Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| detection of helicobacter pylori by papanicolaou-stained touch imprint: a comparison with histologic examination. | 1993 | 7687822 | |
| a review of diagnostic techniques for helicobacter pylori infection. | the description of helicobacter pylori and an understanding of its pathogenetic significance has been one of the major breakthroughs in gastroenterology in the past decade. because of the possible implications, a correct diagnosis of the infection is mandatory. diagnostic techniques can be divided into invasive and non-invasive methods. the first require upper gastrointestinal endoscopy with a biopsy taken from the stomach. these biopsy specimens can be studied for the presence of h. pylori usin ... | 1993 | 7690313 |
| adhesion of helicobacter pylori to gastric epithelial cells in primary cultures obtained from stomachs of various animals. | of 35 strains of helicobacter pylori tested, 5 were found to adhere well to hep-2 cells. we selected three of these adhesive strains and four from the remaining strains to examine their ability to adhere to gastric epithelial cells in primary cultures obtained by collagenase digestion of stomachs from mice, rats, mongolian gerbils, guinea pigs, pigs, and cynomolgus monkeys. the three adhesive strains adhered well to epithelial cells from monkey and pig gastric antra. the adhesion was inhibited b ... | 1993 | 7691743 |
| serological testing for campylobacteriosis with sera forwarded for salmonella and yersinia serology. | single serum specimens forwarded for salmonella and yersinia serology, from a total of 250 patients, were tested for anti-c. jejuni antibodies of the igg class. anti-salmonella and anti-y. enterocolitica o3 antibodies were examined by a microagglutination test and anti-c. jejuni antibodies by elisa against a c. jejuni ultrasonicate before (elisa) and after neutralization of antibodies which cross-reacted with helicobacter pylori antigens (elisa-abs). blood donor sera (n = 50) and sera (n = 40) f ... | 1993 | 7692894 |
| microbiological aspects of helicobacter pylori infection. | helicobacter pylori colonises the human gastroduodenal mucosa, causes chronic active gastritis, is a co-factor for the development of duodenal ulceration, and is associated with gastric ulceration and gastric cancer. as there are no readily available typing schemes for identification of individual isolates, little is known about the acquisition, distribution and frequency of particular strains of h. pylori in different populations, communities and families. molecular (dna) typing studies carried ... | 1993 | 7693149 |
| the epidemiology of helicobacter pylori: missing pieces in a jigsaw. | gastric colonisation with helicobacter pylori is common throughout the world. although most infected individuals remain well, h. pylori is involved in the pathogenesis of type b gastritis and peptic ulcer disease. there is also an epidemiological association with gastric cancer. person-to-person spread is the most likely form of transmission but it is not clear whether this is faecal-oral or oral-oral. the risk factors for developing disease following infection are poorly understood. the develop ... | 1993 | 7693150 |
| clinical aspects of infection with helicobacter pylori. | about 90% of patients with duodenal ulcer and 65% of those with gastric ulcer are infected with helicobacter pylori. h. pylori infection can be diagnosed by examination of biopsy material obtained at endoscopy; by 14c or 13c-urea breath tests, or by serological means. the relapse rate of duodenal and gastric ulcers can be considerably reduced if the bacteria are eradicated. some of the current treatment regimens are discussed. | 1993 | 7693151 |
| can eradication of helicobacter pylori prevent gastric cancer? gastrointestinal physiology working group of cayetano heredia. | 1993 | 7693426 | |
| rapid detection and characterization of sialic acid-specific lectins of helicobacter pylori. | a particle agglutination assay (paa) using fetuin (ft) covalently coupled to carboxylate-modified latex (cml) particles was evaluated for rapid detection of sialic acid-specific haemagglutinins/lectins (sals) of helicobacter pylori isolates which bind sialoglycoconjugates. sixty-three percent (20/32) of the isolates examined gave a positive paa test. cell-bound sals were extracted by washing the bacteria with deionized water or isotonic saline, and their expression was influenced by ph and cultu ... | 1993 | 7694599 |
| [detection of helicobacter pylori by the urease test in 244 patients]. | the authors report the results of the detection of helicobacter pylori (hp) in gastric mucosa by the urease test, in 244 patients between january 1989 and august 1991. the overall prevalence of hp was 38.1%. it was 19.5% in patients with normal upper gastrointestinal endoscopy (ue), 61% in duodenal ulcer (p < 0.001) and 68.7% in congestive antritis (p < 0.001), significantly higher than in controls. there was no significant difference between controls and patients with erosive antritis or healed ... | 1993 | 7799411 |
| helicobacter pylori and intestinal metaplasia in antral mucosa. a study on their correlation. | to investigate the possible relation between helicobacter pylori (hp) colonization and incidence of intestinal metaplasia (im), antral biopsy specimens from a total of 263 subjects (167 had chronic gastritis, 12 gastric cancer, and 84 no histological changes) were examined. im was observed in 27.7% of the hp positive specimens and in 18.3% of the hp negative biopsies (p = ns). histochemical characterization of mucins showed that the percentage of hp colonization was not significantly different w ... | 1993 | 7761658 |
