Publications

developmental changes of thyroid hormones in the fathead minnow, pimephales promelas.	the fathead minnow is widely used in ecotoxicological studies and such investigations have begun to focus on potential disruption of the thyroid axis. however, normal levels of thyroxine (t4) and 3,5,3'-triiodothyronine (t3) and their developmental patterns are unknown. to provide these baseline data, radioimmunoassays were developed and validated for analysis of t4 and t3 after extraction from plasma or whole fish. female fish showed consistently higher plasma levels of t4 than male fish. analy ...	2004	15474536
histone deacetylase 1 mrna expression in lung cancer.	histone deacetylases (hdacs) play a crucial role in tumorigenesis, however, the expression status of hdacs in lung cancer tissues has not been reported. we have investigated that hidac 1 mrna levels and other clinico-pathological data, including mta 1 mrna expression in lung cancer. the study included 102 lung cancer cases. the hdac1 mrna levels were quantified by real time reverse transcription-polymerase chain reaction (rt-pcr) using lightcycler (roche molecular biochemicals, mannheim, germany ...	2004	15474665
delayed spinal cord injury following electrical burns: a 7-year experience.	although delayed spinal cord injury following high-voltage electrical burn is not a life-threatening sequelae, complete recovery is not the rule and the morbidity is high. in this study, we conducted a detailed analysis of clinical characteristics, radiographic findings and clinical outcomes in 13 patients with delayed spinal cord injury following electrical burns. the following features were notable. in 11 patients whose entry sites were the head and neck area, paraplegia was detected in cases ...	2004	15475144
chemotherapy is more effective in patients with breast cancer not expressing steroid hormone receptors: a study of preoperative treatment.	the purpose of this research was to identify factors predicting response to preoperative chemotherapy.	2004	15475452
interleukin-18, a proinflammatory cytokine, contributes to the pathogenesis of non-thyroidal illness mainly via the central part of the hypothalamus-pituitary-thyroid axis.	proinflammatory cytokines are involved in the pathogenesis of non-thyroidal illness (nti), as shown by studies with il-6-/- and il-12-/- mice. interleukin (il)-6 changes peripheral thyroid hormone metabolism, and il-12 seems to be involved in the regulation of the central part of the hypothalamic-pituitary-thyroid (hpt) axis during illness. il-18 is a proinflammatory cytokine which shares important biological properties with il-12, such as interferon (ifn)-gamma-inducing activity.	2004	15476451
phage-induced change in the stability of mrnas.	the stability of mrna in escherichia coli cells changed after phage t4 infection. stable e. coli mrnas such as lpp and ompa were drastically destabilized immediately after infection. in contrast, t4 phage soc mrna that had been unstable before infection became stabilized after infection. the host rnases e and g both contributed to the destabilization of these mrnas. accordingly, these rnases may alter their target rnas before and after infection. an rna chaperon, hfq, and polyadenylation at 3' e ...	2004	15476881
acanthamoeba keratitis in non-contact lens wearers in india: dna typing-based validation and a simple detection assay.	to establish that the protozoan acanthamoeba is one of the causative organisms associated with non-contact lens-related keratitis in the indian population and to develop a simple and sensitive diagnostic assay for clinical testing.	2004	15477452
urolithiasis associated with indinavir in a patient with spinal cord injury.	to report a case of indinavir-induced urolithiasis, and the greater risk of this occurrence in individuals with spinal cord injury (sci) who require fluid restriction for an intermittent catheterization program (icp).	2004	15478531
neonatal chemical hypothyroidism in nigeria.	to investigate the level of neonatal chemical hypothyroidism (nch), thyroid function was measured in the cord blood of 271 neonates in an area with a high prevalence of endemic goitre, bassa (n = 140), and a nonendemic area, jos (n = 131), in plateau state, nigeria. nch was defined as t4 < 40 nmol/l and tsh > 49 mu/l and borderline compensated nch as t4 31-50 nmol/l and tsh 41-49 mu/l. nch was detected in 16.4% of neonates in bassa and in 3.8% in jos. borderline compensated nch was detected in a ...	2004	15479573
vertebral wedging characteristic changes in scoliotic spines.	a morphometric analysis of vertebral wedging in vertebrae from scoliotic specimens.	2004	15480123
long term changes in serum t4, t3, and tsh in benign thyroid disease: proof of a narrow individual variation.	the diagnosis of abnormalities of thyroid function is generally based on the measurement of thyroid hormones and tsh in blood. the recommended reference ranges for serum t4 and t3 as well as tsh are quite wide as the result of large differences in thyroid function tests in healthy persons. it has been proven that the individual variation within an individual is small, compared with the variation between individuals. we investigated long term variations of these parameters in patients with and wi ...	2004	15480504
isolation and characterization of a cellulolytic geobacillus thermoleovorans t4 strain from sugar refinery wastewater.	a novel, cellulolytic, bacterial thermophilic strain, t4, was isolated from sugar refinery wastewater in southern taiwan. this isolate, a gram-negative, motile, aerobically growing sporulating rod, can secrete thermostable endocellulase (endo-1,4-beta-d-glucanase, ec 3.2.1.4) and hydrolyze carboxymethylcellulose (cmc), phosphoric acid-swollen cellulose, avicel, filter paper, and salicin. when strain t4 was grown in cmc medium, the cellulolytic enzyme activity in culture supernatants was stable u ...	2004	15480864
free thyroxine measured with equilibrium dialysis and nine immunoassays decreases in late pregnancy.	we measured free thyroxine in sera from 29 women in the ninth month of pregnancy. we used the reference method, equilibrium dialysis, and nine immunoassays. the bias between immunoassay and dialysis results was insignificant or modest. with all methods, the results were in the lower part of the non-pregnant female reference interval or below the lower limit of this interval: 10 results with the equilibrium dialysis assay and from 4 to 18 results with the nine immunoassays. method-specific refere ...	2004	15481634
