Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| hormono-radiotherapy in prostatic carcinoma: prognostic factors and implications for combined modality treatment. | the aim of this study was to evaluate the prognostic role of several clinical variables in a patient population undergoing neoadjuvant hormonotherapy (nht) with external beam radiotherapy (ert) to identify subsets of patients with an unfavorable prognosis who require intensified therapy. eighty-four patients (mean age, 68.2 +/- 6.1 years; range, 52-81 years) underwent ert (45 gy to pelvic volume; 65 gy mean dose to prostate volume) and nht (oral flutamide: 250 mg three times daily for 30 days; l ... | 2002 | 12597145 |
| postoperative irradiation in localized renal cell carcinoma: the rambam medical center experience. | this study evaluated the results of postoperative adjuvant radiotherapy in patients with localized renal cell carcinoma (rcc). | 2002 | 12597146 |
| central nervous system lipomas. | the lipomas of the central nervous system are rare lesions of congenital origin and are located in the medial line and especially in corpus callosum. intramedullary spinal lipomas can be seen in the life span of 30 years of age and most frequently coincide with initial puberty period. magnetic resonance imaging and computerized tomography together with clinical trials are of crucial importance for diagnosis. the first case: a two-year-aged girl who had lipoma in quadrigeminal cistern and who suf ... | 2002 | 12597248 |
| locoregional recurrence of breast cancer: a retrospective comparison of treatment methods. | the study was made to evaluate the clinical and pathological features of breast cancer patients with locally recurrent breast cancer and to assess the impact of the treatment method on their prognosis. fifty-four patients with local recurrence after breast cancer were treated in greatpoland cancer center between 1983 and 1995. it constituted 6.2% (54/878) of all patients with breast cancer treated in this period. median length of interval between primary lesion and recurrence was 26.6 months, in ... | 2002 | 12584593 |
| prospective comparison of endoscopy, endosonography and computed tomography for staging of tumours of the oesophagus and gastric cardia. | local and multimodal therapeutic strategies for tumours of the oesophagus and gastric cardia, require precise preoperative staging. endosonography is considered the most accurate staging method, while computed tomography (ct) has limitations especially in the evaluation of local infiltration. macroscopic endoscopic evaluation was reported to be accurate in selected series, but no study has yet compared all three staging modalities. | 2002 | 12592099 |
| [effects of chlorotriptolide and triptonide on chromosome aberration and micronuclei of bone marrow cell in male rats]. | to observe the effects of chlorotriptolide (t4) and triptonide (t7) on the chromosome aberration and micronuclei rates of bone marrow cell in male sd rats. | 2002 | 12593012 |
| [the functional status of some endocrine glands in children with enzymopathy of the small intestine]. | as many as 53 children with enzymopathies of the small intestine aged 9 months-14 years were examined. of these, 25 had celiac disease, 27 presenting with gee-herter syndrome. in all patients, there have been studied patterns of hydrocortisone, thyroid hormones, thyrotrophin, insulin. ascertained in the above pathology was a decline in the functional activity of the hypophysis, thyroid gland, adrenals, insular apparatus. the degree of the hormonal inadequcy has been found to be related to the fo ... | 2002 | 12587309 |
| [autotransplantation of the spleen]. | auto transplantation of the spleen can be performed in the patients with traumatic rupture of the spleen, in whom spleen could not be conserved in the other way. the right indication for this method is isolated rupture of the spleen (concvasation or complete devascularisation). this method is not recommended in the endangered patients, patients with previous disease of the spleen as well as in the patients with the perforation of the other abdominal organs at the same time. auto transplantation ... | 2002 | 12587457 |
| [carcinoma of the anal canal--results of radical radiotherapy]. | from february 1995 to august 2001, 34 pts with squamous cell carcinoma of the anal canal (stage t2-35.3%, stage t3-44.1%, stage t4-20.6%, stage n1-29.4%) were treated prospectively by definitive radiotherapy only, delivered with megavoltage linear accelerator, combined with intracavitary brachytherapy in some patients, at the institute for oncology and radiology of serbia. total tumor dose was range 55-75 gy. median follow-up time was 24.7 mounts (range 6-66 mounts). overall survival and disease ... | 2002 | 12587476 |
| effect of antioxidants (vitamin c, e and turmeric extract) on methimazole induced hypothyroidism in rats. | the study was to investigate the protective effect of antioxidants against methimazole (mmi) induced hypothyroidism in rats. male wistar rats were fed mmi, mmi plus vitamin c, mmi plus vitamin e and mmi plus turmeric extract (te) supplemented diet. at the end of the experiments, thyroid weights, thyroxine (t4), triiodothyronine (t3) and cholesterol levels were determined. it was observed that mmi treated rats showed increase in thyroid weights, very low levels of circulating t4, t3 and increased ... | 2002 | 12587721 |
| the prediction of height by armspan in older chinese people. | to compare the accuracy of the predictive equations derived from older chinese people without vertebral deformity with those derived from unselected older people, in estimating height from armspan. | 2002 | 12573081 |
| [protective effect of tripchlorolide on dopaminergic neurons in partially lesioned rat model of parkinson's disease]. | to study whether the immunosuppressant tripchlorolide (t4) exerts neuroprotective effect on dopaminergic neurons. | 2002 | 12579836 |
| [hypothyroidism in children. 82 cases]. | the hypothyroidism is a frequent endocrinopathos. the authors report a retrospective study of 67 cases gathered at pediatric department of sfax, during 23 years. 40 boys and 42 girls aged from 1 to 164 months, with an average of 55 months old children. the most clinical symptoms have been the dysmorphic syndrome (81.17%), huge tongue (59.75%), the t3 is low in 30.48%, the ft4 or the t4 is low in 79% and the tsh is high in 84.14%. all the patients have benefitted a treatment based on thyroidian e ... | 2002 | 12664514 |
