Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| effects of corynebacterium parvum vaccine in conjunction with immunosuppression in renal transplant in dogs. | 1982 | 7039044 | |
| a trial of nonspecific immunotherapy using systemic c. parvum in treated patients with dukes b and c colorectal cancer. | in view of the relatively poor prognosis for patients after surgery for locally invasive colorectal cancer a trial of repeated systemic infusions of corynebacterium parvum (cp) has been carried out. it is in this group of patients, with a high risk of recurrence from small residues of cancer left by the surgeon, that immunotherapy should have its optimum chance of success. a total of 92 patients were included in a randomized controlled study. the two groups were comparable in terms of tumour sta ... | 1982 | 7041943 |
| actinomycin-d plus 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamine (dtic) with or without intravenous corynebacterium parvum in metastatic malignant melanoma. | chemotherapy and chemoimmunotherapy of stage iv b malignant melanoma were compared in 88 patients. chemotherapy consisted of dtic 250 mg/m2 of the body surface area daily x five days and actinomycin-d 2 mg/m2 on day 1 repeated every 3--4 weeks. chemoimmunotherapy consisted of the same regimen plus c. parvum 2 mg/m2 i.v. daily for 14 days before every third cycle of chemotherapy, plus 2 mg/m2 i.v. daily on days 7 and 14 of each 21--28 day chemotherapy cycle. there was 32 evaluable chemotherapy an ... | 1982 | 7042068 |
| generation of tumor cells with reduced dna content as a result of macrophage tumoricidal activity. | 1982 | 7042078 | |
| regulation of the expression of adoptive tumor rejection immunity by recipient cyclophosphamide-sensitive cells. | peritoneal exudate t-cells from rats immune to 13762a rat mammary tumor conferred specific tumor rejection immunity on normal recipients. the efficiency of systemic adoptive transfer of tumor rejection immunity with immune peritoneal exudate t-cells was improved by cyclophosphamide (cy) pretreatment of recipients. optimal potentiation was obtained with a dose of 50 or 100 mg cy per kg body weight given the day before transfer. cy pretreatment of recipients was effective 1 to 3 days prior to tran ... | 1982 | 7042079 |
| distribution of igm, iga and igg secreting cells in the tissues of normal and tumour-bearing mice. | the levels of igm, iga and igg secreting cells were examined in control, corynebacterium parvum-stimulated and tumour-bearing, normal and athymic (nu/nu) mice. the percentage of iga to igm or igg secreting cells is relatively higher in peripheral blood than in the spleen or peritoneum of normal mice. within tumours, irrespective of their degree of vascularization and immunogenicity, the pattern of ig secreting cells in similar to that seen in peripheral blood and different from that in spleen an ... | 1982 | 7042550 |
| corynebacterium parvum and metastatic breast cancer. | 1982 | 7044404 | |
| intratumoral bcg and corynebacterium parvum therapy of canine mammary tumours before radical mastectomy. | in two parallel studies, bitches with mammary tumour received single intralesional injections of bcg (1 mg: 10(7) living bacteria) and corybacterium parvum (10(9) killed bacteria) (53 bitches) or c. parvum alone (129 bitches) at the same dosage. control groups received injections, following the same protocol, of 1 ml bcg suspension medium diluted in saline in the first study (51 bitches) or no injections at all (120 bitches in the second study). a block dissection, including mammary tumours, adj ... | 1983 | 6555059 |
| improved survival after pneumococcus in splenectomized and nonsplenectomized mice with corynebacterium parvum. | splenectomy increases the susceptibility to infections with certain bacteria, particularly streptococcus pneumoniae. because the immunomodulator corynebacterium parvum expands the phagocytic cell compartment and enhances reticuloendothelial function, we tested the effect of c parvum in mice challenged with aerosolized pneumococci. mice splenectomized seven days before pneumococcal challenge and treated intraperitoneally with 700 micrograms of c parvum immediately after exposure were protected wh ... | 1983 | 6824432 |
| intraperitoneal immunotherapy of human ovarian carcinoma with corynebacterium parvum. | corynebacterium parvum has been administered i.p. to 14 patients with advanced ovarian cancer. two patients had responded completely to cytoreductive surgery and combination chemotherapy prior to immunotherapy, and one patient with residual disease had received only a single course of c. parvum due to i.p. catheter malfunction. among the 11 patients with residual disease evaluable for response, from three to eight i.p. treatments with c. parvum produced surgically confirmed tumor regression in f ... | 1983 | 6825108 |
| inefficacy of sc corynebacterium parvum in stage i malignant melanoma: preliminary results of a single-institution pilot study. | 1983 | 6825130 | |
| new group of prostaglandin-like compounds in p. acnes. | 1983 | 6826037 | |
| isolation, identification, and synthesis of 2,3-diamino-2,3-dideoxyglucuronic acid: a component of propionibacterium acnes cell wall polysaccharide. | a previously undescribed component of the cell wall polysaccharide of propionibacterium acnes, 2,3-diamino-2,3-dideoxyglucuronic acid, has been identified and synthesized. the component occurs to the extent of about 3 to 5% in the wall polysaccharides of p. acnes types i and ii and in propionibacterium avidum types i and ii; it also appears to be present, but in much smaller amounts, in the cell wall of propionibacterium granulosum. | 1983 | 6826525 |
| evidence for granulocyte-mediated macrophage activation after c. parvum immunization. | it has been previously demonstrated that at the peak of the peritoneal response to corynebacterium parvum (day 4), cytolytic macrophages can be characterized by the presence of intracellular bacteria. in the present study, the role of neutrophils in the activation of peritoneal macrophages by c. parvum was investigated. inflammatory neutrophils isolated 5 hr after ip administration of c. parvum were transferred to normal, syngeneic mice and the peritoneal macrophages of recipients harvested 4 da ... | 1983 | 6831566 |
