Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| validation of a new serologic test for the detection of helicobacter pylori. | in order to determine normal ranges for positive and negative titres using a new commercially available second generation serologic elisa test for the detection of helicobacter pylori igg antibodies (malakit by biolab, limal, belgium) we investigated 560 asymptomatic pregnant women aged 20 to 44. 128 patients (22.9%) had a positive titre for helicobacter pylori. although we were able to observe an increase of the number of seropositive subjects with advancing age, a significant increase in titre ... | 1993 | 8140846 |
| [helicobacter pylori: pathogenic role]. | 1993 | 8145493 | |
| comparison of urease gene primer sequences for pcr-based amplification assays in identifying the gastric pathogen helicobacter pylori. | different genomic dna samples and primer sequences were evaluated in urease (ure) gene-based pcr assays for rapid identification of helicobacter pylori. purified dna and heated (boiled) cell lysates of bacterial cultures from gastric biopsies were tested with three primer sets for unique internal urea, urea+b and urec sequences. the heated-lysates of h. pylori were quick to prepare but more frequently gave unexpected variable or negative pcr results than assays performed on purified dna, which w ... | 1993 | 8145775 |
| [combined therapy of duodenal ulcer associated with helicobacter pylori with electromagnetic decimeter waves and colloidal bismuth subcitrate]. | 1993 | 8154113 | |
| [therapeutic reflections and strategies on the topic of helicobacter pylori: what, who, why?]. | 1993 | 8161613 | |
| short report: smoking habits and the acquisition of metronidazole resistance in patients with helicobacter pylori-related gastritis. | thirty-three dyspeptic patients with colonization of helicobacter pylori in the gastric antrum were treated with tripotassium dicitrate bismuthate 120 mg q.d.s. for 28 days and metronidazole 250 mg q.d.s. for 10 days starting on day 19. five weeks after cessation of this treatment regimen h. pylori was eradicated in 23 patients. in 8 of the remaining 10 patients, h. pylori had become resistant to metronidazole. in this study resistance was significantly associated with smoking habits, but not wi ... | 1993 | 8161676 |
| helicobacter pylori: microbiology of a 'slow' bacterial infection. | the bacterium helicobacter pylori lives in the gastric mucus layer of humans and induces a chronic inflammatory response that can result in both peptic ulceration and gastric neoplasms. helicobacter pylori infection can be considered as a 'slow', adaptive and autoregulating process. the mechanisms by which this slow bacterial pathogen survives and interacts with the host immune system may provide a model for other persistent mucosal pathogens. | 1993 | 8162405 |
| [clinical and pathological characteristics of helicobacter pylori-associated chronic gastritis]. | to define the clinical and pathological characteristics of helicobacter pylori-associated gastritis, 173 patients with chronic gastritis, including 99 hp-positive and 74 hp-negative patients were studied. we found that there were no significant differences between hp-positive and hp-negative patients with regard to clinical symptoms, gastric acid secretion and serum basal gastrin level, whereas the grades of chronic gastritis and active gastritis were markedly higher in hp-positive patients. 91. ... | 1993 | 8156840 |
| histology compared with chemical testing for urease for rapid detection of helicobacter pylori in gastric biopsy specimens. | gastric biopsy specimens from 283 patients with ulcer and non-ulcer dyspepsia attending five gastroenterology clinics in the northern region of the united arab emirates (uae) were tested by the agar gel test (n = 115) or the ultra-rapid endoscopy room test (n = 168) for the presence of helicobacter pylori urease. results were compared with a histological technique using the romanowsky type (diff-3) stain for detecting h pylori in both antral and body type gastric mucosa. a sensitivity of 94% and ... | 1993 | 8157765 |
| a systematic overview (meta-analysis) of outcome measures in helicobacter pylori gastritis trials and functional dyspepsia. | to critically appraise the use of outcome measures in treatment trials of helicobacter pylori positive non-ulcer dyspepsia patients. | 1993 | 8171300 |
| [the rapid microscopic diagnosis of helicobacter pylori as the etiological agent of gastric and duodenal ulcers]. | 1993 | 8173217 | |
| [helicobacter pylori (h.p.) in the etiology of peptic (gastric and duodenal) ulcer]. | 1993 | 8173219 | |
| identification and characterization of a helicobacter pylori hemolysin. | 1993 | 8173790 | |
| effect of age, helicobacter pylori infection, and gastritis with atrophy on serum gastrin and gastric acid secretion in healthy men. | gastric acid secretion has been considered to decline with increasing age but this view is being re-evaluated as the importance of helicobacter pylori infection emerges. this study aimed to determine the effect of age, h pylori, and gastritis with atrophy on the serum gastrin concentration, gastric secretory volumes, and acid output in healthy, asymptomatic men. young men (mean (sd) age 22.9 (0.6) years; n = 22) were compared with old men (72.9 (1.2) years; n = 28) in respect of basal serum gast ... | 1993 | 8174948 |
| effect of eradication of helicobacter pylori on gastric juice ascorbic acid concentrations. | ascorbic acid, the reduced form of vitamin c, may protect against gastric cancer and is secreted by the normal stomach. secretion is impaired in helicobacter pylori (h pylori) associated chronic gastritis. this study examined if eradication of h pylori improves gastric juice ascorbate values. fasting gastric juice and plasma samples were collected at endoscopy from patients participating in trials of h pylori eradication for duodenal ulcer disease and intestinal metaplasia before and up to 15 mo ... | 1993 | 8174949 |
