Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [experimental study in japanese monkeys with helicobacter pylori infection]. | japanese monkeys were studied for one month from 6 months (short-term) after inoculation of helicobacter pylori, and two years (long-term). in the short-term study, macroscopic and histological gastritis were observed for 5 infected monkeys. the gastritis score, the ammonia concentration in the gastric secretion and the level of serum antibody (igg) were higher for the infected group than for the control. in the long term study, h. pylori was always recovered for 2 years in the infected group, a ... | 1993 | 8283620 |
| [experimental animal models in mongolian gerbils and mice]. | helicobacter pylori is an emerging candidate agent for the genesis of chronic gastritis and peptic ulcer. there have been many challenges to establish an experimental infection with h. pylori in animals. in recent, several studies reported for animal infection with this organism. one of them was the study using urinary system. the study indicated the ability of h. pylori to induce inflammation without significant low ph condition. experimental infection in mongolian gerbils showed that h. pylori ... | 1993 | 8283621 |
| [adhesion of helicobacter pylori--role of glycolipid adhesion receptors]. | in the gastric mucosa, the composition of acidic glycolipids has unique feature of enrichment of sulfatides over gangliosides. immunohistochemical staining using a monoclonal antibody demonstrated that the sulfated glycolipids specifically localized on surface epithelial cells. moreover, cultured gastric mucosal cells actively synthesized sulfated glycolipids. we have also shown that it may be recognized as an adhesion receptor by helicobacter pylori (hp). since other investigators have proposed ... | 1993 | 8283622 |
| [helicobacter pylori and urease activity--comparative study between urease positive and negative mutant strains]. | the ammonia concentration in the gastric juice from h. pylori positive cases was significantly higher than that from negative cases, and there was positive correlation between number of h. pylori, gastritis score and ammonia concentration in gastric juice. it is suggested that ammonia in gastric juice which is produced by powerful urease activity of h. pylori is one of the pathogenic factors in gastritis. we succeeded in producing a urease-negative mutant strain of h. pylori. this strain did not ... | 1993 | 8283623 |
| [role of ammonia-monochloramine system in helicobacter pylori--induced gastric mucosal injury]. | monochloramine is a reactive oxidant which is yielded by the reaction of neutrophil-derived hypochlorous acid and ammonia. luminol-dependent chemiluminescence assay reveals that h. pylori directly elicits a respiratory burst of neutrophils. this activation is also observed by adding the bacterial supernatant of cultured or sonicated h. pylori, suggesting that h. pylori-derived soluble factor may be responsible for the release of chlorinated oxidants. in vitro cytotoxicity assay indicates that cu ... | 1993 | 8283624 |
| [leukotriene levels of helicobacter pylori-infected gastric mucosa]. | helicobacter pylori appears to cause chronic active gastritis, which is characterized by infiltration by neutrophils. leukotrienes (lts), which are both chemotactic and cytotoxic, are produced mainly by neutrophils. we studied lt levels, h. pylori infection and neutrophils infiltration in gastric mucosa of patients with non-ulcer dyspepsia. lt levels of mucosa infected with h. pylori were higher than that in non-infected mucosa. there was a correlation between lt levels and neutrophils infiltrat ... | 1993 | 8283625 |
| [mucinase activity of helicobacter pylori: application of simplified mucinase test]. | we conducted the simplified mucinase tests about helicobacters (helicobacter pylori, helicobacter felis and helicobacter mustelae) and campylobacter jejuni, positive controls were pseudomonas maltophilia and pseudomonas cepacia. h. pylori, h. felis and c. jejuni showed low resolution activities for hog gastric mucin, however h. mustelae had no detectable the activities. this enzymatic activity varies considerably by cultural condition of h. pylori, therefore it is difficult to compare the activi ... | 1993 | 8283626 |
| [isolation identification and quantitative culture of helicobacter pylori from gastric mucosa]. | the biopsy specimens were homogenized and diluted ten-fold serially in hank's solution. each dilution samples were streaked on skirrow's selective medium. the plates were incubated at 37 degrees c 5 to 7 days under micro-aerobic condition and counting the viable cell of h. pylori. the positive rate of specimens with h. pylori in active gastric ulcer tissue (62.0%) was higher than that in scarred tissue (51.9%). number of h. pylori viable cells in active ulcer tissue was significantly larger than ... | 1993 | 8283627 |
| [detection of helicobacter pylori by polymerase chain reaction]. | the application of pcr method to the detection of h. pylori is reviewed. in most of the assays reported to date, primer pairs based on the sequences of urease and 16s rrna genes have been chosen. clinical samples tested have ranged widely from gastric biopsy specimens to gastric aspirates, feces, dental plaques, saliva, etc. as few as one organism can be detected by the most sensitive assay. the reports suggest that pcr assay is suited for laboratory diagnosis of the organism as well as epidemio ... | 1993 | 8283628 |
| [endoscopic diagnosis of helicobacter pylori distribution in human gastric mucosa by phenol red dye spraying method]. | helicobacter pylori (h. pylori) is known to show an uneven and patchy distribution on human gastric mucosa, close association with chronic gastritis and peptic ulcer diseases. the aim of this study was to clarify the distribution of this organism under direct vision by phenol red dye spraying endoscopy. in order to maintain gastric ph around ph 4.0 to 5.0, premedication was necessary either by intravenous injection of h2-blocker, 30 min before the test, or by oral administration of omeprazole 20 ... | 1993 | 8283629 |
| [staining for helicobacter pylori on gastric mucosa with dye from red cabbage during endoscopy]. | helicobacter pylori has a high urease activity and produces ammonia from urea, resulting in elevation of mucosal ph. based on this characteristics of h. pylori, we have developed a method for staining h. pylori under endoscopy using dye from red cabbage (san-red rc, san-ei chemical ind., osaka), a ph indicator, safe for clinical use. after administration of a proton-pump inhibitor and an h2-receptor antagonist, the dye solution, mixed with 2% urea, was sprayed over the mucosa by endoscope. chang ... | 1993 | 8283630 |
