Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| development and evaluation of a gal4-mediated luc/gfp/gus enhancer trap system in arabidopsis. | gal4 enhancer trap systems driving expression of lacz and gfp reporters have been characterized and widely used in drosophila. however, a gal4 enhancer trap system in arabidopsis has not been described in the primary literature. in drosophila, the reporters possess a gal4 upstream activation sequence (uas) as five repeats (5xuas) and lines that express gal4 from tissue specific enhancers have also been used for the ectopic expression of any transgene (driven by a 5xuas). while gal4 transactivati ... | 2005 | 15941484 |
| adenylate kinase of escherichia coli, a component of the phage t4 dntp synthetase complex. | adenylate kinase, which catalyzes the reversible atp-dependent phosphorylation of amp to adp and damp to dadp, can also catalyze the conversion of nucleoside diphosphates to the corresponding triphosphates. lu and inouye (lu, q., and inouye, m. (1996) proc. natl. acad. sci. u. s. a. 93, 5720-5725) showed that an escherichia coli ndk mutant, lacking nucleoside diphosphate kinase, can use adenylate kinase as an alternative source of nucleoside triphosphates. bacteriophage t4 can reproduce in an es ... | 2005 | 15941717 |
| cardiac and renal antioxidant enzymes and effects of tempol in hyperthyroid rats. | this study evaluated the activity of cardiac and renal antioxidant enzymes [superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx), and glutathione reductase (gr)] and whether chronic treatment with tempol, a cell membrane-permeable sod mimetic, ameliorates the hypertension of hyperthyroidism. two experiments were performed. in experiment i, the following four groups of male wistar rats were used: control group and three groups that received thyroxine (t4) at 10, 50, or 75 micr ... | 2005 | 15941780 |
| sympatho-vagal control of heart rate variability in patients treated with suppressive doses of l-thyroxine for thyroid cancer. | this study aimed to analyze the autonomic control of heart rate variability (hrv) in subjects receiving chronic l-thyroxine (l-t4) treatment after total thyroidectomy and (131)i therapy for differentiated thyroid carcinoma. | 2005 | 15941920 |
| transcriptional takeover by sigma appropriation: remodelling of the sigma70 subunit of escherichia coli rna polymerase by the bacteriophage t4 activator mota and co-activator asia. | activation of bacteriophage t4 middle promoters, which occurs about 1 min after infection, uses two phage-encoded factors that change the promoter specificity of the host rna polymerase. these phage factors, the mota activator and the asia co-activator, interact with the sigma(70) specificity subunit of escherichia coli rna polymerase, which normally contacts the -10 and -35 regions of host promoter dna. like host promoters, t4 middle promoters have a good match to the canonical sigma(70) dna el ... | 2005 | 15941982 |
| the accuracy of endoscopic ultrasonography with fine-needle aspiration, integrated positron emission tomography with computed tomography, and computed tomography in restaging patients with esophageal cancer after neoadjuvant chemoradiotherapy. | patients with esophageal cancer who receive neoadjuvant chemoradiotherapy are restaged with computed tomography (ct), endoscopic ultrasound with fine needle aspiration (eus-fna), and integrated positron emission computed tomography (fdg-pet/ct), and the results affect treatment. | 2005 | 15942562 |
| integrated computed tomography-positron emission tomography in patients with potentially resectable malignant pleural mesothelioma: staging implications. | integrated computed tomography-positron emission tomography imaging with coregistration of anatomic and functional imaging data may improve the accuracy of malignant pleural mesothelioma staging. we evaluate the use of integrated computed tomography-positron emission tomography in patients with malignant pleural mesothelioma who are being considered for extrapleural pneumonectomy. | 2005 | 15942579 |
| thyroid function in nestling tree swallows and eastern bluebirds exposed to non-persistent pesticides and p, p'-dde in apple orchards of southern ontario, canada. | this study examined the associated effects of pesticides and persistent residues of p,p'-dde on thyroid function in 16-day-old tree swallows (tachycineta bicolor) and 12-day-old eastern bluebirds (sialia sialis). apple orchards sprayed with pesticides in current use and reference sites were chosen for study in southern ontario, canada, during 2000-2001. we assessed thyroid hormone concentrations (plasma and muscle thyroxine [t4], and triiodothyronine [t3]) and the response to a challenge with th ... | 2005 | 15943111 |
| decreased type 1 iodothyronine deiodinase expression might be an early and discrete event in thyroid cell dedifferentation towards papillary carcinoma. | type i iodothyronine deiodinase (d1) catalyses the 5' monodeiodination of t4 and is highly expressed in normal human thyroid gland. we have investigated d1 expression in a series of benign and malignant differentiated thyroid neoplasias. | 2005 | 15943828 |
| [correlation of clusterin expression to prognosis of bladder carcinoma]. | clinically, molecular prognostic markers for bladder carcinoma are still rare. recently, up-regulation of clusterin protein has been suggested to relate with development and prognosis of several human cancers, but its relation with bladder cancer is unclear. this study was to analyze correlation of expression of clusterin protein to clinicopathologic parameters and prognosis of bladder cancer with tissue chip. | 2005 | 15946493 |
| [hypothyroidism following cervical irradiation in the management of carcinoma of the nasopharynx and of the breast: a prospective study on eighty-four cases]. | 1/ to evaluate the incidence of hypothyroidism following radiotherapy in the management of breast and nasopharyngeal carcinomas, 2/ to define the role of a systematic post therapeutic screening. | 2005 | 15946882 |
| exposure to bisphenol a is associated with recurrent miscarriage. | little is known about the influence of high exposure to bisphenol a on recurrent miscarriage and immunoendocrine abnormalities. | 2005 | 15947000 |
| life expectancy in differentiated thyroid cancer: a novel approach to survival analysis. | in differentiated thyroid carcinoma 10-year survival rates amount to 80-95%. because age at diagnosis varies widely, these survival rates strongly depend on age at presentation. the aim of the present study was to analyse the attributable risk factors, including therapy per se, on survival in thyroid cancer after proper adjustment for the baseline mortality rate in the general population and to elucidate the adverse treatment effects on survival. initial treatment in 504 patients consisted of th ... | 2005 | 15947102 |