| eradicating helicobacter pylori infection lowers gastrin mediated acid secretion by two thirds in patients with duodenal ulcer. | helicobacter pylori (h pylori) raises serum gastrin but it is unclear whether this stimulates increased acid secretion. gastrin mediated acid secretion and plasma gastrin after the intravenous infusion of gastrin releasing peptide was studied in nine h pylori negative and nine h pylori positive healthy volunteers, and in 11 duodenal ulcer patients. nine of the last group were re-examined one month after eradication of h pylori. the median acid output (mmol/h) to gastrin releasing peptide (40 pmo ... | 1993 | 8174954 |
| [the principles of administering drug and non-drug treatment methods in peptic ulcer]. | as the result of the study optimal schemes of the ulcer disease treatment were elaborated. they include microwave resonance therapy, immunomodulatory and antibacterial drugs with regard to localisation, depth and size of the ulcerous lesion, exacerbation rate, degree of secondary immune disorders and seeding of gastric mucosa with helicobacter pylori. the treatment suggested allows to shorten the terms of ulcer cicatrization, reduces exacerbation rate and ensures clinico-endoscopic remission in ... | 1993 | 8209501 |
| [the relationship of duodenal peptic ulcer and gastroduodenitis to a chronic staphylococcal infection]. | tonsillar and pharyngeal smears revealed growth of pathogenic microorganisms, mainly of staphylococcus aureus, in 58.0 +/- 3.7% of 174 patients with duodenal ulcer and gastroduodenitis during remission or unstable remission, in 40.0 +/- 5.3% of 85 patients with other gastroenterological diseases and in 17.5 +/- 6.0% of 40 subjects constituting control group. urease activity ratio (biological marker of helicobacter pylori) was found to be approximately the same in every group of patients vs 11.1 ... | 1993 | 8209503 |
| the fate of ingested 14c-urea in the urea breath test for helicobacter pylori infection. | the metabolic fate of the radioactive carbon in the 14c-urea breath test for helicobacter pylori was investigated in 18 subjects. after ingestion of labelled urea, breath was sampled for 24 h, and urine was collected for 3 days. subjects were designated high or low expirers on the basis of their breath counts, and this agreed well with h. pylori serologic analyses. when given 185 or 37 kbq of 14c-urea, 51% (sd = 16%, n = 11) of the label was recovered from the breath of high expirers, and 7% (sd ... | 1993 | 8210978 |
| helicobacter pylori infection and exaggerated gastrin release. effects of inflammation and progastrin processing. | helicobacter pylori infection is associated with exaggerated gastrin release. we investigated whether this abnormality was due to the bacteria or the immune response. fasting and meal-stimulated 'total' and amidated gastrin were measured in 10 h. pylori-infected volunteers before eradication therapy, after 2 and 14 days of therapy, and 4 weeks after completion of therapy. the exaggerated meal-stimulated gastrin concentration remained unchanged after 2 days of therapy, although the polymorphonucl ... | 1993 | 8210984 |
| is helicobacter pylori involved in the pathogenesis of the gastritis characteristic of pernicious anaemia? comparison between pernicious anaemia relatives and duodenal ulcer relatives. | the aim of the study was to evaluate whether helicobacter pylori could be involved in the early stages of the severe corpus atrophy that is characteristic of overt pernicious anaemia and is usually h. pylori-negative. the behaviour of h. pylori infection and chronic gastritis was studied in 159 first-degree relatives of pernicious anaemia (pa) probands and was compared with that in 137 first-degree relatives of duodenal ulcer (du) probands. du is as a rule associated with h. pylori infection. pa ... | 1993 | 8210987 |
| [chronic recurrent abdominal pain in school children]. | the diagnostic approach of children with recurrent abdominal pain (rap) was investigated by means of a standard protocol. the protocol consisted of recently developed laboratory techniques and 'routine' investigations. in addition, all patients were subjected to an extensive psychological investigation. the main results show that in a high percentage (42%) of patients organic abnormalities could be found. particularly the small bowel seemed to be involved in the pathogenesis of the complaints. f ... | 1993 | 8211938 |
| [gastritis, ulcerous syndrome without ulcer and helicobacter pylori (250 cases)]. | 1993 | 8212332 | |
| [is there to be a renaissance of surgical treatment of ulcers?]. | medical treatment of peptic ulcer disease with h2-blockers has over the last ten years practically replaced surgical treatment of this condition, due to greater patient compliance, high effectivity and negligible side-effects. the treatment is, however, strained by the relatively high cost of medication. development of techniques for laparoscopic vagotomy, which is associated with a considerably reduced postoperative morbidity and reconvalescence as well as entailing only one to two days hospita ... | 1993 | 8212365 |
| [helicobacter pylori in patients with diabetes mellitus]. | the authors assessed the frequency of helicobacter pylori in diabetic patients with gastroduodenal ulceration and non-ulcerative dyspepsia. they evaluated a group of 91 hospitalized type ii diabetics which non-ulcerative dyspepsia, endoscopically confirmed ulceration of the duodenal bulbus and gastric ulceration. the control group was formed by 98 hospitalized non-diabetic subjects. between the two groups there was no difference in the frequency of helicobacter pylori in non-ulcerative dyspepsia ... | 1993 | 8212614 |
