Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| inhibition of lymphocyte proliferation and antibody production in vitro by silica, talc, bentonite or corynebacterium parvum: involvement of peroxidative processes. | this study was undertaken to determine whether and by what means particles which induce granulomata in vivo can affect murine spleen lymphoproliferative and antibody responses in vitro. particles of silica, talc, bentonite or c. parvum cells inhibited lipopolysaccharide- or concanavalin a-stimulated proliferation and sheep red blood cell-induced antibody response in vitro. the inhibition required at least 48 hours exposure of the cells to the particles. the late onset of inhibition and its repro ... | 1983 | 6303797 |
| adherence of streptococci to cells infected with herpesvirus. | the attachment of streptococci and staphylococci to cells infected with influenza virus has been previously reported and has been correlated with the increased incidence of these bacterial infections during flu epidemics. the present work was initiated to determine whether infection with herpes simplex virus (hsv) might lead to preferential bacterial attachment. hep-2 cells were grown in monolayer and infected with hsv, type i or type ii. twenty-four hours later the cells were incubated with sus ... | 1983 | 6306535 |
| effects of ph on biomass, maximum specific growth rate and extracellular enzyme production by three species of cutaneous propionibacteria grown in continuous culture. | three cutaneous propionibacteria, propionibacterium acnes, propionibacterium avidum and propionibacterium granulosum, were grown in chemostats using semi-synthetic medium at various ph values. growth occurred between ph 4.5 and 7.5 for p. acnes and ph 5.0 and 8.0 for p. avidum and p. granulosum. the highest mumax was at ph 6.0 for the three species. maximum biomass production was obtained at ph 6.0 for p. acnes and p. avidum and at ph 7.5 for p. granulosum. extracellular enzyme production occurr ... | 1983 | 6311940 |
| propionibacteria in patients with acne vulgaris and in healthy persons. | a total of 375 anaerobic and microaerophilic coryneform rods, isolated from the pilosebaceous ducts of 26 healthy persons (71 strains) and from comedones (93 strains), pustules (107 strains), and the unaffected skin (104 strains) of 36 acne patients were classified according to the species key in bergey's manual, the biotyping scheme of pulverer and ko, the serotyping schedule of höffer et al., and the phage typing schedule of jong et al. the statistical evaluation demonstrated certain differenc ... | 1983 | 6223602 |
| teichomycin: in-vitro and in-vivo evaluation in comparison with other antibiotics. | teichomycin, a new glycopeptide antibiotic with a spectrum of activity similar to that of vancomycin, was highly active against staphylococci, streptococci and gram-positive anaerobes (propionibacterium acnes, clostridium perfringens and cl. difficile). ninety per cent of the staphylococcus aureus and streptococcal strains, including enterococci, were inhibited by 0.4 mg/l; 90% of staph. epidermidis strains were susceptible to 1.6 mg/l. vancomycin was less active than teichomycin against all cli ... | 1983 | 6223907 |
| resistance of propionibacteria to antibiotics used in the treatment of acne. | strains of propionibacteria resistant to clindamycin or clindamycin and erythromycin were isolated from four patients with acne, three of whom were receiving clindamycin. four strains of p. acnes and one of p. granulosum with moderate levels of tetracycline resistance were isolated from 25 patients with acne being treated with tetracycline. a similar increase in tetracycline resistance was achieved by training sensitive strains in vitro. p. acnes was sensitive to sulphonamide and trimethoprim bu ... | 1983 | 6224016 |
| what causes acne? | 1983 | 6224128 | |
| [acne: pathogenesis and therapy]. | 1983 | 6225028 | |
| mite fauna, housedust, and kawasaki disease. | 1983 | 6134934 | |
| variant strain of propionibacterium acnes: a clue to the aetiology of kawasaki disease. | by means of anaerobic culture for 3-4 weeks a variant strain of propionibacterium acnes was isolated from one lymph-node biopsy specimen, and from blood samples of five of twenty-three patients with early kawasaki disease, but from only one of fifteen blood samples from patients after 8 days' illness. no anaerobe was isolated from sixty age-matched controls with various disorders, but the same bacillus with the same serotype was isolated from house-dust mites from six patients' homes. patients h ... | 1983 | 6140493 |
| aerobic and anaerobic bacteriologic features of serous otitis media in children. | aspirates of serous ear fluids from 57 children were examined for aerobic and anaerobic bacteria. bacterial growth was noted in 23 patients (40 per cent). aerobic organisms only were recovered in 13 aspirates (57 per cent of the culture-positive aspirates); anaerobic bacteria in four (17 per cent); and mixed aerobic and anaerobic bacteria in six (26 per cent). a total of 45 bacterial isolates were recovered, accounting for 2.0 isolates per specimen (1.4 aerobes and 0.6 anaerobe). there were a to ... | 1983 | 6140881 |
| [anaerobic sepsis]. | 1983 | 6141318 | |
| protection by polyi:polyc against infection with herpes simplex virus in mice pretreated with corynebacterium parvum. | the effect of corynebacterium parvum on the protection by polyinosinic-polycytidylic acid (polyi:polyc) against lethal infection with herpes simplex virus type 1 (hsv) was studied in mice. pretreatment with c. parvum resulted in prolonged survival times in all experiments. one third of the mice survived an infection with 100 ld50, whereas all mice died when treated with polyi:polyc alone. increased protection was observed up to 6 weeks after pretreatment and only seen when both c. parvum and pol ... | 1983 | 6209572 |
| immunotherapy in genitourinary neoplasia. | the putative role of the immune response in the natural defense against neoplasia remains poorly defined. correspondingly, its potential recruitment as a means of cancer therapy has remained unfulfilled. the intricate interactions of immune response mechanisms as well as the heterogeneity of tumor cells themselves have contributed to this situation. moreover, the immunosenescence that occurs during aging may have further compromised potential means of recruiting immune response mechanisms in tre ... | 1984 | 6209844 |
