Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| antibiotic-resistant propionibacterium acnes on the skin of patients with moderate to severe acne in stockholm. | the objective was to study the prevalence and antibiotic susceptibility patterns of propionibacterium acnes strains isolated from patients with moderate to severe acne in stockholm, sweden and to determine the diversity of pulsed-field gel electrophoresis types among resistant p. acnes strains. one hundred antibiotic-treated patients and 30 non-antibiotic-treated patients with moderate to severe acne participated in the investigation. facial, neck and trunk skin samples were taken with the agar ... | 2004 | 16701513 |
| lasers alleviate acne. | propionibacterium acnes (p. acnes) and sebaceous glands are involved in the pathogenesis of acne. although often effective, traditional therapies can have drawbacks, such as photosensitivity, other toxicities, polypharmacy and frequent dosing. lasers have been studied to seek a solution that may overcome these disadvantages. lasers and other light therapies target the wavelengths of the porphyrins in p. acnes to induce thermal damage that causes the bacterium's destruction. pulsed-dye laser (pdl ... | 2004 | 17134441 |
| alpha-hydroxyacids and carboxylic acids. | the carboxylic acids include alpha-hydroxyacids (ahas), polyhydroxy acids (phas), aldobionic acids (abas), retinoic acid, vitamin c and azelaic acid. they all have therapeutic actions. ahas, phas and abas are organic hydroxyacids, a group of natural and physiological substances which can modulate skin keratinization and increase biosynthesis of dermal components. because of these effects, ahas, phas and abas are therapeutically effective or beneficial for topical treatment of dry skin, rough ski ... | 2004 | 17147560 |
| topical retinoid and antibiotic combination therapy for acne management. | the agents most commonly used in combination for the management of acne include topical retinoids and antibiotics. topical retinoids normalize desquamation of the follicular epithelium, whereas antibiotics inhibit the growth of p. acnes and the production of free fatty acids. this therapeutic combination decreases comedogenesis, bacterial growth, and inflammation, thus targeting three of the four pathogenic factors associated with acne. efficacy and tolerance are maximized with combination thera ... | 2004 | 15098969 |
| purification and characterisation of lipoglycan macroamphiphiles from propionibacterium acnes. | lipidated macroamphiphiles such as the lipoteichoic acids and mycobacterial lipoarabinomannans are cell envelope components of gram-positive bacteria that have been extensively associated with the pathogenesis of disease. in order to study such associations, purification of these macroamphiphiles is essential for resolving their structures and diverse biological effects. we describe herein a method for purification of lipoglycan components from propionibacterium acnes. this method uses the exist ... | 2004 | 15103239 |
| topical antibacterial treatments for acne vulgaris : comparative review and guide to selection. | topical antibacterial agents are an essential part of the armamentarium for treating acne vulgaris. they are indicated for mild-to-moderate acne, and are a useful alternative for patients who cannot take systemic antibacterials. topical antibacterials such as clindamycin, erythromycin, and tetracycline are bacteriostatic for propionibacterium acnes, and have also been demonstrated to have anti-inflammatory activities through inhibition of lipase production by p. acnes, as well as inhibition of l ... | 2004 | 15109272 |
| characterization of thoeniicin 447, a bacteriocin isolated from propionibacterium thoenii strain 447. | fifteen strains of propionibacteria, isolated from dairy products, were screened for the production of bacteriocins. propionibacterium thoenii 447 produced an antimicrobial peptide, thoeniicin 447, which acted bactericidal against lactobacillus delbrueckii subsp. bulgaricus and bacteriostatic against propionibacterium acnes. thoeniicin 447 remained active after 15 min at 100 degrees c and after 30 min of incubation at ph 1-10. the peptide was inactivated when treated with pepsin, pronase, alpha- ... | 2004 | 15109792 |
| shunt nephritis with positive titers for anca specific for proteinase 3. | the authors report a case of shunt nephritis with antineutrophil cytoplasmic autoantibody (anca) and review 2 similar cases. a 55-year-old man was admitted to our hospital for continuous fever and foot edema in 2002. a ventriculoperitoneal shunt was implanted because of a brain abscess and subsequent hydrocephalus in 1987; it was changed to a ventriculoatrial (va) shunt in 1995. urinary analysis showed proteinuria (5.4 g/d) and microscopic hematuria. laboratory data showed renal dysfunction and ... | 2004 | 15112193 |
| late-onset central nervous system shunt infections with propionibacterium acnes: diagnosis and management. | 2004 | 15118785 | |
| propionibacterium acnes biotypes and susceptibility to minocycline and keigai-rengyo-to. | propionibacterium acnes is the predominant organism in acne lesions, but the sensitivity of different biotypes of p. acnes to therapeutic agents has seldom been reported. | 2004 | 15125499 |
| evidence for recruitment of plasmacytoid dendritic cell precursors to inflamed lymph nodes through high endothelial venules. | recruitment of dendritic cells (dcs) to lymph nodes (lns) is pivotal to the establishment of immune response. whereas dcs have been proven to undergo afferent lymphatic pathway to enter lns from peripheral tissues, a question remains if dcs also migrate into lns directly from the circulation. here we demonstrate that plasmacytoid dc (pdc) precursors can transmigrate across high endothelial venules (hevs) of inflamed lns in mice. bacterial infection induces a significant number of pdc and myeloid ... | 2004 | 15159375 |
| antimicrobial activities of eucalyptus leaf extracts and flavonoids from eucalyptus maculata. | we investigated the antimicrobial activities of eucalyptus leaf extracts to find effective antibacterial agents. | 2004 | 15189289 |
