Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [short- and long-term effects of the outpatient medical rehabilitation for patients with asbestosis]. | the aim of this study was to evaluate the effects of an outpatient medical rehabilitation (omr) mainly composed of exercise therapy and sports for patients with asbestosis. following the model of hamburg the omr focuses on keeping up lasting effects. | 2010 | 19918720 |
| stimulatory effects of thyroid hormone on brain angiogenesis in vivo and in vitro. | thyroid hormone is critical for the proper development of the central nervous system. however, the specific role of thyroid hormone on brain angiogenesis remains poorly understood. treatment of rats from birth to postnatal day 21 (p21) with propylthiouracil (ptu), a reversible blocker of triiodothyronine (t3) synthesis, resulted in decreased brain angiogenesis, as indicated by reduced complexity and density of microvessels. however, when ptu was withdrawn at p22, these parameters were fully reco ... | 2010 | 19861975 |
| chemoradiation for patients with advanced oral cavity cancer. | patients with advanced oral cavity cancer (occ) typically have not been enrolled in clinical trials utilizing contemporary multimodality strategies. there exist dogmatic expectations of inferior outcome in occ patients secondary to ineffectiveness of treatment and unacceptable toxicity. the purpose of this study was to analyze survival, swallowing function, and incidence of osteoradionecrosis (orn) of patients with stage iii/iv occ who have undergone primary concomitant chemoradiotherapy (crt). | 2010 | 19856305 |
| outcomes of minimally invasive endoscopic resection of anterior skull base neoplasms. | the objective of this study was to review clinical outcomes of minimally invasive endoscopic resection (mier) for anterior skull base (asb) neoplasms. | 2010 | 19877265 |
| patterns of radiotherapy practice for pancreatic cancer in japan: results of the japanese radiation oncology study group (jrosg) survey. | to determine the patterns of radiotherapy practice for pancreatic cancer in japan. | 2010 | 19879060 |
| profiling the selectivity of dna ligases in an array format with mass spectrometry. | this article describes a method for the global profiling of the substrate specificities of dna ligases and illustrates examples using the taq and t4 dna ligases. the method combines oligonucleotide arrays, which offer the benefits of high throughput and multiplexed assays, with mass spectrometry to permit label-free assays of ligase activity. arrays were prepared by immobilizing ternary biotin-tagged dna substrates to a self-assembled monolayer presenting a layer of streptavidin protein. the arr ... | 2010 | 19854942 |
| immediate microsurgical reconstruction after tumor ablation predicts survival among patients with head and neck carcinoma. | the purpose of this study was to examine whether or not immediate microvascular free flap reconstruction influences survival among treated patients suffering from oral squamous cell carcinoma (oscc), controlling for demographic, clinical, and tumor characteristics. | 2010 | 19841982 |
| empty sella and primary autoimmune hypothyroidism. | in order to assess the association between empty sella (es) and primary autoimmune hypothyroidism, and the possibility of a common pathogenesis. we retrospectively studied all patients with presumed es diagnosed in the last 20 years, most of whom were treated by our endocrinology department. subjects with a known etiology were excluded. incomplete records or those with a doubtful diagnosis were also excluded. a total of 56 subjects were included in the study. es was diagnosed by pituitary mri. t ... | 2010 | 19823763 |
| impact of comorbidity on short-term mortality and overall survival of head and neck cancer patients. | in 2001, we presented a cox regression model that is able to predict survival of the newly diagnosed patient with head and neck squamous cell carcinoma (hnscc). this model is based on the tnm classification and other important clinical variables such as age at diagnosis, sex, primary tumor site, and prior malignancies. we aim to improve this model by including comorbidity as an extra prognostic variable. accurate prediction of the prognosis of the newly diagnosed patient with head and neck cance ... | 2010 | 19827120 |
| structure of the small outer capsid protein, soc: a clamp for stabilizing capsids of t4-like phages. | many viruses need to stabilize their capsid structure against dna pressure and for survival in hostile environments. the 9-kda outer capsid protein (soc) of bacteriophage t4, which stabilizes the virus, attaches to the capsid during the final stage of maturation. there are 870 soc molecules that act as a "glue" between neighboring hexameric capsomers, forming a "cage" that stabilizes the t4 capsid against extremes of ph and temperature. here we report a 1.9 a resolution crystal structure of soc ... | 2010 | 19835886 |
| laser evoked potentials in amyotrophic lateral sclerosis. | the pathophysiological mechanism of the pain in als is still unclear. the aim of the study was to evaluate the laser evoked potentials (leps) in als patients in relation to their clinical features. twenty-four als patients were selected. pain features were assessed and their intensity was measured by a 0-10 vas. leps were recorded in all patients and in 23 healthy subjects. the dorsum of both hands was stimulated, at laser stimuli intensity of 7.5 w, with 10s inter-stimulus interval and 25 ms du ... | 2010 | 19836030 |
| impact of android overweight or obesity and insulin resistance on basal and postprandial sr-bi and abca1-mediated serum cholesterol efflux capacities. | since android overweight/obesity and insulin resistance are independent risk factors for cardiovascular disease, we investigated their impact on basal and postprandial scavenger receptor bi (sr-bi) and atp binding cassette transporter a1 (abca1)-mediated serum cholesterol efflux. twelve android overweight to obese and 9 normal weight controls women underwent body composition analysis by dual energy x-ray absorptiometry, a euglycemic hyperinsulinemic clamp, and an oral fat load with blood samplin ... | 2010 | 19837407 |
| a randomized clinical trial of thermoplastic retainer wear. | the purpose of this study was to determine whether thermoplastic retainers need to be worn full-time for a limited period or whether part-time wear from the outset is adequate to maintain tooth position, arch form, and occlusion. this study was a randomized clinical trail, conducted in a district general hospital. sixty-two participants were enrolled in the study. group 1, full-time wear, consisted of 30 patients (12 males and 18 females, aged 13.6 +/- 1.5 years) and group 2, part-time wear, 32 ... | 2010 | 19828592 |