| antitumor therapy based on the use of an immune modulator, arginine butyrate and interferon. | the analysis of the likely physiological role of interferon during pregnancy and antitumor protection can be employed in developing a new strategy in antitumor therapy. indeed, pretreatment of the patients with a potent immune stimulation compensates to some extent interferon's immune repressive effects. through the modulation of the cytoskeleton, interferon enhances macrophage activity. moreover, butyrate by its own effect on the malignant phenotype increases interferon sensitivity in a number ... | 1984 | 6085812 |
| an improved macrophage spreading assay--a simple and effective measure of activation. | the development of a quantitative spreading assay of macrophage activation is described. the assay involved incubation of macrophages on glass coverslips for 1 hour and assessment of cell size using a microscope attached to a microcomputer-assisted digitising system which allowed the diameter of 200 cells to be assessed within 10 minutes. mouse peritoneal macrophages were used in the development of the assay. internal consistency of the assay was shown by minimal inter-observer, intra-observer a ... | 1984 | 6086500 |
| antimicrobial susceptibility of anaerobic bacteria in sweden in 1983. | this review is concerned with anaerobic bacteria and antimicrobial susceptibility. data on the susceptibility to different antimicrobials of anaerobic isolates in sweden during 1983 is presented. among the different bacterial groups, clostridium perfringens, propionibacteria, anaerobic cocci and curved rods were found to be susceptible to beta-lactam antibiotics, clindamycin and chloramphenicol. c. difficile was susceptible to benzylpenicillin and imipenem, but resistant to cefoxitin. most c. di ... | 1984 | 6100139 |
| synergistic effect between neutrophils and corynebacterium parvum in the process of macrophage activation. | adoptive transfer of granulocytes exposed to corynebacterium parvum in vivo or in vitro efficiently activates murine peritoneal macrophages in vivo. a comparison of the amount of bacteria required to produce similar levels of cytolytic activity indicated that 2 x 10(7) intracellular (neutrophil) bacteria were as efficient as 1 x 10(10) bacteria introduced directly. the time courses of macrophage cytotoxicity induced by these two methods were found comparable. similar levels of activity were also ... | 1984 | 6228293 |
| an immunological mechanism for the reduced incidence of malignant melanoma in patients with acne? | 1984 | 6229266 | |
| skin microbiology: coming of age. | 1984 | 6229637 | |
| effects of sub-lethal concentrations of the antimicrobial agent propylene phenoxetol on the growth and extracellular enzymes of propionibacterium acnes. | propionibacterium acnes was grown in continuous culture in the presence of propylene phenoxetol. at sub-lethal concentrations of this antimicrobial agent (0.025-0.1% w/v) steady-state growth conditions were achieved. in comparison with the control, cell biomass, maximum specific growth rates and levels of the extracellular lipase and hyaluronate-lyase, decreased with increasing concentrations of propylene phenoxetol. levels of protease activity remained approximately constant whilst production o ... | 1984 | 6231455 |
| the mode of action of ethyl lactate as a treatment for acne. | we have shown that an alcoholic lotion containing ethyl lactate when applied topically to rat skin under occlusion became localized in the follicles and sebaceous glands. when applied to human facial skin the ethyl lactate was hydrolysed to ethanol and lactic acid, and thereby lowered the skin ph. under such conditions the growth of recoverable skin bacteria, in particular the anaerobe propionibacterium acnes, was inhibited, and the hydrolysis of sebum to free fatty acids by lipase derived from ... | 1984 | 6231941 |
| effects of corynebacterium parvum after intraperitoneal injection in hamsters. | 1984 | 6233193 | |
| bacteriology and acne. | 1984 | 6233232 | |
| acne treatment with topical erythromycin and zinc: effect of propionibacterium acnes and free fatty acid composition. | a double-blind investigation has been conducted to examine the effect of topical 4% erythromycin/1.2% zinc acetate solution and its vehicle on quantitative bacterial counts (skin surface washings) of propionibacterium acnes and the free fatty acids of the skin surface. the logarithmic counts for p. acnes in the erythromycin/zinc group showed a significant reduction (98%) following 10 weeks of therapy. this compared with a 43% change shown for the vehicle-control group. a significant reduction (6 ... | 1984 | 6234335 |
| the microbial ecology of pilosebaceous units isolated from human skin. | a method allowing isolation and microbiological analysis of individual pilosebaceous units (follicles) was used to study biopsies of back skin obtained from volunteer acne vulgaris patients. the main microbial groups isolated were members of the genera propionibacterium, staphylococcus and pityrosporum. the incidence (and mean density) of these organisms in 140 normal follicles was 12% (2.6 x 10(5) per follicle), 4% (5.5 x 10(3) per follicle) and 13% (10(2) per follicle) respectively. colonized ... | 1984 | 6234376 |
| paradoxical presence of t cell anergy during successful t cell-dependent tumour immunotherapy: characterization of a state of t cell 'amnaesia' following systemic administration of c. parvum. | systemic administration of corynebacterium parvum causes t cell-dependent regression of an established methylcholanthrene-induced murine fibrosarcoma beginning 10 days after cp injection. at this time, tumour specific effector t cell responses measured by reactivity in a t helper cell assay or in a winn assay disappear only to return later. we refer to this temporary lapse in t cell reactivity as immunological 'amnaesia'. antigen specific t cell responses within all lymphoid organs appear to be ... | 1984 | 6235074 |