| thyroid hormone receptor-beta-selective agonist gc-24 spares skeletal muscle type i to ii fiber shift. | triiodothyronine (t3) is known to play a key role in the function of several tissues/organs via the thyroid hormone receptor isoforms alpha (tralpha) and beta (trbeta). we have investigated the effects of gc-24, a novel synthetic trbeta-selective compound, on skeletal muscle fiber-type determination, cross-sectional area, and gene expression in rat skeletal muscles. for fiber typing, cross sections of soleus and extensor digitorum longus (edl) muscles were stained for myosin atpase activity at v ... | 2005 | 15947969 |
| plasma adiponectin and insulin resistance in women with polycystic ovary syndrome. | to determine plasma adiponectin concentration in women with and without polycystic ovary syndrome (pcos) and to assess possible correlations of adiponectin to the hormonal and metabolic parameters, including measures of insulin resistance (ir). | 2005 | 15950640 |
| effects of bisphenol-a (bpa), dibutylphtalate (dbp), benzophenone-2 (bp2), procymidone (proc), and linurone (lin) on fat tissue, a variety of hormones and metabolic parameters: a 3 months comparison with effects of estradiol (e2) in ovariectomized (ovx) rats. | the endocrine active substances bpa, dbp and bp2 have estrogenic effects in the uterus. proc and lin were shown to be antiandrogenic. whether other estrogen-regulated parameters like lipids, fat metabolism and hormones are also affected by these substances is unknown. we compared the effects of a 3 months lasting administration of these substances with those of e2 on an estrogen-regulated fat depot and on serum tsh, t3, t4, lh, and lipid concentrations. bp2 shared many of the effects of e2 by su ... | 2005 | 15951094 |
| elucidation of degradation mechanism of dioxins during mechanochemical treatment. | model dioxin compounds 4-chlorobiphenyl (4cb), octa-chlorodibenzo-p-dioxin (ocdd), and octachlorodibenzofuran (ocdf) were degraded by a mechanochemical (mc) process that involved milling with calcium oxide by use of a planetary ball mill. the degradation of 4cb produced mainly chloride ions and biphenyl, with the chlorine removal efficiency reaching about 100%. biphenyl was transformed into terphenyls, quaterphenyls, cyclohexylbenzene, and bicyclohexyl through polymerization and hydrogenation re ... | 2005 | 15952388 |
| the effect of cervical x-irradiation on activity index of thyrocytes and plasma tsh: a pre-clinical model for radiation-induced thyroid damage. | because radiotherapy in the head and neck region is necessary in the treatment of childhood cancer, possibilities to prevent damage to the thyroid gland must be explored. we developed a model in which radiation-induced effects can be investigated in a way that these effects can be quantified, using thyroid dysmorphology and plasma tsh. thirty-five wistar rats, 5 weeks old, were x-irradiated on the cervical region, with a single dose varying from 0 to 20 gy. after 6 weeks, tsh, t4 and t3 were det ... | 2005 | 15952412 |
| effect of long term feeding of ammoniated wheat straw treated with or without hcl on blood biochemical parameters in growing male buffalo (bubalus bubalis) calves. | twenty-four growing male buffalo calves (one year of age; 88.54 +/- 3.81 kg average body weight) were divided into three comparable groups (i, ii and iii) on the basis of their body weight (bw) in a completely randomised design to study the effect of long term feeding of ammoniated wheat straw (aws) and hydrochloric acid treated ammoniated wheat straw (hcl-aws) on blood biochemical changes. the animals were offered a concentrate mixture (cm) along with wheat straw (ws), ammoniated wheat straw (a ... | 2005 | 15952422 |
| a case of hypothyroidism and type 2 diabetes associated with type v hyperlipoproteinemia and eruptive xanthomas. | primary hypothyroidism and type 2 diabetes are both typically associated with the increased level of triglycerides. to date, there have been only a few case reports of type 2 diabetes patients with both type v hyperlipoproteinemia and eruptive xanthomas, but there have been no reports of hypothyroidism patients associated with eruptive xanthomas. we report here on a case of a 48-yr old female patient who was diagnosed with type 2 diabetes and primary hypothyroidism associated with both type v hy ... | 2005 | 15953878 |
| long-term follow-up of severely resorbed maxillary incisors after resolution of an etiologically associated impacted canine. | resorption of maxillary incisor roots because of an impacted canine is a well-recognized phenomenon that occurs in a surprisingly high proportion of patients with impacted canines. in this retrospective study, we studied a sample of patients in whom the resorption was particularly severe. | 2005 | 15953888 |
| psychogenic and pharmacologic induction of the let-down reflex can facilitate breastfeeding by tetraplegic women: a report of 3 cases. | although an increasing number of women are becoming pregnant and rearing children after spinal cord injury (sci), scant literature exists on breastfeeding after injury. in particular, it is unclear whether women with sci above t7 can sustain breastfeeding in a manner similar to neurologically intact nursing mothers. a functional let-down reflex is required to provide adequate milk to a nursing infant. infant suckling activates tactile receptors in the breast, and this signal is carried via affer ... | 2005 | 15954070 |
| decreased expression of retinoid nuclear receptor (rar alpha and rar gamma) mrna determined by real-time quantitative rt-pcr in peripheral blood mononuclear cells of hypothyroid patients. | in vivo assessment of the cellular impact of thyroid hormones on target tissues might be of help for physiological studies and to evaluate the consequences of various diseases of the thyroid gland in humans. given the tenuous relationship between retinoid and tri-iodothyronine (t3) status and that retinoids have also intracellular roles, the aim of this study was to determine the effect of hypothyroidism on the expression of t3 nuclear receptors (tr) and retinoic acid nuclear receptors (rar, rxr ... | 2005 | 15956352 |
| expression of recombinant membrane-bound type i iodothyronine deiodinase in yeast. | the bioactivity of thyroid hormone is determined to a large extent by the monodeiodination of the prohormone thyroxine (t4) by the hepatic selenoenzyme type i iodothyronine deiodinase (d1), i.e. by outer ring deiodination (ord) to the active hormone triiodothyronine (t3) or by inner ring deiodination (ird) to the inactive metabolite reverse t3 (rt3). since d1 is a membrane-bound protein with an n-terminal membrane-spanning domain, the enzyme is very difficult to purify in an active state. this s ... | 2005 | 15956354 |
