cases this examination led to discovery of an organism in infected patients. in 50% of cases, the bacteriological diagnosis was sufficiently accurately oriented by direct examination to permit rapid and effective treatment. there was virtually perfect agreement with the results of blood cultures when the latter were positive. the organisms most often responsible were gram positive and above a ... | 1979 | 42881 |
| opsonic activity of normal human cerebrospinal fluid for selected bacterial species. | the opsonic activity of normal human cerebrospinal fluid (csf) has not been well defined. in this study, the opsonic activity of normal csf for laboratory and blood culture isolates of staphylococcus aureus, streptococcus pneumoniae, escherichia coli, hemophilus influenzae type b, and neisseria meningitidis was measured by a quantitative assay employing radiolabeled bacteria and polymorphonuclear leukocytes. all isolates of s. aureus, except the wood 46 strain, were opsonized in undiluted csf (> ... | 1979 | 43289 |
| comparative immunogenicity of group 6 pneumococcal type 6a(6) and type 6b(26) capsular polysaccharides. | the comparative immunogenicity of the two cross-reacting group 6 pneumococcal capsular polysaccharides, type 6a(6) and type 6b(26), was studied with hyperimmune rabbit typing antisera and with sera from adult volunteers injected with polyvalent pneumococcal vaccines containing either 50 mug of type 6a (u.s. designation, type 6) or 50 mug each of type 6a and type 6b (u.s. designation, type 26) polysaccharides. both group 6 polysaccharides were linear copolymers composed of 1 mol each of d-galacto ... | 1979 | 43290 |
| quantitative sputum gram stains in chronic bronchial disease. | 1979 | 43418 | |
| [bacteria isolated from cerebrospinal fluid specimens in gothenburg during a 5-year period]. | 1979 | 43439 | |
| unsuspected bacteremia in young children: a common and important problem. | 1979 | 43959 | |
| serotypes of streptococcus pneumoniae causing disease. | serotypes of streptococcus pneumoniae from 525 infected children were examined over a four-year period. type distribution was similar among 84 cases of bacteremia and 30 cases of meningitis, with types 6, 14, and 18 accounting for half of the illnesses. in contrast, half of 396 episodes of otitis media were caused by three other types, 19, 23, and 3. four of eight fatalities were due to type 6. carrier strains isolated from children had a distribution of types similar to that of the otitis media ... | 1979 | 44310 |
| [epidemiologic features of pneumococcal meningitis in africa. clinical and serotypical aspects (author's transl)]. | pneumococcal meningitis, because of their frequency and their severity, are regarded as an important problem of public health in africa. in a great number of african countries, particularly equatorial and central africa, the pneumococcus is the first agent of bacterial meningitis. the annual prevalence is estimated as about 14/100 000 persons. the case fatality rate (on 1 600 cases) is 49,5% ; the annual mortality reaches about 7/100 000 (28 000 annual deaths in africa). the babies and the old p ... | 1979 | 44737 |
| comparative study of erythromycin, amoxicillin and ampicillin antimicrobial activity against human respiratory tract pathogens. | an in vitro test system was used to compare the antimicrobial activity of erythromycin, amoxicillin and ampicillin against respiratory tract pathogens isolated from man. the minimum inhibitory concentrations (mics) of fresh clinical isolates of streptoccus pyogenes, streptocuccus pneumoniae, staphylococcus aureus and haemophilus influenzae to the macrolide and penicillins ranged between 0.01 and 0.9 microgram/ml. the microbes were exposed to each antibiotic for approximately 3 h at 1x,2x and 5x ... | 1979 | 44765 |
| [animal experiments with combined local immunization against an influenza virus disease (author's transl)]. | 1979 | 44774 | |
| evaluation of cefaclor and amoxycillin in the treatment of acute otitis media. | twenty-eight patients with acute otitis media were treated in a random double blind manner with either amoxycillin or cefaclor. the predominant organisms isolated were h. influenzae and s. pneumoniae. all patients responded satisfactorily except one, treated with cefaclor, whose compliance with the regimen was very doubtful. one instance of mild elevation of sgot and one case of mild erythematous rash occurred in each treatment group. in this limited study, cefaclor appeared comparable to amoxyc ... | 1979 | 44907 |