| [does no helicobacter pylori mean no duodenal ulcer?]. | 1993 | 7779166 | |
| [diagnostic methods in helicobacter pylori infection]. | since their description by marshall and warren now ten years ago, a lot of tests have emerging in order to detect infection by helicobacter pylori. these tests are analyzed in this paper. we divided them in invasive, because they need an endoscopy with biopsy and non invasive with no endoscopy. we inform about the sensitivity and specificity of each one. from the invasive test the histology could be a good alternative for the diagnosis. in order to do epidemiological studies serology is good, an ... | 1993 | 7747032 |
| [helicobacter pylori in patients with diseases of the upper part of the gastrointestinal tract]. | among the patients subjected to esophoagogastroduodenoscopy because of different clinical indications, 108 were examined for the presence of helicobacter pylori in the antral gastric mucosa. microbiological analysis of the antral gastric mucosa biopsies were conducted by direct microscopy, the urease test and by growing in nutritious media. positive findings were recorded in 38 (86.36%) patients with endoscopically diagnosed chronic gastritis, 29 (80.56%) patients with duodenal ulcer and 19 (67. ... | 1993 | 7862044 |
| functional dyspepsia: where do we stand? | despite its high prevalence, our understanding of the pathophysiology and therapy of functional or nonulcer dyspepsia is very limited. because of differences in definition, diagnostic work-up and patient or population characteristics, interpretation of published studies on functional dyspepsia is difficult. recently developed new proposals, such as the role of helicobacter pylori in the pathogenesis and the clinical relevance of dividing dyspeptic patients into subgroups based on clusters of sym ... | 1993 | 7912448 |
| mechanisms involved in helicobacter pylori-induced inflammation. | helicobacter pylori infection is associated with mucosal inflammation. the aims of the present study were to assess whether a water extract of h. pylori promotes neutrophil (polymorphonuclear leukocyte [pmn]) adherence to endothelial cells and define the molecular basis of this adhesive interaction. | 1993 | 7901109 |
| transmission of helicobacter pylori via faeces. | 1993 | 7901696 | |
| helicobacter pylori causes hyperproliferation of the gastric epithelium: pre- and post-eradication indices of proliferating cell nuclear antigen. | to assess the effect of helicobacter pylori (hp) eradication on the proliferation of the gastric epithelium by the expression of the proliferating cell nuclear antigen (pcna). | 1993 | 7901989 |
| effect of helicobacter pylori eradication on antral gastrin- and somatostatin-immunoreactive cell density and gastrin and somatostatin concentrations. | the density of antral gastrin (g)- and somatostatin (d)-immunoreactive cells and the contents of antral gastrin and somatostatin were investigated in endoscopic antral biopsy specimens from patients with duodenal ulcer before and after eradication of helicobacter pylori. after h. pylori eradication both antral somatostatin concentration (p = 0.0002) and antral d-cell density (p = 0.01) increased significantly. conversely, although the number of g-cells was unchanged, antral (p = 0.0002) and seru ... | 1993 | 7903471 |
| [restriction endonuclease (noti) analysis of chromosomal dna of helicobacter pylori by pfge]. | with the goal of differentiating h. pylori in order to clarify its pathogenicity, we have conducted a restriction endonuclease of the chromosomal dna of 24 strains of h. pylori employing the restriction endonucleases, noti, cpoi, kpni, and smai using pulsed-field gel electrophoresis (pfge). with noti, these 16 strains out of 24 strains were completely digested, and 16 clearly different electrophoretic patterns of noti digested chromosomal dna fragments were seen, permitting us to successfully di ... | 1993 | 7904319 |
| [polymorphism of helicobacter pylori urease genes and gastric diseases]. | helicobacter pylori (hp) is now recognized as a major etiologic agent of chronic gastritis and peptic ulcer and is recently presumed to be a cofactor in the occurrence of gastric cancer. hp has a high urease activity, which possibly plays a role in the pathogenesis of gastroduodenal diseases. in this paper, the function and the genetic structure of hp urease gene and the restriction fragment length polymorphism (rflp) among hp strains using a probe of hp urease alpha subunit gene were described. ... | 1993 | 7904320 |
| [the role of eradication of helicobacter pylori in healing and recurrence of gastric ulcer]. | it is now generally accepted that infection with helicobacter pylori is the most common cause of active chronic gastritis and duodenal ulceration. although h. pylori is detected in the majority of patients with gastric ulcer, its pathogenicity and role in gastric ulceration remains unclear. one method to study this relationship is to eradicate h. pylori and observe the recurrence of gastric ulcer. in the present paper we examined the consequence of h. pylori eradication by antibiotics mono thera ... | 1993 | 7904321 |