| effect of daidzein on egg-laying performance in shaoxing duck breeders during different stages of the egg production cycle. | the effect of a phyto-oestrogen, daidzein, on the laying performance of shaoxing female ducks was examined in three experiments performed at different stages of the egg production cycle. egg-laying rate, egg weight, egg composition, feed conversion ratio, hatchability characteristics of eggs and body weight, ovary and oviduct weight, as well as changes in serum concentrations of t3, t4 and e2 were recorded as response criteria. in the first experiment, 68 young ducks, 100 d of age, were given a ... | 2005 | 15957437 |
| patterns of allelic loss of synchronous adenocarcinomas of the lung. | distinction of multiple primary lung carcinomas from intrapulmonary metastases using empiric clinical and histopathologic criteria can be difficult. recent advances have provided several molecular markers that can be used for clonal analysis of separate tumor nodules and enhance tumor staging and subsequent treatment and prognosis. to address this issue, we performed a microdissection-based allelotyping of 20 cases of histologically similar, pathologic stage t4 adenocarcinomas (adcs). loss of he ... | 2005 | 15958854 |
| pedicle screw placement in the thoracic spine: a comparison of image-guided and manual techniques in cadavers. | a cadaveric study comparing image guidance technology to fluoroscopic guidance as a means of pedicle screw placement in the thoracic spine, using a unique starting point for screw placement. | 2005 | 15959355 |
| dimethoate effects on thyroid function in suckling rats. | the aim of our work is to study dimethoate effects on thyroid function given in drinking water (40 mg/kg body weight, equivalent to 0.2 g/l) to mothers from day zero until the 10th day after delivery. pups and their mothers were sacrificed on day ten after parturition. compared to a control group, dimethoate-treated pups showed a 48% decrease in body weight which could be attributed to a defect in thyroid hormones. indeed, after treatment by dimethoate, plasma rates of free t4 and t3 decreased b ... | 2005 | 15959409 |
| analysis of extrahepatic bile duct carcinomas according to the new american joint committee on cancer staging system focused on tumor classification problems in 222 patients. | although the sixth edition of the american joint committee on cancer (ajcc) staging system for extrahepatic bile duct carcinoma was updated, the system has a problem on t classification due to its ambiguous definition of t1 as "tumor confined to bile duct histologically" and t2 as "tumor invading beyond the bile duct." | 2005 | 15959914 |
| carcinoma of the external auditory canal. | carcinoma of the external auditory canal is one of the most inaccessible areas of the body. it is a rare malignant neoplasm with an aggressive nature and an overall poor prognosis. in a ten year period, 16 patients were treated in king chulalongkorn memorial hospital. from tnm staging proposed by the university of pittsburgh, the authors found t1 = 1, t2 = 6, t3 = 5, t4 = 4 cases. in 14 patients who were operated on (radical mastoidectomy in 8, lateral temporal bone resection in 5, sleeve resect ... | 2005 | 15960229 |
| phosphorylated extracellular signal-regulated kinase 1/2 immunoreactivity identifies a novel subpopulation of sympathetic preganglionic neurons. | distinct chemical codes are thought to reflect functional specificity in sympathetic preganglionic neurons (spn). although a number of chemical candidates have been identified including neurotransmitter-related, calcium-binding and other proteins, signal transduction proteins have been largely neglected. not only might these chemicals allow discrimination of functionally unique chemical signatures, but they may also identify activated neurons. immunoreactivity (ir) to phosphorylated extracellula ... | 2005 | 15885917 |
| serum 3,3',5'-triiodothyronine (rt3) and 3,5,3'-triiodothyronine/rt3 are prognostic markers in critically ill patients and are associated with postmortem tissue deiodinase activities. | critical illness is associated with reduced tsh and thyroid hormone secretion, and with changes in peripheral thyroid hormone metabolism, resulting in low serum t3 and high rt3. in 451 critically ill patients who received intensive care for more than 5 d, serum thyroid parameters were determined on d 1, 5, 15, and last day (ld). all patients had been randomized for intensive or conventional insulin treatment. seventy-one patients died, and postmortem liver and skeletal muscle biopsies were obtai ... | 2005 | 15886232 |
| transient hypothyroxinemia in preterm infants: the role of cord sera thyroid hormone levels adjusted for prenatal and intrapartum factors. | transient hypothyroxinemia is common in infants less than 30 wk gestation and is associated with neurodevelopmental deficits; it has no consensus definition. we previously suggested that appropriate ranges for postnatal serum t4 values are at least cord levels corrected to an equivalent gestational age if the fetuses had remained in utero. | 2005 | 15886240 |
| toxicity of a phytosterol mixture to grayling (thymallus thymallus) during early developmental stages. | the study concerns the toxicity of a phytosterol mixture, ultrasitosterol, consisting mainly of beta-sitosterol 75.7% and beta-sitostanol 13.0%, to grayling (thymallus thymallus) embryos. eyed eggs were exposed to three concentrations (1 microg/l, 10 microg/l, and 50 microg/l) of ultrasitosterol for 4 weeks. embryos and later on hatched fry were taken for triiodothyronine (t3), thyroxine (t4), and histopathological analyses after 7, 14, 21, and 28 days of exposure. most of the eggs (>95%) hatche ... | 2005 | 15886854 |
| [thyroidectomy associated with laryngectomy in laryngeal cancer treatment. is it routinely necessary?]. | in patients with laryngeal invasive epidermoid carcinoma who are candidates for total laryngectomy, it is recommended to resect en bloc at least half of the thyroid gland on the same side as the laryngeal tumor with the objective of decreasing local recurrence associated with thyroid infiltration. nevertheless, in the histopathologic analysis of the specimen, a minority of thyroid glands show tumor infiltration. the fact that in these patients even partial thyroid resection is associated with hy ... | 2005 | 15888262 |