| [atrophy of the gastric mucosa and helicobacter pylori]. | the authors investigated the prevalence of helicobacter pylori (h. p.) in atrophic gastritis in the antrum and/or in the corpus of the stomach (groups i-iv), as compared with mucosae without atrophy. criteria for elimination were age under 50 years, a case-history of the use of antibiotics during the last 6 months and chronic ingestion of alcoholic beverages. group iv was formed by probands with pernicious anaemia who were divided into sub-group iva with atrophy of the corpus and sub-group ivb w ... | 1993 | 8212615 |
| role of serology in monitoring treatment for helicobacter pylori infection in elderly patients. | fifteen elderly patients with type b gastritis caused by helicobacter pylori infection were treated with triple therapy consisting of colloidal bismuth subcitrate, amoxycillin and metronidazole. all were followed up every 6 weeks for 3 months. after triple therapy, eradication of the infection was confirmed in 12 patients (85%) by histology and bacteriology. in this group, a significant reduction in igg antibody levels against h. pylori was detected (p < 0.001). in a control group of 15 patients ... | 1993 | 8213329 |
| a role for culture in diagnosis of helicobacter pylori-related gastric disease. | in this study, our objective was to determine the presence of helicobacter pylori and other rapid urease-positive (rup) organisms in gastric biopsies in 70 patients, 30 of whom had ulcers or erosions. a retrospective chart review was undertaken to correlate diagnostic tests (culture and direct urease) with results of endoscopic examination and the patient's clinical information. eleven of 70 (15.7%) patients' biopsies were positive by both culture and direct urease for h. pylori, seven (10%) pat ... | 1993 | 8213715 |
| identification and characterization of an atpase system of helicobacter pylori and the effect of proton pump inhibitors. | 1993 | 8213737 | |
| detection of antibodies to helicobacter pylori using oral fluid specimens. | 1993 | 8215083 | |
| nizatidine prevents peptic ulceration in high-risk patients taking nonsteroidal anti-inflammatory drugs. | nonsteroidal anti-inflammatory drug (nsaid) use is increasingly recognized as a major factor associated with peptic ulcer disease and complications. we undertook a multicenter, double-blind, placebo-controlled trial to evaluate efficacy and safety of nizatidine in preventing ulcer formation in patients with osteoarthritis who were taking nsaids. | 1993 | 8215749 |
| effects of indomethacin on intragastric ph and meal-stimulated serum gastrin secretion in rheumatoid arthritis patients. | the effects of oral indomethacin on intragastric ph and serum gastrin were investigated in rheumatoid arthritis patients. nine patients (1 male, 8 female) without a history of peptic ulcer disease and 6 patients with a history of peptic ulcer disease (5 male, 1 female) were studied. to obviate helicobacter pylori infection as a confounding factor, only patients with positive h. pylori serology were included. after a 5-day period of placebo treatment and after a 5-day period of indomethacin (50 m ... | 1993 | 8218753 |
| omeprazole versus famotidine in the healing and relapse of duodenal ulcer. | sixty patients with symptomatic duodenal ulcer were randomized to receive either omeprazole (20 mg each morning) or famotidine (40 mg at night time) for 2-4 weeks in a double-blind parallel group clinical trial. healing rates were higher with omeprazole in comparison with famotidine after 2 weeks (77% vs. 40%, p < 0.001) and 4 weeks (93% vs. 80%, p = 0.2) of treatment. assessment of daily diary cards completed by all patients revealed that omeprazole rapidly relieved ulcer-related day pain and n ... | 1993 | 8218758 |
| short report: treatment of helicobacter pylori-associated duodenal ulcer with omeprazole plus antibiotics. | omeprazole heals most duodenal ulcers after 4 weeks of treatment but relapse is common. eradication of helicobacter pylori is associated with reduced rate of ulcer relapse. this study investigates the effect of omeprazole with antibiotics in h. pylori-associated duodenal ulceration. forty-three patients with endoscopically proven duodenal ulcer and h. pylori entered this study. treatment consisted of 20 mg omeprazole daily (four weeks) and seven days (first week) treatment with 400 mg metronidaz ... | 1993 | 8218761 |
| immunocytochemical quantitation of inflammatory cells associated with helicobacter pylori infection. | inflammatory cells in helicobacter pylori-associated gastritis (hag) were quantified. the results were compared with the gastric biopsy samples from patients with non-helicobacter pylori gastritis (non-hag). in order to detect immunocytochemically sensitive antigens, the biopsy samples were acetone-fixed at -20 degrees c and processed into glycol methacrylate at 4 degrees c. parallel routine biopsy samples were formalin-fixed and paraffin-embedded. a larger, more selective retrospective study wa ... | 1993 | 8219923 |
| helicobacter pylori, pepsinogen, and risk for gastric adenocarcinoma. | the objective of this project was to determine the association of helicobacter pylori infection and serum pepsinogen levels on subsequent risk for gastric adenocarcinoma. this nested case-control study was set in a large health maintenance organization. one hundred thirty-six cases of gastric adenocarcinoma and 136 matched controls without adenocarcinoma from a large cohort that had contributed serum in the 1960's were studied. the presence of igg against h. pylori had previously been determined ... | 1993 | 8220091 |
