Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| gastric intestinal metaplasia in ethnic groups in the southwestern united states. | the incidence of gastric cancer has declined dramatically in the united states during this century. however, the incidence of gastric cancer among hispanics, blacks, and native americans remains 2-3-fold higher than among whites in this country. populations with an increased risk of gastric cancer have predominantly the "intestinal" type of gastric cancer, and intestinal metaplasia is regarded as a histological precursor lesion of this type of gastric cancer. we sought to establish the prevalenc ... | 1992 | 1303129 |
| colloidal bismuth subcitrate in non-ulcer dyspepsia. | the effect of colloidal bismuth subcitrate (de-nol) on symptoms, helicobacter pylori status and histological features was studied in 35 patients with non-ulcer dyspepsia. pain (34 cases) and gas bloat (18) were the predominant symptoms. h pylori was present in 26 (74.3%) patients. gastritis and duodenitis were present in 29 of 32 and 22 of 31 cases respectively in whom biopsies were available. relief in symptoms after treatment was seen in 29 (82.8%) cases. improvement in gastritis and duodeniti ... | 1992 | 1303406 |
| [non ulcer dyspepsia, endoscopic gastritis and helicobacter pylori]. | we studied 33 patients with non ulcer dyspepsia and endoscopic gastritis. 21 were female (63.4%) and 12 male (36.4%). helicobacter pylori (hp) was investigated by gastric mucosal biopsy. urease test, gram, culture, and histology were performed in all and two or more of these test hat to be positive to consider hp infection. 16/33 resulted hp positive (48.8%). erosive gastritis was most commonly associated with h.p. infection (62.5%). this was statistically significant. in all the cases hp positi ... | 1992 | 1305113 |
| helicobacter pylori infection in children. | 1992 | 1305650 | |
| risk factors for stomach cancer in sixty-five chinese counties. | stomach cancer mortality data were compared with dietary and biochemical data from 65 chinese counties to provide clues to reasons for the marked geographic variation of stomach cancer mortality rates in china. sex-specific correlation and multivariate regression analyses showed significant positive associations with consumption of salted vegetables and eggs, prevalence of antibodies to helicobacter pylori, and levels of plasma albumin; and significant negative associations with intake of green ... | 1992 | 1306092 |
| comparison of three different methods for evaluation of helicobacter pylori (h.p.) in human dental plaque. | helicobacter pylori (h.p.) is a microorganism involved in peptic ulcer disease. to clarify the role of human dental plaque as a reservoir of h.p. and to compare different methods of investigation the authors studied 20 patients, 17 males main age 56 +/- 12 and 3 females 52 +/- 7, gastro-duodenal h.p. positive. the trial was carried out by cultural, biochemical and microscopical plaque analysis. cultural and microscopical method were h.p. positive in 80% patients, urease in 100%, alkaline phospha ... | 1992 | 1307023 |
| helicobacter pylori, chronic gastritis and peptic ulcer. | h. pylori infection is strongly associated with chronic gastritis and is probably the main course of chronic inflammation in the gastric mucosa. acquisition of the infection will lead to gastritis and the eradication of the bacterium results in healing and final cure of the gastritis. chronic gastritis and h. pylori infection may occur in antrum and/or corpus, and will gradually result in atrophy of the underlying mucosa in a great number of affected persons. correspondingly, impairments in seve ... | 1992 | 1307646 |
| helicobacter pylori in experimental acute and chronic gastric and duodenal ulcer in buffalo [correction of bufallo] rats. | the experiment was performed using inbred buffalo rats to confirm the coincidence between peptic, gastric and duodenal ulcer and helicobacter pylori infection. the results suggest an unquestionable meaning of helicobacter pylori appeared to be as strong ulcerogenic factor in rats as ligation of pylorus and diffusely administrated histamine. | 1992 | 1308048 |
| [acid-peptic disease associated with helicobacter pylori in children. report of a case]. | 1992 | 1308293 | |
| [usefulness of the 14c-urea marked test in the detection of helicobacter pylori in patients with dyspepsia]. | this study was undertaken to evaluate the usefulness of the urea test (ut) in the detection of helicobacter pylori (hp) in dyspeptic patients. the ut was done in 105 patients with dyspepsia who underwent endoscopy and biopsy. hematoxylin-eosin and warthin starry tissue stains were performed for hp detection, and the resulting microscopic findings were considered as the gold standard. the sensitivity, specificity, and positive and negative predictive values of the ut were of 95%, 63%, 85% and 83% ... | 1992 | 1308296 |
| use of polymerase chain reaction-amplified helicobacter pylori urease structural genes for differentiation of isolates. | helicobacter pylori has been demonstrated as an etiologic agent of human gastritis and peptic ulcer formation. however, there is no straightforward basis to distinguish different isolates. we used the polymerase chain reaction (pcr) to amplify the urease structural subunit genes, urea and ureb, which, when digested with appropriate restriction endonucleases, allow the differentiation of patterns on agarose gels. pcr amplification was possible with dna rapidly extracted from h. pylori by alkaline ... | 1992 | 1313051 |