| evidence for diversity within propionibacterium acnes: a comparison of the t-cell stimulatory activity of isolates from inflammatory acne, endocarditis and the laboratory. | propionibacterium acnes is primarily associated with the pathogenesis of acne vulgaris but reports are increasing in number implicating p. acnes in other diseases such as abscess formation, meningitis and endocarditis. the pathogenicity of p. acnes is thought to be partly due to the interaction of the bacterium with the immune system. historically, investigations have focused on humoral and cell-mediated immune responses to p. acnes antigens without attention to the possibility that different an ... | 2004 | 15196160 |
| the role of pulsed light and heat energy (lhe) in acne clearance. | propionibacterium acnes synthesize and store a large amount of porphyrins. once the porphyrin is exposed to visible light it becomes chemically active and transfers to an excited state, resulting in the formation of singlet oxygen, which combines with cell membranes to destroy the p. acnes. this process is dependent on the rate of production of excited porphyrin molecules, which is influenced by the concentration of porphyrins, the concentration of photons, the temperature, and the wavelength of ... | 2004 | 15203999 |
| antibiotic resistance in the topical treatment of acne vulgaris. | topical antimicrobial agents are the first line of treatment in mild to moderate acne vulgaris. the primary pathogenic agent implicated in the development of inflammatory acne is propionibacterium acnes. p acnes also may play a secondary role in noninflammatory acne or comedogenesis. over the past 20 years, concern has grown about the gradual worldwide increase in the prevalence of antibiotic-resistant p acnes strains. factors associated with the development of resistant p acnes following treatm ... | 2004 | 15228128 |
| roles of cd14 in lps-induced liver injury and lethality in mice pretreated with propionibacterium acnes. | the mechanism of the liver damage and lethality in propionibacterium acnes (p. acnes)-lps system remains obscure. to examine the role of cd14 in the system, m14m mice, in which cd14 was expressed heterotopically under the control of the metallothionein promoter were used. the production of soluble cd14 (scd14) was increased by both p. acnes - priming and lps challenge (1 microg per mouse) in both nontransgenic and m14m mice, although the plasma level was much higher in m14m nontransgenic than mi ... | 2004 | 15234535 |
| propionibacterium acnes causing delayed subdural empyema - a case report and review of literature. | the authors report a patient who presented with a delayed subdural empyema caused by propionibacterium acnes following excision of a meningioma. this organism should be suspected in all patients with delayed empyema especially in the presence of implants and immunosuppression. the main features of this pathogen is discussed. surgical drainage and high-dose intravenous penicillin should be the recommended therapy. | 2004 | 15261253 |
| validation of bact/alert plastic culture bottles for use in testing of whole-blood-derived leukoreduced platelet-rich-plasma-derived platelets. | bacterial detection of platelet (plt)-rich-plasma (prp)-derived plts presents unique challenges for countries that do not allow pooling before storage. this study validated the bact/alert for use in testing pooled prp-derived plts with nine contaminating organisms. | 2004 | 15265121 |
| acne update: 2004. | acne vulgaris is a common skin disorder among children and young adults that carries enormous financial and psychosocial impact. contemporary therapies attempt to address factors underlying acne as a disorder of the pilosebaceous unit. these longstanding paradigms regarding pathogenesis and treatment continue to evolve in light of recent work on this ubiquitous disease. | 2004 | 15273498 |
| indigenous pulmonary propionibacterium acnes primes the host in the development of sarcoid-like pulmonary granulomatosis in mice. | although many cases of sarcoidosis are self-limiting with spontaneous remission, uncontrolled pulmonary granulomatosis with fibrosis produces intolerable long-term respiratory symptoms in a minority of patients. individuals with chronic pulmonary sarcoidosis require an alternative therapy to corticosteroidal treatment because of its insufficient effectiveness. although many researchers have considered infection as the triggering factor for this disease, the mechanisms by which the candidate caus ... | 2004 | 15277236 |
| the complete genome sequence of propionibacterium acnes, a commensal of human skin. | propionibacterium acnes is a major inhabitant of adult human skin, where it resides within sebaceous follicles, usually as a harmless commensal although it has been implicated in acne vulgaris formation. the entire genome sequence of this gram-positive bacterium encodes 2333 putative genes and revealed numerous gene products involved in degrading host molecules, including sialidases, neuraminidases, endoglycoceramidases, lipases, and pore-forming factors. surface-associated and other immunogenic ... | 2004 | 15286373 |
| in vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against propionibacterium sp. | honokiol and magnolol, two major phenolic constituents of magnolia sp., have been known to exhibit antibacterial activities. however, until now, their antibacterial activity against propionibacterium sp. has not been reported. to this end, the antibacterial activities of honokiol and magnolol were detected using the disk diffusion method and a two-fold serial dilution assay. honokiol and magnolol showed strong antibacterial activities against both propionibacterium acnes and propionibacterium gr ... | 2004 | 15288590 |
| benzoyl peroxide-based combination therapies for acne vulgaris: a comparative review. | benzoyl peroxide, with its broad-spectrum antimicrobial activity, is among the most widely used topical agents in the treatment of inflammatory acne vulgaris. benzoyl peroxide is marketed either alone or in combination with other topical antibiotics; namely, erythromycin and clindamycin. the combination products confer specific advantages over benzoyl peroxide alone, particularly in decreasing the in vivo follicular counts of propionibacterium acnes, the anaerobic bacterium implicated in the pat ... | 2004 | 15301572 |
| [microbiology of acute exacerbation chronic sinusitis in adults]. | the bacterial flora taken by sinus puncture from 115 patients with uni and bilateral acute exacerbation of chronic maxillary sinusitis was analyzed. germ-free culture was obtained in 49 cases (40%) and in 69 cases (60%) bacteria were isolated from all sinus aspirates. microbiological evaluation shows, that in majority of cases (90%) of acute exacerbation of chronic sinusitis there were pathogenic bacteria namely aerobic and anaerobic. the most frequent pathogens isolated from the aspirates were; ... | 2004 | 15307480 |