case report: spontaneous spinal epidural haematoma during pregnancy: case report and review of the literature.	spontaneous epidural haematoma is rare in pregnancy and only five cases have been reported. we present a case of a 31-year-old female g2p1 who at 32 weeks of gestation developed progressive ascending paralysis and numbness to a level of approximately t4. an urgent mri of the spine was performed, which demonstrated a posterior epidural lesion at t1-t4 level. the lesion showed signal changes consistent with an epidural haematoma in the hyperacute stage. an emergency cesarean section was performed ...	2004	15483004
[factors associated with postoperative mortality following gastric adenocarcinoma surgery at the edgardo rebagliati martins hospital].	this study is a retrospective, descriptive and observational evaluation aimed at defining the factors associated with postoperative mortality due to gastric adenocarcinoma and evaluating postoperative morbidity at the edgardo rebagliati martins hospital.	2004	15483682
performance of mouse lines divergently selected for heat loss when exposed to different environmental temperatures. i. reproductive performance, pup survival, and metabolic hormones.	mouse populations differing in metabolic rate have been developed through selection for high (mh) and low (ml) heat loss, along with the unselected controls (mc). objectives of the study were to compare the mh, ml, and mc lines for reproductive performance, pup survival, and metabolic hormones when reared at 12, 22, and 31 degrees c, and to search for line x environment interactions. conception and litter size were recorded on the parent generation mice introduced to the environments at 11 wk of ...	2004	15484937
effect of se on selenoprotein activity and thyroid hormone metabolism in beef and dairy cows and calves.	although se is essential for antioxidant and thyroid hormone function, factors influencing its requirement are not well understood. a survey and two experiments were conducted to determine the influence of cattle breed and age on selenoprotein activity and the effect of maternal se supplementation on cow and calf selenoprotein activity and neonatal thyroid hormone production. in our survey, four cowherds of different ages representing three breeds were bled to determine the influence of breed an ...	2004	15484952
the sequences and activities of regb endoribonucleases of t4-related bacteriophages.	the regb endoribonuclease encoded by bacteriophage t4 is a unique sequence-specific nuclease that cleaves in the middle of ggag or, in a few cases, ggau tetranucleotides, preferentially those found in the shine-dalgarno regions of early phage mrnas. in this study, we examined the primary structures and functional properties of regb ribonucleases encoded by t4-related bacteriophages. we show that all but one of 36 phages tested harbor the regb gene homologues and the similar signals for transcrip ...	2004	15486207
[recurrent micro-satellite stable colonic cancer: prolonged survival of 16 years without adjuvant therapy].	long-term survival in malignant disease is often linked to intensified therapeutic interventions. we report the case of a colonic cancer in a 78 years old female patient, who underwent her first operation in 1987 for a symptomatic t4 carcinoma. since then, the patient has always denied any form of follow-up examination and adjuvant therapy. recently, she has undergone her fourth operation, which for the first time demonstrated peritoneal carcinosis, and is still in very good health.clinical expe ...	2004	15486798
extending low-dose epidural analgesia for emergency caesarean section using ropivacaine 0.75%.	we compared ropivacaine 0.75% and bupivacaine 0.5% for extending low-dose epidural analgesia for emergency caesarean section, using a prospective double-blind randomised controlled trial design. the trial was halted after 45 patients were studied (23 ropivacaine; 22 bupivacaine) because bupivacaine was replaced by levobupivacaine in our unit. time to reach t4 for loss of cold sensation was similar in both groups, although analgesic supplementation was required less often in the ropivacaine group ...	2004	15488058
lactobacillus plantarum bacteriophage lp65: a new member of the spo1-like genus of the family myoviridae.	the virulent lactobacillus plantarum myophage lp65 was isolated from industrial meat fermentation. tail contraction led to reorganization of the tail sheath and the baseplate; a tail tube was extruded. in ultrathin section the phage adsorbed via its baseplate to the exterior of the cell, while the tail tube tunneled through the thick bacterial cell wall. convoluted membrane structures were induced in the infected cell. progeny phage was detected 100 min postinfection, and lysis occurred after ex ...	2004	15489418
moda and modb, two adp-ribosyltransferases encoded by bacteriophage t4: catalytic properties and mutation analysis.	bacteriophage t4 encodes three adp-ribosyltransferases, alt, moda, and modb. these enzymes participate in the regulation of the t4 replication cycle by adp-ribosylating a defined set of host proteins. in order to obtain a better understanding of the phage-host interactions and their consequences for regulating the t4 replication cycle, we studied cloning, overexpression, and characterization of purified moda and modb enzymes. site-directed mutagenesis confirmed that amino acids, as deduced from ...	2004	15489438
thyroid hormone binding protein abnormalities in patients referred for thyroid disorders.	thyroid hormone binding protein (thbp) abnormalities are the major cause of discordance in commonly performed total thyroxine (t4) and thyrotropin (tsh) estimations, though these do not interfere with thyroid hormone action. determination of such abnormalities in patients showing discordant thyroid function tests (tfts) is diagnostically important as it eliminates equivocal assessment of thyroid function and treatment especially where proper methodology for free t4 (ft4) estimation is not availa ...	2004	15489553
clinical analysis of thyroid cancer in adult patients exposed to ionizing radiation due to the chernobyl nuclear accident: 5-year comparative investigations based on the results of surgical treatment.	the aim of study was to compare clinical and pathologic findings of surgically removed thyroid tumors in adults with or without history of irradiation due to the chernobyl accident. from 1990 to 2003, 2363 adults with no evidence of radiation influence in their history (group a) have undergone operation for thyroid nodules. during the same period, 311 patients (born before 1969) with strict evidence of chernobyl irradiation also underwent operation (group b). both groups were similar in age, sex ...	2004	15490064
prognostic factors of maxillary sinus malignancies.	analysis of a series of tumors of the maxillary sinus show contradictory outcome data. the purpose of this article was to study the prognostic factors that may have implications for patient management.	2004	15490570