| production, purification, and properties of a bacteriocin from staphylococcus aureus isolated from saliva. | staphylococci from samples of human saliva were isolated on staphylococcal-selective agar plates. these strains were tested for the inhibition of the growth of staphylococcus aureus fda209p. the frequency of inhibitory strains among all of the staphylococcal isolates was 5.2%. strain iys2, which formed the biggest inhibitory zone against the growth of the indicator strain, was used as the producer of bacteriocin. iys2 was identified to be s. aureus, based on its biological properties. the bacter ... | 1983 | 6832811 |
| enhancement of natural resistance to influenza virus in lipopolysaccharide-responsive and -nonresponsive mice by propionibacterium acnes. | lipopolysaccharide-responsive c3h/hen mice were rendered resistant to a mouse-adapted strain of influenza (aichi, h(3)n(2)) virus when propionibacterium acnes was given either intranasally or intraperitoneally several days before virus infection. the time of p. acnes treatment was important since no protection was demonstrated when this agent was given either on the same day as or several days after virus challenge. in contrast, lipopolysaccharide-nonresponsive c3h/hej mice were not protected wh ... | 1983 | 6832817 |
| role of reduced sulfur compounds in nutrition of propionibacterium acnes. | in a study of the nutritional requirements of propionibacterium acnes, acid hydrolyzed casein was shown to be the preferred nitrogen source in a glycerol-salts medium. of 22 individual amino acids tested, only cysteine supported growth in the glycerol-salts medium. this indicated a requirement not only for amino nitrogen but also for reduced sulfur. in the presence of an auxiliary nitrogen source, thioglycolate or thiosulfate could replace sulfur-containing amino acids. the apparent requirement ... | 1983 | 6833481 |
| susceptibility of propionibacterium acnes clinical isolates to 22 antimicrobial agents. | susceptibilities of 104 propionibacterium acnes isolates to each of 22 antimicrobial agents was evaluated by broth microdilution. these isolates were susceptible to all of the test agents except metronidazole. n-formimidoyl thienamycin, a penem coded sch 29482, and penicillin ranked first, second, and third, respectively, in activity and were significantly more active than other penicillins, cephalosporins, tetracyclines, clindamycin, or chloramphenicol. | 1983 | 6838191 |
| intrapleural corynebacterium parvum for malignant pleural effusions. | a pilot study of topical (intrapleural) treatment with corynebacterium parvum was carried out in 10 patients with malignant pleural effusions complicating primary or secondary neoplasms and necessitating frequent thoracocentesis for symptomatic relief. the method was aspiration of all intrapleural fluid except a small portion left for dilution, and then injection of 7 mg of a preparation of corynebacterium parvum suspended in 20 ml of normal saline solution. the treatment was repeated in each ca ... | 1983 | 6845257 |
| an unusual cause of bacterial meningitis in the elderly. propionibacterium acnes. | 1983 | 6847449 | |
| inhibition of hepatic drug metabolism in the rat after corynebacterium parvum treatment. | drug-metabolizing enzyme activities, cytochrome concentration, and protein content of hepatic microsomal preparations from adult, female sprague-dawley rats were examined at 1-, 3-, 6-, 10-, 14- and 17-day intervals after administration of a single intravenous injection of corynebacterium parvum (c. parvum) at a dose of 10 mg/m2. aniline hydroxylase (ah) activity, aminopyrine demethylase (apd) activity, and cytochrome p-450 concentration were reduced 20-50% on days 3-6 and, thereafter, gradually ... | 1983 | 6847717 |
| immunopotentiation of cell-mediated hypersensitivity by corynebacterium parvum (propionibacterium acnes). | we have investigated the activity of local corynebacterium parvum (propionibacterium acnes) as an immunopotentiator of allergic contact dermatitis (acd) and photo-acd in rodents. c. parvum given into the sensitization site, but not at a distance, increased the delayed-type hypersensitivity to the chemical allergen. an immunoadjuvant effect could be realized even when c. parvum was given several days after allergen; it was readily obtained in b cell-deficient mice. cyclophosphamide pretreatment h ... | 1983 | 6848475 |
| enhancement of tumor metastasis and suppression of natural killer cell activity by beta-estradiol treatment. | treatment of mice with 17 beta-estradiol leads to a selective inhibition of natural killer (nk) cell activity as measured by in vitro cytotoxicity against yac-1 lymphoma and uv-2237 fibrosarcoma target cells. activation of nk cells by polyinosinic-polycytidylic acid (poly i.c) and corynebacterium parvum also was impaired in beta-estradiol-treated mice, whereas activation of tumoricidal macrophages was uncompromised. the beta-estradiol-induced suppression of nk cell activity was associated with a ... | 1983 | 6848604 |
| enhanced fc receptor expression by a sub-population of murine intra-tumour macrophages following intravenous corynebacterium parvum therapy. | intravenous injection of corynebacterium parvum (c. parvum) 4 days after s.c. inoculation of 5 x 10(5) cells derived from the immunogenic fibrosarcoma fsa/r induced tumour growth inhibition over a period of 21 days in syngeneic c3h/buf mice. this was not accompanied by a change in the proportions of host cells within the tumour, but the activation state of tumour-infiltrating macrophages was increased following c. parvum therapy. two macrophage subpopulations were identified in fsa/r tumours aft ... | 1983 | 6860547 |
| propionibacterium shunt nephritis in two adolescents with medulloblastoma. | the anaerobic diphtheroid propionibacterium acnes was identified as the organism responsible for "shunt" nephritis in two adolescents with ventriculoatrial shunts inserted previously for the management of medulloblastoma. only three cases of "shunt" nephritis secondary to infection with this common skin commensal organism are known to have been reported. the rarity of such reports may be related to the lack of good anaerobic laboratories, the length of time necessary for cultures to show growth, ... | 1983 | 6861076 |
