Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| concordance between serology and 13c-urea breath test in the diagnosis of helicobacter pylori infection. | 1994 | 8122674 | |
| antral intestinal metaplasia in helicobacter pylori gastritis. | the prevalence of antral intestinal metaplasia (im) in underlying helicobacter pylori (hp) gastritis was studied in biopsy specimens of the antral mucosa obtained from 2,692 patients with histologically proven hp gastritis. the prevalence of im varied in the groups investigated: 47.4% in gastric ulcers, 30.5% in pyloric ulcers, 16.8% in duodenal ulcers, 21.8% in gastritis with no lesions and 9.8% in chronic antral erosions (p < 0.001). a hypothetical model for the role of hp in the development o ... | 1994 | 8112491 |
| role of helicobacter pylori eradication in the prevention of peptic ulcer bleeding relapse. | the objective of the present work was to determine the effect of treating helicobacter pylori infection on the recurrence of peptic ulcer bleeding. we prospectively followed 66 out of 70 consecutive h. pylori-positive (histology and/or culture) patients with conservatively and endoscopically managed peptic ulcer bleeding (duodenal ulcer; n = 39, gastric ulcer: n = 25, gastroduodenal double ulcer: n = 2) for a median period of 17 months (range 6-33 months). patients were treated in seven differen ... | 1994 | 8112492 |
| [the pathomorphosis of opisthorchiasis]. | based on the data available in the literature and their own findings, the authors have come to the conclusion that the clinical picture of opisthorchiasis has undergone profound changes in the past decades, which may be regarded as a manifestation of induced and reduced pathomorphism. uninduced pathomorphism appears as decreased invasion rates and as acute forms. induced pathomorphism shows up in reduced invasion or by timely liquidation of invasion. the etiological and pathogenetic role of heli ... | 1994 | 8015519 |
| diet, helicobacter pylori infection, food preservation and gastric cancer risk: are there new roles for preventative factors? | risks for gastric cancer in relation to diet and other environmental factors are receiving renewed attention. new developments include the emerging relationship between helicobacter pylori infection and an increased risk for gastric cancer, and positive results of chemoprevention trials in decreasing gastric cancer risk with the use of beta-carotene and vitamin e supplements. factors that may enhance risk include consumption of nitrites, nitrates, alcohol, and highly salted, pickled, fermented, ... | 1994 | 8015750 |
| [microbiological diagnosis of helicobacter pylori infection]. | 1994 | 8054368 | |
| [seroepidemiology, diagnosis, and post-treatment serologic follow-up of helicobacter pylori infection]. | 1994 | 8054369 | |
| [treatment of helicobacter pylori infection in adults]. | 1994 | 8054370 | |
| [treatment of helicobacter pylori infection in children]. | 1994 | 8054371 | |
| [epidemiology of helicobacter pylori infections]. | 1994 | 8054372 | |
| increasing prevalence of helicobacter pylori infection with age: continuous risk of infection in adults rather than cohort effect. | it remains unclear whether acquisition of helicobacter pylori is due to a continuous risk of acquiring the infection or a cohort effect. in this prospective 3-year cohort study, the seroprevalence, conversion, and reversion of h. pylori infection as determined by igg antibodies was examined. the cohort consisted of 316 randomly selected, nonpatient subjects aged 18-72 years who each provided at least 2 suitable samples. seroprevalence of h. pylori increased from 21% in the third decade to 50% in ... | 1994 | 8106778 |
| helicobacter pylori: a predominantly childhood infection--predominantly adult disease. | it is now 12 years since helicobacter pylori was first cultured in an australian laboratory. during these years significant understanding of the organism, its epidemiology and its disease associations have been made. diagnostic methods and therapeutic regimens have appeared and been refined. in this article microbiological, epidemiological and clinical aspects of adult and childhood h. pylori are linked to present and future public health problems. | 1994 | 8085444 |
| minimal access gastroduodenal surgery. | considerable advances are occurring in the application of laparoscopic techniques to gastrointestinal and hepatobiliary disorders. following studies in experimental animals, surgeons with an interest in gastroduodenal disease have now introduced laparoscopic techniques into current surgical practice. elective intervention for peptic ulcer disease is currently being established, particularly in patients with proven negative helicobacter pylori (hp) status, or when eradication has proved unsuccess ... | 1994 | 8085971 |
| the gastric cardia in helicobacter pylori infection. | helicobacter pylori gastritis is believed to be both more prevalent and more severe in the antrum than in the corpus. the mucosa of the cardia is architecturally similar to that of the antrum. this study was designed to test the hypothesis that intensity of h pylori infection and the associated inflammation are similar in the cardia and the antrum and are greater in these locations than in the corpus. a total of 445 gastric biopsy specimens were obtained from predetermined sites from 50 subjects ... | 1994 | 8088767 |
| ultrastructural study of two patterns in the interaction of helicobacter pylori with neutrophils. | as evidenced by electron microscopy, unopsonised bacteria of some helicobacter pylori strains were readily taken into cytoplasmic vacuoles of human neutrophils; those of other strains were only rarely absorbed. the strains engulfed like this also induced strong oxidative burst reactions in neutrophils, as measured by chemiluminescence. this has been associated with peptic ulcer disease, in the past. the ultrastructural interaction patterns agreed with the reaction patterns shown by chemiluminesc ... | 1994 | 8089228 |
