Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| gastric interleukin-8 and iga il-8 autoantibodies in helicobacter pylori infection. | gastric infection with helicobacter pylori is frequently characterized by neutrophil infiltration. the production of the neutrophil-activating peptide (nap-1/il-8) and mucosal iga autoantibodies to il-8 by human antral biopsies have been examined during short-term in vitro culture. detectable il-8 was secreted by 84% of h. pylori-negative patients with normal antral mucosa (range < 0.07-61.5 ng/mg biopsy protein, n = 19). concentrations in 4 patients with reactive gastritis and 10 with inactive ... | 1993 | 8418474 |
| the helicobacter pylori 19.6-kilodalton protein is an iron-containing protein resembling ferritin. | the gastric pathogen helicobacter pylori has been shown to produce a 19.6-kda protein with apparent binding activity for erythrocytes, human buccal epithelial cells, and laminin. in this report we demonstrate that it is an iron-binding protein, resembling ferritin both structurally and biochemically. also, because its binding activity for laminin, erythrocytes, and buccal cells was abolished by low concentrations of tween 20, binding is likely nonspecific. | 1993 | 8419304 |
| effect of ranitidine and amoxicillin plus metronidazole on the eradication of helicobacter pylori and the recurrence of duodenal ulcer. | persistent infection with helicobacter pylori is associated with the recurrence of duodenal ulcer. whether the efficacy of bismuth therapy in reducing the rate of recurrence of duodenal ulcer is due to its antimicrobial effects on h. pylori or to a direct protective action on the mucosa is still a matter of debate. | 1993 | 8419816 |
| treatment of peptic ulcers caused by helicobacter pylori. | 1993 | 8419823 | |
| helicobacter pylori antibodies in areas of italy at varying gastric cancer risk. | in a survey of 930 adults aged 35-74 years randomly sampled from the general population of four areas of italy, two at low and two at high risk for gastric cancer, plasma levels of helicobacter pylori igg antibodies were assayed in order to investigate associations with the geographical distribution of gastric cancer and other dietary and life-style factors, as assessed by personal interview. h. pylori positivity (antibody titer above or equal to 10 micrograms/ml), 45% overall, increased with ag ... | 1993 | 8420610 |
| link between helicobacter pylori-associated gastritis and duodenal ulcer. | we examined the interrelationships among the degree of fundic mucosal atrophy, the prevalence of helicobacter pylori in the gastric antrum, the gastric juice, and the duodenum with and without gastric metaplasia, in 20 duodenal ulcer patients and 20 non-duodenal ulcer patients. the detection rates of h. pylori in the antrum, the gastric juice, and the duodenum were significantly higher in duodenal ulcer patients (80%, 65%, and 60%) than in non-duodenal ulcer subjects (50%, 20%, and 5%). the freq ... | 1993 | 8420742 |
| helicobacter pylori increases gastric antral juxtamucosal ph. | in order to examine the effect of helicobacter pylori colonization on the gastric mucus microclimate, antral juxtamucosal ph was measured in 47 patients attending as out patients for upper gastrointestinal endoscopy. the mean ph in 28 patients negative for h. pylori was 6.40 +/- 0.24 compared to 6.88 +/- 0.16 in 19 patients who were positive (p < 0.0001). in six of seven patients who agreed to a second study, h. pylori was eradicated and the mean ph fell from 6.81 +/- 0.17 to 6.08 +/- 0.16 (p < ... | 1993 | 8420744 |
| helicobacter pylori in duodenal ulcer patients with idiopathic gastric acid hypersecretion. | thirty-three consecutive patients with idiopathic gastric acid hypersecretion (defined as a basal acid output > 10.0 meq/hr with a normal fasting serum gastrin level and negative secretin stimulation test) who were being treated for duodenal ulcer disease and other acid-peptic disorders were evaluated for the presence of helicobacter pylori by means of a rapid urease test. fourteen patients had duodenal ulcer and 19 had other acid-peptic disorders (gastroesophageal reflux in 14, including six wi ... | 1993 | 8420745 |
| a neutrophil chemotactic factor present in h. pylori but absent in h. mustelae. | this study was designed to compare the capabilities of helicobacter pylori and helicobacter mustelae to generate neutrophil chemotactic activity (nca) in vitro. h. pylori and h. mustelae were grown in parallel cultures under identical conditions. the cultures were washed and transferred to saline solution for 3 hr to avoid detecting nonspecific chemotactic activity from culture media. supernatants were subjected to size-exclusion hplc. all peaks from hplc were collected and assayed for nca. peak ... | 1993 | 8420746 |
| study of helicobacter pylori colonization of patches of heterotopic gastric mucosa (hgm) at the upper esophagus. | helicobacter pylori (hp), known to cause active chronic gastritis, has primarily been found in gastric-type mucosa. even in the duodenum, the organism was detected in islands of metaplastic gastric mucosa. hp has also been found in gastric metaplasia of barrett's esophagus in 15-50%. the aim of our study was to determine: (1) the frequency with which hp is found on histopathological sections of heterotopic gastric mucosa (hgm) patch(es) at the upper esophagus, as compared to that of the stomach ... | 1993 | 8420747 |
| helicobacter pylori and gastroduodenal disorders in india--lessons from epidemiology. | the relationship of helicobacter pylori and gastroduodenal disorders should be compared in the developing (dg) and developed (dd) nations (table 1) for a better understanding of the etiopathogenesis of these disorders. although chronic gastritis is widespread in the dg nations, benign and malignant gastric ulcer (gu) are uncommon. repeated reinfections and longer duration of h. pylori infection in the fundus-body mucosa of patients with duodenal ulcer from the dg nations explain the lower values ... | 1993 | 8421150 |
| the 13c-urea breath test, helicobacter pylori infection, and the operated stomach. | 1993 | 8421157 | |