| [urease test]. | in order to elucidate bacterial infection, as a rule, isolated and cultured bacteria of a specimen are identified by their morphologies or biochemical characteristics. however, the culture of helicobacter pylori (h. pylori) is difficult and takes, much time. therefore, favorable test results are currently obtained by combining the culture method, histopathologic method, urease test and sero-immunologic test. the merits of the urease test are that judgement is available immediately after endoscop ... | 1993 | 8283631 |
| [elisa tests for detection of helicobacter pylori antibodies]. | the efficacy of commercial elisa tests for detection of helicobacter pylori antibodies was investigated. some investigators reported that six commercial elisa tests had sensitivities of 81-96%, and had specificities of 29-96%. it is possible that some of false-negative results by elisa may occur for patients who are in the acute phase of infection. when elisa tests gave false-positive results, it should be taken into account that there might be some false negative diagnoses for the gastric h. py ... | 1993 | 8283633 |
| [prevalence and distribution of helicobacter pylori in the stomach of patients by upper gastrointestinal endoscopy]. | the prevalence of h. pylori colonization in the antrum and body was examined in patients with gastritis, duodenal ulcer (du) and gastric ulcer (gu). the total prevalence was 63.5%, 90.0% and 85.5%, respectively. in patients with gastritis and du, the frequency was similar at both sites, while in gu patients h. pylori positivity was increased markedly in the body compared with the antrum. furthermore, in patients with antral and angular ulcers, biopsy studies from 8 different sites showed that th ... | 1993 | 8283634 |
| [helicobacter pylori and gastroduodenal ulcers]. | we studied the prevalence of helicobacter pylori (h.p.) infection in gastroduodenal diseases. h.p. was positive in 67.6% of gastric ulcer patients and 82.2% of duodenal ulcer patients. h.p. was detected with high frequency throughout the course of ulcer healing. short-term antimicrobial therapy, including cefixim, ofloxacin and bismuth subnitrate, was effective in 50% of h.p. positive patients. however, h.p. was detected again in a considerable number of patients one year after the treatment. hi ... | 1993 | 8283635 |
| [role of helicobacter pylori infection in gastric metaplasia in the duodenum in the production of duodenal ulcer]. | helicobacter pylori (h. pylori) is frequently detected in not only the antrum but also the gastric juice and the duodenum with gastric metaplasia, which is believed to be a response of duodenal mucosa to injury by hyperacidity, in most of duodenal ulcer patients. conversely, the normal duodenum is not infected with h. pylori in non-duodenal ulcer patients, even if h. pylori is present in the antrum and/or the gastric juice. all patients with h. pylori in the duodenum has the h. pylori infection ... | 1993 | 8283636 |
| [the role for helicobacter pylori infection in intractable and recurrent ulcer]. | patients with intractable peptic ulcer or recurrent peptic ulcer have high rate of helicobacter pylori infection. to study the effect of h. pylori on the recurrence of peptic ulcer, we treated the patients, who had h. pylori infection, with antibiotics (amoxicillin, clarithromycin, fosfomycin). after one year, none of peptic ulcer patient in whom h. pylori was eradicated had a recurrence. among patients who remained positive for h. pylori, the ulcer relapse rate was 61% (11 of 18). in patients w ... | 1993 | 8283637 |
| [relationship between helicobacter pylori colonization in the gastric mucosa and the severity of atrophic gastritis]. | we studied the relationship between helicobacter pylori infection and atrophic gastritis. eighty non-ulcer patients underwent endoscopy with biopsy. detection and quantitative assessment of h. pylori was made based on smear, culture and tissue section (gram stain). the extent of atrophic gastritis was assessed endoscopically according to the classification of kimura and takemoto. severity of glandular atrophy and intestinal metaplasia was assessed histologically. h. pylori infection was accompan ... | 1993 | 8283638 |
| [helicobacter pylori and the development of atrophic gastritis]. | a close relationship between h. pylori infection and atrophic gastritis has been reported, and atrophic gastritis has been thought of as one of the precursors of gastric carcinoma. it was reported that there was a significant positive correlation between the reduction of serum pepsinogen (pg) i/ii ratio and the progression of atrophic gastritis. the ratio of pg i/ii was significantly decreased in h. pylori positive patients when compared to h. pylori negative patients with chronic gastritis. the ... | 1993 | 8283639 |
| [helicobacter pylori infection in gastric cancer]. | the relationship between helicobacter pylori (h. pylori) infection and gastric cancer becomes the topics in the world, since some reports thereon in 1991. the purpose of this study was to know the prevalence of h. pylori infection in many patients with gastric cancer. we examined the h. pylori igg antibody in 507 patients with gastric cancer resected surgically in our hospital from 1989 to 1991, retrospectively. for the test of h. pylori igg antibody, hm-cap eia kit (italy, enteric products co.) ... | 1993 | 8283640 |
| [helicobacter pylori and gastric cancer in view of relation to atrophy of background gastric mucosa]. | to make clinical assessment regarding the role of helicobacter pylori (h. pylori) in the occurrence of gastric cancer, we examined serological and microbiological positive rate of h. pylori and histological and endoscopic findings of atrophic gastritis of background mucosa in 149 gastric cancer patients, 136 gastric ulcer patients, 82 chronic gastritis cases and 46 normal control. serological h. pylori positive rate examined using gap-igg in 43 gastric cancer patients was 95%, which was signific ... | 1993 | 8283641 |
| [clinico-pathological study of helicobacter pylori in early gastric cancer]. | the role of helicobacter pylori (hp) infection in the pathogenesis of various gastric diseases is an important but unresolved issue. to investigate the association between hp and the histological findings of the stomach in patients of early gastric cancer, the prevalence of hp in gastric mucosa and the mucosal alterations were examined histo-pathologically in the surgically resected stomach of 30 cases with early gastric cancer. serum igg antibodies for hp were determined in these cases. all 30 ... | 1993 | 8283642 |
