Publications

plasma protein synthesis in experimental cancer compared to paraneoplastic conditions, including monokine administration.	during tumor growth, there are characteristic alterations in the concentration and synthesis of various plasma proteins. the purpose of this study was to evaluate whether these changes are unique to a tumor-bearing state, or rather, they represent a generalized response to a paraneoplastic state mediated by the release of monokines or protein-calorie malnutrition. plasma protein synthesis and concentrations in mice bearing a transplantable fibrosarcoma were compared to animals receiving either a ...	1987	3117356
incomplete surgery, local immunostimulation, and recurrence of some tumour types in dogs and cats.	histologically confirmed inadequate treatment resulted in a lower than expected recurrence percentage in dogs with haemangiopericytoma (38%) and mastocytoma (30%). clinical suspicion of inadequate tumour treatment did not always correlate with the histologically assessed inadequacy, nor with the appearance of local recurrence. local recurrence did not seem to be correlated with histological grade of malignancy and tumour size. local injection of c. parvum vaccine did not result in a lower percen ...	1987	3118558
induction of interleukin 1 secretion and of tumoricidal activity in macrophages are not closely related phenomena.	rat bone marrow-derived mononuclear phagocytes (bmm phi), induced to differentiate in vitro and homogeneous with respect to the cell lineage, were interacted with various macrophage-activating agents. the effect of these agents on the secretion of interleukin 1 (il 1) activity and on the development of tumoricidal capacity was comparatively assessed. the findings show that il 1 secretion is considerably enhanced by macrophage-activating factor and by recombinant interferon-gamma but remained una ...	1987	3119353
a study on the adhesive properties of cor. diphtheriae and cor. parvum in the direct haemagglutination reaction.	the adhesive properties of one cor. parvum and two cor. diphtheriae strains were investigated by means of the direct haemagglutination reaction (har). using a specifically developed har procedure, it was proved beyond doubt that the studied corynebacteria possess adhesive properties apparently associated with the presence of pili (fimbrias) on their surfaces. in addition, a correlation was found between the agglutinating activity of bacteria and the conditions of culture growth. based on the rep ...	1987	3119703
propionibacterium acnes: a neglected head and neck pathogen.		1987	3120131
cytopathogenic protein in filtrates from cultures of propionibacterium acnes isolated from patients with kawasaki disease.	propionibacterium acnes may have a role in kawasaki disease. filtrates from cultures of p acnes isolated from cervical lymph node biopsy specimens and blood samples from patients with kawasaki disease were studied and compared with samples from control subjects. after inoculation of human embryo liver cells with filtrates from the patients a cytopathogenic effect and vacuolation were seen. a specific cytopathogenic substance was found in only the filtrates of cultures from patients with kawasaki ...	1987	3120957
modulation of beta-galactosidase activity in peritoneal macrophages from c57b1 mice after exposure to proprionibacterium acnes.	peritoneal macrophages (pm luminal diameter) from untreated c57b1 mice contain high levels of beta-galactosidase (beta-gal) and these pm luminal diameter are heterogeneous in their expression of this enzyme. intraperitoneal (i.p.) injection of saline caused a transient depression in the level of enzyme activity in the pm luminal diameter whereas i.p. injection of proprionibacterium acnes (p. acnes) gave rise to a marked decrease of beta-gal activity in these cells. this reduction in enzymatic ac ...	1987	3122521
hepatic reticuloendothelial system activation in autoimmune mice: differences between (nzb x nzw)f1 and mrl-lpr/lpr strains.	5'-nucleotidase (5'n) activity and ia expression of hepatic nonparenchymal cells (npcs) of the autoimmune (nzb x nzw)f1 and mrl-lpr/lpr and nonautoimmune c3h/fej, dba/2j, and a/j strains were assayed to determine endogenous activation of the hepatic reticuloendothelial system (res). pretreatment of the nonautoimmune strains with corynebacterium parvum resulted in decreases in fc receptor expressor and 5'n and an increase in ia expression of npcs. endogenous hepatic res activation, as measured by ...	1987	3030589
the immunological activities of components isolated from corynebacterium parvum in mice injected with polyoma tumor cells.	the inhibition of polyoma tumor in cba mice after immunization with different fractions of corynebacterium parvum was investigated. treatment with 200 micrograms of polysaccharide from culture filtrate before s.c. inoculation 2 x 10(6) of tumor cells induced antitumor effect in mice. treatment with lower doses (1 microgram or 20 micrograms) after transplantation of tumor cells was not effective. injection of lipopolysaccharide from escherichia coli abolished a positive response on inhibition of ...	1987	3031518
encephalomyocarditis (emc) virus-induced diabetes mellitus prevented by corynebacterium parvum in mice.	corynebacterium parvum prevented the development of encephalomyocarditis virus-induced diabetes in mice, when it was given 3-14 days before the virus infection. this treatment inhibited virus replication in the pancreas of the infected mice at an early stage of the infection.	1987	3032672
methadone vs morphine: comparison of their effect on phagocytic functions.	a comparison of the effects of methadone and morphine on phagocytic physiology was carried out in mice, using a number of tests, to estimate the risk of using methadone in maintenance protocols for opiates addicts. results indicate that methadone, like morphine, reduces (a) r.e.s. activity and (b) pmn superoxide anion production, while unlike morphine it (a) does not produce haematologic changes, (b) does not exacerbate c. albicans infections, (c) does not inhibit phagocytosis and killing by mur ...	1987	3034811