| protection of mice against influenza virus infection: enhancement of nonspecific cellular responses by corynebacterium parvum. | groups of c57bl/6j, balb/c, balb/c, nu+/nu+ mice, inoculated intranasally with corynebacterium parvum (350 micrograms/mouse) were protected from death by an otherwise lethal dose of influenza virus, a/wsn (h1n1) inoculated 3 days later. the lungs of c. parvum-treated, virus-infected c57bl/6j, balb/c, or balb/c nu+/nu+ mice contained significantly less infectious virus than did controls, and this reduction was apparent as soon as 24 hr after virus inoculation. the maximum protective effect correl ... | 1983 | 6861206 |
| bacteriological study in chronic maxillary sinusitis. | the bacterial findings of 73 maxillary sinuses in 48 patients with chronic maxillary sinusitis, together with 7 non-inflamed sinuses, are reported. employing an intraoperative technique and simultaneous collection of 3 different types of specimens in the present investigation made possible comparison of their bacterial characteristics. the results indicated that intraoperative culture of antral mucosa seems to provide the most reliable finding of bacterial flora in chronic maxillary sinusitis. t ... | 1983 | 6865629 |
| leishmania tropica major in mice: vaccination against cutaneous leishmaniasis in mice of high genetic susceptibility. | balb/c and balb/c.h-2b mice are genetically susceptible to development of persistent and severe disease following cutaneous injection of promastigotes of the protozoan parasite, leishmania tropica major, whereas c57bl/6 are relatively resistant. resistance in c57bl/6 can be further increased by intraperitoneal injection of living, but not killed, promastigotes prior to cutaneous challenge. severely diseased balb/c mice can show resistance to development of a second cutaneous lesion but apparentl ... | 1983 | 6870673 |
| platelet activating factor (paf) induces the oxidative burst in macrophages. | the response of guinea pig peritoneal macrophages to platelet activating factor (1-o-octadecyl-2-acetyl-sn-glycero-3-phosphoryl-choline) was examined. in corynebacterium parvum induced macrophages, platelet activating factor, over a wide dose range (3.8 x 10(-5) to 3.8 x 10(-9)m) triggered the oxidative burst as indicated by increased luminol-dependent chemiluminescence and hydrogen peroxide release into culture supernatants. this effect of paf was inhibited by superoxide dismutase and catalase. ... | 1983 | 6874164 |
| augmentation of nk activity by corynebacterium parvum fractions in vivo and in vitro. | biochemically modified whole cell preparations and derived fractions of corynebacterium parvum (c. parvum) were evaluated for the ability to augment natural killer cell cytoxicity in vivo and in vitro in rats. unfractionated c. parvum enhanced peritoneal cell (pc) nk activity in a dose dependent fashion. this activity appeared to be enriched in insoluble light residue material obtained from hot phenol water extraction. enhancement of pc cytotoxicity was significantly greater at all time points t ... | 1983 | 6874167 |
| new antibiotic, isohematinic acid. ii. physico-chemical properties, structural elucidation and biological activities. | physico-chemical characterization of isohematinic acid revealed that this antibiotic has a succinimide nucleus. from elemental analysis, the molecular formula of isohematinic acid was determined to be c8h9no4. isohematinic acid showed weak antimicrobial activities against anaerobic bacteria, such as bacteroides fragilis and propionibacterium acnes. | 1983 | 6874567 |
| the effect of benzoyl peroxide on cutaneous micro-organisms in vitro. | the survival curves of cutaneous micro-organisms in the presence of benzoyl peroxide were investigated. all the curves exhibited a shoulder prior to exponential cell death. benzoyl peroxide was lethal to the cutaneous organisms tested and they varied in sensitivity increasing as follows: propionibacterium acnes, staphylococcus capitis, staph. epidermidis, staph. hominis, prop. avidum, prop. granulosum and pityrosporum ovale. | 1983 | 6874624 |
| [treatment of resistant pulmonary tuberculosis using chemotherapy and immunomodulators]. | 1983 | 6879325 | |
| oxygen and serum complement in phagocytosis and killing of propionibacterium acnes. | phagocytosis and killing of propionibacterium acnes by human peripheral blood leukocytes were promoted by normal human serum and by serum depleted of immunoglobulin g and m. serum that had been heat-inactivated, depleted of complement component c3, or depleted of c4 and factor b, did not promote phagocytosis or killing. depletion of complement-component c4 or factor b from normal human serum did not impair its capacity to promote phagocytosis and killing of p. acnes. these results indicate that ... | 1983 | 6880750 |
| mechanisms of the potentiation of specific antitumor immunity by intratumor injection of corynebacterium parvum. | meth a fibrosarcoma-bearing balb/c mice given intratumoral injections of 0.5 mg of corynebacterium parvum showed a highly and tumor-specific transplantation antigen specifically potentiated concomitant immunity to a subsequent tumor challenge. this potentiated antitumor immunity could be locally transferred in the winn assay to normal recipients with whole draining lymph node cells from the tumor-bearing mice, but the potentiated effect disappeared when adherent cells were removed from these cel ... | 1983 | 6883325 |
| intracavitary corynebacterium parvum for treatment of malignant effusions. | intracavitary instillation of corynebacterium parvum was used to treat recurrent malignant effusions in 15 patients. eleven patients were treated for ascites, and four patients were treated for pleural effusion. six patients (40%) had good response with no recurrence of effusions up to 3 months after treatment. three patients responded but died before criteria for complete response could be fulfilled. six patients were judged to have poor response, either because of death from tumor burden befor ... | 1983 | 6884832 |
| differential effects of chronic monocyte depletion on macrophage populations. | the administration of the bone-seeking isotope, 89sr, to mice results in severe monocytopenia without any apparent effect on the numbers of resident peritoneal macrophages (mphi). an explanation for this dichotomy was sought by determining whether the residual blood monocytes were still an effective source of mphi after 89sr treatment. stem cell enumeration showed that a 90% fall in bone marrow macrophage colony-forming cells after 89sr was accompanied by a 10-fold rise in splenic m-cfc. splenec ... | 1983 | 6887784 |