| moderate to high dose cyclophosphamide and intercalated corynebacterium parvum in patients with metastatic lung cancer. | thirty-nine patients with histologically proven widely metastatic bronchogenic carcinoma were treated with cyclophosphamide and corynebacterium parvum. the dosage of cyclophosphamide was higher than conventional as previous work had indicated better results with increased dosage. experimental work had suggested that the addition of corynebacterium parvum would increase the antitumour effect and possibly reduce the cyclophosphamide induced granulocytopenia. a short treatment programme using three ... | 1984 | 6318791 |
| antitumor immunity induced by hybrid tumor cells: comparison between hybrids and the parental tumor. | the ability of hybrid tumor cells to induce antitumor immunity has been evaluated in the line 1 alveolar cell carcinoma (l1) model of balb/c mice. hybrid tumor cells were produced by fusing freshly dissociated l1 cells isolated from in vivo tumors with the hypoxanthine:aminopterin:thymidine-sensitive cell line, gm 347, derived from c3h mice. each hybrid was characterized by dna content and expression of h-2 antigens using a fluorescence-activated cell sorter. irradiated l1 cells in the presence ... | 1984 | 6318971 |
| chemiluminescence of asbestos-activated macrophages. | chemiluminescence, a measure of reactive oxygen release by phagocytes, was compared in peritoneal exudate macrophages elicited with chrysotile asbestos, corynebacterium parvum and saline. chrysotile asbestos- and c. parvum-activated macrophages produced significantly more chemiluminescence than saline-elicited macrophages. in a second series of experiments the ability of opsonized chrysotile asbestos to act as a trigger for the release of chemiluminescence was tested. opsonized chrysotile asbest ... | 1984 | 6320857 |
| protection of mice against infection with mouse hepatitis virus type 3 by injection of silica. | injection of silica did not brake the resistance against mhv3 conferred to c57bl/6 mice by injection of c. parvum. however, silica itself had a marked protective effect against mhv3 infection that was maximal when injecting 1 mg 2 hrs before virus infection. the protective effect of silica was observed in a number of inbred mouse strains that differ in their relative resistance to mhv3 infection. no viral titers were observed in the spleen and liver of mice which had received mhv3 plus silica, w ... | 1984 | 6325328 |
| expression of the transferrin receptor in murine peritoneal macrophages is modulated in the different stages of activation. | a specific high affinity binding site for the serum glycoprotein transferrin was identified on murine peritoneal macrophages. the binding reached equilibrium within 60 min and was reversible, saturable, and specific for transferrin. although the presence of this receptor was detected on the cell surface by studies carried out using intact cells, the majority (70 to 90%) of the binding activity was detectable only in detergent extracts of such cells. this suggests that a substantial portion of th ... | 1984 | 6325536 |
| [studies on the pathogenesis of non-spore-forming anaerobic bacteria in ocular infections. report 1. experimental endophthalmitis with propionibacterium acnes in guinea pigs and transition of viable cells in the vitreous body]. | 1984 | 6331719 | |
| t-cell recruitment regulated by prostaglandin-mediated system and its role in immune response. | the dynamics of the number of t cells in spleen and the level of prostaglandin e2 in plasma were investigated serially in mice injected with corynebacterium parvum. in the first few days, the level of plasma pge2 increased but decreased to lower than the normal level thereafter. the absolute number of t cells in the spleen began to increase after the pge2 level dropped. but such an increase of t cells was not observed in atx mice challenged with c. parvum. moreover, replenishing the mice with ex ... | 1984 | 6332775 |
| normal cultivable microflora in upper jejunal fluid in children without gastrointestinal disorders. | bacteriological studies of uncontaminated upper jejunal fluid were performed in 51 danish children without gastrointestinal disorders. thirty-seven percent of the samples were sterile [less than 10(1) colony-forming units (cfu)/ml]. in 25% of the cases, the total number of microorganisms exceeded 10(5) cfu/ml. the microorganisms isolated most frequently were: streptococcus, sp. ("viridans group"), veillonella parvula, hemophilus parainfluenzae, lactobacillus, sp., corynebacterium, sp., actinomyc ... | 1984 | 6334151 |
| thymus-recruited peritoneal exudate t lymphocytes. | the role of the thymus in the generation of antigen-reactive peritoneal exudate t lymphocytes (petls) was examined in mice injected with corynebacterium parvum (c. parvum), which exerted functions as a trigger of t cell recruitment from the thymus and as an antigen to induce antigen-reactive t cells. the proliferative response of antigen-reactive petls was higher in sham mice than in adult-thymectomized (atx) mice 3 weeks after injection of c. parvum. when indomethacin (indo) was injected simult ... | 1984 | 6335487 |
| immunostimulation: synthetic and biological modulators of immunity. | 1984 | 6203479 | |
| aerobic and anaerobic bacteria in neurosurgical infections. per-operative culture with flexible contact agar film. | fourteen of 80 patients (17.5 per cent) who underwent elective craniotomy preceded by a strict pre-operative routine of skin decontamination contracted postoperative wound infection. most of the infections were probably from endogenous sources and from eight of the wounds low-virulent resident skin bacteria, propionibacterium acnes and/or staphylococcus epidermidis, were isolated. since thorough pre-operative preparation of the skin did not reduce the incidence of infection to an acceptable leve ... | 1984 | 6205054 |
| antiviral effects of corynebacterium parvum and its effect on the interferon system in mice. | 1984 | 6206840 | |
| immunologic approaches to the management of ovarian carcinoma. | 1984 | 6207593 | |