| propionibacterium acnes endocarditis on an annuloplasty ring in an adolescent boy. | propionibacterium acnes, a constituent of the human cutaneous flora, infected both the native mitral valve and a carpentier mitral annuloplasty ring in an adolescent patient. in the case of culture negative endocarditis, the incubation period of blood cultures should be prolonged to identify this pathogen. | 2004 | 15310725 |
| increased interleukin-10 associated with low il-6 concentration correlated with greater survival rates in mice infected by rabies virus vaccinated against it and immunomodulated with p. acnes. | macrophage activity, cytokines serum concentration, serum neutralizing antibodies and lethality by rabies were evaluated in swiss mice experimentally infected with street rabies virus and submitted or not to antirabies vaccination and immunomodulation with p. acnes. animals were killed at different times and serum was collected in order to evaluate cytokines concentration; peritonial and splenic macrophages were collected for macrophage activity evaluation. greater survival rates higher il-10 an ... | 2004 | 15325513 |
| beta-lactamase production and antimicrobial susceptibility of subgingival bacteria from refractory periodontitis. | this study assessed the extent of beta-lactamase-producing bacteria in subgingival plaque samples obtained from 25 patients with refractory marginal periodontitis in the usa. beta-lactamase-positive isolates were characterized using commercial diagnostic kits and partial sequencing of the 16s rrna gene. the susceptibilities to different antimicrobial agents were tested and, in addition, the isolates were screened for the presence of extended spectrum beta-lactamases (esbls). beta-lactamase-produ ... | 2004 | 15327642 |
| distal catheter obstruction from non-infectious cause in ventriculo-peritoneal shunted children. | in hydrocephalic children, ventriculo-peritoneal shunting is the preferred treatment with few complications. however, an obviously non-infectious peritoneal reaction to the cerebrospinal fluid (csf) may occasionally lead to shunt malfunction. in eight hydrocephalic children, shunt malfunction with distal catheter complication was found with abdominal pseudocyst formation in seven cases and accumulation of the csf in one. all children had a normal csf cell count and glucose concentration, and whi ... | 2004 | 15343464 |
| selective priming to toll-like receptor 4 (tlr4), not tlr2, ligands by p. acnes involves up-regulation of md-2 in mice. | lipopolysaccharide (lps) triggers cytokine production through toll-like receptor 4 (tlr4), which shares downstream signaling pathways with tlr2. we investigated the roles of tlr2 and tlr4 in propionibacterium acnes (p. acnes)-primed, lps-induced liver damage using selective tlr ligands. stock lps induced interleukin 8 in both tlr4- and tlr2-expressing human embryonic kidney (hek) 293 cells. purified lps (tlr4 ligand) activated hek/tlr4 cells, while peptidoglycan and lipoteichoic acid (tlr2 ligan ... | 2004 | 15349893 |
| antibody response to crude cell lysate of propionibacterium acnes and induction of pro-inflammatory cytokines in patients with acne and normal healthy subjects. | propionibacterium acnes (p. acnes) plays an important role in the disease pathogenesis of acne vulgaris, a disorder of pilosebaceous follicles, seen primarily in the adolescent age group. in the present study, the presence of antibodies against p. acnes (mtcc1951) were detected in acne patient (n=50) and disease free controls (n=25) using dot-elisa and western blot assay. the ability of p. acnes to induce pro-inflammatory cytokines by human peripheral blood mononuclear cells (pbmcs), obtained fr ... | 2004 | 15357305 |
| inducible histamine protects mice from p. acnes-primed and lps-induced hepatitis through h2-receptor stimulation. | inducible histamine and histamine h2-receptors have been suggested to be involved in innate immune response. | 2004 | 15362044 |
| topical aminolaevulinic acid-photodynamic therapy for the treatment of acne vulgaris: a study of clinical efficacy and mechanism of action. | acne affects 83-95% of 16-year-olds of both sexes, and many seek help from a clinician. emerging problems with conventional acne treatments, specifically antibiotic resistance of propionibacterium acnes and fears over the safety and tolerance of oral isotretinoin, create a demand for novel treatment modalities in acne. | 2004 | 15377348 |
| some like it hot. | 2004 | 15378808 | |
| the pathophysiology of acne vulgaris in children and adolescents, part 1. | microcomedones, the earliest lesions of acne, appear at adrenarche, which typically occurs at about 8 years of age when androgens of adrenal origin begin to stimulate follicular hyperkeratosis and sebaceous hyperplasia in pilosebaceous units on the face. comedones appear about 2 years later, when androgens of gonadal origin are produced and colonization of follicles by propionibacterium acnes increases. inflammatory lesions, such as pustules, papules, and nodules, are the result of the host's im ... | 2004 | 15379361 |
| a status report on the use of subantimicrobial-dose doxycycline: a review of the biologic and antimicrobial effects of the tetracyclines. | 2004 | 15379364 | |
| photochemical treatment of platelet concentrates with amotosalen and long-wavelength ultraviolet light inactivates a broad spectrum of pathogenic bacteria. | bacterial contamination of platelet (plt) concentrates can result in transfusion-transmitted sepsis. a photochemical treatment (pct) process with amotosalen hcl and long-wavelength ultraviolet light (uva), which cross-links nucleic acids, was developed to inactivate bacteria and other pathogens in plt concentrates. | 2004 | 15383024 |
| activity of nadifloxacin (opc-7251) and seven other antimicrobial agents against aerobic and anaerobic gram-positive bacteria isolated from bacterial skin infections. | the in vitro activity of nadifloxacin (opc-7251), a novel topical fluoroquinolone, was assessed and compared with those of ofloxacin, oxacillin, flucloxacillin, cefotiam, erythromycin, clindamycin, and gentamicin against 144 gram-positive bacteria: 28 staphylococcus aureus, 10 streptococcus spp., 68 coagulase-negative staphylococci (cns), 36 propionibacterium acnes, and 2 propionibacterium granulosum strains. all strains originated from bacterial-infected skin disease and were isolated from pati ... | 2004 | 15452398 |