| expression of helicobacter pylori urease genes in escherichia coli grown under nitrogen-limiting conditions. | helicobacter pylori produces a potent urease that is believed to play a role in the pathogenesis of gastroduodenal diseases. four genes (urea, ureb, urec, and ured) were previously shown to be able to achieve a urease-positive phenotype when introduced into campylobacter jejuni, whereas escherichia coli cells harboring these genes did not express urease activity (a. labigne, v. cussac, and p. courcoux, j. bacteriol. 173:1920-1931, 1991). results that demonstrate that h. pylori urease genes could ... | 1992 | 1313413 |
| biotypes and dna fingerprints of cytotoxigenic helicobacter pylori from patients with gastritis and peptic ulceration in italy. | variations in biotypic and dna characteristics of 21 strains of helicobacter pylori from patients in central italy with histologically defined gastritis and/or peptic ulcers were studied. the strains had the same preformed enzyme biotype but differed in motility and cytotoxigenic activity. the presence or absence of these two characteristics were closely associated in 73% of strains and were used to define three phenotypic subsets. strains of subset 1 (mot+ tox+) were most common (52%) particula ... | 1992 | 1315293 |
| new look at chronic gastritis. | chronic gastritis (cg) is classified as type a (autoimmune) and type b [bacterial-helicobacter pylori (hp)]. even type a gastritis is initiated by hp (despite its low incidence in the gastric mucosa), as the incidence of antibodies against hp (anti-hp) in sera of patients with pernicious anemia (pa) is high. anti-hp cross react with gastric mucosal antigens, including alpha and beta subunits of the proton pump (parietal cell antigen) and determine the damage in fundus-body and/or antral mucosa. ... | 1992 | 1318891 |
| construction of isogenic urease-negative mutants of helicobacter pylori by allelic exchange. | isogenic urease-negative mutants of helicobacter pylori were constructed by allelic replacement. a region of cloned h. pylori dna containing the structural urease genes (urea and ureb) was disrupted by insertion of a mini-tn3-km transposon. electrotransformation of h. pylori cells with kanamycin-ureb-disrupted derivative plasmids resulted in isolation of kanamycin-resistant h. pylori transformants. competence for electrotransformation appeared to be restricted to certain wild-type h. pylori isol ... | 1992 | 1320607 |
| helicobacter pylori and gastroduodenal disorders. | 1992 | 1334317 | |
| endogenously formed n-nitroso compounds and nitrosating agents in human cancer etiology. | humans are exposed to preformed n-nitroso compounds (noc), but also to a wide range of precursors and nitrosating agents which can react in vivo to form potentially carcinogenic noc and diazo compounds. nitrite, nitrate and nitrosating agents can also be synthesized endogenously in enzymic reactions mediated by bacteria, activated macrophages and neutrophils. the latter two cell types generate, via the enzyme nitric oxide synthase, the nitric oxide radical that is involved in cytotoxicity, and i ... | 1992 | 1339085 |
| a low cost method to produce a gaseous environment for the isolation of helicobacter pylori. | a low cost method (lcm) to produce a gaseous environment for the isolation of helicobacter pylori, was compared with the standard gas park system. the lcm uses a carbonated antacid tablet, a plastic bag with tap water, a candle, and a wide-mouthed glass jar provided with a tight-fitting metallic screw cap and a rubber gasket. antral gastric biopsies from 153 cases were incubated by duplicate on blood agar plates and treated with the two methods. in 95 cases the agent was isolated from both, and ... | 1992 | 1340031 |
| [helicobacter pylori in barrett esophagus]. | the authors evaluated the prevalence of colonize by helicobacter pylori in 21 adults patients with barrett's esophagus; 12 males and 9 females; with ranges of age from 21 to 81 years and a medium of 56.4 years old. it was detected in 23.8% that helicobacter pylori was positive in barrett's esophagus, being quite higher, 26.6% in patients over 50 years old. in the five cases with positive helicobacter pylori, the barrett esophagus presented a fundic gastric mucosa and no one intestinal metaplasia ... | 1992 | 1340675 |
| [helicobacter pylori in patients with ulcerative dyspepsia]. | a group of consecutive patients with ulcer dyspepsia were studied by endoscopy, antral and duodenal biopsy; by histologic determination of helicobacter pylori (hp) and by silver staining (warthin starry technique). 68.31% were found to be infected. in those patients who showed chronic antritis (69.30% of the patients), hp was present in 92.85% of cases. in gastric and duodenal ulcer patients, similar rates were shown (76.47% and 76.92% respectively. in cases with normal histology findings hp was ... | 1992 | 1340676 |
| [duodenal ulcer: the current etiopathogenic concepts, acid hypersecretion? helicobacter pylori? nonsteroidal anti-inflammatory drugs?]. | 1992 | 1340682 | |
| [nonulcerative dyspepsia associated with helicobacter pylori]. | 30 patients with non ulcer dyspepsia (nud) were evaluated to find out if there was a relationship with helicobacter pylori (hp) infection. gastric biopsies from the antrum were taken and two of them sent to pathology to be stained with h&e and warthin-starry. the other three were sent to microbiology, for urease-test, culture and frotis with gram stain. to diagnose hp was necessary to get it at least in two of the performed test. this was possible in 20 (66.66%). chronic active gastritis was obs ... | 1992 | 1340809 |
| [gastroduodenitis and helicobacter pylori in uremic patients]. | we studied 26 patients (p) with end stage renal failure (rf) and 26 healthy volunteers (hv) to investigate the prevalence of helicobacter pylori (hp) and its relation with chronic gastritis (cg) and chronic duodenitis (cd). we analyzed 312 gastric and duodenal mucosal biopsies stained with h & e and giemsa. categorical data were assessed by the x2 and fisher's exact test. probability values of p < 0.05 were considered significant. endoscopic lesions correlated with histological gastritis and duo ... | 1992 | 1340811 |
