Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| [investigation of serological features and molecular heterogeneity of virion proteins of morphologically related phages]. | some interaction process peculiarites of morphologically related phate t4, ddvi and fi1 with the corresponding antiphageous sera in cross reactions of neutralisation have been investigated. close serological relationship of phage t4 and ddvi was demonstrated. inactivation of phage fi1 in these serological reactions showed anomalous nature and did not submit to the rules of the first step reaction. according to investigations of the protein component of virions of these phages by electrophoresis ... | 1979 | 91945 |
| the influence of non-steroidal anti-inflammatory and antithyroid agents on myeloperoxidase-catalysed activities of human leucocytes. | viable leucocytes obtained fresh from normal human subjects were shown to be able to catalyse the in vitro iodination of bovine serum albumin (bsa) in a h2o2-generating system. the rate and degree of iodination were greatly improved by sonication of the cells. a balanced salt solution was a more favourable medium than phosphate buffer for the myeloperoxidase (mpo)-catalysed iodination of whole cells and sonicated cells. reactions known to be catalysed by other peroxidases (e.g. thyroid peroxidas ... | 1979 | 89704 |
| spinal ganglion cells innervating the stomach of the rat as demonstrated by somatopetal transport of horseradish peroxidase (hrp). | spinal ganglion cells innervating the stomach of the rat were demonstrated using the somatopetal horseradish peroxidase (hrp) transport technique. after injection of the tracer into the anterior wall of the stomach, labelled neurons were observed bilaterally within spinal ganglia t4--l1. they were most numerous in ganglia t8--t10. no clear evidence of somatotopic organization of the labelled cells was found. most of the cells measured 35--40 micrometer in diameter. there was a striking paucity o ... | 1979 | 88192 |
| short-term triiodothyronine in prevention of temporary hypothyroidism after subtotal thyroidectomy for graves' disease. | to determine whether short-term thyroid hormone replacement prevents or merely delays temporary hypothyroidism after surgery for graves' disease, serum t3, thyroid-stimulating hormone, and t4 were measured every 2 months for 18 months in two groups of graves' disease patients who had had subtotal thyroidectomy. group i (18 patients) were given t3 20 microgram four times daily from surgery through the twelfth postoperative month. group ii (18 patients) received no treatment. hypothyroidism occurr ... | 1979 | 87965 |
| euthyroid high total t4, normal t3 syndrome. | 1979 | 87650 | |
| [hormone concentrations in thyroid gland tissue and plasma in autonomous thyroid adenomas with and without thyrostatic pretreatment]. | the thyroid hormone concentrations of t2, t3 (and the inactive r-t3) were determined in thyroid tissue of 20 patients with autonomous adenomas. high concentrations were found in scintigrafically decompensated adenomas without preoperative thyrostatic treatment. decompensated adenomas after thyrostatic treatment, compersated adenomas and a group of 9 euthyroid goiters showed no difference in tissue-concentrations of t4 and t3. the amount of tissue-r-t3 seems to be lowered in autonomy. the plasma- ... | 1977 | 87296 |
| [fundamental studies of t4 value by tetra tab kit (author's transl)]. | 1979 | 87004 | |
| euthyroid high total t4, normal t3 syndrome. | 1979 | 86913 | |
| euthyroid high total t4, normal t3 syndrome. | 1979 | 86912 | |
| low dose lithium-carbimazole in the treatment of thyrotoxicosis. | fifteen patients with thyrotoxicosis were treated with low dose sustained release lithium carbonate 400 mg, combined with carbimazole 40 mg daily, and the therapeutic response was followed over a two week period. this response was compared with that obtained in a similar group of patient treated with carbimazole alone. li-carbimazole treatment brought about a fall in the mean total serum t4 of 57.4% compared with a drop of 32.8% in patients treated with carbimazole alone. the mean serum t3 fell ... | 1978 | 86350 |
| the binding of thyroxine and tri-iodothyronine to plasma proteins in the chicken at the physiological ph. | amounts of 125i-labelled thyroxine (t4) and triiodothyronine (t3), representing approximately 50 per cent of the plasma concentration, were incubated with chicken plasma or serum, the proteins were separated by polyacrylamide gel electrophoresis at ph 7.4 and the distribution of the hormones determined. seventy to 75 per cent of t4 migrated with albumin, about 10 per cent with the alpha-globulin and most of the remainder with a pre-albumin fraction. the percentage attached to the pre-albumin ten ... | 1978 | 86196 |
| raised total thyroxine and free thyroxine index but normal free thyroxine. a serum abnormality due to inherited increased affinity of iodothyronines for serum binding protein. | 2 people from different families had high levels of serum-thyroxine (t4) and a high free t4 (ft4) index but a normal serum triiodothyronine (t3) and serum-reverse-t3 (rt3). the abnormal serum thyroid hormone profile appeared to be inherited in an autosomal dominant manner. serum-ft4 in affected relatives was normal. the increases in serum-t4 and ft4 index are explained on the basis of an observed increase in affinity of t4 for thyroxine-binding globulin, thyroxine-binding prealbumin, and albumin ... | 1979 | 85873 |
| the effects of thyroxine and climatic factors on colostral gammaglobulin absorption in newborn calves. | observations of 68 friesian and holstein x friesian calves in a single herd with low neonatal mortality gave the following results: --the calves which will suffer from diarrhoea but survive were in a hyperthyroid state (high levels of hormonal iodine, t3 and free thyroxine index) compared with the healthy animals. --the concentration of plasma globulins, after colostrum intake was lower in diarrhoeic subjects calves than in the healthy ones. --for the whole group of animals, plasma hormonal iodi ... | 1978 | 85426 |
| structural changes during the transformation of bacteriophage t4 polyheads: characterization of the initial and final states by freeze-drying and shadowing fab-fragment-labelled preparations. | 1978 | 84876 | |
| studies on the mechanism of goitrogenic action of diphenylthiohydantoin. | diphenylthiohydantoin (dpth) is a potent goitrogenic compound and produces goiters in rats. like methimazole, dpth depresses plasma t4 and t3 concentrations and elevates plasma t4 and t3 concentrations and elevates plasma tsh concentration. unlike methimazole, however, dpth does not suppress thyroidal radioiodine uptake and thyroid hormone synthesis, although the monoiodotyrosine to diiodotyrosine ration is elevated by dpth. dpth does not inhibit thyroidal radioiodine release or augment the degr ... | 1978 | 84751 |