| [evaluation of polymerase chain reaction for diagnosis of helicobacter pylori infection]. | to evaluate diagnostic tests of helicobacter pylori (h. pylori), we compared polymerase chain reaction (pcr) for the specific detection of h. pylori, culture and positivity of serum antibody against the bacteria in 59 patients with gastroduodenal disease. pcr assay was designed to amplify 203bp of dna fragments. pcr detected 10pg of h. pylori dna, or 40 cfu of the bacteria. pcr was positive in 82.1% of histological gastritis with neutrophil infiltration. culture and serum antibody to h. pylori w ... | 1994 | 8089913 |
| [helicobacter pylori resistance against metronidazole in switzerland: implications for eradication therapy?]. | gastroduodenal ulcers are strongly associated with helicobacter pylori (hp) infection. successful eradication drastically diminishes ulcer recurrence. most of the eradication schemes include metronidazole (flagyl). the present study was designed to establish the metronidazole resistance rate in switzerland. antral biopsies were taken in 153 patients with suspected ulcers (115 men, 38 women, mean age 46 +/- 16 [sd] years) during upper endoscopy for bacteriological testing. metronidazole resistanc ... | 1994 | 8091165 |
| [eradication of metronidazole-resistant helicobacter pylori: is omeprazole/amoxicillin a therapeutic alternative?]. | recommended therapies with the highest eradication rates for helicobacter pylori (hp) are triple therapies comprising bismuth salts, nitroimidazole and amoxicillin or tetracycline. primary and secondary resistance of hp to nitroimidazole, however, represents a major problem of this treatment since it is the main cause of eradication failure. in these cases therapeutic regimes without nitroimidazole could prove more successful. high dose omeprazole/amoxicillin has been suggested as a simple and e ... | 1994 | 8091166 |
| [omeprazole/amoxicillin: improved eradication of helicobacter pylori in smokers because of n-acetylcysteine]. | colonization of helicobacter pylori (hp) beneath the protective film of gastric mucus enables the organism to survive in the hostile environment of the gastric mucosa. n-acetylcysteine (nac), a sulfhydryl compound with potent mucolytic activity, induces a reduction of gastric barrier mucus thickness of about 75% and reduces mucus viscoelasticity. we therefore tested the hypothesis whether better eradication results could be achieved by addition of nac to omeprazole/amoxicillin (ome/amox). 34 hp ... | 1994 | 8091167 |
| [omeprazole/amoxicillin: impaired eradication of helicobacter pylori in smoking but not in premedication with omeprazole]. | the efficacy of high dose omeprazole/amoxicillin (ome/amox) for eradication of helicobacter pylori (hp) is controversial. reported eradication rates range from 0% to 90%. different therapy schedules and unknown factors may be crucial; in particular, pretreatment with ome has been thought to endanger hp eradication by subsequent ome/amox. preliminary findings suggested that smoking may impair eradication with ome/amox. the aims of this study were (1) to establish whether hp eradication rates diff ... | 1994 | 8091168 |
| helicobacter pylori: the missing link in perspective. | helicobacter pylori, an organism responsible for a common human infection, may act as a cofactor to produce gastrointestinal disease in a significant minority. the exact mechanisms of transmission are still unclear, but likely involve direct person-to-person spread and fecal-oral or waterborne/environmental transmission. infection is a necessary condition for the development of duodenal ulcers and chronic nonspecific gastritis. it also likely contributes to the development of gastric ulcers, and ... | 1994 | 8092176 |
| [possibility of helicobacter pylori invasion into the lamina propria of the gastric mucosa]. | biopsies of the stomach antrum and fundus from 20 male patients with non-ulcer dyspepsia were studied light- and electron-microscopically. helicobacter pylori infection was found in 60% of cases. in 2 patients, the bacteria were found not only in the fovea and mucus, but in the tunica propria as well. the bacteria were observed in the dilated intercellular spaces of the epithelium, between epithelium and basal membrane as well as around the glands and capillaries in the form of colonies. in the ... | 1994 | 8092933 |
| [morphometrics and immunohistochemical characteristics of chronic gastroduodenitis in adolescents]. | mucous membrane of the antral region of the stomach and that of duodenum were studied in 36 teenagers, 21 of them had erosions revealed endoscopically and histologically. morphometric indices of the inflammation were more pronounced when erosions were present; the latter did not influence the local production of iga, igm and igg. the content of igg was particularly high. contamination with helicobacter pylori was found in all cases and was more pronounced in erosive gastroduodenitis. high freque ... | 1994 | 8092934 |
| [helicobacter pylori and stomach cancer]. | a review of the recent literature on the association between helicobacter pylori (hp) and stomach carcinoma (sc) is presented. it is established that sc occurs 6-8 times more frequently in persons infected with hp than in non-infected. hp is considered as a co-factor in the development of sc: hp stimulates proliferation of stomach epitheliocytes and is able to produce free radicals having mutagenic properties. some authors compare the role of hp in the development of sc with that of tobacco in t ... | 1994 | 8092936 |