| fish arsenic may influence human blood arsenic, selenium, and t4:t3 ratio. | the effects of an arsenic-rich fish diet and selenium (se) supplementation on blood arsenic (as), se, and thyroid hormones were studied in 32 women divided into four equal groups. groups 1 and 4 received 400 microg se-methionine daily, group 2 received 400 microg selenite daily, and group 3 received placebo tablets for 15 wk. in addition, groups 1-3 increased their fish intake, eating at least three fish dinners weekly. mean blood se concentrations (initially 1.68 +/- 0.24 micromol/l) increased ... | 2002 | 12666828 |
| [supracricoid subtotal laryngectomy with laryngeal reconstruction for laryngeal cancers]. | to assess the effectiveness of supracricoid subtotal laryngectomy in the treatment of laryngeal cancer and the reconstructed laryngeal functions. | 2002 | 12669435 |
| [effect of erythropoietin on thyroid function in patients on hemodialysis]. | chronical renal insufficiency is followed by many endocrinological abnormalities which pathogenesis isn't still enough clarified. the hormone level of thyroid gland is often abnormal. it is well known that use of erythropoietin leeds to an improvement of the various endocrine disorders. the aim of this paper was to evaluate the erythropoetin impact on the thyroid function in patients on haemodialysis. | 2002 | 12693323 |
| intramedullary epidermoid cyst: preoperative diagnosis and surgical management after mri introduction. case report and updating of the literature. | many patients with spinal tumours of developmental origin do not receive preoperative diagnosis and the surgical management, especially as for capsule resection, is often unplanned. like other uncommon tumours, the intramedullary epidermoid cyst is often an operative or histological finding. since magnetic resonance imaging (mri) introduction, evidence has accumulated that they may be preoperatively suspected. in reporting the case of a young patient with a t3-t4 intramedullary epidermoid cyst, ... | 2002 | 12690335 |
| serum thyroxine concentrations and pregnancy rates 15 to 16 days after ovulation in broodmares. | to determine whether serum thyroxine (t4) concentration was associated with pregnancy rates 15 to 16 days after ovulation in mares and to determine whether thyroid hormone supplementation would enhance fertility in mares. | 2002 | 12680450 |
| [multivariate analysis of risk factors associated with dehiscence of colorectal anastomosis after anterior or lower anterior resection for sigmoid or rectal cancer]. | clinical anastomotic leakage remains a major problem after anterior or low anterior resection for rectal or sigmoid cancer. | 2002 | 12685217 |
| [ilio-pelvic lymphatic dissection in the rectal cancer]. | the method of iliopelvic lymphodissection was used in 61 patients aged from 42 to 72 years having histologically verified rectum cancer. the results of treatment by this method have shown that in 83.6% of the patients the tumor spread corresponded to pt3-t4, the metastatic involvement of regional lymph nodes was found in 52.5% of the patients. the most justified reason for a radical surgery and lymphodissection was a combination of the endoscopic signs of a considerable extension of the tumor ar ... | 2002 | 12661247 |
| subacute thyroiditis as seen initially in ent department--a report of 30 cases. | to assess the pharyngeal presentations and the diagnostic value of thyroid spect and thyroid fine needle aspiratory biopsy (fnab) in subacute thyroiditis (sat) as seen initially in ent department, 30 patients, during the course of sat, were examined for pharyngeal symptoms and tested for serum t3, t4 level. the thyroid spect imaging or thyroid fnab were performed. our results showed that, of the 30 patients, 21 had sore throat of various degrees, and 9 had abnormal sensation of throat. six were ... | 2002 | 12658793 |
| helical ct evaluation in the preoperative staging of gastric adenocarcinoma. | the aim of this study is to evaluate helical ct as a basic preoperative test for the staging of gastric adenocarcinoma. | 2002 | 12647409 |
| [treatment in psychiatric day hospital in comparison with inpatient wards in different european health care systems--objectives of eden project]. | the paper presents the objectives and design of an ongoing multicenter randomized, controlled trial eden (european day hospital evaluation). the eden-study aims to evaluate the efficacy of acute psychiatric treatment in a day hospital setting in five european centres: dresden, london, michalovce, prague and wroclaw. the main hypothesis is that day hospital treatment for acute psychiatric patients is as effective as conventional inpatient hospital care. the objectives of the study are to evaluate ... | 2002 | 12647460 |
| thyroid and infertility. | infertility is defined as the inability to conceive after one year of regular intercourse without contraception. the prevalence of infertility is estimated between 12 and 14% and remains stable in recent years. it thus represents a common condition, with important medical, economic and psychological implications. according to a standard protocol infertility evaluation usually identifies different causes, including, male infertility (30%), female infertility (35%), the combination of both (20%), ... | 2002 | 12649931 |
| [extracolonic manifestation as first sign of colorectal carcinoma. report of 2 cases]. | in mexico, colorectal cancer is the second most common malignant tumor of digestive tract; incidence is proportional to patient age. at time of diagnosis, 20% of patients can be found with metastases, liver and lung the organs affected most frequently. | 2002 | 12653074 |
| matrix is the site of indirect effects of propranolol on the ion channelopathies in cardiac remodeling by l-thyroxine. | cardiac remodeling by chronic l-thyroxine medication causes exaggerated cardiac arrhythmias in relation to ion channelopathies that involve multichannels. the matrix of lipid membrane is likely the key site where channel lesions, possibly will develop and be benefitted by drug intervention. cardiac remodeling in rats and guinea pigs was developed by l-thyroxine 0.5 mg/kg sc for 10 days. propranolol was instituted on days 8-10. whole cell holding was applied to measure ion currents. an increase i ... | 2002 | 12630546 |