| [the recurrence of duodenal ulcer after treatment for helicobacter pylori. a randomized, double-blind, placebo-controlled study]. | we studied 63 duodenal ulcer (du) patients (p) diagnosed by upper gastrointestinal endoscopy (uge) and helicobacter pylori positive (hp). patients were randomized, double-blinded to receive placebo (pg) 30p or amoxicillin plus metronidazole 33p (tg). all of them took famotidine for six weeks and at this point uge was performed. du healing was similar in both groups. hp eradication was possible in 14/24p of tg and 4/23 of pg (58.33% vs 17.39%) difference was statistically significant. du recurren ... | 1992 | 1340835 |
| pathophysiology and clinical relevance of helicobacter pylori. | considerable knowledge has recently accumulated on the mechanism by which helicobacter pylori (h. pylori) induces chronic gastritis. although h. pylori is not an invasive bacterium, soluble surface constituents can provoke pepsinogen release from gastric chief cells or trigger local inflammation in the underlying tissue. urease appears to be one of the prime chemoattractants for recruitment and activation of inflammatory cells. release of cytokines, such as tumor necrosis factor alpha, interleuk ... | 1992 | 1341068 |
| progress with proton pump inhibition. | the proton pump, a h+/k(+)-atpase located on the secretory canalicular membrane of the parietal cell, forms the final pathway for gastric acid secretion. omeprazole is concentrated in the secretory canaliculus, where it is converted to its active form, which binds covalently with the h+/k(+)-atpase, thus inhibiting acid secretion arising from any stimulus. meta-analysis has defined the primary determinants for peptic ulcer healing as the degree of acid suppression, the duration of suppression ov ... | 1992 | 1341069 |
| distinct patterns of chronic gastritis associated with carcinoid and cancer and their role in tumorigenesis. | a series of 60 gastric endocrine tumors comprised 44 body-fundus argyrophil carcinoids, of which 23 arose in a background of hypergastrinemia and type a chronic atrophic gastritis (a-cag), mainly with histologic patterns suggestive of an autoimmune process. only 22 percent (compared with 19 percent of 58 tumor-free a-cag cases) of 36 carcinoids and 21 percent of 19 a-cag carcinoids investigated had helicobacter pylori (hp) colonization, against 50 percent of 14 cag-associated neuroendocrine carc ... | 1992 | 1341079 |
| indirect immunofluorescence determination of the frequency of anti-h. pylori antibodies in brazilian blood donors. | 1. the accuracy of an indirect immunofluorescence (iif) test for the serodiagnosis of helicobacter pylori infection was evaluated in adult patients and compared with culture, preformed urease test and smears stained with carbolfuchsin. 2. we studied 80 consecutive patients submitted to gastroduodenoscopy (17 of whom were found to have duodenal ulcer) plus 57 patients with duodenal ulcer. 3. h. pylori was identified by microbiological methods in 65 of the 80 consecutive patients and in all 57 pat ... | 1992 | 1342599 |
| [pathogenesis of peptic ulcer: role of helicobacter pylori gastritis and its course during antibiotic and/or antisecretory treatment]. | a systematic investigation of the histologic pattern of antral and corpus gastritis has been carried out in 1177 patients with various clinical conditions. an increased rate and severity of antral mucosa gastritis activity as well as surface epithelium cytotoxic lesions and helicobacter pylori colonization, coupled with low rates and severity of the same parameters in corpus mucosa gastritis (usually of superficial nature so as to spare the integrity of acidopeptic glands) were the main features ... | 1992 | 1343564 |
| helicobacter pylori and gastroduodenal disease: pathogenesis and host-parasite interaction. | helicobacter pylori has been shown to be the cause of chronic active gastritis and the evidence that it is involved in the development of peptic ulcer disease and gastric cancer is compelling. narrow host range, tissue specificity, and chronic inflammation are hallmarks of infection. the study of virulence determinants has just begun but it seems likely that urease, adhesins, cytotoxins, and mediators of inflammation will prove to be important. | 1992 | 1344668 |
| [acute erosive gastritis and helicobacter pylori infection]. | 1992 | 1345353 | |
| eradicating helicobacter pylori. | 1992 | 1345965 | |
| eradicating helicobacter pylori. | 1992 | 1345966 | |
| eradicating helicobacter pylori. | 1992 | 1345967 | |
| eradicating helicobacter pylori. | 1992 | 1345968 | |
| impaired helicobacter pylori urease enzyme activity by histamine 2 receptor antagonist. | 1992 | 1346480 | |
| helicobacter pylori infection induces a decrease in immunoreactive-somatostatin concentrations of human stomach. | immunoreactive-somatostatin (ir-somatostatin) concentrations of the gastric mucosa and gastric juice with helicobacter pylori infection were measured in the human stomach. one hundred seventy-one patients (106 males, 65 females; mean age, 52.0; range, 19-84 years) were registered. gastric juice and mucosa were obtained with the usual endoscopy procedure. somatostatin concentration was measured by radioimmunoassay. the ir-somatostatin concentrations in the h. pylori-negative group were significan ... | 1992 | 1346517 |