| [activity of lansoprazole (new proton pump inhibitor) against helicobacter pylori and its therapeutic efficacy]. | lansoprazole, one of ppis, is a strong antacid and it cures stomach and duodenal ulcers at early stages as well as having antibiotic action towards hp. the in vitro mic of the product is between 3.13 and 12.5 micrograms/ml and it was 12.5 micrograms/ml, which was the same as mic of colloidal bismuth citrate, in our study. sterilizing effect of lansoprazole is reported to be the direct attack on hp bacteria from electron microscopic findings. our study revealed that lansoprazole would preserve th ... | 1993 | 8283644 |
| [effective regimen for eradication of helicobacter pylori]. | there is now substantial evidence that helicobacter pylori (h. pylori) is both a frequent cause of chronic gastritis and an important factor in the recurrence of duodenal ulcer. however, to achieve the eradication of h. pylori is very difficult and although a number of treatment regimens suppress this organism, the stomach usually becomes recolonized shortly after the cessation of treatment. many reports have shown that polytherapy is more effective than monotherapy. and so, the best results hav ... | 1993 | 8283645 |
| [eradication therapy of helicobacter pylori in gastroduodenal ulcer and its long-term course]. | we investigated the efficacy of antimicrobial drugs, amoxicillin and clarithromycin that have the in vitro activity against h. pylori, and observed a long term course of ulcer after eradication. the eradication rate of combination therapy with ppi and amoxicillin showed best result (13/18: 72%). in eradicated cases, index of pas positive substance and gastritis score in antral mucosa that is histological examination was improved, and ammonia concentration in gastric secretions decreased. the rec ... | 1993 | 8283646 |
| [relationship of helicobacter pylori to chronological transition of endoscopic atrophic pattern]. | the prevalence of helicobacter pylori (hp) were studied in 117 subjects with no gross findings whose stomach age was equal to its chronological age. hp was detected by culture. the prevalence of hp significantly was higher in thirties and forties than other ages, and in c3 and o1 groups than other groups. most of forties and fifties belonged to c3 or o1 groups. histologically, hp infection was significantly frequent in the gastric mucosa with advancing inflammation. these findings suggest that h ... | 1993 | 8283808 |
| ultrastructural localization of urease of helicobacter pylori. | helicobacter pylori urease was characterized by means of an enzyme histochemical electron microscopic technique. ultrastructural analysis revealed no urease activity in one strain; in seven h. pylori strains (43.75%), urease activity was associated with the cell membrane. eight strains (50.0%) showed reaction product located within the cytoplasm. urease activity showed no correlation with localization of activity. our results demonstrate that h. pylori urease is not uniform in all h. pylori stra ... | 1993 | 8283959 |
| chronic gastritis and helicobacter pylori in digestive form of chagas' disease. | patients with the digestive form of chagas' disease frequently present chronic gastritis. as the microorganism helicobacter pylori is now accepted as the most common cause of human chronic gastritis, the present work was undertaken to verify a possible relationship between the presence of this bacterium and inflammatory changes of antral mucosa in chagasic patients. seventeen chagasics, with megaesophagus and or megacolon were studied. fragments from two different regions of antral mucosa were o ... | 1993 | 8284595 |
| efficacy and side effects of a triple drug regimen for the eradication of helicobacter pylori. | one hundred consecutive patients with helicobacter pylori infection, as proven by culture, were treated with 120 mg colloidal bismuth subcitrate (cbs) four times daily, 250 mg tetracycline four times daily, and 250 mg metronidazole four times daily during 15 days. the patients were amply instructed in how to take the medicine and strongly urged to complete the prescribed course. in 66 of the 100 patients pretreatment metronidazole susceptibility was determined. endoscopy was performed 3 months a ... | 1993 | 8284626 |
| treatment of helicobacter pylori reduces the rate of rebleeding in peptic ulcer disease. | we evaluated whether therapy designed to eradicate helicobacter pylori infection resulted in a reduction in rebleeding in patients with peptic ulcer disease. patients presenting because of major upper gastrointestinal hemorrhage from peptic ulcer and whose ulcers healed in a study in which they were randomized to receive ranitidine alone or triple therapy plus ranitidine were followed up regularly with endoscopy. no maintenance anti-ulcer therapy was given after ulcer healing. | 1993 | 8284627 |
| parietal cell antibodies among peruvians with gastric pathologic changes. gastrointestinal physiology working group. | parietal cell antibodies were present in 12% of 272 peruvians presenting for endoscopy. gender, age, socioeconomic status, ethnic background (peruvian versus japanese), and altitude at which the patient lived were not associated with the presence of parietal cell antibodies. no significant relationship could be shown between the presence of parietal cell antibodies and either helicobacter pylori infection or gastric lesions, including chronic atrophic gastritis. loss of proper gastric glands was ... | 1993 | 8284633 |
| long-term omeprazole therapy does not affect helicobacter pylori status in most patients. | fifty-one patients were treated with 20-60 mg omeprazole for reflux oesophagitis resistant to h2-blocker therapy during a mean of 49 months of follow-up. with use of a standardized enzyme-linked immunosorbent assay technique specific igg and igg helicobacter pylori antibodies were determined in serum obtained at the start of therapy and at the most recent visit. at the start of therapy 26 patients (51%) had evidence of h. pylori infection, as demonstrated by increased igg and iga antibody levels ... | 1993 | 8284634 |