| the association of helicobacter pylori with gastric cancer and preneoplastic gastric lesions in chiapas, mexico. | helicobacter pylori recently was identified as a risk factor for gastric cancer. its association with preneoplastic conditions of the stomach, however, is undocumented. | 1993 | 8422620 |
| demonstration of helicobacter pylori in tracheal secretions. | a new gram-negative bacterium, helicobacter pylori, has been found in gastric secretions. in view of an almost 9% incidence of unidentified gram-negative bacteria in aspiration pneumonia, the authors set out to prove that h pylori could be found in tracheal secretions. eighteen sequential patients admitted to the intensive care unit who had endotracheal or nasogastric intubation for 24 hours or longer were studied. of 20 sets of specimens from 18 patients. helicobacter was recovered from 2(10%) ... | 1993 | 8423130 |
| metronidazole-resistant helicobacter pylori in a developing country. | 1993 | 8424447 | |
| glucose phosphorylation in helicobacter pylori. | saccharide kinase activities in helicobacter pylori were investigated by incubating bacterial lysates with atp and mono- or disaccharides and monitoring directly the appearance of phosphorylated products using 13c or 31p nuclear magnetic resonance spectroscopy. the monosaccharides employed included two trioses, two tetroaldoses, one tetroketose, five aldopentoses, two ketopentoses, five aldohexoses, three ketohexoses, and gluconic and glucuronic acids; the disaccharides studied were maltose, tre ... | 1993 | 8424689 |
| [helicobacter detected in children of helicobacter pylori-positive parents]. | the authors examined 48 children of helicobacter pylori positive parents: 52% were serologically positive for helicobacter pylori using the orion diagnostics pyloriset latex agglutination test. of these children 10 had upper abdominal pain, heartburn and acid eructation and osesophagogastroscopy was performed; seven were found to be helicobacter pylori positive histologically. these results draw attention to the transmission of helicobacter pylori infection within families. they suggest that the ... | 1993 | 8426729 |
| helicobacter pylori and peptic ulcer disease. | the role played by helicobacter pylori in the pathogenesis of peptic ulcer disease (pud) is discussed, and the epidemiology, identification, diagnosis, eradication, and treatment of h. pylori infection are reviewed. isolation of h. pylori from up to 100% of patients with duodenal ulcer and 80% of patients with gastric ulcer establishes a strong association between h. pylori and idiopathic pud, although other factors also may be essential for the development of pud. invasive procedures for diagno ... | 1993 | 8428432 |
| [peptic ulcer and helicobacter pylori. comments on the authors' cases]. | the presence of helicobacter was tested on a group with antral or duodenal ulcer with or without gastritis, versus a group without gastric or duodenal pathology. furthermore an open trial was performed between omeprazole and colloidal bismuth subcitrate (cbs) on patients similarly affected by peptic disease. although cbs did eliminate helicobacter in more than a half of patients, what was not obtained by omeprazole, this result did not mean a better control of peptic disease: in fact the omepraz ... | 1993 | 8430247 |
| [the effect of colloidal bismuth and its combination with amoxicillin on the elimination of helicobacter pylori in patients with a duodenal ulcer and chronic antral gastritis]. | although the aetiopathogenetic role of helicobacter pylori (hp) in duodenal ulcer and in chronic gastritis seems now well defined, we have not yet standardized therapeutic schedules to achieve disappearance of hp. this study was aimed at evaluating the efficacy of two different therapeutic schedules, colloidal bismuth alone [cb(1200 mg/day)], vs. association with amoxicillin [cb+a(3 g/day)] for six weeks, to clear hp from antral specimens in a cohort of dyspeptic patients. 49 consecutive patient ... | 1993 | 8430249 |
| transformation of helicobacter pylori by electroporation. | a highly efficient method of introducing dna into an important human pathogen is reported here. electroporation-mediated transformation of a laboratory-passaged isolate of helicobacter pylori was successfully used to establish genetic mutants at a transformation frequency of > 10(5)/micrograms dna. this method should be widely applicable to all isolates of h. pylori and may eliminate the variability reported when natural transformation was used on fresh clinical isolates. | 1993 | 8431287 |
| experimental gastritis induced by helicobacter pylori in japanese monkeys. | we used japanese monkeys (macaca fuscata) to establish an experimental model in order to clarify the pathogenicity of helicobacter pylori in gastric and duodenal disorders. a suspension (5 ml; 10(9) cfu/ml) of h. pylori cells isolated from humans was sprayed around the antrum of the stomach of each of 12 of 17 animals with an endoscope. the remaining five animals were not inoculated; they served as a control group. on days 7, 14, and 28 after inoculation, the gastric mucosa samples were examined ... | 1993 | 8432614 |
| paracrystalline inclusions of a novel ferritin containing nonheme iron, produced by the human gastric pathogen helicobacter pylori: evidence for a third class of ferritins. | an abundant 19.3-kda helicobacter pylori protein has been cloned, and the sequence is homologous with a ferritin-like protein produced by escherichia coli k-12. homologies are also present with a number of eucaryotic ferritins, as well as with the heme group-containing bacterioferritins. all amino acids involved in chelation of inorganic iron by ferritins from humans and other higher species are conserved in the h. pylori protein. consistent with the structural data indicating an iron-binding fu ... | 1993 | 8432720 |
| ammonium metabolism and protection from urease mediated destruction in helicobacter pylori infection. | to investigate further the intracellular ammonium metabolism of helicobacter pylori and the mechanism of its urease mediated destruction. | 1993 | 8432895 |