| treatment of acute bacterial bronchitis and pneumonia with cefaclor. | sixty patients with pneumonia and/or bronchitis were treated with cefaclor, a new orally administered cephalosporin. of those 60, 27 adults were treated with 500 mg every 8 hours, 26 adults with 250 mg every 6 hours, and 7 children with 50 mg/kg/day. in the adults, pneumonia was caused most frequently by streptococcus pneumoniae and haemophilus influenzae. the 7 children had pneumococcal pneumonia. all but 2 adults, both elderly patients with chronic obstructive pulmonary disease, were successfu ... | 1979 | 44908 |
| comparative in vitro microbiological activity and stability of cefaclor. | the in vitro activity of cefaclor was compared with that of cephalexin and cephradine. this new antibiotic was the most active of the oral agents against haemophilus influenzae (especially non-beta-lactamase producing strains). it was also significantly more active against n. gonorrhoeae and the enterobacteriaceae. the instability in agar raises some issues that need further study. | 1979 | 44910 |
| [in vitro activity of cefaclor (author's transl)]. | a comparative study was conducted on the in vitro activity of cefaclor and other oral cephalosporins against a large number of freshly isolated clinical strains of gram-negative and gram-positive bacteria. the activity of cefaclor against gram-positive pathogens is very similar to that of cephalexin. the action of cefaclor against streptococcus pneumoniae is superior. cefaclor is the most active antibiotic against strains of haemophilus influenzae, and is also more active than cephalexin and cep ... | 1979 | 45087 |
| emergence of antibiotic resistance in hospitals, 1935-1975. | a limited review of the changes in susceptibility of common bacterial pathogens to available antibacterial agents is presented. significant developments in recent years include the following: (1) the emergence of streptococcus pneumoniae with decreased resistance to penicillin and of some strains resistant to several antibiotics; (2) a decline in prevalence of multi-drug-resistant staphylococcus aureus after 1960 following their increasing prevalence in the preceding years (these changes were me ... | 1979 | 45521 |
| diagnosis and treatment: drugs five years later. amoxicillin. | amoxicillin is an aminopenicillin available in the united states only for oral use. it has an antibacterial activity and spectrum similar to that of ampicillin and is destroyed by gram-positive and gram-negative beta-lactamases. it is more active against enterococci and salmonellae than ampicillin, but less active against shigella. it is better absorbed than ampicillin from the gastrointestinal tract with blood levels two to two and one half times those of ampicillin. amoxicillin is an excellent ... | 1979 | 34342 |
| [phenomenon of parental resistance and its genetic regulation]. | lymphocytes of mice f1 (cba x m523) and f1 (a x m523) transplanted to 1000 r irradiated cba or a mice responded to the test antigens--srbc or s. typhi vi-antigen--by formation of 100--1000 times less antibody forming cells than in syngeneic recipients. an intermediate result is achieved when the lymphoid cells are transplanted to the irradiated m523 mice. lymphocytes of mice f1 (a x cba), f1 (cba x c57bl/6), or f1 (a x a.ca) developed a similar immune response in the irradiated syngeneic mice an ... | 1979 | 34452 |
| electron microscopic studies of serially sectioned cat spinal alpha-motoneurons. i. effects of microelectrode impalement and intracellular staining with the fluorescent dye "procion yellow". | cat spinal alpha-motoneurons were studied in the light and electron microscope after intracellular recording and staining with the fluorescent dye procion yellow. generally, the ultrastructural preservation of the stained neurons improved when the amount of dye delivered was decreased, and when the duration of the microelectrode impalement of the neuron as well as the time between the intracellular staining and the tissue fixation was kept as short as possible. utilizing the optimal experimental ... | 1979 | 84820 |