| does antral distension inhibit gastric acid secretion or stimulate bicarbonate secretion in 'healthy' subjects? | the effects of a 150-ml antral balloon distension on pentagastrin-stimulated gastric acid secretion and bicarbonate secretion were studied in nine healthy subjects and eight duodenal ulcer (du) patients. the gastric secretions were simultaneously measured, using a luminal perfusion and ph/pco2 measurements. two of the healthy subjects and six of the du patients were positive for helicobacter pylori. when h. pylori-positive and -negative subjects were compared, basal gastric acid and bicarbonate ... | 1993 | 8284638 |
| [nodular antritis and helicobacter pylori infection in children]. | we have studied 115 patients infected with helicobacter pylori (hp). endoscopic nodular antritis and histologic lymphonodular hyperplasia was noted. the frequency of nodular antritis was compared between the 115 hp patients and a hp-negative age-matched control group. nodular antritis was observed in 70.4% of the hp-positive patients and 11.3% of the hp-negative group (p <0.001). the specificity of nodular antritis was 86.1%. a significant association was found between the existence of nodular a ... | 1993 | 8285457 |
| helicobacter pylori infection, cigarette smoking and alcohol consumption. a histological and clinical study on 286 subjects. | helicobacter pylori (hp) is connected with active/chronic gastritis, gastric gastric and duodenal ulcer. it is not known whether exogenous factors are involved in hp infection. the aim of this prospective study, performed on 286 consecutive subjects undergoing upper gastrointestinal endoscopy, was to evaluate the influence of smoking and alcohol consumption on hp infection. for each patient the following parameters were taken into account: sex, age, smoking (no, < 10, > 10 cig/day) and alcohol ( ... | 1993 | 8286775 |
| gastrointestinal infection in children. | infections of the gastrointestinal tract remain an important cause of childhood morbidity and mortality worldwide. a number of pertinent articles have appeared in the past year, advancing our understanding of 1) helicobacter pylori-induced gastroduodenal disease, 2) escherichia coli o157:h7-mediated diarrhea, and 3) newer gastrointestinal parasites that cause diarrhea. these are the topics of review. | 1993 | 8287081 |
| reinfection or recrudescence after apparently successful eradication of helicobacter pylori infection: implications for treatment of patients with duodenal ulcer disease. | helicobacter pyloris is considered to be aetiologically implicated in gastritis and peptic ulceration, since if h. pyloris infection can be eradicated the risk of subsequent ulcer relapse is markedly reduced. the rate of 'reinfection' following treatment ranges from 0% to 45%, but its origin remains controversial (reappearance of uneradicated original infection or a fresh infection). to distinguish temporary suppression of h. pylori from fresh infection we conducted a retrospective analysis of t ... | 1993 | 8171185 |
| helicobacter pylori-associated gastritis and gastric carcinoma in beijing. | a retrospective study was performed on 500 consecutive gastric biopsies obtained from patients with a diagnosis of gastritis and gastric carcinoma. overall, helicobacter pylori was detected in 336 cases (67.2%); it was seen in 82.4% of patients with duodenal ulcer, 80.1% of patients with gastric ulcer, 76.1% of patients with chronic atrophic gastritis, 60.3% of patients with chronic superficial gastritis, and 32.1% of patients with gastric carcinoma. the gastric epithelium colonized by helicobac ... | 1993 | 8189377 |
| effect of lansoprazole on helicobacter pylori. | helicobacter pylori has been identified as a major factor in duodenal ulcerogenesis. after h pylori eradication, the recurrence rate of duodenal ulcers falls dramatically and cure of this chronic relapsing disease has been claimed by several authors. h pylori eradication was first attempted with bismuth salts alone or with antibiotics. h2-receptor antagonists are not effective against h pylori, although proton pump inhibitors such as omeprazole and lansoprazole are active in vitro against h pylo ... | 1993 | 8205593 |
| rationale for eradication of helicobacter pylori infection in duodenal ulcer disease. | helicobacter pylori is presently considered a major factor predisposing to the development of duodenal ulceration. the risk of duodenal disease is increased up to 15-fold in patients with h pylori-associated gastritis compared with individuals without h pylori infection. this magnitude of risk with h pylori infection is higher than that of any other known or postulated factor contributing to duodenal ulcer formation. to reclassify duodenal ulcer disease from simply being an acid-related disease ... | 1993 | 8205594 |
| lansoprazole and helicobacter pylori infection. | helicobacter pylori-associated gastritis is present in virtually all patients with duodenal ulcer (du). eradication of h pylori is associated with a highly significant decline in the recurrence rates of du, indicating that treatments aimed at eradicating h pylori are mandatory in these patients. the novel proton pump inhibitor lansoprazole exhibits a potent antiulcer effect and, in vitro, a direct antibacterial effect against h pylori. conflicting data have been reported on the question of wheth ... | 1993 | 8205595 |
| evaluation of a commercial enzyme-linked immunosorbent assay (elisa) kit for serological diagnosis of helicobacter pylori infection in a group of non-ulcer dyspepsia sufferers. | helicobacter pylori infection of the stomach is associated with gastritis and peptic ulceration and may be causative. a noninvasive test for this organism might be useful in managing some patients with dyspepsia without the need for further investigation. we have evaluated a new commercially available serological test (helico-g elisa, porton cambridge, uk) for this infection to assess its diagnostic accuracy in a retrospective study of 115 patients with non-ulcer dyspepsia. sixty-three of these ... | 1993 | 8208642 |
| [helicobacter pylori: to treat or not to treat?]. | 1993 | 8296521 | |
| [the significance of helicobacter pylori infection in the etiology of abdominal pain in children]. | chronic and recurrent abdominal pain are frequent diagnostic problems in school age and adolescent children. the authors examined the igg antibodies to helicobacter pylori using elisa in a group of 91 children. positive results were found in 20 children, i.e. 22%. all children positive for helicobacter pylori antibodies underwent an endoscopic examination with bioptic sampling of the gastric and duodenal mucosa. bioptic samples were examined histologically and helicobacter pylori was identified ... | 1993 | 8299193 |