| the role of termination factor rho in the development of bacteriophage t4 [proceedings]. | 1978 | 84604 | |
| t3/t4 ratio in thyroid disease. | 1979 | 84114 | |
| thyroid and obesity: survey of some function tests in a large obese population. | tests of thyroid function in 493 obese patients were compared with thyroid function in 3076 non-obese patients. no differences in 131i uptake by the thyroid were observed at 6 h or 24 h; the frequency distribution was gaussian or normal in both populations; the frequencies of normal, high or low t3 and t4 values in the two populations were likewise comparable. further, no correlation was found in the obese subjects between 131i uptake (6 h and 24 h), t3, t4 and overweight; on the other hand, the ... | 1978 | 82549 |
| t3/t4 ratio in thyroid disease. | 1978 | 82076 | |
| indirect methods of assessing thyroid function. protein-bound iodine and thyroxine by column chromatography, a 1976 cap survey. | an assessment of the infrequently performed protein-bound iodine determinations (pbi) and thyroxine (t4) determinations by column chromatography is presented after analysis of data contributed by participants in the 1976 college of american pathologists chemistry survey programs. the two technics yield comparable mean concentrations, but there is considerable interlaboratory variance within method groups, especially among laboratories performing column chromatographic t4 iodine assays. | 1978 | 81610 |
| anti-thyroxine and anti-triiodothyronine antibodies in three cases of hashimotos thyroiditis. | antibodies against thyroxine (t4) and/or triiodothyronine (t3) were detected in 3 patients with hashimoto's thyroiditis. one of the patients had both anti-t4 and anti-t3 antibodies and the other 2 patients had only anti-t3 antibody. serum t4 or t3 antibodies and the other 2 patients had only anti-t3 antibody. serum t4 or t3 values measured by the single antibody radioimmunoassay (ria), were low or nil in these patients. one patient was mildly hypothyroid. the other 2 patients were clinically eut ... | 1978 | 81582 |
| [serum levels of t3 and t4 in hyperthyroidism during the administration of antithyroid drugs (author's transl)]. | 1978 | 80813 | |
| [maintenance of anti-streptococcal activity of haptoglobins after addition of hemoglobin]. | the antibody-like activity of haptoglobin types hp 2-2 and hp 2-1 for streptococci having the t4 antigen is not reduced by saturation with hemoglobin. | 1978 | 80363 |
| differentiation of thyrotoxicosis induced by thyroid destruction from graves' disease. | thyroid function was tested in untreated patients with graves' disease or thyrotoxic subacute thyroiditis, and in patients with autoimmune thyroiditis who showed postpartum or spontaneous transient thyrotoxicosis. the serum triiodothyronine/thyroxine ratio (t3/t4) was greater than 20 ng/microgram in graves' disease but less than 20 in all patients with subacute thyroiditis and 9 of 11 patients with autoimmune thyroiditis. thus, like radioactive iodine uptake, the serum t3/t4 ratio is useful for ... | 1978 | 79711 |
| [triiodothyronine, reverse-triiodothyronine, thyroxine, resin-triiodothyronine-uptake and protein bound jodide in the fluid of thyroid cysts (author's transl)]. | t3, rt3, t4, pbi and the saturation of t3-t4-binding proteins in yellow and brown cyst fluids of nontoxic goiters differ from the values in sera. in the brown cyst fluids, resulting from a hemorrhage, t3, rt3, t4, pbi and t3 u are significantly higher than in sera and no correlation could be found with the values in sera. in the yellow cyst fluids t3 and t3 u are significantly higher then in sera, t4 is lower, pbi and rt3 do not differ from the values in sera. only t3 and rt3 are not correlated. ... | 1978 | 79671 |
| thyroid hormones homeostasis and tsh in autonomic thyroid nodule. | thirty patients with autonomic thyroid nodules were studied. thyroid scintigram, iodine uptake at 2 and 24 hrs, pbi, total thyroxine, serum t3(ria), basal tsh and 30 minutes after trh administration were performed. a lack of concordance was found between the clinical signs and the laboratory data. according to the data obtained the patients were grouped into 3 categories: having 1) autonomic thyroid nodules with normal pbi, t4t, t3 values and absent or diminished tsh response to trh; 2) autonomi ... | 1978 | 79214 |
| closer correlation between serum triiodothyronine and basal metabolic rate during antithyroid drug treatment in patients with graves' disease. | the correlations between serum triidothyronine (t3), thyroxine (t4), 131i-triiodothyronine resin sponge uptake (rt3u) or free thyroxine index (t7) and the basal metabolic rate (bmr) during antithyroid drug treatment in 86 patients with graves' disease were investigated. although serum t3, t4, rt3u and t7 during therapy with mmi showed significant positive correlations with bmr, the coefficient of correlation (r = 0.6088, p less than 0.001) between t3 and bmr was the highest of all. while the nor ... | 1978 | 78844 |
| thyroid function in patients undergoing maintenance hemodialysis: unexplained low serum thyroxine concentration. | thyroid function was studied in 55 patients undergoing maintenance hemodialysis who were all judged to be clinically euthyroid. the dialysis patients, in comparison to normal control subjects, had significantly lower mean values for serum t4 (4.0 +/- 1.4 [sd] microgram/dl versus 7.9 +/- 1.5 microgram/dl, p less than 0.001), t3 (118 +/- 31 ng/dl versus 147 +/- 28 ng/dl, p less than 0.001), free t4 measured by equilibrium dialysis (1.22 +/- 0.38 ng/dl versus 2.15 +/- 0.67 ng/dl, p less than 0.001) ... | 1978 | 78430 |
| specificity of helper t cells for different antigens. | balb/c nude mice have been injected with 10(6) congenic thymus cells, a number which allows some, but not all mice to respond to any particular t-dependent antigen. these mice have been tested for their ability to respond to three bacteriophages, t4, t7 and phix, sheep and horse erythrocytes, and alloantigens of c3h and c57bl/6 mice. the number of mice able to respond to each of these antigens was of the same order of magnitude. sheep and horse erythrocytes showed cross-reactivity at the t cell ... | 1978 | 76566 |