| the growth and spontaneous dissemination of melanoma b16 and lewis lung tumour in two sub-strains of c57bl/6j mice treated with corynebacterium parvum and/or levamisole. | the effect of c. parvum and/or levamisole on tumour growth and spontaneous dissemination was tested in two tumour-host systems, melanoma b16 and llt in c57bl/6j mice. c. parvum inhibited the growth of llt and its dissemination to the lungs and the growth of b16 in females in one of the two sub-strains of mice used. levamisole stimulated the growth of b16 in females in one sub-strain and in both sexes in the other sub-strain of mice. the growth of llt was not influenced by levamisole but its diss ... | 1983 | 6546203 |
| the role of immunotherapy in acute myelogenous leukemia. | the use of immunotherapy for acute myelogenous leukemia (aml) is controversial. twenty-four trials have been reported in which 1,491 patients with aml received various forms of immunotherapy, including bcg, methanol extract residue (mer) of bcg, or corynebacterium parvum. some patients were immunized with allogeneic or autologous leukemia blast cells. in only four of the 24 trials was a significant prolongation of remission reported. pooled data from all 24 studies were analyzed further. no stat ... | 1983 | 6577818 |
| chemotherapy and corynebacterium parvum for induction and maintenance of remission in acute myelogenous leukaemia--a controlled study. | 1983 | 6580265 | |
| solid tumor-derived target cell susceptibility to macrophages and natural killer/natural cytotoxic cells in the rat. | cytotoxic capacity of rat macrophages (m phi) and natural killer (nk)/natural cytotoxic cells (nc) against adherent growing, solid tumor-derived target cells was evaluated, modulating the activation status of effector cells and growth conditions of target cells. testing a panel of target cells, cytotoxicity of nk/nc and m phi was strikingly correlated so that besides of target-cell binding structures basic lysability seems to be of influence with respect to cytotoxicity rates. varying the in viv ... | 1983 | 6603412 |
| role of corynebacterium parvum in the activation of peritoneal macrophages. ii. identification of distinguishable anti-tumor activities by macrophage subpopulations. | two different mechanisms of murine macrophage (mp) antitumor activity are described in this report. c. parvum-activated peritoneal mps were tested for cytotoxic and cytostatic activity 4 days after ip immunization. cytotoxic activity could be distinguished from cytostatic activity using two different assay protocols. when mps were separated by 1g velocity sedimentation, cytotoxic mps were confined to high velocity fractions. in contrast, cytostatic mps were found in cell fractions with velocitie ... | 1983 | 6219754 |
| effects of treatment with erythromycin 1.5 percent topical solution or clindamycin phosphate 1.0 percent topical solution on p. acnes counts and free fatty acid levels. | twenty healthy subjects (7 men and 13 women) with average baseline p. acnes counts equal to or greater than 1.0 x 10(5) were treated twice a day for eleven days in a randomized, double-blind study with either erythromycin 1.5 percent topical solution or clindamycin phosphate 1.0 percent topical solution. p. acnes counts and free fatty acid (ffa) measurements were performed before treatment, and on days 4 and 11 of treatment. statistically significant reductions in p. acnes counts were produced i ... | 1983 | 6220870 |
| comparative activity of benzoyl peroxide and hexachlorophene. in vivo studies against propionibacterium acnes in humans. | the bactericidal effects of benzoyl peroxide (5% lotion) and hexachlorophene (3% colloidal suspension) against propionibacterium acnes were compared in nine healthy college students who had the microbiological and skin lipid characteristics typical of acne vulgaris, but no active lesions. each of the two medications was applied twice daily, to opposite sides of the face, for four consecutive weeks. hexachlorophene was effective against surface aerobes but only slightly active against p acnes. it ... | 1983 | 6222704 |
| studies of the extracellular proteolytic activity produced by propionibacterium acnes. | of several commercial media tested, trypticase soya both containing 0.4% (w/v) d-sorbitol was superior as a growth medium for the production of extracellular proteinase by propionibacterium acnes (strain p-37). extracellular proteinase, production of which was shown to be growth-associated by both batch and continuous culture studies, was partially purified by 70% (nh4)2so4 saturation. sephadex g-75 chromatography and ion exchange on deae-sephadex a-50. it was shown to be a heterogeneous mixture ... | 1983 | 6406421 |
| an evaluation of the antifungal effect of bifonazole on torulopsis glabrata and candida albicans under various in vitro test conditions. | 1-[(4-biphenylyl)-phenylmethyl]-1h-imidazole (bifonazole, bay h 4502, mycospor) showed in vitro significant inhibitory activity against torulopsis glabrata, candida albicans, pityrosporum ovale, corynebacterium acnes and staphylococcus epidermidis. the antifungal activity of bifonazole against t. glabrata and c. albicans varied with the in vitro test conditions. there was a tendency for minimal inhibitory concentrations to increase as fungal inoculum size was increased and as incubation time was ... | 1983 | 6409128 |
| kinetics of killing listeria monocytogenes by macrophages: rapid killing accompanying phagocytosis. | the kinetics of bactericidal activity of activated macrophages can be precisely described by a mathematical model in which phagocytosis, killing, digestion, and release of degraded bacterial material are considered to occur continuously. to gain a better understanding of these events, i have determined the period of time between first contact of bacteria with macrophages and the onset of killing. activated rat peritoneal macrophages were incubated for various times up to 15 min with listeria mon ... | 1983 | 6411918 |
| adjuvant immune stimulation with corynebacterium parvum during maintenance chemotherapy of acute myeloid leukemia. a prospective randomized study. | of 93 consecutively treated patients with acute myeloid leukemia 36 (39%) achieved complete remission (cr). thirty-five patients were randomized to receive either maintenance chemotherapy alone (c) or a combination of active nonspecific immunotherapy with corynebacterium parvum and chemotherapy (c + i). maintenance therapy was given monthly for 1 year or until relapse. the median survival time was 21 months for patients treated with chemotherapy alone, compared with 30 months for patients treate ... | 1983 | 6420046 |