| interferon-gamma and tumour necrosis factor production in patients with helicobacter pylori infection. | the production of the cytokines, interferon-gamma and tumour necrosis factor by human antral mucosa cells and stimulated peripheral blood mononuclear cells were determined by enzyme linked immunosorbent assay and l929 bioassay respectively. tumour necrosis factor production by peripheral blood mononuclear cells in response to helicobacter pylori stimulation was depressed in helicobacter pylori positive individuals, compared to helicobacter pylori negative individuals (p < 0.05). there was no dif ... | 1993 | 8300378 |
| helicobacter pylori infection in a randomly selected population, healthy volunteers, and patients with gastric ulcer and gastric adenocarcinoma. a seroprevalence study in taiwan. | to investigate the association of helicobacter pylori and gastric ulcer and adenocarcinoma, igg antibodies against h. pylori were examined in 823 randomly selected subjects, 92 healthy volunteers, 117 patients with gastric ulcer, and 148 with gastric adenocarcinomas in taiwan, where the prevalence of gastric adenocarcinoma is high. the seropositivity of this population in taiwan was 54.4%. gastric ulcer patients had a higher seropositivity (83.8%) than healthy volunteers (62.0%) and gastric aden ... | 1993 | 8303209 |
| detection of h. pylori in saliva using a monoclonal antibody. | the presence of helicobacter pylori in saliva specimens collected from infected children examined before and after specific therapy and from a non-infected pediatric population was detected by indirect immunofluorescence assay (iif) using a specific monoclonal antibody. among the 25 children with h. pylori-negative antral biopsies, 4 had in their salivas bacterial cells similar to h. pylori, but a retrospectively performed serologic test showed a positive response. no false-positive reaction was ... | 1993 | 8305804 |
| [helicobacter pylori: studies in domestic swine]. | in the course of 15 month, 240 stomachs from pigs slaughtered in three different slaughterhouses were examined for the presence of helicobacter pylori. in 52.5% of the stomachs, gram-negative curved or spiral shaped bacteria were found, which during the following biochemical analyses were demonstrated to be urease negative. helicobacter pylori could not be isolated from any of the stomachs. in addition, we conducted four separate experiments on five to eight weeks old piglets in order to determi ... | 1993 | 8306861 |
| detection in an enzyme immunoassay of an immune response to a recombinant fragment of the 128 kilodalton protein (caga) of helicobacter pylori. | the possibility of using a recombinant fragment of the caga (128 kda protein) for the diagnosis of helicobacter pylori infection was evaluated. following cloning of the gene coding for the caga, a recombinant fragment of it was expressed in escherichia coli, purified and used in western blot and an eia to screen sera from 82 patients with gastroduodenal disease who underwent endoscopic examination. in western blot, good correlation was found between the serological data obtained with the recombi ... | 1993 | 8307041 |
| effect of inoculum size on antimicrobial susceptibility of helicobacter pylori. | an agar dilution assay was used to assess the effect of inoculum size and culture period on the susceptibility of 15 clinical isolates of helicobacter pylori to ampicillin, erythromycin, tetracycline, chloramphenicol, metronidazole and tinidazole. the mean mic of the isolates increased 2.2- to 21.2-fold as the inoculum size progressed from 10(3) to 10(7) cfu/spot. identical results were noted when isolates were maintained for two or four days prior to testing. inoculum size should be carefully c ... | 1993 | 8307051 |
| prevalence of immunoglobulin g antibodies to helicobacter pylori in chilean individuals. | 1993 | 8307057 | |
| peptic ulcer: an infectious disease? | since the ingestion studies by marshall and morris, helicobacter pylori has been known to cause both acute and chronic infection in the human stomach activating both the cellular and the humoral immune system. it is of little or no value to evaluate the causative relationship of an infectious agent using koch's criteria. the more recent criteria for causative relationships used in the science of epidemiology are more useful. these criteria include: (i) the characteristic of the association which ... | 1993 | 8292307 |
| genetic diversity of helicobacter pylori indexed with respect to clinical symptomatology, using a 16s rrna and a species-specific dna probe. | dna probes are described which identify group and fingerprint strains of the human gastric pathogen helicobacter pylori, on the basis of well-defined band homologies. a 544 bp internal fragment of the 16s ribosomal rna gene was generated by polymerase chain reaction (pcr) with primers derived from the escherichia coli rrna gene sequence. in genomic southern blots this probe detected restriction site variation around these loci, generating simple but strain-specific molecular fingerprints. a smal ... | 1993 | 8294306 |
| heterotopic gastric mucosa and helicobacter pylori infection in meckel's diverticulum in indian subjects. | two of twenty nine (6.8%) patients who had undergone resection of meckel's diverticulum demonstrated heterotopic gastric mucosa. in both these patients gastric mucosa was of antral type. remaining 27 of 29 (93.2%) patients with meckel's diverticulum had intestinal mucosa. 9 of 29 (31%) patients with meckel's resected were symptomatic (8 bleeding, 1 perforation) and all 9 were negative for heterotopic gastric mucosa. helicobacter pylori (h. pylori) was absent in both patients with intestinal muco ... | 1993 | 8294325 |
| [the detection of helicobacter pylori by pcr in gastric diseases]. | there are several methods for detecting helicobacter pylori (h.pylori) infection, but all of them have both advantage and disadvantage. in this study, we investigated the usefulness of pcr as a routine screening method for h.pylori infection. we used pcr by identification of bacterial specific 16srrna gene. this test was performed on gastric biopsy specimens and gastric aspirate and stomatic mucus from 23 patients in gastric disease, and compared the sensitivity with other methods such as urease ... | 1993 | 8295342 |
| [comparison between elisa and culture method for detection of helicobacter pylori]. | detection of helicobacter pylori (h. pylori) by elisa was compared with that by the culture method in 115 patients with gastroduodenal diseases. both the sensitivity and specificity were more than 85% for patients with histological gastritis with neutrophil infiltration. this indicated that the detection of h. pylori by elisa is useful for the diagnosis of h. pylori-related gastritis. although the sensitivity between the elisa and culture method was 85%, the specificity was 58.8%. the false nega ... | 1993 | 8295343 |