| six-month maintenance treatment of duodenal ulcer with sucralfate: influence on antral gastritis and helicobacter pylori antral colonization--a prospective uncontrolled study. | fifty-four patients (41 men, 13 women), aged 17 to 78 years (mean +/- sd, 48.13 +/- 13.5 years), with endoscopically confirmed healing of their duodenal ulcer after treatment with sucralfate (2 gm bid for 4 to 8 weeks) were recruited for this study. they were started on a 6-month maintenance treatment with sucralfate 1 gm bid. endoscopy was done at the end of the 6-month period or whenever there was any evidence of ulcer relapse. helicobacter pylori antral colonization (clo test) and antral gast ... | 1993 | 8221815 |
| [the nomenclature of helicobacter pylori]. | 1993 | 8222974 | |
| [diagnosis of helicobacter pylori infection by 13c-urea breath test]. | depending on the character for the helicobacter pylori (hp) to decompose the urea by its endogenous urease, we have investigated the possibility to diagnose hp infection by 13c-urea breath test in 55 cases. also, we compared the diagnostic results from 13c-urea breath test with those from culture, histology, and rapid urease test. the satisfied accuracy for the detection of hp infection with 13c-urea breath test was indicated. | 1993 | 8222981 |
| phospholipase activity of helicobacter pylori and its inhibition by bismuth salts. biochemical and biophysical studies. | in this study we measured phospholipase a (pla) and c (plc) activity of media filtrates and french press lysates of the gastritis-inducing bacteria helicobacter pylori. we report here that both h. pylori lysates and filtrates contain pla1, pla2, and c enzymes, which readily hydrolyze a radiolabeled dipalmitoylphosphatidylcholine (dppc) and phosphorylcholine substrates, respectively. the specific activity of both pla and c enzymes were greatest in the 6.5-7.0 and 8.4-8.8 ph ranges, respectively. ... | 1993 | 8223083 |
| serum pepsinogens as markers of response to therapy for helicobacter pylori gastritis. | we have investigated the effect of therapy for helicobacter pylori gastritis on serum concentrations of pepsinogen i and ii in 43 patients. in the 22 patients in whom therapy resulted in dramatic decrease in gastritis scores and in clearance of the bacteria, there was a highly significant (p = 0.0001) fall in mean serum pepsinogen ii from 13.3 +/- 0.8 to 7.9 +/- 0.7 micrograms/liter, and a less pronounced fall in pepsinogen i from 89.0 +/- 5.9 to 78.5 +/- 0.4 micrograms/liter (p = 0.01). these c ... | 1993 | 8223084 |
| gastrospirillum hominis in asymptomatic, healthy individuals. | gastrospirillum hominis is a spiral-shaped bacterium found in the stomach. it has been implicated as a possible cause of chronic gastritis. we report two cases of g. hominis colonization observed in a series of 175 healthy, asymptomatic volunteers investigated for helicobacter pylori. none of the volunteers had symptoms or a history of gastrointestinal disease. both carriers of g. hominis had histological signs of chronic, active antral gastritis. multiple tests for h. pylori were negative. the ... | 1993 | 8223085 |
| humoral immune response against helicobacter pylori as determined by immunoblot. | an immunoblot method has been evaluated to diagnose helicobacter pylori infection serologically by comparing 69 serum specimens from patients with a positive gram stain and/or culture result and a positive urease test on biopsy material, as well as 51 serum specimens from patients with at least 4 negative urease tests, and negative microscopy and culture results. sensitivity and specificity was found to be 100%. recognition of the cross-reacting flagellin (66 kda), flagellar sheath protein (51 k ... | 1993 | 8223405 |
| helicobacter pylori positivity. | 1993 | 8223793 | |
| na+,k(+)-atpase of gastric cells. a target of helicobacter pylori cytotoxic activity. | the present study shows a direct impairing action of a cytotoxin-producing helicobacter pylori strain on the na+,k(+)-atpase (evaluated as k(+)-dependent phosphatase activity) of human gastric epithelial cells in culture. the toxin itself is likely involved in this action which may also account for the cell edema found in vivo in helicobacter pylori-colonized stomach. | 1993 | 8224240 |
| helicobacter pylori-associated gastric ulcer mimicking a gastric malignancy. | 1993 | 8224716 | |
| correlation between vacuolating cytotoxin production by helicobacter pylori isolates in vitro and in vivo. | approximately 50 to 60% of helicobacter pylori isolates produce a vacuolating cytotoxin in vitro. to assess cytotoxin production in vivo, we sought to determine whether infection with a tox+ h. pylori strain is associated with the presence of serum antitoxin antibodies. h. pylori isolates and serum samples were obtained from 30 patients, and serum samples were obtained from 20 uninfected patients as controls. sera were tested by enzyme-linked immunosorbent assay for reactivity with the purified ... | 1993 | 8225576 |
| purification of helicobacter pylori superoxide dismutase and cloning and sequencing of the gene. | the superoxide dismutase (sod) of helicobacter pylori, a pathogenic bacterium which colonizes the gastric mucosa, evoking a marked inflammatory response, was purified and characterized, and the n-terminal amino acid sequence was determined. the enzyme consists of two identical subunits each with an apparent molecular weight of 24,000. analysis of the primary structure and inhibition studies revealed that h. pylori possesses a typical procaryotic iron-containing enzyme. no other isoenzymes could ... | 1993 | 8225605 |
| comparison of three methods for the determination of the sensitivity of helicobacter pylori to metronidazole. | a comparison of various methods for the determination of the sensitivity of helicobacter pylori to metronidazole was undertaken. the validity of the agar dilution, the disc diffusion and the epsilometer (e) test was studied using a total of 86 strains, 16 of which were known to be resistant to metronidazole. all tests were carried out on mueller-hinton agar with 5% sheep blood. the results of the disc diffusion and the e-test were highly significantly (p < 0.001) associated with those of the aga ... | 1993 | 8226415 |