| late components of the visual evoked potential to search in short-term memory. | the present paper investigated the changes in the morphology of the vep as a function of the amount of search in short-term memory. the task required that the subject responds with a "yes" or "no", depending on whether a test digit has been part of a set of digits he had just seen. six sizes of sets were used, 1, 3, 5, 7, 9 and 11. eeg was recorded from c3, c4, t3, t4, cz, pz and oz, and sampled every 4 msec to obtain vep to the test digit. two late components were found to increase in latency w ... | 1978 | 75088 |
| effect of pregnancy on thyroxine binding globulin (tbg) in partial tbg deficiency. | an unusual opportunity was afforded to study the effect of endogenous increase in estrogen on thyroxine binding globulin (tbg) throughout pregnancy in a partially tbg-deficient female who conceived subsequent to initial examination. tbg binding of 125i-thyroxine (t4) before and up to four months of pregnancy was low in comparison to normal. starting from six months and up to the end of pregnancy, tbg activity showed a definite increase although still below normal. tbg binding capacity increased ... | 1977 | 74952 |
| [relationships between streptococcus pyogenes t4-antigens and haptoglobin types (author's transl)]. | some strains of beta-haemolytic streptococci were agglutinated with high titers (1:200-1:6400) by human sera of the haptoglobin types 2-2 and 2-1. no agglutination or with low titers (up to 1:20) was observed with sera of the haptoglobin type 1-1. this reactivity depends from the contents of streptococcus pyogenes t-antigens of the t-complex 4,24... this t4-antigen is present in group a streptococci (strep. pyogenes) of the types 4, 24, 26, 28, 29, 46, 48 and 60 but it may be present also in som ... | 1977 | 74924 |
| [comparison between the ria-t4 and the t4 (sebnitz) tests]. | 1977 | 74134 | |
| reduced active thyroid hormone levels in acute illness. | in acute and subacute disease the active thyroid hormones, triiodothyronine (t3) and tetraiodothyroacetic acid (tetrac), are decreased while serum-thyroxine (t4) levels tend to be slightly reduced. conversely, the inactive metabolite, reverse triiodothyronine (reverse t3), is increased indicating a diversion of t4 metabolism from an activating to an inactivating pathway. with convalescence the serum levels of t3, tetrac, and t4 recover while reverse t3 decreases to normal. these changes occur wi ... | 1976 | 73636 |
| effects of total fasting in obese women. i. response of the thyroid. | the values of serum t4, t3, t4/t3, rt3u, ft4i, pbi, atr, tsh, 132i uptake and antibodies against thyreoglobulin were estimated in non-obese, healthy women and in obese women with a stabile body weight on total fasting of 14 days. obesity with no dietary restriction compared with normal controls was accompanied by a tendency to higher serum levels of t4 and t3 and prolonged atr. other indicators of thyroid function remained unchanged. total fasting led to a decrease of serum t3 and to an increase ... | 1977 | 72659 |
| serum thyrotropin response to thyrotropin-releasing hormone and free thyroid hormone indices in patients with familial thyroxine-binding globulin deficiency. | the response in serum thyrotropin (tsh) to synthetic thyrotropin-releasing hormone (trh) as well as serum free thyroxine index (ft4i) and free triiodothyronine index (ft3i) was investigated in six patients with familial thyroxine-binding-globulin (tbg) deficiency. the total serum thyroxine (t4) and triiodothyronine (t3) concentrations were significantly decreased, compared with those of normal subjects (3.4 +/- 0.9 microgram/dl, mean +/- sd. vs. 9.0 +/- 1.5 microgram/dl, p less than 0.01 and 87 ... | 1977 | 72658 |
| protamine messenger rna from rainbow trout testis contains the nucleotide sequence a-a-u-a-a-a in an untranslated region. | full-length, complementary dnas were prepared to rainbow trout protamine mrna using reverse transcriptase and were labelled during synthesis by the replacement of datp by [alpha32p]datp or dttp by [alpha32p]dttp. the 32p-labelled protamine complementary dnas were digested with t4 endonuclease iv. fragments from the digests were separated in two dimensions, and those discrete fragments which could be identified from both the a-labelled and t-labelled complementary dnas were subjected to sequence ... | 1977 | 72566 |
| blood levels of cyclic amp, thyroxine, uric acid, certain metabolites and electrolytes under heat-stress and dehydration in the pigeon. | the effect of heat stress and dehydration on certain blood parameters were studied in the pigeon. pigeons exposed to heat-stress and dehydration showed higher haematocrit values. serum cyclic amp levels, both with and without corrections made for difference in haematocrit, showed a more than two-fold increase in heat-stressed and dehydrated pigeons. serum triglyceride level (before and after correction for haematocrit difference) in the experimental birds dropped to less than half that in the co ... | 1977 | 72533 |
| [changes in serum t3, t4 and tsh before and after the t3-suppression test in patients treated for graves' disease (author's transl)]. | 1977 | 72007 | |
| the clinical value of serum triiodothyronine, thyroxine and thyrotropin estimations during medical antithyroid treatment. | the relation between clinical status and serial determinations of serum t3, serum t4 and serum tsh has been evaluated in the early phase of medical antithyroid treatment in 12 unselected hyperthyroid patients, and in 19 patients who later during treatment accidentally developed low serum t4 values. determination of both serum t3 and serum t4 was found necessary to avoid undertreatment. two patients with signs of hypothyroidism in the early phase developed low serum t4, while serum t3 and serum t ... | 1977 | 70965 |
| evidence for dopaminergic control of thyrotrophin secretion in man. | after administration of the dopamine-receptor-blocking drug, metoclopramide (10 mg orally), there is significant release of thyrotrophin (t.s.h.) in hypothyroid patients which is not evident in euthyroid subjects. this is not due to spontaneous fluctuation in basal t.s.h. levels, and it indicates inhibitory dopaminergic control of t.s.h. release in man. the lack of significant t.s.h. release in euthyroid subjects may be due to the inhibitory effects of normal circulating levels of t3 and t4 on t ... | 1977 | 70641 |
| single-drug chemotherapy of bladder cancer with adriamycin, vm-26 or bleomycin. a phase ii multicentric, co-operative study. | single-drug chemotherapy was employed in a multicentric co-operative trial. adriamycin was given to 18 patients, vm-26 to 30 and bleomycin to 33. almost all patients were suffering from a t3 or t4 bladder cancer with known metastases in almost 40% of cases. the vast majority of patients had already received previous treatment either chemotherapy, surgery of irradiation. complete regression was obtained in 5% of cases; partial objective regression in 11.1% of patients treated with adriamycin, 26. ... | 1976 | 70352 |