| value of whole-cell antigen extracts for serologic detection of helicobacter pylori. | whole-cell protein extracts of helicobacter pylori strains were evaluated by enzyme-linked immunosorbent assay to detect immunoglobulin g antibody against h. pylori in 113 patients with upper gastrointestinal complaints. these antigen preparations were of value for detecting infection by h. pylori in patients with high antibody titers (> or = 12,800), whereas for patients with lower titers, the results were inconclusive. | 1993 | 8308132 |
| [occurrence of helicobacter pylori in mucous membrane of stomach in patients with duodenal ulcer and inflammation of stomach mucous membrane]. | in 1990-1991 microbiological studies were performed aimed at determination of frequency of occurrence of helicobacter pylori in patients treated because of peptic ulcer in department of gastroenterology in katowice. studies were performed in 112 patients. out of these, in 73 duodenal ulcer was detected endoscopically (group i), in 26--inflammation of stomach mucous membrane with erosion (group ii), and in 13--both duodenal ulcer and erosion of stomach membrane (group iii). samples from mucous me ... | 1993 | 8309298 |
| [effect of bismuth salts in elimination of helicobacter pylori from gastric mucosa in patients with duodenal ulcer]. | bismuth salts belong do basic drugs used for elimination of helicobacter pylori (hp), a microorganism which is postulated to participate in etiopathogenesis of duodenal ulcer. the study was aimed at evaluation of effectiveness of application of tripotassium bismuth citrate (ventrisol-polfa) in elimination of hp and its influence on treatment of the ulcer. in 30 patients with diagnosed endoscopically duodenal ulcer, ventrisol in tablets was applied (2 x 2); it was also used in its fluid form (4 x ... | 1993 | 8309299 |
| [prevention of recurrence of duodenal ulcer by eradication of helicobacter pylori. a major progress]. | 1993 | 8310227 | |
| [helicobacter pylori: new answers to old questions]. | infection with helicobacter pylori affects 20-40% of the adult population in advanced countries. a causal relationship between helicobacter pylori and gastritis type b was proved. there is some indirect conclusive evidence of an aetiological association with peptic gastroduodenal ulceration. attention is drawn to possible associations with gastric malignities. the author reviews aetiopathogenetic relations between helicobacter pylori infection and these diseases. | 1993 | 8310667 |
| helicobacter pylori: isolation from gastric biopsy specimens. | forty-two gastric biopsies, in two transport media, were homogenized and cultured on three media under micro-aerophilic conditions. brain-heart infusion agar with a commercial antibiotic supplement (giving 10 mg vancomycin, 5 mg trimethoprim and 2500 i.u. polymixin per litre) yielded the best results. ordinary chocolate (heated) human blood agar could be used in laboratories with limited resources. growth was obtained in 4-6 days at 37 degrees c. all isolates were sensitive to metronidazole. the ... | 1993 | 8311573 |
| helicobacter pylori infection in gastric cancer: a study of 84 cases from asir region. | gastric cancer can be divided into three histologic types: intestinal and diffuse adenocarcinoma, and malignant lymphoma. to determine whether helicobacter pylori was associated with either cancer type, we reviewed histologic sections from stomachs of 84 patients with the diagnosis of gastric. of 63 patients with histologic evidence of intestinal adenocarcinoma, 53 (84%) contained h. pylori n noncancerous tissue compared with six (66.7%) of nine patients with diffuse adenocarcinoma (odds ratio = ... | 1994 | 17586919 |
| peptic disease in childhood in asir province. | the records of 15 patients (10 females and five males) with peptic disease, i.e., peptic ulcer and/or chronic gastroduodenis who were endoscoped at asir central hospital between 1989g and 1991g were reviewed. the patients' ages ranged between two and 12 years. all the patients were studied radiologically by barium meal (except for two), followed by endoscopy. histopathology and culture for helicobacter pylori were done in six patients. thirty-three percent (five patients) and positive family his ... | 1994 | 17589077 |
| helicobacter pylori: prevalence in 352 consecutive patients with dyspepsia. | at the riyadh armed forces hospital (rafh), 352 patients had gastroscopy and from each, antral gastric biopsies were taken for identification of helicobacter pylori, by urease test and histopathology. in 217 (61.64%) of these 352 patients, the histology specimens showed helicobacter pylori in 73.68% of patients with duodenal ulcer, 70% of patients with gastric ulcers and gastric erosions, 61% of patients with duodenitis and 52% of patients with gastritis. the urease test was positive at six hour ... | 1994 | 17589079 |
| [peptic ulcer disease and helicobacter pylori. a comparative study of two different three-drug regimens.] | helicobacter pylori (h. pylori) is now known to be strongly associated with gastritis type b, duodenal ulcer, gastric ulcer and perhaps gastric cancer. to cure peptic ulcer disease has become reality. this prospective study included 60 patients, 41 male and 19 females, with long history of peptic ulcer disease (1 - 41 yr, mean 16.5 yr), diagnosed with active duodenal ulcer (50) or gastric ulcer (10) during endoscopy of the upper gastrointestinal tract. after a positive clo test and histologic co ... | 1994 | 21593529 |
| helicobacter pylori and duodenal ulcer: guilty as charged. | 1994 | 22346510 | |
| eradication therapy in duodenal ulcer. | a one-week course of treatment to eradicate helicobacter pylori heals duodenal ulceration in most infected patients without the need for anti-acid drugs, researchers from hong kong say. | 1994 | 27669610 |
| helicobacter pylori infection and food-cobalamin malabsorption. | two entities of considerable recent interest, helicobacter pylori infection of the stomach and food-cobalamin malabsorption, are each intimately associated with gastric abnormalities. a possible connection between the two entities thus suggested itself and prompted us to study 98 subjects with low serum cobalamin levels but normal schilling test results and 17 controls with normal cobalamin levels. food-cobalamin absorption was measured with the egg yolk-cobalamin absorption test (eycat) and was ... | 1994 | 8313813 |
