Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [evaluation of two commercial kits for detection of helicobacter pylori specific antibodies in patients undergoing gastroscopy. a seroprevalence study in an asymptomatic population]. | we evaluate two different commercially available kits for detecting specific antibodies against helicobacter pylori in a group of 48 patients with gastrointestinal symptoms that underwent an endoscopic procedure. we also study the seroprevalence of anti-h. pylori antibodies in asimptomatic individuals from our area. | 1992 | 1606220 |
| is helicobacter pylori the cause of dyspepsia? | to determine the association between infection with helicobacter pylori and dyspepsia. | 1992 | 1606428 |
| [short-term therapy with high dosage omeprazole and amoxicillin for helicobacter pylori eradication. a pilot study]. | in an open study, 50 patients with helicobacter pylori-associated ulcer disease or severe functional dyspepsia were treated over one week with 2 x 40 mg omeprazole in the morning and evening preprandially and 4 x 500 mg amoxicillin suspension one hour before meals and at night. fourty-seven patients (ulcer disease: n = 40, functional dyspepsia: n = 7) completed the study without contravening the protocol. the proportion of helicobacter pylori eradication four weeks after cessation of study medic ... | 1992 | 1579087 |
| [polymorphism in helicobacter pylori--a key function in recurrence of infection?]. | despite the fact that helicobacter (h.) pylori is ubiquitous throughout the world, little is known at present about the source of infection and mode of transmission. person-to-person transmission may be of importance. the fact that helicobacter pylori can revert to a coccoid form stimulated speculation about its role in transmission and as a possible cause of reinfection in duodenal ulcer disease. various antibacterial agents (bismuth subcitrate 32 mg/l bismuth subsalicylate 64 mg/l, amoxicillin ... | 1992 | 1579096 |
| [studying the role of helicobacter pylori infection in recurrent abdominal pain in children]. | the authors studied the role of helicobacter pylori at recurrent abdominal pain in childhood. helicobacter pylori infection hasn't been found at the 42 examined children. the endoscopy showed esophagitis in 34 cases. the quick urease test, the histological examination, and the bacterial culture are proposed to carry out in ulcus duodeni, gastritis typ. b ulcus ventriculi and not necessary to carry out if the endoscopy shows only esophagitis--emphasize the authors. | 1992 | 1608607 |
| helicobacter pylori and gastroduodenal disease. | helicobacter pylori infection is now recognized as the primary cause of active chronic gastritis in humans. most infected persons remain asymptomatic, but are at increased risk for the development of peptic ulcer disease and possibly gastric cancer. the pathogenesis of this infection is not well understood, but motility and urease activity are virulence factors in an animal model. the eradication of h. pylori infection is associated with resolution of gastritis and a decreased rate of duodenal u ... | 1992 | 1580578 |
| helicobacter pylori and peptic ulcer disease in sri lanka. | the variation in the healing and the relapse rates of peptic ulcer disease has led to the search for other factors in the pathogensis of peptic ulcer disease. helicobacter pylori is believed to be responsible for these different patterns of healing. the results of a study to detect helicobacter pylori in sri lankan patients having duodenal ulcer, gastric ulcer, gastritis and non-ulcer dyspepsia are presented in this paper. the method employed was the urease test which detects the urease enzyme o ... | 1992 | 1581990 |
| helicobacter pylori: the african enigma. | 1992 | 1582581 | |
| influence of age and helicobacter pylori infection on serum pepsinogens in healthy blood transfusion donors. | in a healthy population pepsinogen a and pepsinogen c increase with advancing age. as pepsinogen a and c are raised in chronic superficial gastritis which is caused by h pylori infection, we investigated whether h pylori is responsible for the age related increase of pepsinogen a and c. in h pylori positive blood transfusion donors serum pepsinogen a (mean (sd) 73 (35) micrograms/ml v 52 (19) micrograms/ml, p much less than 0.01) and c (mean (sd) 24 (13) micrograms/ml v 10 (7) micrograms/ml, p m ... | 1992 | 1582585 |
| triple therapy against helicobacter pylori. | 1992 | 1586557 | |
| [serological screening for helicobacter pylori. can a blood test make gastroscopy superfluous?]. | 1992 | 1587222 | |
| helicobacter pylori and non-ulcer dyspepsia. | 1992 | 1612344 | |
| mechanism of gastric mucosal damage induced by ammonia. | the mechanism for helicobacter pylori-induced gastric mucosal injury remains obscure. h. pylori has high urease activity to produce ammonia from urea in the stomach. in this study, the effects of ammonia on (a) gastric mucosal integrity, (b) gastric mucosal hemodynamics, (c) mucosal cellular viability, (d) mitochondrial respiration, and (e) energy metabolism of gastric mucosal were investigated. ammonia (ph 10.3) at concentrations of greater than 125 mmol/l caused acute macroscopic gastric mucos ... | 1992 | 1587407 |
| helicobacter pylori infection: comparison among four different therapeutic regimens. | helicobacter pylori is both virulent and pathogenic, yet it is not clear what is the best way to treat the infection. this study compares the ability of 4 regimens of colloidal bismuth subcitrate (cbs) 120 mg q.i.d. for 4 weeks, combined with one or two antibiotics, to eradicate helicobacter pylori and assesses the outcome of eradication on antral gastritis and on symptoms of non-ulcer dyspepsia in 140 consecutive subjects (44 duodenal ulcers and 96 non ulcer dyspepsia). endoscopy with antral bi ... | 1992 | 1589252 |