genotypic diversity of oral actinomyces naeslundii genospecies 1 and 2 in caries-active preschool children.	a total of 991 isolates of actinomyces naeslundii were obtained from sound approximal tooth sites in either caries-active (n = 35) or caries-free (n = 20) preschool children. from this group of isolates, 101 strains were chosen to study the genotypic diversity of a. naeslundii genospecies 1 (n = 30), catalase-positive (n = 30), and catalase-negative genospecies 2 (n = 41). polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp), with a pair of primers targeting the 16s ribo ...	2004	15491462
local recurrence after radical cystectomy for invasive bladder cancer: an analysis of predictive factors.	to examine which clinicopathologic parameters predict clinically detectable local recurrence after radical cystectomy. local recurrence after radical cystectomy for invasive bladder cancer was infrequently observed until 20 years ago because of the lack of adequate diagnostic tools. the recent development and use of pelvic computed tomography has allowed us to detect local recurrence more precisely. however, only a few studies have investigated the rate and pattern of local recurrence in the com ...	2004	15491713
association of nucleophosmin/b23 mrna expression with clinical outcome in patients with bladder carcinoma.	to determine whether nucleophosmin/b23 mrna expression in bladder carcinoma predicts recurrence, progression, and survival.	2004	15491744
synthesis and properties of monodisperse oligofluorene-functionalized truxenes: highly fluorescent star-shaped architectures.	this paper describes the strategy toward novel monodisperse, well-defined, star-shaped oligofluorenes with a central truxene core and from monofluorene to quaterfluorene arms. introduction of solubilizing n-hexyl groups at both fluorene and truxene moieties results in highly soluble, intrinsically two-dimensional nanosized macromolecules t1-t4. the radius for the largest oligomer of ca. 3.9 nm represents one of the largest known star-shaped conjugated systems. cyclic voltammetry experiments reve ...	2004	15493927
analysis of gaa/ttc dna triplexes using nuclear magnetic resonance and electrospray ionization mass spectrometry.	the formation of a gaa/ttc dna triplex has been implicated in friedreich's ataxia. the destabilization of gaa/ttc dna triplexes either by ph or by binding to appropriate ligands was analyzed by nuclear magnetic resonance (nmr) and positive-ion electrospray mass spectrometry. the triplexes and duplexes were identified by changes in the nmr chemical shifts of h8, h1, h4, 15n7, and 15n4. the lowest ph at which the duplex is detectable depends upon the overall stability and the relative number of ho ...	2004	15494127
how an rna ligase discriminates rna versus dna damage.	t4 rna ligase 2 (rnl2) exemplifies a family of rna-joining enzymes that includes protozoan rna-editing ligases. rnl2 efficiently seals 3'-oh/5'-po4 rna nicks in either a duplex rna or an rna:dna hybrid but cannot seal dna nicks. rna specificity arises from a requirement for at least two ribonucleotides immediately flanking the 3'-oh of the nick; the rest of the nicked duplex can be replaced by dna. the terminal 2'-oh at the nick is important for the attack of the 3'-oh on the 5'-adenylated stran ...	2004	15494308
preoperative versus postoperative chemoradiotherapy for rectal cancer.	postoperative chemoradiotherapy is the recommended standard therapy for patients with locally advanced rectal cancer. in recent years, encouraging results with preoperative radiotherapy have been reported. we compared preoperative chemoradiotherapy with postoperative chemoradiotherapy for locally advanced rectal cancer.	2004	15496622
["euthanasia"--victims and test subjects. the fate of diseased, disabled children in berlin during world war ii].	this article shows, through a study of the berlin-brandenburg region, that children and juveniles who were subjected to the killings of diseased and disabled, or mentally retarded, persons during the third reich did not only fall victim to the operations of the "reichsausschuss" ("reich commission for registration of severe disorders in childhood"). many were also included in the gas chamber killings of the "t4"-action and in various decentralized killing actions. furthermore, the co-operation o ...	2004	15497481
electrographic imaging of recognition memory in 34-38 week gestation intrauterine growth restricted newborns.	electrophysiological imaging of recognition memory using event-related potentials (erps) in intrauterine growth-restricted (iugr) newborns allows assessment of recognition memory before the onset of multiple confounding variables. animal models that reproduce the physiologic components associated with iugr have demonstrated adverse effects on the hippocampus, a structure that is essential to normal memory processing. previous electrophysiologic studies have demonstrated shortened auditory-evoked ...	2004	15498545
d(g3t4g4) forms unusual dimeric g-quadruplex structure with the same general fold in the presence of k+, na+ or nh4+ ions.	we have recently communicated that dna oligonucleotide d(g(3)t(4)g(4)) forms a dimeric g-quadruplex in the presence of k(+) ions [j. am. chem. soc.2003, 125, 7866-7871]. the high-resolution nmr structure of d(g(3)t(4)g(4))(2) g-quadruplex exhibits g-quadruplex core consisting of three stacked g-quartets. the two overhanging g3 and g11 residues are located at the opposite sides of the end g-quartets and are not involved in g-quartet formation. d(g(3)t(4)g(4))(2) g-quadruplex represents the first ...	2004	15498650
dna repair, immunosuppression, and skin cancer.	uv radiation (uvr) produces erythema within the first 24 hours of exposure, suppression of the immune system within the first 10 days, and, for many people, over the course of decades, skin cancer. although uvr damages many skin targets, dna damage in the form of cyclobutane pyrimidine dimers (cpds) is an important mediator of these sequelae. the action spectrum for erythema parallels the action spectrum for cpd formation in skin, and in the absence of repair, as in the genetic disease xeroderma ...	2004	15603216
[vascular invasion by tumor in the absence of regional lymph node metastases in patients with locally advanced non-small cell lung cancer].	the study included 45 patients radically operated for locally advanced (t3, t4) non-small cell lung cancer (nsclc), free from metastasis to the regional lymph nodes. the histological subtypes were: squamous cell cancer (40; 89%), adenocarcinoma (4; 6%) and large-cell lung cancer (1; 2%). pathomorphological stage: iib (p t3n0m0)--35 (78%); iiib (p t4n0m0)--10 (22%). blood vessel invasion: tumor t3--8 (23%); t4--2 (20%). lymph vessel invasion: t3--9 (9%) and t4--2 (2%) (p(0.05). in total, tumor in ...	2004	15605763