| serum pepsinogen i and ii concentrations and igg antibody to helicobacter pylori in dyspeptic patients. | to investigate the association between histologically confirmed gastritis, carriage of helicobacter pylori and pepsinogen (pg) i and pg ii concentrations. | 1993 | 8227432 |
| prevalence of lymphoid follicles and aggregates in helicobacter pylori gastritis in antral and body mucosa. | to evaluate the prevalence of lymphoid follicles and aggregates in the antral and body mucosa in helicobacter pylori gastritis and to assess if there were correlations with ulcers in the duodenum, pylorus, or stomach, and with chronic antral erosions. | 1993 | 8227434 |
| prostaglandin e2 in gastric mucosa of children with helicobacter pylori gastritis: relation to thickness of mucus gel layer. | to evaluate the changes in mucus gel layer thickness and prostaglandin e2 (pge2) content caused by helicobacter pylori infection in the antral mucosa of children: to assess whether decreased mucus gel thickness is related to pge2 production. | 1993 | 8227435 |
| is gastric metaplasia essential for duodenal ulcer? | multiple biopsies were taken from the duodenum of 100 patients (46 active duodenal ulcer, 14 healed duodenal ulcer, 40 control subjects) to detect duodenitis, gastric metaplasia and helicobacter pylori (hp). histamine-induced congo-red staining of the duodenal bulb was performed in additional 25 cases of active duodenal ulcer to determine the presence of functioning parietal cells in the duodenum. the incidence of duodenitis was 45% in control subjects and 76.7% in patients with duodenal ulcer ( ... | 1993 | 8228080 |
| helicobacter pylori gastric infection and sideropenic refractory anemia. | 1993 | 8229554 | |
| effect of helicobacter pylori colonisation on gastric mucosal eicosanoid synthesis in patients taking non-steroidal anti-inflammatory drugs. | colonisation with helicobacter pylori may influence susceptibility to gastroduodenal injury and ulceration in patients taking non-steroidal anti-inflammatory drugs (nsaids). the aim of this study was to determine if helicobacter pylori colonisation altered eicosanoid synthesis by gastric mucosa in these patients. sixty five patients with long-standing nsaid intake and 23 control subjects underwent endoscopy. in vitro gastric antral biopsies were stimulated by vortex mixing and eicosanoid measure ... | 1993 | 8314505 |
| influence of helicobacter pylori, sex, and age on serum gastrin and pepsinogen concentrations in subjects without symptoms and patients with duodenal ulcers. | the relation between helicobacter pylori (h pylori) infection and fasting gastrin and pepsinogen-i and -ii concentrations was evaluated in 278 volunteers without symptoms and the results were compared with the values obtained in 35 patients with duodenal ulcers. h pylori infection was determined with the 13c-urea breath test in subjects without symptoms and with endoscopy, biopsy (histology and culture), and quick urease test (clo-test) in patients with duodenal ulcers. gastrin and pepsinogen-i ... | 1993 | 8314506 |
| helicobacter pylori related hypergastrinaemia is the result of a selective increase in gastrin 17. | helicobacter pylori infection increases the serum concentration of gastrin, and this may be one of the mechanisms by which it predisposes to duodenal ulceration. different forms of circulating gastrin were studied both basally and postprandially in 13 duodenal ulcer patients before and one month after eradication of h pylori. three antisera that are specific for particular regions of the gastrin molecules were used. gel chromatography indicated that > 90% of the circulating gastrin consisted of ... | 1993 | 8314507 |
| a study of the pathogenesis of helicobacter pylori negative chronic duodenal ulceration. | in the past five years 12 patients have been identified presenting with chronic duodenal ulcer (du) disease and with no evidence of current or recent helicobacter pylori (h pylori) infection. four of them were taking regular non-steroidal anti inflammatory agents, one was subsequently found to have crohn's disease of the duodenum, and one to have the zollinger-ellison syndrome. the remaining six patients with idiopathic du disease were remarkable for their absence of the a1 blood antigen gene. d ... | 1993 | 8314508 |
| diagnosis of helicobacter pylori infection by using pyloriset eia-g and eia-a for detection of serum immunoglobulin g (igg) and iga antibodies. | we evaluated the performance of new enzyme immunoassay (eia) kits (pyloriset; orion corporation, orion diagnostica, espoo, finland) for the detection of immunoglobulin g (igg) and iga antibodies to helicobacter pylori in serum. serum samples from 195 patients with upper abdominal complaints were collected. biopsy specimens of the gastric mucosae were taken for histological analysis and bacterial culture. the sensitivity, specificity, and positive and negative predictive values, and efficacy of t ... | 1993 | 8314985 |
| [helicobacter pylori infections]. | 1993 | 8315343 | |
| duodenal ulcer is a multifactorial disorder--the role of pepsinogen i. | serum pepsinogen i (pgi) levels were measured in 231 duodenal ulcer (du) patients and 100 sex- and age-comparable healthy controls. significantly higher mean serum pgi levels were found in du patients than in controls (124.7 +/- 3.4 ng/ml v. 92.9 +/- 2.3 ng/ml; p < 0.001) (mean +/- se). these levels were higher in male du patients than in female du patients (128.5 +/- 3.9 ng/ml v. 107.4 +/- 6.4 ng/ml; p < 0.05). smoking was associated with elevated serum pgi levels in du patients (145.3 +/- 5.1 ... | 1993 | 8316925 |
| hyperplastic polyposis and diffuse carcinoma of the stomach. a study of a family. | the authors previously described a large pedigree with familial gastric polyposis and a high incidence of gastric cancer and demonstrated the autosomal dominant pattern of inheritance. the current study described the histologic and immunohistologic features of the lesions in an attempt to clarify the mechanisms underlying gastric carcinogenesis in this family. | 1993 | 8319165 |