| nucleotide sequence of the wolinella succinogenes flagellin, which contains in the antigenic domain two conserved regions also present in campylobacter spp. and helicobacter pylori. | wolinella succinogenes possesses one polar flagellum, which shows a characteristic surface pattern of parallel lines along the axis of the filament in electron microscopic images. we determined the gene sequence of the wolinella flagellin, which is, as in most other bacteria, the only structural component of the filament. sequence comparison with other members of the proteobacteria revealed two highly conserved regions in the central part of the flagellin molecule among campylobacter spp. and he ... | 1994 | 8051032 |
| serological detection of helicobacter pylori antibodies in children and their parents. | the antibody response to helicobacter pylori was examined in 56 children (ages 5 to 18) to determine whether serological tests can be used for diagnosis. twenty-four children (43%) were h. pylori positive and 32 children (57%) were h. pylori negative by culture and histological examination of endoscopic biopsy specimens. the immune response was also examined in 39 nonendoscoped parents of the children. h. pylori-specific immunoglobulin g (igg) and iga antibodies were detected by the flow microsp ... | 1994 | 8051244 |
| [helicobacter pylori and stomach cancer: "the signs should be traced all the way!"]. | 1994 | 8051996 | |
| [primary stomach lymphoma of the malt type. diagnosis and therapy. gastrointestinal lymphoma study group]. | primary gastric lymphoma are nowadays considered as a distinct lymphoma entity. their classification is based on the concept of malt (mucosa-associated lymphoid tissue). within the gastrointestinal tract, the stomach is most frequently involved. in the pathogenesis of gastric lymphoma, helicobacter pylori-associated gastritis plays an important, conditioning role. usually, the diagnosis of gastric lymphoma can be established on the basis of endoscopic biopsies. endoscopic ultrasound seems highly ... | 1994 | 8052089 |
| helicobacter pylori: a fickle germ. | the morphologic changes from bacillary to coccoid forms of helicobacter pylori were studied. these form changes were analyzed by bacterial growth in brucella broth plus 2% fetal calf serum. the coccoid forms were observed at five days of incubation and a rapid decrease of cfu/ml was recorded. at two weeks of microaerophilic incubation, all coccoid forms observed were not culturable in vitro. the coccoid morphology was observed earlier when the culture of h. pylori was incubated in aerobic condit ... | 1994 | 8052159 |
| [endoscopic findings in volunteers and dyspeptic patients]. | although more than a fourth of the adult population reports dyspeptic complaints, little is known about the prevalence of clinically relevant ugi endoscopic findings in these patients in comparison with asymptomatic volunteers. this type of information is required in order to assess the relative risks of organic dyspepsia and the sensitivity and specificity of dyspeptic complaints for peptic lesions. in an attempt to fill this gap, the authors compared two trials carried out in the german-speaki ... | 1994 | 8052829 |
| helicobacter pylori: consensus reached: peptic ulcer is on the way to becoming an historic disease. | 1994 | 8053422 | |
| double-blind comparison of lansoprazole, ranitidine, and placebo in the treatment of acute duodenal ulcer. lansoprazole study group. | to study in a double-blind controlled manner the effects of lansoprazole 15 mg or 30 mg daily compared with ranitidine 300 mg once daily and placebo in the relieving of symptoms and healing of acute duodenal ulceration. | 1994 | 8053433 |
| clarithromycin, tetracycline, and bismuth: a new non-metronidazole therapy for helicobacter pylori infection. | metronidazole resistance has become an increasing problem that has limited the usefulness of the original triple therapy. our objective was to evaluate clarithromycin, a new macrolide compound active against helicobacter pylori. | 1994 | 8053435 |
| helicobacter pylori infection and serum pepsinogen a, pepsinogen c, and gastrin in gastritis and peptic ulcer: significance of inflammation and effect of bacterial eradication. | to study the relationship between helicobacter pylori infection, gastric inflammatory scores, and fasting gastrin and pepsinogen a and c concentrations, and to evaluate the effect of treatment on these parameters. | 1994 | 8053437 |
| the proton pump inhibitor omeprazole inhibits acid survival of helicobacter pylori by a urease-independent mechanism. | 1994 | 8076759 | |
| the acquisition of helicobacter pylori infection: good news for western societies? | 1994 | 8076782 | |
| age-related prevalence of helicobacter pylori antibodies in indian subjects. | to determine the age-related prevalence of helicobacter pylori antibodies in indian subjects without upper gastrointestinal symptoms. | 1994 | 8076989 |
| evaluation of three commercially available blood culture systems for cultivation of helicobacter pylori. | helicobacter pylori is unable to grow in regular blood culture systems, including the bactec (johnston laboratories), septi-chek (hoffman-la roche), and bacto (difco) systems. we tested three blood culture systems used for fastidious organisms: brucella broth with sps and co2 (becton dickinson), biphasic brain heart infusion agar or broth (becton dickinson), and supplemented peptone broth (vacutainer). blood culture bottles were inoculated with h. pylori and human blood and were then incubated b ... | 1994 | 8077412 |