| serum levels of pepsinogen i in healthy volunteers and patients with gastric ulcers and gastric carcinoma in taiwan. | in order to investigate the clinical usefulness of human pepsinogen i (pgi) as a noninvasive diagnostic tool for gastric lesions, 92 healthy volunteers, 87 patients with a gastric ulcer and 94 patients with gastric carcinoma, verified by histologic examinations, were enrolled. the serum level of pgi in each patient was measured by radioimmunoassay. mean serum pgi levels were 95.4 +/- 39.4 ng/ml in patients with gastric ulcers, 77.6 +/- 29.3 ng/ml in healthy volunteers, and 52.1 +/- 26.5 ng/ml in ... | 1993 | 7904845 |
| eradication of helicobacter pylori infection and the recurrence of duodenal ulcers. | the purpose of this study was to compare the performance of different regimens on helicobacter pylori (h. pylori) eradication and duodenal ulcer recurrence. during a four-week period, 59 patients with duodenal ulcers who were positive for h. pylori infection were randomly treated with one of three regimens. seventeen patients were treated with ranitidine, 19 with colloidal bismuth subcitrate (cbs), and 23 with triple therapy (cbs, tetracycline and metronidazole). forty-six patients with healed u ... | 1993 | 7904847 |
| local and systemic immune response in helicobacter pylori-associated chronic gastritis before and after treatment. | ten patients with helicobacter pylori-associated chronic gastritis were given combination therapy for 6 weeks with a bismuth subnitrate-containing compound and bacampicillin. the eradication rate was 40% 6 weeks after the end of treatment. two patients remained h. pylori-negative at long-term follow-up after 6 and 17 months; that is, h. pylori was only eradicated in 20% of the patients after long-term observation. by dot blot and immunoblotting both urease and an urease-associated heat shock pro ... | 1993 | 7905661 |
| [advances in gastrointestinal peptides: somatostatin]. | twenty years after being identified as "somatotropin release inhibiting factor" (srif) and "growth-hormone release inhibiting hormone" (gh-rih), under a new name, somatostatin (sms) has reached an outstanding position in gastroenteropancreatic endocrinology. it is a powerful and universal inhibitor of the digestive functions: secretion, motility, absorption and splanchnic blood flow. long-acting synthetic analogues have made possible its therapeutic trial in certain clinical problems. this revie ... | 1993 | 7910493 |
| molecular cloning of helicobacter pylori dna: important differences between mcrbc deletion host strains. | 1993 | 7934864 | |
| helicobacter pylori and acid secretion. | helicobacter pylori has been implicated in the aetiopathogenesis of peptic ulcer but data on the effect of infection by this organism on gastric acid secretion are equivocal. we, therefore, examined the effect of the presence of helicobacter pylori in the antrum and body of the stomach on acid secretion. | 1993 | 7950929 |
| helicobacter pylori prevalence in northeastern thailand. | helicobacter pylori is distributed worldwide and has been demonstrated in thailand. however, no study has been conducted so far in northeastern thailand. the objective of this study was to find the prevalence of h. pylori in patients undergoing upper gastrointestinal endoscopy in northeastern part of thailand. one hundred and twenty-six patients undergoing surgery between november 1992 and january 1993 were studied. biopsies were done at antrum, corpus, and other positive lesions. diagnostic tes ... | 1993 | 7939950 |
| [the isolation of helicobacter pylori from the gastric juice]. | gastric contents was examined in 49 patients with duodenal bulb ulcers. helicobacter pylori were isolated in 83.7% of cases. h. pylori density was found to be 10(3)-10(5) microbial cells per ml. bacterioscopic studies with gram staining helped detect h. pylori in 79.6% of cases, cultural method revealed the bacteria in 63.3%, and urease test in 4.1% of cases. poor efficacy of urease test is explained by its poor sensitivity (10(6) microbial cells per ml or higher). the authors analyze the freque ... | 1993 | 7994536 |
| [infection with helicobacter pylori as a risk factor for stomach cancer]. | 1993 | 8008654 | |
| serological examinations in patients with helicobacter pylori infections. | a passive microhemagglutination test was applied for the detection of h. pylori antibodies. the presence of elevated antibody titers was most frequently encountered in the sera of patients from whom h. pylori was isolated. no relationship between the level of antibodies and the clinical picture of peptic ulcer disease was noted. in addition, negative results from bacteriologic and serologic studies in patients with confirmed histopathologic changes and typical clinical symptoms may suggest that ... | 1993 | 8010871 |
| evaluation of three serological tests for the detection of helicobacter pylori associated infection. | biopsy specimens and serum samples from 140 patients with duodenal or gastric ulcer disease were examined. the presence of helicobacter pylori was detected in 105 out of 140 subjects. three testing techniques used in this study led to different results. thus, the enzyme-linked immunosorbent essay enabled detection of elevated igg antibodies to h. pylori in 108 serum samples. passive microhemagglutination and latex agglutination, "pyloriset" led to the detection of elevated titers in 102 and 83 s ... | 1993 | 8010872 |
| attachment of helicobacter pylori to human gastric epithelium mediated by blood group antigens. | helicobacter pylori is associated with development of gastritis, gastric ulcers, and adenocarcinomas in humans. the lewis(b) (le(b)) blood group antigen mediates h. pylori attachment to human gastric mucosa. soluble glycoproteins presenting the leb antigen or antibodies to the leb antigen inhibited bacterial binding. gastric tissue lacking leb expression did not bind h. pylori. bacteria did not bind to leb antigen substituted with a terminal galnac alpha 1-3 residue (blood group a determinant), ... | 1993 | 8018146 |
