Publications

post partum patterns of circulating fsh, lh, prolactin, estradiol, and progesterone in nonsuckling cynomolgus monkeys.	circulating levels of fsh, lh, prolactin (prl), estradiol (e), and progesterone (p) were determined by ria in four intact and four monkeys luteectomized (clx) at parturition in order to a) characterize the patterns of these hormones during the puerperium, and b) examine a possible inhibitory role of the "rejuvenated" corpus luteum (cl) on the resumption of follicle growth post partum. in both groups during the first four weeks, fsh and lh were at tonic levels typical of ovulatory cycles. recurre ...	1978	97808
[sarcocyst resistance to certain factors].		1978	97852
[personal prophylaxis of venereal diseases].		1978	97875
[an index of blood neutrophil injury in man and animals immunized with live anthrax vaccine].	the authors present the results of study of the blood neutrophil injury in guinea pigs, rabbits, monkeys, and also humans inoculated subcutaneously with live anthrax vaccine. along with intradermal test with anthraxin, the mentioned test is suggested to assess the immunological status of persons immunized with anthrax vaccine.	1978	97884
[prospects for the use of blood substitutes made in the ussr with the expired date of validity].	as revealed, blood substitutes--aminopeptide, caseine hydrolysate, and hydrolysine with the expired date of validity could be used as the basis of nutrient media for the cultivation of bacteria. bacterial growth proved to be the optimum in addition to the blood substitutes of a 0.25--0.5% of yeast extract.	1978	97885
post-vasectomy autoimmunity to protamines in relation to the formation of granulomas and sperm agglutinating antibodies.	the development of antibodies reacting with nuclear antigens was studied in sera from vasectomized men and monkeys (obtained at intervals of up to 2 and 4 years, respectively, after the operation), by means of a comparative fluorescence study on swollen nuclei of somatic cells, human and salmon spermatozoa. about 30% of forty-seven vasectomized men developed antibodies to protamines. also four out of fifteen monkeys, vasectomized with or without ligation, developed antibodies reacting with prota ...	1978	102476
high-affinity binding of beta-alanine to cerebral synaptosomes might involve glycine-receptors.	high-affinity, na+-independent binding of beta-alanine to a synaptosomal fraction of rat brain was potently inhibited by glycine and by some other alpha-amino acids, but not by taurine or gaba. this binding mechanism, which was also sensitive to both bicuculline and strychnine, might involve synaptic receptors for both beta-alanine and glycine.	1978	102523
pineal removal or denervation: effects on hypothalamic prf activity in the rat.		1978	102549
ca2+-stimulated phosphorylation of muscle glycogen synthase by phosphorylase b kinase.	phosphorylase b kinase from rabbit muscle phosphorylates glycogen synthase purified from the same tissue. the reaction is markedly stimulated by ca2+ and results in a decrease in the synthase %i activity. phosphorylase b kinase action leads to the incorporation of phosphate (0.6 to 0.8 mol/mol of subunit) preferentially into a single cyanogen bromide fragment of synthase (fragment iii). cyclic amp-independent synthase kinase also shows a specificity for the site(s) contained in fragment iii wher ...	1978	102668
ventricular involvement in experimental hemophilus influenzae meningitis.	we determined the frequency of ventricular involvement during hemophilus influenzae type b meningitis in ten bacteremic infant rhesus monkeys. meningitis was defined as cerebrospinal fluid obtained from the lumbar subarachnoid space or cisterna magna containing bacteria and ten or more leukocytes per mm3. hib were cultured from 22 of 22 ventricular csf samples. in 17 of 18 comparisons of bacterial density in ventricular and cisternal csf, the values were within one log10: similarly, 5 of 8 quant ...	1978	102754
n,n'-(phenylene)dioxamic acids and their esters as antiallergy agents.	a series of dialkyl n,n'-(m-phenylene)dioxamates was synthesized by treatment of the requisite m-phenylenediamines with an alkyloxalyl chloride in the presence of triethylamine. hydrolysis with sodium hydroxide solution gave the corresponding n,n'-(m-phenylene)dioxamic acids. several n,n'-(p-phenylene)dioxamic acids were synthesized also in the same manner starting with the requisite p-phenylenediamines. these compounds were tested in the rat passive cutaneous anaphylaxis (pca) assay. when teste ...	1978	102796
effects of nitroglycerin and dipyridamole on regional myocardial blood flow.	the effects of intravenous administration of nitroglycerin or dipyridamole on distribution of myocardial blood flow in the heart after coronary underperfusion were investigated. in 18 open chest, anesthetized dogs, flow of the tubing supplying the left circumflex coronary artery (lca) was reduced and kept constant, and then the drug was given intravenously. before and after an administration of saline, nitroglycerin (0.04 mg/kg) and dipyridamole (0.2 mg/kg), myocardial blood flow was measured by ...	1978	103535