| differences in tumour necrosis factor productive ability among rodents. | large differences in tumour necrosis factor (tnf) productive ability 05337257erved among various strains of mice. ddy, cd-1, icr and dba/2 mice could produce a high titre of tnf activity, whereas balb/c, c3h/hejms and a/j mice produced a low titre of tnf activity. administration of 200 micrograms/mouse of lps to some strains of mice, i.e. ddd and c57b1/6j resulted in good production of tnf. icr nu/nu mice produced the highest tnf activity among the nude mice. balb/c nu/nu and ddd nu/nu mice exhi ... | 1984 | 6386027 |
| immunosuppressive activities of peritoneal and splenic macrophages in murine leprosy: effect on lymphocyte transformation and tumor growth. | the ability of peritoneal macrophages (pm) and splenic macrophages (sm) to suppress tumor growth and lymphocyte transformation in vitro was studied in infected mice with mycobacterium lepraemurium (mlm). both pm and sm of leprous mice showed cytostatic activity against tumor cells in vitro. however, such cells showed significantly less cytostatic activity on a per cell basis than highly activated macrophages obtained from corynebacterium parvum-immunized mice. furthermore, this cytostatic activi ... | 1984 | 6387401 |
| isolation of obligate anaerobic bacteria from bovine abscesses in sites other than the liver. | a survey in japan showed that of 2036 slaughtered cattle 58(3%) had abscesses in sites other than the liver. in 21 of the affected animals the lesions were pulmonary and in 32 abdominal (excluding hepatic); in five animals the lesions were found elsewhere (muscle 2, skin 2, bone 1). nineteen (33%) of the 58 cattle also had abscesses in the liver. obligate anaerobes alone were isolated from 17(29%) of the affected animals (fusobacterium necrophorum 14, bacteroides spp. 2, peptostreptococcus anaer ... | 1984 | 6389873 |
| treatment of inoperable non-small cell carcinoma of the lung with radiation therapy, with or without levamisole. a randomized trial of the southeastern cancer study group. | in a randomized trial, 251 patients with inoperable non-small cell lung cancer received radiation therapy (rt) with or without levamisole (2.5 mg/kg twice weekly for 1 year, or until progression). radiation therapy was delivered to 6000-6500 rad for stages i and ii, and 4000-4500 rad by continuous or split course for stage iii disease. responses were observed in 40% of patients receiving placebo, and in 29% of patients taking levamisole. relapse occurred at local sites only in 53% of the placebo ... | 1984 | 6391141 |
| role of first stimulating agents in the production of tumor necrosis factor. | the conditions and kinetics of tumor necrosis factor (tnf) production were examined. for tnf production, dual stimulation is necessary. priming agents such as bcg, corynebacterium parvum, and zymosan, which can stimulate the reticuloendothelial system (res), are good substances for tnf production with the aid of lipopolysaccharide. wide differences are observed in tnf producibility among different priming agents. the producibility of tnf depends on the degree of stimulation of the res by the pri ... | 1984 | 6391657 |
| [clinical trials of immunotherapy in lung cancer]. | 1984 | 6393588 | |
| [corynebacteria--stimulators of antitumor resistance]. | the results of clinical and experimental studies with corynebacteria stimulation of antitumour resistance are described. it is shown that antitumour effect depends on the mode, dose and period of corynebacteria administration as well as on the stage of the tumour process. the mode of corynebacteria action is under discussion. there are doubts as to expediency of such a method of nonspecific immunotherapy of malignant tumours. | 1984 | 6396064 |
| radiosensitivity of c. parvum-stimulated spleen to acute 60co and low dose rate 137cs and 252cf irradiation. | stimulation of spleen growth by injection of c. parvum led to rapid organ enlargement, and acute 60co or low dose rate (ldr) 137cs or 252cf irradiation reduced the maximum enlargement achieved. irradiations were carried out 3 days after cp injection. sigmoid dose-response curves were observed for the fraction of maximum enlargement achieved after acute 60co. after low dose rate 137cs or 252cf irradiation, exponential dose-response curves of very different slope were observed. acute and ldr gamma ... | 1984 | 6396264 |
| propionibacterium, corynebacterium, mycobacterium and lepra bacilli. | evidence is presented which suggests that certain key markers of lepra bacilli reside collectively in proprionibacterium acnes, corynebacterium tuberculostearicum and mycobacterium leprae. the unrestricted replication of mycobacterium leprae depends most probably upon the presence of an immune-deficiency-inducing viral agent or possibly on the combined effects of the organisms considered. | 1984 | 6398580 |
| biological activity of pityrosporum. i. enhancement of resistance in mice stimulated by pityrosporum against salmonella typhimurium. | the effect of administration with pityrosporum (p. orbiculare, p. ovale, p. pachydermatis and pityrosporum sp.) on susceptibility of mice to salmonella typhimurium infection was studied. pretreatment of mice with 50 mg (wet weight) of killed pityrosporum 4 days prior to the intraperitoneal (i.p.) challenge of 4 x 10(5) (10 ld50) s. typhimurium elicited resistance comparable to that induced by 500 micrograms (dry weight) of killed propionibacterium acnes and over 30% of the infected mice survived ... | 1984 | 6368372 |
| combination chemotherapy (vac/fmc) with immunostimulation in metastatic breast cancer: a randomized study comparing different times and routes of administration of corynebacterium parvum. | from january 1978 to december 1980, 222 patients with metastatic breast cancer were included into a prospective multicenter trial. all patients were treated once a month with six cycles of vac- (vincristine, adriamycin, cyclophosphamide) chemotherapy, followed by fmc (5-fluorouracil, methotrexate, cyclophosphamide) until progression was documented. by random assignment, the patients received immunostimulation with corynebacterium parvum (cp) by one of four methods: subcutaneous (sc) on either da ... | 1984 | 6368960 |