consolidation-like effects in flashbulb memories: evidence from september 11, 2001.	after september 11, 2001, we distributed flashbulb memory questionnaires at 5 different dates: within 48 hr (t1) and at 1 week (t2), 1 month (t3), 3 months (t4), and 1 year (t5). we scored responses for self-reported memory (veracity unverified), memory accuracy (recollection-matched t1 response), and memory consistency (recollection-matched prior responses other than t1). self-reported memory and subjective confidence remained near ceiling, although the accuracy declined. however, memories give ...	2004	15605956
[clinical analysis of 57 patients with poorly differentiated carcinomas of the supraglottic larynx].	to investigate the clinical characteristics, treatment and prognosis for poorly differentiated supraglottic carcinomas.	2004	15606009
a comparison of treatments of squamous cell carcinoma of the base of tongue: surgical resection combined with external radiation therapy, external radiation therapy alone, and external radiation therapy combined with interstitial radiation.	the outcomes of patients treated at a single institution over a specific time frame using three different therapeutic approaches for cancer of the base of tongue were reviewed.	2004	15607157
discovery of thoracic meningioma with cord compression on a screening "total body" computed topography scan.	the use of "total body" screening computed tomography (ct)scans has increased dramatically, although the procedure is controversial, and its benefit to the patient is unproven. when a screening ct scan of the chest is performed, the major areas of interest are the heart and lungs. however, significant portions of the spinal column are also included in the examination.	2004	15597483
triplets! unexpected structural similarity among the three enzymes that catalyze initiation and termination of thyroid hormone effects.	the three iodothyronine deiodinases catalyze the initiation (d1, d2) and termination (d3) of thyroid hormone effects in vertebrates. a recently conceived 3-dimensional model predicts that these enzymes share a similar structural organization and belong to the thioredoxin (trx) fold superfamily. their active center is a selenocysteine-containing pocket defined by the beta1-alpha1-beta2 motifs of the trx fold and a domain that shares strong similarities with the active site of iduronidase, a membe ...	2004	15611815
[subclinical thyroid disease: subclinical hypothyroidism and hyperthyroidism].	subclinical hypothyroidism (sht) and subclinical hyperthyroidism (sch) are defined as normal serum free t4 and t3 levels associated with elevated (sht) or subnormal (sch) serum tsh levels, respectively. symptoms and signs of thyroid dysfunction are scarce. the prevalence is low. in sht, total cholesterol and ldl-c are modestly elevated and levothyroxine may influence the lipids levels. there is decreased cardiac contractility and increased peripheral vascular resistance that improve with treatme ...	2004	15611827
[thyrotoxic hypokalemic periodic paralysis, an endocrine emergency: clinical and genetic features in 25 patients].	thyrotoxic hypokalemic periodic paralysis (thpp) is a medical emergency characterized by acute attacks of weakness, hypokalemia, and thyrotoxicosis that resolve with the treatment of hyperthyroidism. attacks are transient, self-limited, associated with hypokalemia and resemble those of familial hypokalemic periodic paralysis (fhpp), an autosomal dominant neurological channelopathy. this study reviews the clinical features and genetic findings of thpp in 25 brazilian patients. most patients had w ...	2004	15611833
fatigue patterns and correlates in male liver cancer patients receiving transcatheter hepatic arterial chemoembolization.	liver cancer is a leading cancer in taiwan, especially in males. transcatheter arterial chemoembolization (tace) is a major treatment for these patients, but research examining their fatigue experiences is limited. the purposes of this longitudinal, correlational study were to identify (1) changes in fatigue, symptom distress, anxiety and depression in cancer patients across four time points during the first week of tace treatment, and (2) factors predicting changes in fatigue across the four ti ...	2004	15611851
[carcinoma of the external auditory canal and middle ear: therapeutic strategy and follow up].	carcinomas of the external auditory canal (eac) and the middle ear are rare and considered to have a poor prognosis. the recommended therapeutic strategy consists of surgical excision and postoperative radiotherapy. however, there are different opinions about the extend of the primary operation.	2004	15611900
the role of peripheral chemoreceptor activity on the respiratory responses to hypoxia and hypercapnia in anaesthetised rabbits with induced hypothyroidism.	the purpose of this study was to investigate the role of peripheral chemoreceptor activity on the hypoxic and hypercapnic ventilatory drives in rabbits with induced hypothyroidism. experiments were carried out in control and hypothyroid rabbits. hypothyroidism was induced by an administration of an iodide-blocker, methimazole in food (75 mg/100 g food) for ten weeks. at the end of the tenth week, triiodothyronine (t3) and thyroxine (t4) levels significantly decreased (p<0.001) while thyroid stim ...	2004	15612533
matrix metalloproteinases 2 and 9 in oral squamous cell carcinomas: manifestation and localization of their activity.	the process of invasion and metastasis is closely related to the prognosis of oral squamous cell carcinoma (oscc). matrix metalloproteinases (mmps) are a group of enzymes characterized by their ability to degrade extracellular matrix proteins and contribute to the tumor invasion and metastasis. especially mmp-2 and mmp-9 are known to be related to destruction of basement membrane as collagenases. this study focused on protein expression of mmp-2 and mmp-9 and their extracellular matrix degradati ...	2004	15614523
thermal manipulations during broiler chick embryogenesis: effects of timing and temperature.	this study aimed at elucidating the effects of thermal manipulation (tm) during different periods of embryogenesis on hatchability, body weight, and thermoregulation of ross chicks at hatch, and on the chick's ability to cope with thermal challenge (tc) at 3 d of age. control embryos were incubated at 37.8 degrees c and 56% rh, whereas the tm embryos were treated for 3 h at 39.5 (1) or 41.0 degrees c (2) and 65% rh, during early embryogenesis (ee), e8 to e10, and late embryogenesis (le) at e16 t ...	2004	15615007