| spectrum of thyroid function in patient's remaining in remission after antithyroid drug therapy for thyrotoxicosis. | thyroid function was assessed in 110 patients who were in remission for a period of 7-6 +/- 0-6 years (mean +/- s.e.) (range 0-25--25 years) after the withdrawal of antithyroid drug therapy for thyrotoxicosis. on the basis of clinical examination and on the results of thyroid-function tests, the following group of patients were identified: (i) euthyroid with normal plasma-total thyroxine (t4) and triiodothyronine (t3) concentrations, but an absent or subnormal response of plasma-thyrotrophin (t. ... | 1977 | 69792 |
| diagnosis of hyperthyroidism when serum-thyroxine alone is raised. | 31 patients admitted to hospital with different non-thyroidal intercurrent diseases were found to have raised total serum-thyroxine (t4) and free t4 together with normal serum-triiodothyronine (t3) concentrations. at admission none was clinically hyperthyroid. patients were assigned to 3 groups according to clinical course and the laboratory findings. in the first group (14 patients) classic hyperthyroidism developed after recovery from the intercurrent disease. 11 out of these 14 patients had r ... | 1977 | 69145 |
| combined therapy of oral cancer bleomycin and radiation: a clinical trial. | a concurrent randomised controlled clinical trial to evaluate a combination of bleomycin and radiation as against radiation only in the treatment of advanced oral cancer has been conducted at the cancer institute, madras, since 1971. all t3 and t4 previously untreated oral squamous cell carcinomas with n0, n1 and n2 regional nodes, or n3 nodes confined to the submandibular region, without systemic metastases or gross infiltration of the temporal and infratemporal fossa producing total trismus, a ... | 1977 | 68844 |
| sporadic non-toxic goitre. a long-term follow-up of 36 patients. | thirty-six patients with non-toxic goitre were reviewed after a mean period of 13 years. initially 19 patients were iodine deficient (group i) and 17 had normal plasma inorganic iodine (group ii). in general the iodine deficient patients had larger goitres, developed more complications (26% became hyperthyroid, hypothyroid or required partial thyroidectomy), and required more treatment. there were marked changes in thyroid function tests. in both groups thyroid uptake fell and pii rose though th ... | 1977 | 68654 |
| effect of insulin-induced hypoglycemia on the level of serum tsh, total t4, free t4 and t3. | 1977 | 68540 | |
| t4 radioimmunoassay with ion-exchange resin separation. | 1977 | 68243 | |
| post-partum transient thyrotoxicosis with painless thyroiditis. | 5 patients presented with transient thyrotoxicosis and painless thyroiditis in the post-partum period. thyrotoxicosis developed within 1-6 months of delivery. all had small non-tender goitres. initially, all patients had elevated values for thyroxine (t4), triiodothyronine (t3) uptake, and triiodothyronine by radioimmunoassay (t3[r.i.a.]). radioactive-iodine uptake (r.a.i.u.) was suppressed in all. in all patients, thyrotoxicosis resolved within 4 months; subsequent transient hypothyroidism occu ... | 1977 | 68224 |
| [effect of thyroidectomy on circulating thyroid hormones in dogs administered insulin]. | in the blood of intact dogs, insulin increases the labelled thyroid hormones (pbi) by about 30% and doubles the t3 level. in athyreotic insulin-administered dogs, the circulating t4 and t3 remain at more or less unvarying values, the plasma disappearance slope of radiothyroxine is not altered. such data suggest that without the thyroid gland, insulin has no action on the level of the blood thyroid hormones. | 1976 | 67881 |
| homocytotropic antibodies (ige) to neisseria gonorrhoeae in the rat and a cross-reactivity of heterologous gonococcal strains. | outbred wistar rats were immunised with a single intraperitoneal injection of a mixture of 30 mg of a1(oh)3 and 100microng of gonococcal zeolite antigen (za). ten days after immunisation, za prepared from t1 and t4 colonies of neisseria gonorrhoeae strain gc6 (gc6-t1 za and gc6-t4 za) were able to elicit a reaginic (ige) response which declined to low levels by 35 days. there was a significant amount of histamine release from the mast cells of actively-sensitised rats on challenge with a specifi ... | 1977 | 66964 |
| the inhibitory action of the pineal extract on trh. | the effects of a single dose and of 5 doses (5 days) of a bovine polypeptide pineal extract (pe) on the pituitary tsh reserves and on the blood level of thyroid hormones were studied on hypothyroid patients. the blood levels of pbi, total t4 (radiocompetitive), free t4, t3 and tsh (ria) in basal conditions and during the trh test (i.v. administration of 200 mug trh), in the presence and absence of the treatment with pe were determined. thirty minutes following i.m. administration of pe a decreas ... | 1977 | 66735 |
| [evaluation of the method of blood tyroxine determination with the aid of non-immunosorbents]. | tetralute 125i-column is a set for determination of the total thyroxin content in the serum; this is a valuable test for examination of the t4 content in the blood with the aid of radioactive isotopes. the method is simple, specific, sensitive and precise, and can be used both under laboratory and under clinical conditions. results of this test coordinate with the data of the protein-bound iodine study and the percentage of the t3 absorption. the work is based on determination of t4 in 2050 samp ... | 1976 | 66676 |
| t4 radioimmunoassay and thyroxine-binding globulin concentration. | 1977 | 66554 | |
| short and long term effects of radioiodine and antithyroid drugs on t4 binding proteins, free t4 and t3, during graves' disease therapy. | ninety five patients with graves' disease were studied before and at three months intervals after antithyroid drugs (atd) (31 cases) or radioiodine (64 cases) therapy until recovery. before treatment, the t4 maxima binding capacity of tbpa was significantly decreased 253.5 +/- 11.4 mug/100 ml)(mean + se) (control values: 287 +/- 10.4 mug/100 ml) (alpha = 0.04), especially in 53.7% of patients (m = 177 +/- 8 mug/100 ml). the mean of tbg (m = 20.7 +/- 0.9 mug/100 ml) was not different from euthyro ... | 1977 | 66177 |
| study of the pituitary-thyroid functions at high altitude in man. | the alterations in serum levels of t3, t4, tsh and tbg, tsh response to 100 mug iv trh, and urinary excretion of t3 and t4 were studied in 8 healthy men at sea level (sl), on days 1, 2, 4, 8 and 16 after arrival by air at high altitude (3,700 m, ha), and during days 5 to 7 after their return to sl. no significant alterations in serum levels of tsh and tbg or tsh response to trh were observed during exposure to ha or on return to sl. there was, however, an acute elevation in both serum total t3 a ... | 1977 | 65358 |