antigen-specific suppression of the in vitro cytotoxic response by a soluble factor produced by corynebacterium parvum-induced allospecific suppressor cells.	the adjuvant corynebacterium parvum, when administered intravenously during an ongoing alloimmunization, induces alloantigen-specific splenic suppressor cells which inhibit primary and secondary in vitro sensitizations. we have previously shown that these cells produce a soluble suppressor factor in culture. we now further characterize this factor and its mechanism of action. release of this suppressive factor is dependent upon specific restimulation of the splenic suppressor cell with the sensi ...	1987	2949854
uptake of protoporphyrin and violet light photodestruction of propionibacterium acnes.	the uptake of protoporphyrin ix by propionibacterium acnes in suspension has been studied by fluorescence spectroscopy. protoporphyrin, after it was injected into a cell suspension, was firstly bound to receptors on the cell surface and in this state protoporphyrin was non-fluorescent. subsequently, probably as a result of lateral diffusion in the cell wall, these protoporphyrin-receptor complexes formed dimers. the final step in the overall uptake process of protoporphyrin by the cells from the ...	1987	2953128
no photoinactivation of propionibacterium acnes with soft laser treatment.		1987	2956136
antibodies to p. acnes and p. acnes exocellular enzymes in the normal population at various ages and in patients with acne vulgaris.	total serum igm and igg agglutinins to p. acnes and neutralizing antibodies to p. acnes lipase, hyaluronate lyase and acid phosphatase were measured in normal individuals of different age groups. agglutinins to p. acnes were detected in infants at 4 months of age and were present at a high level throughout life. a switch from predominantly igm agglutinins in children, to igg agglutinins in adults, occurred during adolescence. anti-p. acnes lipase antibodies were present in 20% of teenagers and 1 ...	1987	2956986
[pathomechanism, bacteriology and treatment of acne changes].		1987	2957292
the production of inflammatory compounds by propionibacterium acnes and other skin organisms.	culture supernatants from four species of skin microorganisms (p. acnes, p. avidum, p. granulosum and s. epidermidis) were assayed for smooth muscle contracting substances which are indicative of inflammatory activity. at least three types of smooth muscle contracting substances were detected. these were: first, a substance active on a rat fundic strip preparation and antagonized by n,n-dmt. activity was enhanced when cultures were grown in the presence of tryptophan. this substance was probably ...	1987	2958076
[occurrence and levels of serum antibodies against propionibacterium antigens in persons of various ages].		1987	2959828
in vitro activity of vancomycin and teicoplanin against anaerobic bacteria.	the in vitro activity of vancomycin and teicoplanin, a new glycopeptide antimicrobial, was determined against a total of 286 anaerobic bacteria including bacteroides fragilis group (100), b. melaninogenicus (21), b. bivius (16), fusobacterium spp. (15), peptococcus spp. (20), peptostreptococcus spp. (21), clostridium perfringens (23), c. difficile (41) and propionibacterium acnes (29). minimum inhibitory concentrations (mic) were determined using an antimicrobial incorporation technique in wilki ...	1987	2962846
azelaic acid.	this review is an update on the literature accumulated over the past 10 years following the original observation that azelaic acid, a naturally occurring and nontoxic c9 dicarboxylic acid, possesses significant biologic properties and a potential as a therapeutic agent. these studies have shown that azelaic acid is a reversible inhibitor of tyrosinase and other oxidoreductases in vitro and that it inhibits mitochondrial respiration. it can also inhibit anaerobic glycolysis. both in vitro and in ...	1987	2963038
patterns of failure in patients with resected stage i and ii non-small-cell carcinoma of the lung. the ludwig lung cancer study group.	the pattern of failure was studied in 1012 patients with resected stage i or ii non-small-cell carcinoma of the lung. initial intrathoracic failure (41%) was more common than initial extrathoracic failure (34%) even though a complete resection was the intent in all patients. the most frequent sites of initial failure were the bronchial resection line (16%) and the central nervous system (cns) (15%). the site distribution of initial failure does not appear to depend on tnm stage or pattern of nod ...	1987	3026260
the microbial colonization of inflamed acne vulgaris lesions.	seventy one papules in the early stages of inflammatory development were isolated from acne vulgaris affected skin and their content of micro-organisms characterized. the progress of lesions prior to excision was monitored by tracing an area of the upper back onto a transparent acetate sheet. this template was used the next day, and in some cases after 3 days, to identify inflamed lesions of less than 1 day and 2-3 days duration. these were biopsied, and pilosebaceous units isolated by micro-dis ...	1988	2964856
[propionibacterium acnes septicemia in a mycosis fungoides].		1988	2970819
the antibiotic susceptibility of propionibacterium acnes: a 15-year bacteriological study and retrospective evaluation.		1988	2971698
acne vulgaris and malignancy.	seventy patients with lymphomas and leukaemias were interviewed. details of past acne vulgaris were recorded and a clinical examination performed. a history of acne was less common in the patients than in matched controls. in addition, fewer patients had received treatment prescribed by a medical practitioner for their acne than had the controls. examination revealed fewer patients with acne. these results suggest a reduced incidence of acne or its more severe forms in patients who have develope ...	1988	2974720
granulocyte activating factor released from propionibacterium acnes. a possible mediator of inflammation in acne vulgaris.	incubation of propionibacterium acnes but not of propionibacterium granulosum or propionibacterium avidum (for 30 min at 37 degrees c in physiological saline) released a soluble factor that produced enhanced chemiluminescence response of human granulocytes as well as increased chemotactic motility of these cells. sephadex g-25 filtration of the granulocyte activating factor (gaf) revealed its low molecular weight and apparent peptide character. thus, gaf may be a stimulus for inflammation in acn ...	1988	2975904