| hepatitis a and evidence against the community dissemination of helicobacter pylori via feces. | seroprevalence data from 1501 subjects was used to test the hypothesis that helicobacter pylori may be transmitted by the fecal-oral route. antibody to hepatitis a virus was used as a marker of fecal-oral exposure. of the 1501 subjects, 35.5% were seropositive for both h. pylori and hepatitis a, 19.1% were seronegative for both, 36.5% were seropositive for hepatitis a only, and 8.8% were seropositive for h. pylori only. cross-sectional data from rural areas supported an association between hepat ... | 1994 | 8077729 |
| does disordered upper gastrointestinal motility predispose to helicobacter pylori colonization of the stomach in children? | helicobacter pylori is an important factor in the pathogenesis of chronic gastritis and gastroduodenal ulcer disease. however, the basic causal mechanisms of h pylori colonization on the gastric mucosa are still unclear. the authors evaluated the prevalence of h pylori colonization in 266 children who underwent upper gastrointestinal endoscopy during a 12-month period. the indications for endoscopy were follow-up of esophagitis related to gastroesophageal reflux (n = 17), suspicion of gastroesop ... | 1994 | 8078008 |
| helicobacter pylori alcohol dehydrogenase in perspective: an interesting finding of doubtful clinical significance. | 1994 | 8079102 | |
| dyspepsia in general practice: history and symptoms in relation to helicobacter pylori serum antibodies. | this study was designed to explore the relationships between serologic helicobacter pylori positivity and demographic, behavioural, and symptomatologic factors in patients consulting for dyspeptic symptoms in general practice. | 1994 | 8079107 |
| helicobacter pylori in functional dyspepsia and normal controls. | the aim of this study was to examine whether helicobacter pylori status can identify a specific subset of patients with functional dyspepsia (fd) and erosive prepyloric changes (epc). | 1994 | 8079110 |
| effect of bismuth and nitecapone on acetaldehyde production by helicobacter pylori. | we have recently shown that colloidal bismuth subcitrate inhibits cytosolic alcohol dehydrogenase of helicobacter pylori as well as acetaldehyde production from excess ethanol. we now extend our studies to bismuth subsalicylate and nitecapone, a novel antiulcer agent. | 1994 | 8079111 |
| risk of recurrence of gastric ulcer, chronic gastritis, and grade of helicobacter pylori colonization. a long-term follow-up study of 25 patients. | we describe here our observations on colonization of the gastric mucosa by helicobacter pylori in a long-term follow-up of 25 patients with gastric ulcer (gu). | 1994 | 8079112 |
| [alternative treatment of helicobacter pylori infections]. | 1994 | 8079238 | |
| [psychosocial factors in patients with duodenal ulcer]. | the authors review the current literature on psychosocial aspects of duodenal ulcer. the initial simple psychosomatic approach, has evolved to a multifactorial schema in which stress and individual vulnerability plays an important role. psychological features (personality, type a behaviour, alexithymia, anxiety, depression) and socioenvironmental factors (stress, life events, coping, social support) are analyzed. newer aspects like the probable stress influence on immunity and infection by helic ... | 1994 | 8079675 |
| some of the factors that may mediate or modify the gastrointestinal mucosal damage induced by non-steroidal anti-inflammatory drugs. | numerous factors are involved in the gastrointestinal mucosal damage induced by non-steroidal anti-inflammatory drugs. the physico-chemical-acidic-property of the drugs is responsible partly for the rapid absorption, mucosal accumulation and barrier breaking effect, partly for the topical irritant action. the drugs decrease the defensive mechanisms of the stomach at different level, destroy the mucosal barrier, decrease the surface hydrophobicity, the mucosal blood flow, and inhibit the prostagl ... | 1994 | 8079824 |
| triple therapy with sucralfate is not effective in eradicating helicobacter pylori and does not reduce duodenal ulcer relapse rates. | the most used therapeutic schedule to eradicate helicobacter pylori is the "triple therapy," which is based on the simultaneous use of a bismuth salt and two antibiotics. sucralfate, a basic aluminum salt of sucrose sulfate, is supposed to have an antibacterial activity and is said to reduce the bacterial density of h. pylori. this randomized, prospective clinical trial compares the efficacy of an alternative oral triple therapy consisting of sucralfate, tinidazol, and tetracycline with a conven ... | 1994 | 8079927 |
| helicobacter pylori and refractory duodenal ulcers: cross-over comparison of continued cimetidine with cimetidine plus antimicrobials. | to determine the distribution of helicobacter pylori in the antral and duodenal mucosa of patients with duodenal ulcers refractory to 12 wk of treatment with cimetidine and to evaluate the effect of adding antimicrobial agents to cimetidine on the healing of refractory duodenal ulcers. | 1994 | 8079928 |
| effect of eradication of helicobacter pylori on serum pepsinogen i, gastrin, and insulin in duodenal ulcer patients: a 12-month follow-up study. | to understand the short-term and long-term effects of the eradication of helicobacter pylori on serum pepsinogen i, gastrin, and insulin concentration, we studied 53 patients with endoscopically proven duodenal ulceration and h. pylori infection. | 1994 | 8079929 |
| resolution of protein-losing hypertrophic lymphocytic gastritis with therapeutic eradication of helicobacter pylori. | lymphocytic gastritis (lg) is a recently described histological entity characterized by increased lymphocytes in the superficial gastric epithelium and foveolae. it includes a subgroup of patients with giant gastric folds and, often, a protein-losing state, a condition termed hypertrophic lymphocytic gastritis (hlg). despite close endoscopic and clinical similarities to classical menetrier's disease, the histopathological features of these two diseases are sufficiently distinct that they are reg ... | 1994 | 8079936 |