| an altered-specificity dna-binding mutant of escherichia coli sigma70 facilitates the analysis of sigma70 function in vivo. | the sigma subunit of bacterial rna polymerase is strictly required for promoter recognition. the primary (housekeeping) sigma factor of escherichia coli, sigma(70), is responsible for most of the gene expression in exponentially growing cells. the fact that sigma(70) is an essential protein has complicated efforts to genetically dissect the functions of sigma(70). to facilitate the analysis of sigma(70) function in vivo, we isolated an altered-specificity dna-binding mutant of sigma(70), sigma(7 ... | 2005 | 15882415 |
| transition from nonspecific to specific dna interactions along the substrate-recognition pathway of dam methyltransferase. | dna methyltransferases methylate target bases within specific nucleotide sequences. three structures are described for bacteriophage t4 dna-adenine methyltransferase (t4dam) in ternary complexes with partially and fully specific dna and a methyl-donor analog. we also report the effects of substitutions in the related escherichia coli dna methyltransferase (ecodam), altering residues corresponding to those involved in specific interaction with the canonical gatc target sequence in t4dam. we have ... | 2005 | 15882618 |
| correlation between histologic findings and cytogenetic abnormalities in bladder carcinoma: a fish study. | to investigate the chromosomal abnormalities present in bladder carcinoma using a fluorescence in situ hybridization assay and to correlate the genetic findings with the pathologic grade and stage. | 2005 | 15882723 |
| endocrine response of the freshwater teleost, sarotherodon mossambicus (peters) to dimecron exposure. | the endocrine response in a freshwater teleost, sarotherodon mossambicus (peters) under dimecron (an organophosphate pesticide) toxicity was investigated by estimating the serum levels of t3 (triiodothyronine), t4 (thyroxine), cortisol, prolactin and insulin in control and sub-lethal (0.001 ml l(-1)) dimecron-exposed fish for 1, 6, 12, 24h and 5 days. in control s. mossambicus, the serum levels of t3 ranged from 0.80+/-0.01 to 0.82+/-0.01 ng ml(-1); t4 from 2.20+/-0.01 to 2.25+/-0.01 microg dl(- ... | 2005 | 15882891 |
| [malignant paranasal sinus tumors. diagnosis, therapy and results]. | malignant neoplasmas of the paranasal sinuses are rare and present usually in advanced tumor stage due to the lack of early clinical symptoms. | 2005 | 15883842 |
| evaluation of photolyase (photosome) repair activity in human keratinocytes after a single dose of ultraviolet b irradiation using the comet assay. | photosome is constituted of photolyases included in liposomes. photolyase is a bacterial enzyme that can repair ultraviolet b (uvb)-induced cyclobutane pyrimidine dimers (cpd) in eukaryotic cells. a modified version of the alkaline comet assay has been set up to evaluate the repair activity of this enzyme after a single dose of uvb (312 nm, 0.06 j/cm2) in human keratinocytes. the formation of single strand breaks (ssb) induced by the uva photoactivation of the enzyme (1.2 j/cm2) was inhibited by ... | 2005 | 15878115 |
| structural and functional similarities between the capsid proteins of bacteriophages t4 and hk97 point to a common ancestry. | gene product (gp) 24 of bacteriophage t4 forms the pentameric vertices of the capsid. using x-ray crystallography, we found the principal domain of gp24 to have a polypeptide fold similar to that of the hk97 phage capsid protein plus an additional insertion domain. fitting gp24 monomers into a cryo-em density map of the mature t4 capsid suggests that the insertion domain interacts with a neighboring subunit, effecting a stabilization analogous to the covalent crosslinking in the hk97 capsid. seq ... | 2005 | 15878991 |
| renal cell carcinoma with renal vein and inferior vena caval involvement: clinicopathological features, surgical techniques and outcomes. | we present a contemporary review of patients with renal cell carcinoma (rcc) in whom renal vein/inferior vena caval thrombus was treated with radical nephrectomy and thrombectomy. | 2005 | 15879771 |
| treatment results of 1070 patients with nasopharyngeal carcinoma: an analysis of survival and failure patterns. | the aim of this analysis was to evaluate the outcomes of patients with nasopharyngeal carcinoma (npc) treated primarily by external beam irradiation (ert) and to explore for possible ways to improve the treatment results. | 2005 | 15880410 |
| total mesorectal excision: the heidelberg results after tme. | the introduction of the total mesorectal excision (tme) has changed the treatment of rectal cancer dramatically by reducing the local recurrence rate. we report the results of 208 patients undergoing a low anterior resection (lar, n = 180) or abdominoperineal resection (apr, n = 28) with tme between 1 october 2001 and 30 september 2003. no adjuvant therapy was administered to any patient; however, 108 patients received neoadjuvant radiotherapy or radiochemotherapy. since february 2002, 51 patien ... | 2005 | 15865026 |
| efficacy of hepatocellular carcinoma locoregional therapies on patients waiting for liver transplantation. | the aim of this study was to evaluate the efficacy of different locoregional therapies in patients with hcc on the waiting list for liver transplantation. from october 2001 to july 2003, 13 patients, all men, with hcc diagnosed by cytology, were transplanted at our center. locoregional therapies were percutaneous ethanol injection (pei), transcatheter hepatic arterial chemoembolization (tace), and radiofrequency microwave ablation (rfa). pei was employed in seven patients, tace in five (one of t ... | 2005 | 15866648 |
| long-term survival of a patient with advanced adenosquamous carcinoma of the gallbladder after radical resection. | patients with adenosquamous carcinoma of the gallbladder tend to present with a bulky tumor that frequently displays involvement with adjacent organs, and diagnosis is usually made at an advanced stage. this may contribute to the poor prognosis of patients with adenosquamous carcinoma of the gallbladder compared to patients with adenocarcinoma. we present herein a patient with advanced adenosquamous carcinoma of the gallbladder who is doing well with no evidence of recurrence more than 5 years a ... | 2005 | 15868080 |
| neoadjuvant therapy for rectal cancer: improved tumor response, local recurrence, and overall survival in nonanemic patients. | preoperative, long-course chemoradiotherapy is recommended for rectal cancers involving or threatening the mesorectal resection margin, but tumor response is variable. some highly radiosensitive cancers completely regress, leading to reduced local recurrence and improved survival. this study was designed to evaluate the influence of anemia during chemoradiotherapy on tumor response, local and distant recurrence, and overall survival. | 2005 | 15868236 |