biochemical genetics of macaques. ii. glucosephosphate isomerase polymorphism in rhesus monkeys.		1978	103539
immunological heterogeneity of haemophilia b: a multicentre study of 98 kindreds.	an electroimmunoassay with a precipitating rabbit anti-human factor ix antiserum and an inhibitor neutralization assay with a non-precipitating homologous antibody were used to measure factor ix antigen (ix:ag) in 117 patients from 98 kindreds with haemophilia b; and to investigate in a mixed population the incidence of different immunological types of the disease. although the two assays showed an excellent correlation, the electroimmunoassay was selected for its simplicity as a criterion for c ...	1978	103564
influence of glycopeptide structure on the regulation of galactosyltransferase activity.		1978	103575
isolation and characterization of a pulmonary glycoprotein from human amniotic fluid.	a glycoprotein of the molecular weight of 36 000 has been isolated from human amniotic fluid. the glycoprotein was found to contain sialic acid, galactose, mannose, fucose, glucosamine, hydroxyproline and relatively high amounts of glycine. end-group analyses resulted in a single nh2-terminal residue indicating that the glycoprotein was homogeneous. the data indicate that this unique collagen-like glycoprotein, which is immunologically identical to a major alveolar glycoprotein found in alveoli ...	1978	103578
effect of immunosuppression on rickettsia rickettsii infection in guinea pigs.	the role of the immune response in the pathogenesis of rickettsia rickettsii infection in guinea pigs was investigated by immunosuppression, using antilymphocyte serum. twenty guinea pigs were inoculated with r. rickettsii, sheila smith strain, on day 0. fifteen animals received antilymphocyte serum on days --1, 0, 2, 4, and 6. five animals received normal rabbit serum on the same schedule. at necropsy, specimens were collected for histological examination, rickettsial immunofluorescence, ricket ...	1978	97223
impaired host resistance to endotoxin and malaria in polychlorinated biphenyl- and hexachlorobenzene-treated mice.	the in vivo effect of polychlorinated biphenyl (pcb) and hexachlorobenzene (hcb) on murine endotoxin sensitivity and resistance to malaria (plasmodium berghei nyu-2) infection was studied. the dietary administration of 167 ppm (167 microgram/g) of pcb 1242 or hcb for 3 weeks resulted in an enhanced sensitivity to gram-negative endotoxin (salmonella typhosa), which was further increased in animals maintained on the diets for 6 weeks. by 6 weeks, a 5.2- or 32-fold increase in endotoxin sensitivity ...	1978	97225
is the solitary dark neuron a manifestation of postmortem trauma to the brain inadequately fixed by perfusion?	dark neurons, classified as solitary because of their sparse occurrence, were discerned in the transitional zones between gray and white matter in various species of laboratory animals fixed by perfusion. these neurons, histologically indistinguishable from dark neurons in immersion fixed material, tended to develop when the saline perfusion was delayed or slow, the amount of the bouin fixative was excessive, or the autopsy was performed shortly after the perfusion. under these conditions, the w ...	1978	97249
ultrastructural study of salmonella typhimurium treated with membrane-active agents: specific reaction dansylchloride with cell envelope components.	amino groups of cell envelope proteins, lipids, and lipopolysaccharides cannot be labeled in intact cells of salmonella typhimurium g 30 by using 5-dimethylaminonaphthalene-1-sulfonylchloride incorporated in lecithin-cholesterol vesicles. however, application of membrane-interacting agents like tris(hydroxymethyl)aminomethane (tris)-hydrochloride, ethylenediaminetetraacetate (na salt) (edta), divalent cations, and sublethal doses of the cationic antibacterial agents polymyxin b and chlorhexidine ...	1978	97268
amino acid sequence of beta-galactosidase. xi. peptide ordering procedures and the complete sequence.	the amino acid sequence of beta-galactosidase has been determined. the monomer contains 1,021 amino acid residues in a single polypeptide chain and has a molecular weight of 116,349. all 80 tryptic peptides as well as all 24 cnbr peptides have been isolated in pure form. evidence is presented for the ordering of the cnbr peptides. the sequence determination was aided by analysis of cyanogen bromide peptides obtained from a polypeptide fragment produced by a lacz termination mutant strain.	1978	97298
characterization of an endoribonuclease, rnase n, from escherichia coli.	the properties of the enzyme ribonuclease n were investigated. by comparing the distribution in the cell of rnase n with the bonafide intracellular beta-galactosidase, and the periplasmic alkaline phosphatase enzymes, we showed that rnase n is an intracellular enzyme. since previous studies suggested that it is an endoribonuclease, it was compared to rnase iii, the only other known intracellular endoribonuclease in escherichia coli. using homopolymers and co-polymers we found that, while rnase i ...	1978	97300