| maternal thyroid function during gestation is related to breech presentation at term. | to study the relationship between suboptimal maternal thyroid function during gestation and breech presentation at term. | 2010 | 19832853 |
| modeling eeg fractal dimension changes in wake and drowsy states in humans--a preliminary study. | aim of this preliminary study was to examine and compare topographic distribution of higuchi's fractal dimension (fd, measure of signal complexity) of eeg signals between states of relaxed wakefulness and drowsiness, as well as their fd differences. the experiments were performed on 10 healthy individuals using a fourteen-channel montage. an explanation is offered on the causes of the detected fd changes. fd values of 60s records belonging to wake (hori's stage 1) and drowsy (hori's stages 2-4) ... | 2010 | 19822155 |
| tumor volume, tumor percentage involvement, or prostate volume: which is predictive of prostate-specific antigen recurrence? | to compare the effects of tumor volume (tv), tumor percentage involvement (tpi), and prostate volume (pv) on prostate-specific antigen (psa) recurrence (psar) after radical prostatectomy (rp). | 2010 | 19819532 |
| prospective randomized controlled trial of robotic versus open radical cystectomy for bladder cancer: perioperative and pathologic results. | in recent years, surgeons have begun to report case series of minimally invasive approaches to radical cystectomy, including robotic-assisted techniques demonstrating the surgical feasibility of this procedure with the potential of lower blood loss and more rapid return of bowel function and hospital discharge. despite these experiences and observations, at this point high levels of clinical evidence with regard to the benefits of robotic cystectomy are absent, and the current experiences repres ... | 2010 | 19853987 |
| supplementation of cottonseed, linseed, and noug seed cakes on feed intake, digestibility, body weight, and carcass parameters of sidama goats. | a digestibility, feed intake, and carcass evaluation experiment using 20 yearling intact male sidama goats weighing 16.4 +/- 0.63 kg (mean +/- sd) was conducted in ethiopia with the objectives to determine feed intake, digestibility, body weight (bw) gain, and carcass parameters. the treatments included feeding natural pasture hay (t1, control) and supplementation with cottonseed cake (284 g-t2), linseed cake (250 g-t3), and noug seed cake (296 g-t4) on dry matter (dm) basis to supply 85 g crude ... | 2010 | 19809885 |
| fixed orthodontic appliance therapy and its impact on oral health-related quality of life in chinese patients. | to determine changes in oral health-related quality of life (ohrqol) during fixed orthodontic appliance therapy in chinese patients. | 2010 | 19852639 |
| sex steroid levels, oocyte maturation and spawning performance in waigieu seaperch (psammoperca waigiensis) exposed to thyroxin, human chorionic gonadotropin, luteinizing hormone releasing hormone and carp pituitary extract. | in the present study, we have investigated the sex steroid hormone levels, oocyte maturation and spawning performance in waigieu seaperch (psammoperca waigiensis) exposed to different doses (0, (control), 0.05, 0.25 and 0.5 mg/kg fish) of thyroxin (t(4)) both through diet (continuously) and injection (single injection). in addition, we also studied plasma steroid hormone levels and spawning performances in female fish injected with a single dose of d-ala(6), pro(9)-net-mgnrh (lhrha: 50 microg/kg ... | 2010 | 19896549 |
| olfactory ensheathing cells reduce duration of autonomic dysreflexia in rats with high spinal cord injury. | autonomic dysreflexia is a common complication in high spinal cord injury and can result in serious consequences and death. here we have examined the effect of acute transplantation of olfactory ensheathing cells on cardiovascular functions in rats. after t4 transection, radio-telemetric recording in conscious animals was used to study blood pressure and heart rate at rest and during autonomic dysreflexia for up to 8 weeks post-injury. olfactory ensheathing cells from syngeneic rats were transpl ... | 2010 | 19896908 |
| effect of supplementation of simada sheep with graded levels of concentrate meal on feed intake, digestibility and body-weight parameters. | the experiment consisting of 7 days of digestibility and 90 days of feeding trial was conducted at wogda (ethiopia) to determine the effect of supplementation of graded levels of concentrate mix (cm) on feed intake, digestibility, and body weight (bw) change in hay-based feeding of simada sheep. twenty-yearling simada sheep with a mean initial bw of 17.9 +/- 0.81 kg (mean +/- sd) were used in randomized complete block design arranged into five blocks of four animals. the four dietary treatments ... | 2010 | 19898949 |
| gemcitabine as single agent in pretreated t-cell lymphoma patients: evaluation of the long-term outcome. | peripheral t-cell lymphoma unspecified (ptclu) and mycosis fungoides (mf) often show resistance to conventional chemotherapy. gemcitabine should be considered a suitable option. we report the long-term update of 39 pretreated t-cell lymphoma patients treated with gemcitabine. | 2010 | 19887465 |
| results of european pooled analysis of iort-containing multimodality treatment for locally advanced rectal cancer: adjuvant chemotherapy prevents local recurrence rather than distant metastases. | the purpose of this study is to analyze the pooled results of multimodality treatment of locally advanced rectal cancer (larc) in four major treatment centers with particular expertise in intraoperative radiotherapy (iort). | 2010 | 19889621 |
| abnormalities of thyroid function in japanese patients with metastatic renal cell carcinoma treated with sorafenib: a prospective evaluation. | the objective of this study was to characterize features of thyroid dysfunction in japanese patients with metastatic renal cell carcinoma (rcc) who were treated with sorafenib. we performed a prospective observational study including 69 japanese patients who were diagnosed as having metastatic rcc refractory to cytokine therapy and subsequently treated with sorafenib for at least 12 weeks. thyroid function was assessed before and every 4 weeks after the initiation of sorafenib treatment. of the ... | 2010 | 19914105 |