bone marrow derived macrophages have polyamine and ectoenzyme phenotypes distinct from resident macrophages.	several prototype macrophage (mo) populations were compared for differences in ectoenzyme phenotype and polyamine content. resident peritoneal mo and corynebacterium parvum (cp)-activated peritoneal mo expressed unique ectoenzyme phenotypes, while bone marrow derived mo (bmdmo), obtained from stem cells after 7 days in culture with colony stimulating factor, and thioglycollate (tg)-elicited peritoneal mo exhibited a similar ectoenzyme phenotype. all of the mo populations, however, differed in po ...	1988	2835568
effect of macrophage activation on resistance of mouse peritoneal macrophages to infection with herpes simplex virus types 1 and 2.	to define the effect of heterogeneity of murine peritoneal macrophages (m phi) on intrinsic resistance to herpes simplex virus (hsv) infection, several m phi populations were characterized for their response to infection with hsv type 1 (hsv-1) and hsv-2. steady-state resident m phi (res m phi) were compared in parallel with m phi activated with corynebacterium parvum (now designated propionibacterium acnes) (cp m phi) and thioglycollate-elicited inflammatory m phi (tg m phi). res m phi were com ...	1988	2841412
effect of endotoxin on release of reactive oxygen intermediates by rat hepatic macrophages.	reactive oxygen intermediates released by activated hepatic macrophages have been implicated in the pathogenesis of a rat model of liver injury induced by sequential administration of corynebacterium parvum and endotoxin. in this model, c. parvum causes extensive infiltration of the liver with activated macrophages, but severe liver injury occurs only after subsequent exposure to endotoxin. we have therefore investigated the effects of endotoxin on the release of reactive oxygen intermediates by ...	1988	2846404
influence of immunomodulatory agents on bovine humoral and cellular immune responses to parenteral inoculation with bovine rotavirus vaccines.	sodium diethyldithiocarbamate (dtc), mycobacterium cell wall extract (mcwe, regressin), killed corynebacterium parvum (c. parvum, immunoregulin) and muramyldipeptide (mdp) were each combined with purified, live bovine rotavirus and inoculated into 3 month-old holstein-friesian calves in order to examine their ability to potentiate specific humoral and cellular immune responses. the vaccinated calves were boosted twice at 3 and 6 weeks after initial vaccine inoculation. the rotavirus was administ ...	1988	2847397
[in vitro activity of an ofloxacin-metronidazole combination against anaerobic bacteria. kinetics of the action of metronidazole against bacteroides fragilis].	the activity of metronidazole combined with ofloxacin was investigated by the checkerboard method in liquid medium against 60 obligate anaerobes. the bacteriostatic effect of the combination was assessed by calculating the fic index. two metronidazole resistant strains of propionibacterium acnes (mic greater than 32 mg/l) were inhibited by 0.125 mg/l of this former antibiotic in presence of an ofloxacin concentration equal to half the value of the mic. on the 58 other anaerobic strains, the comb ...	1988	3043345
diagnosis and treatment of chronic postoperative bacterial endophthalmitis.	chronic postoperative bacterial endophthalmitis has recently assumed a prominent role in differential diagnosis of inflammation following extracapsular cataract extraction with posterior chamber intraocular lens implantation. the optimal diagnostic and therapeutic approach to this entity has not yet been clearly defined. we present a case of chronic postoperative propionibacterium acnes endophthalmitis in which the diagnosis was made by anterior chamber paracentesis, and topical, periocular, and ...	1988	3050671
differential effect of inflammatory stimuli on murine plasma c4 and factor b concentrations.	the in vivo effects of a variety of inflammatory stimuli on complement c4 and factor b plasma levels have been examined. mrl/++ (h-2k) mice were given intraperitoneal injections of lipopolysaccharide, turpentine, corynebacterium parvum pyridine extract residue or high doses of indomethacin. all of these treatments induced an increase in plasma factor b concentrations, which in the case of c. parvum was dose dependent and persisted for at least 7 days. lipopolysaccharide, turpentine and indometha ...	1988	3052973
differences between beige and bg/+ mice in the disruption of plasma proteinase regulation in the tumor-bearing state or following corynebacterium parvum treatment. evidence for the involvement of polymorphonuclear leukocyte proteinases.	mice bearing the b16 melanoma or treated with corynebacterium parvum develop elevated levels of plasma neutral proteinase activity. similar experiments carried out with c57bl/6-bg/bg (beige) mice, which are genetically deficient in polymorphonuclear neutrophil (pmn) proteinases, revealed that such mice develop significantly diminished elevation in plasma proteinase activity compared to c57bl/6-bg/+ mice. lysates of c. parvum elicited pmn from beige mice contained approximately 80% less neutral p ...	1988	3053356
palmoplantar pustulosis and sternocostoclavicular arthro-osteitis.	seventeen patients with shoulder pain and radiographic involvement of the sternoclavicular or sternocostal joints, or both, are described. eleven of these patients also had palmoplantar pustulosis. histological examination of the joints showed chronic and subacute inflammation, increased osteoblastic activity, and cartilage degeneration. propionibacterium acnes was cultured in tissue samples from seven of the 15 biopsied patients, a finding at variance with those of previous reports. the possibi ...	1988	3058054
[chronic endophthalmitis caused by propionibacterium acnes in a pseudophakic patient].	this paper reports the case of a chronic endophthalmitis with hypopion produced by propionibacterium acnes (p. a.) in a patient operated on for cataract and implanted with a posterior chamber intraocular lens. this granulomatous uveitis appeared 8 days after surgery and did not heal with a systemic corticoid-antibiotics treatment. the diagnosis was obtained by vitreous analysis. the responsibility of p. a. must be always searched in case of chronic endophthalmitis in pseudophakic patients: a spe ...	1988	3062063