| antigen profile of helicobacter pylori strains isolated from peptic ulcer patients in dhaka, bangladesh. | the whole-cell-extract and the acid-extract preparations of helicobacter pylori strains isolated from peptic ulcer patients and the nctc 11638 control strain were studied to compare their antigen profiles. besides, the anti-h. pylori-antibody profile in serum from h. pylori-infected peptic ulcer patients were also studied to define the antigen stimulating specific anti-h. pylori-antibody response in the infected patients. the whole-cell extract (wce) and the acid-extract (ae) preparations showed ... | 1993 | 8031286 |
| prevalence of helicobacter pylori infection in patients with peptic ulcer diseases and non-ulcer dyspepsia. | helicobacter pylori is known to be a cause of active chronic gastritis and has been proposed as an etiologic factor in the development of peptic ulcer disease, but controversy continues regarding the pathogenic importance and mechanism. we examined the prevalence of h. pylori infection in patients with peptic ulcers and non-ulcer dyspepsia. | 1993 | 8031726 |
| [tests of helicobacter pylori survival in milk]. | the survival of microaerophilic bacteria helicobacter pylori (hp) isolated from gastric mucosa was studied in 2 ml and 10 ml samples of milk contaminated with a suspension of these bacteria in 20% glucose solution. milk was kept at 5-7 degrees c temperature in refrigerator and at room temperature. hp was found in samples kept at 5-7 degrees c during 3 days. on the other hand, hp was not found after 24-hours keeping at room temperature. | 1993 | 8016539 |
| pathophysiology and treatment of functional dyspepsia. | functional dyspepsia (or 'non-ulcer') is usually defined as chronic or intermittent upper abdominal symptoms for which no organic cause can be found. division of functional dyspepsia into subgroups such as reflux-like, ulcer-like, dysmotility-like and non-specific dyspepsia has been proposed, but lacks a scientific basis. gastric acid hypersecretion, helicobacter pylori-associated gastritis, gastric and small intestinal motor disorders, psychological and neurohormonal factors all might play a ro ... | 1993 | 8016577 |
| [non-ulcer dyspepsia syndrome]. | in one thousand of 1500 examinees with nonulcerous dyspepsia the syndrome was due to chronic gastritis, duodenitis and gastroduodenitis, in five hundred of them it was attributed to probable dysfunction of the upper gastrointestinal tract. morphological evidence of chronic gastritis activity is essential but not the only factor affecting the dyspepsia syndrome. of importance are also motor dysfunctions: high intragastric and/or intraduodenal pressure, unbalance of intracavitary pressure paramete ... | 1993 | 8046898 |
| acid-peptic disease: helicobacter pylori and omeprazole: great advances but clinical problems remain. | 1993 | 8055219 | |
| helicobacter pylori: a primer for 1994. | ten years after the original isolation of helicobacter pylori, we know that this interesting new bacterium infects half of the world's population and at least 25% of people in the united states. the mode of transmission is probably fecal-oral, and its prevalence increases in lower socioeconomic groups or older people. fortunately, the organism can now be diagnosed using serology, breath testing, biopsy, and culture. we also have effective means of therapy in the united states giving 80 to 95% cu ... | 1993 | 8055220 |
| helicobacter pylori: practical guidelines for diagnosis and treatment. | ulcer disease can be cured in most patients. the discovery of an infectious cause of peptic disease has necessitated new diagnostic and treatment strategies for common upper gastrointestinal tract problems. appropriate use of one of the many new tests to diagnose helicobacter pylori can identify those individuals likely to benefit from antimicrobial treatment. further refinement of antimicrobial regimens should ensure better patient compliance and maximize effective bacterial eradication. h. pyl ... | 1993 | 8055226 |
| serological diagnosis of infection by helicobacter pylori in chronic ulcer disease. | the authors estimated the frequency of occurrence of the infection by helicobacter pylori in the long term gastroduodenal ulcer disease. the serological diagnosis (elisa test) was carried out in 175 patients, suffering from this disease for at least two years, to reveal the existence of specific igg against helicobacter pylori. the study confirmed the frequent occurrence of infection by helicobacter pylori in the gastro-duodenal ulcer disease of the stomach (59.2%) and the duodenum (83.7%). it w ... | 1993 | 8072313 |
| [hla, blood group, secretory factor, pepsinogen i, and helicobacter pylori in duodenal ulcer patients]. | duodenal ulcer is a multifactorial entity where a genetic predisposition and extrinsic elements seem to concur in its origin. a series of genetic and extrinsic markers were determined in 50 patients with duodenal ulcer and 50 controls matched by age, sex and socioeconomical status. hla antigens dit not have significant differences. blood group o rh+ was predominant (p < 0.01). secretor status of antigen hbo in saliva was positive in 70% of patients (p < 0.001). serum pepsinogen i was increased i ... | 1993 | 8050704 |