| suppression of helicobacter pylori reduces gastrin releasing peptide stimulated gastrin release in duodenal ulcer patients. | helicobacter pylori increases gastrin release in duodenal ulcer patients. this may be through disruption or changes in the mucus layer affecting the access of luminal stimulants to gastrin releasing cells. the effect of suppressing h pylori on gastrin release stimulated by a non-luminal stimulus, gastrin releasing peptide (grp), was examined. eleven patients with active duodenal ulcer disease and colonised with h pylori received an intravenous infusion of grp (2.9 pmol/kg/minute for 30 minutes) ... | 1992 | 1612474 |
| helicobacter pylori eradication with doxycycline-metronidazole-bismuth subcitrate triple therapy. | triple therapy containing tetracycline hcl is currently among the most efficient combination therapies for eradication of helicobacter pylori. substitution of doxycycline for tetracycline hcl offers advantages of less frequent dosing and extrarenal excretion. in this study patients with duodenal ulcer or non-ulcer dyspepsia positive for h. pylori were randomized to either doxycycline or tetracycline hcl triple therapy in conjunction with bismuth subcitrate and metronidazole. of the 34 patients t ... | 1992 | 1589705 |
| purification of recombinant helicobacter pylori urease apoenzyme encoded by urea and ureb. | helicobacter pylori, a gram-negative, microaerophilic, spiral-shaped bacterium, is an etiologic agent of human gastritis and peptic ulceration and is highly restricted to the gastric mucosa of humans. urease, synthesized at up to 6% of the soluble cell protein, hydrolyzes urea, thereby releasing ammonia, which may neutralize acid, allowing survival of the bacterium and initial colonization of the gastric mucosa. the urease protein is encoded by two subunit genes, urea and ureb; however, accessor ... | 1992 | 1612735 |
| oxyntic and antral gastritis in the people's republic of china: diagnosis and relationship to helicobacter pylori. | this study investigates the relationship between gastritis and helicobacter pylori infection in the chinese population. particular focus was placed upon the grading of gastritis, using the recently developed "sydney system." five diagnostic procedures were used to establish h. pylori status, all of which were found to be highly sensitive and specific. histological chronic gastritis was reported in 93/108 (86.1%) of the patients examined, h. pylori infection being present in 73/93 (78.5%), and in ... | 1992 | 1590312 |
| helicobacter pylori lipopolysaccharide effect on the synthesis and secretion of gastric sulfomucin. | the effect of h. pylori lipopolysaccharide on the synthesis and secretion of sulfated mucin in gastric mucosa was investigated using mucosal segments incubated in the presence of [3h]proline, [3h]glucosamine and [35s]na2so4. the lipopolysaccharide, while showing no discernible effect on the apomucin synthesis was found to inhibit the process of mucin glycosylation and sulfation, which at 100 micrograms/ml lipopolysaccharide reached the optimal inhibition of 65%. the analysis of mucin secretory r ... | 1992 | 1590801 |
| electron microscopic evidence of treponema pallidum and helicobacter pylori in gastric tissue. | 1992 | 1595613 | |
| stability of ph gradients in vivo across the stomach in helicobacter pylori gastritis, dyspepsia, and health. | a layer of water-insoluble mucus gel is secreted by the gastric epithelium, and is believed to form an important barrier to acid injury. it is postulated that helicobacter pylori can alter ph gradients by damaging the mucus layer, but no data on ph gradients in vivo in patients with h. pylori gastritis have been published. we aimed to construct a map of mucus-bicarbonate layer ph gradients in health and disease. fourteen healthy asymptomatic volunteers (mean age, 46 yr) and 14 symptomatic patien ... | 1992 | 1595645 |
| [development of genetic and molecular approaches for the diagnosis and the study of the pathogenic power of helicobacter pylori, agent of inflammatory gastric diseases]. | helicobacter pylori (h. pylori) is a small gram negative bacillus, recently discovered, found in the stomach of patients with active chronic gastritis and duodenal ulcers. production of a potent urease has been described as a trait common to all h. pylori so far isolated. to clarify the role of urease in the pathogenic process, as well as to engineer genetic tools useful for the diagnosis of h. pylori, we cloned the genes responsible for urease activity. a genomic library was constructed in esch ... | 1992 | 1622109 |
| effect of sucralfate on the degradation of human gastric mucus by helicobacter pylori protease and lipases. | among the factors implicated in the weakening of mucus perimeter of gastric mucosal defense is helicobacter pylori, the pathogenic action of which appears to be exerted through the elaborated protease and lipase enzymes. we present evidence that the activities of these enzymes are inhibited by an antiulcer agent, sucralfate. the grown colonies of bacteria were washed with saline, filtered through sterilization filter, and the filtrate used as the enzyme source. in the absence of sucralfate, the ... | 1992 | 1595646 |
| optimal survival of helicobacter pylori under various transport conditions. | the ability of clinical isolates and type strains of helicobacter pylori to survive in stuart transport medium, isotonic saline solution, and urea-containing isotonic saline was evaluated. the influences of temperature (4, 10, 15, 20, and 30 degrees c) and holding time (6 to 48 h) and the effect of exposure to air on survival were also studied. the recovery rate of h. pylori was highest from stuart transport medium in comparison with the recoveries from the other transport media tested. we found ... | 1992 | 1624562 |