| clinicopathological features and prognostic factors of proximal gastric carcinoma in a population with high helicobacter pylori prevalence: a single-center, large-volume study in korea. | the incidence of gastric cancers has fallen in recent decades. however, a substantial reduction in helicobacter pylori prevalence and a substantial increase in the incidence of proximal gastric cancer (pgc) have been observed in the west and japan, but not in other east asian countries. the purpose of this large-volume study was to analyze prevalence, clinicopathological features, and prognosis of pgc compared with other types of gastric cancer in korea, where there is high incidence of h. pylor ... | 2010 | 19882188 |
| feed intake, digestibility, nitrogen utilization, and body weight change of sheep consuming wheat straw supplemented with local agricultural and agro-industrial by-products. | effects of supplementing sheep consuming wheat straw with local agro-industrial by-products on feed intake, growth, digestibility and nitrogen utilization were determined. thirty 1-year-old local wethers, with a mean (+/-sd) live weight of 19.8 (+/-1.06) kg, were assigned to five treatments: wheat straw + atella (t1), wheat straw + atella + poultry litter (t2), wheat straw + atella + coffee pulp (t3), wheat straw + atella + coffee pulp + poultry litter (t4), hay + concentrate (t5). a 7-day diges ... | 2010 | 19882225 |
| urine iodine levels in preeclamptic and normal pregnant women. | the aim of this study was to investigate the urine iodine concentration in women with severe preeclampsia and in healthy women in erzurum, turkey. urine specimens were obtained from 40 severe preeclampsia and 18 healthy pregnant women. urinary iodine levels were determined by the foss method based on the sandell-kolthoff reaction. the urinary iodine level for women with severe preeclampsia was 4.25 +/- 2.7 microg/dl, lower than 20.89 +/- 6.4 microg/dl of urinary iodine for healthy pregnant women ... | 2010 | 19865803 |
| evaluation of two group therapies to reduce fear of progression in cancer patients. | this paper aims to evaluate the effects of two psychotherapeutic interventions on dysfunctional fear of progression (fop) in cancer patients and to investigate illness-specific influences. | 2010 | 19865833 |
| effects of different levels of dried sweet potato (ipomoea batatas) leaves inclusion in finisher ration on feed intake, growth, and carcass yield performance of ross broiler chicks. | the effect of supplementation with increasing levels of dried leaves of sweet potato (ipomoea batatas) on feed intake, body weight gain, and carcass yield characteristics of finisher ross broiler chicks was studied at haramaya university, ethiopia. three hundred ross broiler chicks aging 29 days and weighing 540 +/- 5.28 g (mean +/- sd) were randomly distributed to 15 pens, each with 20 chicks, representing five treatment rations each with three replications. dietary treatments consisted of incl ... | 2010 | 19866368 |
| the prognostic significance of bladder neck invasion in prostate cancer: is microscopic involvement truly a t4 disease? | since the widespread of prostate-specific antigen-based screening, prostate cancer at clinical stage t4 has become rare. most bladder invasion is actually detected on radical prostatectomy specimens as a microscopic bladder neck involvement (bni). the 2002 tumour-node-metastasis (tnm) classification system classified prostate cancer with bni within a unified pt4 category and rendered it equivalent to invasion into the pelvic wall musculature or external sphincter; this decision is controversial. ... | 2010 | 19863529 |
| the baseplate wedges of bacteriophage t4 spontaneously assemble into hubless baseplate-like structure in vitro. | the baseplate of phage t4 is an important model system in viral supramolecular assembly. the baseplate consists of six wedges surrounding the central hub. we report the first successful attempt at complete wedge assembly using an in vitro approach based on recombinant proteins. the cells expressing the individual wedge proteins were mixed in a combinatorial manner and then lysed. using this approach, we could both reliably isolate the complete wedge along with a series of intermediate complexes ... | 2010 | 19896486 |
| genetic insertions and diversification of the polb-type dna polymerase (gp43) of t4-related phages. | in escherichia coli phage t4 and many of its phylogenetic relatives, gene 43 consists of a single cistron that encodes a polb family (polb-type) dna polymerase. we describe the divergence of this phage gene and its protein product (gp43) (gene product 43) among 26 phylogenetic relatives of t4 and discuss our observations in the context of diversity among the widely distributed polb enzymes in nature. in two t4 relatives that grow in aeromonas salmonicida phages 44rr and 25, gene 43 is fragmented ... | 2010 | 19896487 |
| controversy surrounding the role for routine central lymph node dissection for differentiated thyroid cancer. | differentiated thyroid cancer (dtc), with a rapidly increasing incidence is the most common endocrine malignancy, but with generally favorable survival. total thyroidectomy with 'therapeutic' cervical lymph node dissection for involved lymph nodes is the standard of care. a more controversial topic is whether routine 'prophylactic' central lymph node dissection (clnd) in patients without evidence of lymph node metastasis should be performed in patients with dtc, as suggested by several recent ma ... | 2010 | 19864950 |
| long-term effects of rapid maxillary expansion followed by fixed appliances. | to evaluate the long-term changes in maxillary arch widths, overjet, and overbite in patients who were treated with rapid maxillary expansion (rme) followed by edgewise appliances. | 2010 | 19852633 |
| p53 mutation status predicts pathological response to chemoradiotherapy in locally advanced esophageal cancer. | the p53 gene promotes cell-cycle arrest and apoptosis upon dna damage and is associated with chemo- and radiosensitivity of cancer cells. however, its clinical significance has not been confirmed, especially in squamous cell carcinoma of the esophagus (escc). we investigated the correlation between p53 disorders (gene mutation and protein accumulation) and the effects of chemoradiotherapy (crt). | 2010 | 19885698 |
| long-term follow-up and a detailed prognostic analysis of patients with oropharyngeal cancer treated with radiotherapy. | to find a prognostic factor for patients with oropharyngeal cancer (opc) who were followed for long term after definitive radiotherapy. | 2010 | 19859735 |
| thymidine phosphorylase to dihydropyrimidine dehydrogenase ratio as a predictive factor of response to preoperative chemoradiation with capecitabine in patients with advanced rectal cancer. | to identify if thymidine phosphorylase (tp), dihydropyrimidine dehydrogenase (dpd), and ratio tp/dpd levels in tumor tissues are potential predictive factors for response to combined preoperative chemoradiation with capecitabine, in patients with locally advanced rectal cancer (larc). | 2010 | 19877119 |