| [the effect of helicobacter pylori on the development of complications in the stomach and duodenum of patients with rheumatic diseases]. | biopsy material of gastric mucosa obtained from 94 patients with rheumatic diseases was subjected to bacterioscopic, biochemical and microbiological studies. helicobacter pylori was found in 29% of patients with rheumatism, in 34.3% of patients with rheumatic arthritis and in 39.9% of those suffering from osteoarthrosis deformans. the study confirms that the microorganisms found in gastric and duodenal mucosa should be considered as a saprophytic microflora which promotes inflammatory process. | 1993 | 8085360 |
| treatment of helicobacter pylori-associated gastroduodenal disease in children. clinical evaluation of antisecretory vs antibacterial therapy. | the charts of 54 children diagnosed with antral h. pylori were reviewed, to establish the incidence of gastroduodenal inflammation and compare therapeutic efficacies of antisecretory vs. antibacterial therapy. histology demonstrated normal mucosa in three cases (6%) and gastric/duodenal inflammation (> or = whitehead grade 3) in 51 biopsies (94%). 23/43 children (53%) initially responded to h2-blockers; however, by 10 mo, 13 had relapsed clinically. all of these patients subsequently responded t ... | 1993 | 8093598 |
| helicobacter pylori in dental plaque. | 1993 | 8094153 | |
| pcr identification of helicobacter pylori in faeces from gastritis patients. | 1993 | 8094221 | |
| uncomplicated peptic ulcer disease. an overview of formation and treatment principles. | the end point in peptic ulcer disease is a crater in the mucosa. the cause of gastric ulcers seems to be the breakdown of defensive factors, which then allows damage from endogenous and/or exogenous aggressive factors. aggressive factors are more important in duodenal ulcer formation. treatment options discussed herein have similar clinical effectiveness, and all have better results than placebo. selection of a specific agent should be individualized. helicobacter pylori infection has been impli ... | 1993 | 8095330 |
| refractory peptic lesions. therapeutic strategies for ulcers and reflux esophagitis that resist standard regimens. | in some patients, peptic lesions fail to heal after 2 to 3 months of standard histamine2 (h2) receptor antagonist or sucralfate (carafate) therapy. noncompliance with prescribed treatment, cigarette smoking, gastric acid hypersecretory states (including zollinger-ellison syndrome), helicobacter pylori infection, the use of nonsteroidal anti-inflammatory drugs, abdominal radiation therapy, and malignant tumors are all causes of refractory disease. treatment options include high-dose h2 receptor a ... | 1993 | 8095331 |
| the impact of therapeutic improvements in reducing peptic ulcer mortality in europe. | trends in death certification rates from peptic ulcer between 1955 and 1989 have been analysed for 24 european countries on the basis of age-specific and age-standardized rates, and a log-linear model to estimate the effects of age, cohort of birth and period of death. for males, in all western countries there were substantial declines in mortality. in the late 1950s, the range of variation of the world standardized rates was between 4/100,000 in france and 17.8 in portugal. in the late 1980s, o ... | 1993 | 8095492 |
| helicobacter pylori and pathogenesis of ulceration. | 1993 | 8095617 | |
| helicobacter pylori and pathogenesis of ulceration. | 1993 | 8095619 | |
| detection of helicobacter pylori dna by pcr in gastrointestinal equipment. | 1993 | 8096604 | |
| helicobacter pylori: host responses in peptic ulceration. | 1993 | 8096606 | |
| helicobacter pylori and duodenal ulcer disease: the somatostatin link? | 1993 | 8097735 | |
| detection of vacuolating toxin of helicobacter pylori in human faeces. | 1993 | 8098476 | |
| an international association between helicobacter pylori infection and gastric cancer. the eurogast study group. | gastric infection with helicobacter pylori seems to be a risk factor for gastric cancer. we have conducted a multicentre epidemiological study to investigate this relation further. our study was designed to look at the relation between the prevalence of h pylori infection and gastric cancer rates in 17 populations from 13 countries, chosen to reflect the global range of gastric cancer incidence. in each centre, about 50 males and 50 females in each of the two age groups 25-34 years and 55-64 yea ... | 1993 | 8098787 |
| categorization of clinical isolates of helicobacter pylori on the basis of restriction digest analyses of polymerase chain reaction-amplified urec genes. | restriction endonuclease analyses of a 1.1-kb polymerase chain reaction-amplified portion of the urec gene from helicobacter pylori were used to group or to differentiate 21 clinical isolates. isolates were placed into 4 groups after hindiii digestion alone, and placement was expanded into 15 groups after isolates were digested with alui and pvui. | 1993 | 8099088 |
| abdominal lymph-node granulomas and helicobacter pylori. | 1993 | 8100033 | |
| peptic ulcer disease: an update. | peptic ulcers can develop when there is an imbalance between gastric acid secretion and gastroduodenal mucosal defense. investigators are looking at the role of helicobacter pylori in the development of peptic ulcer disease; eradication of the microorganism may reduce recurrence. approved drug therapy includes h2-receptor antagonists, omeprazole, sucralfate, and antacids. recommendations for treating and counseling patients are provided. | 1993 | 8100116 |