| evaluation of the performance of commercial test kits for detection of helicobacter pylori antibodies in serum. | we have compared the sensitivities, specificities, and predictive values of three commercial serological assays for the diagnosis of helicobacter pylori infection. a qualitative latex method (pyloriset; orion diagnostics), a semiquantitative enzyme-linked immunosorbent assay (elisa) (gap test igg; bio-rad), and a quantiative elisa (helico-g; porton cambridge) were used in 109 untreated dyspeptic patients. the presence of h. pylori was established when the results of culture and/or histology of t ... | 1992 | 1624571 |
| expression of hla-dr antigen in different histological types of gastric polyp. | to study the expression of hla-dr antigen in the different histological types of gastric polyps. | 1992 | 1624598 |
| [helicobacter pylori spectrum: from gastritis to malignancy]. | 1992 | 1625512 | |
| long-term omeprazole monotherapy is ineffective against helicobacter pylori infection. | 1992 | 1595667 | |
| immunoglobulin g antibodies to helicobacter pylori in patients with dyspeptic symptoms investigated by the western immunoblot technique. | helicobacter pylori is a gram-negative, curved, rod-shaped bacterium known to cause gastritis and to be an important factor in the pathogenesis of peptic ulcers. serological testing has recently been proposed as an aid in diagnosis of h. pylori infections. in this study, we used the western immunoblot technique to evaluate the possibility of using one or more of the antigens from h. pylori for this purpose. thirteen major bands and about 30 minor bands could be identified by western blotting whe ... | 1992 | 1629330 |
| helicobacter pylori lipopolysaccharide stimulates gastric mucosal pepsinogen secretion. | the effect of helicobacter pylori lipopolysaccharide on guinea pig gastric mucosal pepsinogen secretion has been examined using an ussing chamber technique. luminal addition of h. pylori lipopolysaccharide resulted in a fifty-fold stimulation of pepsinogen secretion compared to a twelve-fold increase with e. coli lipopolysaccharide. electron microscopy showed marked degranulation of zymogen granules but no evidence of chief cell disruption. | 1992 | 1600038 |
| cytopathic effects of helicobacter pylori on cultured mammalian cells. | cytopathic effects of broth-culture filtrates from eight clinical isolates and one reference strain of helicobacter pylori on three cultured mammalian cell lines were investigated. all the strains, including nctc 11637, produced cytotoxic factors that caused intracellular vacuolation on these cell lines. ags and sflep cells were more sensitive than hep-2 cells. to examine the role of urease in the cytotoxic effect, a urease-negative mutant was produced. filtrates from both wild-type and mutant s ... | 1992 | 1629896 |
| motility as a factor in the colonisation of gnotobiotic piglets by helicobacter pylori. | non-motile variants of helicobacter pylori (strain 26695) occurred with a frequency of 1.6 (sd 0.4) x 10(-4) variants/cell/division cycle, and reversion to the motile form occurred with a frequency of less than 10(-7) variants/cell/division cycle. the two forms remained greater than 90% pure for up to 50 cell divisions and differed only in the presence or absence of motility and flagella. bacteria were recovered from nine of 10 gnotobiotic piglets inoculated orally with motile h. pylori, but fro ... | 1992 | 1629897 |
| sucralfate diminishes basal acid output without affecting gastrin, h. pylori or gastritis in duodenal ulcer patients. | twelve patients with active duodenal ulcer disease and helicobacter pylori infection were treated with 1 g sucralfate q.d.s. for 1 month. ulcers healed in 8 of the 12 patients without an alteration in the h. pylori-associated antral gastritis. sucralfate produced a significant fall in basal acid output in all the patients, from a median of 4.8 (range 2.1-12.1) to 1.6 (0.4-8) mmol/h, p less than 0.01, whereas peak acid output was unchanged from 41 (21-59) before to 38 (24-55) mmol/h after treatme ... | 1992 | 1600044 |
| [stomach ulcer and helicobacter pylori]. | 1992 | 1632003 | |
| [helicobacter pylori]. | helicobacter pylori (hp) are gram-negative spiral bacteria which occur in the human stomach. the bacteria were cultured in vitro for the first time in 1983. it is suspected that the bacteria may cause chronic gastritis of type b and may also be a contributory cause of chronic ulceration and cancer of the stomach. the bacteria are accompanied by characteristic inflammatory changes in the gastric mucosa. the significance for gastritis, chronic ulceration, non-ulcer dyspepsia and carcinoma of the s ... | 1992 | 1632004 |
| review article: the treatment of helicobacter pylori infection. | the discovery of helicobacter pylori has stimulated great interest in its role in gastritis, non-ulcer dyspepsia and peptic ulceration. treatment regimens to eradicate this organism from gastric mucosa have also received considerable attention. current recommendations limit the use of triple drug combinations only to specific patient groups. | 1992 | 1600047 |
| [clinical significance of serological markers of helicobacter pylori]. | helicobacter pylori (h. pylori) is a gram-negative, curved bacillus known since 1983. it is supposed to play role in the pathogenesis of certain gastroduodenic diseases, e.g. non-ulcer dyspepsia (nud), chronic inflammation, ulcers, etc. serum samples of 70 patients who were examined for stomach complaints with gastroscopy and those of 22 healthy persons were analysed. the purpose of the study was to evaluate anti-h. pylori igg, igm and iga antibodies using elisa method. whether the antibodies ca ... | 1992 | 1635774 |
| does a previous course of tripotassium dicitrato bismuthate affect the subsequent chances of successful helicobacter pylori eradication? | we have performed a retrospective study of 103 patients with either peptic ulcer or non-ulcer dyspepsia, infected with metronidazole-sensitive strains of helicobacter pylori (h. pylori), who were treated with a combination of tripotassium dicitrato bismuthate and metronidazole for a period of at least two weeks. dual therapy with tripotassium dicitrato bismuthate plus metronidazole showed similarly high eradication rates (greater than or equal to 80%) of h. pylori from patients irrespective of a ... | 1992 | 1600049 |