[propionibacterium acnes in the biopsied lymph nodes of sarcoidosis patients demonstrated by an immunofluorescence and immunoperoxidase staining technics].		1988	3066938
[preliminary results of studies of the effect of immunostimulation combined with chemotherapy in patients with ovarian cancer].		1988	3069616
serotherapy of ovarian cancer.	the development of monoclonal antibodies has permitted the identification of several ovarian-tumor-associated antigens which might serve as targets for serotherapy in vivo. with the exception of antibodies directed against growth factor receptors, unmodified monoclonal reagents must activate complement (c') components or bind effector cells to destroy tumor targets. antibody-dependent cell-mediated cytotoxicity (adcc) may be particularly important for eliminating tumor cells in vivo. a shortage ...	1988	3070370
immunologic control of ovarian cancer.		1988	3070371
contribution of the microflora to proteolysis in the human large intestine.	protease activities in human ileal effluent were approximately 20-fold greater than in normal faeces. comparative studies with faeces from a person who did not have a pancreas suggested that a substantial proportion of the proteolytic activity in normal faeces was of bacterial origin. thimerosal, iodoacetate, edta and cysteine significantly inhibited proteolysis in faeces, but not in small intestinal contents, showing that cysteine and metalloproteases were produced by bacteria in the large gut. ...	1988	3127369
antitumor effect of normal intestinal microflora on ehrlich ascites tumor.	in order to investigate the antitumor activity of intestinal microflora, the constitution of normal flora was examined in humans, guinea pigs and mice. it was clarified that eubacterium, bifidobacterium and bacteroides were the predominant bacterial genera in humans. in addition, neither clostridium nor enterobacteriaceae was detected in guinea pigs and neither clostridium nor bifidobacterium was present in mice. total bacterial counts in tumor-bearing mice were reduced in comparison with those ...	1988	3128498
the influence of adjuvant on induction of protective immunity by a non-living vaccine against schistosomiasis.	mice were protected against subsequent infection with schistosoma mansoni by intradermal or s.c. vaccination with killed schistosomula or soluble parasite extracts and bacillus calmette-guérin (bcg). treatment with i.p. immunization was somewhat less effective, whereas i.m. vaccination failed to elicit protective immunity. the level of resistance induced by intradermal immunization was influenced by the strain of bcg used, and isolated bcg cell walls did not reliably substitute for whole bcg org ...	1988	3128608
the microbial content and complement c3 cleaving capacity of comedones in acne vulgaris.	complement c3 deposition around lesions is an early event in the inflammation of acne vulgaris. the aims of this study were to determine the relationship between the capacity of individual comedones to cleave complement c3 and their microbial flora. the contents of 48 open comedones were expressed from the upper back of acne vulgaris patients and each comedo was homogenized individually and assayed for microbial content and capacity to induce cleavage of complement c3 in an in vitro assay system ...	1988	2467483
antimicrobial properties of kupffer cells.	to characterize the antimicrobial activities of kupffer cells, i harvested macrophages from livers with a technique involving perfusion with collagenase and dnase. ninety-nine percent of glass-adherent cells had typical macrophage morphology, 99% were esterase positive, and 60% phagocytosed opsonized zymosan when challenged with four particles per macrophage. toxoplasma gondii multiplied within kupffer cells from unmanipulated mice, but multiplication was intermediate between that observed in hi ...	1988	3131244
prosthetic valve endocarditis caused by propionibacterium acnes.		1988	3132285
protective effects of a leukotriene inhibitor in an experimental massive hepatic cell necrosis model.	when heat-killed propionibacterium acnes was intravenously injected into mice and seven days later, a small amount of gram-negative lipopolysaccharide was also intravenously injected, most of them died of massive hepatic cell necrosis. however, when azelastine hydrochloride, a leukotriene antagonist chemically known as 1(2h)-phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1h-azepine-4-yl)-, monohydrochloride, or aa861, 2-(12-hydroxydodeca-5, 10-diynyl)-3,5,6-trimethyl-1, 4-benzoq ...	1988	3136049
alteration of non-specific resistance to infection with listeria monocytogenes.	the experimental infection of murine hosts with listeria monocytogenes is often used as a model for cell-mediated immunity. however, the natural immunity or non-specific resistance to listeriosis can be influenced by the parasite itself and also by a wide array of endogenous and exogenous host factors. the most important host factor in inbred mouse strains is their genetically determined susceptibility or resistance to listeria monocytogenes. secondly, the age of the mice is crucial for the outc ...	1988	3138182
effect of psk, a protein-bound polysaccharide from coriolus versicolor, on drug-metabolizing enzymes in sarcoma-180 bearing and normal mice.	the effects of psk and propionibacterium acnes (anaerobic corynebacterium) on hepatic drug-metabolizing enzymes were studied using sarcoma-180 bearing and non-tumor bearing mice. psk had no influence on aminopyrine n-demethylase and aniline hydroxylase activities, cytochrome p-450 concentration in hepatic microsomes, and the reductase activity of cytochrome c in normal mice. the content of cytochrome p-450 was not significantly reduced in s-180 bearing mice. on the other hand, p. acnes administr ...	1988	3139576
comparison of efficacy of mitomycin-c and corynebacterium parvum in the management of malignant pleural effusion.		1988	3150706
[the use of corynebacterium parvum in pleurodesis].		1988	3168834
ocular dangers in the garden. a new menace--nylon line lawn trimmers.	nylon line lawn trimmers represent a source of potentially devastating ocular trauma. five cases of ocular trauma associated with the use of line trimmers are reported. these case reports document new mechanisms and circumstances of injury, including trauma from debris other than nylon line fragments and injury to bystanders. furthermore, injuries are often serious, with two of these patients requiring an evisceration or enucleation after endophthalmitis developed. in one patient, six different ...	1988	3174040