discrepancy between results of the streptozyme test and those of the antideoxyribonulcease b and antihyaluronidase tests.	comparison of the serum titers obtained with the streptozyme, the antistreptolysin o, the antideoxyribonuclease b, and the antistreptohyaluronidase tests suggested that the streptozyme test had failed to detect antibodies against streptococcal deoxyribonuclease b and hyaluronidase. moreover, sera that were negative in the streptozyme test could be shown by immunodiffusion to possess significant numbers of precipitins against extracellular factors produced by group a streptococci. follow-up studi ...	1978	97311
effect of experimentally induced marginal periodontitis and periodontal scaling on the dental pulp.	experimental breakdown of the periodontal attachment apparatus was produced in six young adult monkeys to study the effect on the tissue of the dental pulp by (1) periodontitis, (2) scaling and plaque accumulation on exposed root dentin. periodontal tissue breakdown was induced by the placement of ligatures around the neck of 92 permanent teeth. subsequent plaque formation caused marked loss of periodontal tissue support, which after a period of 5--7 months amounted to 30--40% of the root length ...	1978	97332
isolation and analysis of h-2 and ia alloantigens from wild mouse strains.	immunoprecipitation and sds-page analysis were used to examine h-2 and ia antigens from mouse strains with wild-derived mhc haplotypes. antisera raised against the wild-derived strains contained anti-h-2 and anti-ia antibodies which precipitated antigen molecules readily distinguishable by a single assay procedure. the antibodies to wild strains were cross-reactive with standard laboratory haplotypes. evidence supporting the similar genetic organization of wild and standard haplotypes was found, ...	1978	97344
acquisition of murine major histocompatibility complex gene products by schistosomula of schistosoma mansoni.	schistosoma mansoni schistosomula recovered from the lungs of inbred mice were shown to possess serologically detectable alloantigens on their tegumental surfaces. using appropriate antisera and infected congenic and recombinant mice as worm donors, gene products of the k and i subregions of the major histocompatibility complex were demonstrated among these alloantigens acquired by the parasites. in contrast, other cell surface alloantigens, such as thy 1, ly 1, and h-y and the serum proteins al ...	1978	97360
characterization of the effects of mg2+ on ca2+- and sr2+-activated tension generation of skinned rat cardiac fibers.	submaximum and maximum forces of the cardiac muscle contractile apparatus, activated by ca2+ or sr2+, were determined as a function of mg2+ concentration. apical left ventricular tissue from sprague-dawley rats was broken by homogenization into small bundles of fibers with disrupted sarcolemmas (skinned). tension generation was activated by and graded according to the concentration of ca2+ or sr2+ in solutions bathing the skinned fibers and measured with a photodiode force transducer. steady-sta ...	1978	97362
entry of beta-n-oxalyl-l-alpha,beta-diaminopropionic acid, the lathyrus sativus neurotoxin into the central nervous system of the adult rat, chick and the rhesus monkey.		1978	97367
preliminary x-ray crystallographic data on phospholipase c from bacillus cereus.		1978	97390
effects of ethylenediaminetetraacetic acid-4 sodium solution on the surface of renal calculi and the uroepithelium.	tetrasodium ethylenediaminetetraacetic acid is one of the most effective agents that dissolve renal calculi, especially calculi containing calcium. to study the dissolving process of calculi in solutions, with or without trypsin, serial thin sections of renal calculi composed of calcium oxalate and/or phosphate were prepared and observed by polarizing microscopy. the effects of the solution on the surface of human renal calculi and rat uroepithelium also were studied by scanning electron microsc ...	1978	97399
[results of early nutrition of newborn infants with low birth weight. ii. effects of early nutrition on bilirubin metabolism of newborn infants with birth weights from 1501 to 2000 g].		1978	97464
[transplantation of the big toe from the foot to the hand in monkeys using a microsurgical technic].		1978	97465
effects of pelleting and sterilization of diet on 2 strains of rabbit coccidia.	both autoclaving and irradiation at levels currently used for other laboratory animal diets appear to be satisfactory for the elimination of 2 of the most robust and pathogenic species of rabbit coccidia. pelleting by the usual methods, even at 68 degrees c, was found to be unsatisfactory in eliminating all oocysts from heavily infected diet.	1978	97471
evidence that serotonin neurons stimulate secretion of prolaction releasing factor.		1978	97485
effects of intrahepatic transplantation of pancreatic islets on hepatic metabolism in the rat.		1978	97491
the preparation and use of antibodies as diagnostic biochemical probes.		1978	97493