| eicosanoid synthesis and helicobacter pylori associated gastritis: increase in leukotriene c4 generation associated with h. pylori colonization. | the importance of pro-inflammatory leukotriene c4 in helicobacter pylori (h. pylori) associated gastritis in man is unknown. fresh gastric biopsy specimens from 28 dyspeptic patients were obtained: 10 showed normal antral histology with no evidence of h. pylori, the remaining 18 patients exhibited histological gastritis and were h. pylori positive as assessed by histology, culture and urease test. twelve of these 18 patients received 240 mg twice daily colloidal bismuth subcitrate for four weeks ... | 1992 | 1641505 |
| short report: twenty-four-hour hyperpepsinogenaemia in helicobacter pylori-positive subjects is abolished by eradication of the infection. | twenty-four-hour plasma pepsinogen i and ii concentrations were determined in 8 healthy subjects with antibody to helicobacter pylori, before and after treatment with tripotassium dicitrato bismuthate, amoxycillin and metronidazole, therapy was successful in the 5 subjects with active h. pylori infection. in these subjects, median integrated 24-h plasma pepsinogen i and ii concentrations significantly decreased from 2288 and 357 micrograms.h/l before treatment, respectively, to 1811 and 171 micr ... | 1992 | 1600055 |
| detection of helicobacter pylori-like organisms in the stomach of some food-source animals using a monoclonal antibody. | to investigate a possible animal reservoir of helicobacter pylori, 15 pigs, 15 rabbits and 5 cows slaughtered for consumption were studied. raised serum igg levels were found in 93% of the pigs and 87% of the rabbits, but levels were normal in the cattle. in the controlled testings three of 22 humans had elevated igg to h pylori and in all three h pylori was detected by the use of monoclonal antibody. helicobacter pylori were identified in gastric brushings by a monoclonal antibody in 8 out of 1 ... | 1992 | 1600192 |
| helicobacter pylori and non-ulcer dyspepsia in zambia. | 1992 | 1604727 | |
| symptoms, gastritis, and helicobacter pylori in patients referred for endoscopy. | acute helicobacter pylori infection is associated with dyspeptic symptoms but chronic infection has not clearly been shown to cause symptoms. to define further the role of h. pylori infection and gastritis in dyspepsia, we interviewed all patients about to undergo upper endoscopy, recorded the primary indication for endoscopy, noted the endoscopic findings, and obtained antral biopsies. among non-ulcer patients there was a strong correlation of acute gastritis with h. pylori. gastritis and h. py ... | 1992 | 1607089 |
| helicobacter pylori infection in children. a clinical overview. | 1992 | 1643767 | |
| epidemiology of helicobacter pylori in southern china: identification of early childhood as the critical period for acquisition. | a large cross-sectional study to investigate the prevalence and possible modes of transmission of helicobacter pylori was done in southern china. serum samples (1727) were collected from guangzhou city and three rural areas of guangdong province, and the prevalence of h. pylori infection was determined using an elisa. each subject completed a questionnaire. the overall prevalence of h. pylori infection was 44.2%; a significantly higher prevalence was found in guangzhou (52.4%) than in the rural ... | 1992 | 1607687 |
| helicobacter colonization and histopathological profile of chronic gastritis in patients with or without dyspepsia, mucosal erosion and peptic ulcer: a morphological approach to the study of ulcerogenesis in man. | helicobacter pylori colonization and the incidence, severity, activity and topography of gastritis were investigated systematically in antrum and corpus mucosal biopsies of 1177 subjects undergoing endoscopy in the absence of gastric complaints (asymptomatic, 49) or for non-ulcer dyspepsia (nud; 631 patients, 72 of whom had gastric and/or duodenal erosions), active gastric ulcer (gu, 76 patients), active duodenal ulcer (du, 138 patients), and healed gastric (hgu, 39 cases) or duodenal ulcer (hdu ... | 1992 | 1609509 |
| helicobacter pylori and peptic ulcer disease. | 1992 | 1610319 | |
| 'gastrospirillum hominis', another gastric spiral bacterium. | 'gastrospirillum hominis' is a 'new' tightly coiled gram-negative bacterium carrying bundles of sheathed polar flagella. it has been rather infrequently detected in antral and, even more rarely, in fundic mucosa samples removed at endoscopy from patients investigated for helicobacter pylori colonization. until now, it has remained noncultivable but has successfully been maintained in laboratory mice. its identity with similar bacteria found in the stomachs of cats, dogs, monkeys, pigs, and other ... | 1992 | 1611710 |
| chemotactic activity of helicobacter pylori sonicate for human polymorphonuclear leucocytes and monocytes. | the immunopathology of helicobacter pylori associated active chronic gastritis, which is characterised by predominance of polymorphonuclear leucocyte infiltration, is largely unknown. to evaluate the role of bacterial components as inflammatory mediators ultracentrifuged sonicated preparations were made of clinical isolates of helicobacter pylori. the crude sonicates were shown to exhibit chemotactic activity for human polymorphonuclear leucocytes and blood monocytes in a concentration dependent ... | 1992 | 1624151 |
| [helicobacter pylori colonization of the gastric remnant following partial resection]. | colonization by helicobacter pylori (hp) in 53 patients after remote gastric surgery and roux-en-y anastomosis was investigated using a rapid urease test (cu-test) and histology (h&e and giemsa stain). the ph-value of gastric juice was measured. hp infection of the gastric remnant was found in 56% of 43 patients after partial resection and in no case after total gastric resection. hp-positive and hp-negative patients were comparable in age, sex distribution, indication and technique of gastric o ... | 1992 | 1626250 |