| high gastric juice ascorbic acid concentrations in members of a gastric cancer family. | gastric juice ascorbic acid, total vitamin c, nitrite and n-nitroso-compound concentrations were determined in fasting gastric juice from four second generation members of a gastric cancer family, all of whom had helicobacter pylori-associated chronic gastritis and intestinal metaplasia. juice ph, nitrite and n-nitroso-compound concentrations were low. juice ascorbate levels were comparable to those found in subjects with normal histology. the findings are contrary to our previous experience wit ... | 1993 | 8435869 |
| [is helicobacter pylori gastritis a macroscopic diagnosis?]. | in a prospective study, gastroscopy and biopsies from the gastric antrum and body were undertaken in 100 consecutive patients (67 women, 33 men; mean age 58.6 [11-90] years) with unknown helicobacter pylori status. none had been on any bacteria-suppressing drugs. main indications for gastroscopy were upper abdominal pain, dyspepsia, emesis and anaemia of unknown cause. the macroscopic criteria for the diagnosis of h. pylori gastritis were the presence of at least one of the following signs: (1) ... | 1993 | 8436066 |
| pathology of the gastric antrum and body associated with helicobacter pylori infection in non-ulcerous patients: is the bacterium a promoter of intestinal metaplasia? | a series of 115 consecutive, non-ulcerous, dyspeptic patients were examined for helicobacter pylori (h. pylori) colonization in the gastric antral and/or body mucosa using giemsa staining. findings were correlated with the presence and degree of activity of superficial gastritis, deep gastritis, atrophic gastritis and with the presence of intestinal metaplasia. the prevalence of h. pylori positivity was 61.7%. in 59 of the 71 positive patients (83%), h. pylori was detected in the antrum or in bo ... | 1993 | 8436350 |
| [10 years helicobacter (campylobacter) pylori]. | 1993 | 8438600 | |
| pathological case of the month. helicobacter pylori gastritis. | 1993 | 8438818 | |
| relationship between helicobacter pylori colonization and acute inflammation of the duodenal mucosa. | a relationship between helicobacter pylori colonization and acute inflammation of the duodenal mucosa was studied in 75 patients with duodenal ulcer and nine with endoscopically normal duodenal mucosa. a biopsy of the duodenal bulb in each patient was used for both detection of h. pylori and histological assessment of acute inflammation [polymorphonuclear leukocyte (pmn) infiltration and regenerative changes of the duodenal epithelial cells]. biopsies with regenerative changes showed a marked pm ... | 1993 | 8438841 |
| gastrointestinal motility in patients with non-ulcer dyspepsia: a role for helicobacter pylori infection? | motor disorders of the upper gastrointestinal tract are a frequent finding in patients with non-ulcer dyspepsia (nud). in this study we attempted to assess whether helicobacter pylori infection contributes to gastrointestinal motor disorders in nud. interdigestive and post-prandial gastrointestinal motility was studied in 46 consecutive patients with nud and in eight healthy control subjects. abdominal complaints were assessed by means of a symptom score. chronic gastritis and h. pylori infectio ... | 1993 | 8438842 |
| eradication of helicobacter pylori normalizes serum gastrin concentration and antral gastrin cell number in a patient with primary gastrin cell hyperplasia. | a 60-yr-old man with longstanding duodenal ulcer was found to have hyperchlorhydria, moderate fasting hypergastrinemia, and markedly exaggerated meal-stimulated gastrin release. antral tissue specimens showed the proliferation of gastrin cells and increased gastrin content, and he was found to have helicobacter pylori infection in the antral mucosa. his illness was diagnosed as primary gastrin cell hyperplasia with h. pylori infection. eradication of h. pylori normalized not only gastrin hyperse ... | 1993 | 8438856 |
| short report: a non-metronidazole triple therapy for eradication of helicobacter pylori infection--tetracycline, amoxicillin, bismuth. | triple therapies using bismuth, metronidazole and tetracycline or amoxicillin were the first truly successful anti-h. pylori therapies. metronidazole resistance has become an increasing problem that has severely limited the usefulness of the original triple therapy. resistance to tetracycline or amoxicillin has not been reported and both are effective against h. pylori. we therefore tested a new triple therapy consisting of 500 mg tetracycline, 500 mg amoxicillin, and 2 tablets of bismuth subsal ... | 1993 | 8439632 |
| gastric and duodenal mucosal blood flow in patients receiving non-steroidal anti-inflammatory drugs--influence of age, smoking, ulceration and helicobacter pylori. | using laser doppler flowmetry, we measured gastric and duodenal mucosal blood flow in 70 patients who had taken non-steroidal anti-inflammatory drugs (nsaids) for longer than 4 weeks, and studied the correlation with demographic factors, ulceration, and helicobacter pylori. blood flow was also measured in 17 other subjects not taking any drugs. measurements were taken from healthy-looking mucosa in the gastric antrum and the first part of the duodenum. both gastric and duodenal blood flow values ... | 1993 | 8439636 |
| cell kinetics of mucosal atrophy in rat stomach induced by long-term administration of ammonia. | helicobacter pylori produces ammonia in the stomach from urea. the present study was undertaken to clarify whether ammonia has an etiological role in h. pylori-associated gastric mucosal atrophy. | 1993 | 8440436 |
| ethnic differences in helicobacter pylori infection. | 1993 | 8444233 | |
| the e test for antimicrobial susceptibility testing of helicobacter pylori. | antimicrobial susceptibility testing of helicobacter pylori by conventional means (disc diffusion) is of questionable value because the bacterium grows so slowly. we have determined the susceptibilities of 20 isolates of h. pylori to ampicillin, erythromycin, gentamicin, metronidazole, rifampicin and tetracycline by the e test, a novel technique for measuring mics, and compared the results with those determined by standard agar dilution and disc diffusion methods. eighty-one per cent of e test-d ... | 1993 | 8444676 |
