Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| current diagnosis and treatment of helicobacter pylori. | 1994 | 8191764 | |
| helicobacter pylori, the pathologist's point of view. | 1994 | 8191856 | |
| in vitro studies on stability and development of metronidazole resistance in helicobacter pylori. | seventy isolates of helicobacter pylori from antral biopsy samples were tested for their susceptibilities to metronidazole by agar dilution. seven (10%) of these clinical isolates appeared to be resistant to metronidazole. sixty-three strains were susceptible. in 42 (67%) of the 63 susceptible isolates, resistant isolates were obtained by serial passage on plates containing subinhibitory concentrations of metronidazole. in 10 of these 42 strains, the acquired resistance appeared to be unstable. ... | 1994 | 8192465 |
| possible role of helicobacter pylori infection in early gastric cancer development. | gastric cancer is the most frequently diagnosed malignancy in japan. the possible relationship between helicobacter pylori infection and gastric cancer in japan was evaluated. | 1994 | 8194007 |
| natural gastric infection with helicobacter pylori in monkeys: a model for spiral bacteria infection in humans. | there is no generally accepted model for helicobacter pylori infection in humans. the aim of this study was to examine the natural history and effect of treatment in rhesus monkeys and sequentially define the immune response to h. pylori in relation to treatment. | 1994 | 8194685 |
| bisulfite or sulfite inhibits growth of helicobacter pylori. | bisulfite or sulfite was found to be inhibitory to helicobacter pylori growth. a modified version of brucella broth (bb), bisulfite-less bb (blbb), supported rapid, robust, and consistent growth of h. pylori. we suggest that blbb simply be called "pylori broth" for distinction from brucella broth. | 1994 | 8195395 |
| [immunohistochemical study of helicobacter pylori and mononuclear cells in the gastric mucosa of patients with gastritis or peptic ulcer]. | the distribution and localization of helicobacter pylori (hp) and mononuclear cells (mnc) in the gastric mucosa were investigated immunohistochemically in 120 patients with gastritis or peptic ulcer. hp was detected in the gastric mucosa of 58% of 40 gastritis patients, 82% of 56 gastric ulcer (gu) patients, and 88% of 24 duodenal ulcer (du) patients. in the hp-positive mucosa, cells positive for igg or iga were increased significantly when compared to the hp-negative mucosa. neutrophils and eos ... | 1994 | 8196206 |
| [omeprazole modified antibiotic therapy of helicobacter pylori infection: can clarithromycin be replaced by roxithromycin?]. | thirty-five consecutive patients (median age: 50 years, 17 men and 18 women) suffering from helicobacter pylori associated peptic ulcer disease (duodenal ulcer: n = 15, gastric ulcer: n = 13) or severe functional dyspepsia (n = 7) were enrolled in a two-center clinical trial and treated with omeprazole 20 mg bid preprandially and roxithromycin 300 mg bid postprandially over two weeks. after cessation of the study medication, ulcer patients received a full dose h2-blocker treatment up to the fina ... | 1994 | 8196468 |
| enhanced mucosal interleukin-6 and -8 in helicobacter pylori-positive dyspeptic patients. | to determine the concentrations of interleukin-1 beta, interleukin-6, and interleukin-8 in tissue homogenates of mucosal biopsy specimens from helicobacter pylori-positive and -negative patients. | 1994 | 8198099 |
| decrease in ornithine decarboxylase activity after eradication of helicobacter pylori. | our aim was to determine whether gastric mucosal odc activity is altered after successful eradication of hp. recent reports have suggested that helicobacter pylori (hp) infection of the stomach is associated with the development of gastric cancer. gastrointestinal cancers usually do not arise de novo; a series of mucosal changes leading to neoplastic transformation and degrees of dysplasia are believed to precede the development of cancer. these conditions are associated with increased cellular ... | 1994 | 8198100 |
| the relationship between helicobacter pylori-associated gastritis or ulcer disease and gastric emptying. | forty-five patients with helicobacter pylori (hp)-associated gastritis or ulcer disease were included in this study. radionuclide-labelled solid meals were used to calculate gastric emptying times (gets) and carbon-14 urea breath tests (14c ubts) were used to measure the hp colonies quantitatively. the patients were assessed according to the following two criteria: (a) the hp colony number (i.e. high or low) and (b) the recorded duration of the get (i.e. long or short). there was no statisticall ... | 1994 | 8200387 |
| healing of protein losing hypertrophic gastropathy by eradication of helicobacter pylori--is helicobacter pylori a pathogenic factor in ménétrier's disease? | hypertrophic gastropathy--that is, ménétrier's disease--was found, in a retrospective analysis, to be associated with helicobacter pylori in more than 90% of patients. it is proposed that hypertrophic gastropathy represents a special form of h pylori gastritis in these patients. a case is described of a 28 year old woman with ménétrier's disease associated with proved protein loss from the stomach. treatment with cimetidine for more than three years had little benefit when colonisation by h pylo ... | 1994 | 8200570 |
| helicobacter pylori infection. | 1994 | 8200579 | |