| good colorectal cancer surgery. | adenocarcinoma of the colon and rectum is currently diagnosed in about 783,000 new cases annually and 437,000 patients will die of the disease each year worldwide. colorectal cancer presents as an emergency situation (obstruction, bleeding or perforation) in approximately 25% of cases and with more or less obvious chronic symptoms in the rest of cases. rectal cancer patients, with a t1 tumour can be offered local excision whereas patients with more advanced cancer must be offered a more radical ... | 2005 | 15868491 |
| [effects of fentanyl on cytokines and mda during cardiopulmonary bypass in patients undergoing valve replacement]. | to investigate the effect of fentanyl on cytokines and mda in valve replacement surgery during cardiopulmonary bypass ( cpb). | 2005 | 15871195 |
| delayed recovery of vecuronium neuromuscular block in diabetic patients during sevoflurane anesthesia. | to study recovery from vecuronium-induced neuromuscular block in diabetic patients during total iv or sevoflurane anesthesia. | 2005 | 15872123 |
| use of dna repair enzymes in electrochemical detection of damage to dna bases in vitro and in cells. | electrochemical measurements at mercury or solid amalgam electrodes offer a highly sensitive detection of dna strand breaks. on the other hand, electrochemical detection of damage to dna bases at any electrode is usually much less sensitive. in this paper, we propose a new voltammetric method for the detection of the dna base damage based on enzymatic conversion of the damaged dna bases to single-strand breaks (ssb), single-stranded (ss) dna regions, or both. supercoiled dna exposed to uv light ... | 2005 | 15859612 |
| phosphorus adsorption on natural sediments: modeling and effects of ph and sediment composition. | the classic langmuir isotherm equation was modified to describe phosphorus (p) adsorption on p-polluted sediments. the p adsorption characteristics of six sediment samples from chinese taihu lake were studied by short-term isotherm batch experiments and related to sediment composition. the maximum p adsorption capacities (pac) and p-binding energy constant (k) were obtained by nonlinearly fitting sorption data using the modified langmuir isotherm model. native adsorbed exchangeable phosphorus (n ... | 2005 | 15862324 |
| ontogeny of the thyroid hormones and cortisol in the gilthead sea bream, sparus aurata. | the aim of the study was to elucidate the pattern of changes in the whole body concentrations of thyroid hormones (th) and cortisol in eggs, pre-larvae, and larvae in the gilthead sea bream, sparus aurata. the ontogeny of these hormones was related to specific morphological characteristics that characterize early development. th and cortisol were detected in substantial amounts in the eggs of sea bream. t3 concentration in eggs was found to be higher than that of t4 (t3, 4.02+/-0.38 ng g-1; t4, ... | 2005 | 15862562 |
| acetylation of nuclear hormone receptor superfamily members: thyroid hormone causes acetylation of its own receptor by a mitogen-activated protein kinase-dependent mechanism. | because the androgen and estrogen nuclear hormone receptors are subject to acetylation, we speculated that the nuclear thyroid hormone receptor-beta1 (trbeta1), another superfamily member, was also subject to this posttranslational modification. treatment of 293t cells that contain trbeta1(wt) with l-thyroxine (t4)(10(-7)m, total concentration) resulted in the accumulation of acetylated tr in nuclear fractions at 30-45 min and a decrease in signal by 60 min. a similar time course characterized r ... | 2005 | 15862828 |
| effect of dietary carbohydrate on haematology, respiratory burst activity and histological changes in l. rohita juveniles. | a feeding trial was conducted for 60 days to delineate the effect of dietary carbohydrate on the haematology, respiratory burst activity and histology in labeo rohita juveniles. one hundred and forty four fish (av. wt. 10+/-0.15 g) were randomly distributed into 12 treatment groups with each of two replicates. twelve semi-purified diets with either 35% or 28% of crude protein were prepared with different amylase concentrations (0, 50, 100 and 150 mgkg(-1)) and starch type (gelatinised, g/non-gel ... | 2005 | 15863014 |
| influence of spine morphology on intervertebral disc loads and stresses in asymptomatic adults: implications for the ideal spine. | sagittal profiles of the spine have been hypothesized to influence spinal coupling and loads on spinal tissues. | 2005 | 15863086 |
| [intraspinal air, a rare complication of blunt chest trauma]. | pneumorachis, defined as the presence of air within the spinal canal, has rarely been described, and is exceptionally due to thoracic trauma. we report the case of a 37-year-old patient who sustained a motor vehicle accident. the chest ct-scan showed a bilateral-hemothorax, a small right pneumothorax, rib fractures, and a fracture of the fourth thoracic vertebra associated with air in the spinal canal extending from t6 to l2. the fracture of t4 associated with the pleural lesion is probably resp ... | 2005 | 15826793 |
| three prochlorococcus cyanophage genomes: signature features and ecological interpretations. | the oceanic cyanobacteria prochlorococcus are globally important, ecologically diverse primary producers. it is thought that their viruses (phages) mediate population sizes and affect the evolutionary trajectories of their hosts. here we present an analysis of genomes from three prochlorococcus phages: a podovirus and two myoviruses. the morphology, overall genome features, and gene content of these phages suggest that they are quite similar to t7-like (p-ssp7) and t4-like (p-ssm2 and p-ssm4) ph ... | 2005 | 15828858 |
| pull-out strength of the suprapedicle claw construct: a biomechanical study. | the pull-out of the superior screw is a well recognized problem in anterior instrumentation of the spine for scoliosis. a biomechanical pull-out study of anterior vertebral body screw in cadaveric thoracic spine was therefore designed to investigate and compare the pull-out strength of three different anterior vertebral body fixations using the ao universal spine system: simple bicortical screw, bicortical screw with an opposite washer (sometimes called pull-out resistant nut), and a new constru ... | 2005 | 15830212 |
| impact of colloid response on survival after preoperative radiotherapy in locally advanced rectal carcinoma. | neoadjuvant therapy for rectal carcinoma modifies morphology and natural history of the tumor. colloid response defined by predominant colloid changes with or without residual tumor cells is a form of tumor response whose impact on survival is unknown. this study evaluated influence of tumor histologic response, especially of colloid response, on survival in patients treated by long-course preoperative radiotherapy for rectal cancer. in 200 patients with ut3-t4 or n1 rectal carcinomas, influence ... | 2005 | 15832083 |