effects of the polysaccharide chain of lipopolysaccharide in an experimental massive hepatic cell necrosis model.	when small amounts (1 microgram) of lipopolysaccharide (lps) purified from salmonella minnesota (sm) wild, sm r60 and sm r345 were intravenously injected into mice 7 days after heat-killed propionibacterium acnes was intravenously injected, massive hepatic cell necrosis was induced and most of the mice died within 24 hours. however, when lps from sm r345 treated galactosidase, sm r5 and sm r7 and lipid a from sm r595 were administered, the survival rate was much higher and no histological change ...	1988	3178810
effects of the polysaccharide chain of lipopolysaccharide in an experimental massive hepatic cell necrosis model in the mice.	when a small amount (1 microgram) of lipopolysaccharide (lps) purified from salmonella minnesota wild, salmonella minnesota r60, and salmonella minnesota r345 was intravenously injected into mice 7 days after heat-killed propionibacterium acnes was intravenously injected, massive hepatic cell necrosis was induced and most of the mice died within 24 hours. however, when lps from salmonella minnesota r5 and salmonella minnesota r7 and lipid a from salmonella minnesota r595 were administered, the s ...	1988	3181665
bacteriological findings of acute maxillary sinusitis in young adults.	bacteriological findings in 339 sinus secretions obtained by puncture were investigated in 238 young adult patients with acute maxillary sinusitis. aerobic and anaerobic cultures were performed immediately. a total of 76% of the secretions were positive. the most common pathogens isolated were haemophilus influenzae (50%), streptococcus pneumoniae (19%), streptococcus pyogenes (5%), and branhamella catarrhalis (2%). coagulase-negative staphylococci and staphylococcus aureus were isolated in 8 an ...	1988	3182986
corynebacterium parvum as palliative treatment in malignant ascites.		1988	3183831
role of anaerobic bacteria in aortofemoral graft infection.	a 10-year review of specimens of aortofemoral graft infection sent to the microbiology laboratory for cultures of anaerobic bacteria revealed the presence of these organisms in 13 of 16 specimens. nineteen organisms (1.5 per patient) were isolated: 16 anaerobes and 3 aerobes. the predominant bacteria were anaerobic gram-positive cocci (six isolates), propionibacterium acnes (five), and bacteroides fragilis group (four). polymicrobial infection was present in three patients, all with decubitus ul ...	1988	3187899
tumor necrosis factor/cachectin. induction of hemorrhagic necrosis in normal tissue requires the fifth component of complement (c5).	tnf induces hemorrhagic necrosis (hn) when injected into skin exposed to bacterial agents but not when injected into normal skin. in this paper, we present several lines of evidence suggesting that tnf requires the fifth component of complement (c5) to induce hn in skin exposed to bacteria. first, mouse strains that do not have c5 did not develop hn after injection of tnf and bacteria into skin. second, plasma from c5-sufficient mice could correct the defect in these c5-deficient mice. third, he ...	1988	3199066
in vitro activity of flomoxef compared to moxalactam, cefoxitin, cefotaxime, and clindamycin against anaerobes.	to assess the in vitro activity of flomoxef (6315-s), moxalactam, cefoxitin, cefotaxime, and clindamycin against anaerobes 197 clinical isolates (27 bacteroides fragilis, 42 b. thetaiotaomicron, 10 b. vulgatus, 7 b. ovatus, 6 b. uniformis, 6 b. distasonis, 7 bacteroides melaninogenicus group, 11 bacteroides oralis group, 21 clostridium difficile, 7 c. perfringens, 3 c. sporogenes, 3 clostridium spp., 33 propionibacterium acnes, 14 peptococcaceae) were studied by means of agar dilution tests. the ...	1988	3214438
age and lpr dependent induction of increased sensitivity to the toxic effects of lipopolysaccharide and indomethacin in mrl mice: evidence for res activation during disease progression.	injection of 4.5-6 month old female mrl-lpr/lpr mice with 200-250 micrograms lipopolysaccharide led to the death of the animals within two days. treatment of age matched female control mice (mrl-+/+) or young (3 month) mrl-lpr/lpr mice did not lead to similar toxicity. however, pretreatment of young mice with the pyridine extract of residue of corynebacterium parvum (alternatively designated propionibacterium acnes) prior to lipopolysaccharide injection, led to the rapid death of 100% of the mic ...	1988	3230580
properties and characteristics of a bacteriocin-like substance produced by propionibacterium acnes isolated from dental plaque.	a cell-associated bacteriocinlike substance with an approximate molecular weight of 78,000 was isolated from an oral isolate of propionibacterium acnes. the substance was bacteriostatic and was active against both gram-positive and gram-negative anaerobes. lysozyme inhibited the activity of the bacteriocinlike substance at low ionic strength.	1988	3233559
characteristics of the hepatocytotoxic factor in mice with experimentally-induced massive hepatic cell necrosis.		1988	3248030
endophthalmitis following nd:yag laser posterior capsulotomy.	we report the development of propionibacterium acnes endophthalmitis following nd:yag laser posterior capsulotomy. the patient previously underwent uncomplicated extracapsular cataract extraction with intraocular lens insertion and was free of inflammation prior to laser capsulotomy. diagnostic vitrectomy and aqueous tap were performed, and p. acnes was isolated from the aqueous in thiol broth media after nine days of incubation under anaerobic conditions. the patient was managed with topical an ...	1988	3258419
propionibacterium acnes.		1988	3261615
eradication of syngeneic tumor (meth a fibrosarcoma) from mice by adoptive immunotherapy of immunized spleen cells induced by corynebacterium parvum-pyridine extract residue.	eradication of immunologically-syngeneic tumors was achieved by adoptive chemotherapy using effector cells induced by corynebacterium parvum-pyridine extract residue (cp-per). a mixture of 2 x 10(6) meth a cells and 0.1 mg cp-per was subcutaneously inoculated into the back of donor balb/c mice, with the result that their spleen cells showed an antitumor effect 10 to 13 days after the inoculation. these cells were used as immune cells. recipient mice were inoculated with 1 x 10(6) meth a cells, a ...	1988	3266420