| food allergy. | 1979 | 84902 | |
| enteritis necroticans in nepal. | 1979 | 84938 | |
| pathogenic entamoeba histolytica. | 1979 | 84952 | |
| staining of legionella pneumophila. | 1979 | 85128 | |
| in vitro sensitization of human t lymphocytes to hapten (tnp)-conjugated and non-treated autologous cells is restricted by self-hla-d. | by co-culturing human t lymphocytes with tnp-treated autologous b lymphocytes and macrophages for 10 days in vitro, sensitization to tnp-treated autologous cells could be detected in a proliferative assay. by restimulation with different types of allogeneic cells and with cells from donors compatible or incompatible for the hla-abc or -d determinants, results were obtained suggesting that the tnp-specific response was restricted by the hla-d but not the -abc antigens of the autologous priming ce ... | 1979 | 85334 |
| goitrogens. | 1979 | 85506 | |
| [relationship of the structure of specific somatic antigen polysaccharides in shigella dysenteriae bacteriae to the immunochemical properties]. | 1979 | 85516 | |
| scotochromogen infection in hairy-cell leukaemia. | 1979 | 84118 | |
| growth-stimulating factor in regenerating canine liver. | extracts from dog livers which had been regenerating for 24, 48, and 72 h after hepatectomy were infused for 6 h into the left portal vein of animals which had fresh portacaval shunts (eck fistula) and which were killed 2 and 3 days later. the brief exposure to the 48-h and especially the 72-h regenerating liver extracts induced a delayed proliferative response predominantly in the left liver lobes, with a slight spillover effect to the right liver lobes but none to the kidney. the response reac ... | 1979 | 84151 |
| association between immunoglobulin allotypes and immune responses to haemophilus influenzae and meningococcus polysaccharides. | serum samples were collected from 20 healthy white and 33 black infants before and after immunisation with three doses of diphtheria-pertussis-tetanus vaccine and with one dose of haemophilus influenzae type b polyribose phosphate vaccine and meningococcal group a and group c polysaccharide vaccines. antibodies to these immunogens were measured and sera were allotyped for several gm, a2m, and km antigens. a highly significant association was found between the km(1) allotype and the immune respon ... | 1979 | 84209 |
| comparison of counterimmunoelectrophoresis and elisa for diagnosis of bacterial meningitis. | 1979 | 84221 | |
| natural plant enzyme inhibitors: part vii--alpha amylase inhibitors & amylases in plant tubers. | 1979 | 94300 | |
| priming increases the amount of interferon mrna in poly(ri).poly(rc)-treated l cells. | priming by mouse interferon pre-treatment resulted in an accumulation of interferon mrna in poly(ri).poly(rc)-treated l cells, starting early in the period of interferon synthesis. on electrophoresis, the priming activity of an interferon preparation co-migrated with the antiviral activity, which suggests identity of the functional principle(s) for these activities. | 1979 | 94345 |
| hepatitis b viral dna molecules have cohesive ends. | hepatitis b virus dna made fully double stranded by a virion dna polymerase reaction could be converted from circular to linear molecules by heating in 10 mm nacl at 77 degrees c or in 100 mm nacl at 90 degrees c for 15 min. heat-generated linear hepatitis b virus dna was reannealed to circular molecules by incubating in higher salt concentrations. the identity of the molecular forms was established by their electrophoretic mobility and appearance in electron micrographs. recircularization was b ... | 1979 | 94358 |
| pheasant virus dna polymerase is related to avian leukosis virus dna polymerase at the active site. | the dna polymerase from amherst pheasant virus (apv), a member of the pheasant virus species of retroviruses, was compared to the dna polymerases of avian leukosis viruses (alv) and a reticuloendotheliosis virus (spleen necrosis virus (snv)). immunoglobulin inhibition tests and competition immunoassays showed that apv and alv dna polymerases are closely related at their active sites. the determinants common to their active sites are not shared by snv dna polymerase. bu using a species-specific r ... | 1979 | 94361 |