| short-term omeprazole oral/amoxicillin intravenous therapy for helicobacter pylori eradication: a lack of therapeutic effect. | 1994 | 8079960 | |
| helicobacter pylori in patients with rosacea. | 1994 | 8079962 | |
| ascorbic acid, helicobacter pylori and lewis phenotype among blacks and whites in new orleans. | gastric juice ascorbic acid concentrations were examined in black and white patients. significantly lower concentrations were found in blacks, in the absence of a significant difference in the plasma concentration of vitamin c between races. blacks had higher prevalence of helicobacter pylori infection, higher gastric ph, more severe acute and chronic inflammation of the gastric mucosa and higher frequency of lewis (a-b-) phenotype. although most of these factors have been related to low ascorbi ... | 1994 | 8080590 |
| helicobacter pylori: molecular basis for host recognition and bacterial adherence. | the bacterium helicobacter pylori is tropic for epithelial cells and the mucus layer in the stomach lining, and is associated with the development of gastritis, ulcers and possibly also gastric malignancies. adherence to the gastric epithelial cells is mediated by fucosylated blood-group antigens associated with blood-group o phenotype, which could explain the higher prevalence of ulcerative disease in individuals with this blood group. | 1994 | 8081648 |
| peptic ulcer surgery in 1994. | despite successful medical treatment of peptic ulcer disease regarding both acid reduction and eradication of helicobacter pylori, there is still an increasing number of emergency operations for complications and no decrease of mortality. elective surgery after complete physiologic work-up can improve the results for a certain group of patients. in cases requiring acid reduction only, laparoscopic procedures such as posterior truncal vagotomy and anterior seromyotomy can be offered. the minimal ... | 1994 | 8081937 |
| primary antral gastritis in young american children. low prevalence of helicobacter pylori infections. | although helicobacter pylori (h. pylori) is considered by many to be the major cause of primary antral gastritis (pag), several important questions concerning its pathogenetic role remain unanswered. the most basic unresolved issue relates to the low prevalence of h. pylori in children in developed countries. if h. pylori is the cause of pag, the prevalence of pag should also be low, but previous studies have not provided data on this issue. to answer this question, we prospectively studied 408 ... | 1994 | 8082491 |
| [total peptic activity in gastric juice in patients with duodenal ulcer. variations in relation to age and role of helicobacter pylori]. | the aim of this study was to evaluate total peptic activity in gastric juice in duodenal ulcer patients in relation to age and helicobacter pylori infection. in duodenal ulcer patients peptic activity increases significantly in comparison to normal subjects. in relation to age there is no variation. therefore, gastric secretion has an autonomous behaviour independently of any physiological variation in healthy subjects. helicobacter pylori infection is present in 89.4% of duodenal ulcer patients ... | 1994 | 8084432 |
| testing negative for helicobacter pylori after methylene blue spraying of gastric mucosa. | 1994 | 8056268 | |
| effectiveness of a five times daily triple therapy regimen against helicobacter pylori. | 1994 | 8056709 | |
| manifestation of symptoms in children infected with helicobacter pylori. | 1994 | 8057232 | |
| genetic analysis of the helicobacter pylori vacuolating cytotoxin: structural similarities with the iga protease type of exported protein. | the human gastric bacterial pathogen helicobacter pylori has been implicated in type b gastritis, peptic ulceration and gastric adenocarcinoma. here we report on the cloning and genetic characterization of an h. pylori gene named vaca, which encodes the vacuolating cytotoxin vaca, a novel type of antigenic bacterial toxin that induces the formation of intracellular vacuoles in epithelial cells. the vacuolating cytotoxin activity is expressed by a subset of clinical isolates (vac+), all of which ... | 1994 | 8057855 |
| helicobacter pylori and gastric lymphoma. | 1994 | 8058088 | |
| [helicobacter pylori and ulcer disease]. | 1994 | 8059463 | |
| difficulty in eradicating helicobacter pylori in a population at high risk for stomach cancer in venezuela. | the bacterium helicobacter pylori (hp) has been implicated in the etiology of precancerous lesions of the stomach and there is evidence suggesting that it may influence the efficacy of chemoprevention of gastric cancer with vitamin c. eradication seldom has been attempted in populations from developing countries, with a high prevalence of hp frequently resistant to metronidazole. a randomized, double-blind, controlled trial to evaluate the efficacy of colloidal bismuth subcitrate (120 mg q.i.d.) ... | 1994 | 8061173 |
| evaluation of two therapeutic regimens for the treatment of helicobacter pylori infection. | in the present study we evaluated the efficacy and tolerability of two different therapeutic schedules in eradicating helicobacter pylori. forty-six consecutive patients (suffering from either peptic ulcer or non-ulcer dyspepsia) with helicobacter pylori infection were randomly allocated to one of the following two groups: group 1 (n = 23) 2 weeks of treatment with bismuth subcitrate tablets (120 mgx4) + amoxycillin capsules (500 mgx4) + metronidazole tablets (250 mgx4); group 2 (n = 23) 2 weeks ... | 1994 | 8061335 |