| upper gastrointestinal endoscopy in central australian aborigines. | to examine the upper gastrointestinal endoscopic findings in australian aborigines in central australia; to determine if peptic ulceration occurs in this group; and to discover whether this population shares helicobacter pylori as a risk factor for peptic ulceration. | 1994 | 8309388 |
| susceptibility of helicobacter pylori to the antibacterial activity of manuka honey. | honey is a traditional remedy for dyspepsia, and is still used for this by some medical practitioners although there is no rational basis for its use. the finding that helicobacter pylori is probably the causative agent in many cases of dyspepsia has raised the possibility that the therapeutic action of honey may be due to its antibacterial properties. consequently, the sensitivity of helicobacter pylori to honey was tested, using isolates from biopsies of gastric ulcers. it was found that all f ... | 1994 | 8308841 |
| [helicobacter pylori positivity]. | 1994 | 8295777 | |
| one week's anti-helicobacter pylori treatment for duodenal ulcer. | this open study tested whether eradication of helicobacter pylori (h pylori) heals duodenal ulcers as well as decreasing recurrence. h pylori was detected in patients with endoscopic duodenal ulcers by histology, clo-test, culture, and 13c-urea breath test (13c-ubt). tripotassium dicitrato bismuthate (120 mg) and amoxycillin (500 mg) each four times daily, were given for seven days, with 400 mg metronidazole five times a day on days 5-7. the 13c-ubt was repeated immediately after treatment and e ... | 1994 | 8307442 |
| evidence for the essential role of helicobacter pylori in gastric ulcer disease. | helicobacter pylori (h pylori) eradication heals chronic active type b gastritis and dramatically changes the natural history of duodenal ulcer disease. there are few data concerning the role of anti-h pylori treatment in gastric ulcer disease. a total of 83 patients presenting with h pylori positive active gastric ulcer disease were treated with omeprazole and antibiotics (amoxicillin, ciprofloxacin, roxithromycin) in seven different clinical protocols, each of which included the attempt to era ... | 1994 | 8307443 |
| helicobacter pylori stimulates antral mucosal reactive oxygen metabolite production in vivo. | to determine if reactive oxygen metabolites have a pathogenic role in helicobacter pylori (h pylori) related gastroduodenal disease, this study measured their production in antral mucosal biopsy specimens. two related chemiluminescence techniques were used comparing h pylori positive (n = 105) and negative patients (n = 64) with a similar spectrum of macroscopic disease. after chemiluminescence assays, biopsy specimens were graded histologically. increased luminol dependent chemiluminescence (de ... | 1994 | 8307467 |
| one-year follow-up of duodenal ulcers after 1-wk triple therapy for helicobacter pylori. | to study the ulcer recurrence rate of helicobacter pylori-positive duodenal ulcers at 1 yr after eradication of the bacteria by triple therapy. | 1994 | 8304303 |
| helicobacter pylori infection and development of gastric or duodenal ulcer in arthritic patients receiving chronic nsaid therapy. the misoprostol study group. | helicobacter pylori infection and nonsteroidal anti-inflammatory drug use are both common causes of peptic ulcer. it remains unclear whether h. pylori/nsaid interactions occur, and if they do, with what result(s). | 1994 | 8304304 |
| establishment of a small animal model for human helicobacter pylori infection using germ-free mouse. | to understand why oral inoculation of helicobacter pylori resulted in continuous colonization of the stomach in germ-free athymic mice, but only temporary colonization in mice that were not germ-free. | 1994 | 8304305 |
| sulglycotide effect on the proteolytic and lipolytic activities of helicobacter pylori toward gastric mucus. | infection with helicobacter pylori is now recognized as a major factor in the etiology of gastric disease, and among the detrimental effects this bacterium exerts on the mucosal integrity is the elaboration of extracellular protease and lipase enzymes capable of mucus protein and lipids degradation. we present here evidence that the activities of these enzymes are inhibited by an gastroprotective agent, sulglycotide. | 1994 | 8304309 |
| sex ratio of helicobacter pylori infection in childhood. | 1994 | 8304332 | |
| helicobacter pylori gastritis in dyspeptic children. a long-term follow-up after treatment with colloidal bismuth subcitrate and tinidazole. | the connection between dyspeptic symptoms and helicobacter pylori infection was studied prospectively in 21 children treated for verified h. pylori infection with bismuth subcitrate and tinidazole. gastroscopy with biopsy was performed before and a mean of 4 months after discontinuation of the treatment. a second post-treatment check with determination of h. pylori antibodies and serum pepsinogen 1 level was made a mean of 1.5 years after cessation of treatment. the therapy given cleared the bac ... | 1994 | 8209177 |
| helicobacter pylori infection in north-eastern peninsular malaysia. evidence for an unusually low prevalence. | the prevalence of helicobacter pylori infection was determined in peptic ulcer patients, in non-ulcer dyspepsia (nud) patients, and in the general adult population. the h. pylori infection rate ascertained by microbiologic examination of multiple gastric antral biopsy specimens was 50% (17 of 34) in duodenal ulcer (du), 5% (1 of 22) in gastric ulcer, and 9% (15 of 159) in nud patients. a seroepidemiologic survey showed a prevalence of only 4.2% among 496 blood donors and 4.8% among 921 subjects ... | 1994 | 8209178 |
| gastric mucosal injury: microcirculation and helicobacter pylori. | the integrity of gastric mucosa is well-balanced by an array of defensive mechanisms which protect the mucosa against external aggressive factors. when excessive stimulation of autonomic nervous system (irritation) is induced, microcirculatory disturbances easily lead to the gastric mucosal damage due to the formation of vasoactive mediators and oxygen radicals. in this review, our discussion has been focused on the co-ordinating function of the autonomic nervous system as well as the microcircu ... | 1994 | 8189675 |