| comparison of cardiovascular actions of dihydralazine, phentolamine, and prazosin in spontaneously hypertensive rats. | 1979 | 94378 | |
| effects of phenytoin on refractoriness and conduction in the human heart. | using his bundle electrograms and the atrial (a2) and ventricular extrastimulus (v2) techniques, anterograde and retrograde refractory period studies were performed (in 9 and 12 patients, respectively) before and 10 min after intravenous infusion of phenytoin (dph; mean plasma level, 17.3 micrograms/ml). dph had no effect on the duration of the qrs complex or the h-v interval of the sinus beats; it had variable but insignificant effects on the sinus rates and the atrial, a-v nodal, and ventricul ... | 1979 | 94379 |
| methylprednisolone sodium succinate treatment in global ischemia of the cat isolated heart. | effects of methylprednisolone were studied on isolated, blood-perfused cat hearts subjected to 1 hr of normothermic ischemic arrest. untreated hearts sustained decreases in peak ventricular pressure pulse, dp/dt, and ventricular compliance. ischemic hearts also became edematous, gained sodium, and lost potassium and creatine kinase enzyme activity. steroid treatment did not significantly alter any of these ischemia-induced changes. methylprednisolone treatment did increase resting coronary flow ... | 1979 | 94382 |
| hemodynamic consequences of administration of phentolamine or nitroprusside with dopamine in the dog. | dopamine was administered intravenously to two groups of anesthetized dogs at rates of 2.5, 5, 10 and 20 micrograms/kg/min. after the 20 micrograms/kg/min infusion, mean arterial pressure, heart rate, renal blood flow, mean pulmonary arterial pressure, and left ventricular filling pressure were increased. the dopamine infusion was continued in both groups of animals. in group i phentolamine was administered at rates of 2.5, 5, and 7.5 micrograms/kg/min; in group ii sodium nitroprusside at rates ... | 1979 | 94404 |
| effects of etafenone and antiarrhythmic drugs on na and ca channels of guinea pig atrial muscle. | since ca-mediated electrophysiological phenomena seem to be important in the generation of various arrhythmias, we quantitatively compared the effects of quinidine, disopyramide, procainamide, lidocaine, propranolol, and etafenone, a new coronary vasodilator with antiarrhythmic properties, on na and ca channels in normal and depolarized guinea pig atria. the maximum rate of rise of the normal action potential and the amplitude of the depolarized, ca-mediated action potential were measured to exa ... | 1979 | 94412 |
| axonal transport. | 1979 | 94473 | |
| studies on the nature of the type specific antigen of erysipelothrix rhusiopathiae. | 1979 | 94508 | |
| fanconi's anemia: the preanemic phase. | anticipation of franconi's anemia prior to the development of overt marrow aplasia may prevent some morbidity and mortality from infectious and hemorrhagic complications. a presumptive diagnosis was made in a firstborn child and radial anomalies, small size, elevated fetal hemoglobin, intermittent excessive chromosome breakage and elevated t-antigen expression in fibroblasts infected with simian virus 40. serial studies may help identify infants and young children at risk to develop this type of ... | 1979 | 94509 |
| inhibition of rat pancreatic secretion by neurotensin: mechanism of action. | the effect of neurotensin on rat pancreatic secretion was studied in the conscious animal as well as on pancreatic lobules. in vivo neurotensin induced a dose-related inhibition of both water and protein basal secretion. protein secretion was much more depressed than fluid secretion. neurotensin did not modify the pancreatic response to exogenous secretin or cholecystokinin-pancreozymin, or to intraduodenal infusion of hcl. on the other hand neurotensin totally inhibited the increase in volume a ... | 1979 | 94530 |
| potentiation and inhibition of ganglionic transmission by ruthenium red. | the effect of ruthenium red, 2.5 to 5 mum, on ganglionic transmission in rat superior cervical ganglia and frog abdominal ganglia were studied in vitro. in rat ganglia, ruthenium red caused a spontaneous firing of ganglia cells, and an increase in the amplitude and duration of the compound action potential following a single stimulus volley. however, transmission following a conditioning volley or a repetitive stimulus train to the preganglionic nerve was depressed up to 60 sec. the asynchronous ... | 1979 | 94531 |