| the role of helicobacter pylori in gastric carcinogenesis and in gastroduodenal disease. | 1994 | 8061588 | |
| helicobacter pylori: the link with gastric cancer. | gastric cancer is the world's overall second most common cancer, and carries a bad prognosis. in the correa model of gastric carcinogenesis, environmental factors (salt, nitrate, a lack of vitamin c and beta-carotene, bile reflux, bacterial overgrowth in atrophic gastritis with nitrosamine formation) are related to the evolution from normal gastric tissue through superficial gastritis, multifocal atrophic gastritis, intestinal metaplasia and dysplasia to carcinoma. the incidence of h. pylori dec ... | 1994 | 8061590 |
| chronic erosive gastritis on morphological analysis. | the present study was carried out to systematize the histopathological markers of chronic erosive gastritis referred to also as gastritis varioliformis (gv). the study population consisted of 74 patients aged 20 to 69 years with gastroscopic gv. the samples were obtained from the erosion site and representative areas of the prepyloric region and gastric body. in routine microscopic examinations we evaluated the severity, type and location of changes in the gastric mucosa. helicobacter pylori in ... | 1994 | 8062065 |
| human monoclonal antibodies from stomach carcinoma patients react with helicobacter pylori and stimulate stomach cancer cells in vitro. | in recent studies, an increased incidence of gastric adenocarcinomas was observed in patients with helicobacter pylori infection. however, the extent to which this coincidence is caused by immunologic mechanisms is unknown. | 1994 | 8062186 |
| assessment of four rapid urease test systems for detection of helicobacter pylori in gastric biopsy specimens. | an in vitro experiment and an in vivo clinical trial were both performed in order to assess the efficacy of four biopsy urease test systems, including one commercial kit, temmler cut test (temmler pharma, marburg, germany), for the rapid detection of helicobacter pylori. we first evaluated four rapid urease test systems by inoculating bacterial suspensions of different concentrations into urea-containing media and observing the color change at room temperature. we found that the cut test was sup ... | 1994 | 8062534 |
| predicting nsaid related ulcers--assessment of clinical and pathological risk factors and importance of differences in nsaid. | although ulcers are often associated with non-steroidal anti-inflammatory drugs (nsaids) little is known about the feasibility of predicting their development in patients taking nsaids. in addition, the ulcerogenic potentials of the newer nsaids, taken on long term basis, have not been compared with those of more established preparations. the aim of this study was to identify the clinical and pathological characteristics of patients at a higher risk of nsaid induced ulcers, measure the ulcerogen ... | 1994 | 8063215 |
| polymerase chain reaction assay for the detection of helicobacter pylori in gastric biopsy specimens: comparison with culture, rapid urease test, and histopathological tests. | ulcer recurrence is probably related to residual helicobacter pylori (h pylori). histological examination and culture are considered to be the most specific tests. clo test is a rapid but less specific test, which is usually used as an alternative test to culture. the aim of this study was to investigate the efficiency of a simplified polymerase chain reaction (pcr) assay as a procedure for the diagnosis of gastric h pylori infection of patients. biopsy specimens were obtained from antral mucosa ... | 1994 | 8063217 |
| effect of gastric ph on urease-dependent colonization of gnotobiotic piglets by helicobacter pylori. | thirty-seven gnotobiotic piglets from seven litters were infected with either helicobacter pylori n6 or urease-negative h. pylori n6ureg::km which contains an insertion in the ureg gene and produces inactive urease. to produce achlorhydria, piglets were treated throughout the experiment with omeprazole (5 mg intravenously every 12 h) and ranitidine (75 mg orally every 6 h). treatment resulted in elevation of gastric ph to 7.0 +/- 1.1 throughout the experiment. control piglets were not treated an ... | 1994 | 8063376 |
| interaction of lipopolysaccharides of helicobacter pylori with basement membrane protein laminin. | the ability of hemagglutinating and poorly hemagglutinating strains of the gastroduodenal pathogen helicobacter pylori to bind 125i-radiolabelled laminin was quantitated in a liquid phase assay. although all strains bound laminin, some hemagglutinating strains were good binders of laminin (maximum of 31% binding), whereas poorly hemagglutinating strains bound intermediate to small amounts of laminin (minimum of 6% binding). since a hydrophobic component of the bacterium has been reported to be i ... | 1994 | 8063380 |
| [the effect of superhigh-frequency electromagnetic radiation on the course of helicobacter pylori-associated peptic ulcer]. | the authors studied effects of microwave electromagnetic irradiation on the course of peptic ulcers and dissemination with helicobacter pylori in 60 patients with various severity of the disease. microwave irradiation not only hastens clinico-endoscopical remission of the disease but also considerably reduces dissemination of mucosa with helicobacter pylori. | 1994 | 8067031 |