| [a case of spondylodiscitis caused by propionibacterium acnes and peptococcus constellatus]. | 1983 | 6612203 | |
| suppressive effects of corynebacterium parvum on primary and secondary antibody responses in mice. | the splenic plaque forming cell (pfc) response of mice to an intraperitoneal injection of sheep erythrocytes was severely depressed by prior treatment with corynebacterium parvum given four days beforehand by the same route. however, total antibody levels were less affected, and soon attained near normal titres. this implied that the effects of c. parvum were limited to the spleen, and that other tissues gave a substantial response during the period when the splenic response was suppressed. equa ... | 1983 | 6620257 |
| [antigenic relationship between the chemically-induced mouse bladder tumor and corynebacterium parvum]. | 1983 | 6620769 | |
| effects of the removal of the primary tumor and immunotherapy with corynebacterium parvum on metastatic tumor proliferation. | the effects of surgical intervention by removal of the primary focus, and the effectiveness of an immunomodulator, corynebacterium parvum (cp), on the proliferation of metastatic tumor tissue were investigated by following the postoperative changes in the 3h-thymidine labelling rate of metastatic tissue in an experimental model of metastasis in mice. in addition, the delayed type hypersensitivity reaction (dth) was studied to investigate the immune capacity of the host. the labelling rate of mic ... | 1983 | 6624533 |
| treatment of advanced ovarian malignancy with chemoimmunotherapy using autologous tumor and corynebacterium parvum. | fourteen patients with advanced ovarian epithelial carcinoma were treated with a combination of chemotherapy and immunotherapy. the chemotherapy consisted of either melphalan or a combination of adriamycin, cytoxan, and cisplatin. the immunotherapy consisted of the injection of autologous radiation-attenuated tumor and corynebacterium parvum. no significant toxicity occurred as a result of the immunotherapy, and there was no evidence of tumor growth at the sites of injection. the autologous tumo ... | 1983 | 6633998 |
| coparvax for malignant effusion? | 1983 | 6641514 | |
| organ distribution of tritium labeled corynebacterium parvum in mice. | 1983 | 6645221 | |
| [corynebacterium acnes osteitis. a case in a child]. | the authors report a case of corynebacterium acnes osteitis in an 11 year old girl, involving the upper of the right tibia. the lesion resembled a malignant tumour radiologically and tuberculosis histologically. scintigraphy revealed involvement of the seventh right rib. 3 months treatment with pristinamycin resulted in cure. | 1983 | 6646947 |
| protection of cattle against theileria annulata infection using corynebacterium parvum. | four groups of calves (a, b, c and d) each consisting of five calves were used for the present study. group a calves were given corynebacterium parvum alone. group b calves were inoculated with inactivated ground-up-tick supernate (guts) prepared from hyalomma anatolicum anatolicum infected with theileria annulata plus c. parvum. group c received only inactivated guts. all the surviving calves of groups a to c were exposed on day 45 post-inoculation to a lethal tick challenge along with suscepti ... | 1983 | 6649060 |
| growth of propionibacterium acnes strains on semisynthetic medium; antigenic polysaccharide production. | a semisynthetic medium, containing yeast extract as the only non defined component and glucose, glycerol, tween 80 and mineral salts, has been developed to grow the strains of propionibacterium acnes beck 2037, gerrath 2038 and vogel 2039, at a rate comparable to that of complex media. an average of 10(12) cells per 1 (equivalent to approximately 1.5 g/l dry weight) was usually achieved. these yields are appropriated for biochemical and immunological studies, e.g. cell wall preparation, polysacc ... | 1983 | 6649955 |
| the influence of endotoxin in vitro on hepatic macrophage lysosomal enzyme release in different rat models of hepatic injury. | since bacterial endotoxin is known to be involved in the pathogenesis of hepatic injury, the influence of endotoxin on lysosomal enzyme production by hepatic macrophages has been investigated. macrophages have been isolated from the livers of normal rats, from the livers of rats given stilboestrol subcutaneously 4 days previously and from the livers of rats given corynebacterium parvum intravenously 6 days previously. following isolation and overnight culture, the macrophages have been maintaine ... | 1983 | 6651924 |
| acute polyarthritis following the use of corynebacterium parvum vaccine (coparvax) for malignant pleural effusion. | a 77-year-old man with a malignant pleural effusion was treated by aspiration of fluid and injection of corynebacterium parvum vaccine for pleurodesis. within 24 hr he had developed a temperature and a neutropenia followed by an acute crippling polyarthritis of his hands and wrists which subsequently responded to oral steroids and non-steroidal antiinflammatory drugs. | 1983 | 6657546 |
| response of tumors to biologic modifiers and chemotherapeutic agents. | the use of the fanft model has facilitated clinical trials which are now beginning to have an impact on the therapy of human bladder tumors. we studied c. parvum and glucan immunotherapy of fanft tumors, and demonstrated the enhancement of tumor growth following glucan administration. weekly injections of cyclophosphamide (cy) retarded tumor growth and increased survival. combining c. parvum or glucan with cy resulted in greater tumor growth inhibition than cy alone. our data support the concept ... | 1983 | 6658848 |
| [mechanism of the antitumor immunity potentiated by anaerobic corynebacterium parvum]. | 1983 | 6662469 | |
| effects of oxygen concentration on biomass production, maximum specific growth rate and extracellular enzyme production by three species of cutaneous propionibacteria grown in continuous culture. | propionibacterium acnes, propionibacterium avidum and propionibacterium granulosum were grown in continuous culture at 0-100% air saturation using a semi-synthetic medium. maximum specific growth rate, biomass concentration and extracellular lipase, hyaluronate lyase and phosphatase activities were determined. all three species were capable of growth at 100% air saturation but at reduced growth rates. the presence of oxygen altered the production of extra-cellular enzymes. propionibacterium avid ... | 1983 | 6663280 |