| resolution of human fibroblast interferon into two distinct classes by thiol exchange chromatography. | chromatography of crude and purified human fibroblast interferon on activated thiol sepharose 4b yielded two classes of material exhibiting different stability to inactivation by mechanical stress. interferon which bound to the gel accounted for 20--30 per cent of recoverable activity, could be eluted with reducing agents and was unstable. unbound material did not bind on subsequent rechromatography and was stable to shear forces. leucocyte interferon did not bind, nor did fibroblast interferon ... | 1979 | 94537 |
| the search for infectious viral dna in human leukemic cells. | 1979 | 94579 | |
| cellular and virological studies directed to the pathogenesis of the human myelogenous leukemias. | 1. work over the past years and especially results of the past few years indicate that type-c viral or viral related genetic information exists in humans. 2. we do not know how this information entered humans or whether it causes disease, but it is of interest that the probes from the viruses used to detect this information are from the very same viruses which we find can affect growth and differentiation of some human hematopoietic cells. 3. the status of actual virus isolates from humans, thou ... | 1979 | 94583 |
| hexachlorocyclohexane (technical hch and lindane). | 1979 | 94584 | |
| acute and chronic beta-receptor blockage with propranolol and the cardiovascular responses to intravenous sodium nitroprusside in the conscious rabbit. | sodium nitroprusside infused intravenously into conscious rabbits lowered blood pressure and raised heart rate and plasma noradrenaline. acute beta blockade with propranolol, 2 mg/kg/hr i.v. for 2 hr, increased resting plasma noradrenaline and did not change the hypotensive effects of nitroprusside or the rise in plasma noradrenaline but attenuated the increase in heart rate. chronic treatment with propranolol, 2 mg/kg twice daily for 3 weeks, did not modify the cardiovascular or reflex effects ... | 1979 | 94618 |
| antiarrhythmic and hemodynamic actions of flecainide acetate (r-818) in the ischemic porcine heart. | the antiarrhythmic activity of flecainide acetate (r-818), 2 mg/kg, was investigated in anesthetized, open-chest pigs. ventricular arrhythmias were provoked by reducing the flow in the left anterior descending coronary artery (lad) to 25% of control during 30 min. during this period ventricular fibrillation occurred in 33% (11 out of 33) of control animals against 12.5% (1 out of 8) of animals treated with flecainide. ventricular tachycardias were seen in 42% (14 out of 33) of the untreated anim ... | 1979 | 94625 |
| studies on the role of vasopressin in blood pressure control of spontaneously hypertensive rats with established hypertension (shr, stroke-prone strain). | we investigated the role of arginine-vasopressin (avp) in maintaining the blood pressure of spontaneously hypertensive (sh) rats (stroke-prone strain) with established hypertension (22--28 weeks of age). in comparison with normotensive wistar kyoto (wky) rats, plasma avp concentrations of sh rats with benign hypertension (bh) were elevated twofold and in rats with severe or malignant hypertension (s-mh), fourfold. the height of the blood pressure was quantitatively related to plasma avp in both ... | 1979 | 94626 |
| thyroxine and propylthiouracil effects on alpha- and beta-adrenergic receptor number, atpase activities, and sialic acid content of rat cardiac membrane vesicles. | 1979 | 94627 | |
| concentration dependence of the binding of ouabain to isolated guinea pig atria. | 1979 | 94634 | |
| neutral protease activity in lymphocytes of lewis rats with acute experimental allergic encephalomyelitis. | lymphocytes from popliteal and inguinal lymph nodes of lewis rats with acute eae as a result of injection of lyophilized guinea pig myelin in freund's complete adjuvant exerted strong proteolytic activity at neutral ph toward myelin basic protein. after injection of myelin the level of proteolytic activity remained about the same as that in lymphocytes from freund's adjuvant-injected controls until about day 10 after injection, just before the onset of paralytic symptoms; then the proteolytic ac ... | 1979 | 94652 |