| establishment of yeast reporter assay systems to detect ligands of thyroid hormone receptors alpha and beta. | thyroid hormones are essential for proper development and differentiation in vertebrates. recently, concern over the disruption of thyroid hormone homeostasis by industrial chemicals and environmental pollutants has been spreading. to evaluate these chemicals, several bioassays have been developed to detect thyroid hormone ligand activity. nevertheless, a simple and useful assay is required for the assessment of an enormous number of environmental chemicals. we established yeast reporter assays ... | 2010 | 19853653 |
| neoadjuvant chemoradiotherapy with capecitabine followed by laparoscopic resection in locally advanced tumors of middle and low rectum - toxicity and complications of the treatment. | the aim of this prospective study is to elucidate feasibility of protocol of neoadjuvant concomitant radiochemotherapy with capecitabine and long course radiotherapy with subsequent laparoscopic rectal resection. we assessed treatment toxicity, downstaging rate, pathological response to the neoadjuvant treatment, surgery complications, rate of conversions and sphincter-preserving surgical procedures, and intraoperative and early postoperative complications too. | 2010 | 19879716 |
| clinical outcome in 520 consecutive danish rectal cancer patients treated with short course preoperative radiotherapy. | the purpose of this study was to analyse the results of preoperative short course radiotherapy in a consecutive, national cohort of patients with rectal cancer. | 2010 | 19880268 |
| compensatory mechanisms to maintain blood pressure in paraplegic rats: implication of central tachykinin nk-1 and nk-3 receptors? | people with high level spinal cord injury (sci) suffer from both hypotension and spontaneous hypertension due to loss of supraspinal control of spinal sympathetic outflow. few reports have addressed whether any changes occur in central regulation of blood pressure (bp) and heart rat (hr) at the supraspinal level. central tachykinin nk-1 and nk-3 receptors are located in many cardiovascular areas in the brain and are known to modulate bp and hr. this study examined the intracerebroventricular (i. ... | 2010 | 20096457 |
| histopathologic basis for the favorable survival after resection of intraductal papillary mucinous neoplasm-associated invasive adenocarcinoma of the pancreas. | to identify pathologic features that may account for the favorable survival after resection of invasive pancreatic adenocarcinoma arising in the setting of intraductal papillary mucinous neoplasm (ipmn) compared with standard pancreatic ductal adenocarcinoma (pda) in the absence of ipmn. | 2010 | 20142731 |
| hypopituitarism is uncommon after aneurysmal subarachnoid haemorrhage. | aneurysmal subarachnoid haemorrhage (sah) has recently been reported as a common cause of chronic hypopituitarism, and introduction of routine neuroendocrine screening has been advocated. we aimed at estimating the risk of hypopituitarism after sah using strict criteria including confirmatory testing in case of suggested insufficiency. | 2010 | 20105184 |
| reaction mechanisms of the multicopper oxidase cueo from escherichia coli support its functional role as a cuprous oxidase. | cueo from escherichia coli is a multicopper oxidase (mco) involved in copper tolerance under aerobic conditions. it features four copper atoms that act as electron transfer (t1) and dioxygen reduction (t2, t3; trinuclear) sites. in addition, it displays a methionine-rich insert which includes a helix that blocks physical access to the t1 site and which provides an extra labile site t4 adjacent to the t1 center. this t4 site is required for cueo function. like many mcos, cueo exhibits phenol oxid ... | 2010 | 20088522 |
| lessons from the lysozyme of phage t4. | an overview is presented of some of the major insights that have come from studies of the structure, stability, and folding of t4 phage lysozyme. a major purpose of this review is to provide the reader with a complete tabulation of all of the variants that have been characterized, including melting temperatures, crystallographic data, protein data bank access codes, and references to the original literature. the greatest increase in melting temperature (t(m)) for any point mutant is 5.1 degrees ... | 2010 | 20095051 |
| the use of sugammadex in a patient with myasthenia gravis. | myasthenia gravis, affecting neuromuscular transmission, leads to a large variability in sensitivity to depolarising and non-depolarising neuromuscular blocking drugs. we report the successful use of the modified mu-cyclodextrin sugammadex in a myasthenic patient to reverse a rocuronium-induced deep level of neuromuscular block. after spontaneous neuromuscular recovery of t2 (second twitch of the train-of-four series), we administered 2 mg.kg(-1) of sugammadex intravenously, reversing neuromuscu ... | 2010 | 20105151 |
| effects of certain antioxidants on lipid peroxidation process in lung homogenates of l thyroxine-receiving rats. | a possible role of antioxidants in thyreotoxicosis was investigated. we examined the parameters of lipid peroxidation (lpo): conjugated dienes (cd), malondialdehyde (mda), schiff bases (sb) in lung homogenates of male wistar rats. | 2010 | 20150865 |
| metabolic effects of 20-oh-ecdysone in ovariectomized rats. | postmenopausal women develop often obesity which may be prevented by 20-oh-ecdysone (ecd). this was investigated in ovariectomized (ovx) rats. they were orally treated with 3 doses of ecd (18, 56 or 116 mg/day/animal). positive controls received 159 microg estradiol (e2). quantitative computer tomography at the level of the abdomen and the metaphysis of the tibia allowed estimation of surface, fat depots and muscles. the highest dose of ecd resulted in serum concentrations of 0.4 x 10(-6)m. seru ... | 2010 | 20097286 |
| genetic variability of vascular endothelial growth factor and prognosis of head and neck cancer in a brazilian population. | vascular endothelial growth factor (vegf) is one of the most potent endothelial cell mitogens and plays a critical role in angiogenesis. polymorphisms in this gene have been evaluated in patients with several types of cancer. the objectives of this study were to determine if there was an association of the -1154g/a polymorphism of the vegf gene with head and neck cancer and the interaction of this polymorphism with lifestyle and demographic factors. additionally, the distribution of the vegf gen ... | 2010 | 20098841 |