| dna patterns of helicobacter pylori isolated from gastric antrum, body, and duodenum. | biopsy specimens for culture of helicobacter pylori were obtained from two different sites in the antrum, gastric body, and duodenal cap in 20 patients during endoscopic investigation of dyspepsia. h. pylori was identified in 64 isolates obtained from 15 of the 20 patients. analysis of chromosomal dna from these isolates of h. pylori showed that 13 of 15 patients harbored a single strain of h. pylori throughout their stomach and duodenum. two differing h. pylori types were found in two patients. ... | 1992 | 1347029 |
| helicobacter pylori infection and overcrowding in childhood. | 1992 | 1347120 | |
| bismuth subsalicylate in the treatment of h2 blocker resistant duodenal ulcers: role of helicobacter pylori. | fifty nine patients with helicobacter pylori positive duodenal ulcers that failed to heal after a six week course of treatment with h2 blockers were randomly assigned to one of the following three regimens: (i) bismuth subsalicylate, 600 mg three times daily (n = 19), (ii) ranitidine, 300 mg at night (n = 20), (iii) bismuth subsalicylate plus ranitidine (n = 20). cumulative ulcer healing rates after four and eight weeks respectively were as follows: bismuth subsalicylate 74% (14/19) and 95% (18/ ... | 1992 | 1347278 |
| [h2-receptor antagonist-refractory ulcer--its pathophysiology and role of proton-pump inhibitors]. | among h2-receptor antagonist (h2ra)-refractory ulcers, non-responders that did not heal after 5 months therapy had high intraluminal ph in the basal condition and high sensitivity to inhibition of acid secretion by h2ra but possessed gastric mucosa to generate less prostaglandins. combination therapy of pge1-analogue with h2ra healed these ulcers by 60%. proton-pump inhibitor (ppi) exerted a complete inhibition of acid secretion in these patients and the rate of healing was 88%. helicobacter pyl ... | 1992 | 1347325 |
| [proton pump inhibitors: their merits and demerits, and perspectives for future investigation]. | proton pump inhibitors have a potent antisecretory activity and are under development in many pharmaceutical companies. in this paper, the merits and demerits of the drugs, which have been revealed by experimental studies in humans and animals, are reviewed. issues of the drugs which remain to be examined in the future are also discussed in reletion to their application in peptic ulcer patients. the issues include 1) genotoxicity of the drugs with long-term treatment; 2) their possible contribut ... | 1992 | 1347330 |
| review article: maintenance treatment with h2-receptor antagonists for peptic ulcer disease. | in recent years a number of different strategies for managing patients with peptic ulcer disease have become available. the present review discusses the relative merits of each form of treatment. intermittent treatment (whether given in response to symptoms or as a prophylactic regimen prescribed seasonally or at weekends) fails to prevent ulcer recurrence and leaves patients at risk of haemorrhage and perforation. anti-helicobacter pylori therapy, although useful in certain circumstances, canno ... | 1992 | 1347467 |
| helicobacter pylori gastritis and gastric malt-lymphoma. | 1992 | 1347613 | |
| high incidence of primary gastric lymphoma in northeastern italy. | we previously noted an extraordinarily high number of cases of primary gastric lymphoma (pgl) in northeastern italy. we have now formally compared the incidence in feltre, italy, with that in three similar communities in the uk. each community has a stable population served by a single endoscopy unit and histopathology laboratory. there were 13 times more cases of pgl in feltre in 1986-91 than in the uk communities (66 vs 5 per 100,000 per 5 years). the incidence of gastric adenocarcinoma was al ... | 1992 | 1347858 |
| diagnostic value of decreasing igg, iga, and igm antibody titres after eradication of helicobacter pylori. | titres of antibody to helicobacter pylori are known to fall with eradication of bacteria. to find out what degree of fall would reliably indicate eradication, 144 patients with helicobacter pylori infection were given antimicrobial therapy for 2 weeks and then followed up at 6 weeks, 6 months, and 12 months with serological tests, bacterial cultures, and histological studies of gastric specimens. 6 weeks after treatment igg titres had fallen by 20-30% irrespective of the success of bacterial era ... | 1992 | 1348298 |
| childhood living conditions and helicobacter pylori seropositivity in adult life. | infection with helicobacter pylori increases an individual's risk of peptic ulceration and gastric cancer. in the developed world, prevalence of infection rises with age and varies with social class. we used a cross-sectional study design to test the hypothesis that h pylori infection would be more closely associated with childhood living conditions than with current socioeconomic status. prevalence of igg antibodies against h pylori was determined with an enzyme-linked immunosorbent assay in 21 ... | 1992 | 1348299 |
| urease-associated heat shock protein of helicobacter pylori. | helicobacter pylori urease is an extracellular, cell-bound enzyme with a molecular weight of approximately 600,000 (600k enzyme) comprising six 66k and six 31k subunits. a 62k protein is closely associated with the h. pylori urease, both in crude preparations and after gel filtration; this protein can be removed from the urease by ion-exchange chromatography without inactivating the enzyme. we purified this urease-associated protein and determined its n-terminal amino acid sequence. the sequence ... | 1992 | 1348725 |
| helicobacter pylori infection with age. | 1992 | 1349144 | |
| treatment of peptic ulcer disease: is helicobacter pylori a consideration? | 1992 | 1349551 | |