| rapid fingerprinting of helicobacter pylori by polymerase chain reaction and restriction fragment length polymorphism analysis. | a simple and reliable technique was developed for differentiating helicobacter pylori strains by restriction fragment length polymorphism analysis of polymerase chain reaction (pcr)-amplified dnas. oligonucleotide primer pairs developed to the urease, 48-kda stress protein (htra), and 26-kda antigen-encoding genes were used to amplify fragments of the appropriate size from crude boiled cell preparations. the pcr-amplified products were digested with sau3a, haeiii, mspi, alui, mlui, hinfi, and xb ... | 1993 | 8100240 |
| differentiation between isolates of helicobacter pylori by pcr-rflp analysis of urease a and b genes and comparison with ribosomal rna gene patterns. | genetic diversity amongst 21 human gastric isolates of helicobacter pylori was investigated by polymerase chain reaction amplification and haeiii digest (restriction fragment length polymorphism) analysis of an internal 2.4-kb segment of the urease a and urease b genes. h. pylori from 11 independent individuals yielded nine distinct restriction fragment patterns but only one pattern was common to h. pylori from two individuals. by contrast, multiple isolate sets of h. pylori from two patients ea ... | 1993 | 8100546 |
| international association between helicobacter pylori and gastric cancer. | 1993 | 8100891 | |
| protection by human milk iga against helicobacter pylori infection in infancy. | 1993 | 8100892 | |
| abdominal lymph-node granulomas and helicobacter pylori. | 1993 | 8101316 | |
| abdominal lymph-node granulomas and helicobacter pylori. | 1993 | 8101317 | |
| seroconversion for helicobacter pylori. | the prevalence of helicobacter pylori antibodies increases with age, but it is unknown whether this is due to a constant rate of infection in different age groups, or whether most infection occurs in childhood. follow-up data on infection rates and the course of infection in an untreated population are scarce. we measured h pylori igg antibody concentrations in patients who were seen at our endoscopy unit between 1979 and 1983. 115 of 164 eligible patients (70%) participated in the study. h pylo ... | 1993 | 8101585 |
| eradication of helicobacter pylori in patients with non-ulcer dyspepsia. | non-ulcer dyspepsia is an unsatisfactory term, as it describes a spectrum of conditions. the term is used for patients who have a normal upper endoscopy, macroscopically, but who have persistent upper gastrointestinal symptoms. patients with non-ulcer dyspepsia respond to a wide variety of treatments, and there is a strong placebo response. fifty per cent of these patients are shown to have helicobacter pylori present if biopsy specimens are taken at endoscopy. previous studies suggest that h. p ... | 1993 | 8102009 |
| gastric cancer and helicobacter pylori: the whispering killer? | 1993 | 8102661 | |
| malaria and the natural history of helicobacter pylori infection. | 1993 | 8102682 | |
| the response of cells from low-grade b-cell gastric lymphomas of mucosa-associated lymphoid tissue to helicobacter pylori. | an association has been shown between colonisation of gastric mucosa by helicobacter pylori, acquisition of mucosa-associated lymphoid tissue (malt), and occurrence of primary b-cell gastric malt lymphoma. we investigated the immunological response of cells from 3 low-grade primary b-cell gastric malt lymphomas to h pylori type nctc 11637 and 12 isolates of h pylori from patients without lymphomas. after co-culture of tumour cells with bacteria, cells were examined for phenotypic evidence of act ... | 1993 | 8102718 |
| regression of primary low-grade b-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of helicobacter pylori. | certain features of primary low-grade b-cell gastric lymphoma of mucosa-associated lymphoid tissue (malt) suggest the tumour is antigen-responsive. given the close association between gastric malt lymphoma and helicobacter pylori, these organisms might be evoking the immunological response, and eradication of h pylori might inhibit the tumour. 6 patients in whom biopsies showed histological and molecular-genetic evidence of low-grade gastric b-cell malt lymphoma with h pylori infection were trea ... | 1993 | 8102719 |
| role of helicobacter pylori in the pathogenesis of complications of meckel's diverticula. | to assess the possible role of colonisation of ectopic gastric mucosa in meckel's diverticula by helicobacter pylori in causing inflammation, ulceration, perforation and bleeding. | 1993 | 8102893 |
| quality of healing in peptic ulcer disease--are h2 receptor antagonists all we need? | the rapid relief of symptoms and ulcer healing can now be achieved in most patients with peptic ulcer. histamine2 (h2) receptor antagonists, proton pump inhibitors, prostaglandin analogues, colloidal bismuth and sucralfate have all proved safe and effective for the initial treatment of peptic ulcer. however, most ulcers will recur when treatment is stopped. meta-analyses suggest a higher relapse rate after h2 antagonist therapy than that following sucralfate or bismuth. this difference has not b ... | 1993 | 8103021 |
| dna fingerprints of helicobacter pylori from mouth and antrum of patients with chronic ulcer dyspepsia. | 1993 | 8103866 | |
| gastric cancer and helicobacter pylori. | 1993 | 8105232 | |