[in vitro experiments with respect to the invasiveness of propionibacterium acnes into human teeth].		1988	3269190
tissue localization and kinetics of pit cells or large granule lymphocytes in the liver of rats treated with biological response modifiers.	the numbers of kupffer cells (macrophages) and pit cells (large granular lymphocytes) were counted by light and electron microscopy in perfusion-fixed liver sinusoids. after a single intravenous injection of the biological response modifiers zymosan, propionibacterium acnes and ok-432, a 4- to 6-fold increase in the number of pit cells and a 2- to 4-fold increase in the number of kupffer cells were observed within a period of 4 to 7 days. the mechanisms of the pit cell accumulation were further ...	1988	3276590
antitumour effects of streptococcal lipoteichoic acids on meth a fibrosarcoma.	the antitumour effects of lipoteichoic acids (lta) extracted from streptococcus pyogenes were studied in comparison with other streptococcal cellular components. lta suppressed the tumour growth of both solid- and ascites-type meth a fibrosarcoma as did the whole cells of s. pyogenes (ok-432). no other cellular components, such as cell wall peptidoglycan, group-specific c-carbohydrate or type-specific m protein, suppressed the growth of meth a. lta, but not the other cellular components, induced ...	1988	3279996
phototoxicity of skin microorganisms tested with a new model.	a new standardized method for testing phototoxicity of chemicals against microorganisms is described. the inoculum size of the microorganism, application of test chemicals, prediffusion time, incubation time and incubation period are defined. staphylococcus aureus, s. epidermidis, candida albicans, and pityrosporum orbiculare were studied. both 8-methoxypsoralen and trimethylpsoralen were phototoxic against all microorganisms tested, while tetracycline and doxycycline were not phototoxic. c. alb ...	1988	3288127
treatment of malignant pleural effusions with intracavitary corynebacterium parvum.	fifty-three cases of metastatic pleural effusion (30 haemorragic and 23 serofibrinous) were treated with 4 mg of corynebacterium parvum (cp) injected weekly into the pleural cavity after total thoracentesis. of the 53 effusions, 24 were metastases from lung cancer and 29 from breast cancer. complete response (cr) was assessed as total resolution of pleural effusion after explorative thoracentesis. the results were as follows: 15 cr after two injections of cp, 30 cr after three, and 5 cr after th ...	1988	3293763
prevention of peroral and congenital acquisition of toxoplasma gondii by antibody and activated macrophages.	intramuscular administration of toxoplasma gondii lysate antigens to mice produced titers of t. gondii-specific antibody (measured by sabin-feldman dye test) greater than or equal to 1:1,024 in their sera. intravenous administration of heat-killed propionibacterium acnes to mice produced peritoneal macrophages with enhanced microbicidal capacity against t. gondii. mice with high antibody titers or activated peritoneal macrophages or both had reduced numbers of toxoplasma cysts in their brains 30 ...	1988	3335411
studies on the endogenous flora of the human breast.	identification of the endogenous microbiological flora of the human breast and its role in breast infections following subglandular augmentation or reduction mammaplasty was undertaken. a total of 231 cultures were performed on 59 breasts in 30 patients. patients were followed for 12 months. no fungus was cultured from any specimen. of the breasts cultured 53% were positive for coagulase-negative staphylococcus. other aerobes found included diphtheroids, lactobacillus, d-enterococcus, micrococcu ...	1988	3341714
experimental immunological intrahepatic cholestasis model.	heat-killed propionibacterium acnes (p. acnes) was intravenously injected into tuberculin-sensitized guinea pigs, and 7 days later, purified protein derivative (ppd) was also injected intravenously resulting in marked reductions in bile flow and bile acid excretion. serum levels of bile acids and cholesterol were increased, and the activities of alkaline phosphatase (alk-p) and leucine aminopeptidase (lap) were also elevated. histological examination revealed dilatation of bile canaliculi and di ...	1988	3350277
aerobic and anaerobic bacteriology of purulent nasopharyngitis in children.	cultures of aerobic and anaerobic bacteria were obtained from the inferior nasal meatus of 25 children with purulent nasopharyngitis and from 25 controls. microorganisms were isolated from all specimens. a total of 98 isolates (3.9 per patient), 45 aerobes (1.8 per patient) and 53 anaerobes (2.1 per patient), were isolated in patients with purulent nasopharyngitis. seventy-three isolates (2.9 per patient), 47 aerobes (1.9 per patient) and 26 anaerobes (1.0 per patient) were found in the controls ...	1988	3356794
propionibacterium acnes lens abscess after traumatic implantation of intralenticular cilia.		1988	3358438
correction of defective tumoricidal activity of macrophages from a/j mice by liposomal immunomodulators.	the ability of liposomal immunomodulators to restore abnormal macrophage tumoricidal activity has been studied. macrophages from a/j mice have impaired responses in vitro to macrophage activating factor, gamma-interferon, n-acetylmuramyl-l-alanyl-d-isoglutamine (mdp) or lipopolysaccharide when compared with macrophages from normoresponsive c57bl/6j mice. liposomes containing a lipophilic muramyl dipeptide mdp-glyceroyl dipalmitate, macrophage activating factor or gamma-interferon restored tumori ...	1988	3360595
neutrophil involvement in effects of diethylstilbestrol and strontium 89 on macrophage activation by propionibacterium acnes.	we have recently demonstrated that diethylstilbestrol (des) significantly suppresses macrophage (m phi) activation by propionibacterium acnes. because the initial activation of m phi by p. acnes appears to involve the close interaction of the killed bacteria with inflammatory neutrophils (pmn) and resident m phi in the peritoneal cavity, we investigated whether the des inhibition of m phi activation was associated with inhibition of the pmn response. our data demonstrate that treatment of mice w ...	1988	3366512