| barriers to coliphage infection of commensal intestinal flora of laboratory mice. | growth characteristics of coliphage viruses indicate that they are adapted to live with their eschericia coli hosts in the intestinal tract. however, coliphage experimentally introduced by ingestion persist only transiently if at all in the gut of humans and other animals. this study attempted to identify the barriers to long term establishment of exogenous coliphage in the gastrointestinal (gi) tracts of laboratory mice. intestinal contents were screened for the presence of coliphage and host b ... | 2005 | 15833115 |
| prognostic value of lymphovascular invasion in transitional cell carcinoma of upper urinary tract. | to elucidate the prognostic significance of lymphovascular invasion (lvi) in patients with upper tract transitional cell carcinoma. | 2005 | 15833510 |
| dysprealbuminemic hyperthyroxinemia in a patient with hyperthyroid graves disease. | rare mutant forms of circulating albumin and prealbumin [transthyretin (ttr)] have increased binding affinity for thyroxine (t4). patients with these variant plasma proteins, as a result of inherited mutations or as a paraneoplastic phenomenon, typically present with increased serum total t4 and, by some assay methodologies, an increased free t4 as well. although these individuals are, in fact, euthyroid, nonspecific symptoms may lead to inappropriate treatment for hyperthyroidism. we present a ... | 2005 | 15833783 |
| lateral vertebral assessment: a valuable technique to detect clinically significant vertebral fractures. | although many vertebral fractures are clinically silent, they are associated with increased risk for subsequent osteoporotic fractures. a substantial number of these fractures are demonstrable using instant vertebral assessment with hologic densitometers. whether similar recognition is possible using dual-energy lateral vertebral assessment (lva) with ge lunar densitometers remains uncertain. thus, we evaluated the ability of clinicians using lva to detect prevalent vertebral fractures. dual-ene ... | 2005 | 15834512 |
| the body mass index and level of resection: predictive factors for compensatory sweating after sympathectomy. | compensatory sweating (cs) is the most common adverse event and the main cause of dissatisfaction among patients undergoing a vats sympathectomy for the treatment of primary hyperhidrosis. it has been described that obese individuals experience more sweating than thinner ones. the aim of this study is to identify the body mass index (bmi) and the level of resection as predictive factors for cs and its relation to levels of patient satisfaction following the procedure. | 2005 | 15834768 |
| telomerase activity in urine sediments as a tool for noninvasive detection of bladder cancer. | telomerase is extensively investigated as potential diagnostic and prognostic marker in human tumors. in this study, we determined telomerase activity in histological specimens and voided urine of 52 human bladder cancers. using the pcr-elisa method telomerase activity was found in 21 (88%) of the 24 tumor tissues and in the corresponding sediments from voided urine of patients with superficial bladder carcinoma (ta/t1). in case of muscle-invasive tumors (t2-t4), telomerase activity was found in ... | 2005 | 15837544 |
| the genome of s-pm2, a "photosynthetic" t4-type bacteriophage that infects marine synechococcus strains. | bacteriophage s-pm2 infects several strains of the abundant and ecologically important marine cyanobacterium synechococcus. a large lytic phage with an isometric icosahedral head, s-pm2 has a contractile tail and by this criterion is classified as a myovirus (1). the linear, circularly permuted, 196,280-bp double-stranded dna genome of s-pm2 contains 37.8% g+c residues. it encodes 239 open reading frames (orfs) and 25 trnas. of these orfs, 19 appear to encode proteins associated with the cell en ... | 2005 | 15838046 |
| common viral infection affects pentabrominated diphenyl ether (pbde) distribution and metabolic and hormonal activities in mice. | a murine model infection with the human coxsackievirus b3 (cb3) has been shown to change uptake and tissue distribution of several environmental pollutants, in some cases followed by an aggravated disease. in this study, the model was tested for polybrominated diphenyl ethers (pbdes), which we know are absorbed from the gastro-intestinal tract and further distributed throughout the body. on day 0, female balb/c mice were infected with cb3; on day 1 of the infection, they were dosed orally with a ... | 2005 | 15840429 |
| salt dependent binding of t4 gene 32 protein to single and double-stranded dna: single molecule force spectroscopy measurements. | bacteriophage t4 gene 32 protein (gp32) is a well-studied representative of the large family of single-stranded dna (ssdna) binding proteins, which are essential for dna replication, recombination and repair. surprisingly, gp32 has not previously been observed to melt natural dsdna. at the same time, *i, a truncated version of gp32 lacking its c-terminal domain (ctd), was shown to decrease the melting temperature of natural dna by about 50 deg. c. this profound difference in the duplex destabili ... | 2005 | 15890198 |
| comparison of effects of methylprednisolone and anti-cd11d antibody treatments on autonomic dysreflexia after spinal cord injury. | autonomic dysreflexia is a condition of episodic hypertension that develops after spinal cord injury (sci). we previously showed that a two-day anti-inflammatory treatment with an anti-cd11d integrin monoclonal antibody (mab), soon after sci in rats, reduced the magnitude of dysreflexia for at least 6 weeks. effects of methylprednisolone (mp), a commonly used neuroprotective treatment for sci, on dysreflexia have never been examined. we compared the effects of a 2-day mp treatment and/or the ant ... | 2005 | 15890340 |
| l-thyroxine activates akt signaling in the heart. | hyperthyroidism causes physiological cardiac hypertrophy and enhanced function. many of these effects have been traditionally attributed to changes in gene expression. however, the role of signal transduction pathways in the effects mediated by thyroid hormone (th) have recently gained a significant amount of attention in non-cardiovascular cells and tissue. whether signal transduction pathways are involved in the cardiac effects of th is unknown. in this study, we treated sprague dawley rats wi ... | 2005 | 15890358 |