| involvement of cd14 in lipopolysaccharide- induced liver injury in mice pretreated with propionibacterium acnes. | the aim of this study was to elucidate the role of cd14 in the propionibacterium acnes-lipopolysaccharide (lps) system. | 2004 | 15459483 |
| antibacterial activity of ent-kaurene diterpenoids from rabdosia rosthornii. | biological activities of ent-kaurene diterpenoids, rosthornins a-d, isolated from the ether extract of the dried leaves of rabdosia rosthornii (diels) hara (labiatae) were tested. they exhibited antibacterial activity specifically against gram-positive bacteria, among which propionibacterium acnes was noted to be the most susceptible. | 2004 | 15022175 |
| proinflammatory cytokine production by human keratinocytes stimulated with propionibacterium acnes and p. acnes groel. | keratinocytes form the first line of defence in the skin and alert the host to danger by the production of a number of cytokines and chemokines. however, the interaction of commensal microorganisms with keratinocytes has not been well studied. | 2004 | 15030323 |
| evaluation of the antibacterial efficacy of diesters of azelaic acid. | a number of diesters of the topical dermatosis treatment azelaic (nonanedioic) acid were prepared and tested for antibacterial effect. two esters, bis-[(hexanoyloxy)methyl] nonanedioate and especially bis-[(butanoyloxy)methyl] nonanedioate showed promising activity against acne related bacteria in vitro. no activity of azelaic acid was detected in mueller hinton ii agar at ph 7.3 when using the agar diffusion method, whereas both esters gave zones of growth inhibition. at ph 5.6, activity of aze ... | 2004 | 15066659 |
| [how i treat... belgian consensus document on the treatment of acne]. | this article describes the consensus on the treatment of acne, reached by a belgian working group. an effective treatment has to rely as much as possible on the pathophysiologic factors: the increased production of sebum, the abnormal desquamation (retention hyperkeratosis) of the epithelium of he sebaceous gland, the proliferation of propionibacterium acnes and inflammation. the therapeutic arsenal contains topical as well as systemic drugs. this consensus gives an overview of both modalities a ... | 2004 | 15646735 |
| newer therapies for cutaneous sarcoidosis: the role of thalidomide and other agents. | skin involvement occurs in a third of patients with sarcoidosis. the type of lesions can range from the transient erythema nodosum to the chronic facial lesion lupus pernio. for some patients with sarcoidosis, lesions on the face or elsewhere on the body may be the major or only indication for therapy. these lesions are often chronic and the use of corticosteroids may lead to more long-term complications. conventional alternatives to corticosteroids include antimalarial agents, methotrexate, and ... | 2004 | 15663335 |
| the use of a bacteria detection system to evaluate bacterial contamination in plt concentrates. | random-donor plts (rdps) are functional at 7 days. nevertheless, since the mid-1980s, concern for bacterial contamination has caused the storage period to be reduced to 5 days. the ability of a bacteria detection system (bds, pall) to determine bacterial contamination and permit extension of the plt shelf life to 7 days was assessed. | 2004 | 14996189 |
| evaluation of a new generation of plastic culture bottles with an automated microbial detection system for nine common contaminating organisms found in plt components. | a microbial detection system (bact/alert 3d, biomérieux [formerly organon teknika]) has previously been validated with a variety of bacterial contaminants in plts. the recovery of nine organisms seeded into plts with new plastic culture bottles was studied in comparison to the current glass bottles. the use of plastic instead of glass would be expected to reduce the risk of injury. | 2004 | 14996192 |
| in situ assessment of porphyrin photosensitizers in propionibacterium acnes. | porphyrins are known to be efficient photosensitizer molecules and the combined action of light and porphyrins in propionibacterium acnes have a lethal action on the cells. identification and quantification of in situ porphyrins in p. acnes have been done using an integrating sphere connected to an ordinary absorption spectrophotometer, and the amounts of porphyrins in the cells were quantified by measuring scattering free absorption spectra of the cell suspensions. the concentration of porphyri ... | 2004 | 15018060 |
| resolution of persistent periapical infection by endodontic surgery. | aim: to examine the surfaces of a root tip removed during surgical endodontic treatment for the presence of microorganisms. summary: the present clinical case illustrates an endodontic retreatment of a maxillary premolar tooth with a fistula and periapical reaction. the case was under treatment for 1 year, during which an intracanal medicament was replaced several times. as the lesion did not decrease and exudate was persistent through the fistula and root canal, root end resection with root end ... | 2004 | 14870760 |
| propionibacterium acnes and the pathogenesis of progressive macular hypomelanosis. | background: progressive macular hypomelanosis is a common hypopigmentation mainly on the central parts of the trunk, predominantly in young adults, especially women. it is often mistaken for pityriasis versicolor and pityriasis alba. it occurs in all races and has been described in many parts of the world. we discovered follicular red fluorescence restricted to lesional skin. we suspected a relation with a porphyrin-producing bacteria residing in sebum of the pilosebaceous duct, and we therefore ... | 2004 | 14967796 |
| pleurodesis for malignant pleural effusions. | approximately half of all patients with metastatic cancer develop a malignant pleural effusion which is likely to lead to a significant reduction in quality of life secondary to symptoms such as dyspnoea and cough. the aim of pleurodesis in these patients is to prevent re-accumulation of the effusion and thereby of symptoms, and avoid the need for repeated hospitalization for thoracocentesis. numerous clinical studies have been performed to try to determine the optimal pleurodesis strategy, and ... | 2004 | 14973997 |