| short- and long-term management of peptic ulcer disease: current role of h2-antagonists. | with numerous active agents available to treat peptic ulcer disease both acutely and long-term, this paper reviews various aspects of these agents and their effect on the disease process, reviewing efficacy, compliance, incidence of relapse, side-effect profile, drug interactions and the effect on the natural history of peptic ulcer disease. helicobacter pylori is obviously a factor in the occurrence of peptic ulcer disease, but with the high prevalence of asymptomatic infection and evidence sug ... | 1992 | 1349553 |
| helicobacter pylori reinfection 4 years post-eradication. | 1992 | 1349686 | |
| h2 receptor antagonist or h. pylori eradication? | to assess the healing and relapse rate of duodenal ulcer (du) treated with h2 receptor antagonists in helicobacter pylori (hp) positive vs negative cases, we analysed 95 cases of endoscopically proven duodenal ulcer. h. pylori colonization was found in 73 (77%) patients before treatment. no difference was observed in the pre-treatment characteristics between patients with hp positive and hp negative duodenal ulcers. healing rates with h2 receptor antagonist at 8 weeks were 90% and 91% respective ... | 1992 | 1350800 |
| helicobacter pylori seropositivity in symptom-free children. | 1992 | 1351204 | |
| serological tests to monitor treatment of helicobacter pylori. | 1992 | 1351623 | |
| serological tests to monitor treatment of helicobacter pylori. | 1992 | 1351624 | |
| v workshop on gastroduodenal pathology and helicobacter pylori. dublin, ireland, july 5-7, 1992. abstracts. | 1992 | 1351889 | |
| helicobacter pylori, gastritis and duodenitis in the healing process of duodenal ulcer. | the occurrence of antral gastritis, duodenitis, gastric metaplasia and helicobacter pylori (h. pylori) were compared between 63 endoscopically proven duodenal ulcer (du) patients and 34 non-ulcer dyspepsia (nud) patients with no ulcer history and no ulcer present as documented by endoscopy. the du group showed a significantly higher rate of active antral gastritis (89% vs 41% p less than 0.05), a higher antral h. pylori carrying rate (76% vs 27% p less than 0.01), a higher rate of active chronic ... | 1992 | 1352340 |
| clarithromycin and omeprazole for helicobacter pylori. | 1992 | 1353155 | |
| helicobacter pylori infection in early infancy. | 1992 | 1354827 | |
| age-related increase of helicobacter pylori frequency in symptom-free and in dyspeptic children. | 1992 | 1355229 | |
| molecular typing of helicobacter pylori by chromosomal and plasmid dna organization. | diverse strains of helicobacter pylori were examined in order to initiate a molecular epidemiological typing scheme for this agent of human gastritis. twelve differently-sized plasmids from 1.8 to 63 kbp were identified in those strains harbouring extrachromosomal dna. recombinant dna probes were cloned randomly from the chromosome of the (plasmid-free) type strain (nctc 11637), and used to probe genomic southern blots for restriction site variation in and around homologous loci. genus-specific ... | 1992 | 1356227 |
| [effect of a long-term oral ammonia administration on immunoreactive-somatostatin concentrations of rat stomach]. | the effect of a long-term oral ammonia administration on immunoreactive-somatostatin concentrations was investigated in rat stomach. the gastric ir-somatostatin concentrations in the group treated with 0.01% ammonia (ph 9.6) for four weeks were significantly higher than those in both the group treated with 0.1% ammonia (ph 10.4), 0.1 mm-naoh (ph 9.6), or distilled water (ph 7.0) for four weeks and the group treated with 0.01% ammonia for two weeks. on the contrary, ir-somatostatin levels in the ... | 1992 | 1357215 |
| effect of helicobacter pylori on gastric somatostatin in duodenal ulcer disease. | infection of the gastric antrum by helicobacter pylori is associated with recurrent duodenal ulcer disease but the mechanism of ulcerogenesis is unclear. since pathways inhibiting gastric secretion are defective in patients with duodenal ulcers, we investigated whether h pylori interferes with the normal gastric inhibition that is mediated by somatostatin. we studied 28 patients with active duodenal ulcers in whom h pylori was eradicated successfully. in 18 patients, we measured the density of a ... | 1992 | 1357347 |
| helicobacter pylori seroprevalence in patients with rheumatoid arthritis: effect of nonsteroidal anti-inflammatory drugs and gold compounds. | to investigate the relationship between helicobacter pylori infection and nonsteroidal anti-inflammatory drug (nsaid) intolerance and the effect of gold use on the seroprevalence of h. pylori. | 1992 | 1357968 |
| structural comparison of urease and a groel analog from helicobacter pylori. | electron microscopy of purified protein preparations indicated that helicobacter pylori urease consisted of circular particles that are 13 nm in diameter, some of which showed indications of threefold rotational symmetry. a groel analog of h. pylori (hp60k) appeared as a disc-shaped molecule with a diameter similar to that of urease but possessed sevenfold rotational symmetry. in a side-view projection, hp60k appeared as two or four discs stacked side by side. | 1992 | 1358875 |
| serological assessment of helicobacter pylori eradication. | 1992 | 1359233 | |
| isolation of helicobacter pylori from human faeces. | helicobacter pylori is arguably the commonest chronic infection in man. however, its route of transmission is unknown. we have isolated viable h pylori from the faeces of an infected individual from the gambia. the organism was cultured on selective media after concentration of faecal bacteria by centrifugation in a buffer equilibrated with a microaerophilic gas mixture. growth characteristics, microscopic appearances, and enzyme activities were the same as those of a typical gastric isolate of ... | 1992 | 1359263 |
