Publications

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the biology of the mouse mammary tumor virus. 19724349859
[is the breast carcinoma of the female caused by a virus?]. 19724114024
gel electrophoresis of reverse transcriptase activity of murine mammary tumour virions. 19724117769
particles containing rna-instructed dna polymerase and virus-related rna in human breast cancers.human breast cancers contain an rna related to that of mouse mammary tumor virus. in 79% of the breast malignancies examined, this type of rna is a 70s-component encapsulated with rna-instructed dna polymerase in a particle possessing the density characteristics of rna tumor viruses. further, the dna synthesized by the human rna enzyme complex hybridizes specifically with the rna of mouse mammary tumor virus. thus, four features diagnostic of agents similar to mouse mammary tumor virus are also ...19724117770
human leukaemic cells contain reverse transcriptase associated with a high molecular weight virus-related rna. 19724117891
homology between rna from human malignant breast tissue and dna synthesized by milk particles. 19724121809
oncogenicity of mammary tumor viruses. 19724122068
binding of concanavalin a to the envelope of two murine rna tumour viruses. 19724110930
regression of spontaneous mammary carcinomas using direct injections of neuraminidase and bcg. 19724111004
electron microscopy in mammary cancer research. 19724112452
electron microscopy of cell transformation by r-35 rat virus and comparative morphology with other oncogenic viruses. 19724112453
detection of tumour-associated transplantation antigen of bo-iv carcinoma on somatic cells of tumour-free syngeneic mice. ii. search for a common antigen in some organs and spontaneous mammary carcinomas. 19734122838
further evidence for oncornaviruses in human milk: the production of cores.cores, or nucleoids, have been isolated from particles in human milk. the cores have a density of 1.26-1.27 g/ml and contain a 60-70s rna in association with an rna-instructed dna polymerase. the data offer further evidence of similarity between human milk particles and animal rna tumor viruses. in addition, core isolation provides a new method for detection of these particles by minimizing the difficulties generated by the presence of cell-associated debris often found in the density region (1. ...19734124682
characterization and separation of viral dna polymerase in mouse milk.two dna polymerase with properties of viral rna-directed dna polymerase can be found in riii mouse milk. one enzyme is the polymerase of type-c viruses; this enzyme prefers manganese to magnesium with poly(ra).oligo(dt) as synthetic template, is inhibited by specific sera, and has an apparent molecular weight of 70,000. milk from balb/c and nih swiss mice contain a vast predominance of this type-c enzyme. the other dna polymerase from riii mouse milk prefers magnesium to manganese, is not inhibi ...19734124683
size, shape and surface structure of mouse mammary tumour virus (mtv). brief report. 19734125536
human mammary tumor virus. 19734125984
[reverse transcription and its significance in genetics and oncology]. 19734126002
in vitro production of mouse mammary tumor virus in a mouse mammary tumor ascites line.an ascites line derived from a spontaneous mouse mammary carcinoma produces, on explantation and cultivation in vitro, large amounts of oncornavirus particles. the biochemical, biophysical, and electron microscopic characteristics of the virions are described. molecular hybridization and immunological methods identify these virions as mouse mammary tumor virus.19734126729
mouse mammary tumour virus rna-dependent dna polymerase: requirements and products. 19734127734
[rna viruses as a cause of cancer]. 19734129093
studies on the acid mucopolysaccharide coat of viruses and transformed cells. 19734118912
effect of human milk on the mouse mammary tumor virus. 19734120354
remarks on virus-like particles in human breast cancer. 19734121275
reverse transcriptase-progress, problems and prospects. 19734130390
reverse transcriptases of rna tumor viruses: immunological relationships. 19734130394
an attempt to correlate rna-templated dna polymerase activity with virus-like particles in human milk: murine mammary tumor virus (mumtv) as a model system. 19734137532
the relevance of rna tumor viruses to human cancer. 19734137999
the relationship of visna, maedi and rna tumor viruses as studied by molecular hybridization. 19734139807
alteration of immunocompetence by mammary tumor virus. 19734350023
mammary tumor virus (mtv) infection of cba/bln mice involving production of antibodies to mtv. 19734350662
a radioimmunoassay for mtv-antigens. 19734352171
viropexis of type b particles in reticulum cell sarcoma of r3-dm strain mice. 19734352364
purification of virus glycoproteins by affinity chromatography using lens culinaris phytohaemagglutinin. 19734352507
possible viral aetiology of human breast cancer. 19734353391
improved hemagglutination inhibition assay for mammary tumor virus antigen.it is our experience that the use of sheep red blood cells pretreated with formaldehyde and pyruvaldehyde before sensitizing with viral antigen yields results that are comparable to that obtained by using the tannic acid method. the double aldehyde method provides the added advantage of being useful for assaying the viral antigen content in substances which contain high levels of interfering substances which would preclude the use of other assay methods.19734353693