| treatment and long-term follow-up of helicobacter pylori-associated duodenal ulcer disease in children. | in a 7-year period, 33 children had endoscopically documented duodenal ulcer disease. of the 33 children, 29 had helicobacter pylori antral gastritis. all children with h. pylori-associated duodenal ulcer disease were treated with antibiotics but no h2-receptor blocking agents. for the first 3 years of the study, initial treatment was with bismuth subsalicylate or amoxicillin for 6 weeks. for the latter 4 years, therapy with both bismuth subsalicylate and amoxicillin for 6 weeks was used initial ... | 1993 | 8320625 |
| imprint cytology--a cheap, rapid and effective method for diagnosing helicobacter pylori. | to compare the efficacy of imprint cytology, histology and clo-test (for biopsy urease) in detecting helicobacter pylori infection, antral biopsies were taken from 239 patients undergoing upper gastrointestinal endoscopy. both imprint cytology and histology showed the presence of h. pylori in 215 (90%) patients. the sensitivity and specificity of imprint cytology vis-à-vis histology was noted to be 100%. the clo-test was performed in 165 patients and was positive in 130 (79%) patients. the sensi ... | 1993 | 8321793 |
| role of helicobacter pylori infection and duodenogastric reflux in the pathogenesis of alkaline reflux gastritis after gastric operations. | in patients undergoing gastric operations, we studied the relationship between data suggesting alkaline reflux gastritis (symptoms, endoscopic alterations and histologic lesions) and two factors that produce chronic gastritis (helicobacter pylori and duodenogastric reflux). of 225 patients who underwent operations for gastroduodenal gastric ulcer at our general surgery unit between 1980 and 1982, 63 agreed to undergo endoscopy and biopsies. of these 63 patients, 38 agreed to a test to quantify d ... | 1993 | 8322136 |
| giant fold gastritis--a special form of helicobacter pylori associated gastritis. | we investigated the question as to how frequently helicobacter pylori gastritis is present in cases of endoscopically detected giant folds of the corpus and fundic mucosa, and whether this gastritis differs from helicobacter pylori associated gastritis with no giant folds. biopsy material obtained from 138 patients with giant folds (sex ratio: 1.0 men: 105 women; average age 61.0 years) was evaluated histologically and compared with that obtained from 1,196 patients with h. pylori associated gas ... | 1993 | 8322475 |
| [helicobacter pylori associated gastritis and primary stomach lymphoma]. | 1993 | 8322481 | |
| protection of germ-free mice from infection by helicobacter felis after active oral or passive iga immunization. | helicobacter pylori infection of human gastric epithelium has been associated with gastritis, ulcers and gastric cancers. in an h. felis, germ-free mouse model of infection, oral immunization with bacterial antigens plus cholera toxin resulted in elevated serum, gastric and intestinal anti-h. felis antibody titres and protection from acute infection. mice given monoclonal iga anti-h. felis antibody at the time of initial challenge were also protected from infection. these results demonstrate tha ... | 1993 | 8322486 |
| helicobacter pylori: a cause of chronic abdominal pain in children. | approximately one in ten children are seen by a health care professional for a complaint of chronic recurrent abdominal pain. in most cases these complaints are non-organic. organic causes of abdominal pain may include gastroesophageal reflux, peptic ulcer disease, gallbladder, pancreatic or kidney disease. in addition, infection of the gastric antrum with helicobacter pylori is now included in the differential diagnosis of chronic abdominal pain in children. h. pylori are "s" or "c" shaped, gra ... | 1993 | 8323993 |
| rapid test for detection of antibodies to helicobacter pylori. | 1993 | 8324158 | |
| [oral triple therapy for eradication of helicobacter pylori in duodenal ulcer disease]. | 25 patients with helicobacter pylori-associated active duodenal ulcer disease (bleeding: n = 5, penetrating: n = 1, stenosis of the bulb: n = 4, frequent ulcer relapse: n = 18) were treated with 3 x 600 mg bismuth subsalicylate (bss), 3 x 400 mg metronidazole and 3 x 500 mg tetracycline in addition to 300 mg ranitidine. 23 out of 25 patients (92%) proved to be helicobacter pylori-negative four weeks after cessation of study medication as judged from negative urease test, specific culture and his ... | 1993 | 8326916 |
| the us temporal and geographic variations of diseases related to helicobacter pylori. | if helicobacter pylori plays an important role in the occurrence of three distinct diseases--gastric cancer, gastric ulcer, and duodenal ulcer--their individual epidemiologic behaviors should show a resemblance to one common pattern. | 1993 | 8328594 |
| epidemiology of helicobacter pylori: the indian scenario. | to compare the age-related prevalence of helicobacter pylori in populations from developing and developed nations to determine the possible mode of transmission. | 1993 | 8330925 |
| identification of helicobacter pylori dna in the mouths and stomachs of patients with gastritis using pcr. | to determine the prevalence of helicobacter pylori colonisation in the mouths of patients with h pylori gastritis. | 1993 | 8331177 |
| effect of helicobacter pylori infection on intragastric urea and ammonium concentrations in patients with chronic renal failure. | to assess the value of measuring the gastric juice urea:ammonium ratio in detecting helicobacter pylori infection in patients with chronic renal failure. | 1993 | 8331178 |