| [drug therapy of peptic ulcer in the elderly]. | medical therapy of peptic ulcers in elderly patients should depend on drugs which have to be administered only once daily. in addition, the ideal compound should have minimal side effects as well as minimal, if any, interactions with concomitant forms of therapy. from this point of view, acid-inhibitory drugs are preferable to other anti-ulcer drugs, the latter having little importance in advanced age. for ulcer healing, the proton pump inhibitor omeprazole is recommended, whereas h2-blockers (p ... | 1992 | 1359717 |
| studies on antiulcer drugs. vi. 4-furyl-2-guanidinothiazoles and related compounds as potent histamine h2-receptor antagonists. | a series of 4-furyl-2-guanidinothiazole derivatives and related compounds were synthesized and evaluated for histamine h2-receptor antagonist and gastric acid antisecretory activities. among them, compounds i-17, i-48 and i-49 showed high activities in these tests. in addition, compound i-17 possessed potent inhibitory activities on each of the gastric ulcers induced by stress, ethanol and hcl-aspirin. on the other hand, compound i-48 demonstrated antimicrobial activity against helicobacter pylo ... | 1992 | 1359931 |
| helicobacter pylori and peptic ulcers in rheumatoid arthritis patients receiving gold, sulfasalazine, and nonsteroidal anti-inflammatory drugs. | the conflicting reports on gold and helicobacter pylori could be related to the use of serological tests of unproven value in nsaid patients, and to the lack of the appropriate control groups. more important is the fact that the endoscopic consequences of the possible effect of gold on h. pylori have not been investigated. we therefore decided to assess the prevalence of h. pylori and peptic ulcers in rheumatoid patients being treated with gold sodium thiomalate (gst) plus nsaid, sulfasalazine p ... | 1992 | 1360191 |
| pcr-based rflp analysis of dna sequence diversity in the gastric pathogen helicobacter pylori. | dna sequence diversity among 60 independent isolates of the gastric pathogen helicobacter pylori was assessed by testing for restriction fragment length polymorphisms (rflps) in several pcr-amplified gene segments. 18 mbol and 27 haeiii rflps were found in the 2.4 kb urea-ureb (urease) segment from the 60 strains; this identified 44 separate groups, with each group containing one to four isolates. with one exception, each isolate not distinguished from the others by rflps in urea-ureb was distin ... | 1992 | 1361982 |
| bacterial flagellar diversity and significance in pathogenesis. | bacterial flagella are structurally diverse, ranging from the thoroughly investigated model examples found in escherichia coli and salmonella typhimurium to the more exotic sheathed flagella of, for example, helicobacter pylori, and the complex multi-flagellin endoflagella found in many spirochaetes. we summarize some of the emerging structural and genetic findings relating to these more novel flagellar types, and outline their possible significance in the pathogenicity of some medically importa ... | 1992 | 1362173 |
| [current alteration of helicobacter pylori in gastro-duodenal diseases]. | the current alteration of the detection rate of helicobacter pylori (h. pylori) on mucous membranes of the stomach has been surveyed and reviewed for 49 cases of gastro-duodenal diseases. the survey has been conducted for 3 years and an endoscopic examinations have been performed 2-8 times. on the first visit, the diagnosis can be made endoscopically, and h2 blockers and another agents were used as therapeutic drugs. the detection rate was 67.3% (33 cases) for positive cases and positive reactio ... | 1992 | 1363434 |
| resistance to medical ulcer therapy--possible reasons and management. | in 112 patients with duodenal ulcer (males, mean age 29, range 18-35) with a history of at least 3 years, and never being treated with h2-antagonists, maintenance therapy with tagamet was started. all of them had ulcer recurrence when entering the study. the first two months a full dose was applied, after this bedtime doses up to 24 months. endoscopy was performed at the beginning, after the first and second months and then every two-month period. gastric secretion was measured every 2-3 months. ... | 1992 | 1364278 |
| helicobacter pylori before and after gastric reduction for morbid obesity. | nine patients with morbid obesity were evaluated for the presence of helicobacter pylon (hp) before gastric reduction, and all were negative. fifteen patients, including those nine, were evaluated for the presence of hp in antral and 'channel' region biopsies by culture and urease test after gastric reduction. hp-negative patients totaled 73.3% by both tests, although chronic superficial gastritis type 'b' was found in eight out of 13 (61.5%), and six out of seven (85.7%) gastritis patients were ... | 1992 | 10765199 |
| [brief history of laboratory technique on the examination of helicobacter pylori] (chi). | 1992 | 11612990 | |
| association of helicobacter pylori and nonulcer dyspepsia. | 1993 | 17587980 | |
| reply: association of helicobacter pylori and nonulcer dyspepsia. | 1993 | 17587983 | |
| helicobacter pylori associated dyspepsia in 208 patients from southern saudi arabia. | the frequency of helicobacter pylori (hp) infection in 208 patients with upper gastrointestinal tract symptoms from the southern province of saudi arabia was studied prospectively. the occurrence of hp was documented histologically and using a rapid urease test in antral endoscopic biopsies. our results showed that 82.2% of the 208 patients included were positive for hp with a male:female ratio of approximately 1:1 (88:83). the age range was 14 to 80 years and the median age was 38.2 years. the ... | 1993 | 17590697 |