| [a case report of hashimoto's disease with anti-thyroxine autoantibody (author's transl)]. | in one case of untreated hashimoto's disease, serum thyroxine (t4) value by radioimmunoassay (ria) was significantly lower than that by competitive protein binding analysis (cpba). the discrepancy was found to be due to the presence of antithyroxine autoantibody in the serum. this phenomenon was considered to be of practical importance in interpreting the t4 value by ria in cases with autoimmune thyroid diseases. the patient was 59-year-old woman with a 30-year history of goiter. a diagnosis of ... | 1976 | 65300 |
| concentration of thyroxine-binding globulin: value of direct assay. | the concentration of thyroxine-binding globulin (tbg) in the serum can now be measured by direct assays that are simple and inexpensive. comparison of a direct measurement of tbg concentration with a widely used indirect method (thyopac-3) showed that the indirect method was inaccurate when tbg concentrations were high. this will result in an increase in the derived free thyroxine index (fti), so that euthyroid patients with a raised tbg concentration may be at risk of being labelled thyrotoxic. ... | 1977 | 65198 |
| rapid decrease in plasma-triiodothyronine during surgery and epidural analgesia independent of afferent neurogenic stimuli and of cortisol. | changes in circulating triiodothyronine (t3), thyroxine (t4), binding of thyroid hormones to plasma proteins (resin-t3 test), cortisol, and glucose were evaluated in sixteen patients undergoing abdominal hysterectomy. in eight of the patients afferent neurogenic impulses from the surgical area were blocked during and after operation by epidural analgesia. these patients were pain-free, and the normal stress-induced increase in cortisol and glucose was abolished. during epidural analgesia and gen ... | 1976 | 63806 |
| effects of small doses of l-thyroxine and triiodo-l-thyronine on pituitary lh content of thyroidectomized rats. | pituitary lh was studied by means of a specific radioimmunoassay (ria) in male rats at different time intervals after thyroidectomy (t), and in rats which were t at least 30 days before and were then treated with different doses of l-thyroxine or triiodo-l-thyronine. a decrease in the pituitary lh of the t animals, with respect to the intact age-paired controls, was demonstrable from 13 days after the operation, when total pituitary lh content was taken into consideration, or from 5 days after t ... | 1976 | 63208 |
| [malignant disease of the paranasal sinuses (author's transl)]. | during the period 1931 to 1974 167 men and 97 women with tumours of the maxilla or of the paranasal sinuses were treated at the department of radiotherapy and oncology, lainz hospital. the peak incidence is found in the age group 51 to 70 years. the survival rate is determined by the extent of spread of the tumour. cases in which the malignant process is still localized in the mucosa, without infiltration of the adjacent bony structures, have a good prognosis and so have the early cases of all t ... | 1976 | 63183 |
| [age dependent morphokinetics of the thyroid gland. histochemical, morphometric, light-microscopical and functional investigations (author's transl)]. | the aim of the animal experiments was to investigate the question of the age dependence of the morphokinetic reactions of the thyroid gland under standardised conditions. through the administration of pharmaceutical substances, it was possible to produce defined functional states of the thyroid in the various age groups. materials and methods 700 albino rats of the chbb: thom (spf) strain, age 0 days (newborn) to 110 weeks, were used in the investigations. the animals were divided into 4 groups ... | 1976 | 62467 |
| preclinical hyperthyroidism in multinodular goiter. | the thyrotropin (tsh) response to thyrotropin-releasing hormone(trh) (200 mug iv) was determined in 80 surgical patients with nontoxic multinodular goiter. the tsh reserve was normal in multinodular goiter. the tsh reserve was normal in 55 and elavated in 8 patients. no tsh response to trh (deltatsh less than or equal to 1 muu/ml) was detectable in 17 patients (21%). individual and mean serum t4, ft4i and serum t3 values did not differ from normal in 13 of the trh unresponsive patients; in 4 pat ... | 1976 | 61970 |
| hct and thyroid function in molar pregnancy. | hct, tsh, t3, t4, pbi, t3-rsu, tbg binding capacity, bmr and thyroid uptake of radioiodine were measured simultaneously on the volunteers with hydatidiform mole and normal pregnancy. trh stimulation tests were performed on the two groups. the serum hct levels were higher in association with molar pregnancy than in normal pregnancy. tsh levels were within the nonpregnant range in the two groups. t3, t4, pbi, etr, bmr and thyroid uptake of radioiodine suggested thyroid hyperfunction in molar pregn ... | 1976 | 61702 |
| temporary hypothyroidism after surgical treatment of thyrotoxicosis. | mild clinical hypothyroidism associated with low levels of serum total thyroxine (t4) and tri-iodothyronine (t3) and raised levels of serum thyroid-stimulating hormone (t.s.h.) has been observed in 14 of 40 patients (35%) in the early months after a subtotal thyroidectomy for thyrotoxicosis under cover of propranolol. in 10 of the patients, however, the hypothyroidism was temporary and at 6 months after operation the thyroid hormone levels were normal and the serum t.s.h. levels had fallen. in 4 ... | 1976 | 61495 |
| inhibition of specific binding of dnp (dinitrophenyl) determinant to lymphoid-cell receptors by related and unrelated compounds : quantitative studies in vitro. | the effect of related and unrelated compounds on the specific binding of dinitrophenyl-coupled bacteriophage (dnp-t4) to lymphoid cell receptors has been examined and compared with the effect on the neutralization of dnp-t4 by anti-dnp serum. spleen cells and sera from balb/c mice immunized with dnp-bovine serum albumin were used. the binding of dnp-t4 to the cells was inhibited by dnp-eacp, di-dnp-lys, dnp-tyr, dnp-p(ornith) and dnp-bsa (among the dnp-derivatives tested), tnp-bsa, ars-p(tyr) an ... | 1976 | 60907 |
| familial partial target organ resistance to thyroid hormones. | a 30-year old woman with a history of recurrent goiter, who had undergone two partial thyroidectomies, is described. she presented with tachycardia, nervousness and a fine tremor of the fingers. initially, she had normal serum thyroid hormone levels: thyroxine (t4 (d)) 11.6 mug/100 ml, triiodothyronine (t3) 138 ng/100ml, normal levels of binding proteins and a very high serum thyrotropin (tsh), 98 muu/ml. during follow-up t4 (d) increased to 17.2 mug/100 ml, t3 increased to 277 ng/100 ml, while ... | 1976 | 60346 |