| ineffectiveness of adjuvant chemotherapy using dtic and cyclophosphamide in patients with resectable metastatic melanoma. | a randomized, prospective trial of adjuvant chemoimmunotherapy was compared in a group of 136 patients with melanoma after complete surgical resection of advanced regional metastasis (stage iii) or isolated distant metastasis (stage iv). all patients received a 2-year course of nonspecific adjuvant immunotherapy of subcutaneous injections of corynebacterium parvum (4 mg/m2 divided among the four extremities in 1- to 2-week cycles). half of the patients also received a 6-month course of dimethyl ... | 1984 | 6369594 |
| controlled study with imidazole carboxamide (dtic), dtic + bacillus calmette-guérin (bcg), and dtic + corynebacterium parvum in advanced malignant melanoma. w.h.o. collaborating centres for evaluation of methods of diagnosis and treatment of melanoma. | from 1976 to 1980, 377 randomized patients were entered in a multicentric study supported by the w.h.o. melanoma group. in this report, only 196 patients are considered for analysis: 31.6% were excluded because of inadequate treatment or protocol violations. three arms of treatment were compared: dtic alone, dtic plus bacillus calmette-guérin, and dtic plus corynebacterium parvum. no significant difference in terms of complete response plus partial response was detected among the three regimens. ... | 1984 | 6369694 |
| bactericidal activity of wet cerumen. | the viable populations of seven species of bacteria were reduced 17% to 99% by treatment with a 3% suspension of human cerumen of the soft or "wet" type. species tested for susceptibility to cerumen were staphylococcus aureus, staphlylococcus epidermidis, streptococcus pyogenes, propionibacterium acnes, corynebacterium spp, escherichia coli, and serratia marcescens. the reduction depended upon the species of bacterium and the age of the culture. pathogenic species appeared to be more susceptible ... | 1984 | 6370076 |
| a longitudinal study of actinomyces israelii in the female genital tract. | a prospective longitudinal investigation was performed to study variations in the occurrence of actinomyces israelii with reference to four microorganisms, staphylococci, e. coli, p. acnes and c. albicans, in the female genital tract. fifteen healthy women were studied during all phases of the menstrual cycle. sampling was made from the cervix, vagina and perineal area three times a week during two consecutive menstrual periods and during menstruation from napkins and tampons. altogether 1108 sa ... | 1984 | 6375245 |
| [mechanisms of production of tumor necrosis factor (tnf)--reconstitution experiment white nude mice]. | in order to investigate the role of t cells in the production of tumor necrosis factor (tnf), a reconstitution experiment was performed with nude mice (balb/c, nu/nu). the results obtained were as follows: the cytotoxic activity of tumor necrosis serum (tns) from balb/c, nu/nu mice treated with p. acnes-lps was 1/22 against that from balb/c, nu/+ mice. tnf activity increased 14 times in reconstituted nude mice against balb/c, nu/nu mice. investigation of the production of the cytotoxic activity ... | 1984 | 6375575 |
| [postoperative immunostimulation in non-small-cell bronchial carcinoma. outcome and complications]. | in two prospective, randomized clinical studies corynebacterium parvum (c.p.), bcg or 0.9% saline solution were injected intrapleurally once between the 6th and 12th postoperative day in 878 patients with resected, non-oatcell bronchial carcinoma (stage i and ii). the rate of complications following c.p.-instillation (chest pain, fever) was relatively low compared to partially serious complications following injection of bcg, especially in patients who underwent pneumonectomy (21.8% empyema comp ... | 1984 | 6376041 |
| frequent isolation of propionibacterium acnes from sarcoidosis lymph nodes. | isolation of propionibacterium acnes from biopsied lymph nodes of sarcoidosis patients and from the lymph nodes or other tissues of non-sarcoidosis patients was carried out, carefully avoiding contamination by skin-resident p. acnes. out of 40 sarcoidosis lymph nodes examined, 31 nodes (77.5%) showed a positive culture of p. acnes, while 38 of 180 (21.1%) non-sarcoidosis tissues revealed positive results, the difference being significant (p less than 0.001). among non-sarcoidosis tissues, the in ... | 1984 | 6377763 |
| immunomodulators in the treatment of peritonitis in burned and malnourished animals. | deficiencies in the immune system that lead to increased morbidity and mortality from infectious complications have been well documented in patients suffering from trauma, malnutrition, sepsis, and thermal injuries. we investigated the potential benefit of immune stimulation for preventing infection in such conditions in an animal model by evaluating three drugs: corynebacterium parvum, thymopentin (tp-5), and cp-46,665. one-hundred eighty female guinea pigs were rendered immunodeficient by firs ... | 1984 | 6379960 |
| intradermal injection of propionibacterium acnes: a model of inflammation relevant to acne. | the intradermal injection of 140 micrograms of propionibacterium acnes (cn 6134) into the ears of female sprague-dawley rats produced a chronic inflammation with formation of acneiform lesions. inflammation was characterized by more than a doubling of ear thickness at 24 h and a peak of 3-4 times control levels at day 21. at 42 days post injection ears were still 3 times normal thickness. histologically there was early polymorph accumulation giving way to macrophages and lymphocytes by day 7. pi ... | 1984 | 6238104 |
| antimicrobial properties of gentamicin on the skin. | 1984 | 6238917 | |
| acne. | 1984 | 6238981 | |
| [antagonistic properties of propionibacterium strains isolated from acne lesions]. | 1984 | 6239963 | |
| cell to cell interactions of capnocytophaga and bacteroides species with other oral bacteria and their potential role in development of plaque. | 1984 | 6241228 | |
| heterogeneity of macrophages and dendritic cells as accessory cells. | a number of different antigens was used to define the functional limits of ia-bearing murine dendritic cells and macrophages in the processing and presentation of antigens for t cell activation. the results show considerable functional overlap as well as differences attributable to known properties of the cells. thus both cell types could present soluble antigens up to the size of polymeric flagellin (m.w. in millions) about equally well. the nonphagocytic dendritic cells were most effective at ... | 1984 | 6241597 |