| correlation of radiographic, clinical, and patient assessment of shoulder balance following fusion versus nonfusion of the proximal thoracic curve in adolescent idiopathic scoliosis. | retrospective clinical, radiographic, and patient outcome review of surgically treated adolescent idiopathic scoliosis. | 2002 | 12634561 |
| targeted proteomics of low-level proteins in human plasma by lc/msn: using human growth hormone as a model system. | this paper describes the profiling of human growth hormone (hgh) in human plasma in order to assess the dynamic range of the ion-trap mass spectrometer for proteomic studies of complex biological samples. human growth hormone is an example of a low-level plasma protein in vivo, present at subfemtomole levels. this study was performed on a plasma sample in which hgh has been spiked at 10-fold above the natural level, that is approximately 16 pg/microl of plasma. initially, the measurement was car ... | 2002 | 12645918 |
| affinity precipitation separation of dna binding protein using block conjugate composed of poly(n-isopropylacrylamide) grafted double-stranded dna and double-stranded dna containing a target sequence. | in this research, we synthesized a novel dna-polymer conjugate and evaluated its application to an affinity precipitation separation of tata-box binding protein (tbp), which is a representative general transcription factor. the conjugate was composed of two fractions. one was a double-stranded dna modified by the grafting of poly(n-isopropylacrylamide) (pnipaam), which is known as a thermosensitive vinyl polymer. the other fraction is a native double-stranded dna containing a specific base seque ... | 2002 | 12502078 |
| purification of histidine-tagged t4 rna ligase from e. coli. | here we report the construction of a histidine-tagged t4 rna ligase expression plasmid (prht4). the construct, when overexpressed in bl21 (de3) cells, allows the preparation of large quantities of t4 rna ligase in high purity using only a single purification column. the histidine affinity tag does not inhibit enzyme function, and we were able to purify 1-3 mg pure protein/g cell pellet. a simple purification procedure ensures that the enzyme is de-adenylated to levels comparable to those found f ... | 2002 | 12503310 |
| thyroid dysfunction and high thyroid stimulating hormone levels in children with down's syndrome. | in order to delineate the spectrum of thyroid abnormalities in children with down's syndrome (ds), first visit height data (sds) and serum tsh, t4 and antiperoxidase antibodies concentrations were retrospectively evaluated in 137 children (71 girls) with ds (0.04-16 years). results: congenital hypothyroidism was detected in 2.9% of patients. thyroid disease occurred in 9%: four hyperthyroidism and eight hypothyroidism. overt thyroid disease was always related to thyroid autoimmunity. the remaini ... | 2002 | 12503863 |
| somatotrophic and thyroid hormones around the onset of lay in broiler breeders under different conditions. | somatotrophic and thyroid hormones were determined around the onset of reproduction in broiler breeders reared in two different housing systems [dark, close-sided house (ch) and conventional, open-sided house (oh)]. in both groups age-related changes were obvious for thyroxine (t4), growth hormone (gh) and insulin-like growth factor (igf-1); levels of t4 decreased, especially between 24 and 28 weeks in both groups; concomitantly gh sharply increased over the same period. a transient peak in trii ... | 2002 | 12498147 |
| low recurrence rate of hepatocellular carcinoma after liver transplantation: better patient selection or lower immunosuppression? | liver transplantation is currently offered to a limited number of patients with hepatocellular carcinoma (hcc) because of strict criteria introduced in the past to avoid recurrence. immunosuppression represents a risk factor for tumor growth; the schedules of the immunosuppressant drugs have been modified through the years, aiming to reduce their dosage to the effective minimum. | 2002 | 12499891 |
| [molecular genetic progression on nasopharyngeal carcinoma]. | the aim of this paper was to discuss the molecular genetic events in the development and progression of nasopharyngeal carcinoma (npc), and the correlation between genetic alterations and clinicopathological changes of npc. analyzed by loh (loss of heterozygosity) and cgh (comparative genomic hybridization) in primary npc, high frequent allelic losses were observed on chromosomes 1p, 3p, 9p, 9q, 11q, 13q, 14q, 16q, and 19q, and the minimum deletion regions were also localized; there are closely ... | 2002 | 12500388 |
| distribution of vascular endothelial growth factor (vegf) in prostate disease. | vascular endothelial growth factor (vegf) is a heparin-binding polypeptide growth factor. it is a potent mitogen for endothelial cells. immunohistochemical localisation of vegf was performed on 25 moderate to poorly differentiated stage t4 m+ prostate cancer specimens and 30 benign prostatic hyperplasia (bph) specimens. a positive result was indicated by area staining >25% and +2 or +3 staining intensity. positive epithelial staining was observed in 50% of bph specimens and 56% of cancer specime ... | 2002 | 12497000 |
| pre- and postprandial changes in plasma hormone and metabolite levels and hepatic deiodinase activities in meal-fed broiler chickens. | the present study aimed to study the effects of food deprivation and subsequent postprandial changes in plasma somatotrophic and thyrotrophic hormone levels and focused on the inter-relationships between these hormonal axes and representative metabolites of the intermediary metabolism of meal-fed broiler chickens. male broiler chickens (2 weeks old) were fed a meal of 40-45 g/bird per d for two consecutive weeks (food-restricted (fr) treatment). the daily allowance was consumed in about 30 min. ... | 2002 | 12493086 |
| using t4 dna polymerase to generate clonable pcr products. | 2002 | 12494644 | |
| [preoperative diclofenac does not reduce pain of laparoscopic cholecystectomy]. | to study the safety and efficacy of diclofenac for preemptive analgesia in the first 24 hours after elective laparoscopic cholecystectomy (elc). | 2002 | 12516489 |
| t3-t4 disc herniation in a german shepherd dog. | 2002 | 12521251 | |
| quality of life 2-10 years after combined treatment for advanced oral and oropharyngeal cancer. | this study reports the findings of an evaluation of quality of life (qol) in long-term survivors of advanced oral and oropharyngeal cancer treated with preoperative chemoradiotherapy followed by surgery (combined treatment=multimodal therapy). all patients had t2-t4 tumours and all received locoregional radical resection and simultaneous microvascular reconstruction. from 1990 to 1998, 181 patients have been treated at the university hospital of cranio-maxillofacial and oral surgery in vienna. 1 ... | 2002 | 12521326 |