| humoral immune responses in rana catesbiana frogs and tadpoles. | rana catesbiana adult frogs and tadpoles were immunized with the bacteriophage f2, 0x-174, and t4 and the haptens 2,4 dinitrophenyl (dnp) and fluorescein (ftc). the haptens were conjugated with bovine serum albumin (bsa), bovine gamma globulin (bgg), or horsehoe crab hemocyanin (hycn). sera were obtained from immunized animals at invervals up to six months after immunization. the antibody activities were measured by bacteriophage neutralization techniques. sucrose density gradients were used to ... | 1976 | 59790 |
| pituitary-thyroid regulation in euthyroid patients with graves' disease previously treated with antithyroid drugs. | to understand why some patients with hyperthyroidism due to graves' disease remain euthyroid after a course of antithyroid drug therapy, pituitary-thyroid regulation was studied in 20 such patients who had remained well for six months or longer after the withdrawal of antithyroid drugs. only patients who were clinically euthyroid and had normal serum thyroxine (t4), triiodothyronine (t3), and thyrotropin (tsh) concentrations were studied. serum tsh responses to thyrotropin-releasing hormone (trh ... | 1976 | 59733 |
| placento-thyroidal relationship in normal pregnancy. | estimations of serum hct, htsh, t4, t3, pbi, etr, triosorb, tbg-binding capacity, bmr and urinary total estrogen were made simultaneously in 160 women in normal pregnancy. trh stimulation tests were made in 20 cases in each trimester of pregnancy. hct was detectable even in early pregnancy, tending to increase gradually toward the terminal stage of pregnancy as serum thyrotrophin bioactivity showed. on the other hand, serum tsh level measured by radio-immunoassay remained essentially the same th ... | 1976 | 59514 |
| [triiodothyronine thyrotoxicosis in nodular toxic goiter]. | serum protein-bound iodine (pbi), total blood thyrotoxin (t4), triiodthyronine (t3), coefficient of thyrotoxin efficacy (cte), serum thyrotoxin-binding capacity (tbc) or some of these indices were determined in 44 patients with nodular toxic goiter with thyrotoxemia. an increase in t3 level was revealed in 27 of 35 of the patients; t3-thyrotoxicosis was diagnosed in 18 of these in whom an increase of the t3 level was combined with normal t4 or normal cte content and an unchanged tbc. the symptom ... | 1976 | 59358 |
| effect of a single dose of dexamethasone on serum concentrations of thyroid hormones. | in ten euthyroid subjects, in whom endogenous thyroid-stimulating hormone (t.s.h.) production was suppressed by oral thyroxine (t4), a single dose of dexamethasone resulted in reduced serum-3,3'5-triidothyronine (t3) concentration and raised serum-3,3',5'-triiodothyronine (reverse t3 or rt3) concentration after 24 h. these changes were not related to changes in free hormones or binding proteins. adrenal glucocorticoids may have a pathophysiological role in modulating the peripheral metabolism of ... | 1976 | 59147 |
| hemodynamics of hyperthyroidism. the effects of autonomic nervous blocking and anti-thyroid drug treatment. | this work was intended to analyze the sympathetic and parasympathetic factors affecting the hemodynamics of hyperthyroidism. seven patients with hyperthyroidism, diagnosed based on the determinations of bmr, 131i-uptake, t3-resin sponge uptake (t3-rsu), and serum level of thyroxine (t4) were subjected to the study. the hemo-dynamic estimation was done (1) at rest, (2) after vagus blocking by the injection of 0.04 mg/kg b.wt. atropine and 0.2 mg/kg b.wt. propranolol before (hyperthyroid state=h) ... | 1976 | 59000 |
| an improved quantitative plaque assay for lymphocytes bearing antigen-specific cell receptors. | an improved method for the determination of the number of lymphoid cells bearing antigen-specific receptors is described. the method is based on the use of hapten-coupled bacteriophage (dinitrophenyl-t4) and detection of lytic plaques formed by the action of dnp-t4 on a target e. coli strain. the method is highly specific (up to 90% specific binding) and can be adapted for use with other antigenic determinants chemically attached to an active bacteriophage. | 1976 | 58942 |
| isolation and characterization of t-even ghost-tolerant mutants of escherichia coli. | mutants of escherichia coli tolerant to the ghosts of t-even phages (t2, t4, and t6) have been isolated from a strain supersensitive to t6 phage. first, t6 supersensitive mutants were isolated from mutagenized e. coli w2252 by replica plating to t6 phage-overlaid agar. one of them, strain nm101, was mutagenized again, grown, and then plated with a high multiplicity of t4 and t6 ghosts. surviving cells were checked for tolerance to ghosts and adsorption of phages. one such ghost-tolerant mutant, ... | 1976 | 58859 |
| delayed response of ankle jerk time changes in decreasing thyroid function in comparison with the serum cholesterol changes. | 1. serum cholesterol, pbi and ankle jerk time (ajt) were measured simultaneously in a group of not yet treated patients, where a relatively steady state of thyroid function was expected, and in a treated group, where change to lower thyroid function was supposed (thyrostatic drugs, near total thyroidectomy, radioablation of thyroid). 2. serum cholesterol correlated poorly with pbi (r = --0,4427), better correlation was achieved after logarithmic transformation of pbi values (r = --0,6839). 3. re ... | 1975 | 58781 |
| evaluation of three thyroid-function screening tests for detecting neonatal hypothyroidism. | three thyroid-function detection methods were evaluated concomitantly for possible application as routine screening tests for the early diagnosis of neonatal hypothyroidism. dried capillary-blood thyroxine (t4) was measured on eluted filter-paper discs for 9734 3-5-day old neonates. serum t4 and thyroid-stimulating hormone (t.s.h.) assays from cord blood were studied as alternative screening tests on 4911 and 3733 infants, respectively. to avoid false-negative results, neonatal blood-t4 and cord ... | 1976 | 58257 |
| immunoassay of human tsh using dried blood samples. | a sensitive, semi-quantitative radioimmunoassay method to screen for elevations of tsh concentration in blood is described. the method requires two 0.32 cm dots of dried blood-impregnated filter paper (equivalent to 3 mul plasma) and a 3-day incubation. separation of bound and free is obtained using polyethylene glycol. the method can recognize tsh concentrations as low as 22 muu/ml using a highly sensitive antiserum developed by one of us (afp). tsh in dried cord and newborn blood from 4 infant ... | 1976 | 57965 |