murine mammary tumor cell clones with varying degrees of virus expression. 19734353952
etiology of breast cancer. ii. epidemiologic aspects.the epidemiology of breast cancer is reviewed with particular emphasis on its etiology. a number of studies suggest that differences in breast cancer incidence are associated with differences in marital status, number of pregnancies, age at menarche, age at menopause, height and weight, socioeconomic status, geographic location and residence. however, in no case is the evidence adequate to establish a "cause and effect" relationship. the genetic component of these associations may be of primary ...19734353980
[cross reaction between human breast cancer, mastopathy and murine mamma carcinoma: localization of the antigen in type-a-particle-virus]. 19734354922
[electronmicroscopic observations on mouse mammary tumor virus (mtv) with special regard to the extrusion of a-particles]. 19734355001
the effect of ph on the morphology, electrophoretic mobility, and infectivity of the mouse mammary tumor virus. 19734355022
[the effect of norsteroid treatment on the histologic structure of mastopathic breast tissue (author's transl)]. 19734355777
envelope of mouse mammary tumor virus studied by freeze-etching and freeze-fracture techniques.as part of a study of the cell surface changes associated with the production of murine mammary tumor virus, the structure of the envelope of this virus has been examined by using freeze-fracture techniques. both fracture and deep-etch surfaces were examined. the fracture faces contain 10-nm spheres comparable to those observed on fractured plasma membranes, although fewer in number. surfaces exposed by etching possess a highly regular hexagonal array of pits 25 nm apart. by examining freeze-fra ...19734355859
quantitation of mouse mammary tumor virus (mtv) virions by radioimmunoassay. 19734356324
[breast cancer and virus]. 19734356437
[editorial: viruses and breast cancers]. 19734356582
transcription of mouse mammary tumor virus genes in tissues from high and low tumor incidence mouse strains. 19734357097
quantitative studies of oncornaviruses in thin sections. 19734357378
comparison of three mammary tumor viruses in genetically similar susceptible mice. 19734357766
cultivation and characterization of balb-cfc3h mammary tumor cell lines. 19734358145
[viruses and mammary cancer. a survey (author's transl)]. 19734358520
fusion of xc rat sarcoma cells induced by murine leukaemia virus-infected mouse mammary tumour cells. absence of interference by simultaneously synthesized mammary tumour virus. 19734359242
some physical and biological characteristics of the mouse mammary tumor virus. 19734345152
[the effect of thymectomy, irradiation and immunization of c3h-he line mice on the development of syngenous mammary gland tumors]. 19734363186
[proof of the existence of antigens in virus induced mammary gland tumors of mouse line cba-bln]. 19734363190
[location of viral antigens in mouse mammary adenocarcinoma by immunoperoxidase]. 19734362169
[immunofluorescence and the immunoelectron microscopy of virus-induced tumors of the mammry glands of cba-bln strain mice]. 19734362195
immunotherapeutic studies in mice with the methanol-extraction residue (mer) fraction of bcg: solid tumors. 19734362523
life cycle of the murine mammary tumor virus, and a comparison with similar forms reported in human mammary carcinomas. 19734362650
antigenic structure of murine mammary tumour viruses. 19734363444
[ideas concerning cancer]. 19734347602
intracytoplasmic a particles: mouse mammary tumor virus nucleoprotein cores?a rapid method for the isolation of intracytoplasmic a particles, the putative intracellular nucleoprotein cores of mouse mammary tumor virus (mtv), is presented. spontaneous c3h/he mouse mammary tumors and transplantable mouse leydig cell tumor were used as source material. large aggregations of intracytoplasmic a particles were separated from cellular contaminants on discontinuous sucrose gradients and subsequently further purified by isopycnic banding in linear sucrose gradients. the purified ...19734349496
dna polymerase activity and dna synthesis in preneoplastic nodule outgrowths of balb-c and c3h mouse mammary gland. 19734349763
structural characteristics of some murine rna tumor viruses studied by lactoperoxidase iodination.iodination by the noninvasive enzymatic lactoperoxidase technique has been used to study the enzyme-accessible and enzyme-inaccessible proteins of three oncorna viruses (radiation leukemia virus, moloney leukemia virus, and mouse mammary tumor virus). the number and relative molecular weight of proteins associated with virion preparations purified on sucrose gradients were characterized by scans of coomassie blue-stained bands after dodecyl sulfate-polyacrylamide gel electrophoresis. gel scans f ...19734346036
rna related to that of a murine leukemia virus in burkitt's tumors and nasopharyngeal carcinomas.rna homologous to that of the rauscher leukemia virus has been detected in burkitt's lymphomas and nasopharyngeal carcinomas. earlier excellent experimental evidence has linked these two human tumors with the epstein-barr virus, a dna-containing agent.19734346039