| are tryptase and cathepsin d related to helicobacter pylori infection and mucosal gastrin in peptic ulcer? | the pathogenesis of peptic ulcer is a complex phenomenon and several factors are thought to be involved in this process. among others, helicobacter pylori infection, hypergastrinaemia and some proteases seem to play an essential role in inducing peptic ulceration. we investigated whether tryptase (a serine endoprotease released by mast cells) and cathepsin d (a lysosomal hydrolase which seems able to derange the extracellular matrix) play a part in peptic ulcer disease and whether they are linke ... | 1994 | 8202635 |
| helicobacter pylori colonization in children with gastritis and peptic ulcer. i. the colonization rate and effects of colonization on mucin content and mucosal inflammation in the antrum. | the incidence of helicobacter pylori infection and effects of h. pylori colonization on mucin content and mucosal inflammation of the antral mucosa were studied quantitatively in 55 japanese children with suspected gastritis and peptic ulcers (aged 6-16 years, mean 12.3 years). h. pylori was detected, using warthin-starry stain, in nine of the 22 cases (41%) with antral histological gastritis, but in none of the 33 histologically normal cases. five out of seven duodenal ulcer cases showed histol ... | 1994 | 8203261 |
| helicobacter pylori colonization in children with gastritis and peptic ulcer. ii. ultrastructural change of the gastric mucosa. | to evaluate the role of helicobacter pylori in the pathogenesis of gastritis and peptic ulcer in children, ultrastructural changes of the gastric mucosa with h. pylori colonization were studied in two pediatric patients with duodenal ulcers. the study demonstrated that h. pylori: (i) colonized the mucous layer covering normal gastric epithelium; (ii) lay atop short, irregular microvilli and at the intercellular junctions of damaged cells; and (iii) adhered firmly by specific junction zone (firm ... | 1994 | 8203262 |
| [the psychological characteristics of dyspepsia. a controlled study with gastroscopic follow-up]. | it's known that some psychologic factors could be implicated in dyspepsia. therefore, the psychologic aspects of 38 dyspeptic patients (17 males, 21 females, aged 18-65 years), who underwent digestive endoscopy, were evaluated by means of rorschach and mmpi test. patients with previous peptic ulcer history, with chronic ethanol or nsaid intake, operated on digestive tract and patients with behavioural problems were excluded. the results of psychological tests enhanced two main groups: anxiety pa ... | 1994 | 8204702 |
| [azithromycin-omeprazole. treatment for the eradication of helicobacter pylori]. | to evaluate the benefit of 4-week regimen including azithromycin+omeprazole (vs omeprazole alone) for eradication of helicobacter pylori. | 1994 | 8204705 |
| effects of cations on helicobacter pylori urease activity, release, and stability. | the urease of helicobacter pylori is an important antigen and appears critical for colonization and virulence. several studies have indicated a superficial localization for the h. pylori urease, and the purpose of this study was to determine the effects of cations on the release and stability of urease activity from h. pylori cells. incubation of partially purified h. pylori urease in water containing 1, 5, or 10 mm ca2+, mg2+, k+, na+, edta, or egta [ethylene glycol-bis(beta-aminoethyl ether)-n ... | 1994 | 8262643 |
| high prevalence of neutralizing activity to helicobacter pylori cytotoxin in serum of gastric-carcinoma patients. | helicobacter pylori infection is causally related to chronic type-b gastritis, and may also be associated with an increased risk of gastric carcinoma. vacuolating cytotoxin, which is an 87-kda protein secreted by h. pylori, induces eukaryotic cell vacuolation in vitro. to determine whether there is an association between h. pylori vacuolating cytotoxin and gastric carcinoma, we investigated several characteristics of h. pylori infection, i.e., isolation of h. pylori from gastric biopsies, antibo ... | 1994 | 8262677 |
| gastric lymphoma in an 11-year-old boy: a case report. | a child with prolonged abdominal symptoms was shown to have a concomitant gastric non-hodgkin lymphoma and gastritis caused by helicobacter pylori infection. after a course of antibiotics and 6 months of chemotherapy, the patient is disease free. the relationship of the microbial infection and tumor development is discussed. the case supports a hypothesis that local h. pylori infection may be a predisposing factor for gastric lymphoma. | 1994 | 8232084 |
| helicobacter pylori eradication, duodenal ulcer healing, and gastric secretory state. | 1994 | 8175003 | |
| helicobacter pylori eradication with bismuth subnitrate, oxytetracycline and metronidazole in patients with peptic ulcer disease. | a total of 152 patients with recurrent peptic ulcer disease were treated with bismuth subnitrate, oxytetracycline and metronidazole. the 51 patients in group 1 were included following a study of the effect of cognitive psychotherapy on the recurrence rate after curative treatment for duodenal ulcer (du). group 2 comprised 101 consecutive patients referred to us with recurrent peptic ulcer. their helicobacter pylori (hp) status was assessed before, and 4 weeks after, discontinuation of treatment, ... | 1994 | 8175114 |
| helicobacter pylori: incidence and comparison of three diagnostic methods in 196 saudi patients with dyspepsia. | one hundred and ninety-six symptomatic saudi patients with dyspepsia underwent gastroscopy, and multiple biopsies were taken from the antrum of the stomach for identification of helicobacter pylori. three methods were studied for diagnosis of helicobacter pylori, including urease test, culture and histopathology. the commonest gastroscopic findings were gastritis in 82 patients (41.84%) and duodenal ulcer in 40 patients (20.41%). among the 196 patients, helicobacter pylori was identified by hist ... | 1994 | 8175115 |