| risk factors for radiation maculopathy after ophthalmic plaque radiation for choroidal melanoma. | to determine how tumor characteristics and radiation dose affect the incidence of radiation maculopathy (rm). | 2010 | 20138602 |
| reduced stratifin expression can serve as an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma. | stratifin plays an important role in cancer biology by interfering with intracellular signalling pathways and cell-cycle checkpoints. decreased expression of stratifin gene has been reported to be a poor prognostic indicator in a variety of human malignant tumors. | 2010 | 20108042 |
| oxidative stress: a required condition for thyroid cell proliferation. | goiter is associated with increased oxidative stress (os). we studied the effects of an anti-inflammatory agent, 15 deoxy-delta12,14-prostaglandin j2 (15dpgj2) and an antioxidant, n-acetylcysteine (nac), on os, thyroid function, and goiter expansion in a model of goiter induced by propylthiouracil (ptu) or perchlorate. os was assessed by the immunodetection of 4-hydroxynonenal, thyroid function by measuring thyroxin (t4) and thyrotropin (tsh) plasma levels and detecting t4-rich thyroglobulin (tg ... | 2010 | 20093493 |
| comparison of the molecular influences of no-induced lesions in dna strands on the reactivity of polynucleotide kinases, dna ligases and dna polymerases. | nitric oxide (no) causes dna damage, generating xanthine (xan, x) and oxanine (oxa, o) from guanine (gua, g) and hypoxanthine (hyp, h) from adenine (ade, a) by nitrosative oxidation. although these no-induced lesions have been thought to cause mutagenic problems in cellular systems, the influence of these lesions on enzymatic functions has not yet been compared systematically. in this study, we investigated the effect of no-induced lesions on the activities of dna-binding/recognizing enzymes suc ... | 2010 | 20097903 |
| [free anterolateral thigh myocutaneous flap for reconstruction of soft tissue defects following en block resection of tongue cancer]. | to evaluate the results of the reconstruction of the soft tissue defects following the en block resection of tongue cancer using free anterolateral thigh myocutaneous flaps. | 2010 | 20135979 |
| complete frozen section margins (with measurable 1 or 5 mm thick free margin) for cancer of the tongue: part 2: clinical experience. | to obtain completely negative margins of 1 to 5 mm at the time of surgery for oral tongue squamous cell carcinoma by using a mohs-like technique. | 2010 | 20122340 |
| thyroid autoimmunity and treatment response to escitalopram in major depression. | there is evidence that immune alterations play an important part in the pathogenesis of major depression. thyroid autoimmunity has been found in association with major depression in several studies. | 2010 | 20088751 |
| high-frequency phage-mediated gene transfer in freshwater environments determined at single-cell level. | lateral gene transfer by phages has contributed significantly to the genetic diversity of bacteria. to accurately determine the frequency and range of phage-mediated gene transfer, it is important to understand the movement of dna among microbes. using an in situ dna amplification technique (cycling primed in situ amplification-fluorescent in situ hybridization; cprins-fish), we examined the propensity for phage-mediated gene transfer in freshwater environments at the single-cell level. phage p1 ... | 2010 | 20090786 |
| thyroid profile of term appropriate for gestational age neonates in nigeria: a forerunner to screening for congenital hypothyroidism. | thyroid hormones in normal quantity are vital for physical growth and mental development during fetal and postnatal life. the available publications in sub-saharan africa on the thyroid function of newborn infants was reported in babies delivered in moderate to severe goitre zones; utilizing the hormone levels from these studies may have a measure of bias. newborn screening for congenital hypothyroidism (ch) in sub-saharan africa is still a mirage, the technicality of the best timing for collect ... | 2010 | 20085966 |
| potential to use ultraviolet-treated bacteriophages to control foodborne pathogens. | the use of replication-deficient uv-treated bacteriophages, or phages, presents an alternative to viable phages for food biocontrol applications. nontransducing uv-treated phages, if used correctly, are unlikely to produce viable progeny phages, which might otherwise mediate undesirable horizontal gene transfer events. phage t4 and escherichia coli were used as a model system to examine this possibility. uv-treated phages were able to cause a reduction in the optical density of outer membrane-fr ... | 2010 | 20113208 |
| predictors of occult nodal metastasis in colon cancer: results from a prospective multicenter trial. | the relationship between primary colon cancer and occult nodal metastases (oms) detected by cytokeratin immunohistochemistry (ck-ihc) is unknown. we sought to investigate the correlation of clinicopathologic features of colon cancer with oms and to identify predictors of om. | 2010 | 20116081 |
| loss of udp-galnac:polypeptide n-acetylgalactosaminyltransferase 3 and reduced o-glycosylation in colon carcinoma cells selected for hepatic metastasis. | o-glycosylation of mucin is initiated by the attachment of n-acetyl-d-galactosamine (galnac) to serine or threonine residues in mucin core polypeptides by udpgalnac:polypeptide n-acetylgalactosaminyltransferases (ppgalnac-ts). it is not well understood how galnac attachment is regulated by multiple ppgalnac-ts in each cell. in the present study, the expression levels of murine ppgalnac-ts (mgalnac-ts), t1, t2, t3, t4, t6, and t7 were compared between mouse colon carcinoma colon 38 cells and vari ... | 2010 | 20077002 |
| systemic thyroid hormone is necessary and sufficient to induce ultraviolet-sensitive cone loss in the juvenile rainbow trout retina. | rainbow trout possess ultraviolet-sensitive (uvs) cones in their retina that degenerate naturally during development. this phenomenon can be induced with exogenous thyroxine [t4, a thyroid hormone (th)] treatment. however, the previous t4 exposure experiments employed static water immersion; a method that could introduce confounding stress effects on the fish. because of this, it was uncertain if t4 alone was sufficient to induce retinal changes or if stress-related hormones were also necessary ... | 2010 | 20086135 |