divalent cation mobility throughout exponential growth and sporulation of bacillus megaterium.	each of the five elements considered was taken up by bacillus megaterium during exponential growth. initial mg and mn uptake was rapid and ended by mid-log. for ca, fe, and zn, uptake continued throughout exponential growth. elements were released from the cells immediately following initial uptake. for mn, egression continued to t2, with release of 36% of total accumulated. secondary uptake followed immediately and continued through stage v. magnesium egression continued to t1 with release of 3 ...	1978	97497
pressure dissociation of bacterial ribosomes and reassociation of ribosomal subunits.		1978	97513
new regulatory mutations affecting the expression of the threonine operon in escherichia coli k-12.	the promoter of the threonine operon was joined to the structural genes of the lac operon in escherichia coli k 12. the synthesis of beta-galactosidase was thus repressed by threonine plus isoleucine in the fusion strains. to isolate mutations which affect the expression of the threonine operon, alterations in the level of expression of the lacz gene were selected. a new type of regulatory mutation was discovered.	1978	97515
effects of learned safety and tolerance on alcohol consumption by the rat.	evidence is presented that learned safety increases the rat's willingness to drink ethanol: induction of tolerance to ethanol following learned safety training produces a further increase. rats with chronically implanted intragastric fistulae consumed substantially more (30%) alcohol when aversive post-ingestional effects were minimized by draining stomach contents during drinking than did rats allowed to retain stomach contents. half the rats from each group were then made tolerant by prolonged ...	1978	97706
the reinforcing property of ethanol in the rhesus monkey ii. some variables related to the maintenance of intravenous ethanol-reinforced responding.		1978	97716
some helminthozoonotic infections in zambia.	parasitic infections constitute an important group of zoonoses. stool examination of inpatients, medical examinees and out-patients in a sub-tropical environment established that inermicapsifer madagascariensis and schistosoma mattheei are occasionally anthropozoonotic in zambia. strongyloides fülleborni, a species normally parasitic in primates is not uncommon in man; whether it is anthropozoonotic or a parasite well adapted to man in this part of africa needs further investigation. the finding ...	1978	97951
comparison of arachnoiditis produced by meglumine iocarmate and metrizamide myelography in an animal model.	myelography in monkeys was performed with either meglumine iocarmate or metrizamide. the severity of resultant arachnoiditis in each animal 12 weeks later was evaluated by repeat myelography and by histologic study of the arachnoid. three of the four animals examined with meglumine iocarmate had severe arachnoiditis; none of the four animals examined with metrizamide had as severe changes. the difference between the two groups was statistically significant (p less than .05).	1978	97964
photoelectric method for estimating hemodynamic changes in regional cerebral tissue.	a new photoelectric method for measuring hemodynamic changes in a thin layer of cerebral tissue in situ is described. the apparatus consists of a miniature lamp of 0.7 mm od and a photodiode with a color filter having maximum light transmission at 548 nm. the lamp was chronically or acutely implanted into the brain tissue of animals as a light source, and the intensity of the light transmitted through the cerebral tissue was monitored with the photodiode from the brain surface. the intensity of ...	1978	98061
effect of staphylococcal enterotoxin b on cardiorenal functions and survival in x-irradiated rhesus macaques.	pretreatment of rhesus macaques with nonlethal total-body x-irradiation (400 r) prolonged survival time from an average of 15 hours to 101 hours after intravenous (iv) inoculation of 50 microgram of staphylococcal enterotoxin b (seb)/kg of body weight. radiation exposure per se did not produce detectable cardiorenal changes; however, the longer survival after seb challenge exposure in x-irradiated rhesus macaques was associated with improved cardiorenal functions if compared with that of nonirra ...	1978	98079
effect of low temperature on growth, viability, and synthesis of mycolic acids of mycobacterium tuberculosis strain h37ra.	cultures of mycobacterium tuberculosis strain h37ra were grownto early logarithmic phase at 37 degrees c and were incubated at 16 degrees, 20 degrees, and 25 degrees c. the decrease in this ability was more rapid at 20 degrees c than at 16 degrees c. low-temperature incubation caused decreases in the ratios of mycolic acids and monounsaturated c16-19 fatty acids relative to the total of fatty acids synthesized. it also caused an increase in the ratio of saturated c24-26 fatty acids relative to ...	1978	98081
microsporidian infection in the cyst wall of trematode metacercariae encysted in fish.	microsporidian infection is reported in liza ramada (risso), mugilidae, from bardawil lagoon, mediterranean coast of sinai, in the fibroblasts of the metacercarial capsule of heterophyes heterophyes (siebold). infection of the metacercarial cyst resulted in an hypertrophy of the cyst wall and degeneration and eventual death of the encapsulated metacercaria.	1978	98090