[bioequivalence of l-thyroxine tablets and a liquid l-thyroxine solution in the treatment of hypothyroid patients].	the therapeutic equivalence of l-thyroxine (t(4)) tablets and a new liquid t(4) solution was investigated in patients with hypothyroidism.	2004	15583873
an extended use of the sentinel node in head and neck squamous cell carcinoma: results of a prospective study of 100 patients.	most studies concerning the use of the sentinel node technique in head and neck cancers have included clinically n0 patients with primary early stage tumours of the oral cavity or upper part of oropharynx; furthermore, node sampling has been performed during the same session, but separately from the tumour. the perspective of avoiding unnecessary neck dissection, without increasing the risk of delayed diagnosis of lymph node metastasis, is rewarding, not only for early stage tumours of the oral ...	2004	15584585
docetaxel and cisplatin as primary chemotherapy for treatment of locally advanced breast cancers.	a phase ii trial was designed to evaluate the effectiveness of docetaxel/cisplatin as primary or neoadjuvant chemotherapy of locally advanced breast carcinoma (labc). patients with newly diagnosed breast cancers > or = 5 cm in size by palpation were treated with docetaxel/cisplatin, both at 70 mg/m2 intravenously every 21 days for 4 courses. upon completion of chemotherapy, all patients underwent modified radical mastectomy with axillary nodal dissection. pathologic complete response (pcr) was d ...	2004	15585076
partial substitution of thyroxine (t4) with tri-iodothyronine in patients on t4 replacement therapy: results of a large community-based randomized controlled trial.	conflicting results have recently been published about the benefits of combined t(4) and t(3) in treating hypothyroid patients. however, these studies may have been underpowered to detect differences in psychological well-being specifically related to t(4) replacement. we conducted a large, double-blind, randomized controlled trial of partial substitution of 50 microg t(4) by 10 microg t(3) vs. the original dose of t(4) in 697 hypothyroid patients. thyroid function showed a rise in tsh (132%), a ...	2004	15585551
[changes in the provision of psychiatric services at a psychiatric district hospital].	changes in the provision of psychiatric services within the last decennials are probably best understood if the impact of national socialism on clinical psychiatry is regarded. many psychiatrists took part in the "aktion t4" the organised killing of their patients, at least they did not resist campaigns directed to killing or sterilisation patients. after ww ii, a period of silence and acceptance of inhuman circumstances in the large mental state hospitals appeared, when in the sixties a new gen ...	2004	15586320
ocular surface changes in laser in situ keratomileusis-induced neurotrophic epitheliopathy.	to evaluate the ocular surface changes in patients with laser in situ keratomileusis (lasik)-induced neurotrophic epitheliopathy.	2004	15586763
a patient with low free t4 and low thyroid-stimulating hormone without hypopituitarism.	a 39-year-old entertainer was referred in november 2000 for suspected secondary hypothroidism found during a routine insurance check. thyroid stimulating hormone (tsh) was 0.30 miu/l (nr 0.47-4.68 miu/l) and total t4 was 21.6 nmol/l (nr 57.9-154.4 nmol/l). she had enjoyed good past health and gave birth to a baby girl at 32 weeks gestation in july 2000. she was clinically euthyroid and there was no goiter. menses was regular with oral contraception. thyroid function was rechecked with free t4 7. ...	2004	15587780
effects of increased thyroxine dosage pre-conception on thyroid function during early pregnancy.	to compare the effects of pregnancy on the serum free thyroxine (ft4) levels in two cohorts of primary hypothyroid women treated with different levothyroxine (l-t4) doses before gestation.	2004	15588235
effects of thyroxine and 1-methyl, 2-mercaptoimidazol on phosphoinositides synthesis in rat liver.	phosphoinositides mediate one of the intracellular signal transduction pathways and produce a class of second messengers that are involved in the action of hormones and neurotransmitters on target cells. thyroid hormones are well known regulators of lipid metabolism and modulators of signal transduction in cells. however, little is known about phosphoinositides cycle regulation by thyroid hormones. the present paper deals with phosphoinositides synthesis de novo and acylation in liver at differe ...	2004	15588322
combined t4 and t3 therapy.		2004	15588389
treatment of nasopharyngeal carcinoma with intensity-modulated radiotherapy: the hong kong experience.	to evaluate the efficacy of using intensity-modulated radiotherapy (imrt) in the primary treatment of nasopharyngeal carcinoma (npc), including the role of dose escalation above 66 gy level.	2004	15590175
esophagectomy after concurrent chemoradiotherapy improves locoregional control in clinical stage ii or iii esophageal cancer patients.	to evaluate the effect of surgical resection on the outcome of patients with clinical stage ii or iii cancer of the esophagus treated with concurrent chemoradiotherapy.	2004	15590179
effects of carnitine on thyroid hormone action.	by experiments on cells (neurons, hepatocytes, and fibroblasts) that are targets for thyroid hormones and a randomized clinical trial on iatrogenic hyperthyroidism, we validated the concept that l-carnitine is a peripheral antagonist of thyroid hormone action. in particular, l-carnitine inhibits both triiodothyronine (t3) and thyroxine (t4) entry into the cell nuclei. this is relevant because thyroid hormone action is mainly mediated by specific nuclear receptors. in the randomized trial, we sho ...	2004	15591013
a multi-institutional survey of the effectiveness of chemotherapy combined with radiotherapy for patients with nasopharyngeal carcinoma.	previous randomized trials have shown a survival advantage of concurrent platinum-based chemoradiotherapy with or without adjuvant chemotherapy for advanced nasopharyngeal cancer. applicability of these data to a japanese population is an important issue which remains to be solved.	2004	15591454
phase ii study of cisplatin and 5-fluorouracil with concurrent radiotherapy in advanced squamous cell carcinoma of the esophagus: a japan esophageal oncology group (jeog)/japan clinical oncology group trial (jcog9516).	in japan, concurrent chemoradiotherapy is the standard treatment for unresectable esophageal cancer. the optimal combination of chemotherapeutic agents and radiotherapy dose remains controversial. the present study consists of a phase ii trial of a cisplatin (cddp)/5-fluorouracil (5-fu) infusion with concurrent radiotherapy in patients with unresectable, advanced esophageal cancer.	2004	15591460