| regulation of expression of type c virion dna polymerase (reverse transcriptase) in human x mouse and human x rat hybrid cells. | human cells from 13 different individuals were fused to mouse and rat cells producing abundant type c viral particles. the results demonstrate that incorporation of active dna polymerase (reverse transcriptase) into mature type c particles is suppressed in many of the hybrid clones but not in the parental mouse cell clones. this low particle-associated dna polymerase phenotype was a heritable trait for over 100 cell generations but reversion to a high particle-associated dna polymerase phenotype ... | 1979 | 94700 |
| false negative hla-dr assignment necrokidney donors. a glucocorticoid effect? | thirteen potential necrokidney donors were hla-dr typed using peripheral blood b lymphocytes (pbbl). antigen assignment was impossible in 10 cases because of non-reactivity of the pbbl with the hla-dr testserum set, in some of the cases in spite of positive reactions with a positive control xenogeneic anti-human b cell antiserum. in five of these 10 donors, hla-dr typing was also performed on b lymphocytes isolated from the spleens, and in all five cases strong specific reactions were obtained, ... | 1979 | 94708 |
| transferable drug resistance of escherichia coli isolated from infant diarrhoea. | the resistance to several drugs was determined in 29 pathogenic strains of escherichia coli (026, 055 and 0111) isolated from infant diarrhoea and 18 non-pathogenic e. coli strains isolated from the same individuals. both pathogenic and nonpathogenic strains were resistant to at least 1 to 10 drugs, but only in four cases resistance patterns of the pathogenic strains were identical with those of non pathogenic ones. the majority of the strains were resistant to sulfonamide, tetracycline, ampicil ... | 1979 | 94745 |
| determination of metabolite compartition in hepatic cells by varying the redox state in vivo. | in the present study, metabolite (lactate, pyruvate, glycerol 3-phosphate, dihydroxyacetone phosphate) concentrations were measured in various redox states. the mathematical relations between metabolite concentrations in various redox states were expressed algebraically and studied. models which provided separate lactate/pyruvate (l/p) and glycerol 3-phosphate/dihydroxyacetone phosphate (g/d) spaces correspond to the experimental results in the case of "reductants" (e.g. ethanol, acetaldehyde, d ... | 1979 | 94822 |
| effect of beta-blockers on sodium and potassium content of human erythrocytes. | recently, hyperpotassemia was reported in patients treated with propranolol, but the mechanism has not yet been delineated. we have investigated the effects of various beta-adrenergic blockers and of d-propranolol on the na+ and k+ distribution intra- and extracellularly in human erythrocytes. k+ loss and na+ gain by cells was demonstrated at drug concentrations of 10(-4) m or greater. d-propranolol was more effective than l-propranolol, whereas pindolol was ineffective. practolol increased na+ ... | 1979 | 94824 |
| a research on the action of testosterone propionate and of ciproterone acetate on the mouse-killing behaviour of the adult rat. | data demonstrate exactly that testosterone favour above all the killing behaviour of castrate males at birth in comparison with control males while ciproterone acetate turns out to be more effective in diminishing the killing behaviour of males having integral testicle and of androgenized females at birth in comparison with castrated males. the results point out that the killing behaviour of rats is affected by the presence of testosterone in the first days of life, and in the grown-up animal. | 1979 | 94826 |
| antigenic homology of feline and human beta-hexosaminidase. | the immunological characteristics of feline beta-hexosaminidase (beta-d-n-acetylglucosaminidase, ec 3.2.1.30) isoenzymes, hex a and hex b, were studied. immunization of rabbits and goats with either cat hex a or hex b produced antibodies which reacted with a common antigenic marker shared by both hex a and hex b. with properly absorbed antisera, a unique antigenic marker was demonstrated on cat hex a, but not on hex b. this antigenic profile is comparable to that of the human beta-hexosaminidase ... | 1979 | 94833 |