| [glia-like brain tumors. potential role of thyroid hormone and its nuclear receptors (tr)]. | over-proliferation of certain cells lead to tumor formation and therefore impairments of regulation of the cell cycle are inalienable and basic signs of neoplasms. the majority of known oncogenes and tumor suppressors are components of a few common signaling pathways that control the cell cycle, genome integrity, cell differentiation and apoptosis. changes in these signaling pathways cause the development of tumor genesis. the thyroid hormones (3, 5, 3'-l-triiodothyronine, t3; 3, 5, 3', 5'-l tet ... | 2002 | 12523122 |
| thyrotropin-secreting pituitary adenoma with growth hormone hypersecretion. | a 34-year-old woman suffered from palpitation, easy sweating, heat intolerance, increased appetite, irregular menstrual cycle and hand tremor for 1 year. thyroid function tests showed elevated serum thyroxine (t4), tri-iodothyronine (t3) and thyrotropin (tsh). computerized tomography (ct) revealed pituitary tumor with supraseller extension. thyrotropin releasing hormone (trh) test showed blunted tsh response with elevated baseline level and paradoxical growth hormone (gh) response with elevated ... | 2002 | 12523814 |
| effects of short-term trimethoprim-sulfamethoxazole administration on thyroid function in dogs. | to determine how rapidly trimethoprim-sulfamethoxazole affects serum total thyroxine (t4) and thyroid-stimulating hormone (tsh) concentrations in euthyroid dogs and how quickly hormone concentrations return to reference values following discontinuation of administration. | 2002 | 12322917 |
| thyrotropin screening for congenital hypothyroidism in queen sirikit national institute of child health, thailand (during year 1995-2000). | to detect newborns with congenital hypothyroidism (ch) by tsh screening and to treat the affected infants as early as possible. to find the incidence of ch in neonates born at rajavithi hospital from 1995 to 2000. the effects of thyroid pathology, ages at the initiation of treatment, associated conditions, and severity of ch on the intellectual outcome of the patients were also analyzed. | 2002 | 12296410 |
| hypothalamic gene expression in reproductively photoresponsive and photorefractory siberian hamsters. | an interval timing mechanism in the brain governs reproduction in seasonally breeding mammals by triggering refractoriness to inhibitory short photoperiods during midwinter. the neural mechanisms responsible for the timing and induction of photorefractoriness by this seasonal clock are unknown. using cdna microarrays and rt-pcr, we identified a class of genes encoding thyroxine (t4)-binding proteins (transthyretin, t4-binding globulin, albumin) whose expression is associated with reproductive re ... | 2002 | 12456888 |
| circle ligation of in vitro assembled chromatin indicates a highly flexible structure. | evidence is provided that some condensed linker histone-containing chromatin structures are highly flexible in solutions containing 2 mm mg2+. chromatin assembled in vitro +/- histone h5 on a 6.3 kb linear dna fragment in 90 mm nacl using the polyglutamic acid method sedimented fairly homogeneously. the h5-containing sample had s(20, w) values that were 58-69% greater than the sample lacking h5. chromatin assembled on linear puc19 plasmid dna was treated with t4 dna ligase in solutions containin ... | 2002 | 12466533 |
| comparison of clinical and surgical-pathologic staging of the patients with non-small cell lung carcinoma. | clinical staging of non-small cell lung cancer helps to determine the extent of disease and separate patients with potentially resectable disease from those that are unresectable. since, clinical staging is based on radiologic and bronchoscopic findings, overstaging or understaging may occur comparing to the final surgical-pathologic evaluation. we aimed to analyze preoperative and postoperative stagings in order to evaluate stage migrations and our surgical strategy for marginally resectable pa ... | 2002 | 12467827 |
| paraparesis in a black man brought on by ossification of the ligamentum flavum: case report and review of the literature. | we present the second case of paraparesis secondary to ossification of the ligamentum flavum at the midthoracic region in a black man. ossification of the ligamentum flavum is frequently described in the japanese population where the presentation is often in the lower thoracic region. the patient is a 37-year-old black man who, over the 6 months before admission, noticed progressive paraparesis. ct myelogram revealed severe thoracic stenosis by an ossified ligamentum flavum from t4 to t7 with mo ... | 2002 | 12468987 |
| in vitro effects of thyroid hormones on ectonucleotidase activities in synaptosomes from hippocampus of rats. | 1. studies have shown that adenosine transport and adenosine a1 receptors in rat brain are subjected to regulation by thyroid hormone levels. since the ectonucleotidase pathway is an important source of adenosine extracellular, in the present study the in vitro action of t3 and t4 hormones on ectonucleotidase activities in hippocampal synaptosomes was evaluated. 2. t3 (triiodo-l-thyronine) significantly inhibited, in an uncompetitive manner, the atp and adp hydrolysis promoted by atp diphosphohy ... | 2002 | 12469875 |
| treatment of hyperfunctioning thyroid nodules by percutaneous ethanol injection. | background: autonomous thyroid nodules can be treated by a variety of methods. we assessed the efficacy of percutaneous ethanol injection in treating autonomous thyroid nodules. methods: 35 patients diagnosed by technetium-99 scanning with hyperfunctioning nodules and suppressed sensitive tsh (stsh) were given sterile ethanol injections under ultrasound guidance. 29 patients had clinical and biochemical hyperthyroidism. the other 6 had sub-clinical hyperthyroidism with suppressed stsh levels (<0 ... | 2002 | 12470301 |
| type iv collagen, type iv collagenase activity and ability of cell proliferation in human thyroid tumours. | the processes of malignant tumour invasion and metastasis are known to include the destruction of cell stroma and vascular basement membrane. it has been suggested that type iv collagenase degrades type iv collagen, a main component of the basement membrane. | 2002 | 12471003 |