| radioimmunoassay for serum thyroxine-binding globulin: results in normal subjects and in patients with hepatocellular carcinoma. | serum thyroxine-binding globulin (tbg) was measured by radioimmunoassay. the human tbg used in this study was purified by affinity, anion-exchange, and gel filtration chromatography. the serum tbg concentration in 98 euthyroid normals was 1.48 +/- 0.46 mg/100 ml (mean +/- sd), which is one-half that previously reported using a similar method. the level in females (1.66 +/- 0.56) was significantly higher than that in males (1.37 +/- 0.37). comparison of the serum tbg level and the maximum binding ... | 1976 | 57964 |
| total and free triiodothyronine and thyroid-binding globulin concentration in elderly human persons. | total thyroxine (tt4) and triiodothyronine (tt3) were found to be low in healthy elderly subjects with a preferential decrease of triiodothyronine. in order to determine the importance of these findings 22 healthy elderly subjects were examined. free triiodothyronine (ft3), thyroid binding globulin (tbg) concentration and basal thyroid stimulating hormone (tsh) were measured by radioimmunoassay. liver enzymes, cholesterol and total protein concentration were also assayed. tbg was significantly i ... | 1976 | 57057 |
| [experiences in the determination of thyroxine iodine in serum in various functional conditions of the thyroid gland]. | a report is given on the method of the thyroxine iodine determination in the serum. of 213 patients the result of the thyroxine iodine determination was compared with the clinically and radiologically established functional condition of the thyroid gland. the findings are discussed. similar results were also reported of other in-vitro-tests (t3-test, t4-test, bej and pbj). according to our experiences we consider the thyroxine iodine determination in the serum siutable as screening test which - ... | 1975 | 56823 |
| metabolism of thyroxine-binding globulin in man. abnormal rate of synthesis in inherited thyroxine-binding globulin deficiency and excess. | it has been previously suggested that inherited thyroxine-binding globulin (tbg) abnormalities in man may be due to mutations at a single x-chromosome-linked locus controlling tbg synthesis. however, abnormalities in tbg degradation have not been excluded. the availability of purified human tbg and its successful labeling with radioiodide allowed us to examine such possibility. human tbg was purified by affinity chromatography, labeled under sterile conditions with 131i or 125i,, and mixed with ... | 1976 | 56342 |
| thyrotoxicosis with painless thyroiditis. | four women and one man with painless subacute thyroiditis presented with hypermetabolic signs and symptoms. thyroxine (t4) and triiodothyronine (t3) resin uptakes (t3r) were increased but the 24 hour radioactive iodine (rai) uptakes were less than 1 per cent. surreptitious use of thyroid hormone was excluded. the thyroid was enlarged in one patient and nontender in all. exophthalmos was absent. the protein-bound iodine level was 1.1 to 9.5 mug/dl greater than the t4 level. the sedimentation rate ... | 1976 | 56130 |
| a transient rise of hormone secretion: a response of the stimulated rat thyroid gland to small increments of iodide supply. | small doses of iodide (2 times 3.2 mug at 12 h interval), below those capable of inducing wolff-chaikoff effect, were injected into rats kept on a moderately low iodine diet. by means of a 125i equilibration technique as well as by direct measurement of cold t4, it was demonstrated that the level of circulating pb125i (representing iodothyronines as confirmed by column chromatography) increased by a mean of 40% within 24 h following the first iodide injection. the serum tsh concentration (measur ... | 1976 | 56115 |
| [the effect of contrast media containing iodine on selected in vitro thyroid test procedures (author's transl)]. | the effect of 6 commonly used contrast media on the results of 3 different methods for determination of thyroid hormone concentration in the serum is examined in vivo. t4 determination by column chromatography proved to be very liable to distortion for contrast media. with some contrast media the res-o-mat-etr test proved unreliable. t4 determination by means of protein binding analysis is not affected by contrast media in the direction of false raised values. | 1976 | 55963 |
| [immunogenic properties of dna from e. coli and t4 phage, containing 5-bromouracil]. | 5-budr incorporated into e. coli or t4 phage dnas is an immunogenic determinant. immunodominance of 5-budr is determined by the chemical structure of dna molecule into which it is incorporated. in e. coli dna, 5-budr inhibits immunogenic activity of all other bases. one can conclude that in this dna 5-budr is the dominant antigenic determinant. in t4 dna, 5-budr acts as an additional antigenic determinant. anti-5-budr-t4-dna contains antibodies to 5-budr and glucosylated 5-hmc. | 1975 | 55955 |
| resin hemoperfusion: a method of removing circulating thyroid hormones. | the ability of an extracorporeal hemoperfusion system employing neutral amberlite resin to bind thyroid hormone and to decrease circulating levels of triiodothyronine (t3), thyroxine (t4), and free thyroxine (ft4) was evaluated in dogs made thyrotoxic by the intramuscular administration of thyroid hormone. since the resin column and tubing were charged with saline, the effects of hemodilution from this source on serum t3 and t4 was assessed by control perfusion through a column which did not con ... | 1976 | 55416 |
| the thyroxine-binding properties of rat and rabbit serum proteins. | the thyroxine (t4) binding properties of rat and rabbit serum proteins were studied using a gel equilibration technique, gel filtration and polyacrylamide gel electrophoresis. in both species two different t4 binding molecules were identified in whole serum and in cohn fraction v preparations. only one of these binding species demonstrated the characteristics of specific binding, i.e., high affinity for the hormone and binding site saturability. the mean (+/- sd) apparent association constants ( ... | 1976 | 55359 |
| [diagnostic staged program in thyroid diseases]. | after some physiological principal remarks the modern possibilities of the in-vitro-diagnostics specific for the thyroid gland are briefly explained. the essential factors of disturbance which are necessary for the avoidance of false interpretations are mentioned. from the sequence of the description (bej, t4-test, t3-test, ft4-index, ria-t3 and ria-tsh) results the diagnostic step programme proposed by us, by means of which the majority of the functional disturbances of the thyroid gland existi ... | 1975 | 55003 |