| bafilomycin a1 inhibits helicobacter pylori-induced vacuolization of hela cells. | bafilomycin a1, a specific inhibitor of the vacuolar-type h(+)-atpase, responsible for acidification of intracellular compartments, prevents the vacuolization of hela cells induced by h. pylori, with an inhibitory concentration giving 50% of maximal (id50) of 4 nm. bafilomycin a1 is also very efficient in restoring vacuolated cells to a normal appearance. the vacuolating activity of helicobacter pylori is not inhibited by a series of specific inhibitors of vacuolar h(+)-atpases. these findings i ... | 1993 | 8446034 |
| the role of helicobacter pylori in non-ulcer dyspepsia and gastritis. | a review is presented on the relationship between helicobacter pylori infection and gastritis and its possible significance in non-ulcer dyspepsia. although there is consensus about the pathogenetic role of h. pylori in gastritis, the correlation between h. pylori and gastritis does not appear to be qualitative, as generally thought and accepted, but rather quantitative. it is not a black and white relationship; in other words the microorganism is present in large quantities in inflamed tissue b ... | 1993 | 8446230 |
| cigarette smoking and helicobacter pylori infection. | the direct urease test was used in 462 patients with normal upper digestive tracts, 108 with duodenal ulcers and 43 with gastric ulcers who attended for upper digestive endoscopy in a prospective study. there was a strong association between helicobacter pylori infection and current cigarette smoking in patients with normal endoscopy (49.6% vs 35.5%, p < 0.01). the associations of peptic ulcer both with h. pylori infection and cigarette smoking were also confirmed. the excess of peptic ulcer dis ... | 1993 | 8446549 |
| increased prevalence of helicobacter pylori antibodies among nurses. | numerous studies have suggested that helicobacter pylori infection in asymptomatic subjects is transmitted from person to person. its prevalence is higher in the institutionalized setting. if that is the case, persons involved in patient care should have a higher prevalence of the infection. | 1993 | 8447708 |
| background and historical considerations of helicobacter pylori. | 1993 | 8449559 | |
| diagnosis of helicobacter pylori infection. | in conclusion, h. pylori infection can be detected by a variety of methods. the simplest, least expensive noninvasive method is serologic testing. unfortunately, positive serology can only presume current infection. urea breath testing is also noninvasive and is positive only in the setting of current infection; it is more expensive than serology and results in low-level radiation exposure when 14c urea is used. endoscopy with biopsy is invasive and relatively expensive; however, it is readily a ... | 1993 | 8449560 |
| helicobacter pylori, gastric ulcer, and agents noxious to the gastric mucosa. | conclusions regarding the interaction of h. pylori infection with noxious agents such as nsaids, alcohol, and smoking in the development of histologic gastritis and gross gastric injury are limited by the paucity of well-performed studies specifically addressing this problem. at present, we can conclude that h. pylori prevalence is not affected by nsaids, alcohol, or smoking. on the other hand, reflux of duodenal contents may play a role in eradication of h. pylori after gastroenterostomy. altho ... | 1993 | 8449561 |
| helicobacter pylori infection and duodenal ulcer disease. | h. pylori is undoubtedly the dominant factor in the multifactorial peptic ulcer diathesis. we should not ignore the other contributing factors but rather try to identify how they interact with the organism and initiate the ulcerative process. the interplay of acid attack and mucosal defence is modulated by genetics, gender, blood group, smoking, age, and various physiologic considerations, which include acid output. these and other considerations probably explain the discrepancy between the high ... | 1993 | 8449562 |
| the role of helicobacter pylori in nonulcer dyspepsia. a debate--for. | nonulcer (functional) dyspepsia is a common heterogenous disease resulting in upper gastrointestinal tract symptoms. evidence would support that a subset of this disease is caused by h. pylori-induced gastritis. despite the conflicting evidence, most studies evaluating h. pylori clearance and eradication, particularly the long-term studies, have observed clinical improvement in most subjects. hill's concepts to distinguish causal from noncausal associations of an agent to a specific disease incl ... | 1993 | 8449563 |
| the role of helicobacter pylori in nonulcer dyspepsia. a debate--against. | approximately 50% of patients with nonulcer dyspepsia harbor helicobacter pylori gastritis, yet there is no convincing evidence that h. pylori is causally linked to chronic dyspepsia. the prevalence of h. pylori is probably not higher in patients with nonulcer dyspepsia than in the asymptomatic general population, and h. pylori is not associated with a specific symptom profile. moreover, no plausible mechanisms to explain how histologic gastritis could induce intermittent symptoms have been iden ... | 1993 | 8449564 |
| helicobacter pylori in the pediatric patient. | h. pylori is the major cause of gastritis in children and adults. studies in children have demonstrated a specific association between h. pylori and primary gastritis. h. pylori colonization of the gastric mucosa is also important in relation to the natural history of duodenal ulcer disease. duodenal ulcers do not appear to relapse if h. pylori is cleared from the gastric mucosa. because of the low incidence of duodenal ulcer disease in children, a multicenter study is required to demonstrate wh ... | 1993 | 8449565 |