| the hsp60 protein of helicobacter pylori: structure and immune response in patients with gastroduodenal diseases. | helicobacter pylori is a human pathogen that has been associated with gastritis, peptic ulcer and gastric carcinoma. the role of the direct action of h. pylori virulence factors and of the induction of autoreactive immunity in the development of chronic gastritis has not been clarified yet. here we report the cloning and molecular characterization of a gene of h. pylori coding for a protein of 58 kda, recognized by sera of patients affected by h. pylori-induced gastroduodenal diseases. this anti ... | 1993 | 8105364 |
| [exudative enteropathy and gastritis caused by helicobacter pylori in children]. | 1993 | 8053778 | |
| [helicobacter pylori infections in various groups of patients at a general hospital and in blood donors]. | incidence of helicobacter pylori (hp) infection in inpatients of a general hospital and donors was evaluated immunologically: the serum was examined for igg antibodies to hp using enzyme immunoassay. of 354 examinees 89 had duodenal ulcer (du), 101 were healthy donors. hp infection was found prevalent in all the groups of the inpatients. cases of hp were more numerous in the gastroenterological department as compared to other departments (81.6% against 39.6%, respectively). among patients of the ... | 1993 | 8015214 |
| diarrhoeal disease: current concepts and future challenges. malnutrition and infection. | in individual children in developed countries it is possible to follow a sequence of infection of the gastrointestinal tract leading to chronic diarrhoea which, if it long persists, may in turn lead to undernutrition. both in individuals and epidemiologically in developing countries it is, by contrast, often difficult to be certain whether infection precedes under-nutrition or vice versa. chronic diarrhoea is heterogeneous and aetiology varies from community to community. unlike acute diarrhoea, ... | 1993 | 8108842 |
| helicobacter pylori in portal hypertension. | 1993 | 8114266 | |
| autogenous vaccination against helicobacter pylori. | 1993 | 8115933 | |
| helicobacter pylori: enough to give anyone an ulcer! | since the early 1980s, research into gastritis and peptic ulcer disease has been dominated by helicobacter pylori. this is a small, gram-negative spiral bacterium which inhabits the mucus layer that coats the gastric mucosa. colonisation of the human stomach by this bacterium is worldwide and, in certain continents, virtually ubiquitous. while histological gastritis is always the result, h. pylori-positive individuals are characteristically asymptomatic. transmission is thought to be via the fae ... | 1993 | 8117558 |
| helicobacter pylori infection in early and advanced gastric adenocarcinoma: a seroprevalence study in 143 taiwanese patients. | the association between gastric adenocarcinoma and helicobacter pylori infection remains controversial. a seroprevalence study of helicobacter pylori infection in 143 patients with gastric adenocarcinoma and a control group of 823 subjects randomly selected from four areas in taiwan, was carried out to elucidate the association. the overall seropositivity of helicobacter pylori in gastric adenocarcinoma patients (62.9%) was higher than in controls (54.4%), but the difference was not statisticall ... | 1993 | 8119647 |
| serum levels of pepsinogen i and gastrin in gastric carcinoma: the influence of helicobacter pylori infection and tumor characteristics. | the influence of helicobacter pylori infection on serum levels of pepsinogen i and gastrin in gastric carcinoma was investigated by simultaneous determination of serum pepsinogen i, gastrin, and igg antibodies against helicobacter pylori in 100 patients with gastric carcinoma, and in another 100 age- and sex-matched healthy controls. serum pepsinogen i level was significantly lower in gastric carcinoma than in controls (55.5 +/- 28.1 vs. 76.9 +/- 25.1 ng/ml, p < 0.005), but there was no differen ... | 1993 | 8119648 |
| glucose utilization and lactate production by helicobacter pylori. | the transport and incorporation of d-glucose into the human pathogen helicobacter pylori was investigated employing radioactive tracer analysis and 1h and 13c nuclear magnetic resonance spectroscopy. the bacterium was found to utilize d-glucose contrary to the accepted view that it cannot catabolize carbohydrates. under the experimental conditions employed, the rate of transport of [14c]glucose was 3.24 mmol min-1 (g protein)-1, and the rate of incorporation into the cellular mass was 1.06 mumol ... | 1993 | 8126428 |
| identification of structures containing polyphosphate in helicobacter pylori. | for the first time polyphosphate (poly p) granules have been detected in helicobacter pylori organisms colonizing the gastric antrum as well as in organisms isolated from the same tissue. poly p granules showed typical sublimation characteristics during exposure to the electron beam and chipped out of ultrathin sectioning. a prominent phosphorus signal was identified using elemental specific electron microscopy such as electron energy loss spectroscopy (eels) and was localized to at least three ... | 1993 | 8126429 |
| inhibition of helicobacter pylori glycosulfatase activity towards human gastric sulfomucin by a gastroprotective agent, sulglycotide. | 1. a glycosulfatase activity towards human gastric sulfomucin was identified in the extracellular material elaborated by helicobacter pylori, a pathogen implicated in the etiology of gastric disease. 2. the purified enzyme displayed an apparent molecular weight of 30 kda, and exhibited maximum activity at ph 5.7 in the presence of 0.3% triton x-100 and 100 mm cacl2. 3. the h. pylori glycosulfatase activity towards human gastric sulfomucin was inhibited by a gastroprotective agent, sulglycotide. ... | 1993 | 8112521 |