| serum triiodothyronine and reverse triiodothyronine concentrations after surgical operation. | serum-triiodothyronine (t3) concentrations fell rapidly after surgery in six out of seven initially euthyroid patients. simultaneous increases in reverse triiodothyronine (rt3) concentrations suggested that the peripheral monodeiodination of thyroxine (t4) proceeds by an alternative pathway in the postoperative period. | 1975 | 54799 |
| thyroidal triiodothyronine and thyroxine in graves' disease: correlation with presurgical treatment, thyroid status, and iodine content. | to evaluate the potential contribution of thyroidal secretion to the relative excess of triiodothyronine (t3) production in hyperthyroidism and to investigate the effects of treatment, iodine (127i), t3 and thyroxine (t4) were measured in digests of thyroid tissue obtained at surgery from 13 patients with graves' disease. in 11 normal human thyroid glands, 127i content was 630 +/- 60 (all values mean +/- se in mug/ wet weight) t4, 254 +/- 39 and t3 21 +/-3. the t4i was 26 +/- 3% of the total iod ... | 1975 | 54364 |
| [influence of hypo- and hyperthyroidism on the turnover rate of noradrenaline, dopamine and serotonin in various rat cerebral structures]. | the effect of chronic treatment with tyroxine (t4) or propylthiouracile (ptu) on the turnover of norepinephrine (ne), dopamine (da) and 5-hydroxytryptamine (5-ht) has been studied in various areas of the rat brain (brain stem, hypothalamus, striatum and "rest of the brain"). the turnover of ne and da was determined by the decay in endogenous levels after inhibition of tyrosine hydroxylase by alpha-methylparatyrosine and the turnover of 5-ht was evaluated by the initial accumulation of endogenous ... | 1975 | 54127 |
| value of routine serum-triiodothyronine estimation in diagnosis of thyrotoxicosis. | thyroid-stimulating hormone (t.s.h.), triiodothyronine (t3), and thyroxine (t4) concentrations were estimated on 432 blood specimens from patients with a provisional diagnosis of thyrotoxicosis. 59 patients had a raised serum t3 concentration with t.s.h. and t4 levels in the normal range. further information was obtained in 41 of these patients, and t3 toxicosis was diagnosed in 17 cases, thus providing a projected total of 24 patients with t3 toxicosis. in addition, there were 56 patients, with ... | 1975 | 53496 |
| triiodothyronine and thyroid-stimulating hormone in protein-calorie malnutrition in infants. | protein-calorie malnutrition (p.c.m.) in a group of 43 senegalese children aged eighteen to thirty months was characterised by a sharp fall in serum-triiodothyronine (t3) concentration to 25-3% of the mean value in healthy age-matched controls. this decrease in t3 was significantly (p less than 0-001) more pronounced in kwashiorkor of recent onset than in long-term p.c.m., a finding which suggests that impaired thyroxine (t4) monodeiodination in the liver was responsible for the fall in serum-t3 ... | 1975 | 53331 |
| a temporal component of the auditory evoked response. | we studied the 75-225 msec portion of the auditory evoked response (aer) in 32 normal adults at vertex (cz) and temporal (t3 and t4) placements referred to a balanced, noncephalic reference electrode using a monaural 1 msec click stimulus delivered every 4.7 sec at 60 db above threshold. the tape-recorded eeg was filtered at 1-25 c/sec, and 128 individual responses were summed, sampling every 0.5 msec for 250 msec post-stimulation. the cz aers showed the classic vertex response, a negative peak, ... | 1975 | 53139 |
| [proceedings: pituitary thyroid axis in subacute thyroiditis (author's transl)]. | we studied 10 patients with subacute thyroiditis. all had an increase in free thyroxine index, pbi, t4 and pbi/t4 ratio, an absence of thyroidal radioiodine uptake and no increase in plasma tsh after trh injection. exogenous tsh increased the uptake in 6/9 patients. the three patients who did not respond to tsh had higher pbi/t4 ratio than others. after treatment for one month there was either a normalization of laboratory tests either a subnormal thyroid function associated with an absence of r ... | 1975 | 53025 |
| [correlation studies of some thyroid function tests (author's transl)]. | the results of a thyroid test based on ion exchange and column chromatographic separation and of two radiochemical t4 and three t3 tests were carried out with commercially available reagent packs ready for use, and were compared with the pbi values found in the same serum sample in each case. this also tested the analytical precision of each method. a good correlation was found between the pbi and the t4 values, while the accuracy of the t3 tests was unsatisfactory. | 1975 | 52835 |
| determinants of the hierarchy of humoral immune responsiveness during ontogeny. | a model system of ontogeny was utilized to investigate the development of humoral immunity in both akr and balb/c mice. lethally irradiated adult mice were reconstituted with syngeneic fetal or neonatal liver. these mice were immunized at various times after reconstitution with a series of eight antigens: the bacteriophages f2, phix-174, and t4; the hapten carrier complexes 2,4 dinitrophenyl-bovine serum albumin and fluorescein-bovine serum albumin; and the small proteins: hen egg lysozyme, sper ... | 1975 | 52670 |
| [excessive peripheral conversion of thyroxine (t4) to triiodothyronine (t3) in the pathogenesis of t3-hyperthyroidism (author's transl)]. | in a 41-year-old woman and a 3-year-old girl, both of them with t3-thyrotoxicosis, serum levels of total and free t4 and t3 were measured serially during anti-thyroid drug treatment. attempts to substitute thyroxine during the antithyroid treatment had to be interrupted because the patients became hyperthyroid again with excessive increases in total and free serum t3, even when concentrations of total and free t4 were brought to subnormal levels. the increased conversion of administered thyroxin ... | 1975 | 52434 |
| thyroxine utilization rate in sucking pigs. | in 10 suckling pigs age 28--34 days, thyroxine utilization rate (tur) was determined by means of the isotope dilution procedure. for this purpose biological half-life of t4 was estimated during 96 h of blood sampling and serum t4 concentration was measured directly by a competitive protein-binding technique. high rate of the peripheral hormonal-iodine metabolism (from 10.3 +/- 0.6 to 21.2 +/- 1.2 mug t4/kg/day) was found in the one-month old pigs. tur value calculated for these pigs corresponds ... | 1975 | 52283 |