| nonopsonic activation of neutrophils and cytotoxin production by helicobacter pylori: ulcerogenic markers. | fifty-four clinical isolates of helicobacter pylori from human gastric biopsy specimens were tested for cytotoxin production, as determined by intracellular vacuolization of hela cells, and for the induction of oxidative burst in human polymorphonuclear leukocytes (pmnls), as measured by luminol-enhanced chemiluminescence (cl). nonopsonized, 20 of the h. pylori strains induced a rapid and strong cl response, in contrast to 30 other strains, which showed only weak and slow responses. another four ... | 1994 | 8171279 |
| helicobacter pylori-associated gastritis and dyspepsia. the influence on migrating motor complexes. | twenty-five patients with dyspepsia were included. in 19 patients with a median age of 48 (range, 20-72) years endoscopy and histologic examination of biopsy specimens from the antrum and corpus of the stomach showed helicobacter pylori-positive gastritis as the only pathologic finding. in six patients with a median age of 42 (range, 32-56) years h. pylori-negative gastritis was found. after an overnight fast the patients underwent an ambulatory duodenal motility study for 6-8 h. twenty-five you ... | 1994 | 8171280 |
| helicobacter pylori in dyspeptic children and adults: endoscopic, bacteriologic and histologic correlations. | using different bacteriological (urease test, gram staining and culture) and histological (steiner staining and modified giemsa staining) techniques, we searched for the presence of helicobacter pylori in the gastric antrum of 200 dyspeptic brazilian patients (106 females and 94 males aged 19 days to 81 years). the presence of bacteria was then correlated with the endoscopic and histological findings. h. pylori was present in 59.5% of the population studied. in brazil, colonization occurs early, ... | 1994 | 8524059 |
| helicobacter pylori infection as a cause of gastritis, duodenal ulcer, gastric cancer and nonulcer dyspepsia: a systematic overview. | to evaluate current evidence for a causal relation between helicobacter pylori infection and gastritis, duodenal ulcer, gastric cancer and nonulcer dyspepsia. | 1994 | 8287340 |
| indications for treatment of helicobacter pylori infection: a systematic overview. | to determine (a) the advantages and disadvantages of treatment options for the eradication of helicobacter pylori and (b) whether eradication of h. pylori is indicated in patients with duodenal ulcer, nonucler dyspepsia and gastric cancer. | 1994 | 8287341 |
| an etiologic approach to management of duodenal and gastric ulcers. | with rare exception, peptic ulcers can now be classified as either helicobacter pylori-related, induced by nonsteroidal anti-inflammatory drugs (nsaids), or related to zollinger-ellison syndrome. helicobacter pylori-related ulcers can be treated by eradication of h pylori or by traditional therapies, including antisecretory drugs or sucralfate. successful eradication of h pylori requires compliance with a multidrug regimen. therefore, candidates should demonstrate substantial motivation. in gene ... | 1994 | 8289053 |
| lymphocytic gastritis: a positive relationship with celiac disease. | lymphocytic gastritis is characterized by lymphocytic infiltration of the surface and pit epithelium. its cause has not been established, but an association with helicobacter pylori infection or celiac disease has been suggested. we evaluated the histologic features of both gastric and duodenal biopsy specimens from 245 consecutive children and adolescents, and found chronic gastritis in 60 children and celiac disease in 25. chronic gastritis was associated with h. pylori infection in 36 childre ... | 1994 | 8283376 |
| helicobacter pylori infection in infants born from positive mothers. | 1994 | 8273790 | |
| use of high efficacy, lower dose triple therapy to reduce side effects of eradicating helicobacter pylori. | to evaluate two triple-therapy (tt) regimens of colloidal bismuth subcitrate (cbs), metronidazole, and tetracycline hcl in eradicating helicobacter pylori, with particular attention to the frequency of resulting adverse effects of the two therapies. | 1994 | 8273794 |
| medium-term results of oral and intravenous omeprazole/amoxicillin helicobacter pylori eradication therapy. | the aim of the present study was to examine the effect of the application route of the antibiotic amoxicillin in helicobacter pylori eradication, using omeprazole/amoxicillin. | 1994 | 8273795 |
| [optimal treatment of helicobacter pylori infections is not known. more clinical trials on elimination are necessary]. | 1994 | 8189935 | |
| [a new clinical strategy in peptic ulcer disease. suggestions for the elimination of helicobacter pylori]. | 1994 | 8189937 | |
| [diagnosis of helicobacter pylori infection]. | 1994 | 8189938 | |
| [indications for therapy against helicobacter pylori]. | 1994 | 8189939 | |
| [duodenal ulcer disease: a defect in the secretory immune response to helicobacter pylori?]. | in a prospective study we examined 20 helicobacter pylori (hp)-positive duodenal ulcer patients (5 female, 15 male; age 26-70 [mean 43] years), 20 hp-positive patients with non-ulcer dyspepsia (10 female, 10 male; age 26-79 [mean 48] years) and 10 hp-negative patients with non-ulcer dyspepsia (5 female, 5 male; age 21-76 [mean 45] years) during upper gi-endoscopy. hp was detected by histology (h&e, giemsa), rapid urease test (clo) and serology (cobas core anti-h. pylori eia). iga anti-hp in gast ... | 1994 | 8191263 |
| [suppression of helicobacter pylori by local secretory immune response?]. | 54 patients (22 females, 32 males, age 21-79, mean 45 years) referred for upper gastrointestinal endoscopy were investigated. helicobacter pylori (hp) infection was determined using histology (h&e and giemsa stain), rapid urease test (clo) and serology (cobas core anti-h. pylori eia). density of hp colonization was determined in gastric antral (3 biopsy specimens) and body mucosa (2 biopsy specimens) and semiquantitatively graded on a scale of 0 to 3. gastric colonization was obtained by additio ... | 1994 | 8191264 |
| [alternatives of drug therapy in helicobacter pylori infections]. | the last three years of research on treatment of helicobacter pylori infection support the recommendations made by the working party, world congress of gastroenterology 1990. meta-analysis shows a noteworthy difference between the recommended regimens favouring the combination of bismuth, metronidazole and tetracycline. no regimen without bismuth has been shown to have a sustained helicobacter pylori eradication rate exceeding 90%, nor has any alternative regimen been shown convincingly to stem ... | 1994 | 8191471 |