| idiotype identity in a malt-type lymphoma and b cells in helicobacter pylori associated chronic gastritis. | to investigate the mechanisms triggering malt-lymphoma development, we examined the occurrence of normal b cells in lymphoid tissue and chronic gastritis with the same idiotype as an iga-positive malt lymphoma. | 1994 | 8176897 |
| helicobacter pylori and nucleolar organizer regions in the gastric antral mucosa. | the association of helicobacter pylori with an increased risk of gastric adenocarcinoma has been documented, but its mechanisms have not been elucidated. this study explored these mechanisms by addressing the relationship between h pylori and the silver-staining nucleolar organizer regions (agnors) in the gastric antrum. the number of agnors per nucleus has been correlated with proliferative rate and ploidy. the results of gastric biopsies performed before and after treatment for h pylori showed ... | 1994 | 8178774 |
| omeprazole-induced increase in the absorption of bismuth from tripotassium dicitrato bismuthate. | omeprazole is an effective drug for treating active peptic ulcer, whereas tripotassium dicitrato bismuthate can prevent ulcer relapse if helicobacter pylori is eradicated. because both drugs will be given concomitantly, drug interactions have to be considered, especially since absorption of bismuth may be dependent on intragastric ph, which will be elevated by omeprazole. | 1994 | 8181192 |
| lack of protection against gastric helicobacter infection following immunisation with jack bean urease: the rejection of a novel hypothesis. | the common mucosal immune system was stimulated by oral immunisation with jack bean urease and the adjuvant cholera toxin. a high level of local antibody and serum antibody was induced in mice following hyperimmunisation with this combination. no cross-reacting antibody was found against either helicobacter pylori or helicobacter felis. no protection was observed against oral challenge of immunised mice with living h. felis thus disproving the interesting hypothesis of pallen and clayton that pl ... | 1994 | 8181696 |
| giardiasis of the stomach. | a patient with giardiasis in an inflamed gastric antral biopsy specimen is reported. helicobacter pylori were not identified and no other cause of the gastritis was apparent. this condition may be more common than has been previously supposed and may be linked to bile reflux or hypochlorhydria. | 1994 | 8183764 |
| elimination of recurrent hyperplastic polyps by eradication of helicobacter pylori. | 1994 | 8185131 | |
| familial helicobacter pylori infection. societal factors, human genetics, and bacterial genetics. | 1994 | 8185136 | |
| helicobacter pylori infection: genetic and environmental influences. a study of twins. | to investigate the importance of genetic effects for acquiring helicobacter pylori infection. | 1994 | 8185146 |
| [helicobacter pylori, one step further]. | 1994 | 8186000 | |
| a comparison of 16s ribosomal dna sequences from five isolates of helicobacter pylori. | other workers have found that clinical isolates of helicobacter pylori exhibit very extensive dna sequence polymorphisms when they are examined by ribotyping or some other genomic sequence characterization technique. in fact, it is rare to find similar clones, much less identical ones, among isolates. we found that the levels of divergence between the 16s ribosomal dna sequences of individual organisms and the consensus sequence of the five isolates which we examined ranged from 0.2 to 0.5%. in ... | 1994 | 8186097 |
| short report: clarithromycin, an alternative to metronidazole in the triple therapy of helicobacter pylori infection. | triple therapy for helicobacter pylori using metronidazole is less effective in patients with a metronidazole resistant strain. moreover, metronidazole is responsible for many side-effects. this open study examined the efficacy and side-effects of a triple treatment regimen substituting clarithromycin for metronidazole. | 1994 | 8186339 |
| zollinger-ellison syndrome and antral g-cell hyperfunction in patients with resistant duodenal ulcer disease. | we measured basal and pentagastrin-stimulated acid secretion, as well as basal and meal-stimulated plasma gastrin concentration to determine, in 67 patients affected by resistant duodenal ulcer, whether their condition could be related to gastric acid secretion and/or gastrin-related syndromes. we then compared them to 46 duodenal ulcer control patients. the outpatients were investigated consecutively. the resistant duodenal ulcer patients differed from the controls only in their higher complica ... | 1994 | 8186351 |
| [the therapy of helicobacter pylori infection]. | 1994 | 8187614 | |
| molecular structures that influence the immunomodulatory properties of the lipid a and inner core region oligosaccharides of bacterial lipopolysaccharides. | the relationship between chain length as well as the position of fatty acyl groups to the ability of lipid a to abolish the expression of suppressor t-cell (ts) activity was examined. fatty acyl chain lengths of c12 to c14, as in the lipid a of escherichia coli and salmonella minnesota, appear to be optimal for this bioactivity, since lipid a preparations with fatty acyl groups of relatively short chain length (c10 to c12 for pseudomonas aeruginosa and chromobacterium violaceum) or predominantly ... | 1994 | 8188347 |