| treatment strategies for helicobacter pylori infection. | helicobacter pylori can be eradicated easily in most patients with a 14-day triple-therapy regimen. in patients in whom this treatment fails or who cannot take a full course, other antimicrobial combinations must be considered. this article discusses the various alternatives and explains why various agents should or should not be used. it also includes many new therapies developed in 1992 that allow the physician to treat virtually all h. pylori infections. | 1993 | 8449566 |
| common-sense management of helicobacter pylori-associated gastroduodenal disease. personal views. | we have tried to present a rational approach to the medical treatment of peptic ulcer disease and nonulcer dyspepsia in the era of h. pylori. we are aware that the natural history of peptic ulcer disease is still debated. some clinicians believe that peptic ulcer disease may "burn out" over a 10- to 15-year period, and in light of this, the emphasis toward a nonsurgical "cure" for peptic ulcer disease may seem misguided. yet, all factors must be taken into account. current medical therapy has de ... | 1993 | 8449567 |
| gastric bacteria other than helicobacter pylori. | since the culture of helicobacter pylori from the human stomach in 1983 there has been renewed interest in other bacteria that had been observed in animal stomachs as early as late in the nineteenth century. many of these bacteria have now been isolated and have been shown to belong to the same genus, helicobacter, which currently contains nine species. study of the gastric helicobacters is important because it provides relevant information about how bacteria can survive in the gastric environme ... | 1993 | 8449568 |
| pathogenic mechanisms of helicobacter pylori. | there is general agreement that motility, urease activity, and association with gastric mucosal cells are important virulence factors of h. pylori. urease activity is perhaps the best characterized of these factors. presumably, urease activity creates a "cloud" of ammonia around the bacterium, thus neutralizing the lethal effects of gastric acid. motility allows the bacterium to penetrate the mucus layer and promotes specific association of the bacteria with epithelial cells, further allowing ev ... | 1993 | 8449569 |
| microbiology of helicobacter pylori. | the new genus name helicobacter was first published in october 1989. h. pylori is a unipolar, multiflagellate, gently spiral organism found on the human gastric mucosa, but in culture and under unfavorable conditions, coccoidal forms emerge, which may be indicative of a dormant state. the biology and metabolism of h. pylori, together with growth requirements and methods of detection in clinical specimens, are described in this article. enzymes, hemagglutinins, and antibiotic susceptibilities of ... | 1993 | 8449570 |
| helicobacter pylori-associated gastric pathology. | h. pylori is the most common cause of nonerosive nonspecific gastritis; however, its main importance has been as a marker in research studies of eradication in relation to duodenal ulcer relapse. in developed countries, the most common histologic pattern appears to be that of a mild superficial chronic active gastritis. when h. pylori is present in the antrum it is virtually always present in the body as well, although inflammation in body mucosa is usually milder than that in the antrum. the or ... | 1993 | 8449571 |
| epidemiology of helicobacter pylori infection. | recent studies have shown that seroprevalence curves of helicobacter pylori infection in fact reflected the rate of acquisition in childhood. although the reservoir is well known, the routes of infection are still poorly understood: are they oral-oral or fecal-oral? | 1993 | 8449572 |
| helicobacter pylori and gastric cancer. | gastric cancer remains among the leading types of cancer worldwide. there is now convincing evidence linking h. pylori to adenocarcinomas of the gastric antrum, body, and fundus. these tumors are rapidly decreasing in incidence in the united states, whereas cardia tumors, tumors unassociated with h. pylori infection, are on the increase. although criteria for causality have not been completely fulfilled for h. pylori and adenocarcinoma, there are plausible mechanisms by which chronic inflammatio ... | 1993 | 8449573 |
| dr. apley meets helicobacter pylori. | 1993 | 8450375 | |
| helicobacter pylori infection in children: potential clues to pathogenesis. | children (227) undergoing endoscopy for upper gastrointestinal symptoms were investigated for the presence of helicobacter pylori infection. the histological response to h. pylori infection and the presence of antral nodularity and peptic ulceration were noted. symptomatic adults (258) undergoing endoscopy were also investigated for the presence of nodularity. h. pylori infection was detected histologically in 32 of 227 (14.1%) children. of those children infected with h. pylori, half (50%) had ... | 1993 | 8450376 |
| helicobacter pylori-associated gastritis in kuwait: endoscopy-based study in symptomatic and asymptomatic children. | information is limited concerning the prevalence of helicobacter pylori infection in asymptomatic children. since january 1989, we have endoscoped 60 children for recurrent abdominal pain or for obtaining small-intestinal biopsy (their ages were a mean of 6.6 (range 9 months-13 years); there were 37 boys and 23 girls. antral biopsies were obtained from all subjects and these were studied for the presence of gastritis and stained for h. pylori using modified gram's stain. all biopsies were cultur ... | 1993 | 8450377 |
| pathogenesis and early lesions in extranodal lymphoma. | extranodal lymphomas that arise in tissues normally devoid of lymphoid tissue provide a unique opportunity for the study of the pathogenesis of lymphoma without the distraction of surrounding lymphoid tissue. this applies particularly to mucosa-associated lymphoid tissue (malt) b-cell lymphomas, so named because they recapitulate the structure of normal malt rather than that of lymph nodes. before these lymphomas develop, malt accumulates, usually in response to autoimmune injury associated with ... | 1993 | 8451763 |
| [occurrence of helicobacter pylori and gastritis among healthy persons without gastrointestinal symptoms]. | 1993 | 8451786 | |