activity of three 8-hydroxyquinoline derivatives against in vitro dental plaque.	three 8-hydroxyquinoline derivatives, assessed using an in vitro preformed dental plaque model system, were differentially inhibitory for four plaque-forming microorganisms.	1978	98105
in vitro antibacterial activity of amikacin and ticarcillin, alone and in combination, against pseudomonas aerurginosa.	in vitro antimicrobial susceptibility studies using amikacin and ticarcillin, alone and in combination, were performed on 20 strains of pseudomonas aeruginosa. all strains were susceptible to amikacin, and ticarcillin was active against 16 of the 20 strains. enhanced anti-pseudomonas activity could be demonstrated with the combination of amikacin and ticarcillin.	1978	98109
lack of association between human erythrocyte membrane acetylcholinesterase and osmotic fragility.		1978	98168
effects of mosquito control insecticides on nitrogen fixation and growth of blue-green algae in natural plankton associations.		1978	98184
analgetic actions of intrathecal opiates in cat and primate.		1978	98219
cellular uptake, transport, and macromolecular binding of benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene by human cells in vitro.		1978	98231
thyroid-stimulating hormone: neuroregulation and clinical applications. part 2.		1978	98254
relation of nucleosomes to dna sequences.		1978	98278
progesterone levels in monkeys immunized with pr-beta-hcg-tt after injection of hlh and hcg during luteal phase.		1978	98288
the handedness of rhesus monkeys: ii. concurrent reaching.	of 171 monkeys tested for handedness, 60 were found to make occasional bilateral concurrent reaches. these reaches accounted for only 1.3% of the total of 600 reaches observed for each animal. younger animals were observed to make such reaches more frequently than older animals. concurrent reaching was characterized by a lower degree of preference for the overall preferred hand than unilateral reaches made by the same animals at comparable periods of testing.	1978	98292
bacterial endocarditis on a prosthetic valve. oral treatment with amoxicillin.	a patient with endocarditis due to streptococcus faecalis on an aortic valvular prosthesis was successfully treated using large oral doses of amoxicillin concurrently with intramuscular administration of streptomycin. oral therapy was employed because of a persistent reaction to intravenously administered antibiotics. oral therapy for bacterial endocarditis occurring on an artificial valve may be attempted as a last resort when all other accepted therapeutic measures have failed.	1978	98296
filarial nodule of the female breast. clinicopathologic study of 57 cases.		1978	98307
subcortical projections of the dorsomedial visual area (dm) of visual association cortex in the owl monkey, aotus trivirgatus.	the efferent subcortical connections of the dorsomedial cortical visual area (dm) in the owl monkey were determined by tracing degenerating axons following lesions or by tracing axonal pathways following injection of radioactively labeled proline. areas of termination included structures which are known to receive input from many other regions of cortex such as the claustrum, putamen, caudate nucleus, reticular nucleus of the thalamus and pontine nuclei. other terminations were in subcortical st ...	1978	98340
from fallopius to fantasy.	knowledge of the female reproductive system in classical times is reviewed briefly. current knowledge of tubal physiology is explained in greater detail. this knowledge, which is relevant to the study of fertility and sterility, includes sections dealing with: 1) sperm transport; 2) sperm capacitation; 3) fertilization; and 4) ovum and embryo transport. since human data for some of these areas is lacking, data obtained in the study of other species is used as a supplement. although it is now ...	1978	98355
passive immunization with an antibody to the beta-subunit of ovine luteinizing hormone as a method of early abortion--a feasibility study in monkeys (macaca radiata).	antiserum to the beta-subunit of ovine luteinizing hormone (olh-beta) raised in monkeys (macaca radiata) has been tested by a variety of criteria both in vivo and in vitro to establish its ability to neutralize olh, hlh, and human chorionic gonadotropin (hcg). passive administration of this antiserum caused inhibition of ovulation and termination of pregnancy in recipient monkeys as indicated by premature vaginal bleeding and a significant reduction in serum progesterone and estrogen levels. the ...	1978	98358
[method of remote orthogonal ecg and vcg recording in monkeys].		1978	98360
pre-immunization and post-exposure treatment with inactivated rabies vaccine of chick embryo cell culture origin (cec).	routine laboratory assay revealed that the potency of concentrated rabies vaccine of chick embryo cell culture (cec) origin was in the same level compared with suckling mouse brain (smb) vaccine. over one hundred persons received two doses of cec vaccine at an interval of one week and produced high level of neutralizing antibody against rabies virus. the monkeys experimentally infected with street rabies virus were satisfactorily protected by subcutaneous inoculation with cec vaccine one hour af ...	1978	98373