| [peptic acid disease associated with helicobacter pylori in children. report of a case]. | we studied a child with peptic acid disease which was associated with h. pylori. the identification of h. pylori was done by biopsy and for antibody test. clinical improvement was observed only with the use of amoxocilin and bismuth subsalycilate. | 1992 | 1621037 |
| peptic ulcer disease. | peptic ulcer disease affects between 5 percent and 10 percent of americans during their lifetime. there are a variety of predisposing factors, including nonsteroidal anti-inflammatory drug (nsaid) use, helicobacter pylori infection, tobacco use and, possibly, certain dietary practices. while h2-receptor antagonists remain the mainstay of therapy, the selection of an antiulcer drug should be individualized. famotidine is preferred in persons who use alcohol, sucralfate may be preferred for mainte ... | 1992 | 1621633 |
| the importance of determining both urea and ammonium levels in gastric juice for rapid diagnosis of helicobacter pylori infection. | 1992 | 1612043 | |
| role of sucralfate in peptic disease. | sucralfate, a basic aluminum salt of sucrose, was the first successful drug with a major cytoprotective mechanism of action. it binds bile acids and pepsin and adheres to both ulcerated and nonulcerated mucosa. sucralfate stimulates the synthesis and release of gastric mucosal prostaglandins as well as bicarbonate and the epidermal growth factor which stimulates healing. sucralfate is the safest drug available today in the treatment of dyspeptic symptoms and compared to ranitidine and cimetidine ... | 1992 | 1611711 |
| [helicobacter pylori: from harmless commensal to clinically significant disease factor]. | 1992 | 1611970 | |
| diagnostic efficiency of an ultra-rapid endoscopy room test for helicobacter pylori. | 1992 | 1612370 | |
| subtypes of intestinal metaplasia and helicobacter pylori. | to determine whether there is a relationship between the presence of h pylori and the various subtypes of intestinal metaplasia in the gastric antrum, 2274 antral gastroscopic biopsies from 533 patients were examined. h pylori was found in 289 patients. intestinal metaplasia in general was found in 135 patients. type i intestinal metaplasia was found in 133 patients (98.5%), type ii in 106 patients (78.5%) and type iii in 21 patients (15.6%). ninety eight of these 135 patients (72.6%) were h pyl ... | 1992 | 1612473 |
| ecology of helicobacter pylori in peru: infection rates in coastal, high altitude, and jungle communities. the gastrointestinal physiology working group of the cayetano heredia and the johns hopkins university. | we have examined endoscopic clinic patients in three widely different geographic regions of peru (the coast, the sierra of the andes mountains, and the amazon jungle) for the presence of helicobacter pylori infection associated with active gastritis. the overall rates of infection were high (80% or greater) in all three zones and rates for men were approximately 10% higher than for women in the same zone. men and women in the sierra and jungle areas had significantly higher rates of infection th ... | 1992 | 1612475 |
| hypertrophic gastropathy with transient sessile polyps. | we report an 8-year-old boy with hypertrophic gastropathy (hg) associated with duodenal giardia lamblia infestation. the follow-up was complicated by the development of gastric polyps at the site of previous biopsies that spontaneously disappeared within 15 months. despite the histological similarity, the different course between ménétrier's disease (md) in adults (chronic, with frequent development of sessile or pedunculate polyps) and hg (uncomplicated and usually spontaneously resolving) sugg ... | 1992 | 1619539 |
| protein-losing enteropathy and helicobacter pylori. | 1992 | 1619544 | |
| ebrotidine effect on the proteolytic and lipolytic activities of helicobacter pylori. | 1. the effect of ebrotidine, a new antiulcer agent, on the activity of mucus degrading of protease and lipase enzymes elaborated by helicobacter pylori was investigated. 2. in the absence of ebrotidine, the h. pylori protease caused extensive degradation of gastric mucus protein, while free fatty acids, glycerol mono-oleate and lysophosphatidylcholine were produced by the action of h. pylori lipase and phospholipase a enzymes. 3. introduction of ebrotidine to the incubation system led to the red ... | 1992 | 1639232 |
| serodiagnosis of helicobacter pylori-associated gastritis with a monoclonal antibody competitive enzyme-linked immunosorbent assay. | forty-nine monoclonal antibodies against helicobacter pylori were screened to investigate their capacity to be used in enzyme-linked immunosorbent assay (elisa) competitive systems for the serodiagnosis of helicobacter pylori infection. on the basis of the inhibition pattern showed by the sera of five infected patients, the antibodies were subdivided into five groups. the immunoblotting analysis showed that the antibodies recognized a total of nine different antigenic determinants. in a study of ... | 1992 | 1641587 |
| [helicobacter pylori infections in children]. | in our patient population with chronic aspecific abdominal complaints helicobacter pylori gastritis is no rarity. this entity has been diagnosed in 10 children out of 48 (mean age: 8 years 11 months) who underwent an endoscopy of the upper gastrointestinal tract. after treatment with amoxicillin and colloidal bismuth subcitrate during a period of 2 weeks the complaints disappeared and an eradication was obtained in 7. histology of the antral mucosa demonstrated a type b chronic active gastritis ... | 1992 | 1641843 |
| visual endoscopic indicator of helicobacter pylori infection. | 1992 | 1642216 | |