increased plasma mmp-2 protein expression in lymph node-positive patients with colorectal cancer.	degradation of the extracellular matrix plays an important part during the invasion of cancer cells into the surrounding tissue. the matrix metalloproteinases (mmps) have a central role in this process as demonstrated in different malignancies. the aim of this study was to investigate the presence of several mmps from tumour, adjacent tumour-free colon segment and from plasma, in order to evaluate how these factors might be used as predictors in colorectal malignancy.	2004	15592677
interstitial high-dose-rate brachytherapy in the treatment of base of tongue carcinoma.	. to date none of the studies examined the feasibility and efficacy of interstitial high-dose-rate (hdr) brachytherapy in the treatment of carcinoma of the tongue base. therefore the aim of this study was to contribute to this issue.	2004	15592696
changes in thyroxine, 3,3',5-triiodothyronine and 3,3'5'-triiodothyronine content in the thyroid gland and in serum to thyroid tissue iodothyronine ratios during ontogenesis in the fetal pig.	the concentrations of thyroxine (t4), 3,3',5-triiodothyronine (t3) and 3,3',5'-triiodothyronine (reverse t3; rt3) in thyroid gland tissue and serum of the fetal pig (n = 68) from day 39 to 113 of gestation were measured. tracer quantities of iodothyronines, displaying the onset of thyroid hormone activity, were found in the thyroid tissue on day 39, i.e. before the appearance of a measurable quantity of iodothyronines in the serum. the t4 and t3 thyroidal content showed the first rise between da ...	2004	15595272
hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent pcb toxicity.	polychlorinated biphenyls (pcbs) and their hydroxylated metabolites (oh-pcbs) are known to bind to transthyretin (ttr) in vitro, possibly explaining their bioaccumulation, rodent toxicity, and presumed human toxicity. herein, we show that several oh-pcbs bind selectively to ttr in blood plasma; however, only one of the pcbs tested binds ttr in plasma. some of the oh-pcbs displace thyroid hormone (t4) from ttr, rationalizing the toxicity observed in rodents, where ttr is the major t4 transporter. ...	2004	15610856
a review of the "mysterious" wasting disease in swedish moose (alces alces l.) related to molybdenosis and disturbances in copper metabolism.	the main purpose of this article is to review the previously published data on so-called "moose sickness" in the light of two case studies presented here. molybdenosis and mo-induced disturbances of cu metabolism in moose are characterized by numerous severe lesions caused by reduced activity of cu-containing enzymes such as ceruloplasmin, superoxide dismutase in blood, and myocardial cytochrome c oxidase. consequences of such metabolic disturbances (e.g. glucose intolerance, insulin resistance, ...	2004	15621935
mass casualty management for radiological and nuclear incidents.	the decisions required for the provision of an appropriate medical response to a radiological or nuclear incident range from the traditional major incident response through to a compromised response due to a catastrophic event. a summary of the most likely clinical findings in the first 12-24 hours is given in table 4. from these findings, appropriate management based upon the needs and available resources can be planned. this includes triage for surgery and the use of the expectant (t4) triage ...	2004	15615108
the effects of hypothyroidism on nerve growth factor and norepinephrine concentrations in weight-bearing and non-weight-bearing bones of rats.	thyroid hormones affect bone remodelling directly via receptors in osteoblasts. previously, however, we have shown that the euthyroid and hyperthyroid states significantly influence the concentrations of both nerve growth factor (ngf) and norepinephrine (ne) in particular bones. both ngf and ne directly affect bone metabolism and therefore it is possible that thyroid hormone action on bone may also be indirect via its actions on these two neural-related substances. in light of previous studies, ...	2004	15615500
maximizing muscle force via low-cadence functional electrical stimulation cycling.	this study investigated the effect of pedal cadence upon torque production, power output and muscle fatigue rates during functional electrical stimulation evoked cycling in spinal cord injured individuals.	2004	15626164
molecular architecture of bacteriophage t4.	in studying bacteriophage t4--one of the basic models of molecular biology for several decades--there has come a renaissance, and this virus is now actively used as object of structural biology. the structures of six proteins of the phage particle have recently been determined at atomic resolution by x-ray crystallography. three-dimensional reconstruction of the infection device--one of the most complex multiprotein components--has been developed on the basis of cryo-electron microscopy images. ...	2004	15627372
diversity of structure and function of dna polymerase (gp43) of t4-related bacteriophages.	the replication dna polymerase (gp43) of the bacteriophage t4 is a member of the pol b family of dna polymerases, which are found in all divisions of life in the biosphere. the enzyme is a modularly organized protein that has several activities in one polypeptide chain (approximately 900 amino acid residues). these include two catalytic functions, pol (polymerase) and exo (3 -exonuclease), and specific binding activities to dna, the mrna for gp43, deoxyribonucleotides (dntps), and other t4 repli ...	2004	15627374
the effects of a short-term increase in supplementation on the reproduction performance in lactating crossbred dairy cows.	the hypothesis that dairy cows partially suckling their calves would ovulate following removal of calves when restored to positive energy balance by a short-term increase in supplementation was investigated in 65 crossbred cows. five treatments (t1, t2, t3, t4, and t5) that differed in the amount of total concentrate fed from calving to week 24 were involved. calves were allowed to suck residual milk to 12 weeks of age. energy balance was estimated by measuring intake, milk yield and organic mat ...	2004	15643813
effect of prenatal or perinatal nicotine exposure on neonatal thyroid status and offspring growth in rats.	smoking during pregnancy causes intrauterine growth retardation and low birth weight of the offspring. however, it is unclear whether nicotine, rather than other compounds from a cigarette, would mediate long-term growth retardation. there is a body of evidence suggesting that optimal thyroid status is important for the normal development of the fetus. therefore, these studies examined whether developmental nicotine exposure would interfere with the growth of the offspring and alter the thyroid ...	2004	15642595