| seroprevalence and associated risk factors of helicobacter pylori infection in taiwan. | in order to estimate the seroprevalence and explore multiple risk factors associated with helicobacter pylori infection among residents in taiwan, a total of 823 subjects randomly selected from one metropolitan precinct and three townships were studied. serum samples were tested for igg antibodies against h. pylori by enzyme-linked immunosorbent assay using commercial kits. the overall seropositive rate was 54.4% with no gender difference (53.7% for males and 55.2% for females). there was a sign ... | 1994 | 8067711 |
| the humoral immune response to helicobacter pylori infection in children with recurrent abdominal pain. | the systemic humoral immune response to helicobacter pylori antigens was investigated in 36 children with recurrent abdominal pain (rap). h. pylori was cultured and helicobacter-like organisms (hlo) were seen in six children, three of whom had active and two inactive chronic gastritis. none of these children had endoscopic abnormalities. all sex children had increased igg antibodies to heat-stable h. pylori antigens which were of the igg1 and igg3 subclasses. using six other igg tests, four of w ... | 1994 | 8068306 |
| culture of helicobacter pylori under aerobic conditions on solid media. | the aim of the present study was to culture helicobacter pylori under aerobic conditions and to investigate the characteristics of the organism when cultured aerobically. most (22 of 23) of the helicobacter pylori isolates grew under aerobic conditions, but with reduced viable cell counts. blood agar was more suitable than chocolate agar. the morphological and enzymatic characteristics as well as the protein profiles of each organism were identical under aerobic and microaerophilic conditions. h ... | 1994 | 8070454 |
| adaptation of helicobacter pylori to aerobic growth. | two of 23 strains of helicobacter pylori adapted from microaerobic to aerobic growth on blood agar plates incubated in humidified air. the air-adapted strains remained urease and phenylalanine deaminase positive and did not require the buffering effect of an enriched co2 atmosphere for growth. the significance of this phenomenon remains to be determined as the two strains capable of aerobic metabolism were laboratory-adapted. | 1994 | 8070455 |
| [optimal or maximum acid inhibition in ulcer therapy? a decision guide for routine general practice based on personal studies]. | the mucosal barrier in the stomach is complete only when the mucous layer has become saturated with bicarbonate. the latter arises as a waste product, as it were, of acid production in the parietal cell, but is then actively secreted via the surface epithelial cells and tight junctions. if the acid secretion is inhibited by means of drugs, the bicarbonate concentration also decreases. this situation probably occurs only when the bicarbonate batteries in the mucous layer and the surface epithelia ... | 1994 | 8070748 |
| duodenal ulcer treatment: progress from ph to hp. | the treatment of duodenal ulcer has evolved from ineffective medical treatments through an era of surgical management, back to increasingly effective medical treatment. the advent of h2-receptor antagonists changed the outlook for ulcer patients. more recently, helicobacter pylori, an organism which inhabits gastric mucosa exclusively, has been implicated in the pathogenesis of peptic ulcer. this bacterium is found in the stomachs of around 95% of duodenal ulcer patients. its eradication is show ... | 1994 | 8071396 |
| prevalence of helicobacter pylori in neonates and young infants undergoing ercp for diagnosis of neonatal cholestasis. | this study was carried out to determine the prevalence of helicobacter pylori infection in 20 neonates and young infants from lower socioeconomic background undergoing endoscopic retrograde cholangiopancreatography (ercp) examination for diagnosis of neonatal cholestasis. one young asymptomatic infant (5%) who was breast-feeding with complementary formula had h. pylori infection. endoscopy showed a normal appearing mucosa and histology demonstrated mild superficial acute gastritis. a follow-up g ... | 1994 | 8071783 |
| helicobacter pylori: trick or treat? | 1994 | 8071909 | |
| [importance of helicobacter pylori infection and pepsinogen titer in hemodialysis and renal transplantation patients in japan]. | helicobacter pylori (hp) infection is thought to play an important role in for the pathogenesis of atrophic gastritis and even gastric carcinoma. the ratio of pepsinogen i/ii (p i/ii) also shows good correlation with atrophic gastritis and gastric ulcer. since many hemodialysis (hd) and renal transplantation patients suffer from gastrointestinal problems, we investigated the importance of hp infection and p i/ii in these patients. serum hp igg was measured by eia. pepsinogen titer was measured w ... | 1994 | 8072224 |
| acetaldehyde and ethanol production by helicobacter pylori. | by virtue of possessing alcohol dehydrogenase activity, cytosol prepared from helicobacter pylori produces toxic acetaldehyde from ethanol in vitro. to approach the in vivo situation in the stomach, we have now investigation whether intact h. pylori--without addition of exogenous nicotinamide adenine dinucleotide--also forms acetaldehyde. furthermore, to assess the energy metabolism of h. pylori, we determined whether the alcohol dehydrogenase-catalyzed reaction can run in the opposite direction ... | 1994 | 8047804 |
| the role of helicobacter pylori in peptic ulcer disease. | there is now a persuasive body of evidence linking helicobacter pylori infection and peptic ulcer disease. over 90% of duodenal ulcer and 70% of gastric ulcer patients are infected with h. pylori. only a minority of infected patients develop ulcers, however, and host cofactors, rather than h. pylori strain, are probably critical to the development of peptic ulcer in infected individuals. conversely, not all ulcers are associated with h. pylori, and in these cases enterogastric reflux and non-ste ... | 1994 | 8047817 |