| antimicrobial activity of mahonia aquifolium crude extract and its major isolated alkaloids. | the crude extract of mahonia aquifolium (pursh) nutt. stem bark and its two main protoberberine alkaloids, berberine and jatrorrhizine, were tested for their in vitro antimicrobial activity. twenty strains of coagulase-negative staphylococci and 20 strains of propionibacterium acnes isolated from skin lesions of patients with a severe form of acne, and 20 strains of candida sp. isolated from chronic vulvovaginal candidoses were tested for their susceptibility to crude extract and two isolated al ... | 2004 | 15476315 |
| topical antibacterial therapy for acne vulgaris. | topical antibiotics and benzoyl peroxide, are the two main topical antibacterial treatments indicated for mild-to-moderate acne vulgaris. topical antibiotics act both as antibacterial agents suppressing propionibacterium acnes in the sebaceous follicle and as anti-inflammatory agents. benzoyl peroxide is a powerful antimicrobial agent that rapidly destroys both bacterial organisms and yeasts. topical clindamycin and erythromycin have been proven to be effective against inflammatory acne vulgaris ... | 2004 | 15481998 |
| endophthalmitis after intravitreal injection of frozen preprepared tissue plasminogen activator (tpa) for pneumatic displacement of submacular hemorrhage. | 2004 | 15492643 | |
| the pathophysiology of acne vulgaris in children and adolescents, part 2: tailoring treatment. | various pathophysiologic factors are involved in the development of acne lesions, microcomedones, comedones, and inflammatory lesions. these factors include follicular hyperkeratosis, increased colonization of follicles by propionibacterium acnes, increased sebum production, and inflammatory mediators. optimal treatment of acne involves the use of agents that address these various underlying pathogenetic factors. | 2004 | 15499761 |
| retrospective case review of capsular contracture after two-stage breast reconstruction: is colonization of the tissue expander pocket associated with subsequent implant capsular contracture? | periprosthetic capsular contracture is a common problem associated with implant-based breast reconstruction. the purpose of this study was to determine if bacterial colonization of the tissue expander contributes to contracture of the permanent implant. medical records were reviewed for 86 patients (124 tissue expanders) between 1997 and 2001 in 1 institution. three specimens taken from the expander were cultured. the overall incidence of colonization was 42.7%; 49.4% (38.8-60.0) of immediate an ... | 2004 | 15502455 |
| abscess formation within cerebellar metastatic carcinoma--report of two cases and review of the literature. | the occurrence of an abscess in conjunction with a tumor in the brain is very rare. only presumptions exist about their origin and manner of dissemination. preoperative discrimination between a brain tumor with cystic degeneration and a brain abscess within a tumor may be difficult or even impossible. the purpose of this report is to demonstrate the difficulty of such discrimination using conventional ct diagnostics alone. | 2004 | 15506313 |
| late onset posttraumatic propionibacterium acnes endophthalmitis. | to report a case of late onset posttraumatic endophthalmitis secondary to propionibacterium acnes infection. | 2004 | 15506609 |
| [characteristics of the propionibacterium strains isolated from acne patients]. | propionibacterium acnes is a component of physiological flora of human skin. it colonizes the outlets of sebaceous glands and participates in the pathogenesis of inflammatory acne. acne vulgaris is a common skin disease. it is found in more or less exacerbated form in approximately 85% of adolescent population. the main purpose of the research was to confirm the hypothesis of propionibacterium bacteria participation in the aetiopathogenesis of acne vulgaris. the researches have proved the presen ... | 2004 | 15524399 |
| propionibacterium acnes endophthalmitis with bacterial sequestration in a molteno's implant after cataract extraction. | to report a case of propionibacterium acnes endophthalmitis following uncomplicated cataract extraction with bacterial sequestration in a preexisting molteno's drainage implant. | 2004 | 15531335 |
| 420 nm intense continuous light therapy for acne. | topical antibiotics, isotretinoin or systemic antibiotics are usually used for acne therapy. however, isotretinoin cannot be used during pregnancy because it can cause significant birth defects while systemic antibiotics can have adverse side effects such as gastrointestinal irritation, photosensitivity and tetracycline sensitivity. describe here is a high-intensity, narrow-band, blue light (clearlight) system, and its therapeutic clinical effect is investigated on acne using cutaneous measureme ... | 2004 | 15545101 |
| acne and sebaceous gland function. | the embryologic development of the human sebaceous gland is closely related to the differentiation of the hair follicle and the epidermis. the number of sebaceous glands remains approximately the same throughout life, whereas their size tends to increase with age. the development and function of the sebaceous gland in the fetal and neonatal periods appear to be regulated by maternal androgens and by endogenous steroid synthesis, as well as by other morphogens. the most apparent function of the g ... | 2004 | 15556719 |
| acne and propionibacterium acnes. | the involvement of microorganisms in the development of acne has a long and checkered history. just over 100 years ago, propionibacterium acnes (then known as bacillus acnes) was isolated from acne lesions, and it was suggested that p. acnes was involved in the pathology of the disease. the 1960s saw the use of antibiotics to treat acne, and the consequent clinical success combined with reductions in p. acnes gave new impetus to the debate. over the past two decades, the inevitable emergence of ... | 2004 | 15556721 |
| acne: inflammation. | the inflammatory stage of acne vulgaris is usually of greatest concern to the patient. a number of morphologically different inflammatory lesions may form that can be painful and unsightly. in 30% of patients, such lesions lead to scarring(1). inflammatory acne and acne scarring can have significant psychological effects on the patient, including depression, anxiety, and poor self-image(2). although inflammatory acne has been well characterized clinically, the mechanisms by which inflammatory le ... | 2004 | 15556722 |