| a prospective randomized study of the injurious effects of aspirin and naproxen on the gastroduodenal mucosa in patients with rheumatoid arthritis. | a prospective double-blind randomized placebo-controlled study was conducted to compare the injurious effects of aspirin and naproxen on the gastroduodenal mucosa. patients with rheumatoid arthritis attending the immunology clinic of a tertiary care center were included in the study. ninety consecutive patients were randomized to receive aspirin, naproxen, or placebo. clinical evaluation was done every 2 wk. upper gastrointestinal endoscopy, biopsies from the gastric antrum and duodenum for hist ... | 1992 | 1642224 |
| non-immunological defence mechanisms of the gut. | non-immunological defence mechanisms represent an important line of intestinal defence in addition to humoral and cellular immunity. this review summarises the evidence for the role of the non-immunological defence system. protective factors that have been amply documented are gastric juice, intestinal motility, and intestinal flora. components of pancreatic juice, lysozyme, and epithelial cell turnover may also be involved. special attention is given to gastric acid, infection with helicobacter ... | 1992 | 1644343 |
| helicobacter pylori infection in dialyzed patients: bismuth therapy and pharmacokinetics. | 1992 | 1630551 | |
| inhibition of helicobacter pylori glycosulfatase activity toward gastric sulfomucin by nitecapone. | a glycosulfatase activity toward gastric sulfomucin was identified in the extracellular material elaborated by h. pylori. the enzyme exhibited maximum activity at ph 5.7 in the presence of triton x-100 and cacl2, and displayed on sds-page an apparent molecular weight of 30kda. the h. pylori glycosulfatase effectively caused desulfation of n-acetylglucosamine-6-sulfate and galactose-6-sulfate of the carbohydrate chains of mucins, as well as that of glucose-6-sulfate of glyceroglucolipids, but was ... | 1992 | 1632804 |
| helicobacter pylori has an ulcerogenic action in the ischemic stomach of rats. | helicobacter pylori (h. pylori) is now accepted as an important cause of chronic active gastritis. there also seems to be an association between the colonization of h. pylori in the gastric mucosa and peptic ulceration. however, it has not demonstrated that the instillation of h. pylori into the stomach produces the ulcerative gastric lesions in animals or humans. we carried out an experiment to study whether or not h. pylori has an ulcerogenic action in the ischemic stomach of rats, using an ex ... | 1992 | 1629566 |
| helicobacter pylori and gastric lymphonodular hyperplasia in children. | the association of gastric lymphonodular hyperplasia and helicobacter pylori infection has been reported only in children. lymphonodular hyperplasia of the stomach is a well known radiographic and endoscopic entity. over the past three decades, it has been associated with many conditions, ranging from a normal variant to a premalignant lesion. we have recently encountered five children with gastric lymphonodular hyperplasia, all of whom had h. pylori infection of the antrum. the literature regar ... | 1992 | 1728111 |
| diagnosis of helicobacter pylori infection in adult and pediatric patients by using pyloriset, a rapid latex agglutination test. | pyloriset (orion diagnostica, espoo, finland) is a rapid antibody test using latex particles coated with acid-extracted antigen of helicobacter pylori. we evaluated its ability to predict infection in 100 adult patients and 50 pediatric patients referred for gastric endoscopy. sixty of 65 h. pylori-infected adults were correctly identified by the test. there were 12 false-positive and 5 false-negative reactions seen. pyloriset had a sensitivity of 92% and a specificity of 66%. the positive predi ... | 1992 | 1734072 |
| haemagglutination profiles of helicobacter species that cause gastritis in man and animals. | thirty-five helicobacter pylori isolates, 21 h. mustelae isolates and four strains of h. felis were compared for their ability to agglutinate red blood cells (rbcs). isolates were examined in a slide haemagglutination assay with rbcs from 11 animal species, including rodents, carnivores and primates, as well as man. rbcs were agglutinated by 65-90% of h. mustelae isolates and 16-57% of h. pylori isolates. treatment of h. mustelae with pronase and heat inhibited haemagglutination (ha) whereas hea ... | 1992 | 1279175 |
| histamine h2-receptor antagonists in peptic ulcer disease. efficacy in healing peptic ulcers. | duodenal ulcer healing depends on the degree and length of inhibition of gastric secretion and upon the duration of therapy, while gastric ulcer healing is dependent mainly on the duration of therapy. currently marketed doses of the histamine h2-receptor antagonists heal between 77 and 92% of duodenal ulcers at 4 weeks, and adjuvant treatment to eradicate helicobacter pylori increases this rate. once-daily administration is as effective as more frequent dosing regimens and may even result in hig ... | 1992 | 1280563 |
| antigenicity of helicobacter pylori lipopolysaccharides. | an investigation of the sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page) profiles of lipopolysaccharides (lpss) extracted from seven strains of helicobacter pylori revealed that these molecules were silver stainable and exhibited a high degree of variability in their patterns. two strains synthesized a variety of sizes of lps molecules such that fractionation by sds-page resulted in a stepwise gradation of bands which extended from the top to the bottom of the silver-stained ... | 1992 | 1280651 |
| dna fingerprints of helicobacter pylori before and after treatment with omeprazole. | to test whether a hypoacidic environment may potentially "stress" helicobacter pylori dna, encouraging the emergence of strain variation. | 1992 | 1282520 |