| [etiological investigation of propionibacterium acnes variant isolated from children with kawasaki disease]. | 1983 | 6663741 | |
| [current trends in immunotherapy of tumors of the lung]. | 1983 | 6675558 | |
| [the effects of surgical intervention and removal of the primary tumor, and the effectiveness of corynebacterium parvum on metastatic tumor proliferation]. | the effects of surgical intervention and removal of the primary tumor, and the effectiveness of corynebacterium parvum (cp) on the proliferation of metastatic tumor tissue were investigated by using autoradiography to follow post-operative changes in the 3h-thymidine labelling rate of metastatic tissue in an experimental model of metastasis in mice. in addition, the delayed hypersensitivity reaction and the cytotoxicity (adcc, nk) of lung cells were studied, to investigate the immune capacity of ... | 1983 | 6676630 |
| changes in anatomical distribution of tumour lesions induced by platelet-active drugs. | to examine the effect of platelet-active drugs on the spread of blood-borne tumour cells, two murine tumours, sarcoma 180 (s-180) and tlx-5 lymphoma, were selected. following intravenous (iv) injection into cba mice the former elicited thrombocytopenia and formed discrete pulmonary tumours, whereas the latter failed to elicit thrombocytopenia and formed discrete tumours in all visceral organs examined except the lungs. s-180 cells were injected iv into mice pre-treated with ra233 (known to preve ... | 1983 | 6677619 |
| effect of corynebacterium parvum in the induction and course of mycoplasma arthritis of mice. | the effect of the immunostimulant c. parvum on the establishment and course of mycoplasma arthritis of mice was investigated. male swiss albino mice were injected intra-venously with m. arthritidis culture and intraperitoneally with c. parvum. it was shown that mice immunostimulated with c. parvum were significantly protected against the establishment of arthritis if the mycoplasma was given 9 days after the immunostimulant. however, when the arthritis was established c. parvum had no effect on ... | 1983 | 6678690 |
| in vitro activity of u-57930e against anaerobic bacteria and its comparison with clindamycin, ampicillin, carbenicillin and tetracycline. | the in vitro activity of u-57930e, a pipecolic acid amide of clindamycin, was compared with those of clindamycin, ampicillin, carbenicillin and tetracycline against 321 anaerobic clinical isolates. the mic (micrograms/ml) of u-57930e that inhibited 95% bacteroides fragilis, peptococcus prevotii, b. melaninogenicus and p. asaccharolyticus was 0.0625; 0.03125 for peptostreptococcus anaerobius, b. vulgatus, propionibacterium and peptococcus species. clindamycin, on the other hand, gave mic values o ... | 1983 | 6678915 |
| new therapeutic approaches to treatment of malignant gliomas: chemotherapy and immunotherapy. | 1983 | 6680086 | |
| non-specific immunization against bovine tropical theileriosis (theileria annulata) using killed corynebacterium parvum. | killed corynebacterium parvum was used as an adjuvant for the production of non-specific resistance against theileria annulata in cattle. groups of cross-bred (bos indicus x bos taurus) calves were administered c. parvum adjuvant subcutaneously and were then challenged with t. annulata-infected ticks on 45, 60 or 90 days later. the challenge caused mild reactions in the protected calves. none of the 10 immunized calves died due to theileriosis, whereas all three paris of susceptible control calv ... | 1983 | 6685397 |
| tuftsin stimulates the release of oxygen radicals and thromboxane from macrophages. | the physiologically occurring tetrapeptide, tuftsin (thr-lys-pro-arg), was examined for its effects on guinea pig peritoneal macrophages. adherent macrophages (møo) were exposed to tuftsin at concentrations ranging from 10(8) to 10(6) m, and the release of oxygen radicals and the arachidonic acid cyclo-oxygenation product, thromboxane b2 (txb2), was studied. tuftsin causes both albumin-elicited and c. parvum-activated møo to set free superoxide anion (o2) and hydrogen peroxide (h2o2). it also st ... | 1983 | 6687720 |
| anti-p. acnes antibody in comedonal extracts. | extracts of comedonal material obtained from patients with acne vulgaris were analyzed for albumin, igg, igm, iga, and anti-propionibacterium acnes antibodies using immunodiffusion and anti-immunoglobulin hemagglutination tests. extracts were obtained from comedones of patients with (1) comedonal, (2) papulopustular, (3) nodular-cystic, (4) "burned out" acne, (5) patients under oral tetracycline treatment, and (6) with pustules. in all comedonal extracts analyzed, albumin and igg (ratio approxim ... | 1983 | 6217259 |
| propionibacterium acnes resistance to antibiotics in acne patients. | the minimal inhibitory concentration (mic) of propionibacterium acnes in seventy-five acne patients receiving long-term antibiotic therapy demonstrated the emergence of resistant strains. the mean mic in thirty-three patients receiving long-term tetracycline was four to five times higher than that found in control groups of acne patients not receiving antibiotic therapy and controls free of acne. the average mic for erythromycin was more than 100 times higher in those receiving long-term antibio ... | 1983 | 6219134 |
| regulation of natural killer cell activation: implementation for the control of tumor metastasis. | the cellular interactions that regulate natural killer (nk) cell-mediated cytotoxicity and antimetastatic activity following treatment with biological response modifiers (brm) were studied. the transient activation of nk cells by a single injection of corynebacterium parvum is followed by a refractory period during which a second injection of brm fails to stimulate the already depressed nk cell activity. during this hyporesponsive period, the in vivo nk cell-dependent brm-induced antimetastatic ... | 1983 | 6235447 |