| [effects of different concentrations of chloramphenicol on rna synthesis in e. coli]. | in the presence of 2 microgram/ml chloramphenicol the rate of total rna synthesis increases 1,6-fold, while that of rrna synthesis--2,5--3,0-fold. other ribosomal antibiotics, e.g. oxytetracycline, neomycin and puromycin, as well as chloramphenicol stimulate the synthesis of rna while not causing a complete inhibition of the protein synthesis. intensive stimulation of the rate of rrna synthesis with low concentrations of chloramphenicol may be due to a decrease of intracellular concentration of ... | 1979 | 94838 |
| [immunosuppressive activity of variously prepared alpha-globulin fractions of human blood]. | 1979 | 94844 | |
| [faecal enzyme diagnostic (author's transl)]. | the hitherto existing results of determinations of enzymatic activities in stool are presented in this review. the chymotrypsin activity is diminished in advanced exocrine pancreatic insufficiency. the faecal alpha-amylase activity has up to now no significance in the diagnosis of pancreatic diseases. up to five amylolytic enzyme activities are detectable. the alkaline phosphatase is mostly of intestinal origin. up to 4 enzyme bands can be exhibited with the disc electrophoresis in polyacrylamid ... | 1979 | 94852 |
| the effect of glutaurine on the development of amphibian larvae with inhibited rna and protein synthesis. | 1. glutaurine (gamma-l-glutamyl-taurine) isolated from bovine parathyroid and later synthetized retards the metamorphosis of rana arvalis. 2. from day 13 of treatment glutaurine moderates the metamorphosis inhibiting effect of antibiotics acting at the transcription and translation level. | 1979 | 94855 |
| [effect of ergoline derivatives on platelet and blood vessels]. | the influence of dihydrogenated ergot alkaloids on vessels and blood platelets was studied in vitro and in vivo. at low concentrations they cause contraction of isolated vein strips via a stimulation of alpha-adrenoceptors, at higher concentrations they antagonize the action of noradrenaline on arteries and veins and inhibit the adrenaline-induced platelet aggregation in vitro. in volunteers, intravenous and subcutaneous administration of dihydroergotamine (dihytamin) caused a decrease in blood ... | 1979 | 94864 |
| role of interferon in mice in protection against influenza a virus by bacterial ribosomes together with membranal glycoproteins of klebsiella pneumoniae as adjuvant. | nonspecific protection against infectious aerosols of influenza a virus was obtained in swiss mice after vaccination by aerosols of bacterial ribosomes together with membranal glycoproteins extracted from klebsiella pneumoniae as the adjuvant. it was shown that repeated stimulant aerosols were necessary to obtain this protection. routine estimation of serum interferon levels after administration of the association of ribosomes plus membranal glycoproteins to the animals by aerosol or intravenous ... | 1979 | 94908 |
| rapid isolation of carcinogen-bound dna and rna by hydroxyapatite chromatography. | carcinogen-bound dna and rna are conveniently isolated by solvent extraction and hydroxyapatite (hap) chromatography. tissue is suspended in 8 m urea-0.24 m sodium phosphate-1% sodium dodecyl sulfate-10 mm edta, ph 6.8 (mup-sds-edta) and extracted with chloroform-isoamyl alcohol-phenol (24:1:25; cip) to remove protein. rna and dna are separated by passing the aqueous solution through an hap column; rna is eluted with mup, dna with 0.48 m sodium phosphate, ph 6.8. examples presented are: (1) calf ... | 1979 | 94918 |
| [circadian variations of the plasma proteins in the adult male rat under natural synchronisation (author's transl)]. | circadian rhythms of blood total proteins, albumin, alpha 1-, alpha 2-, beta- and gamma-globulins were documented in 80 wistar spf adult male rats, synchronized by natural light (06.00-18.00 h) and darkness (18.00-06.00 h) during the month of october 78. blood was sampled at four fixed time points in the 24 h scale (i.e. 04.00, 10.00, 16.00 or 24.00 h). total proteins, albumin, alpha 2- and gamma-globulins showed a statistically significant rhythm with a maximum at 04.00 h. the data obtained in ... | 1979 | 94931 |