| helicobacter pylori isolated from the domestic cat: public health implications. | helicobacter pylori has been directly linked with active chronic gastritis, peptic ulceration, and gastric adenocarcinoma in humans. although a substantial portion of the human population is colonized with h. pylori, the patterns of transmission of the organism remain in doubt, and reservoir hosts have not been identified. this study documents the isolation of h. pylori from domestic cats obtained from a commercial vendor. the isolation of h. pylori from these cats was confirmed by morphologic a ... | 1994 | 8188360 |
| mutation of the cytotoxin-associated caga gene does not affect the vacuolating cytotoxin activity of helicobacter pylori. | helicobacter pylori now is recognized as an etiological agent in chronic superficial gastritis and peptic ulcer disease. although only about 60% of h. pylori isolates produce an immunodominant 128-kda antigen (caga; cytotoxin-associated gene product), virtually all h. pylori-infected patients with duodenal ulceration develop a serologic response to the 128-kda protein, which suggests an association of this gene with ulceration. the cloned caga gene from h. pylori 84-183 was disrupted by insertio ... | 1994 | 8188385 |
| helicobacter pylori-associated peptic ulcer in heterotopic gastric mucosa within ileal duplication. | a 12-year-old boy, operated on for remitting abdominal pain and hematochezia, had an ileal duplication, with helicobacter "gastritis" under a chronic peptic ulcer in the ectopic fundic gastric mucosa. we suggest the helicobacter infection might have played a role in the pathogenesis of the inflammation and the peptic ulceration in this rare location. | 1994 | 8189008 |
| peptic ulcer disease mortality. comparison of native japanese, japanese americans, and caucasian americans. | peptic ulcer disease mortality patterns of california japanese are compared with those of their home and host countries for even years from 1960 to 1988, as well as 1989. data presented are consistent with the hypothesis that helicobacter pylori is a necessary but not sufficient causal factor in peptide ulcer disease, and that other co-factors including cigarette smoking and salt intake may be important. deaths due to peptic ulcer numbered 106 among california japanese, 12,793 for california cau ... | 1994 | 8189011 |
| helicobacter pylori infection and peptic ulcer disease in cameroon, west africa. | 1994 | 8189016 | |
| a gastroscopic study of the predictive value of risk factors for non-steroidal anti-inflammatory drug-associated ulcer disease in rheumatoid arthritis patients. | peptic ulcer disease (pud) in ra patients is associated with nsaid use. this study aimed to validate the predictive value of presumed risk factors for nsaid-associated pud in a prospective gastroscopic study in ra patients. eighty-one nsaid using ra patients were prospectively divided into four presumed risk groups according to helicobacter pylori status and history of pud. as additional risk factors the following were analysed: upper gastrointestinal gi complaints; disability; daily dose of nsa ... | 1994 | 8173849 |
| interrelationships between helicobacter pylori infection, nonsteroidal antiinflammatory drugs and gastroduodenal disease. a prospective study in healthy volunteers. | helicobacter pylori and nonsteroidal antiinflammatory drugs independently cause gastroduodenal mucosal injury but the relationship between them remains unclear. we have performed a double-blind, parallel-group, placebo-controlled prospective study in 77 healthy volunteers aged 19-35 years who were randomly allocated to indomethacin (n = 15), one of three oxicams (piroxicam, chlortenoxicam, or chf 1194; n = 36), or placebo (n = 26). esophagogastroduodenoscopy was performed before and after four w ... | 1994 | 8174421 |
| dyspepsia in healthy blood donors. pattern of symptoms and association with helicobacter pylori. | whether helicobacter pylori is causally linked to dyspepsia remains controversial. the aims of this study were to assess in healthy blood donors the prevalence of dyspepsia and dyspepsia subgroups, determine if h. pylori is associated with different categories of dyspeptic symptoms, and evaluate the association between dyspepsia and nicotine, alcohol, and analgesic use. consecutive blood donors (n = 180) who had no clinical evidence of organic disease were included. abdominal symptoms were measu ... | 1994 | 8174422 |
| a critique of therapeutic trials in helicobacter pylori-positive functional dyspepsia. | approximately 50% of patients with functional dyspepsia have helicobacter pylori infection; it remains controversial whether this infection causes chronic symptoms, but rigorously conducted therapeutic trials should establish whether h. pylori plays a role in functional dyspepsia. the aim here was to determine whether the trials published over the past 10 years were methodologically adequate to establish a role for this infection in functional dyspepsia. | 1994 | 8174880 |
| plasma gastrin concentrations are normal in patients with colorectal neoplasia and unaltered following tumor resection. | previous studies have found that colorectal cancer patients have hypergastrinemia, but most have been inadequately controlled. preoperative fasting and meal-stimulated gastrin levels were measured in patients with colorectal tumors (n = 42) and in carefully matched controls (n = 34). helicobacter pylori status was assessed because it causes significant hypergastrinemia. | 1994 | 8174887 |
| medium- or high-dose omeprazole plus amoxicillin eradicates helicobacter pylori in gastric ulcer disease. | to compare the efficacy of two omeprazole/amoxicillin regimens concerning helicobacter pylori eradication, ulcer healing, pain relief, and safety in patients with gastric ulcer disease. | 1994 | 8172146 |