studies on the interrelationship of type b and type c virus particles in breast cancer and in leukemia. 19734360177
[regulation of immunologic tumor-host relations in virus-induced mammary carcinoma of the mouse]. 19734361625
possible viral etiology of human cancer. 19734367762
mammary tumor virus (mtv) antigens in normal and mammary tumor-bearing mice. 19734364792
[regulating mechanisms in the tumor-host relation in murine mannary carcinomas]. 19734375940
[correlation between the production of mature mammary tumour virus particles and the histomorphological differentiation of murine mammary tumours].the mammary tumour virus (mtv) contents of mammary tumours (mt's) of various mouse strains were investigated by means of the indirect immunofluorescence technique and the electron microscopy. only in acinus-forming, well differentiated mt's mtv-b particles could be observed in high quantity. the release of b particles seems to be correlated with the degree of structural ripeness of the tumor tissue. as to intracytoplasmic a particles such a strong relationship could not be found out. many a part ...19744376679
proceedings: preparation and partial chemical analysis of milk-fat-globule membrane and mammary tumour virus obtained from swiss albino mice. 19744376764
characterization of x gf mice with respect to their resistance to oncogensis. 19744377184
[the most recent biochemical studies in experimental animal models of breast neoplasms]. 19744377391
a locus affecting circulating interferon levels induced by mouse mammary tumour virus. 19744364881
immunochemical characterization of two major polypeptides from murine mammary tumor virus.a major murine mammary tumor viral (mmtv) antigen, sl, originally described by nowinski et al. (1967, 1968, 1971), has been purified from riii mouse milk mmtv by sequential ion-exchange and gel chromatography. the purified protein with sl antigenic reactivity contains carbohydrate, and has an apparent minimal molecular weight of 52,000. it can be designated as gp52 (sl). another major mmtv viral protein with a molecular weight of 27,000 has also been isolated, and antisera have been prepared aga ...19744364896
titrations of various mouse mammary tumor viruses in different mouse strains. 19744365388
mechanism of resistance to mammary tumor development in c57bl and i strains of mice. ii. inherent differences between the two strains. 19744365389
relationship between hydration and proton nuclear magnetic resonance relaxation times in tissues of tumor-bearing and non-tumor-bearing mice: implications for cancer detection. 19744365678
homology between human breast tumour rna and mouse mammary tumour virus genome. 19744365713
presence and transmission of mammary tumor virus and leukemia virus in the balb-cfriii mouse. 19744365907
lymphocyte inhibition by mammary tumor virus in patients with breast cancer. 19744366357
radioimmunoassay for mouse mammary tumor virus-associated antigen. 19744367180
expression of mammary tumor virus antigen on the membranes of lymphoid cells. 19744367759
[epithelial culture isolated from t 3 mouse mammary adenocarcinoma: characteristics during 5 years]. 19744368127
an epidemiologic study of breast cancer. 19744369771
editorial: neuroblastoma: possible viral aetiology? 19744369946
of birds and mice and men: comments on the use of animal models and molecular hybridization in the search for human tumor viruses. 19744371153
human cancer and animal viral oncology. 19744371267
immunologic evidence for horizontal transmission of mtv. 19744371310
cation preferences for poly(rc)-oligo(dg)-directed dna synthesis by rna tumor viruses and human milk particulates. 19744371968
immunological relationship between antigens induced by leukemia virus & mammary tumor virus in an inbred mouse strain. 19744372168
distribution of virus particles and mammary tumor virus antigens in mouse mammary tumors, transformed balb-c mouse kidney cells, and gr ascites leukemia cells. 19744372372
histocompatibility genes (the h-2 complex) and susceptibility to mammary tumor virus in mice. 19744372373
carcinogenic effects of oral diethylstilbestrol on c3h male mice with and without the mammary tumor virus. 19744372382
further observations on the production of oncornaviruses by mjy-alpha cell line. 19744372383
structure of the mouse mammary tumor virus: characterization of bald particles.the polypeptide, antigenic, and morphological structure of the mouse mammary tumor virus was studied following protease digestion of intact virions. intact, untreated virions (rho = 1.17 g/ml) had characteristic envelope spikes, five major polypeptides, and were precipitated by antisera against gp52. two of the major polypeptides, with molecular weights of 52,000 (gp52) and 36,000 (gp36), had carbohydrate moieties. protease treatment resulted in spikeless, "bald" particles (rho = 1.14 g/ml), whi ...19744372399
[further investigation to the immunology of murine mammary tumours of the cba-bln strain using the colony inhibition tests (author's transl)]. 19744372968
the role of latent viruses in subline differentiation in inbred strains of mice. 19744373307
detection of mouse mammary tumor virus in cat kidney cells infected with purified b particles from riii milk. 19744373580
tumor-specific antigens and reexpression of fetal antigens in mammalian cells. 19744373784
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