| acne: topical treatment. | acne vulgaris is a common skin disease, affecting about 70-80% of adolescents and young adults. it is a multifactorial disease of the pilosebaceous unit.(1) the influence of androgens at the onset of adolescence leads to an enlargement of the sebaceous gland and a rise in sebum production. additional increased proliferation and altered differentiation of the follicular epithelium eventually blocks the pilosebaceous duct, leading to development of the microcomedo as the primary acne lesion. conco ... | 2004 | 15556726 |
| single species biofilm-forming ability of root canal isolates on gutta-percha points. | the participation of bacterial biofilms in the over-filled gutta-percha points associated with refractory periapical periodontitis has recently been reported. this study investigated the initial biofilm-forming ability of root canal isolates (enterococcus faecalis, streptococcus sanguis, strep. intermedius, strep. pyogenes, staphylococcus aureus, fusobacterium nucleatum, propionibacterium acnes, porphyromonas gingivalis and prevotella intermedia) on gutta-percha points in vitro. each bacterial s ... | 2004 | 15560836 |
| inactivation of gram-negative and gram-positive bacteria in red cell concentrates using inactine pen110 chemistry. | the risk of transfusion-transmitted bacterial infections as a result of the presence of bacteria in blood is one of the major concerns in transfusion medicine. the purpose of this study was to investigate whether bacteria inoculated into red blood cell concentrates can be inactivated by the inactine pen110 pathogen-reduction process. four bacterial species were chosen for the study: anaerobic gram-positive clostridium perfringens and propionibacterium acnes, known to be transfusion-transmitted; ... | 2004 | 15569065 |
| anaerobic, non-sporulating, gram-positive bacilli bacteraemia characterized by 16s rrna gene sequencing. | owing to the difficulties in identifying anaerobic, non-sporulating, gram-positive bacilli in clinical microbiology laboratories, the epidemiology and clinical spectrum of disease of many of these bacteria have been poorly understood. the application of 16s rrna gene sequencing in characterizing bacteraemia due to anaerobic, non-sporulating gram-positive bacilli during a 4-year period is described. the first case of olsenella uli bacteraemia, in a patient with acute cholangitis, is also reported ... | 2004 | 15585505 |
| in vitro activities of cefotaxime, vancomycin, quinupristin/dalfopristin, linezolid and other antibiotics alone and in combination against propionibacterium acnes isolates from central nervous system infections. | to evaluate the antibiotic susceptibilities of propionibacterium acnes isolates from central nervous system (cns) infections to agents used in current treatment regimens. | 2004 | 15590714 |
| successful recovery of infective endocarditis-induced rapidly progressive glomerulonephritis by steroid therapy combined with antibiotics: a case report. | the mortality rate among patients with infective endocarditis, especially associated with the presence of complications or coexisting conditions such as renal failure and the use of combined medical and surgical therapy remains still high. prolonged parenteral administration of a bactericidal antimicrobial agent or combination of agents is usually recommended, however, the optimal therapy for infective endocarditis associated with renal injury is not adequately defined. | 2004 | 15610562 |
| microbiology of chronic hyperplastic sinusitis. | patients with chronic hyperplastic sinusitis (chs) form a heterogeneous group with similar symptoms and similar treatment despite of possible different mechanisms behind the disease. in the present study we focused on the microbiological findings in chs and compared these results to the patient history in order to find out a possible explanation for the aetiology and chronicity of chs. | 2004 | 15626254 |
| [study on anti-bacterium activity of ginkgolic acids and their momomers]. | ginkgolic acids and their three monomers were separated from ginkgo sarcotestas. the anti-bacterium activity of ginkgolic acids were tested. the relation between the anti-bacterium activity and side chain of ginkgolic acid were studied. | 2004 | 15704587 |
| the new age of acne therapy: light, lasers, and radiofrequency. | background: current treatments for acne vulgaris include topical and oral medications that counteract microcomedone formation, sebum production, propionibacterium acnes, and inflammation. concerns about the short- and long-term consequences of these medications, along with technological advancements, have to significant progress in the management of acne. these developments include light, laser, and radio frequency, which may offer faster onset of action, equal or greater efficacy, and greater c ... | 2004 | 16020203 |
| endophthalmitis isolates and antibiotic sensitivities: a 6-year review of culture-proven cases. | to investigate the spectrum of organisms causing culture-proven endophthalmitis and their sensitivities to commonly used antimicrobial agents. | 2004 | 14700642 |
| role of core biopsy in diagnosing infection before revision hip arthroplasty. | a prerevision core biopsy from a failed hip joint was performed in 41 hips (38 patients) with a high index of suspicion for sepsis to determine its efficacy in diagnosing sepsis. seven hips were known septic failures, and core biopsy was undertaken to confirm resolution of sepsis. forty hips were revised, whereas 1 hip had excision of heterotopic bone. cultures and permanent histologic sections were obtained during subsequent surgeries, and findings were compared with the results of core biopsy. ... | 2004 | 14716655 |
| studies on the cytotoxic effects of propionibacterium acnes strains isolated from cornea. | eukaryotic tissue culture appears to be a suitable model for measuring the bacterial cytotoxic effect. propionibacterium acnes strains were isolated from corneal tissue removed by keratoplastic surgery from patients with corneal dystrophy or bullous keratopathy. the cytotoxic effect of the filtrates of 10 p. acnes strains were studied by means of measuring the decrease of the mitochondrial dehydrogenase activities of viable epithelial (hela) and fibroblastic (bhk-21) cell cultures. a time and co ... | 2004 | 14726235 |