| thyroid hormone availability and activity in avian species: a review. | the intracellular thyroid hormone (th) availability is influenced by different metabolic pathways. some of the changes in intracellular th availability can be linked to changes in local deiodination and sulfation capacities. the secretion of the chicken thyroid consists predominantly of thyroxine (t4). th receptors (trs) preferentially bind 3,5,3'-triiodothyronine (t3). therefore, the metabolism of t4 secreted by the thyroid gland in peripheral tissues, resulting in the production and degradatio ... | 2005 | 15890488 |
| the activities of antioxidant enzymes and monoamine oxidase and uncoupling protein 1 content in brown fat of hypo- and hyperthyroid rats. | we have studied the activities of antioxidant enzymes (aoe), namely, copper-zinc superoxide dismutase (cuznsod), manganese superoxide dismutase (mnsod), and catalase (cat), and the activity of catecholamine-degrading enzyme monoamine oxidase (mao) and uncoupling protein 1 (ucp1) content in brown fat (bf) of hypo- and hyperthyroid rats. we found that hypothyroidism decreased bf ucp1 content and increased mao, mnsod, and cat activities. t3 increased ucp1 content and mnsod activity and decreased cu ... | 2005 | 15891081 |
| evolution of the thyroid hormone distributor protein transthyretin in microbes, c. elegans, and vertebrates. | transthyretin (ttr) is an extracellular thyroid hormone distributor protein in vertebrates, whose structure has been highly conserved between fish and humans. however, the ligand preferentially bound by ttr has changed during evolution from 3',3,5-l-triiodothyronine (t3) to 3',5',3,5-l-tetraiodothyronine (t4). we identified genes in the genomes of >50 species of nonvertebrates, which could code for ttr-like proteins. molecular modeling suggested most would have similar 3d structures and electros ... | 2005 | 15891085 |
| effects of acute organophosphate poisoning on thyroid hormones in rats. | the aim of this study was to investigate the effects of organophosphate poisoning on thyroid hormones. in this study, male wistar albino rats weighing 200-225 g were used. the rats were divided into 4 groups. group 1 (n = 10) was administered 30 mg/kg lethal dose of methamidophos, whereas group 2 (n = 7) was treated with physiologic nacl (sp). group 3 (n = 10) was treated with 30 mg/kg of methamidophos. when cholinergic symptoms developed among the rats in group 3, they were treated with 40 mg/k ... | 2005 | 15891268 |
| [subacute meningoradiculomyeloencephalitis due to cryptococcosis infection]. | if meningoencephalitis with or without mass lesion (granuloma or abscess) is the most common pattern of cns cryptococcal infection, intramedullary involvement is very uncommon. | 2005 | 15893031 |
| comparison of neoadjuvant cisplatin-based chemotherapy versus radiochemotherapy followed by resection for stage iii (n2) nsclc. | comparison of prospectively treated patients with neoadjuvant cisplatin-based chemotherapy vs radiochemotherapy followed by resection for mediastinoscopically proven stage iii n2 non-small cell lung cancer with respect to postoperative morbidity, pathological nodal downstaging, overall and disease-free survival, and site of recurrence. | 2005 | 15896624 |
| prognostic significance of microvascularization in cases of operated lung cancer. | measurement of microvascularization and determination of its prognostic significance in cases of lung cancer. | 2005 | 15896626 |
| the oligomeric t4 primase is the functional form during replication. | replisome dna primases are responsible for the synthesis of short rna primers required for the initiation of repetitive okazaki fragment synthesis on the lagging strand during dna replication. in bacteriophage t4, the primase (gp61) interacts with the helicase (gp41) to form the primosome complex, an interaction that greatly stimulates the priming activity of gp61. because gp41 is hexameric, a question arises as to whether gp61 also forms a hexameric structure during replication. several results ... | 2005 | 15897200 |
| critical appraisal of the clinical and pathologic predictors of survival after resection of large hepatocellular carcinoma. | a subset of patients with hepatocellular carcinoma (hcc) with a diameter of 10 cm or larger may benefit from hepatic resection. | 2005 | 15897440 |
| the effect of low-flow sevoflurane and desflurane on pulmonary mechanics during laparoscopic surgery. | this study was designed to investigate the effects of inhaled anesthetic agents on respiratory mechanics with low flow anesthesia in laparoscopic abdominal surgery. two inhaled anesthetics, desflurane and sevoflurane, have a lower solubility in blood and tissues than all previous volatile anesthetics, and have become the preferred volatile anesthetics for routine surgical procedures. | 2005 | 15898901 |
| diagnosis of the depth of invasion of esophageal carcinoma using digital radiography. | the purpose of our investigation was to determine the usefulness of digital radiography (dr) for diagnosing the depth of invasion of esophageal carcinoma. | 2005 | 15899339 |
| clinical and immunohistologic typing of salivary duct carcinoma: a report of 50 cases. | due to the low incidence of salivary duct carcinoma (sdc), only limited data in regard to the biologic behavior of this tumor and its immunohistochemical characteristics are available. the authors analyzed the clinical, molecular, and genetic profile of sdc and identified prognostic factors. | 2005 | 15900577 |
| tumour staging using magnetic resonance imaging in clinically localised prostate cancer: relationship to biochemical outcome after neo-adjuvant androgen deprivation and radical radiotherapy. | to evaluate the prognostic significance of magnetic resonance imaging (mri) tumour stage in clinically localised prostate cancer. | 2005 | 15901000 |
| nad+-dependent dna ligase (rv3014c) from mycobacterium tuberculosis. crystal structure of the adenylation domain and identification of novel inhibitors. | dna ligases utilize either atp or nad+ as cofactors to catalyze the formation of phosphodiester bonds in nicked dna. those utilizing nad+ are attractive drug targets because of the unique cofactor requirement for ligase activity. we report here the crystal structure of the adenylation domain of the mycobacterium tuberculosis nad+-dependent ligase with bound amp. the adenosine nucleoside moiety of amp adopts a syn-conformation. the structure also captures a new spatial disposition between the two ... | 2005 | 15901723 |
| [an observation on long-term results of subtotal laryngectomy with preservation of an arytenoid cartilage]. | to discuss the long-term results of the subtotal laryngectomy with preservation of an arytenoids cartilage. | 2005 | 15906521 |