| o-galnac incorporation into a cluster acceptor site of three consecutive threonines. distinct specificity of galnac-transferase isoforms. | o-glycosylation of three consecutive thr residues in a fluorescein-conjugated peptide ptttplk - which mimics a portion of mucin 2 - by four isozymes of udp-n-acetylgalactosaminyltransferases (pp-galnac-t1, t2, t3, or t4) was investigated. partially glycosylated versions of this peptide, pt*ttplk, pttt*plk, pt*tt*plk, ptt*t*plk, pt* degrees ttplk, and pttt* degrees plk (*, n-acetylgalactosamine; degrees, galactose), were also tested. the products were separated by rp-hplc and characterized by mal ... | 2002 | 12473113 |
| excision of the levator muscles with external sphincter preservation in the treatment of selected low t4 rectal cancers. | the existence of an anatomic and functional separation between the puborectalis muscle and external anal sphincter permits the performance of an abdominoendoanal excision, instead of an abdominoperineal excision, of the rectum and levator muscles, with preservation of a functioning external sphincter, in selected patients with very low rectal cancer and limited infiltration of the levator muscles. | 2002 | 12473899 |
| insight into the physiological actions of thyroid hormone receptors from genetically modified mice. | thyroid hormones exert a range of developmental and physiological actions in all vertebrates. serum concentrations of l-thyroxine (t4) and 3,5,3 -l-triiodothyronine (t3) are maintained by a negative feedback loop involving t3-inhibition of hypothalamic thyrotrophin releasing hormone (trh) and pituitary thyroid stimulating hormone (tsh) secretion, and by tissue specific and hormone-regulated expression of the three iodothyronine deiodinase enzymes that activate or metabolise thyroid hormones. t3 ... | 2002 | 12475367 |
| is the low tri-iodothyronine state a crucial factor in determining the outcome of coronary artery bypass patients? evidence from a clinical pilot study. | the cardiovascular system is an important target for thyroid hormones. the present study evaluates the changes affecting thyroid hormone metabolism during and 6 days after coronary artery bypass and their relationship with the post-operative outcome of the patients. thirty-three patients were enrolled in the study; their thyroid hormone profiles were determined at 13 sampling points during surgery and for 6 days afterwards. serum total tri-iodothyronine (t3) and free t3 (ft3) concentrations decr ... | 2002 | 12475369 |
| influence of maternal hyperthyroidism in the rat on the expression of neuronal and astrocytic cytoskeletal proteins in fetal brain. | maternal hypothyroidism during pregnancy impairs brain function in human and rat offspring, but little is known regarding the influence of maternal hyperthyroidism on neurodevelopment. we have previously shown that the expression of neuronal and glial differentiation markers in fetal brain is compromised in hypothyroid rat dam pregnancies and have now therefore extended this investigation to hyperthyroid rat dams. study groups comprised partially thyroidectomised dams, implanted with osmotic pum ... | 2002 | 12475371 |
| continuous age-dependent reference ranges for thyroid hormones in neonates, infants, children and adolescents established using the advia centaur analyzer. | in neonates, infants, children and adolescents serum concentrations of the thyroid hormones show a clear age dependency. currently, age-dependent thyroid hormone reference ranges for the new advia centaur immunoanalyzer are not available. thyroid-stimulating hormone (tsh), free thyroxine (ft4), total thyroxine (t4), free triiodothyronine (ft3) and total triiodothyronine (t3) were determined in the sera of 460 healthy children aged 0 daysto 18 years from an inland (n=308) and a seaside city (n=15 ... | 2002 | 12476946 |
| effect of nutritional stress on the hypothalamo-pituitary-gonadal axis in the growing male rat. | nutritional dwarfing (nd) consists of a decrease in weight and height gain and delayed onset of puberty. the aim of the present investigation was to study the modifications induced in male rats by the nutritional stress of a mere 20% reduction in food intake which, however, started immediately after weaning. | 2002 | 12481155 |
| total synthesis of amphidinolide t4. | 2002 | 12481352 | |
| circulating il-8 and il-10 in euthyroid sick syndromes following bone marrow transplantation. | it is generally agreed that euthyroid sick syndromes (ess) are associated with an increased production of cytokines. however, there has been scarce data on the relationship thyroid hormone changes and cytokines among the patients undergoing bone marrow transplantation (bmt). because interleukin-8 (il-8) has been identified as a potent proinflammatory and interleukin-10 (il-10) as an antiinflammatory cytokine, we studied the relation between thyroid hormone parameters and these cytokines followin ... | 2002 | 12482997 |
| 'in vitro' binding of propofol to serum lipoproteins in thyroid dysfunction. | to determine a regression relationship between the unbound fraction (fu percent) of propofol, a highly lipophilic intravenous anaesthetic agent, and demographic and biochemical variables in a thyroid dysfunction population. | 2002 | 12483454 |
| [chemoradiotherapy using platinum analogs/5-fu for advanced esophageal cancer]. | we evaluated the efficacy of concurrent chemoradiotherapy (crt) using cisplatin/nedaplatin and 5-fu for advanced esophageal cancer. thirteen patients with locally advanced esophageal cancer (t4 cases) and 3 with recurrence of esophageal cancer were treated with radiotherapy (40-70 gy) and 5-fu combined with cisplatin/nedaplatin concurrently. t4 patients who obtained down-staging by crt also underwent esophagectomy. a complete response was obtained in one case, partial response in 8 cases, and no ... | 2002 | 12484039 |
| effects of methimazole pretreatment on cerulein induced acute pancreatitis in rats. | many interrelationships exist between the thyroid gland and the gastrointestinal tract. several past and recent studies have shown that the thyroid gland profoundly influences the structure and function of the exocrine pancreas in the rat. in the present study we investigated the effect of methimazole (metz), an antithyroid drug, on cerulein induced acute pancreatitis (ap) in rats. | 2002 | 12484556 |