| activity of cefixime against helicobacter pylori. | the in vitro activities of cefixime, a new third-generation cephalosporin, and of 18 other antimicrobial agents against 18 strains of helicobacter pylori were determined. the strains of h. pylori were isolated from gastric biopsy specimens and tested for sensitivity to antibiotics by an agar dilution technique under microaerophilic conditions. among cephalosporins, cefixime had the highest antibacterial activity, with a mic for 90% of strains (mic(90)) of 0.125 mg/l. josamycin and erythromycin, ... | 1993 | 18611550 |
| can eradication of helicobacter pylori prevent gastric cancer? | 1993 | 28474315 | |
| omeprazole: a pharmacoeconomic evaluation of its use in duodenal ulcer and reflux oesophagitis. | omeprazole regulates gastric acid secretion and is an effective treatment of acute duodenal ulcer and reflux oesophagitis, achieving more rapid healing and symptomatic relief than histamine h 2-receptor antagonists. when administered as maintenance therapy, omeprazole reduces the incidence of relapse. the drug is also highly effective in patients poorly responsive to histamine h 2-receptor antagonists. the daily acquisition cost of omeprazole is higher than that of histamine h 2-receptor anta ... | 1993 | 10146883 |
| [the pathogenic role of helicobacter pylori]. | the urease test and bacterioscopy of impression smears were used to detect helicobacter pylori (hp) in biopsies from pyloric gastric mucosa of 77 (89.5%) of 86 chronic gastritis patients, of 27 (4%) from 32 duodenal ulcer patients, of 84 (84.0%) from 100 healthy male subjects aged 18-20. there was focal hyperemia in pyloric part of the stomach in 59 patients, leukocytic infiltration of mucous membrane was found histologically in 78 ones. close correlation between complaints, endoscopic and histo ... | 1993 | 9132998 |
| [the factors determining the course and outcome of chronic duodenitis in adolescents and young people]. | causes involved in progression of duodenal lesions have been analyzed in 55 adolescents with chronic duodenitis. five-year follow-up revealed factors with potential influence on the outcome: sex, acid-peptic factor, mucosal contamination with helicobacter pylori, an initial morphological form of duodenitis. the latter developed into peptic ulcer in 15% of the male patients. progression of duodenitis was associated with emergence of chronic gastritis. motor biliary function deteriorated in 39% of ... | 1993 | 9133005 |
| inhibition of gastric mucosal mucin receptor by helicobacter pylori lipopolysaccharide. | a gastric mucosal mucin receptor has been isolated from the epithelial cell membrane by affinity chromatography on wheat germ agglutinin. the receptor protein displayed an apparent molecular weight of 97kda and exhibited binding specific to gastric mucin in a concentration-dependent manner. the binding of mucin to the mucosal receptor was inhibited by lipopolysaccharide from h. pylori. the inhibitory effect was proportional to the concentration of lipopolysaccharide up to 30 micrograms/ml, at wh ... | 1993 | 7514919 |
| immunological specificity of helicobacter pylori urease and identification by immunological detection of its specific urease. | helicobacter pylori urease was recovered as a single peak by deae-sepharose column chromatography and sephacryl s-200 gel filtration. the purified urease was obtained by fast protein liquid chromatography using a mono q column. the purified urease preparation gave a single band in polyacrylamide gel disc electrophoresis. latex particles were sensitized with anti-urease immunoglobulin. the sensitized latex particles were agglutinated with the purified urease and by cell sonicates obtained from 55 ... | 1993 | 7505793 |
| isolation of a sialic acid-specific surface haemagglutinin of helicobacter pylori strain nctc 11637. | a deionized water extract of helicobacter pylori nctc 11637 contained haemagglutinin activity that was (i) soluble (i.e., not associated with particulate material sedimented by centrifugation at 100,000 x g for 1 h), (ii) stable to lyophilization, (iii) heat-labile, (iv) chymotrypsin-sensitive, (v) inhibited by fetuin, orosomucoid, and nanlac, but not by asialofetuin and (vi) inactive against guinea pig erythrocytes incubated with clostridium perfringens neuraminidase, but active against untreat ... | 1993 | 7506596 |
| [digestion of human gastric mucous by extracellular helicobacter pylori enzyme]. | helicobacter pylori (hp) is a causative pathogen of chronic gastritis and strongly associated with recurrence of duodenal ulcers, but the mechanism is not known. we studied the possible digestion of gastric mucus by hp extracellular enzyme in human stomach. hp was isolated from biopsy specimens taken from peptic ulcer patients or normal individuals and its extracellular enzyme was collected. incubation of human gastric mucosa with hp extracellular enzyme resulted in a significant decrease of pas ... | 1993 | 7506799 |
| helicobacter pylori: a comparison of clo test and giemsa's stain with culture in dyspeptic patients. | the prevalence of h.pylori in thailand is high compared with western countries and is the same as in china. we suggest either rapid urease test (clo test) or giemsa stain to be a rapid, reliable and convenient detection method for h.pylori and is also suitable for use in follow-up studies by gastroenterologists. | 1993 | 7509357 |
| [comparative evaluation of some morphologic methods for detecting helicobacter pylori in gastric mucosa]. | gastroscopic examination was performed in 183 patients with upper gastrointestinal symptoms, with brush biopsy and taking of mucosa specimens for cytological and histopathological examination in order to detect the presence of helicobacter pylori. greater effectiveness of brush biopsy was demonstrated in comparison to histological examination of tissue fragments and significantly higher effectiveness of staining using the giemsa-may-grunwald method was shown in comparison to staining with hemato ... | 1993 | 7526557 |