| seasonal variation in the frequency of helicobacter pylori infection: a possible cause of the seasonal occurrence of peptic ulcer disease. | the seasonal variation of duodenal ulcer disease and its complications have been repeatedly demonstrated in israel by several independent studies. the aim of this study was to determine possible seasonal variations in the occurrence of h. pylori infection among dyspeptic patients in israel. | 1994 | 8172147 |
| evaluation of 14c-urinary excretion and its comparison with 14co2 in breath after 14c-urea administration in helicobacter pylori infection. | 1) to estimate levels of 14c-urinary excretion in helicobacter pylori-infected and noninfected patients after 14c-urea ingestion, 2) to compare 14c-urinary excretion and 14co2 breath results with biopsy findings, and 3) to find out correlation between 14c-urinary excretion with 14co2 breath results, if any. | 1994 | 8172148 |
| prolonged bedtime treatment with h2-receptor antagonists (ranitidine and famotidine) does not affect blood alcohol levels after ethanol ingestion in male patients with duodenal ulcer. | to verify whether a prolonged (therapeutic) treatment with ranitidine or famotidine may affect blood alcohol concentrations (bac) in patients with duodenal ulcer (du). | 1994 | 8172150 |
| epidemiology of non-hodgkin's lymphoma: recent findings regarding an emerging epidemic. | between 1973 and 1989, the incidence of non-hodgkin's lymphoma (nhl) increased by nearly 60% in the united states, one of the largest increases of any cancer. in 1993, approximately 43,000 new cases of nhl will be diagnosed and over 20,000 deaths due to nhl will occur. the annual incidence rate of nhl per 100,000 persons in the us has risen from 5.9 in 1950 to 13.7 in 1989. this increase has occurred in both males and females, blacks and whites, and in all age groups except the very young. the l ... | 1994 | 8172811 |
| assessment of helicobacter pylori infection. | 1994 | 8158584 | |
| [the characteristics of duodenogastric reflux in peptic ulcer and chronic gastritis]. | patients with gastroduodenal ulcer, chronic gastritis (cg) and healthy controls (124, 57 and 24 subjects, respectively) were examined for intensity and duration of duodenogastric reflux (dgr). these indices were assessed by concentrations of gastric juice bilirubin. it is found that dgr occurred in 29% of the examinees free of gastroduodenal diseases, does not correlate with morphological cg-induced changes and helicobacter pylori contamination degree. the reflux in cg seems to be secondary in p ... | 1994 | 8160143 |
| [the pharmacodynamic and ulcer-healing action of modern anti-ulcer agents]. | in a study of 159 duodenal ulcer patients the authors studied the effect of h2-blockers, antibacterial and sucralfate monotherapy on the frequency of the ulcer healing, helicobacter pylori (hp) infection and acid-proteolytic aggression in the body and antropyloric portion of the stomach. all the drugs were found to exhibit similar antiulcer activity. inhibition of the acid-proteolytic aggression in the gastric body was registered only under the action of h2-blockers. antibacterial preparations i ... | 1994 | 8160144 |
| relation between igg and iga antibody titres against helicobacter pylori in serum and severity of gastritis in asymptomatic subjects. | to investigate whether the absorbance index of igg and iga antibodies against helicobacter pylori is related to a semiquantitative assessment of the density of h pylori colonisation in gastric biopsy specimens and to the severity of gastritis. | 1994 | 8163693 |
| seroconversion for helicobacter pylori. | 1994 | 8163707 | |
| gene structure of the helicobacter pylori cytotoxin and evidence of its key role in gastric disease. | the gram negative, microaerophilic bacterium helicobacter pylori colonizes the human gastric mucosa and establishes a chronic infection that is tightly associated with atrophic gastritis, peptic ulcer, and gastric carcinoma. cloning of the h. pylori cytotoxin gene shows that the protein is synthesized as a 140-kd precursor that is processed to a 94-kd fully active toxin. oral administration to mice of the purified 94-kd protein caused ulceration and gastric lesions that bear some similarities to ... | 1994 | 8163943 |
| intravenous helicobacter pylori induces low levels of tnf-alpha and il-1 alpha in a murine model. | a murine model for testing cytokine production stimulated by helicobacter pylori is described. h. pylori induced significantly lower levels of tnf-alpha and il-1 alpha compared to escherichia coli or pseudomonas aeruginosa when injected intravenously. the mean tnf-alpha concentration in serum during 6 h after stimulation with h. pylori was 0.2 ng/ml, whereas e. coli induced 4.7 ng/ml and p. aeruginosa 6.0 ng/ml. this was not explained by rapid elimination of h. pylori as bacteria were present fo ... | 1994 | 8167000 |
| [role of helicobacter pylori in digestive disease in aids]. | the frequent combination of chronic antral gastritis with the presence of helicobacter pylori has been known for ten years. on the basis of studies carried out so far, helicobacter gastritis is very infrequent in patients suffering from aids with digestive pathology. our study of 317 patients with aids confirms the low incidence of this disorder which leads to the conclusion that the treatments intended to combat hiv are apt to modify the physico-chemical conditions of the stomach thus impeding ... | 1994 | 8168346 |
| [clinical aspect and diagnosis of helicobacter pylori infection]. | 1994 | 8168425 | |