| effect of transport medium and transportation time on culture of helicobacter pylori from gastric biopsy specimens. | to determine whether transportation time and use of a low budget transport medium (nacl 0.9%) would influence culture of helicobacter pylori from gastric biopsy specimens, upper gastrointestinal endoscopy was performed on 42 patients. the specimens were cultured and examined histologically, and h pylori antibodies were determined using an elisa technique. patients were regarded as h pylori positive when culture was positive or when histology or igg anti-h pylori antibodies indicated h pylori inf ... | 1993 | 8331182 |
| clarithromycin for the eradication of helicobacter pylori. | helicobacter pylori infection has proven to be extraordinarily difficult to eradicate. antimicrobial monotherapies have been particularly disappointing, with most eradication rates in the range of 0-15%. clarithromycin has potential advantages over other macrolides to which h. pylori is susceptible because of its acid stability and solubility at low ph. we evaluated clarithromycin therapy (250 mg four times daily for 14 days) in 12 h. pylori-infected patients. the 13c-urea breath test was used t ... | 1993 | 8331260 |
| aflagellated mutants of helicobacter pylori generated by genetic transformation of naturally competent strains using transposon shuttle mutagenesis. | three out of 10 helicobacter pylori clinical isolates were found to be naturally competent for genetic transformation to streptomycin resistance by chromosomal dna extracted from a spontaneous streptomycin-resistant h. pylori mutant. the frequency of transformation varied between 5 x 10(-4) and 4 x 10(-6), depending on the h. pylori isolate used. transposon shuttle mutagenesis based on this natural competence was established using the flagellin gene flaa as the target. the cloned flaa gene was i ... | 1993 | 8332066 |
| immune suppressive effects of helicobacter pylori on human peripheral blood mononuclear cells. | helicobacter pylori, the causative agent of type-b gastritis and duodenal ulcer in man is described as a bacterium able to stimulate the human immune system. this study demonstrates that h. pylori besides this property possesses an immune suppressive activity. the in vitro proliferation of human peripheral blood mononuclear cells to purified protein derivative of tuberculin (ppd), phytohemagglutinin, and concanavalin a was reduced in a dose-dependent manner by bacteria which had been inactivated ... | 1993 | 8332102 |
| helicobacter pylori in renal transplant recipients. | an unselected group of 33 renal transplant recipients were examined by upper gastrointestinal endoscopy at between two and four months after transplantation. all abnormal lesions were documented and biopsied and, in addition, random biopsies were obtained from the gastric antrum and from the first part of the duodenum. the biopsies were examined and graded for gastritis and duodenitis and the presence of helicobacter pylori was noted. duodenitis was identified in 16 patients and gastritis in 10; ... | 1993 | 8333032 |
| antibiotic therapy alone eradicates helicobacter pylori and prevents duodenal ulcer recurrence. | 1993 | 8335215 | |
| sequence of the proteus mirabilis urease accessory gene ureg. | we report the sequence of ureg, an accessory gene that is a part of the ure gene cluster of uropathogenic proteus mirabilis and required for full enzymatic activity of urease. the 615-bp open reading frame predicts a m(r) 22,374 polypeptide, which contains a consensus amino acid (aa) sequence for atp-binding. the polypeptide shares sequence homology with ureg of escherichia coli (93% of identical aa), klebsiella aerogenes (59%) and helicobacter pylori (59%). | 1993 | 8335248 |
| an uncultured gastric spiral organism is a newly identified helicobacter in humans. | "gastrospirillum hominis" is an uncultivated spiral bacterium in human gastric mucosa that is larger and more tightly coiled than helicobacter pylori. in an attempt to determine if this organism is a new species of helicobacter, its 16s rrna gene was cloned and sequenced. gastric mucosa from 2 patients infected with "gastrospirillum hominis" was fed to specific pathogen-free mice. electron microscopy of gastric tissue confirmed that the mice became colonized with "gastrospirillum hominis." the 1 ... | 1993 | 8335974 |
| histamine content of the oxyntic mucosa from duodenal ulcer patients: effect of helicobacter pylori eradication. | the histamine concentration of the oxyntic mucosa was determined in helicobacter pylori-positive patients with duodenal ulcer before and after antimicrobial therapy and in h. pylori-negative subjects. determination of serum gastrin was also performed in duodenal ulcer patients before and after h. pylori eradication. the histamine content of the oxyntic mucosa was lower in patients with duodenal ulcer than in h. pylori-negative subjects, but it increased after h. pylori eradication. conversely, i ... | 1993 | 8338090 |
| apparent reversal of early gastric mucosal atrophy after triple therapy for helicobacter pylori. | helicobacter pylori may be difficult to detect in individuals with intestinal metaplasia or atrophic gastritis, even though bacteria may persist in the mucosa in low numbers, maintaining elevated serum h. pylori antibody levels. we report a patient with marked, endoscopically visible gastric mucosal changes and focal changes of histological atrophic gastritis, who was negative for h. pylori on urease test, culture, and histology, but had positive h. pylori serology. when treated with triple ther ... | 1993 | 8338096 |
| low prevalence of helicobacter pylori in the acquired immunodeficiency syndrome. | 1993 | 8338111 | |
| proton-pump inhibitor-refractory gastric ulcer and helicobacter pylori. | 1993 | 8338112 | |
| source of helicobacter pylori infection. | 1993 | 8338115 | |