| [prognostic factors in patients with primary non-hodgkin's lymphoma of the tonsil]. | to investigate the prognostic value of the size of primary tumor (t staging) and international prognostic index (ipi) for patients with non-hodgkin's lymphoma (nhl) of the tonsil, and to recommend the treatment strategy for early stage patients. | 2002 | 12485504 |
| making appdna using t4 dna ligase. | 5('),5(')-adenylyl pyrophosphoryl dna (appdna) contains a high-energy pyrophosphate linkage and can be exploited as an activated dna substrate to derive new dna enzymes for carrying out various dna modification reactions. for this reason, enzymatic synthesis of appdna is highly desirable. appdna is a known intermediate in dna ligase mediated dna ligation reactions, but rarely accumulates under normal reaction conditions. here we report that t4 dna ligase can quantitatively convert 5(')-phosphory ... | 2002 | 12485593 |
| [myxedema coma as a rare differential diagnosis of severe consciousness disturbance]. | myxedema coma is a rare and life-threatening complication of untreated hypothyroidism. therefore, it must be part of the differential diagnosis in comatose patients. we report one patient who presented with co(2) narcosis,hypothermia, bradycardia,hyporeflexia, tetraparesis, ascitis, pleural effusions, and heart insufficiency. examination of the csf, cranial ct, mri, and mr angiography were normal. in suspicion of myxedema coma,the patient was treated with high dose l-thyroxine and hydrocortisone ... | 2002 | 12486569 |
| the invasive phenotype in hmt-3522 cells requires increased egf receptor signaling through both pi 3-kinase and erk 1,2 pathways. | we studied the invasion of hmt-3522 breast epithelial cells in response to epidermal growth factor (egf), and the associated signaling pathways. hmt-3522 t4-2 cells were shown to invade matrigel-coated transwell membranes in response to egf while hmt-3522 s-1 cells failed to invade when treated with egf. studies utilizing specific molecular inhibitors showed the importance of beta1 integrin, phosphatidylinositol 3 kinase (pi 3-kinase), p38, extracellular regulated kinase 1, 2 (erk 1,2) map kinas ... | 2002 | 12487410 |
| a helix initiation signal in t4 lysozyme identified by polyalanine mutagenesis. | to better understand the relation between sequence and structure, and in an attempt to simplify the protein folding problem, a series of alanine substitutions was introduced into bacteriophage t4 lysozyme. in contrast to previous studies in this system, which were restricted to single alpha-helices, the present analysis included a helix-turn-helix region, a loop-helix region, and two alpha-helices that were well separated in the three-dimensional structure. it was shown previously that t4 lysozy ... | 2002 | 12487988 |
| wall effects on dna stretch and relaxation. | hydrodynamic wall effects are treated with an image or reflection method. this method uses a mirror image of the molecule, with the opposite velocity, to satisfy the non-slip boundary condition of zero velocity of the liquid at the wall. molecules moving inside a slit require an infinite series of images, or reflections from both walls, whose effects converge slower for thinner slits. it is shown that, with the same external field, wall effects increase the electrophoretic stretch of dna, more s ... | 2002 | 12488019 |
| use of t4 lysozyme charge mutants to examine electrophoretic models. | the electrophoretic mobility of a macro-ion is affected in a complex manner by a variety of forces that arise from the applied field. coupling of the macro-ion and small-ion flows gives rise to non-conserved forces that are greater than those expected from ordinary hydrodynamic considerations. it is difficult to separate the steady-state hydrodynamic and electrodynamic contributions to the macro-ion mobility. membrane-confined electrophoresis (mce), a free solution technique, provides an experim ... | 2002 | 12488029 |
| statistical analysis of hormonal influences on arousal measures in ovariectomized female mice. | in a previous article (j. frohlich, m. morgan, s. ogawa, l. burton, and d. pfaff, 2001, horm. behav. 39, 39-47) an experiment to explore the structure of behavioral arousal in female mice was described. the present study extends this, to investigate the roles of thyroid hormone and estradiol in altering the statistical structure of arousal measures. each of four groups of ovariectomized female mice was administered either thyroxine (t4), estradiol benzoate (eb), both (t4 + eb), or neither (contr ... | 2002 | 12488108 |
| tc-99m-tetrofosmin thyroid scan in patients with low i-131 thyroid uptake. | low 24-hour thyroid uptake of i-131 (i-131 uptake) is a common finding that influences evaluation of the thyroid gland. | 2002 | 12489572 |
| necrosis of nasal and airway epithelium in rats inhaling vapors of artificial butter flavoring. | as the result of a high prevalence of fixed airways obstruction in workers at a microwave popcorn manufacturing plant, we examined the hypothesis that vapors of butter flavoring used in the manufacture of microwave popcorn and other foods can produce airway injury in rats. rats were exposed to vapors liberated from heated butter flavoring. rats were exposed for 6 h by inhalation and were necropsied 1 day after exposure. the exposure was found by gc-ms analysis to be a complex mixture of various ... | 2002 | 12490137 |
| ret proto-oncogene mutations affecting codon 790/791: a mild form of multiple endocrine neoplasia type 2a syndrome? | in patients with multiple endocrine neoplasia type 2a syndrome, prophylactic thyroidectomy is generally recommended at the age of 5 to 6 years. whether this recommendation is justified for exon 13 mutations is unknown. | 2002 | 12490841 |
| prolactin and thyroid hormones in patients with systemic sclerosis: correlations with disease manifestations and activity. | to determine serum levels of prolactin (prl) and thyroid hormones and to investigate the correlation between these hormones and different disease manifestations in patients with systemic sclerosis (ssc). | 2002 | 12491136 |
| [lymph node metastases in paranasal sinus carcinoma: prognostic value and treatment]. | the purpose of this report is to assess, on the basis of a sizeable study, the prognostic value of lymph node metastases in paranasal sinus carcinoma and, in particular, in squamous cell carcinoma of the maxillary sinus. we have reviewed the charts of 601 cases of paranasal sinus carcinoma between 1970 and 1999. all of the patients were treated surgically, alone or associated with chemotherapy and/or radiotherapy. the maxillary sinus tumors numbered 379 (153 squamous cell carcinomas, 15 undiffer ... | 2002 | 12510338 |