| [antimicrobial sensitivity and treatment of helicobacter pylori infections]. | helicobacter pylori (hp) is considered the etiological agent of chronic active gastritis and suspicion is strong that it plays an important role in duodenal ulcer. recently, several clinical studies reported that eradication of hp markedly reduces the frequency of ulcer relapse. triple-drug treatment, including a bismuth salt and 2 antibiotics (usually metronidazole with either amoxycillin or tetracycline) is considered the treatment of choice. it has been shown that the most important factor fo ... | 1994 | 8168742 |
| pathological significance and molecular characterization of the vacuolating toxin gene of helicobacter pylori. | some strains of helicobacter pylori are known to produce an extracellular cytotoxin that causes vacuolization in various mammalian cells. in this study, we found that concentrated culture supernatants from four helicobacter strains isolated from patients infected with the bacterium, but having normal gastric mucosa, lacked cytotoxic activity. we also show that a higher percentage of strains isolated from patients with polymorphonuclear leukocyte infiltration of gastric mucosa are toxin positive ... | 1994 | 8168917 |
| identification and molecular characterization of a major ring-forming surface protein from the gastric pathogen helicobacter mustelae. | the spiral microaerophilic bacterium helicobacter mustelae is linked to gastritis and gastric ulcers in ferrets. electron microscopy of h. mustelae showed the presence of a laterally extensive array of 8.5-nm-diameter rings on the cell surface, which was shown to be composed of a 150kda protein. this protein was purified, and the sequence of 10 amino-terminal residues was determined. polyclonal antibody against the purified 150 kda protein labelled the ring structures on the homologous strain by ... | 1994 | 8170397 |
| seroprevalence of helicobacter pylori infections in a cohort of us army recruits. | to study the prevalence and risk factors of helicobacter pylori infection in healthy young adults, sera were collected from a nationwide sample of 404 females and 534 males (mean age, 20.2; range, 17-26 years) at induction into the us army at fort jackson, south carolina, during the fall of 1990. an enzyme-linked immunosorbent assay (pylori stat, biowhittaker, inc., walkersville, md) was used to detect h. pylori-specific immunoglobulin g antibodies. demographic data were obtained from a personne ... | 1994 | 8154475 |
| helicobacter pylori infection and gastric lymphoma. | helicobacter pylori infection is a risk factor for gastric adenocarcinoma. we examined whether this infection is also a risk factor for primary gastric non-hodgkin's lymphoma. | 1994 | 8145781 |
| gastric lymphoma and helicobacter pylori. | 1994 | 8145788 | |
| [current therapy of helicobacter pylori infection]. | 1994 | 8145628 | |
| relation between infection with helicobacter pylori and living conditions in childhood: evidence for person to person transmission in early life. | to relate the prevalence of infection with helicobacter pylori in adults to their living conditions in childhood to identify risk factors for infection. | 1994 | 8142828 |
| evolution of concepts regarding helicobacter pylori: from a cause of gastritis to a public health problem. | 1994 | 8147345 | |
| helicobacter pylori reinfection rate, in patients with cured duodenal ulcer. | to determine the reinfection rate of the gastric mucosa in patients previously cured of duodenal ulcers, following the eradication of helicobacter pylori. only those remaining h. pylori-negative beyond 12 months of follow-up were studied, to minimize the potential inclusion of patients with h. pylori recrudescence. | 1994 | 8147355 |
| vitamin c concentration in gastric juice before and after anti-helicobacter pylori treatment. | to investigate the change of vitamin c concentration (ascorbic and dehydroascorbic acid) in gastric juice after anti-helicobacter pylori treatment, and to relate any observed change to gastric ph, inflammatory compromise of the gastric mucosa, plasma vitamin c concentration, and smoking habits. | 1994 | 8147356 |
| helicobacter pylori. | helicobacter pylori is the cause of chronic active gastritis. it is integral to the pathogenesis of peptic ulcer disease and is epidemiologically linked to gastric cancer and lymphoma. helicobacter pylori can be detected through a variety of invasive (urease testing, culture, or histologic diagnosis of endoscopic biopsies) and noninvasive (urease breath tests, serologic tests) diagnostic tests. it is now appropriate to detect and eradicate h pylori in patients with a peptic ulcer as the natural ... | 1994 | 8147675 |
| acute gastritis associated with spiral organisms from cats. | numerous studies implicated helicobacter pylori as one causative agent producing gastritis and dyspepsia. recent reports focus on another bacterium, gastrospirillum hominis, as a possible pathogen producing gastritis. we report a 30-year-old researcher who became acutely ill with epigastric pain indicative of esophagitis or peptic ulcer disease. gastritis and a gastric ulcer were observed endoscopically. histological examination of the gastric mucosa revealed an acute gastritis and large spiral- ... | 1994 | 8149839 |
| prevalence of peptic ulcer in helicobacter pylori positive blood donors. | this study aimed to determine the importance of raised antibodies to helicobacter pylori in an asymptomatic population. a total of 128 asymptomatic blood donors who were seropositive for h pylori and consented to endoscopy were investigated. these subjects were from a population of 1010 blood donors screened for antibodies to h pylori. a questionnaire was completed to determine if any subjects had complained of symptoms, and they subsequently had endoscopy. altogether 121 of 128 were positive fo ... | 1994 | 8150337 |