changes in olfactory inputs modify the energy balance response to short days in male gray mouse lemurs.	the role of olfaction/olfactory cues on photoperiodic responses was assessed in malagasy primate, the gray mouse lemur. when exposed to short photoperiod (sp), this primate demonstrates rapid changes in energy balance as adaptive anticipatory response for winter survival. to follow early changes induced by sp exposure, body mass, food intake, resting metabolism (rmr) and free thyroxin levels in plasma (t4) were measured in males abruptly transferred to sp: six intact males (controls), eight male ...	2004	15642603
[inactivation of t4 phage in water environment using proteinase].	the inactivation effectiveness of proteinase to viruses was investigated by using t4 phage as a model virus. the results showed that the inactivation effectiveness of proteinase to t4 phage was obvious. in the optimum conditions and 67.5 u/ml concentration, the inactivation rate of proteinase k to t4 phage in sterilized water and in sewage achieved 99.4% and 49.4% respectively in an hour, and achieved >99.9% and 81.1% in three hours. the inactivation rate of the industrial proteinase 1398 to t4 ...	2004	15623031
hypothyroidism is common in turner syndrome: results of a five-year follow-up.	turner syndrome (ts) is caused by a sex chromosome aberration. the aim was to study the prevalence and incidence of thyroid disease in adults with ts. women with ts (n = 91; mean age, 37.7 +/- 11 yr) were compared with an age-matched female random population sample (n = 228). at baseline, 15 (16%) ts women were treated for hypothyroidism, and elevated serum tsh was found in another eight (9%). as a result, hypothyroidism was more common in women with ts (25%) than in controls (2%; p < 0.0001). s ...	2004	15623818
clinical features of type 1 diabetic children at initial diagnosis.	clinical and laboratory data of 165 newly diagnosed diabetic children at chang gung children's hospital in taiwan from 1993 to 2003 were analyzed. the age distribution was categorized as 0-1 years: 19 (11.5%), 2-4 years: 39 (23.6%), 5-9 years: 61 (37%), and 10-16 years: 46 (27.9%); the incidence showed spring/winter peak and a mid-summer trough but not statistically significant (chi2= 1.86, p=0.61). the most common symptoms on presentation were polydipsia, weight loss, polyuria, and fatigue. ver ...	2004	15624368
[surgical treatment of early adenocarcinoma arising in barrett's oesophagus].	endoscopy with biopsy, endoscopic ultrasonography and computed tomography (ct) are prerequisites for an exact preoperative staging of patients with oesophageal cancer. diagnosing an early adenocarcinoma limited to the mucosa (pt1m), the risk of lymph node metastase is nearly zero. therefore, consideration could be given to ablate endoscopically the metaplastic mucosa including the pt1m-area. on the other hand, an adenocarcinoma that is invading into the submucosa (ptlsm) has an 18 to 50% likelih ...	2004	15630987
prevalence and pattern of sick euthyroid syndrome in acute and chronic non-thyroidal illness--its relationship with severity and outcome of the disorder.	non-thyroidal illness is a common cause of alterations in thyroid hormone economy in absence of underlying intrinsic thyroid disorder.	2004	15633715
[prostate cancer diagnosed before 55: a retrospective study from the rare cancer network].	this retrospective study on a large number of cases offers a vision of the modalities of care in prostate cancer diagnosed before the age of 55, according to different policies, aiming to propose other directions for 2005. between january 1974 and december 2001, 365 patients had a pathological diagnosis of prostate cancer occurring before the age of 55. these patients were referred to the departments of radiation therapy affiliated to the rare cancer network. a questionnaire was filled in retros ...	2004	15634636
the effect of a thyroid hormone infusion on vasopressor support in critically ill children with cessation of neurologic function.	to determine the impact of a thyroid hormone infusion (t4) on the vasopressor requirements in children with cessation of neurologic function (i.e., brain death) during evaluation for organ recovery	2004	15640648
[blood profile of hypothyroid castrated or intact adult female rats].	the relationship between thyroid-gonads on the blood profile was investigated in adult wistar female rats. these animals were either castrated or intact and were kept under hypothyroidism, induced by daily administration of propylthiouracil (ptu) during 120 days. two groups (castrated and intact) were kept in an euthyroid condition and used as controls. it was collected plasma for free t4 dosage and blood for hematological analysis. the significant low values of free t4 in the treated rats confi ...	2004	15640885
[usefulness of radioiodine scanning in patients with moderate/high risk differentiated thyroid carcinoma in whom thyroglobulin after thyroxin withdrawal is undetectable after initial treatment].	we selected 92 patients without antithyroglobulin antibodies (tgab), in whom thyroglobulin (tg) after l-thyroxin withdrawal was undetectable (<1 ng/ml) 6-12 months after initial therapy and who were considered to be at moderate / high risk for recurrence by this criteria: age >45 years; tumor size >1.5 cm; and lymph nodes metastases in 43 (46.7%), local invasion in 26 (28.2%) or distant metastases in 23 (25%). control whole-body scanning was negative in 78.2% of the cases and showed cervical upt ...	2004	15640901
breast cancer and neoadjuvant therapy: any predictive marker?	the majority of patients with breast carcinoma receive chemotherapy as a component of multimodality treatment. over the past decade, it has become increasingly more common to deliver chemotherapy first, but this has raised new questions within all disciplines of cancer management. however, the effect of cytotoxic treatment cannot be predicted on individually specific basis, then identification of tumor characteristics associated with tumor therapeutic response and outcome is then of great clinic ...	2004	15640958
subtotal thyroidectomy with transposition of the remnant gland to the subcutaneous space. a new alternative technique in benign thyroid disease.	thyroidectomy is the preferred surgical option for the treatment of benign disease of the thyroid in a wide rage of indications. controversy exists concerning the extent of the primary excision for optimal results. a subtotal thyroidectomy with transposition of the thyroid remnant to the subcutaneous space prevents thyroid hormone supplementation for life and laryngeal nerve damage during a re-operation.	2004	15663283