| [characteristics of propionibacterium strains isolated from patients with acne juvenilis and from healthy persons]. | 1984 | 6242063 | |
| difficulties in producing antibodies to purified propionibacterium acnes exocellular enzymes. | attempts were made to produce antisera to purified preparations of propionibacterium acnes lipase, hyaluronate lyase and acid phosphatase in rabbits. antiserum to lipase (neutralizing titre i:32) was produced using conventional methods. lipase (30 micrograms) in freund's complete adjuvant (fca) was injected into multiple sites thrice at weekly intervals. antibody levels were boosted by i.v. injections of 30 micrograms in saline at 2-weekly intervals for 2 months. such regimes failed to raise ant ... | 1984 | 6691919 |
| the bacterial flora of the forehead and back of alaskan native villagers in summer and in winter. | the bacterial flora of the forehead and back of eskimo and indian villagers in arctic alaska was determined in midsummer and in winter (temperature -29 degrees to -46 degrees c). specimens collected by the wet swab method were transported overnight, chilled, to seattle in buffered diluent with triton x-100. control tests showed good survival of principal skin organisms with moderate or large initial populations and a disproportionately greater loss with an initial sparse population. results of t ... | 1984 | 6699430 |
| variably acid-fast bacteria in a fatal case of hodgkin's disease. | 1984 | 6703743 | |
| immunotherapy with biochemically dissociated fractions of propionibacterium acnes in a murine ovarian cancer model. | the antitumor effect of two strains of propionibacterium acnes (pai and paii) and chemically derived fractions from the whole bacterial cell were studied using a murine ovarian teratocarcinoma (mot) model. when injected i.p. in high doses (700 to 1400 micrograms/mouse), both strains produce survival of a significant proportion of tumor-bearing mice (30 to 90%). on a weight to weight basis, however, pai was significantly more effective than paii. pai and paii were extracted using pyridine, which ... | 1984 | 6713388 |
| the adverse effect of pregnancy on macrophage activation. | recently a remarkable decrease in the resistance to infection with listeria monocytogenes and toxoplasma gondii in pregnant mice was demonstrated. since activated macrophages are important in the resistance against these organisms, studies were performed to determine whether pregnancy has an adverse effect on the activation of macrophages and effector functions of these macrophages. peritoneal macrophages from normal pregnant and virgin mice or from pregnant and virgin mice previously injected w ... | 1984 | 6713543 |
| effect of pregnancy on augmentation of natural killer cell activity by corynebacterium parvum and toxoplasma gondii. | studies were performed to determine the effect of pregnancy on nk cell activity and the augmentation of nk cell activity which normally follows injection of killed c. parvum or live t. gondii. when compared to cells from virgin mice, peritoneal and splenic cells from unstimulated pregnant mice showed no significant difference in nk activity. in contrast, nk activity of peritoneal cells from pregnant mice that received c. parvum or t. gondii was significantly lower than that found in comparably t ... | 1984 | 6715884 |
| enhancement of thermal response of normal and malignant tissues by corynebacterium parvum. | further studies were carried out on the combined effects of corynebacterium parvum and hyperthermia on animal tissues and cultured chinese hamster ovary cells. experimental animals were c3hf/sed mice derived from our defined flora mouse colony. tumors were eighth-generation isotransplants of a spontaneous fibrosarcoma, fsa-ii. hyperthermia was given by immersing the mouse foot or culture flasks in the constant temperature water bath. present experiments include thermal enhancement of c. parvum a ... | 1984 | 6722772 |
| photoinactivation of propionibacterium acnes by near-ultraviolet light. | photodestruction of propionibacterium acnes was investigated by broad-band near-ultraviolet light. the inactivation of the bacteria was found to be oxygen dependent, and without o2 practically no photoinactivation occurred. d2o caused an increased inactivation (d10 = 5 kj/m2 in d2o as compared to d10 = 11 kj/m2 in normal water). decreased temperature during illumination increased the ability to form colonies. the results are compared with corresponding results for other types of cells and the de ... | 1984 | 6730638 |
| changes in the bacterial flora of the external ear canal from the wearing of occlusive equipment. | external otitis has been associated with wearing obstructive gear covering the earlobe and external ear canal. in this study we investigated the changes in the bacterial flora of the external ear canal after wearing rubber hoods. the bacterial flora of external ear canals surfaces was investigated in a group of 19 volunteers who wore rubber hoods for a period of 25 to 30 minutes while doing manual work. the protective effect of 2% acetic acid was tested by instilling it in the left ear of all pa ... | 1984 | 6738278 |
| comparative bacteriology of chronic blepharitis. | one hundred and fifteen patients with chronic blepharitis were compared with 47 normal controls. six clinically distinct groups of blepharitis were observed: staphylococcal; seborrhoeic, alone, with associated staphylococcal superinfection, meibomian seborrhoea, or secondary inflammation of the meibomian glands; and meibomian keratoconjunctivitis (mkc). staphylococcus aureus was isolated in appreciable frequency from the staphylococcal and the mixed staphylococcal/seborrhoeic groups in contrast ... | 1984 | 6743618 |