a pharmacologic profile of mcn-3495 [n-(1-methyl-2-pyrrolidinylidene)-n'-phenyl-1-pyrrolidinecarboximidamide], a new, orally effective hypoglycemic agent.	mcn-3495, a new compound unrelated strucuturally to the sulfonylureas or phenformin, has been found to produce a hypoglycemic effect in nondiabetic rats, dogs, mice, and monkeys. the minimum effective dose of mcn-3495 that lowers fasting blood glucose and improves glucose tolerance was found to be about 2.5 to 5 mg-per kilogram, per os, except in fasted monkeys, in which a tenfold greater potency was observed. when mcn-3495 was given repeatedly for three to five days, no tolerance to the hypogly ...	1978	98377
effects of dihydroegocristine on glucagon induced lipolysis and insulin release in man.		1978	98422
a device for chronic access to brain in conscious monkeys.		1978	98436
experimental fractures of monkey mandibles.	forty vervet monkey half mandibles, 20 with unerupted third molars and 20 with erupted third molars, were partially embedded in acrylic and loaded in an instron tensiometer. mandibles with unerupted third molars fractured at 15.8 +/- 2.5 kg while those having erupted third molars fractured at 26.4 +/- 4.2 kg. mandibles having unerupted third molars were shown to be significantly weaker than the mandibles with erupted third molar (t = 8.45, p less than 0.001).	1978	98455
biochemical effects on radioprotective agents on the liver microsomal hydroxylating system: in vitro studies.	the action of two radioprotectors--cysteamine and cystamine--on the liver microsomal multi-enzyme hydroxylating system, a key stem in drug and biological compounds metabolism, has been studied. their effects have been systematically analysed at the level of individual enzyme activities and global functions. the two compounds are quite inactive on nadph and nadh cytochrome c reductase activities, but slightly denature the cytochrome p450 into cytochrome p420. furthermore, they do inhibit to some ...	1978	98466
immunopathology of malaria.		1978	98476
pleiotropic effect of a rifampin-resistant mutation in bacillus subtilis.	rifampin-resistant (rifr) mutants were isolated spontaneously from bacillus subtilis strain 168. a fraction of the mutants did not grow on a minimal medium. a high concentration of one of the l-amino acids (glutamic acid, glutamine, arginine, proline, aspartic acid, or asparagine) was required to restore their growth on the medium. further analysis of one of the mutants (strain rf 161) suggested that the mutant is unable to use ammonia as a nitrogen source and requires amino acids instead. activ ...	1978	98517
formylation of initiator trna methionine in procaryotic protein synthesis: in vivo polarity in lactose operon expression.	eucaryotic and procaryotic organisms differ in two aspects of their translation machinery: polycistronic messengers are expressed as a sequence of individual proteins only in procaryotes, and the initiation of protein synthesis proceeds with an initiator trna which is found to be modified (formylated) in procaryotes and not in eucaryotes. in the present study, we show that formylation is required in vivo for the coordinate expression of the escherichia coli lactose operon. our experiments are co ...	1978	98518
evidence that the regulation of diphtheria toxin production is directed at the level of transcription.	it has been known for several decades that iron inhibits the production of diphtheria toxin by corynebacterium diphtheriae by preventing expression at maximal levels. we examined the inhibition kinetics of toxin production after the addition of either iron or rifampin to iron-limited cultures of c7 (betatox+). iron-mediated inhibition of toxin production was found to be linear within the range of 16 nm to 16 micron. the inhibition kinetics following the addition of iron or rifampin was almost id ...	1978	98519
altered mrna metabolism in ribonuclease iii-deficient strains of escherichia coli.	the metabolism of mrna from the lactose (lac) operon of escherichia coli has been studied in ribonuclease (rnase) iii-deficient strains (rnc-105). the induction lag for beta-galactosidase from the first gene was twice as long, and enzyme synthesis was reduced 10-fold in one such mutant compared with its isogenic rnc+ sister; in the original mutant strain ab301-105, synthesis of beta-galactosidase was not even detectable, although transduction analysis revealed the presence of a normal lac operon ...	1978	98520
isolation of immunoglobulin from splenic lymphocytes of inbred rats by triton x-100 solubilization.		1978	98589
quantitative determination of the serum antibody response to the capsular polysaccharide of bacteroides fragilis subspecies fragilis in women with pelvic inflammatory disease.	the antibody response to the capsular polysaccharide of bacteroides fragilis subspecies fragilis in women with acute pelvic inflammatory disease was quantitated using a sensitive radioactive antigen-binding assay. antibody detected by this technique correlated highly with antibody measured by quantitative precipitin analysis (r = 0.99). paired acute- and convalescent-phase sera obtained from women from whom b. fragilis subspecies fragilis was isolated by culdocentesis showed significantly greate ...	1978	98597