qtc interval and qtc dispersion during haemodiafiltration.	background and	2004	15663633
developmental hormonal profiles in rdw rats with congenital hypothyroidism accompanying increased testicular size and infertility in adulthood.	congenital hypothyroid mutant male rdw rats have enlarged testes in adulthood with dwarfism accompanied by infertility. to explain how rdw rats acquire enlarged testes in adulthood, we compared age-matched normal (n) rats at various developmental stages for blood levels of hormones, thyroxine (t4), follicle stimulating hormone (fsh), luteinizing hormone (lh) and testosterone (t), and investigated whether t4 therapy (rdw+t4) from 3 weeks of age (w) until adulthood could induce recovery of fertili ...	2004	15647620
the thyroid hormone receptor beta-specific agonist gc-1 selectively affects the bone development of hypothyroid rats.	we investigated the effects of gc-1, a trbeta-selective thyromimetic, on bone development of hypothyroid rats. whereas t3 reverted the igf-i deficiency and the skeletal defects caused by hypothyroidism, gc-1 had no effect on serum igf-i or on igf-i protein expression in the epiphyseal growth plate of the femur, but induced selective effects on bone development. our findings indicate that t3 exerts some essential effects on bone development that are mediated by trbeta1.	2004	15647824
the management of peritoneal surface malignancy of colorectal cancer origin.	colorectal carcinomas are predominantly spread malignancies. peritoneal carcinomatosis frequently associates colorectal carcinomas. the tumour grade, the completeness of cytoreduction, the tumour volume, the presence of distant metastases, prior surgery score and the extent of peritoneal implantations are prognostic clinical features of survival. the management of colorectal cancer with peritoneal carcinomatosis is possible by resection of tumour, cytoreduction and intraperitoneal chemotherapy. ...	2004	15655638
clinical usefulness of a long-term treatment with an antithyroid drug for psoriasis vulgaris.	we have previously reported that an antithyroid thiourethylene, thiamazole, can bring about significant clinical improvement in patients with psoriasis vulgaris. although the efficacy of antithyroid thiourethylenes had been reported earlier, few studies have evaluated the safety of its long-term use. in this study, we aimed to study whether or not long-term thiamazole administration is complicated by any adverse effects. eight patients with psoriasis vulgaris were enrolled in this study after in ...	2004	15672705
developmental disruption of thyroid hormone: correlations with hearing dysfunction in rats.	a wide variety of environmental contaminants adversely affect thyroid hormone (th) homeostasis. hypothyroidism and/or hypothyroxinemia during the early postnatal period in the rat leads to permanent structural damage and loss of function in the cochlea. a major uncertainty in assessing the risks of developmental exposure to thyroid-disrupting chemicals (tdcs) is the lack of a clear characterization of the dose-response relationship, especially in the lower region, between disruption of hormones ...	2004	15660619
massage treatment in hiv-1 infected dominican children: a preliminary report on the efficacy of massage therapy to preserve the immune system in children without antiretroviral medication.	more than 1.4 million children are living with hiv and global access to antiretrovirals is not yet readily available. massage therapy, which has been shown to improve immune function in hiv+ adults and adolescents, may provide an important complementary treatment to boost immune status in young children living with hiv disease, especially those without access to antiretroviral medications. no studies have been conducted, however, that specifically target massage therapy to enhance immune functio ...	2004	15674006
does substitution of t4 with t3 plus t4 for t4 replacement improve depressive symptoms in patients with hypothyroidism?	substitution of t4 with t3 for t4 replacement in patients with hypothyroidism was undertaken using a randomized placebo controlled study design. forty individuals were included who had depressive symptoms on stable doses of levothyroxine. combined t4 plus t3 did not have a significantly different effect on mood and well-being scores than did t4 alone.	2004	15677430
laparoscopic radical prostatectomy after neoadjuvant hormonal therapy: an apparently safe and effective procedure.	in an effort to determine the safety and efficacy of laparoscopic radical prostatectomy (lrp) in patients who have received neoadjuvant hormonal therapy (nht), our initial series of 65 patients undergoing successful lrp was analyzed, specifically comparing 5 patients who received neoadjuvant hormonal therapy to 60 who did not.	2004	15684777
combined-modality therapy of rectal cancer with irinotecan-based regimens.	there are two conventional treatments for clinically resectable rectal cancer. the first is surgery followed by postoperative combined-modality therapy if the tumor is t3 and/or n1/2. the second, if the tumor is ultrasound t3 or clinical t4, is preoperative combined-modality therapy followed by surgery and postoperative chemotherapy. there are a number of new chemotherapeutic agents that have been developed for the treatment of colorectal cancer. phase i/ii trials are examining the use of new ch ...	2004	15685836
irreversible and reversible adhesion between virus particles and hydrolyzing-precipitating aluminium: a function of coagulation.	the infectivity of viruses (qbeta, ms2, t4, and p1) after dosing virus-contaminated water with 4 types of aluminium coagulant was investigated. the concentrations of infectious viruses were determined after dissolving aluminium hydroxide flocs in alkaline solution. the concentration of infectious viruses did not recover to the initial value after a short floc-dissolution time (5 s). although the infectious virus concentration increased as the floc-dissolution time was extended to 5 h, it did not ...	2004	15686022
[preliminary results of thyroid function assessment in children and adolescents with hodgkin's disease (hd) treated according to pgp-hd-97 protocol].	the intensive treatment of hd (multidrug chemotherapy combined with radiotherapy) carries the risk of early and late complications. one of the late effects is thyroid dysfunction which may occur after radiotherapy of the cervical region. in this report preliminary results of thyroid function assessment in children with hd in correlation with time after cessation of therapy are presented. between january 1, 1997 and december 31, 2002, 58 children with hd (age: 2.6-18.3 years, median, 14.9 years) ...	2004	15686053