| the role of acid inhibition in the treatment of helicobacter pylori infection. | the recognition that helicobacter pylori is a causal factor in the development of most peptic ulcers (and may play a role in the pathogenesis of gastric cancer) has provided an impetus to the search for a suitable regimen that will eradicate the organism. combinations of antibiotics with bismuth (triple therapy) eradicate the organism in around 90% of cases, but the regimens are complicated, and poor compliance and significant side effects are frequently seen. the observation that omeprazole in ... | 1994 | 8047818 |
| the microbiology and epidemiology of helicobacter pylori infection. | helicobacter pylori is part of a genus of specialized bacteria that have adapted to the ecological niche provided by gastric mucus. h. pylori has exploited the human niche, while further species of helicobacter have inhabited the gastric mucosa of other animals. the preferred habitat of h. pylori is the gastric antrum. in humans with normal gastric function, the organism is mainly restricted to the antral surface, where a number of specialized traits allow it to flourish, while causing minimal h ... | 1994 | 8047819 |
| gastric cancer--a long-term consequence of helicobacter pylori infection? | chronic gastritis and chronic atrophic gastritis in particular are risk factors for gastric cancer. in western societies, for example finland, up to 70% of gastric cancer cases are associated with helicobacter pylori-positive chronic non-atrophic or atrophic gastritis, approximately 15% appear in conjunction with autoimmune chronic corpus-limited h. pylori-negative atrophic gastritis, and 15% develop in individuals with a histologically normal stomach. the role of h. pylori infection in chronic ... | 1994 | 8047820 |
| effects of eradication of helicobacter pylori on gastritis in duodenal ulcer patients. | the incidence and mean score of helicobacter pylori-related, active antroduodenitis, lesions of superficial antral epithelium and duodenal gastric-type metaplasia were higher in endoscopic biopsies from a large series of patients with duodenal ulcer, when compared with asymptomatic patients or patients with non-ulcer dyspepsia. in 65 out of 73 patients with duodenal ulcer who could be followed up, h. pylori was eradicated using a combination of amoxycillin, 3 g daily, metronidazole, 1 g daily, a ... | 1994 | 8047821 |
| emerging strategies for managing peptic ulcer disease. | the relationship between the inhibition of intragastric acidity and healing has been determined for both duodenal and gastric ulcers, with a stronger correlation being evident in duodenal ulcer. omeprazole is clearly more effective than h2-receptor antagonists in healing duodenal ulcers and in the resolution of attendant symptoms. as the recommended treatment periods are shorter with omeprazole (e.g. 2-4 weeks) than with h2-receptor antagonists (4-8 weeks), omeprazole has also been shown to be m ... | 1994 | 8047824 |
| pathophysiology of helicobacter pylori infection. | helicobacter pylori is now accepted as the major cause of chronic gastritis. the initial response to infection is acute neutrophilic gastritis, which progresses to active chronic gastritis in most people. to confirm the pathogenic role of h. pylori, both the individual histological features of chronic gastritis and its topographical patterns must be shown to be caused by the infection. surface epithelial degeneration is a probable result of direct tissue injury by bacterial products. candidates ... | 1994 | 8047828 |
| helicobacter pylori. | 1994 | 8048402 | |
| [functional dyspepsia, gastric emptying of solids, and helicobacter pylori infection]. | the origin of functional dyspepsia (fd) is unknown, however, abnormal gastric emptying and infection by h. pylori have been suggested as possible causes. | 1994 | 8049101 |
| familial clustering of helicobacter pylori infection. | 1994 | 8050260 | |
| helicobacter pylori is associated with alterations in intestinal gas profile among patients with nonulcer dyspepsia. | the pathogenesis of nonulcer dyspepsia (nud) is unknown. gas and postprandial bloating are frequent symptoms. the role of helicobacter pylori (hp) in the pathogenesis of nud is controversial. we studied the intestinal gas profile of nud patients (n = 34) at baseline and after lactulose administration. the prevalence of hydrogen and methane producers was similar among hp+ and hp- patients. breath h2 concentrations in response to lactulose showed significantly greater rise among hp+ subjects (p < ... | 1994 | 8050308 |
| helicobacter pylori in a costa rican dyspeptic patient population. | gastric biopsies from 65 costa rican dyspeptic patients were investigated for the presence of helicobacter pylori dna by polymerase chain reaction (pcr) amplification of 16s rrna sequences. both frozen and paraffin-embedded samples were used, and the results were compared with bacterial culture and histological examination. helicobacter pylori dna was detected by pcr in 60 (92%) of the patients, and helicobacter pylori strains confirmed by pcr could be isolated from 37 of them. altogether, 59 pa ... | 1994 | 8050440 |
| [prevention of duodenal ulcer recurrence with penicillin]. | the aim of this study was to test the hypothesis that infection with helicobacter pylori is essential for recurrence of duodenal ulcer. we performed a randomized controlled trial of the relapse rate of duodenal ulcer during 12 weeks treatment with penicillin v or placebo in 170 out-patients from five centres. the relapse rate was 9% during treatment with penicillin and 50% with placebo, p < 0.0001. it is concluded that infection with penicillin-sensitive bacteria, i.e. h. pylori, plays an import ... | 1994 | 8016944 |