| acetic, propionic, and oleic acid as the possible factors influencing the predominant residence of some species of propionibacterium and coagulase-negative staphylococcus on normal human skin. | the minimum inhibitory concentration (mic) of acetic and propionic acid for resident bacteria on normal human skin, such as propionibacterium acnes and staphylococcus epidermidis, was 25 mg/ml or more at any ph tested (ph 5.5-6.8). while the mic of these acids for most of the transient bacteria was markedly decreased by lowering the ph of the media and at ph 5.5, the mean ph value of the normal human skin, the mic was 6.25 mg/ml or less. the mic of oleic acid for some strains of gram-positive tr ... | 1984 | 6744125 |
| oxygen radical production by peritoneal macrophages and kupffer cells elicited with lactobacillus casei. | balb/c mice were injected intraperitoneally (i.p.) or intravenously (i.v.) with lactobacillus casei yit9018 (lc 9018). the i.p. injected lc 9018 augmented oxygen radical (or) production by peritoneal macrophages (pm) and suppressed the production of prostaglandin e2 by pm. the growth of i.p. inoculated meth a fibrosarcoma was also inhibited by an i.p. injection of lc 9018. i.v. injection of lc 9018 stimulated or production by fixed macrophages and inhibited the growth of listeria monocytogenes i ... | 1984 | 6423544 |
| adoptive immunization against an established tumor with cytolytic versus memory t cells. immediate versus delayed onset of regression. | intradermal injection of an admixture of p815 tumor cells and corynebacterium parvum results in the emergence of a tumor that grows progressively for 9-10 days and then undergoes complete regression. tumor regression is preceded by a cytolytic t cell response in the spleen that peaks on day 10 and then undergoes progressive decay until days 15-16 when cytolytic t cells can no longer be detected. passive transfer of 10-day or 30-day spleen cells to t-cell-deficient recipients bearing a 4-day tumo ... | 1984 | 6427998 |
| adjuvant requirements for protective immunization of mice using a trypanosoma cruzi 90k cell surface glycoprotein. | a wide range of adjuvants including alhydrogel, saponin, corynebacterium parvum, ddab, pfizer cp-20,961, oil adjuvants and several mdp analogues have been compared for their adjuvant activity in protecting mice against lethal trypanosoma cruzi infection following immunization with a t. cruzi 90k cell surface glycoprotein. only saponin was found to be effective. promotion did not correlate with the ability to promote a particular ig isotype; however, saponin was unique in its ability to promote c ... | 1984 | 6429057 |
| [isolation of propionibacterium acnes and enterobacter cloacae from a case of infective endocarditis]. | 1984 | 6431026 | |
| diffuse sclerosing osteomyelitis of the mandible. | the medical care of patients with diffuse sclerosing osteomyelitis (dso) of the mandible has been unsatisfactory. the main reasons for this have been insufficient knowledge of the disease and its natural history, difficulties in establishing the correct diagnosis, and the unknown etiology. the clinical features and natural history of the disease were studied by means of repeated radiographic and scintigraphic recordings. the biopsy technique was improved by using a slowly rotating coarse trepan ... | 1984 | 6437998 |
| comparison of antitumor activity of lactobacillus casei with other bacterial immunopotentiators. | antitumor activity of lactobacillus casei yit 9018 (lc9018) was demonstrated by intralesional (i.l.) or intravenous (i.v.) administration into tumor-bearing mice which were inoculated with methylcholanthrene-induced fibrosarcoma (meth a) or kirsten murine sarcoma virus-transformed tumor (k234) cells. its activity was significantly superior to the activity of two other species of lactobacilli but was nearly the same as that of corynebacterium parvum or mycobacterium bovis bacille calmette-guérin ... | 1984 | 6438456 |
| [experimental studies on the treatment and prophylaxis of cancer by immunoactivators and interferon]. | 1984 | 6440934 | |
| phospholipase c of an oral strain of propionibacterium acnes purification and partial characterization. | phospholipase c of the oral propionibacterium acnes strain d 7 was purified from culture supernatants and partially characterized. the molecular weight was found to be 32.000 and the optimum ph was situated between 7.0 to 8.0. this nonhemolytic enzyme hydrolyzed relative intensively acidic glycerophospholipids and produced 1,2-diglyceride from phosphatidyl choline. | 1984 | 6464569 |
| adjuvant immunotherapy of n-[4(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced bladder tumors. | the prophylactic effect of maltose tetrapalmitate (mtp), a newly developed non specific immunoadjuvant in preventing or delaying bladder cancer induction by n-[4(5-nitro-2-furyl)-2-thiazolyl] formamide (fanft) or in reducing the growth rate of the induced tumor was compared to other well-known immunoadjuvants (bcg, c. parvum, levamisole and pyran copolymer). the evaluation of the prophylactic role of immunoadjuvants demonstrated that mtp, levamisole and c. parvum were the most effective in prolo ... | 1984 | 6465859 |
| effects of soluble mediators generated during growth of the landschütz ascites carcinoma on the chemotaxis of normal and corynebacterium parvum-stimulated peritoneal leucocytes. | the influence of ascites fluid on the chemokinetic and chemotactic responses of mouse peritoneal leucocytes was investigated using modified boyden chambers and the 'leading front' technique. the migration of normal cells towards endotoxin-activated mouse serum was significantly enhanced at high concentrations of fluid (40 and 20%) but was inhibited at lower concentrations (5 and 1%). by comparison, the chemotactic responsiveness of cells harvested 3 days after corynebacterium parvum (c. parvum) ... | 1984 | 6466553 |
| role of vasoactive amines in the antitumor activity of endotoxin. | to estimate a possible role of vasoamines in the antitumor action of endotoxin, effects of isoproterenol, serotonin and adrenaline on subcutaneously transplanted murine meth a sarcoma and the capacity of these agents to elicit antitumor factors were studied. macroscopically all agents induced tumor necrosis and a temporal tumor growth stop, but only endotoxin was capable of induction of complete tumor regression. histology showed that all agents induced hyperemia by 4 h and hemorrhagic necrosis ... | 1984 | 6469605 |