| advances in the relationship between lymph node status and prognosis: comment on "association between a high number of isolated lymph nodes in t1 to t4 n0m0 colorectal cancer and the microsatellite instability". | 2010 | 20088097 | |
| effect of melatonin supplementation on plasma vasopressin response to different conditions in rats with hyperthyroidism induced by l-thyroxine. | the present study was performed to determine how basal, isotonic, hypertonic and hypovolemic conditions affect fluid-electrolyte balance and plasma arginine vasopressin (avp) levels in rats with experimental hyperthyroidism supplemented with melatonin. the rats were divided into four groups of twenty-four subjects each kept under the following treatments during one month: (1) controls; (2) treated with l-thyroxine; (3) treated with l-thyroxine and sham melatonin and (4) treated with l-thyroxine ... | 2010 | 20079381 |
| micron-scale holes terminate the phage infection cycle. | holins are small phage-encoded proteins that accumulate harmlessly in the cytoplasmic membrane during the infection cycle until suddenly, at an allele-specific time, triggering to form lethal lesions, or "holes." in the phages lambda and t4, the holes have been shown to be large enough to allow release of prefolded active endolysin from the cytoplasm, which results in destruction of the cell wall, followed by lysis within seconds. here, the holes caused by s105, the lambda-holin, have been captu ... | 2010 | 20080651 |
| childhood minimally invasive follicular carcinoma: clinical features and immunohistochemistry analysis. | to report on two cases of childhood thyroid minimally invasive follicular carcinoma (mifc) to highlight the clinical features, laboratory findings and diagnosis of this rare disease. | 2010 | 20105250 |
| should direct mesocolon invasion be included in t4 for the staging of gastric cancer? | one of the sites most frequently invaded by gastric cancer is the mesocolon; however, the uicc does not mention this anatomical site as an adjacent structure involved in gastric cancer. the purpose of this study was to characterize and classify mesocolon invasion from gastric cancer. | 2010 | 20082356 |
| [paraplegia after prolonged cardiac arrest and extracorporeal life support]. | paraplegia by medullar ischaemia after cardiac arrest is rarely reported, especially without an oxo-ischaemic cerebral lesions. we report the case of a 17-year-old woman who underwent a 70 minute cardiac arrest with recovery of consciousness, but a symptomatic medullar ischaemia (paraplegia under t4). | 2010 | 20106627 |
| genetics and phenomics of selenoenzymes--how to identify an impaired biosynthesis? | expression of selenoenzymes relies on the se supply and specific cis- and trans-acting factors. two inherited defects are caused by dysfunctional selenoproteins or insufficient biosynthesis, i.e., selenoprotein n-related myopathy and impaired selenoprotein translation secondary to hypomorphic mutations in sbp2. the latter affects biosynthesis of many selenoenzymes including the deiodinase activities. a strategy to identify individuals carrying a mutation in a specific selenoprotein gene can be b ... | 2010 | 20083162 |
| thyroid hormone prevents cognitive deficit in a mouse model of alzheimer's disease. | this study aimed to examine the feasibility of using thyroid hormone (th) as a therapeutic agent for alzheimer's disease (ad). mice were injected intra-hippocampally aggregated amyloid beta-peptide (abeta) to produce ad animal model. intraperitoneal administration of l-thyroxine (l-t4) into abeta-induced ad model mice prevented their cognitive impairment and improved their memory function. the mechanisms of l-t4 treating ad might be associated with regulating cholinergic function, protecting the ... | 2010 | 20045708 |
| the effect of alcohol consumption on later obesity in early adulthood--a population-based longitudinal study. | the study aimed to determine whether alcohol use during late adolescence contributes to the weight gain from adolescence to young adulthood or risk of obesity or waist circumference at young adulthood. | 2010 | 20071348 |
| evaluation of isotope-coded protein labeling (icpl) in the quantitative analysis of complex proteomes. | an evaluation of the icpl (isotope-coded protein labeling) non-isobaric labeling technique was performed using two different biological models. two samples containing phage t4 capsids were mixed in a 1:1 ratio after being labeled with the light or heavy versions of the icpl reagent. the analysis of this proteome demonstrated the feasibility of this approach for differential quantitative proteomics and was employed to optimize the experimental parameters of the icpl workflow. icpl-mediated analys ... | 2010 | 20082807 |
| the star chart to ta bladder cancer: an unsophisticated analysis of two-dimensional gel electrophoresis proteome maps. | to explore the use of two-dimensional gel electrophoresis (2de) for analysing the proteome of clinically relevant tissue samples such as biopsies from transurethral resections of the bladder (turb), by generating a ta proteome map, possibly identifying technical or biological artefacts, and searching for biological subgroups associated with clinical data. | 2010 | 20059407 |
| association between a high number of isolated lymph nodes in t1 to t4 n0m0 colorectal cancer and the microsatellite instability phenotype. | stage i or ii colorectal carcinomas with microsatellite instability (msi) are characterized by more isolated lymph nodes in the resected specimen than their counterparts with microsatellite stability (mss). | 2010 | 20083749 |
| influence of class m1 glutathione s-transferase (gst mu) polymorphism on gst m1 gene expression level and tumor size in oral squamous cell carcinoma. | glutathione s-transferases (gst) are antioxidant enzymes and oxidative stress markers in oral carcinogenesis. they present a system of polymorphic proteins. some variants are associated with increased sensitivity to toxic compounds, as it is known for the gstm1-null variant allele. however, the influence of the gstm1 allele variant genotype on gstm1-mrna quantity in oral squamous cell carcinoma (oscc) and normal mucosa as well as the impact on prognosis remains unclear. the genotype for gstm1 (m ... | 2010 | 20060357 |
| novel multifunctional pharmaceutical excipients derived from microcrystalline cellulose-starch microparticulate composites prepared by compatibilized reactive polymer blending. | the choice of excipients remains a critical factor in pharmaceutical formulations. microcrystalline cellulose-maize starch composites (mcc-mst) have been prepared by mixing colloidal dispersions of microcrystalline cellulose (mcc) with 10% (w/w) of chemically gelatinized maize starch (mst) at controlled temperature conditions for use as multifunctional excipients with direct compression and enhanced disintegration abilities. the novel excipient was evaluated for its direct compression and enhanc ... | 2010 | 20060448 |