| mobilization of dendritic cell precursors into the circulation by administration of mip-1alpha in mice. | dendritic cells (dcs) play a central role in immune responses and may be useful adjuvants for tumor vaccine therapy. we previously reported that f4/80(-)b220(-)cd11c(+) dc precursors expressing the cc chemokine receptors ccr1 and ccr5 are mobilized rapidly into the circulation in mice injected with propionibacterium acnes and are recruited into inflammatory tissue by macrophage inflammatory protein 1alpha (mip-1alpha), which binds to ccr1 and ccr5. here we investigate the mechanisms of dc precur ... | 2004 | 14759987 |
| cutting edge: dendritic cells copulsed with microbial and helminth antigens undergo modified maturation, segregate the antigens to distinct intracellular compartments, and concurrently induce microbe-specific th1 and helminth-specific th2 responses. | to examine the ability of dendritic cells (dc) to discriminate between helminth and microbial ag and induce appropriately polarized th responses, mouse dc were copulsed with the helminth ag, schistosome egg ag (sea), along with the bacterium proprionebacterium acnes, pa, and transferred into wild-type mice. strikingly, sea/pa-copulsed dc induced concurrent pa-specific th1 (but not th2) responses and sea-specific th2 (but not th1) responses. although dc exposed to both ag undergo many of the matu ... | 2004 | 14764665 |
| induction of a chemoattractive proinflammatory cytokine response after stimulation of keratinocytes with propionibacterium acnes and coproporphyrin iii. | the inflammation in acne vulgaris is widely thought to be induced by an immunological reaction, but the role of propionibacterium acnes is unclear. | 2005 | 16029328 |
| propionibacterium acnes. a cause of pneumatocele associated pneumonia. | propionibacterium acnes is a normal inhabitant of the skin and mucosal surfaces and is rarely identified as a cause of significant infection. reports of chest infections by this organism are limited. we report a case of pneumatocele-associated pneumonia caused by this organism and review the literature. | 2005 | 16047068 |
| propionibacterium acnes wound contamination at the time of spinal surgery. | bacteria of the normal skin microbiota such as propionibacterium acnes and coagulase-negative staphylococci often are dismissed as contaminants when detected in clinical samples. propionibacterium acnes is described as a cause of spinal infection and more recently has been linked to sciatica. to date no researchers formally have examined the incidence of bacterial wound contamination during spinal surgery. surgical specimens were removed from 79 patients having spinal surgery for analysis using ... | 2005 | 16056028 |
| introduction: welcome to the next generation of acne research. | 2005 | 16092792 | |
| insights in the pathogenic potential of propionibacterium acnes from its complete genome. | one of the long-lasting open questions in understanding acne is the role of the skin bacterium propionibacterium acnes. opinions within the scientific community diverge regarding the importance of this gram-positive bacterium not only in acne but also in other p. acnes-associated diseases. the recently decoded genome gives us some clues with respect to its pathogenic potential and its strategies to survive in the harsh environment of human skin. this review focuses on the major findings of the g ... | 2005 | 16092793 |
| implications for the role of diet in acne. | within the dermatology community, a general consensus has emerged that diet is unrelated to the etiology of acne. except for 2 poorly designed studies, now more than 30 years old, there are few objective data to support this notion. in contrast, a large body of evidence now exists showing how diet may directly or indirectly influence the following 5 proximate causes of acne: (1) increased proliferation of basal keratinocytes within the pilosebaceous duct, (2) incomplete separation of ductal corn ... | 2005 | 16092796 |
| hormonal therapy for acne using oral contraceptive pills. | the etiology of acne vulgaris is multifactorial and complex. the four key factors involved in the development of acne include follicular plugging, inflammation, the presence and activity of propionibacterium acnes, and sebum. androgen hormones stimulate the sebaceous gland and promote sebum excretion. therefore, therapies that have an overall antiandrogen effect, like combination oral contraceptive pills, may be useful in the management of acne vulgaris. numerous combination oral contraceptive p ... | 2005 | 16092798 |
| lasers and light therapy for acne vulgaris. | acne vulgaris remains an emotionally and debilitating dermatologic disease, and is conventionally treated with a variety of oral and topical therapies with a number of significant side effects. an evolving understanding of laser-tissue interactions involving propionibacterium acnes-produced porphyrins, and the development of infrared nonablative lasers to target sebaceous glands, has lead to the development of an escalating number of laser, light and radiofrequency devices for acne. used as mono ... | 2005 | 16092799 |
| granulysin-derived peptides demonstrate antimicrobial and anti-inflammatory effects against propionibacterium acnes. | propionibacterium acnes is a key therapeutic target in acne, yet this bacterium has become resistant to standard antibiotic agents. we investigated whether the human antimicrobial protein granulysin is a potential candidate for the treatment of acne. granulysin and synthetic granulysin-derived peptides possessing a helix-loop-helix motif killed p. acnes in vitro. modification of a helix-loop-helix peptide, 31-50, by substitution of a tryptophan for the valine at amino acid 44 (peptide 31-50v44w) ... | 2005 | 16098035 |
| current use of anti-infectives in dermatology. | dermatologic diseases encompass a broad category of pathologic situations. infection remains a significant aspect of the pathology faced in patient encounters, and it is natural to expect that anti-infectives play a major element in the armamentarium utilized by dermatologists. aside from the treatment of the classic bacterial and fungal infections, there are now new uses for antiviral agents to help suppress recurrent disease, such as herpes simplex. there is also the novel approach of using an ... | 2005 | 16107197 |
| evaluation of bact/alert plastic culture bottles for use in testing pooled whole blood-derived leukoreduced platelet-rich plasma platelets with a single contaminated unit. | in certain countries, whole blood-derived platelet (plt)-rich plasma plts can only be pooled within 4 hours of transfusion. one prerequisite for prestorage pooling is the ability to detect low levels of bacteria from a single unit (approx. 10 colony-forming units [cfus]/ml) once pooled (10/6 approx. 2 cfus/ml). this study evaluated the bact/alert (biomérieux) for detection of bacteria in 1 unit of a 6-unit pool. | 2005 | 16131385 |