antibacterial functions of macrophages in experimental protein-calorie malnutrition. i. description of the model, morphologic observations, and macrophage surface igg receptors.	an experimental protein-calorie malnutrition was produced in weanling sprague-dawley rats. the model resembles human malnutrition with respect to weight loss, inanition, angular stomatitis, anemia, lymphopenia, hypoproteinemia with hypoalbuminemia, and marked thymic involution. in addition, systemic invasion by gram-negative rods was documented. however, no edema was produced, and animals did not survive for longer than six weeks on the protein-deficient diet. one percent glycogen was found to b ...	1978	98598
circadian variations in cortisol concentrations in the plasma of female rhesus monkeys.		1978	98605
physiological disposition and biotransformation of l-alpha-[2-3h]acetylmethadol (laam) in acutely and chronically treated monkeys.		1978	98628
experimental injury of the optic nerve with optic disc swelling.	an ultrastructural study utilizing horseradish peroxidase was performed to determine the mechanism and consequences of leakage of vascular protein following injury of the optic nerve. unilateral optic nerve injuries were produced in four rhesus monkeys by making a cautery lesion on the retrobulbar portion of the optic nerve. optic disc changes were followed with stereo fundus photography and fluorescein angiography. three to 14 days after injury horseradish peroxidase was given intravenously and ...	1978	98667
molecular cloning of the gene region coding for the chloroplast rrna of euglena gracilis.	e. gracilis chloroplast dna bam fragments e and d, coding for rrna were cloned separately using the plasmid pbr 322 as vector and e. coli as host. the newly constructed recombinant plasmids egcks 8 and egcks 11 (containing the bam hi fragments e and d respectively) were analysed and characterized by gel electrophoresis, electronmicroscopy and analytical ultracentrifugation.	1978	98702
the effect of thyrotropin-releasing hormone (trh) and somatostatin (ghrih) on growth hormone and prolactin secretion in vitro and in vivo in the domestic fowl (gallus domesticus).	the effects of thyrotropin-releasing hormone (trh) on growth hormone (gh) and prolactin (prl) secretion have been investigated in vitro and in vivo in domestic fowl. in both conscious and anaesthetized immature chickens the administration (i.v.) of trh (2.5 and 25 microgram/kg) significantly increased the concentration of plasma gh. the simultaneous administration of somatostatin (ghrih), 2.5 microgram/kg, to conscious birds significantly reduced the magnitude of the gh response to trh treatment ...	1978	98725
electron-microscopic identification of axonal initial segments belonging to interneurons in the dorsal lateral geniculate nucleus of the monkey.		1978	98733
changes in composition of tears of malnourished children.		1978	98738
reduced hepatic bilirubin uridine diphosphate glucuronyl transferase and uridine diphosphate glucose dehydrogenase activity in the human fetus.	hepatic bilirubin uridine diphosphate glucuronyl transferase (udpg-t) activity was 0.14 and 0.22 units in two fetuses aged 17 and 22 weeks, respectively, and less than 0.1 unit in 15 fetuses, aged 8--19 weeks compared to 0.68--1.99 units in 21 normal adults. hepatic uridine diphosphate glucose dehydrogenase (udpg-d) activity in 14 fetuses, aged 8--18 weeks, ranged from 6.2--15.0 units (mean = 11.3 +/- 0.7) compared to 28.8--49.2 units (mean = 39.6 +/- 2.5) in eight normal adults (p less than 0.0 ...	1978	98749
effect of dopamine on renal blood flow of baboon in endotoxin shock.	renal vasodilation observed in canine endotoxemia did not occur during endotoxin shock in the baboon: in fact, renal artery blood flow was markedly reduced. infusion of dopamine in the baboon restored the renal artery blood flow.	1978	98752
studies on the occurrence of peptococcus indolicus and corynebacterium pyogenes in abscesses in swine, and on the occurrence of pc. indolicus in apparently normal skin and mucous membranes of piglets.	pc. indolicus was isolated from 42.7% and cb. pyogenes from 48.7% of 150 pus-samples from abscesses in pigs (slaughter-house material, table i). in 41 specimens the two organisms were found together. further, pc. indolicus was demonstrated in 22.4% of 290 swabs from apparently normal skin and mucous membranes of piglets (autopsy material, table ii). by gel diffusion analysis the strains of pc. indolicus were referred to the serotypes b, c, d, e, or f. the type distribution (table iii) possibly r ...	1978	98755
the effect of 60-day hypokinesia on submaxillary, stomach, small intestine glands and on gastric secretion.		1978	106408
the metabolism and disposition of 3,4,4'-trichlorocarbanilide in the intact and bile duct-cannulated adult and in the newborn rhesus monkey (m. mulatta).		1978	106490