| influence of colloidal bismuth subcitrate on enzyme secretion from isolated rat pancreatic acinar cells. | bismuth salts are currently used as monotherapy or in combination with antibiotics for the treatment of helicobacter pylori-associated peptic ulcer disease. besides encouraging clinical results with colloidal bismuth subcitrate (cbs), there is an ongoing fear of organ toxicity with the use of bismuth salts. to study potential toxic effects of cbs under short-term exposure, we tested the influence of cbs on amylase secretion from isolated rat pancreatic acinar cells under basal conditions and fol ... | 1992 | 1282729 |
| role of helicobacter pylori in duodenal ulcer. | 1992 | 1282863 | |
| follicular gastritis and its association with helicobacter pylori infection. | fifty endoscopic biopsies with follicular gastritis (fg) were reviewed to define the frequency of association of fg and helicobacter pylori (h pylori) infection. all biopsies were studied in sections stained with hematoxylin and eosin and no special techniques were employed. in forty-two out of the fifty cases (84%) h pylori was documented and most of the gastritis showed activity. there was no correlation between the quantity of follicles and the number of bacilli; some biopsies with few follic ... | 1992 | 1283226 |
| extranodal lymphomas: the malt concept. | extranodal lymphomas account for as many as 40% of non-hodgkin's lymphomas and most arise in the gastro-intestinal tract which is a major lymphoid organ in its own right. gastrointestinal (gut) associated lymphoid tissue (galt) and that of other mucosae (malt), differs both structurally and functionally from nodal lymphoid tissue and low grade b cell lymphomas arising in the gastrointestinal tract and other mucosae have been found to recapitulate the structure and cytological features of malt. m ... | 1992 | 1283245 |
| [clinical importance of helicobacter pylori infections in childhood]. | within the last ten years an increasing number of helicobacter pylori-related inflammatory gastroduodenal diseases in children has been reported. the aim of this paper is to describe the range of helicobacter pylori infections in children including diagnosis and treatment by application of colloidal bismuth salts. | 1992 | 1289643 |
| does the stomach adapt to helicobacter pylori? | to shed some light on the question of gastric adaptation to helicobacter pylori infection, an overview is given of the various histopathological and clinical consequences of h. pylori infection in man. h. pylori infection can be considered as a chronic bacterial infection. for many individuals there is a balance between a low degree of infection and a low degree of inflammation. the microbial or host factors in adaptation of this balance are largely unknown. if and how 'downregulation' of the in ... | 1992 | 1290055 |
| helicobacter pylori infection and gastroduodenal disease: a comparison of endoscopic findings, histology, and urease test data. | to determine the prevalence and significance of helicobacter pylori (h. pylori) infection, biopsies of the antral mucosa were obtained from 139 patients and 43 asymptomatic volunteers. the specimens were examined by hematoxylin-eosin staining and the ureas test. the detection rate of h. pylori by histologic examination was 91.3% in patients with duodenal ulcer, 75.0% in those with combined duodenal and gastric ulcer, 63.6% in those with gastric ulcer, 22.9% in those with gastric carcinoma, 36.4% ... | 1992 | 1293070 |
| [clinical significance of anti-helicobacter pylori antibody in the diagnosis of helicobacter pylori infection in chronic gastritis]. | 1992 | 1294662 | |
| helicobacter pylori and dyspepsia in an arab population. | to determine the incidence and significance of the detection of helicobacter pylori in an arab population, 116 patients with dyspepsia were studied. 89 percent of these patients had h. pylori detected by culture or/and histological definition of campylobacter-like organisms. by the modified rapid urease test (rut) 80% of the patients had h. pylori (sensitivity of 91%, specificity of 75%). irrespective of the endoscopic diagnosis, the presence of h. pylori was associated with histologic evidence ... | 1992 | 1295138 |
| [association of stomach ulcer and helicobacter pylori. prognostic implications]. | helicobacter pylori is known to be responsible for most cases of chronic gastritis, but its role in the outcome of gastric ulcer is unknown. the purpose of this study was to determine the prevalence of h. pylori infection before and after treatment of gastric ulcer, the micro-organism being untreated. the trial involved 26 patients with an acute episode of gastric ulcer, who had undergone endoscopy with biopsy of the antrum, the fundus and the ulcer rim at the initial examination and then 6 week ... | 1992 | 1297129 |
| hypertrophic protein-losing gastropathy. a retrospective analysis of 40 cases in the netherlands. the dutch ménétrier study group. | hypertrophic protein-losing gastropathy is a rare clinical entity of unknown etiology. seventeen of 50 gi units in the netherlands, surveying their patient material, documented at least 1 positive case. altogether, 40 patients (25 male and 15 female; mean age, 44.3 years) fulfilled the usually accepted criteria. main complaints were epigastric pain (65%), asthenia (60%), anorexia (45%), weight loss 45%, edema (37.5%), and vomiting (37.5%). hypoalbuminemia of < 35 g/l was found in 81%, and an abn ... | 1992 | 1298040 |
| helicobacter pylori: past, present, and future. | helicobacter pylori has now been recognized as one of the most common chronic human infections. it has been accepted as an important aetiologic agent in non-immune chronic gastritis and plays a key role in the aetiology of duodenal ulcer. it may also be involved in the pathogenesis of gastric cancer. | 1992 | 1298043 |
| use of clo test in the detection of helicobacter pylori infection and its correlation with histologic gastritis. | 1992 | 1299736 | |