| microbiology of acute exacerbation of chronic sinusitis. | we undertook to evaluate the microbiology of acute exacerbation of chronic sinusitis (aecs). | 2005 | 16134356 |
| infectious keratitis in the corneal graft: treatment with partial conjunctival flaps. | the infection of the corneal graft is one of the most serious complications following keratoplasty. in many instances, it can be treated successfully with intensive topical and subconjunctival antibiotics. however, when this therapy is ineffective, a surgical approach must be considered. the usefulness of partial conjunctival flaps that spare the visual axis for managing corneal graft infections is reported. | 2005 | 16156146 |
| the pathophysiology of acne. | acne is a multifactorial inflammatory disease affecting pilosebaceous follicles. the initial event in the development of an acne lesion is abnormal desquamation of the keratinocytes that line the sebaceous follicle, which creates a microplug or microcomedo. an increase in circulating androgens at the onset of puberty stimulates the production of sebum into the pilosebaceous unit. these events combine to create an environment within the pilosebaceous unit that is favorable for the colonization of ... | 2005 | 16164150 |
| in vivo evaluation of the effect of essential oil-containing oral strips on salivary bacteria using the checkerboard method. | the aim of this study was to evaluate the antimicrobial effect of essential oil-containing oral strips on different species of the oral microbiota. | 2005 | 16170974 |
| ctla-4ig suppresses liver injury by inhibiting acquired immune responses in a mouse model of fulminant hepatitis. | expression of costimulatory molecules is significantly upregulated in various organs in an animal model of severe hepatitis induced by injection of propionibacterium acnes (p. acnes) and lipopolysaccharide (lps). in the present study, we examined whether blockade of costimulatory signals by ctla-4ig can suppress the liver injury in this model. we injected an adenovirus encoding ctla-4ig (adctla-4ig) into mice 7 days before, on the same day, or 3 days after p. acnes priming. the virus was found t ... | 2005 | 16175605 |
| toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by propioni- bacterium acnes. | recognition of gram-positive bacteria by toll-like receptor 2 (tlr2) induces activation of proinflammatory pathways. in mice, sensitization with the gram-positive propionibacterium acnes followed by a challenge with the tlr4 ligand, lipopolysaccharide (lps), results in fulminant hepatic failure. here, we investigated the role of tlr2 in liver sensitization to lps-induced injury. stimulation of chinese hamster ovary cells and peritoneal macrophages with heat-killed p. acnes required expression of ... | 2005 | 16204620 |
| review of the innate immune response in acne vulgaris: activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. | acne vulgaris is a common disorder that affects 40-50 million people in the usa alone. the pathogenesis of acne is multifactorial, including hormonal, microbiological and immunological mechanisms. one of the factors that contributes to the pathogenesis of acne is propionibacterium acnes; yet, the molecular mechanism by which p. acnes induces inflammation is not known. recent studies have demonstrated that microbial agents trigger cytokine responses via toll-like receptors (tlrs). tlrs are patter ... | 2005 | 16205063 |
| [pathophysiology of acne]. | several pathogenic factors contribute to the development of acne, among them, seborrhea, follicular hyperkeratosis, propionibacteria, and inflammatory events. this article reviews current knowledge of these pathogenic factors. | 2005 | 16215770 |
| [propionibacterium acnes adenitis]. | propionibacterium acnes is a gram-positive pleomorphic rod-shaped anaerobic saprophyte of the skin, mouth and upper respiratory tract. although associated with acne vulgaris, it is otherwise reported as a human pathogen only rarely, in various infections, notably cutaneous and osteoarticular, and in endocarditis. we report here a case of bilateral p. acnes-abscessed adenitis of the inguinal folds. | 2005 | 16225253 |
| amplified-fragment length polymorphism analysis of propionibacterium isolates implicated in contamination of blood products. | propionibacterium acnes is implicated in most cases of bacterial contamination of platelet concentrates (pcs). to determine the source of contamination, amplified-fragment length polymorphism (aflp) analysis was applied. this dna fingerprinting technique was used to study the molecular relationship of 44 isolates derived from 22 pcs and 22 corresponding red blood cells concentrates (rbcs) from the same whole blood donations. the aflp results together with sequencing analysis of the 1,200 bp of t ... | 2005 | 16225662 |
| european surveillance study on the antibiotic susceptibility of propionibacterium acnes. | propionibacterium acnes strains are recovered from infections linked to surgical procedures, foreign bodies and septicaemia. this study investigated the antibiotic susceptibility patterns of p. acnes isolates from different systemic infections and determined the genomic diversity among resistant p. acnes isolates with low-frequency restriction analysis of chromosomal dna by pulsed-field gel electrophoresis (pfge). in total, 304 p. acnes isolates from 13 laboratories in 13 european countries were ... | 2005 | 15715718 |
| mixing glycolic acid with retinaldehyde: ralga, a technical achievement. | the use of retinaldehyde or glycolic acid was found to be effective in topical acne treatments. | 2005 | 15724101 |
| cutting edge: all-trans retinoic acid down-regulates tlr2 expression and function. | a major consequence of microbial infection is the tissue injury that results from the host inflammatory response. in acne, inflammation is due in part to the ability of propionibacterium acnes to activate tlr2. because all-trans retinoic acid (atra) decreases inflammation in acne, we investigated whether it regulates tlr2 expression and function. treatment of primary human monocytes with atra led to the down-regulation of tlr2 as well as its coreceptor cd14, but not tlr1 or tlr4. the ability of ... | 2005 | 15728448 |