| [detection of serum igg (elisa) against helicobacter pylori: relationship with age and gastroduodenal disease]. | an attempt was made to investigate the serological response against helicobacter pylori by using a igg serum detection technique (elisa biometra) to establish a relationship with age and gastroduodenal pathology. the serological response was compared with the microbiologic and histologic studies of biopsy samples from 4 locations in each patient: duodenal bulb, gastric antrum, corpus and fundus. | 1993 | 8338704 |
| identification of helicobacter pylori by endoscopic crush cytology. | gastric crush cytology is employed in a variety of situations including diagnosis of malignant disease and the detection of helicobacter pylori infection. | 1993 | 8340141 |
| role of acid inhibition in the management of helicobacter pylori infection: chairmen's introduction. | 1993 | 8341985 | |
| hp and ph: implications for the eradication of helicobacter pylori. | helicobacter pylori infection causes inflammation of the gastric and duodenal mucosae, which results in a disturbance of the regulatory mechanisms for gastrin, gastric acid and pepsin secretion. acid secretion may be decreased, normal or increased, depending on the stage of infection, although the meal-stimulated gastrin response is invariably elevated. the exact mechanisms involved are not known but may be due to the release of cytokines in response to bacterial toxins. h. pylori colonization i ... | 1993 | 8341986 |
| long-term follow-up after eradication of helicobacter pylori with a combination of omeprazole and amoxycillin. | early studies have suggested that omeprazole may facilitate the eradication of helicobacter pylori. sixty patients with duodenal ulcer and h. pylori colonization were randomly assigned to receive either omeprazole monotherapy (n = 30) or combination therapy with omeprazole and amoxycillin (n = 30) for a total duration of 6 weeks. four patients receiving monotherapy and three receiving combination therapy had to be withdrawn from the study. all (100%) duodenal ulcers healed in patients receiving ... | 1993 | 8341987 |
| role of helicobacter pylori in the pathogenesis of gastritis, peptic ulcer and gastric cancer. | helicobacter pylori is the major causal factor in chronic gastritis. its acquisition leads to a chronic, usually lifelong, inflammation of the gastric mucosa, which may gradually progress to atrophy (with intestinal metaplasia) in a significant proportion of infected individuals. this progression is probably multifactorial, being influenced by genetic or environmental factors in addition to h. pylori infection. the pathogenesis of peptic ulcer and gastric cancer is closely associated with h. pyl ... | 1993 | 8341988 |
| compliance, adverse events and antibiotic resistance in helicobacter pylori treatment. | the highest h. pylori eradication rates have been reported with triple therapy, using metronidazole with amoxycillin or tetracycline, and colloidal bismuth subcitrate or bismuth subsalicylate. the use of such therapies, however, may be impeded by a number of major disadvantages, including reduced patient compliance, the incidence of adverse events and primary or acquired antibiotic resistance. patient compliance is a particular problem with triple therapy owing to the quantity of drugs taken, tr ... | 1993 | 8341989 |
| eradication of helicobacter pylori and its effect in peptic ulcer disease. | since helicobacter pylori was first cultured 10 years ago, there have been remarkable changes in our approach to the therapy of peptic ulcer disease. we now know that 90% of duodenal ulcer patients and 70% of all gastric ulcer patients are infected with h. pylori. evidence is presented that the relapse rate of both duodenal and gastric ulcers can be substantially reduced if the bacterium is eradicated from the patient's stomach. some of the anti-h. pylori eradication regimens currently available ... | 1993 | 8341990 |
| gastric syphilis. primary diagnosis by gastric biopsy: report of four cases. | gastric involvement in secondary or tertiary syphilis is rarely recognized clinically, and its diagnosis by examination of endoscopic biopsy specimens has been reported infrequently. we report four cases of gastric syphilis with the primary diagnosis made by gastric biopsy. the patients, all male, ranged in age from 38 to 78 years and presented with gastric complaints, the most common being upper gastrointestinal tract bleeding (three of four). gastroscopy showed either erosive gastritis or gast ... | 1993 | 8343046 |
| acid secretion and sensitivity to gastrin in patients with duodenal ulcer: effect of eradication of helicobacter pylori. | the effect of ulcer healing with eradication of helicobacter pylori (h pylori) on gastric function was investigated in nine patients with duodenal ulcer disease. one month after eradication there were significant reductions in both basal plasma gastrin concentration, from a median (range) of 19 (1-22) to 6 (2-15) pmol/l (p < 0.05), and of basal acid secretion from 8.3 (2.4-24) to 2.6 (1.4-8.1) mm h+/h, (p < 0.01). the peak acid secretion rate was unchanged from 37 (16-59) to 37 (21-59) mm h+/h. ... | 1993 | 8344574 |
| changes in the gastric mucosa following eradication of helicobacter pylori. | although most studies reporting on the examination of helicobacter pylori infection have focused on the clearance of the bacteria and the rapid disappearance of the neutrophil infiltrates, the evolution of inflammatory and architectural changes in the antral and corporal mucosa following the eradication of h. pylori has not been addressed systematically. this study examines in detail the histopathologic appearance of the antral and corporal mucosa in a group of patients infected with h. pylori a ... | 1993 | 8346176 |
| eradication of helicobacter pylori in recurrent duodenal ulcer. | 1993 | 8347229 |