| gastric intestinal metaplasia in ethnic groups in the southwestern united states. | the incidence of gastric cancer has declined dramatically in the united states during this century. however, the incidence of gastric cancer among hispanics, blacks, and native americans remains 2-3-fold higher than among whites in this country. populations with an increased risk of gastric cancer have predominantly the "intestinal" type of gastric cancer, and intestinal metaplasia is regarded as a histological precursor lesion of this type of gastric cancer. we sought to establish the prevalenc ... | 1992 | 1303129 |
| colloidal bismuth subcitrate in non-ulcer dyspepsia. | the effect of colloidal bismuth subcitrate (de-nol) on symptoms, helicobacter pylori status and histological features was studied in 35 patients with non-ulcer dyspepsia. pain (34 cases) and gas bloat (18) were the predominant symptoms. h pylori was present in 26 (74.3%) patients. gastritis and duodenitis were present in 29 of 32 and 22 of 31 cases respectively in whom biopsies were available. relief in symptoms after treatment was seen in 29 (82.8%) cases. improvement in gastritis and duodeniti ... | 1992 | 1303406 |
| [usefulness of the 14c-urea marked test in the detection of helicobacter pylori in patients with dyspepsia]. | this study was undertaken to evaluate the usefulness of the urea test (ut) in the detection of helicobacter pylori (hp) in dyspeptic patients. the ut was done in 105 patients with dyspepsia who underwent endoscopy and biopsy. hematoxylin-eosin and warthin starry tissue stains were performed for hp detection, and the resulting microscopic findings were considered as the gold standard. the sensitivity, specificity, and positive and negative predictive values of the ut were of 95%, 63%, 85% and 83% ... | 1992 | 1308296 |
| use of polymerase chain reaction-amplified helicobacter pylori urease structural genes for differentiation of isolates. | helicobacter pylori has been demonstrated as an etiologic agent of human gastritis and peptic ulcer formation. however, there is no straightforward basis to distinguish different isolates. we used the polymerase chain reaction (pcr) to amplify the urease structural subunit genes, urea and ureb, which, when digested with appropriate restriction endonucleases, allow the differentiation of patterns on agarose gels. pcr amplification was possible with dna rapidly extracted from h. pylori by alkaline ... | 1992 | 1313051 |
| expression of helicobacter pylori urease genes in escherichia coli grown under nitrogen-limiting conditions. | helicobacter pylori produces a potent urease that is believed to play a role in the pathogenesis of gastroduodenal diseases. four genes (urea, ureb, urec, and ured) were previously shown to be able to achieve a urease-positive phenotype when introduced into campylobacter jejuni, whereas escherichia coli cells harboring these genes did not express urease activity (a. labigne, v. cussac, and p. courcoux, j. bacteriol. 173:1920-1931, 1991). results that demonstrate that h. pylori urease genes could ... | 1992 | 1313413 |
| [acid-peptic disease associated with helicobacter pylori in children. report of a case]. | 1992 | 1308293 | |
| helicobacter pylori in experimental acute and chronic gastric and duodenal ulcer in buffalo [correction of bufallo] rats. | the experiment was performed using inbred buffalo rats to confirm the coincidence between peptic, gastric and duodenal ulcer and helicobacter pylori infection. the results suggest an unquestionable meaning of helicobacter pylori appeared to be as strong ulcerogenic factor in rats as ligation of pylorus and diffusely administrated histamine. | 1992 | 1308048 |
| construction of isogenic urease-negative mutants of helicobacter pylori by allelic exchange. | isogenic urease-negative mutants of helicobacter pylori were constructed by allelic replacement. a region of cloned h. pylori dna containing the structural urease genes (urea and ureb) was disrupted by insertion of a mini-tn3-km transposon. electrotransformation of h. pylori cells with kanamycin-ureb-disrupted derivative plasmids resulted in isolation of kanamycin-resistant h. pylori transformants. competence for electrotransformation appeared to be restricted to certain wild-type h. pylori isol ... | 1992 | 1320607 |
| helicobacter pylori and gastroduodenal disorders. | 1992 | 1334317 | |
| helicobacter pylori, chronic gastritis and peptic ulcer. | h. pylori infection is strongly associated with chronic gastritis and is probably the main course of chronic inflammation in the gastric mucosa. acquisition of the infection will lead to gastritis and the eradication of the bacterium results in healing and final cure of the gastritis. chronic gastritis and h. pylori infection may occur in antrum and/or corpus, and will gradually result in atrophy of the underlying mucosa in a great number of affected persons. correspondingly, impairments in seve ... | 1992 | 1307646 |
| comparison of three different methods for evaluation of helicobacter pylori (h.p.) in human dental plaque. | helicobacter pylori (h.p.) is a microorganism involved in peptic ulcer disease. to clarify the role of human dental plaque as a reservoir of h.p. and to compare different methods of investigation the authors studied 20 patients, 17 males main age 56 +/- 12 and 3 females 52 +/- 7, gastro-duodenal h.p. positive. the trial was carried out by cultural, biochemical and microscopical plaque analysis. cultural and microscopical method were h.p. positive in 80% patients, urease in 100%, alkaline phospha ... | 1992 | 1307023 |
| [helicobacter pylori in barrett esophagus]. | the authors evaluated the prevalence of colonize by helicobacter pylori in 21 adults patients with barrett's esophagus; 12 males and 9 females; with ranges of age from 21 to 81 years and a medium of 56.4 years old. it was detected in 23.8% that helicobacter pylori was positive in barrett's esophagus, being quite higher, 26.6% in patients over 50 years old. in the five cases with positive helicobacter pylori, the barrett esophagus presented a fundic gastric mucosa and no one intestinal metaplasia ... | 1992 | 1340675 |