| association of the risk of development of hypothyroidism after iodine 131 treatment with the pretreatment pattern of sodium pertechnetate tc 99m uptake in the thyroid gland in cats with hyperthyroidism: 165 cases (1990-2002). | to assess whether the risk of development of hypothyroidism after treatment with iodine 131 (131i) was associated with the pattern of sodium pertechnetate tc 99m activity in the thyroid gland detected via scintigraphy before treatment in cats with hyperthyroidism. | 2005 | 15906566 |
| the non-thyroidal illness syndrome after coronary artery bypass grafting: a 6-month follow-up study. | the non-thyroidal illness syndrome (ntis) is considered a transient and completely reversible phenomenon, but it has been shown that it may last for several days postoperatively after coronary artery bypass grafting (cabg) surgery. this study was undertaken to assess thyroid function 6 months after uncomplicated cabg. the thyroid profile was evaluated in 40 consecutive patients undergoing cabg preoperatively, at 0, 12, 48, and 120 h postoperatively, and at 6-month follow-up. triiodothyronine (t3 ... | 2005 | 15843233 |
| extended multiorgan resection for t4 gastric carcinoma: 25-year experience. | in locally advanced gastric carcinoma infiltrating adjacent organs, an extended resection including invaded organs is required to improve the prognosis. we retrospectively analyzed our experience with extended multiorgan resection (emr) in patients with advanced gastric cancer. | 2005 | 15844189 |
| cluster formation by allelomimesis in real-world complex adaptive systems. | animal and human clusters are complex adaptive systems and many organize in cluster sizes s that obey the frequency distribution d (s) proportional to s(-tau). the exponent tau describes the relative abundance of the cluster sizes in a given system. data analyses reveal that real-world clusters exhibit a broad spectrum of tau values, 0.7 (tuna fish schools) <or=tau<or=4.61 (t4 bacteriophage gene family sizes). allelomimesis is proposed as an underlying mechanism for adaptation that explains the ... | 2005 | 15903699 |
| promising results of a cooperative group phase ii trial of preoperative chemoradiation for locally advanced rectal cancer (trog 9801). | this article reports the overall survival, failure-free survival, local failure, and late radiation toxicity of a phase ii trial of preoperative radiotherapy with continuous infusion 5-fluorouracil for rectal cancer after a minimum 3.5 years of follow-up. | 2005 | 15906126 |
| prospective non-randomized trial comparing esophagectomy-followed-by-chemoradiotherapy versus chemoradiotherapy-followed-by-esophagectomy for t4 esophageal cancers. | multimodal treatment is commonly adopted for patients with a t4 esophageal cancer. this trial evaluated which therapy offered a better survival: preoperative chemoradiotherapy (crt) or postoperative crt. | 2005 | 15906363 |
| action of human endonucleases iii and viii upon dna-containing tandem dihydrouracil. | we have shown previously that endonuclease iii from escherichia coli, its yeast homolog ntg1p and e. coli endonuclease viii recognize single dihydrouracil (dhu) lesions efficiently. however, these enzymes have limited capacities for completely removing dhu, when the lesion is present on duplex dna as a tandem lesion. a duplex 30-mer (duplex1920) containing tandem dhu lesions at positions 19 and 20 from the 5' terminus was used as a substrate for human endonuclease iii (hnth) and endonuclease vii ... | 2005 | 15907775 |
| parotid gland-sparing 3-dimensional conformal radiotherapy results in less severe dry mouth in nasopharyngeal cancer patients: a dosimetric and clinical comparison with conventional radiotherapy. | this study examined the efficacy of parotid gland sparing of three-dimensional conformal radiotherapy (3dcrt) compared with conventional radiotherapy for npc patients. both the dose given to the parotids and clinical assessment of dry mouth were conducted. | 2005 | 15908027 |
| target search of n sliding proteins on a dna. | at low to moderate ambient salt concentrations, dna-binding proteins bind relatively tightly to dna, and only very rarely detach. intersegmental transfer due to dna-looping can be excluded by applying an external pulling force to the dna molecule. under such conditions, we explore the targeting dynamics of n proteins sliding diffusively along dna in search of their specific target sequence. at lower densities of binding proteins, we find a reduction of the characteristic search time proportional ... | 2005 | 15908574 |
| interaction between the t4 helicase loading protein (gp59) and the dna polymerase (gp43): unlocking of the gp59-gp43-dna complex to initiate assembly of a fully functional replisome. | single-molecule fluorescence resonance energy transfer and functional assays have been used to study the initiation and regulation of the bacteriophage t4 dna replication system. previous work has demonstrated that a complex of the helicase loading protein (gp59) and the dna polymerase (gp43) on forked dna totally inhibits the polymerase and exonuclease activities of gp43 by a molecular locking mechanism (xi, j., zhuang, z., zhang, z., selzer, t., spiering, m. m., hammes, g. g., and benkovic, s. ... | 2005 | 15909989 |
| templated metal catalysis for single nucleotide specific dna sequence detection. | a catalytic dna-templated reaction of hydrolysis of an ester group in an n-modified peptide nucleic acid, which is activated by a cu2+ complex-pna, has been discovered and optimized. both the ester-containing pna and the metal complex pna bind neighboring sites on a template dna. this brings the reacting groups (the ester and the cu2+ complex) in proximity to each other and accelerates the hydrolysis of the ester approximately 500 times in comparison with its hydrolysis in the absence of the tem ... | 2005 | 15913375 |
| dna repair in a protein-dna complex: searching for the key to get in. | an obstacle encountered by nucleotide excision repair (ner) proteins during repair of the genome is the masking of bulky lesions by dna binding proteins. for example, certain transcription factors are known to be impediments, and suppress damage removal at their recognition sequences. we have used well-defined protein-dna complexes to study the molecular mechanism(s) used by repair proteins in gaining access to dna lesions in chromatin. using transcription factor iiia (tfiiia) and the 5s ribosom ... | 2005 | 15913668 |
| combination of his-tagged t4 endonuclease vii with microplate array diagonal gel electrophoresis for high-throughput mutation scanning. | 2005 | 15914792 |