| inhibition of natural killer cell activity by a soluble substance released by rat peritoneal cells. | we describe here a soluble substance released by nonadherent cells from the peritoneal cavity of w/fu rats that markedly inhibits the activity of mouse, rat, and human natural killer (nk) cells. the nk-inhibiting substance (nk-is) has low molecular weight (less than 1000), is heat resistant (100 degrees for 15 min), and is insensitive to nonspecific proteases. nk-is is produced in the presence of indomethacin (1 to 10 micrograms/ml), suggesting it is not prostaglandin. the inhibitory effect was ... | 1983 | 6339046 |
| effects of treatment with muramyl dipeptide on resistance to mycobacterium leprae and mycobacterium marinum infection in mice. | studies were carried out to determine whether treatment of mice with the synthetic adjuvant muramyl dipeptide (mdp) afforded resistance to infection with mycobacterium leprae or m. marinum in mice. regardless of the timing, dose, or route of administration, there was no evidence that treatment with mdp or 3 of its analogs (desmdp, abumdp, valmdp) enhanced resistance to food pad infection with m. leprae or m. marinum. in parallel studies, systemic treatment with propionibacterium acnes failed to ... | 1983 | 6343295 |
| comparison between natural reactivity (nr) against candida albicans and natural killer (nk) activity against yac-1 tumour cells. | cytotoxic activity against candida albicans was measured in vitro in a 4-h 51cr-release assay. the levels of reactivity correlated well with the number of polymorphonuclear cells in the effector population, being augmented by the enrichment of polymorphonuclear granulocytes. to exclude the possible role of contaminating natural killer cells, natural killer activity against tumour cells was compared with natural reactivity against candida albicans in vitro. the findings indicate that there are ma ... | 1983 | 6345429 |
| cellular suppression of murine adcc and nk activities induced by corynebacterium parvum. | administration of a single dose of c. parvum (cp) induces depression of splenic nk activity in mice after a lag period of 3-5 days and this depression lasts about 2 weeks. the depressed levels of nk activity noted in this study depended on time of cp administration and were associated with the induction of suppressor cell activity. neonatally thymectomized or sublethally irradiated mice had unimpaired ability to generate suppressor cells following cp treatment. depletion of adherent/phagocytic c ... | 1983 | 6347362 |
| increased susceptibility to escherichia coli infection in mice pretreated with corynebacterium parvum. | the contribution of activated macrophages to protection against escherichia coli was studied in mice treated intravenously with corynebacterium parvum 7 days before infection. c. parvum-treated mice showed increased phagocytic activity and enhanced resistance to listeria infection. in contrast, these mice showed increased susceptibility to a subsequent challenge with e. coli that correlated closely with a reduction in the ld50 of lipopolysaccharide (lps) in these mice. the peritoneal macrophages ... | 1983 | 6348489 |
| membrane changes in murine macrophages after in-vivo stimulation and activation. | the expression of various receptors and other surface determinants on resident, glycogen-and corynebacterium parvum- elicited mouse peritoneal macrophages has been described. macrophage fc (igg2b) receptors and i-a antigens were slightly increased after stimulation and a more marked increase was shown after activation with c. parvum. complement receptor expression was enhanced after stimulation but was markedly reduced after activation. c. parvum-elicited macrophages, and to a lesser extent glyc ... | 1983 | 6350168 |
| [immunotherapy of breast cancer (review of foreign literature)]. | 1983 | 6351428 | |
| anemia and thrombocytopenia from corynebacterium parvum-stimulated resistance against malaria, trypanosomiasis, and babesiosis. | nonspecific immunity (nsi) was manifested in rats injected intravenously with killed corynebacterium parvum and challenged with trypanosoma lewisi, plasmodium chabaudi, or babesia rodhaini. the nsi became evident some 5 days after infection as a suppressed parasitemia, a more rapid recovery from patent infection and as enhanced survival among rats infected with b. rodhaini. the c. parvum injections produced anemia and thrombocytopenia with splenomegaly and signs of glomerulonephritis in rats. th ... | 1983 | 6355427 |
| production of lymphocyte activating factor in vivo. | mice injected with propionibacterium acnes, when challenged with lipopolysaccharide release a range of soluble mediators into their serum. included among these is lymphocyte activating factor (laf, interleukin-1). the release of laf in vivo was detected only when serum samples were assayed at high dilution because inhibitors of its activity in vitro were also present. the kinetics of release of laf in vivo after injection of p. acnes was dependent on the mouse strain used. laf was also detected ... | 1983 | 6360852 |
| a phase-ii trial of corynebacterium parvum as adjuvant to surgery in the treatment of operable lung cancer. | a phase-ii randomized trial has been undertaken in 49 patients with operable lung cancer, to determine the effect of a single iv infusion of killed c. parvum vaccine as an adjuvant to surgery. the number of patients was insufficient to provide a decisive result, but analysis 6 years after the last patient was admitted shows that the adjuvant therapy certainly did not shorten, and may well have prolonged, survival. of the patients with squamous cell carcinoma who were alive 1 year after operation ... | 1983 | 6362846 |
| role of natural killer cells in host defense against cancer metastasis. | 1983 | 6382510 | |
| suppression of in vitro maintenance and interferon-mediated augmentation of natural killer cell activity by adherent peritoneal cells from normal mice. | the ability of adherent peritoneal cells (apc) to inhibit murine natural killer (nk) cell activity was examined. nylon wool-nonadherent splenic effector cells were incubated overnight with or without different numbers of apc. nk activity was then measured against yac-1 in a 4-hr 51cr-release cytotoxicity assay. proteose peptone-elicited or unstimulated resident apc from normal mice markedly suppressed nk activity of splenic effector cells in the presence or absence of exogenously added interfero ... | 1983 | 6187831 |