susceptibility of anaerobic bacteria to antimicrobial agents.	the antimicrobial susceptibility of 1,117 clinical isolates of anaerobic bacteria was determined by the agar dilution technique. metronidazole was the most active agent; only propionibacterium acnes and actinomyces sp. isolates were resistant. clindamycin and chloramphenical were the next most effective agents. beta-lactam antibiotics, with the exception of penicillin, were active against most anaerobes other than the bacteroides fragilis group. at a breakpoint of 8 mg/l, 25% of fusobacterium sp ...	1988	3374973
liver injury model in mice for immunopharmacological study.	experimental liver injury was produced in mice by the immunological technique. the utility of these models as an immunopharmacological method was investigated. the first model was produced by the injection of anti-basic liver protein (blp) rabbit antibody into dba/2 mice that had been previously immunized with rabbit igg. the second liver injury was caused by injection of anti-liver specific protein (lsp) rabbit antibody into dba/2 mice. the third model was produced by the injection of bacterial ...	1988	3379835
the ability of inflammatory bronchoalveolar leucocyte populations elicited with microbes or mineral dust to injure alveolar epithelial cells and degrade extracellular matrix in vitro.	inflammatory cells are recruited to the parenchyma of the lung in a range of conditions where they are considered to have the ability to exert damaging effects on elements of the alveolus. the injurious effects of rat bronchoalveolar-derived inflammatory cells on an alveolar type ii epithelial cell line were therefore assessed. inflammatory populations produced by intratracheal injection of corynebacterium parvum or quartz caused non-lethal detachment injury to the epithelial cells on co-culture ...	1988	3390385
amnionitis caused by propionibacterium acnes. case report.		1988	3390407
the incidence of bacteremia in skin surgery of the head and neck.	the normal microflora of skin vary significantly between sebaceous rich, wet, and dry areas. this would be expected to influence the likelihood of developing transient bacteremia while undergoing skin surgery on these different areas, thereby affecting the risk of infective endocarditis from such procedures. we evaluated the incidence of transient bacteremia in 45 patients undergoing skin surgery on the sebaceous rich areas of the head and neck. after surveillance skin cultures, aerobic and anae ...	1988	3403731
[propionibacterium acnes endocarditis on a natural valve].		1988	3406481
phagocytic and natural killer cytotoxic responses of murine transitional cell carcinoma to postsurgical immunochemotherapy.	postsurgical immunochemotherapy with corynebacterium parvum (cp) and cis-diamminedichloroplatinum (ii) (cddp) was evaluated in mice with transitional cell carcinoma (mbt-2). c3h/he mice were transplanted subcutaneously in the hind limb with 5 x 10(5) tumor cells. ten to 14 days later when the tumor reached a diameter of five to seven mm., it was surgically removed. mice were then randomized into four groups to receive a total of three treatments on days 1, 3 and 5 after surgery: 1) saline (contr ...	1988	3411696
propionibacterium acnes in purulent arthritis: probable cause of iatrogenic infection.		1988	3418633
modulation of major histocompatibility complex (mhc) expression by interferons and microbial agents. independent regulation of mhc class ii expression and induction of tumoricidal activity in bone marrow-derived mononuclear phagocytes.	in a pure population of rat bone marrow-derived mononuclear phagocytes (bmm phi), the expression of major histocompatibility complex (mhc) molecules and ability to manifest tumoricidal activity were simultaneously studied. resting bmm phi, which express low levels of mhc class ii molecules and do not manifest tumoricidal activity, become strongly mhc class ii-positive, and evolve tumoricidal activity within 24 h when incubated with macrophage-activating lymphokines (maf) or gamma interferon (ifn ...	1988	2456605
the use of non-specific immunopotentiators in experimental trypanosoma cruzi infection.	the effects of levamisole, isoprinosine and corynebacterium parvum on trypanosoma cruzi (y strain) experimental infection of mice were studied. in prophylactic treatment these drugs reduced the peak of parasitaemia, and had no apparent effect on mortality rate or on histopathological and electrocardiographic findings. levamisole and isoprinosine had no effect when used after infection. electrocardiograms were obtained from all chronic chagasic mice. the most frequent changes were left atrial ove ...	1988	2459820
[pleurodesis as a palliative method in the treatment of pleural effusions of malignant etiology].		1988	2460882
[interferon production and natural killer activity of peripheral blood lymphocytes obtained from patients with multiple sclerosis].	interferon (ifn) -system of patients with multiple sclerosis (ms) during the stable stage of the disease activity was investigated. thirty six patients were divided into 3 groups of mild, moderate and severe patients according to the scores of disability status scale (dss). ifn-alpha producibility and natural killer (nk) activity of peripheral blood lymphocytes (pbl) or large granular lymphocytes (lgl) fractionated from pbl were determined by culturing with hela cells persistently infected with ...	1988	2464533
enhancement of nonspecific resistance to viral infection by chemically synthesized lipid a-subunit analogs with different backbone structures and acyl groups.	protection against vaccinia virus infection and induction of interferon (ifn) were investigated in propionibacterium acnes-primed mice following treatment with chemically synthesized lipid a-subunit derivatives. the antiviral activity was based on the reduction of numbers of tail lesions in mice injected intravenously with the test compounds 1 day before virus infection. gla-27, a 4-o-phosphono-d-glucosamine carrying 3-o-tetradecanoyl (c14) and n-3-tetradecanoyloxytetradecanoyl [c14-o-(c14)] gro ...	1988	2465734