| diagnosis of helicobacter pylori infection by means of a polymerase chain reaction assay for gastric juice aspirates. | a polymerase chain reaction (pcr) assay for helicobacter pylori was developed with use of primer sequences from the urea structural gene coding for the small subunit of urease. the pcr amplification was 100% specific for h. pylori in tests with 40 stock isolates of this species and with 30 control organisms, including two species of urease-producing helicobacter. thirty-four dyspeptic patients were evaluated by culture and histologic assessment of antral biopsy samples as well as by pcr of gastr ... | 1993 | 8452948 |
| [helicobacter pylori and the treatment of gastric ulcer. reflections and uncertainties]. | the authors examine the relationship between helicobacter pylori and gastric ulcer therapy, analyzing both the data suggesting that eradication of the organism renders the gastric mucosa less susceptible to development of gastric ulcer and the substantial body of evidence to the contrary. they review the results reported in clinical trials with colloidal bismuth subcitrate, antimicrobial agents (furazolidone), and combinations of antiulcer and antimicrobial agents (h2-antagonist + cefixime, h2-a ... | 1993 | 8452981 |
| effects of atpase inhibitors on the response of hela cells to helicobacter pylori vacuolating toxin. | approximately 50% of helicobacter pylori strains produce a toxin in vitro that induces vacuolation of eukaryotic cells. to determine whether ion transport pathways are important in the formation of toxin-induced vacuoles, hela cells were incubated with h. pylori toxin in the presence of nine different inhibitors of ion-transporting atpases. oligomycin, an inhibitor of predominantly f1f0-type atpases, had no effect on toxin activity. inhibitors of predominantly v-type atpases, exemplified by bafi ... | 1993 | 8454346 |
| helicobacter pylori and gastric carcinoma. | 1993 | 8454883 | |
| can severity of symptoms be used as an outcome measure in trials of non-ulcer dyspepsia and helicobacter pylori associated gastritis? | most trials of non-ulcer dyspepsia (nud) and helicobacter pylori associated gastritis (hpag) have not used validated methods of measuring symptoms. three attributes are necessary for use of symptom severity scoring systems as outcome measures in clinical trials: reproducibility, responsiveness to change and validity compared to corroborating measures. the objective of this study was to establish that selected gastrointestinal symptoms recorded as a series of 5-point likert scales meet the 3 crit ... | 1993 | 8455052 |
| opsonic requirements of helicobacter pylori. | the opsonic requirements of helicobacter pylori were investigated in a series of experiments with human polymorphonuclear leucocytes (pmnl). pre-incubation of h. pylori with pooled normal human serum (nhs) in concentrations of 5-20% significantly increased the uptake of radiolabelled bacteria by pmnl. treatment of the bacteria with nhs 30% caused the release of radiolabel and this effect was abolished by heating serum to 56 degrees c, suggesting that h. pylori is serum-sensitive and that complem ... | 1993 | 8455190 |
| survival and ultrastructural changes of helicobacter pylori after phagocytosis by human polymorphonuclear leukocytes and monocytes. | few studies have been carried out on the phagocytosis and killing of helicobacter pylori by both polymorphonuclear leukocytes (pmns) and monocytes. in this study, h. pylori was incubated for up to 60 min either alone or with phagocytes in the presence or absence of human serum. both non-immune serum and immune serum were used. reduction in the number of h. pylori, which corresponds to the killing of h. pylori, was analysed by a colony count and ultrastructural changes were studied by electron mi ... | 1993 | 8457327 |
| unusual infections in humans. | nine cases of unusual infections in humans are presented. in each case, we present the clinical history, histopathologic changes (if indicated), morphologic features of the causative organism, diagnosis, discussion, differential diagnosis, therapy, and current literature. all of the cases are illustrated with pertinent photographs. the nine cases are as follows: (i) acanthocephaliasis, the first acquired human infection by moniliformis moniliformis in the united states; (ii) dipylidiasis, an unc ... | 1993 | 8457979 |
| [follow-up of the quantitative serological response to the treatment of helicobacter pylori infection in children]. | the aim of the present study was to know the usefulness of a enzyme immunoanalysis (eia) technique for the monitorization of the serologic to treatment of infection by helicobacter pylori in spanish children. | 1993 | 8461370 |
| [evaluation of the cut-off point in the serological diagnosis of helicobacter pylori infection in children using an enzyme immunoassay technique]. | 1993 | 8461377 | |
| helicobacter pylori may be transmitted through gastrofiberscope even after manual hyamine washing. | endoscopy is an effective diagnostic technique for gastric cancer, which is believed to be associated with helicobacter pylori. manual hyamine washing is a widely used fiberscope cleaning method. urease b gene of helicobacter pylori was detected in 50% of the wash-out samples from the biopsy-suction channel of a fiberscope after manual hyamine washing by nested polymerase chain reaction, and bacterial culture revealed viable helicobacter pylori in 19%. however, helicobacter pylori was not detect ... | 1993 | 8463128 |
| detection of helicobacter pylori in dental plaque by reverse transcription-polymerase chain reaction. | to investigate whether the oral cavity is a potential reservoir and possible sanctuary for helicobacter pylori, supragingival and subgingival plaques were analyzed by a helicobacter genus-specific reverse transcriptase-polymerase chain reaction based on the sequence data of h. pylori 16s rrna. the amplified 500-bp dna fragment was identified by ethidium bromide staining after agarose gel electrophoresis and by southern hybridization. twenty-five dyspeptic patients were studied. histologic examin ... | 1993 | 8463387 |