| role of inflammatory neutrophils in antitumor effects induced by intraperitoneal administration of corynebacterium parvum in mice. | we studied the role of inflammatory neutrophils in the antitumor effects that follow i.p. injection of corynebacterium parvum (1400 micrograms) into c3heb/fej mice challenged with the murine ovarian teratocarcinoma. peritoneal neutrophils, obtained from mice 6 hr after injection of c. parvum, exerted significant antitumor effects when injected admixed with murine ovarian terato-carcinoma cells into the peritoneal cavities of normal mice. treatment of recipient mice with whole-body irradiation or ... | 1984 | 6488171 |
| augmentation of organ-associated natural killer activity by biological response modifiers. isolation and characterization of large granular lymphocytes from the liver. | natural killer (nk) activity in the rat and human has been attributed to cells having the morphology of large granular lymphocytes (lgl). however, this association has been less clear in the mouse, largely because of difficulties in obtaining highly enriched populations of lgl from normal spleen and blood. we have previously observed that the administration of the biological response modifier (brm) maleic anhydride divinyl ether (mve-2) strongly augmented nk activity in lung and liver, and the a ... | 1984 | 6491601 |
| [influence of corynebacterium parvum, bcg, ok-432 and lactobacillus casei on the hepatic drug-metabolizing systems and on the oxygen radical production by fixed macrophages in liver of balb/c mouse]. | 1984 | 6491874 | |
| [antitumor activity of bacterial fractions and related synthetic compounds]. | we have purified the cell-wall skeletons (cws) of mycobacterium bovis bcg, nocardia rubra, propionibacterium acnes and listeria monocytogenes as the adjuvant-active principles of these bacterial cells. these cell-wall skeleton preparations were shown to have antitumor activities in experimental tumor systems. especially bcg-cws and n. rubra-cws were applied for the treatment of human cancer. the synthetic immunoadjuvants such as cord factor, mycoloyl and quinonyl derivatives of n-acetylmuramyldi ... | 1984 | 6508322 |
| bimodal effects of mve-2 on cytotoxic activity of natural killer cell and macrophage tumoricidal activities. | maleic anhydride divinyl ether of molecular weight 15,500 (mve-2) increased tumoricidal activity of nk cells and m phi in a dose-dependent manner with the peak response of both effector cells occurring 3 days following treatment. both effector cell responses were sustained for over 7 days following one injection. however, repeated injections with mve-2 led to a hyporesponsiveness of nk cells whereas m phi activity remained high. poly iclc, but not c. parvum, reconstituted nk cell activity in mic ... | 1984 | 6511143 |
| [studies on experimentally induced acute hepatic failure: the significance of adherent cell activation in the liver]. | 1984 | 6513114 | |
| the importance of parasite load in the killing of plasmodium vinckei in mice treated with corynebacterium parvum or alloxan monohydrate. | mice pre-treated with corynebacterium parvum and later challenged with plasmodium vinckei become infected but do not die whereas control mice do. when pre-treated mice were challenged with 1, 10, 1 x 10(2), 1 x 10(4), 1 x 10(5) or 1 x 10(6) parasites, the pre-patent periods correlated directly with the number of parasites injected, but the subsequent parasitaemias reached similar levels. this suggests that parasite killing, resulting from pre-treatment with c. parvum, is not triggered until the ... | 1984 | 6514377 |
| influence of ph on porphyrin production in propionibacterium acnes. | propionibacterium acnes was grown on eagle's medium for 4-15 days at ph 5.3-7.2 the porphyrin production was measured both by direct fluorometry and by high pressure liquid chromatography (hplc). the greatest concentration of porphyrins was produced at ph 6.1. protoporphyrin was the dominant porphyrin species present in the bacteria in all samples. the relative amount of coproporphyrin was greatest at ph 6.7 after 4 days of incubation. in human skin there are local variations in the ph; therefor ... | 1984 | 6517611 |
| the effect of the immunomodulator corynebacterium parvum on hemisplenectomized mice. | the immunomodulator corynebacterium parvum stimulates the reticuloendothelial system and causes splenic hypertrophy. the ability of c parvum to stimulate splenic regeneration in hemisplenectomized mice and decrease susceptibility to intranasal pneumococcal challenge was studied. mice were divided into two groups, control sham-operated (n = 48) and hemisplenectomized (n = 47) animals. ten days later, each group was divided into two subgroups, those injected with c parvum (700 mcg ivp) and those i ... | 1984 | 6520680 |
| effect of some immunomodulators on the delayed-type hypersensitivity to nonviable mycoplasma pulmonis in mice. | 1984 | 6521151 | |
| an electrophoretic analysis of superoxide dismutase in campylobacter spp. | superoxide dismutase (sod, superoxide:superoxide reductase, ec 1.15.1.1) activity was studied in 23 strains of campylobacter spp. using disc polyacrylamide gel electrophoresis. different enzyme patterns were observed with extracts of different species of campylobacter; three migration bands were found in all strains of c. sputorum subsp. sputorum and c. sputorum subsp. bubulus (relative mobilities, rm, 0.57, 0.76 and 0.85), and c. fetus subsp. fetus (rm 0.60, 0.72 and 0.81), while four migration ... | 1984 | 6527124 |
| fatty acid composition of a propionibacterium acnes vaccine and its relationship to immunostimulatory activity. | the distribution of lipids of propionibacterium acnes (corynebacterium parvum) vaccine strain in chloroform-methanol, ethanol and light petroleum extracts was determined. firmly bound lipids released by hydrolysis were also investigated. the petroleum extract differs from other lipidic fractions in its fatty acid composition. the presence of linolic, tuberculostearic and 10-ketostearic acids and branched fatty alcohols was observed in addition to previously described fatty acids of p. acnes. cha ... | 1984 | 6532023 |