a randomized trial of intracavitary bleomycin and corynebacterium parvum in the control of malignant pleural effusions.	fifty-eight patients with malignant pleural effusions were entered into a prospectively randomized clinical trial comparing the efficacy of a local instillation of bleomycin or corynebacterium parvum (c. parvum) in controlling fluid reaccumulation after simple needle aspiration (thoracentesis). the response was assessed at 30 days by chest x-ray and clinical examination. there were 44 evaluable patients; 18 of 25 (72%) of those receiving bleomycin and 9/19 (47%) of those who had c. parvum gained ...	1989	2467327
intracavitary therapy with bleomycin for the treatment of malignant pleural effusions.	this paper briefly reviews the incidence of malignant pleural effusions (mpe) and the measures that have been used to treat this condition. the role of intracavitary bleomycin in controlling mpe, the doses used, and morbidity associated with its use are reviewed in depth with reference to multicenter studies that the author has coordinated as well as the published literature. the short- and long-term results reported when bleomycin was used alone or as compared with other agents are discussed. t ...	1989	2475118
comparison of corynebacterium parvum and bordetella pertussis with freund's complete adjuvant as immunopotentiators for beta-human chorionic gonadotropin linked to an atoxic fragment of tetanus toxin.	corynebacterium parvum and bordetella pertussis were compared with freund's complete adjuvant (fca) for their abilities to potentiate the immune response to haptenic beta-human chorionic gonadotropin covalently coupled to an atoxic 54,000-molecular-weight fragment of tetanus toxin (beta-hcg-ttii). the ability of each adjuvant to enhance production of antibodies to hcg in rabbits was measured by 125i-hcg radioimmunoassay. at sera dilutions of 1:10,000, analysis of variance for the 8-week postimmu ...	1989	2475138
analysis of propionibacterium acnes-induced non-specific immunity to trypanosoma brucei in mice.	mice treated with dead propionibacterium acnes (previously called corynebacterium parvum), up to 30 days before infection with any of three strains of trypanosoma brucei, were more able to limit the level of first-wave parasitaemia than untreated controls. reduced parasitaemia was not due to enhanced phagocytosis of input parasites and was associated with a dramatic reduction in the proportion of multiplying t. brucei in the blood of treated as compared to control mice. for 4 days after p. acnes ...	1989	2476711
characterization of interferons produced by peripheral blood mononuclear cells from healthy subjects in response to corynebacterium parvum or poly i: poly c.	the biological significance of acid labile interferon alpha is presently unknown. we examined the putative production of acid labile interferon in vitro from human peripheral blood mononuclear cells induced with corynebacterium parvum or poly i: poly c. both agents induced up to 1200 iu/ml interferon, and the interferon was 80 to 90% acid labile. the interferons were typed by antibody neutralization of their antiviral activity. contrary to previous reports, c. parvum induced predominantly interf ...	1989	2483976
modulation of macrophage functions by corynebacterium parvum preparations.	corynebacterium parvum has been used as an anti-tumor agent in both animal experiments and clinical trials; nevertheless it is not well established the mechanism of action, since both t-dependent and t-independent ways of action have been proposed. on the other hand, mononuclear phagocytic system activation cannot be ruled out in the immunomodulation carried out by c. parvum. in the attempt to better understand the effects of c. parvum on macrophage functions, experiments were carried out on tum ...	1989	2491287
protective effect of sk&f 86002, a novel dual inhibitor of arachidonic acid metabolism, in murine models of endotoxin shock: inhibition of tumor necrosis factor as a possible mechanism of action.	the effect of a new, structurally novel, dual inhibitor of arachidonic acid (aa) metabolism, sk&f 86002, was studied in two murine models of endotoxin shock. the first model was the injection of c57bl/6 mice with lipopolysaccharide (lps) in combination with d-galactosamine (d-gal), which resulted in death within 6-48 hr. treatment of these mice with sk&f 86002 (100 mg/kg, p.o.) 30 min to 2 hr prior to the administration of d-gal and lps protected the animals from mortality. protection was also p ...	1989	2492908
epithelial dendritic cells and connective tissue macrophages in oral carcinogenesis and the effects of systemic corynebacterium parvum.	epithelial dendritic cells (edc) and connective tissue macrophages were examined during the induction and growth of oral squamous cell carcinomas in sprague-dawley rats treated with the carcinogen 4-nitroquinoline n-oxide (4nqo) and the immune potentiator corynebacterium parvum. splenomegaly was induced in all animals receiving c. parvum. acetone-fixed frozen sections of the palate and tongue were stained using an indirect immunoperoxidase technique and monoclonal antibodies to rat ia (mrc ox-6) ...	1989	2493998
contamination of k-sol corneal storage medium with propionibacterium acnes.	k-sol is a widely used corneal preservation medium. it has an excellent record for corneal storage and no previous report of contamination. during september 1988, on five of our k-sol-stored donor rims propionibacterium acnes grew. cultures of unopened k-sol also yielded p acnes. this report reviews previous contaminations of corneal storage media and the special characteristics of p acnes that enabled it to survive precautions taken against infection. the detection of p acnes was not obvious, a ...	1989	2502104
corneal ulcers associated with disposable hydrogel contact lenses.	four patients developed corneal ulcers associated with the use of disposable extended-wear hydrogel contact lenses. bacteria were recovered from corneal ulcers in three of the patients. three patients discarded their contact lenses after ten or more days of extended wear; the corneal ulcers in these patients developed toward the end of the wearing cycle. the fourth patient removed her contact lenses every two days for cleaning and disinfection and discarded them for a new pair on a weekly basis. ...	1989	2502923