| helicobacter pylori lipopolysaccharide inhibition of gastric mucosal laminin receptor: effect of sulglycotide. | 1. the effect of cell-wall lipopolysaccharide from helicobacter pylori, a bacterium implicated in the etiology of gastric disease, on the gastric mucosal laminin-receptor was investigated. 2. the receptor, isolated from gastric epithelial cell membrane by affinity chromatography on laminin-coupled sepharose, was radioiodinated and incorporated into liposomes which exhibited specific affinity towards laminin-coated surface. 3. the binding of liposomal receptor to laminin-coated surface was inhibi ... | 1993 | 8112522 |
| [the use of urea carbon 14 in breath tests as diagnostic method for helicobacter pylori infections]. | the helicobacter pylori has been indicated as a pathologic agent in the pathogenesis of antral gastritis, gastric and duodenal ulcers and probably in gastric cancer. due to the high incidence of this infection in our place, we decided to look for a diagnostic method quick to perform, sensitive, reliable and no invasive. the breath test of 14c urea, based in the production of urea by the h. pylori, represents this alternative. we have found, using does of 1 microci, a high correlation with the di ... | 1993 | 8112551 |
| [diagnostic criteria of pyloric helicobacter infection in peptic ulcer]. | helicobacter pylori (hp) in 41 patients (10 with stomach ulcer and 31 with duodenum ulcer) was found in gastro-biopsies from the stomach antrum before and after the treatment. the following methods to reveal hp were used: giemsa staining, immunoperoxidase reaction with polyclonal monospecific antibodies against hp, urease rapid test. hp was also revealed in the blood serum by antibodies against hp by means of enzyme immunoassay. electron microscopy was performed in 5 patients and bacteriologic s ... | 1993 | 8122976 |
| helicobacter pylori infection. | 1993 | 8133551 | |
| [anti-gastric antibodies and gastritis in insulin-dependent diabetes in children]. | adult patients with insulin-dependent diabetes mellitus frequently also show gastric disturbances. knowledge of the prevalence of such abnormalities in children with insulin-dependent diabetes and the predictive value of anti-gastric parietal cell antibodies in blood may be of practical importance. | 1993 | 8135606 |
| histology of the mucosa of gastric antrum and body before and after eradication of helicobacter pylori. | 1. helicobacter pylori status and the histology of the antral and oxyntic mucosa were evaluated in 25 patients with duodenal ulcer treated with a triple schedule of furazolidone, metronidazole and amoxicillin, and in 16 patients treated only with cimetidine. 2. before treatment, h. pylori was detected in all patients. one month after treatment with the antimicrobial agents, h. pylori was not found in 18 (72.0%) of 25 patients treated with the triple schedule. in the patients treated with cimetid ... | 1993 | 8136729 |
| [advances in epidemiologic study in helicobacter pylori infection]. | 1993 | 8137417 | |
| [nested-polymerase chain reaction in detection of helicobacter pylori in human dental plaque]. | a nested polymerase chain reaction (n-pcr) for the specific detection of helicobacter pylori (h. pylori) was developed with two primer pairs derived from the urease gene a of h. pylori. the n-pcr was used to detect all 21 h. pylori strains, including 20 clinical isolates and 1 reference strain (nctc 14126), but failed to detect 12 other bacterial species. it was shown that the pcr assay is 100% specific. tenfold serial dilution experiments revealed that n-pcr could detect as little as 0.1 fg dna ... | 1993 | 8143193 |
| [detection of helicobacter pylori in human saliva by using nested polymerase chain reaction]. | epidemiologic studies suggest person to person spread of helicobacter pylori (h. pylori), but the exact mechanism is unknown. spread through oral secretions has been suggested, however, it has proved very difficult to grow the organism from areas outside the stomach. a nested polymerase chain reaction (n-pcr) for the specific detection of h. pylori was developed with two primer pairs (nested primers) derived from the urease gene a of h. pylori. the n-pcr could detect all 21 h. pylori strains, in ... | 1993 | 8143325 |
| spontaneous bile reflux in the elderly. | duodenogastric bile reflux is common in postoperative stomach but has been reported in intact stomachs. spontaneous bile reflux in the elderly has not been studied before. this has been assessed in dyspeptic elderly and young patients. total bile acid (tba) levels and ph were measured in the samples of fasting gastric juice. antral biopsies were taken for histological examination including helicobacter pylori identification. tba levels were significantly higher in elderly patients with gastritis ... | 1993 | 8144049 |
| [helicobacter pylori at hospital santo tomás]. | we studied the incidence of infection with helicobacter pylori in panamanians with chronic dyspepsia, gastric or duodenal ulcer, gastritis or gastric cancer. the histopathology was positive in 54 (81%) of 66 patients; the urea test was positive in 52 (82.5%) of 63 cases; the impromptu was positive in 51 (79.6) of 64 patients; the endoscopic examination was positive in 64 (82.9%) of 77 examinations. | 1993 | 8146351 |