| estimation of energy balance at the individual and herd level using blood and milk traits in high-yielding dairy cows. | this study aimed to estimate individual and herd-level energy balance (eb) using blood and milk traits in 90 multiparous high-yielding holstein cows, held on a research farm, from wk 1 to 10 postpartum (p.p.) and to investigate the precision of prediction with successively decreased data sets simulating smaller herd sizes and with pooled samples. dry matter intake, milk yield, and bw were measured daily from parturition through wk 10 p.p. milk composition was determined 4 times per week, and mil ... | 2002 | 12512605 |
| depression and anxiety in hyperthyroidism. | our objective was to determine symptomatology of depression and anxiety in patients with untreated hyperthyroidism and compare with euthyroid patients. | 2002 | 12505101 |
| [action of spirulina platensis on bacterial viruses]. | the impact of the biomass of the blue-green microalga (cyanobacterium) s. platensis on bacteriophage t4 (bacterial virus) has been evaluated. the study revealed that the addition of s. platensis biomass into the agar nutrient medium, followed by sterilization with 2% chloroform and thermal treatment, produced an inhibiting or stimulating effect on the reproduction of the bacteriophage in escherichia coli b cells, depending on the concentration of s. platensis and the multiplicity of phage infect ... | 2002 | 12506621 |
| [a case of hypothyroidism due to hashimoto disease that presented elevations of free t3 and free t4 by thyroid hormone autoantibodies]. | when we commonly evaluate the thyroid function, we measure tsh, free t3 and free t4. however, there are some cases that are difficult to diagnose because of the existence of thyroid hormone autoantibodies. we experienced a case of a 14-year-old girl with diffuse struma whose tsh, free t3 and free t4 were elevated by detected with amerlex m free t3 and free t4 kits, although she did not have any symptoms. as the free t4 level was low by the equilibrium dialysis method, we diagnosed this case as h ... | 2002 | 12506859 |
| analysis of the baseplate region of phage ar1 that specifically infects escherichia coli o157:h7. | phage ar1 that specifically infects escherichia coli o157:h7 has been characterized previously for its primary host contact molecule, the long tail fiber. to strengthen its attachment to the host bacteria, the phage may use its baseplate for a second contact. this study investigated the characteristics of ar1 baseplate by deducing the responsible genes including wac and genes 9 to 15. the wedge pin g11 and the short tail fiber g12 varied the most, whereas the others were highly conserved compare ... | 2002 | 12542256 |
| [expression of cyclooxygenase-2 in human transitional cell bladder carcinomas]. | cyclooxygenase(cox) is a rate-limiting enzyme in prostaglandin synthesis. recent study suggested that cox-2 was associated with carcinogenesis. this study was designed to investigate the role of cox in the development and progression of bladder cancer through examining the expression of cox-1 and cox-2 in human bladder cancer tissue, normal bladder mucosa, and cystitis tissue. | 2002 | 12526218 |
| the significance of tenascin-c serum level as tumor marker in squamous cell carcinoma of the head and neck. | tenascin, an extracellular matrix glycoprotein, is transiently present in embryonic tissue, in benign granulation tissue, but also in several highly anaplastic tumors like fibrosarcoma, melanoma and squamous cell carcinoma of the skin. this study was performed to validate elevated tenascin serum levels as a possible marker for head and neck squamous cell carcinomas (hnscc). | 2002 | 12530049 |
| effects of kojic acid on thyroidal functions in rats by single-dose administration and in cultured rat thyroid cells (frtl-5 cells). | the effects of kojic acid (ka) on thyroidal function were studied by single-dose administration in rats and in cultured rat thyroid cells (frtl-5 cells). in rats receiving a single dose of 1,000 mg/kg ka orally, the 125i uptake from blood into the thyroid gland was significantly lower than that of the control group from 30 min to 24 hr after administration. the 125i organification activity of the ka groups was significantly lower than control from 30 min to 6 hr after administration. however, th ... | 2002 | 12533912 |
| basal tsh levels compared with trh-stimulated tsh levels to diagnose different degrees of tsh suppression: diagnostic and therapeutic impact of assay performance. | the estimated prevalence of endogenous subclinical hyperthyroidism varies from 4% to 6% and a basal thyroid stimulating hormone (tsh) level < 0.5 mu l-1 may be associated with increased mortality in subjects over 60 years of age who are not on thyroid medication. exogenous tsh suppression is a mainstay in the treatment of thyroid cancer. because of recent concerns about potential adverse effects, especially of endogenous tsh suppression on bone, the cardiovascular system and cognitive functions, ... | 2002 | 12534453 |
| [chemotherapy of locally advanced t4 and metastatic n+, m+ bladder tumors]. | 2002 | 12536921 | |
| experimental model for ophthalmopathy in balb/c and outbred (cd-1) mice genetically immunized with g2s and the thyrotropin receptor. | in an attempt to develop an animal model for thyroid-associated ophthalmopathy (tao) we have genetically immunized balb/c and outbred (cd-1) mice with cdnas encoding the thyroid and eye muscle shared protein g2s and full length human thyrotropin receptor (tshr). firstly, balb/c mice were immunized with cdnas for g2s and the tshr, alone or in tandem with cdnas for interleukin (il)4 or il12. control mice were immunized with empty vehicle only. sera from the great majority of experimental mice cont ... | 2002 | 12568121 |
| [decontamination of dental unit waterlines using disinfectants and filters]. | bacterial contamination of the dental unit water system can become a health problem for patients, particularly if they are immunodepressed. the present study has had the purpose of evaluating the effectiveness of methods of chemical decontamination using different disinfectants (peracetic acid, hydrogen peroxide, silver salts, chloramine t, glutaraldehyde t4) and methods of physical decontamination using synthetic membranes for the filtration of water. a preliminary removal procedure of the biof ... | 2002 | 12548184 |