| [prophylactic irradiation of cervical lymph nodes for stage-n0 nasopharyngeal carcinoma]. | it is controversial for the irradiation level and dose of the regional prevention for naspharyngeal cancer (npc) with one or both cervical lymph node-negative neck. the study was to analyze the proophylactic irradiation of cervical lymph nodes for stage -n0 npc patients. | 2010 | 20038321 |
| is elective irradiation to the lower neck necessary for n0 nasopharyngeal carcinoma? | to summarize our experience and treatment results in lymph node-negative nasopharyngeal carcinoma treated in a single institution. | 2010 | 20044215 |
| genotyping of acanthamoeba isolates and clinical characteristics of patients with acanthamoeba keratitis in china. | acanthamoeba keratitis (ak) is a sight-threatening corneal infection, the epidemiology of which is related to the specific genotype of acanthamoeba. in this study, the genotypes of 14 acanthamoeba isolates, each from a patient with ak, were identified according to the highly variable df3 region in the 18s rrna gene at shandong eye institute, pr china, from 2000 to 2009, and the clinical characteristics of these patients were analysed. all 14 amoebae were genotype t4, representing nine different ... | 2010 | 20056772 |
| dna crunching by a viral packaging motor: compression of a procapsid-portal stalled y-dna substrate. | many large double-stranded dna viruses employ high force-generating atp-driven molecular motors to package to high density their genomes into empty procapsids. bacteriophage t4 dna translocation is driven by a two-component motor consisting of the procapsid portal docked with a packaging terminase-atpase. fluorescence resonance energy transfer and fluorescence correlation spectroscopic (fret-fcs) studies of a branched (y-junction) dna substrate with a procapsid-anchoring leader segment and a sin ... | 2010 | 20060554 |
| parental bonding and self-esteem as predictors of severe depressive symptoms: a 10-year follow-up study of norwegian physicians. | elevated rates of suicide and depression among physicians have been reported. the associations between perceived parental bonding and depressive symptoms have yet to be studied longitudinally in this occupational group. in a nationwide cohort, we sought to study parental bonding as a predictor for severe depressive symptoms and to determine whether self-esteem mediates this relationship. after graduation (t1), medical students (n = 631) were followed-up after 1 (t2), 4 (t3), and 10 (t4) years. t ... | 2010 | 20061865 |
| analytic review: thyrotoxic periodic paralysis: a review. | thyrotoxic periodic paralysis (tpp) is an unusual complication of hyperthyroidism that frequently presents in a dramatic fashion, necessitating treatment in an emergency department or admission to an intensive care unit. thyrotoxic periodic paralysis is characterized by transient, recurrent episodes of flaccid muscle paralysis affecting proximal more severely than distal muscles. thyrotoxic periodic paralysis is most commonly a complication of graves' disease in asian males, although in recent d ... | 2010 | 20089526 |
| outcomes after stereotactic lung radiotherapy or wedge resection for stage i non-small-cell lung cancer. | purpose to compare outcomes between lung stereotactic radiotherapy (sbrt) and wedge resection for stage i non-small-cell lung cancer (nsclc). patients and methods one hundred twenty-four patients with t1-2n0 nsclc underwent wedge resection (n = 69) or image-guided lung sbrt (n = 58) from february 2003 through august 2008. all were ineligible for anatomic lobectomy; of those receiving sbrt, 95% were medically inoperable, with 5% refusing surgery. mean forced expiratory volume in 1 second and diff ... | 2010 | 20065181 |
| bacteriophage adsorption efficiency and its effect on amplification. | existing models for bacteriophage adsorption are modified with the addition of a new term, adsorption efficiency, and applied to a t4-escherichia coli system. the adsorption efficiency is the fraction of phage that adsorbs irreversibly to the host. adsorption kinetics were modeled using the adsorption rate constant(k) and the adsorption efficiency(epsilon). experimental data demonstrated that the adsorption rate constant depends strongly on the condition of the host while the adsorption efficien ... | 2010 | 20066440 |
| [care continuity for patients with congenital hypothyroidism during transition from childhood to adulthood]. | since the nation-wide neonatal screening programs for congenital hypothyroidism(ch) had been implemented in 1979, the diagnosis and treatment of ch are now provided in the first 2-3 weeks of birth in japan. the goals of treatment are to raise the serum t4 as rapidly as possible into the normal range, and maintain normal growth and development while avoiding overtreatment. because transient hypothyroidism may occur frequently, a reevaluation after 3 years is needed in such patients. patients with ... | 2010 | 20077804 |
| painless thyroiditis complicated by acromegaly. | the serum thyroid stimulating hormone (tsh) level is decreased in acromegalic patients. although this phenomenon is thought to be caused by the enhanced secretion of somatostatin which suppresses tsh production, it has not yet been proven. we describe a 60-year-old woman with acromegaly who showed a low concentration of tsh. we diagnosed her as painless thyroiditis based on an increased level of thyroglobulin, depressed radioactive iodine uptake (raiu), normal vascularity and mild swelling of th ... | 2010 | 20075583 |
| characterizing the in vitro hepatic biotransformation of the flame retardant bde 99 by common carp. | polybrominated diphenyl ethers (pbdes) are a class of flame retardant chemicals known to biomagnify in aquatic foodwebs. however, significant biotransformation of some congeners via reductive dehalogenation has been observed during in vivo and in vitro laboratory exposures, particularly in fish models. little information is available on the enzyme systems responsible for catalyzing this metabolic pathway in fish. this study was undertaken to characterize the biotransformation of one primary bde ... | 2010 | 20080306 |