relationship between genetic variation in thermal stability and electrophoretic mobility of mouse beta-galactosidase.	we have examined the relationships between the genetic determinants for mouse beta-galactosidase heat stability and electrophoretic mobility, in order to clarify previous reports indicating that a variation for enzyme heat stability is restricted to kidney while that for electrophoretic mobility is expressed in all tissues. we find that the two phenotypes show concordant strain distributions and cosegregate in genetic crosses. in contrast to a previous report, the thermal stability variation is ...	1978	105715
an anthranilate synthase of the extreme aminase type in a species of blue-green bacteria (algae).	anthranilate synthase of agmenellum quadruplicatum, a unicellular species of blue-green bacteria, consists of two nonidentical subunits. a 72,000 dalton protein has aminase activity but is incapable of reaction with glutamine (amidotransferase) unless a second protein (18,000 molecular weight) is present. the small subunit was first detected through its ability to complement a partially purified aminase subunit from bacillus subtilis to produce a hybrid complex capable of amidotransferase functi ...	1978	105718
substrate specificity of 5'-methylthioadenosine phosphorylase from human prostate.	5'-methylthioadenosine phosphorylase was purified approx. 340-fold from human prostate by using affinity chromatography by hg-coupled sepharose. the enzyme, responsible for the breakdown of 5'-methylthioadenosine into adenine and methylthioribose 1-phosphate, was partially characterized. the apparent km for 5'-methylthioadenosine is 25 microm. it is activated by thiols and shows an absolute requirement for phosphate ions. new analogues of 5'-methylthioadenosine were prepared and their activity a ...	1978	105725
n-acetyl-beta-d-glucosaminidase in marmoset kidney, serum and urine.	n-acetyl-beta-d-glucosaminidase activities were determined in homogenates of marmoset kidney, in serum and in urine by using the 4-methylumbelliferyl substrate. the enzyme activity was separated into several components by deae-cellulose ion-exchange chromatography, starch-gel electrophoresis and isoelectric focusing. the kidney contained two major forms of the enzyme, a and b, which had similar ph optima and km values. the a-form bound to deae-cellulose at ph 6.8, migrated towards the anode on s ...	1978	105728
thermostable antigens from the bone marrow of several animal species.	studies on bone marrow extracts from ten animal species have revealed the presence of thermostable antigens. similar antigens were found in other organs as shown by immunodiffusion and cross-reactivity was demonstrated between the thermostable proteins from horse and dog and between cow and sheep proteins. using an immunoenzymatic reaction with glucose oxidase as the marker, the thermostable antigens were localized in the blood and bone marrow polymorphonuclear leukocytes and the myeloid cell li ...	1978	105786
preliminary experimental data on inhibition of beta-lactamase i from b. cereus by cu (++) and zn(++).		1978	106864
structural determination of 'cord factor' from a corynebacterium diphtheriae strain by a combination of mass spectral ionization methods: field desorption cesium cationization and electron impact mass spectrometry studies.	the composition and structure of a preparation of 'cord factor' (di-beta-hydroxy acyl trehaloses) from corynebacterium diphtheriae have been determined by a combination mass spectral ionization methods. the methods were tested by means of synthetic 6,6'-dicorynomycolate of alpha-d-trehalose prior to their use on natural products. the determination of the molecular weight of the components and the estimation of their relative abundance in the natural mixture were made by field desorption mass spe ...	1978	106902
[transplantation of cryopreserved bone marrow in the rat (author's transl)].		1978	107064
carbonic anhydrase of human endometrium: biochemical & clinical aspects.		1978	107115
effect of human serum thymic factor on immature t lymphocytes in acute leukemia and other hematologic malignancies.	in 37 patients with acute leukemia and in 13 patients with other hematologic malignancies, e-rosette formation of peripheral blood mononuclear cells, before and after incubation with human serum thymic factor, was studied. this assay showed that incubation with thymic factor caused a clear-cut increase of e-rosette-forming cells in 8 of the 37 acute leukemia patients. among the 13 patients with other hematologic malignancies, a similar effect was observed in two with pediatric hodgkin's disease ...	1978	107146
occult thyroid disease in an elderly hospitalized population.	measurements of thyroxine (t4), triiodothyronine (t3), thyrotropin (tsh), and t3 talc uptake (t3tu) were performed on 425 hospitalized patients over 60 years of age. unsuspected thyroid disease was found in 10 patients (2.4%); 9 were hypothyroid and 1 hyperthyroid. another 11% of the population had abnormal t4 or tsh levels but were not proved to have thyroid disease. repeat measurements in 10 of 40 patients with low serum t4 concentrations showed a return of the tests to normal. the low t4 leve ...	1978	107216