| bile reflux and intestinal metaplasia in gastric mucosa. | to determine associations between enterogastric bile reflux and gastric mucosal pathology. | 1993 | 8463417 |
| mucin exocytosis: a major target for helicobacter pylori. | to determine whether helicobacter pylori impairs the secretory function of mucous cells. | 1993 | 8463418 |
| [an efficient method for quantification of helicobacter pylori in biopsy specimen using pcr]. | a procedure for the detection and quantification of helicobacter pylori in gastrointestinal tissue biopsy specimens by polymerase chain reaction (pcr) is presented. this method provides an accurate quantitative and sensitive measurement of the amount of h. pylori in the gastrointestinal tract without cultivation of this microorganism. we have used 30 cycles of pcr in the presence of 3.5mm mg++ and demonstrated that the dna content of one h. pylori cell is 0.0076pg. using this approach, we analyz ... | 1993 | 8464178 |
| [peptic activity of gastric juice in chronic gastritis. morpho-functional aspects]. | the aim of this study has been to evaluate peptic activity in gastric juice and gastric peptic cell mass in chronic gastritis. as regard peptic activity, there is a close correlation between it and the peptic gastric cell mass considered globally and expressed as peptic gastric index (pgi), resulting from the individual average between fundic peptic index (chief cells + fundic muco-peptic cells) and antral peptic index (antral muco-peptic cells), both obtained by multiplying the number of peptic ... | 1993 | 8464563 |
| prevalence of antibody to helicobacter pylori in children in northern nigeria. | helicobacter pylori infection is common in northern nigeria, but the age of acquisition is unknown. in a prospective study, immunoglobulin g antibodies to h. pylori were measured in 143 children under the age of 20 years. ninety-one percent of 43 randomly chosen subjects over 10 years had antibodies to h. pylori. a further 100 children under 10 years presenting to the university of maiduguri teaching hospital were also tested. sixty-nine percent had antibodies, including 58% of those aged under ... | 1993 | 8465385 |
| the 13c-urea breath test--detection of helicobacter pylori infection in patients with partial gastrectomy. | the 13c-urea breath test (13c-ubt) for diagnosis of helicobacter pylori (hp) infection was evaluated in 41 patients after partial gastrectomy and was used for determination of the hp-prevalence after two different procedures of reconstruction of the gastrointestinal tract, i.e. billroth's ii operation and roux-en-y anastomosis. breath samples were taken at various time points within 30 minutes after a motility inhibiting liquid test meal with citric acid followed by 75 mg of 13c-urea. the 13co2/ ... | 1993 | 8465552 |
| helicobacter pylori infection. rapid diagnosis with brush cytology. | the validity of brush cytology of the gastric mucosa with diff-quik rapid staining was studied in 69 samples, and its effectiveness was compared with two other techniques (culture and urease test). brush cytology is the method of choice for detecting helicobacter pylori since it is rapid, easy to perform and has good sensitivity and specificity. | 1993 | 8465638 |
| serum anti-helicobacter pylori igg antibodies and pepsinogens a and c as serological markers of chronic atrophic gastritis. | this study was designed to test the sensitivity and specificity of serum anti-helicobacter pylori igg antibodies and the ratio of serum pepsinogen a to pepsinogen c (pga:pgc) in detecting chronic atrophic gastritis (cag) and intestinal metaplasia. parallel gastric biopsies and a serum sample were collected from a series of 87 patients aged 20-69 years attending a routine upper endoscopy clinic. the seroprevalence (> 10 micrograms igg/ml) of anti-h. pylori antibodies was 42.7%, and of a low pga:p ... | 1993 | 8467246 |
| a computer program in quickbasic for the selection of tests for the identification of helicobacter pylori. | reliable microbiological tests are needed for the identification of bacteria. a program has been written in quickbasic to identify such tests by using a formula that is based on gyllenberg's sum of c(i) and gyllenberg's rank r(i). a total of 139 papers on a newly isolated bacterium, helicobacter pylori, was used as data source for the coding of test results into an input file. the program outputs a list that aids in the determination of suitable tests for the identification of h. pylori. these t ... | 1993 | 8467636 |
| helicobacter pylori and peptic ulcer disease. | 1993 | 8468160 | |
| 14c-urea breath test--a simple, noninvasive method for the detection of helicobacter pylori infection. | 1993 | 8468178 | |
| [differences in susceptibility of helicobacter pylori to macrolide and other antibiotics in tests using blood agar and albumin agar]. | minimum inhibitory concentrations (mics) of penicillin g, cefazolin, tetracycline, chloramphenicol, four aminoglycosides, and seven macrolides against helicobacter pylori strains were determined on brucella agar supplemented with bovine serum albumin fraction v (albumin agar) and compared with those on blood agar. mics of the macrolides against h. pylori determined on albumin agar were markedly lower than those found with blood agar. the susceptibilities of 26 h. pylori strains to the macrolides ... | 1993 | 8468498 |
| ph and hp--gastric acid secretion and helicobacter pylori: implications for ulcer healing and eradication of the organism. | 1993 | 8470623 | |
| omeprazole plus amoxicillin: efficacy of various treatment regimens to eradicate helicobacter pylori. | in five subsequent open clinical studies, 180 patients with helicobacter pylori (hp)-associated ulcer disease (n = 163) or severe functional dyspepsia (n = 17) requiring therapy were treated with either 40 mg omeprazole plus 4 x 500 mg amoxicillin suspension for 1 wk (group i, n = 35), 2 x 40 mg omeprazole plus 4 x 500 mg amoxicillin for 1 wk (group ii, n = 50), 2 x 20 mg omeprazole plus 4 x 500 mg amoxicillin for 2 wk (group iii, n = 62), 2 x 20 mg omeprazole (day 1-14) and 4 x 500 mg amoxicill ... | 1993 | 8470626 |