| interferon-induced 2'-5' adenylate synthetase in vivo and interferon production in vitro by lymphocytes from systemic lupus erythematosus patients with and without circulating interferon. | the interferon (ifn)-induced enzyme 2-5a synthetase was elevated in mononuclear cells from both serum ifn-positive and -negative systemic lupus erythematosus (sle) patients. this suggests that a much higher percentage of patients than previously thought produce endogenous ifn. these results may partly explain findings that mononuclear cells from sle patients are deficient in ifn production in vitro in response to certain ifn inducers. although normal lymphocytes can produce an acid-labile alpha ... | 1983 | 6189954 |
| effects of various coryneforms on mononuclear phagocyte system function and on production of tumour necrosis factor in mice. | vaccines of 6 strains of the genera corynebacterium and propionibacterium were tested for induction of hepatosplenomegaly and stimulation of clearance of injected colloidal carbon and viable listeria monocytogenes. these effects were compared with the ability of these strains to support the endotoxin-induced liberation of tumour necrosis factor, interferon and heat-stable cytostatic factors in mouse circulation. five strains caused good stimulation of macrophage functions and induced high levels ... | 1983 | 6190428 |
| [immunology - results of two decades of immunological research]. | the discipline of immunology has made very rapid progress during the past twenty years. a general introductory part was followed by a discussion of immunological components in resistance. subsequently, the importance of controlling the immunological system was stressed. the significance of the network theory was briefly referred to. attention was then drawn to specific and non-specific stimulation of the immune response, which are essential both in theory and in actual practice. a number of inst ... | 1983 | 6191405 |
| regulation of cytotoxic reactivity to minor histocompatibility antigens by administration of corynebacterium parvum. | b10.br(h-2k) mice were primed with h-2-identical allogeneic cba/j(h-2k) spleen cells and restimulated in vitro 14 days later to generate specific secondary cytotoxic lymphocytes. a single intravenous injection of primed mice with 700 micrograms of corynebacterium parvum 7 days after alloimmunization markedly inhibited the subsequent secondary in vitro generation of cytotoxic cells. in addition, regulatory spleen cells were detected in alloimmunized c-parvum-injected mice that prevented the resti ... | 1983 | 6191416 |
| inhibition of natural killer cell lysis by natural killer-inhibitory substance: mechanism of suppression. | the mechanism of suppression of nk-mediated lysis by a soluble product of peritoneal cells (nk-is, natural killer-inhibitory substance) was investigated. pretreatment of effector cells resulted in depressed nk lysis while pretreatment of targets had no effect, indicating suppression is due to alterations in effector cell function rather than changes in target cells. nk-is had no effect on the formation of conjugates between effectors and nk-susceptible targets. when nk-is was added to effector-t ... | 1983 | 6191875 |
| effect of coordinated therapeutic assays using c. parvum, interferon and arginine butyrate on spontaneous disease and survival of akr mice. | akr mice, known to develop spontaneous leukemia in almost 100% of cases, were studied throughout their life-span. different treatments combining a potent immune stimulator, corynebacterium parvum (cp), with interferon (ifn) and arginine butyrate were initiated at the 15th week of life. in a preliminary series of experiments, cp (200 micrograms), ifn (20,000 units) and butyrate 50 mm) were employed in a well-defined chronological order. in controls, the mean survival time (mst) was 35.17 +/- 1.67 ... | 1983 | 6193071 |
| immunotherapy of ovarian cancer. | 1983 | 6193921 | |
| isolation of anaerobic and aerobic bacteria from clean surgical wounds: an experimental and clinical study. | a pad imprint method was evaluated for quantitative sampling of anaerobic and aerobic bacteria from clean surgical wounds. the best recovery of bacteria from the pads was obtained when they were treated with a rinsing solution in a 'stomacher' apparatus. pads of three different fabrics were compared, but no difference was noted in their efficiency in sampling anaerobic and aerobic bacteria from clean surgical wounds. sampling of known quantities of staphylococcus aureus from experimental wounds ... | 1983 | 6195222 |
| mode of protection of mice against herpes simplex virus type 2 infection by propionibacterium. | we compared various strains of propionibacterium with regard to protection of young adult mice against lethal infection with herpes simplex virus type 2 (hsv-2). propionibacterium acnes, p. granulosum, and p. avidum were protective, while p. acidi-propionici and p. lymphophilum were ineffective. the protective effect proved to be in the cell wall fraction. attempts were made to elucidate possible mechanisms of the protection using both effective and ineffective strains. the results strongly sugg ... | 1983 | 6195512 |
| immunologic therapies of kidney carcinoma. | 1983 | 6198729 | |
| [antitumor effect of corynebacterium parvum and poly iclc on experimental brain tumors]. | 1983 | 6201759 | |
| tumor-dependent resistance of rat peritoneal macrophages to herpes simplex virus. | by their position at sites of initial infection and their wide distribution in major organs of the body, macrophages may be decisive in determining the susceptibility or resistance of the host to virus infection. macrophage restriction of virus replication has been shown to be closely related to virus strains or virus types and to the age of the infected host. we report the effects of the development of a solid tumor in rats on intrinsic in vitro macrophage activity against herpes simplex virus ... | 1983 | 6299945 |
| induction of resistance to ectromelia virus infection by corynebacterium parvum in murine peritoneal macrophages. | an in vitro model has been developed to study the replication of ectromelia virus in murine macrophages (m phi). infection of mineral oil-elicited peritoneal m phi cultures with either the virulent (moscow) or attenuated (hampstead) strain of ectromelia virus led to productive infections. the kinetics of virus synthesis was similar to those seen following infection of murine fibroblasts. in contrast, peritoneal m phi s activated by intraperitoneal injection of corynebacterium parvum vaccine were ... | 1983 | 6300395 |