| cloning, nucleotide sequence, and expression of a gene encoding an adhesin subunit protein of helicobacter pylori. | gene hpaa, which codes for the receptor-binding subunit of the n-acetylneuraminyllactose-binding fibrillar hemagglutinin (nlbh) of helicobacter pylori, was cloned and sequenced. the protein expressed by hpaa, designated hpaa, was identified as the adhesin subunit on the basis of its fetuin-binding activity and its reactivity with a polyclonal, monospecific rabbit serum prepared against nlbh purified from h. pylori. sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis and western bl ... | 1993 | 7678592 |
| serum 13c-bicarbonate in the assessment of gastric helicobacter pylori urease activity. | noninvasive detection of helicobacter pylori (hp) requires serum or salivary antibody testing or the co2 breath test. since gastric hp produces a potent urease, a meal rich in 13c-labeled urea should lead to a measurable quantity of isotopic co2 in the serum. this study investigates the feasibility, sensitivity, specificity, and potential of the measurement of serum 13c-bicarbonate (13chco3) in determining the presence of gastric hp. nineteen patients with upper gastrointestinal symptoms assesse ... | 1993 | 7679876 |
| structural analysis and demonstration of the 29 kda antigen of pathogenic entamoeba histolytica as the major accessible free thiol-containing surface protein. | the 29 kda protein of pathogenic entamoeba histolytica is a cysteine-rich surface antigen which we recently characterized by cdna sequencing and by using monoclonal antibodies which differentiated between pathogenic and non-pathogenic clinical isolates. to determine the structure and biochemical attributes of this protein, a repertoire of immunological techniques using monoclonal antibodies, and radiolabelling were employed. we demonstrated that the 29 kda protein forms a 60 kda dimer and a high ... | 1993 | 7682280 |
| affinity of the gastric pathogen helicobacter pylori for the n-sulphated glycosaminoglycan heparan sulphate. | binding of 125i-heparan sulphate was a common property of helicobacter pylori strains isolated from patients with gastroduodenal ulcer diseases. binding was (i) saturable; (ii) reversible by the addition of unlabelled heparan sulphate and heparin; (iii) inhibited by unlabelled heparan sulphate, heparin, and heparin oligosaccharides but not by other glycosaminoglycans of comparable size (chondroitin sulphate and dermatan sulphate) or by highly glycosylated glycoproteins (hog gastric mucin and fet ... | 1993 | 7682621 |
| helicobacter pylori detection: a quality and cost analysis. | histopathologic interpretation of hematoxylin and eosin (h&e)-stained endoscopic biopsies is a common method for identifying helicobacter pylori. few studies report the accuracy of this method, and none have compared costs of other diagnostic methods. in the clinical setting of a community hospital using standard diagnostic techniques, the purpose of this study were to determine 1) the comparative sensitivities and specificities of the h&e stain, the warthin-starry silver stain, the giemsa stain ... | 1993 | 7683175 |
| helicobacter pylori potentiates histamine release from serosal rat mast cells in vitro. | helicobacter pylori seems to be involved in the etiology of peptic ulcer and chronic gastritis. histamine is fundamental in gastric secretion modulation, and some features of h. pylori-associated gastritis (edema, vasodilatation, inflammatory cell infiltration) are typical of the histamine-mediated response. this in vitro study has been undertaken as a preliminary step, in order to find a possible link between h. pylori and histamine release. h. pylori isolated from gastric biopsies has been tes ... | 1993 | 7683264 |
| partial characterization of an external polysaccharide of helicobacter pylori by using an immunoglobulin m monoclonal antibody. | a monoclonal immunoglobulin m antibody, hp15/36, was produced by a hybridoma cell line prepared by fusion of mouse myeloma cell line sp2/o with spleen cells of mice immunized with helicobacter pylori d273 (french strain). immunoelectron microscopy of whole bacteria and ultrathin sections showed that the determinant was located outside the bacterial cell, possibly in the outermost areas. this external reactivity was observed by immunofluorescence and immunoperoxidase assays and was confirmed by i ... | 1993 | 7684730 |
| helicobacter pylori in gastric biopsies--should you trust the pathology report? | the presence of helicobacter pylori in gastric biopsies is closely associated with gastritis and duodenal ulceration. we have assessed the reliability of h pylori identification on haematoxylin and eosin (h & e) stained sections of gastric biopsies showing gastritis. a set of 20 slides was shown to 20 histopathologists (a total of 400 diagnoses); 11 of them were h pylori-positive, assessed using two special stains. participants were asked to comment on the presence or absence of h pylori on h & ... | 1993 | 7684784 |
| characteristics of helicobacter pylori alcohol dehydrogenase. | helicobacter pylori shows alcohol dehydrogenase activity, which in the presence of ethanol leads to in vitro production of acetaldehyde, a toxic and highly reactive substance. the present study was undertaken to further define h. pylori-related ethanol and acetaldehyde metabolism by characterizing h. pylori alcohol dehydrogenase and by determining whether the organism possesses aldehyde dehydrogenase. | 1993 | 7687573 |