| high prevalence of helicobacter pylori infection in cohabiting children. epidemiology of a cluster, with special emphasis on molecular typing. | intrafamilial cases of infection with the same strain of helicobacter pylori (h pylori) have been reported but these clusters were too small to distinguish between person to person spread or coinfection from a common environmental source. to gain more information on the mode of transmission of h pylori, an epidemiological survey with bacterial strain differentiation by restriction endonuclease analysis of chromosomal dna was carried out in an institution of 117 children with encephalopathy (aged ... | 1994 | 8150338 |
| effect of helicobacter pylori and its eradication on gastric juice ascorbic acid. | the presence of ascorbic acid in gastric juice may protect against gastric carcinoma and peptic ulceration. this study examined the effect of helicobacter pylori (h pylori) on the secretion of ascorbic acid into gastric juice by measuring fasting plasma and gastric juice ascorbic acid concentrations in patients with and without the infection and also before and after its eradication. gastric juice ascorbic acid concentrations in 19 h pylori positive patients were significantly lower (median 2.8, ... | 1994 | 8150339 |
| eradication of helicobacter pylori with clarithromycin and omeprazole. | clarithromycin, a new and well tolerated, acid stable macrolide antibiotic, has a similar antimicrobial spectrum to erythromycin but a better in vitro mic90 (0.03 microgram/l-1) against helicobacter pylori (h pylori). this study aimed at determining the eradication rate using clarithromycin 500 mg thrice daily and omeprazole 40 mg daily for two weeks. patients were given an endoscopy and h pylori status assessed by antral culture (microaerobic conditions, for up to 10 days), antral and corpus hi ... | 1994 | 8150340 |
| a 2-year study of helicobacter pylori in children. | from september 1990 to october 1992, helicobacter pylori was searched for in 426 children, 2 days to 16 years old, requiring upper fibroscopy for various symptoms. h. pylori was detected in 77 children (18.1%). recurrent abdominal pain was present in 63.3% of the patients with h. pylori versus 48.6% of a control group of 74 age-matched children negative for h. pylori, weight loss was present in 6.5% of the patients versus 0% of the control subjects, and a family history of peptic ulcer was prese ... | 1994 | 8150958 |
| ordered cosmid library and high-resolution physical-genetic map of helicobacter pylori strain nctc11638. | helicobacter pylori is a gram-negative bacterium that infects the human gastric mucosa, causes gastritis and contributes to the development of peptic ulcers and gastric cancer. to facilitate molecular genetic analysis of this pathogen, we constructed a approximately 20-fold redundant cosmid library and physical/genetic map of strain nctc11638. genomic dna fragments were cloned into the cosmid vector lorist6, and clones were ordered by hybridization with several types of probes: (i) ends of clone ... | 1994 | 8152375 |
| [functional dyspepsia. old wine in new bottles?]. | functional dyspepsia covers various symptoms associated by the physician with the upper gastrointestinal tract without an identifiable organic cause. the existence of dyspepsia subgroups according to different symptom complexes, e.g. so-called "ulcer-like dyspepsia", has not been proved. gastro-esophageal reflux disease is a distinguishable independent entity. little is known about the pathogenesis of this common syndrome. disturbances of gastric motility, especially postprandial antral hypomoti ... | 1994 | 8153599 |
| [acute ulcer disease: diagnosis, therapy, complications, indications for surgery]. | the development of fiberoptic endoscopy, the creation of drugs with well understood mechanisms of action, and the definition of the role of helicobacter pylori have resulted in a considerably better understanding of ulcer pathogenesis. this has led to rational concepts of ulcer therapy, which are discussed in detail in this review. moreover, the role of non-steroidal antiinflammatory drugs in peptic ulcer disease, and the use of drugs and endoscopic measures in treatment of ulcer complications, ... | 1994 | 8153601 |
| [helicobacter and peptic ulcer: history, diagnosis and therapy--when, in whom and how?]. | the pathogenesis of peptic ulcer disease is complex. it is associated with a spiral organism, helicobacter pylori, which induces chronic gastritis. the evidence for a causal association between h. pylori and peptic ulcer disease stems primarily from the observation that eradication therapy with bismuth and various antibiotics may produce normalization of gastritis and possible cure of ulcer disease. the prevalence of h. pylori infection and potential implications for therapy are discussed. who s ... | 1994 | 8153602 |
| divergence of genetic sequences for the vacuolating cytotoxin among helicobacter pylori strains. | approximately 50% of helicobacter pylori isolates produce a cytotoxin in vitro that induces vacuolation of eukaryotic cells. screening a lambda zapii library of h. pylori 60190 chromosomal fragments permitted the identification of a 3864-base pair (bp) open reading frame (vaca) that encoded the vacuolating cytotoxin, and a > or = 567-bp upstream gene that was homologous to escherichia coli cysteinyl-trna synthetase. the sequence data suggest that a 33-amino-acid leader sequence and a c-terminal ... | 1994 | 8144644 |