| patient factors affecting helicobacter pylori eradication with triple therapy. | duodenal ulcer recurrence and gastritis are reduced with successful helicobacter pylori treatment. to identify the patient factor influencing h. pylori eradication, we prospectively evaluated 96 consecutive patients undergoing a single 2-wk course of bismuth, tetracycline, and metronidazole therapy. at the time of initial esophagogastroduodenoscopy with biopsies, each patient had a profile obtained which included demographic information, gastrointestinal pathology, and h. pylori status of the sp ... | 1993 | 8470629 |
| esophagitis and helicobacter pylori in children: incidence and therapeutic implications. | the relationship between gastric helicobacter pylori colonization and esophagitis was determined in 457 children undergoing endoscopic evaluation of abdominal pain and/or vomiting. in all patients, biopsies of the esophagus were examined histologically, and two antral biopsies were analyzed for the presence of h. pylori, using standard microbiological and histochemical techniques. the incidence of biopsy-proven esophagitis was similar in h. pylori-positive (15/56 patients) and -negative (94/401; ... | 1993 | 8470630 |
| helicobacter pylori does not increase gastrin in chronic gastritis. | 1993 | 8470651 | |
| gastric cancer and helicobacter pylori infection. | gastric adenocarcinoma can be divided into two histopathological types: intestinal and diffuse. in addition to the role of environmental factors, an association between gastric cancer and helicobacter pylori has been suggested. a retrospective study was therefore carried out among 46 patients who had gastric cancer. as a control group, 40 patients with non-malignant disorders were selected (11 patients with peptic ulcer, 12 with chronic superficial gastritis, 17 with chronic atrophic gastritis). ... | 1993 | 8472158 |
| helicobacter pylori: 10th anniversary of its culture in april 1982. | 1993 | 8472974 | |
| effect of ranitidine bismuth citrate on postprandial plasma gastrin and pepsinogens. | ranitidine bismuth citrate was compared with an equipotent dose of ranitidine, to determine whether the former, by an anti-helicobacter pylori activity, would counteract the rise of gastrin resulting from ranitidine's gastric acid antisecretory activity. twenty four men with duodenal ulcers were studied before and on the 8th day of dosing with either ranitidine bismuth citrate 800 mg twice daily or ranitidine 300 mg twice daily (double blind, randomised, parallel groups). fasting and postprandia ... | 1993 | 8472980 |
| secretor status and helicobacter pylori infection are independent risk factors for gastroduodenal disease. | the hypothesis that non-secretors of abo blood group antigens, a group shown to be more susceptible to certain bacterial infections, may be at greater risk of gastroduodenal disease because of increased susceptibility to helicobacter pylori infection was investigated. of 101 patients with symptoms of dyspepsia who were undergoing endoscopy, 32% were non-secretors (determined from lewis blood group phenotype), 36% had endoscopically visible gastroduodenal disease (antral gastritis, gastric ulcer, ... | 1993 | 8472982 |
| prevalence of metronidazole-resistant helicobacter pylori in dyspeptic patients. | susceptibility to metronidazole of 213 clinical strains of h. pylori from dyspeptic patients was determined by a plate dilution method. seventy two (33.8%) of the strains were resistant to metronidazole (mic > 8 mg/l), 20 of these were from 24 patients who had received previously metronidazole (83.3%), giving a primary (pretreatment) resistance rate of 27.5% (52/189). the resistance rate was higher in women than in men, especially aged 50 to 59 years old (43.6% vs 23.3%, p < 0.001). the resistan ... | 1993 | 8473130 |
| characterisation of a helicobacter pylori phage (hp1). | the infection of two helicobacter pylori strains with a phage-containing supernate of the lysogenic h. pylori strain immi 290/89 resulted in a lytic cycle and propagation of phage hp1. in negatively-stained preparations, the empty phage heads measured 55-60 nm in diameter and mature heads measured 50 nm. the flexible, striated phage tail was c. 170 nm in length and 9.5 nm in diameter. the phage showed a mean density of 1.40 g/cm3 in sucrose-density gradients and contained double-stranded dna c. ... | 1993 | 8474115 |
| genetic transformation in helicobacter pylori. | genetic transformation in helicobacter pylori was investigated by using its chromosomal and plasmid dnas. six out of the eight strains exhibited the natural competence for incorporation of h. pylori chromosomal dna, and all the strains incorporated the donor dna efficiently by washing and concentrating the cells with a glycerol solution. the much higher frequency of transformation was obtained in each strain by means of electroporation. electroporation experiments were also conducted by use of t ... | 1993 | 8474363 |
| ulcer risk factors: interactions between helicobacter pylori infection, nonsteroidal use, and age. | to evaluate the influence of helicobacter pylori, nonsteroidal anti-inflammatory drug (nsaid) use, tobacco and alcohol use, age, gender, ethnic group, and the indication for endoscopy on the frequency of gastric and duodenal ulcers in patients referred for upper endoscopy. | 1993 | 8475935 |
| pathogenicity of helicobacter pylori: a perspective. | 1993 | 8478048 | |
| cloning and expression of a high-molecular-mass major antigen of helicobacter pylori: evidence of linkage to cytotoxin production. | a high-molecular-mass (120- to 128-kda) helicobacter pylori antigen has been associated with peptic ulcer disease. we created a bank of 40,000 random chromosomal fragments of h. pylori 84-183 by using lambda zapii. screening of this bank in escherichia coli xl1-blue with absorbed serum from an h. pylori-infected person permitted the isolation and purification of a clone with a 3.5-kb insert. subcloning of this insert (pmc3) permitted the expression of a recombinant h. pylori protein that had a m ... | 1993 | 8478069 |