| sympathetic nervous system effects in the hands following a grade iii postero-anterior rotatory mobilisation technique applied to t4: a randomised, placebo-controlled trial. | joint mobilisation to the t4 vertebra has been advocated as a treatment for t4 syndrome. to date no controlled studies have investigated the effects of thoracic spinal manual therapy (smt) applied to t4 on sympathetic activity in the hands. this study investigated whether a grade iii postero-anterior rotatory joint mobilisation technique applied to the t4 vertebra at a frequency of 0.5 hz had demonstrably greater effects than a validated placebo intervention on skin conductance (sc) in the hands ... | 2010 | 20093065 |
| development of tefs for pcb congeners by using an alternative biomarker--thyroid hormone levels. | polychlorinated biphenyls (pcbs) are ubiquitous toxic contaminants. health risk assessment for this class of chemicals is complex: the current toxic equivalency factor (tef) method covers dioxin-like (dl-) pcbs, dibenzofurans, and dioxins, but excludes non-dl-pcbs. to address this deficiency, we evaluated published data for several pcb congeners to determine common biomarkers of effect. we found that the most sensitive biomarkers for dl-non-ortho-pcb 77 and pcb 126 are liver enzyme (e.g., ethoxy ... | 2010 | 20043972 |
| using the rate of respiration to monitor events in the infection of escherichia coli cultures by bacteriophage t4. | the growing interest in applications of bacteriophages creates a need for improvements in the production processes. continuous monitoring of the phage production is an essential aspect of any control strategy and, at present, there is no completely satisfactory option. the approach presented here uses ir-spectrometry to continuously measure the rate of respiration (co(2) released) of escherichia coli infected by phage t4 at various multiplicities of infection (moi). within the trends in these da ... | 2010 | 20039436 |
| short-term in-home intervention reduces depressive symptoms in early head start latina mothers of infants and toddlers. | depressive symptoms may compromise the ability of low-income latina mothers with limited english language proficiency to parent their infants or toddlers. eighty early head start latina mothers with limited english language proficiency were randomized to an advanced practice nurse-delivered, culturally tailored, in-home psychotherapy intervention, or to usual care. repeated measures regression analysis showed a significantly greater decrease in depressive symptoms for intervention mothers compar ... | 2010 | 20043296 |
| lipid profiles in the untreated patients with hashimoto thyroiditis and the effects of thyroxine treatment on subclinical hypothyroidism with hashimoto thyroiditis. | to evaluate the prevalence of dyslipidemia in the population of hashimoto thyroiditis, we reviewed medical records on the consecutive 1181 cases with adult hashimoto thyroiditis and 830 cases were adopted for the study. first, the serum tsh level increased and serum free t4 level decreased, slightly but significantly, with increasing age. there were significant positive correlations between serum tsh levels and lipid parameters such as total cholesterol (tc), triglyceride (tg), hdl-cholesterol ( ... | 2010 | 20032565 |
| optimum lymphadenectomy for esophageal cancer. | using worldwide esophageal cancer collaboration data, we sought to (1) characterize the relationship between survival and extent of lymphadenectomy, and (2) from this, define optimum lymphadenectomy. | 2010 | 20032718 |
| video. endoscopic minimally invasive thyroidectomy: first clinical experience. | since theodor kocher reduced the mortality rate of thyroidectomy from the 40% reported by billroth to 0.2% in 1895, a collar incision with open removal of the thyroid gland is the standard procedure. in the past decade, efforts were made to reduce incision size and surgical access trauma by the use of endoscopic techniques. a first attempt was replacement of the central "kocher incision" with lateral neck incisions and endoscopic removal of a thyroid lobe by hüscher on 8 july 1996. this lateral ... | 2010 | 20035350 |
| mesotrypsin promotes malignant growth of breast cancer cells through shedding of cd109. | serine proteases have been implicated in many stages of cancer development, facilitating tumor cell growth, invasion, and metastasis, and naturally occurring serine protease inhibitors have shown promise as potential anticancer therapeutics. optimal design of inhibitors as potential therapeutics requires the identification of the specific serine proteases involved in disease progression and the functional targets responsible for the tumor-promoting properties. here, we use the hmt-3522 breast ca ... | 2010 | 20035377 |
| influence of persistent thyroxine reduction on spermatogenesis in rats neonatally exposed to 2,2',4,4',5,5'-hexa-chlorobiphenyl. | the aim of the present study is to determine the long-term testicular effects of neonatal exposure to pcb153. | 2010 | 20025066 |
| breast cancer with non-inflammatory skin involvement: current data on an underreported entity and its problematic classification. | we evaluated 166 breast cancer cases with non-inflammatory skin involvement (nisi), which were classified in the tnm classification as t4b. the distribution of tumour sizes and stages was: < or =3 cm:24.1%, 3.1-5 cm:21.7%, 5.1-10 cm:33.1%, >10 cm:21.1%; stages:i/ii:21.0%, iii:43.4%, iv:35.6%. to assess the impact of nisi on axillary lymph node involvement (alni), we analyzed a sub-group of 50 patients with tumours < or =5 cm and compared them with a matched control group. nisi was found to be as ... | 2010 | 20015652 |
| does recombinant human thyrotropin-stimulated positron emission tomography with [18f]fluoro-2-deoxy-d-glucose improve detection of recurrence of well-differentiated thyroid carcinoma in patients with low serum thyroglobulin? | thyrotropin (tsh) stimulates thyrocyte metabolism, glucose transport, and glycolysis. the interest in using recombinant human tsh (rhtsh) stimulation of fluoro-2-deoxy-d-glucose (fdg) with positron emission tomography (pet) has been shown, but mainly for patients with high serum thyroglobulin (tg) concentration. we evaluated the use of rhtsh-stimulated pet-fdg in patients with low serum tg concentration. | 2010 | 20017617 |
| characterization of spinal afferent neurons projecting to different chambers of the rat heart. | the pattern of distribution of spinal afferent neurons (among dorsal root ganglia-drgs) that project to anatomically and functionally different chambers of the rat heart, as well as their morphological and neurochemical characteristics were investigated. retrograde tracing using a patch loaded with fast blue (fb) was applied to all four chambers of the rat heart and labeled cardiac spinal afferents were characterized by using three neurochemical markers. the majority of cardiac projecting neuron ... | 2010 | 20018227 |