| effects of combined androgen blockade on bone metabolism and density in men with locally advanced prostate cancer. | to investigate whether combined androgen blockade (cab) produces any adverse effects on bone metabolism and mineral density in patients with locally advanced prostate cancer. | 2002 | 12549644 |
| phase ii study of neoadjuvant chemotherapy in patients with surgically-proven, unresectable stage iii non-small cell lung cancer. | the aim of this study was to assess whether patients with truly unresectable (bulky extracapsular n2, t4 for tracheobronchial angle or mediastinal organ invasion) stage iii non-small cell lung cancer (nsclc), as proven by cervical mediastinoscopy supplemented or not by left anterior mediastinoscopy and fiberoptic bronchoscopy or thoracotomy, could become resectable after induction cisplatin-containing chemotherapy. in addition, we studied the value of preoperatory magnetic resonance imaging (mri ... | 2002 | 12552949 |
| the evolution of transthyretin synthesis in the choroid plexus. | choroid plexus has the highest concentration of transthyretin (ttr) mrna in the body, 4.4 microg ttr mrna/g wet weight tissue, compared with 0.39 microg in the liver. the proportion of ttr to total protein synthesis in choroid plexus is 12%. all newly synthesized ttr is secreted towards the ventricles. net transfer of t4 occurs only towards the ventricle and depends on ongoing protein synthesis. thyroxine-binding globulin (tbg), ttr and albumin form a "buffering" system for plasma [t4] because o ... | 2002 | 12553420 |
| mechanisms of molecular recognition: crystal structure analysis of human and rat transthyretin inhibitor complexes. | structure-activity data show that many pharmacological agents are strong competitive inhibitors for thyroxine (t4) binding to transthyretin (ttr) and that this competition can interfere with their normal pharmacological actions. ttr is a tetrameric serum protein responsible for the transport of 20% of the circulating t4 in man, while in lower vertebrates such as rats it is the only carrier. the sequence of rat ttr is 85% homologous to the human protein. crystallographic analyses of ligand co-cry ... | 2002 | 12553424 |
| transthyretin in fish: state of the art. | relatively little is known about thyroid hormone-binding proteins in fish and, until recently, the thyroid hormones (ths), thyroxine (t4) and triiodothyronine (t3), had only been found in fish plasma bound to albumin and lipoproteins. recently, transthyretin (ttr) was cloned in a teleost fish, the sea bream (sb); it is composed of 130 amino acids and shares 47-54% sequence similarity with other vertebrate ttr and binds preferentially t3. homology modelling of sbttr based upon the crystallographi ... | 2002 | 12553425 |
| transthyretin as a thyroid hormone carrier: function revisited. | thyroid hormones are essential for normal mammalian development and for normal metabolism. thyroxine (t4) is the principal product synthesized by the thyroid follicles, and triiodothyronine (t3), the biologically active hormone, derives mainly from tissue t4 deiodination. more than 99% of the circulating hormone is bound to plasma proteins, mainly to thyroxine-binding globulin, transthyretin and albumin in man, and to transthyretin and albumin in rodents. the role of plasma proteins in the trans ... | 2002 | 12553433 |
| heterogeneity of the thyroglobulin epitopes associated with circulating thyroid hormone autoantibodies in hashimoto's thyroiditis and non-autoimmune thyroid diseases. | we previously implicated tg leakage from fine-needle aspiration biopsy (fnab) as responsible for circulating thyroid hormone autoantibodies (thab). however, thab were not always associated with tgab. in the literature these negative findings have been interpreted against a role of tg as the antigen for thab. to evaluate the tgab status more fully and to gain information on tg epitopes involved in thab development, we measured: 1) tgab with an independent hemagglutination assay (ha), and 2) epito ... | 2002 | 12553558 |
| [effect of microwave coagulation and surgery to treat the cancer of the floor of mouth]. | the aim of this article was to clarify the value of microwave coagulation to treat the cancer of the floor of mouth by comparing the effect of microwave and surgery. | 2002 | 12768714 |
| [role of iodine-131 in the management of differentiated thyroid cancers (vesicular origin)]. | radioodine-131 has an important place in the management of well-differentiated thyroid cancer. patient preparation for radioiodine-131 administration must be rigorous and is based on the stimulation of endogenous tsh production, which requires a hypothyroid state after withdrawal of suppressive t4-therapy. the introduction of recombinant human tsh would simplify the protocol of preparation and improve the quality of life of patients. the diagnosis place of radioiodine-131 knew significant change ... | 2002 | 12703121 |
| [preservative surgery of t4 glottic cancer]. | to explore new methods of preservative surgery for t4 glottic cancer and to evaluate their long term results. | 2002 | 12772420 |
| severe dysplastic lesions in the colon - how aggressive should we be? | introduction: biopsies of colonic lesions are often reported as showing dysplasia, though in reality some lesions may harbour invasive malignancy. aim: to assess the risk of underlying invasive malignancy in sessile polyps where biopsies had shown severe dysplasia and also to attempt to define a management strategy in such patients. methods: between 1997 and 2001, 30 patients were diagnosed as having severe dysplasia using morson's criteria in colonic lesions not amenable for endoscopic polypect ... | 2002 | 12780579 |
| factors affecting survival after palliative resection of colorectal carcinoma. | objective: to determine the factors affecting survival following palliative large bowel resection for colorectal adenocarcinoma. patients and method: from the colorectal cancer database of a single institution patients who had a palliative resection of a colorectal cancer from 1980 to 1993 inclusive were identified. survival curves were constructed using the kaplan-meier method. criteria studied were sex, age at operation, site of tumour, t, n and m status, tumour differentiation, involvement of ... | 2002 | 12780652 |