| electron microscopy of malachite green--glutaraldehyde fixed bacteria. | malachite green combined with glutaraldehyde has been used recently as a fixative for preserving and revaling lipid complexes in thin sections of eukaryotic cells examined by electron microscopy. when bacteria were prefixed with the above mixture granular electron dense inclusions were revealed in all cultures tested. these inclusions were replaced by electron transparent areas in cells fixed with glutaraldehyde alone. the structures were frequently located near to or within the nucleoid and adj ... | 1979 | 94953 |
| [interferon in the anti-influenza protection provided by a mixtures of bacterial ribosomes and a membrane fraction of k. pneumoniae applied as an aerosol]. | 1979 | 94959 | |
| synthetic antigens iii. antigen-binding cells to interpolymer of styrene and maleic acid psm and sheep red blood cells in mice immunized with psm. | studies on the immune response in mice to a new synthetic antigen interpolymer of styrene and maleic acid (psm) are described. the immune response was measured by determination of antigen binding cells by means of rosette test with psm-coated srbc, an unexpected effect was observed--besides rosette-forming cells for psm, rosette-forming cells and agglutinating antibodies for sheep red cells were found. the results presented in this paper suggest that psm is acting both as an immunogen and a poly ... | 1979 | 94989 |
| histochemical studies of mucosubstances and keratins of thymic corpuscles. | keratin and prekeratin have been visualized histochemically by testing the reactivity of disulfide groups in the thymic corpuscles of the sheep. rhesus monkey, rabbit and dog, and the reactivity of sulfhydryl groups in the sheep, rhesus monkey, rabbit and rat. ten to 50% of the thymic corpuscles showed keratinization by this method. acidic mucosubstances were visualized histochemically in the rhesus monkey, sheep and rat but not in the rabbit. staining for vic-glycol groups was prominent in all ... | 1979 | 94996 |
| pulsus alternans in regionally hypoxic ventricles of open-chest dogs: regional mechanical alternation of potentiation and attenuation of the inotropic state. | sustained mechanical alternation appeared after a spontaneous premature ventricular contraction in 6 open-chest dogs during the perfusion of the left circumflex coronary artery by krebs-henseleit solution equilibrated with 5% co2 and 95% n2. the animals were instrumented with a catheter in the left ventricle and ultrasonic crystals in hypoxic and control segments. left ventricular systolic pressure was significantly higher in the strong than in the weak beats with no significant difference of en ... | 1979 | 94997 |
| properties and usefulness of the original k-562 human myelogenous leukemia cell line. | 1979 | 95026 | |
| projections of raphe neurones to the cerebellar vermis cortex in the rabbit. a horseradish peroxidase (hrp) study. | 1979 | 95045 | |
| cerebral manifestations of whipple's disease. | a case of whipple's disease with central nervous system (cns) involvement has been retrospectively diagnosed. at the age of 50 and after six years of recurrent bouts of pyrexia, anorexia and loss of weight, a man developed a subacute encephalitis. two episodes of acute loss of vision were followed by changes in mental status, supranuclear ophthalmoplegia and oculo-facio-cervical myorhythmias which remained present until death, one year later. combined light- and electron microscopic studies have ... | 1979 | 95079 |
| biochemical and immunochemical studies of alpha-amylase from the salivary glands of the mouse. | 1979 | 95093 | |
| tumor immunology in domestic animals. | 1979 | 95155 | |
| [retrospective study in hepatic biopsies, of hepatitis b surface antigen by the orcein method and indirect immunofluorescence methods]. | a retrospective study of the hbsag was done in 56 liver biopsies of children less than 12 year-old and 78 biopsies of adults. the study was performed by orcein stain and indirect immunofluorescent method. in 23 of the adults patients, the serological detection of hbsag and antibodies (hbsab) was determined by reverse passive haemagglutination technique. the adults patients' histological dianosis were variable and included acute or chronic hepatitis (20.5%) and cirrhosis (24.4%). orcein was posit ... | 1979 | 95161 |