| [target for anti-ulcer agents--ph, h. pylori or no?]. | although until recently the reduction of gastric acid secretion was the primary aim in the treatment of peptic ulcer disease, it is now recognised that the presence of helicobacter pylori and not only acid is required to produce duodenal ulcer. accordingly, the part played by gastric acid has been relegated to the contributor to the effects of h pylori infection. recent research into the pathogenesis and treatment of peptic ulcer disease suggests the locus of receptors for acid stimulants, such ... | 1994 | 8139901 |
| peptic ulcer disease in children. | although much of the understanding of the pathogenesis of ulcer disease is derived from data studying adults, there are certain manifestations and presentations that differentiate ulcers in children from those seen in adults. therapy is aimed at reducing acid or improving mucosal defense. the recent recognition of the association of helicobacter pylori with acid peptic disease has added to our understanding of the disease process and opened new avenues of therapy. | 1994 | 8137017 |
| [use of the polymerase chain reaction to identify helicobacter pylori in clinical material]. | a new system for the detection of helicobacter pylori dna, based on the method of directed amplification, has been developed. primers for specific detection of h. pylori were selected from a nucleotide sequence of 16 s-p rna. the sequences of the primers had a few nucleotide substitutions as compared with the sequences of closely related microorganisms. an essential condition for the attainment of reaction specificity was the rise of annealing step temperature to 66 degrees c. sensitivity of the ... | 1994 | 8133843 |
| helicobacter pylori and gastrointestinal symptoms. | 1994 | 8135555 | |
| evaluation of a new immunodiagnostic assay for helicobacter pylori antibody detection: correlation with histopathological and microbiological results. | infection with helicobacter pylori has been associated with the pathogenesis of chronic active gastritis and gastric and duodenal ulcer disease. detection of immunoglobulin g antibodies to h. pylori offers a simple alternative to direct detection of the organism in biopsied tissue by culture or histopathological methods. a rapid flow-through membrane-based enzyme immunoassay for the detection of human immunoglobulin g antibodies to h. pylori has been developed and evaluated. clinical evaluations ... | 1994 | 8126203 |
| immunological and molecular characterization of helicobacter felis urease. | urease activity has recently been shown to be an important virulence determinant for helicobacter pylori, allowing it to survive the low ph of the stomach during colonization. experimental murine infection with helicobacter felis is now being used as a model for h. pylori infection to study the effects of vaccines, antibiotics, and urease inhibitors on colonization. however, little information comparing the ureases of h. felis and h. pylori is available. urease was partially purified from the ce ... | 1994 | 8112850 |
| "hemoptysis" as an expression of helicobacter pylori infection. | 1994 | 8126612 | |
| [rapid identification of bacteria by pcr and hybridization]. | the amplification of bacteria dna by pcr followed by rapid identification with hybridization are described. in the case of mycobacteria, a 206 bases in dnaj gene was amplified by nested pcr with conserved primers. the amplified dnas were then hybridized with species-specific oligoprobes. theses oligoprobes are capable of identifying the amplified dna as m. tuberculosis, m. avium, m. intracellulare, m. kansasii or others. in the case of mrsa, clinical samples were examined to amplify meca, fema a ... | 1994 | 8126883 |
| immunobiological activities of helicobacter pylori porins. | studies were carried out on some biological activities of helicobacter pylori porins in vitro. we extracted and purified a porin with an apparent molecular mass of 30 kda. human polymorphonuclear leukocytes preincubated with h. pylori porins showed a decrease of chemotaxis, of adherence to nylon wool, and of chemiluminescence. used as chemotaxins in place of zymosan-activated serum or as chemotaxinogens in place of zymosan, the porins induced polymorphonuclear leukocyte migration. human monocyte ... | 1994 | 8132346 |
| interleukin-8 expression in helicobacter pylori infected, normal, and neoplastic gastroduodenal mucosa. | to investigate the expression of interleukin-8 (il-8) in helicobacter pylori infected normal and neoplastic gastroduodenal mucosa, and in established gastric cancer cell lines. | 1994 | 8132812 |
| morphological transformation of helicobacter pylori during prolonged incubation: association with decreased acid resistance. | the survival of clinical isolates of h pylori at two cultural ages (two and four days) at ph 2, in the presence of different buffers, with and without urea, was investigated. it was found that the morphological changes which occur with longer incubation of h pylori have an inverse correlation with its resistance to an acidic environment. the finding that the addition of urea almost reversed this phenomenon and prolonged survival of the cultures emphasises the role of urea in the survival of h py ... | 1994 | 8132834 |
| cytotoxic activity of helicobacter pylori enhanced by acetohydroxamic acid. | 1994 | 8132843 | |
| alternative method for transporting and storing gastric biopsy cultures of helicobacter pylori. | 1994 | 8132844 | |
| gastric metaplasia and helicobacter pylori infection in intestinal tuberculosis. | gastric metaplasia occurs in intestinal epithelium of patients with helicobacter pylori infection as well as intestinal tuberculosis, but the relationship between the three is not clear. | 1994 | 8119751 |
| usefulness of specific igm in the diagnosis of helicobacter pylori infection. | 1994 | 8121752 |