Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| evaluation of a photolabile derivative of 1,25-dihydroxyvitamin d3 as a photoaffinity probe for 1,25-dihydroxyvitamin-d3 receptor in chick intestinal cytosol. | we evaluated the viability of 1 alpha, 25-dihydroxyvitamin d3-3 beta-[n-(4-azido-2-nitrophenyl)glycinate] (1,25-(oh)2-d3-ang), an analog of 1 alpha, 25-dihydroxyvitamin d3 (1,25-(oh)2-d3) as a photoaffinity probe for 1,25-(oh)2-d3 receptor in chick intestinal cytosol. a competitive-binding assay revealed that chick intestinal cytosolic 1,25-(oh)2- d3 receptor bound to 1,25-(oh)2-d3-ang approximately 20-times less effectively than it did to 1,25-(oh)2-d3. irradiation of 1,25-(oh)2-d3- ang in the ... | 1985 | 2998355 |
| [surgery in the treatment of patients with small cell lung cancer]. | the data on surgical and combined treatment of 52 cases of small cell lung cancer are presented and the end results are evaluated. the findings on survival time make the case for surgery as a component of combined treatment of tumor. the best results were obtained in cases of stage i and ii tumor, absence of metastases into intrathoracic lymph nodes, tumor invasion limited to bronchopulmonary lymph nodes or the root of the lung, intermediate cell pattern of small cell lung cancer and surgery fol ... | 2010 | 2998088 |
| the biologic significance of the mixed lymphocyte kidney culture in humans. | the mixed lymphocyte kidney culture (mlkc) in humans has been studied in normal and abnormal clinical conditions. human renal cortical cells were extracted by collagenase treatment from the kidneys of "normal" heart-beating cadaver organ donors (n = 13), patients with end-stage renal disease (esrd) at pretransplant bilateral nephrectomy and splenectomy (n = 13), and from irreversibly rejected renal allografts at the time of graft nephrectomy (n = 5). proliferation of peripheral blood t lymphocyt ... | 1985 | 2996186 |
| receptors for epidermal growth factor in the rat uterus. | uterine membranes contain high affinity [dissociation constant (kd) = 0.36 nm], saturable binding sites for [125i]iodo-epidermal growth factor (egf). the binding of [125i] iodo-egf is specific since it is abolished by excess unlabeled egf but not by excess unlabeled insulin, fibroblast growth factor, or multiplication-stimulating activity. incubation of [125i] iodo-egf with uterine membranes, followed by chemical cross-linking with disuccinimidyl suberate and detergent extraction reveals a major ... | 1985 | 2988913 |
| inflammatory myopathies: part 2. | 1985 | 2988409 | |
| conditioned taste aversion suppresses induction of delayed-type hypersensitivity immune reactions. | conditioned taste aversion was induced in mice by pairing saccharin drinking with an intraperitoneal injection of lithium chloride, a toxic but nonimmunosuppressive drug. conditioned mice showed not only suppressed saccharin drinking but also a 75% reduction in the induction of delayed-type hypersensitivity immune responses to low doses of sheep erythrocytes. this effect was observed with doses of lithium chloride which had no effect of their own on immune functions. in addition, a reduction in ... | 1985 | 2987987 |
| herpes simplex virus and cytomegalovirus infections in burned patients. | herpesvirus infections are commonly seen in immunosuppressed patients and may account for considerable morbidity and some mortality. we prospectively studied 52 patients with severe burn injuries in order to determine the prevalence of viral infections in this group of patients. serologic testing was done each week to diagnose primary and reactivation infections. twenty-seven of 52 patients (52%) became infected with either herpes simplex virus (hsv) or cytomegalovirus (cmv) or both. hsv infecti ... | 1985 | 2981325 |
| restriction nuclease digestions driven to completion by escherichia coli rna polymerase and t4 gene 32 protein. | restriction enzyme digestions of large scale dna preparations often do not go to completion. this is due to product inhibition by the newly generated ends of the digested dna. the addition of exogenous proteins that bind tightly to the free ends of dna or to single-stranded dna will relieve this inhibition. we show that a considerable savings on restriction nucleases can be attained by the addition of rna polymerase or t4 gene 32 protein in stoichiometric amounts to the newly produced dna ends. | 1985 | 2981211 |
| cns-induced natriuresis during dopamine receptor blockade. further support for the existence of, at least, two separate natriuretic hormonal systems. | intracerebroventricular (icv) stimulation with hypertonic sodium chloride solutions has previously shown indications to stimulate the release of a blood-borne natriuretic factor. sodium excretion in this situation increases in the order of 10-20 times. acute isotonic volume expansion has shown to be a potent stimulus for endogenous release of the atrial natriuretic factor (anf). it has also been demonstrated that the natriuretic response to both volume expansion and exogenously applied anf can b ... | 1988 | 2976234 |
| activation of a cytosolic serine protein kinase by epidermal growth factor. | exposure of a-431 cells to epidermal growth factor (egf) results in a rapid enhancement (approximately 10-fold) of cytosolic serine protein kinase activity. the increase in serine kinase activity may be detected using a number of peptide and protein substrates. enhancement of kinase activity occurs within 1 min of exposure of the cells to egf and reaches a maximum in 5 min. similar results were obtained with a variety of cell lines. we have partially purified the egf-activated kinase from a-431 ... | 2010 | 2974035 |
| a multicentre open clinical trial of teicoplanin in infections caused by gram-positive bacteria. | a multicentre open trial of teicoplanin in 81 centres in nine european countries included 1431 cases: 531 female, 900 male; mean age 49.4 years, range 1-93 years. these were hospitalized patients most of whom had infections caused by staphylococcus aureus (816 isolates). of a total of 1427 gram-positive pathogens 280 (19.6%) were methicillin resistant. there were 536 skin and soft tissue infections, 263 septicaemias, 135 lower respiratory tract infections, 179 joint and bone infections and 83 en ... | 1988 | 2965133 |
| experimental echinococcus granulosus infection in mice: immunocytochemical analysis of lymphocyte populations in local lymphoid infections during early infection. | the influence of subcutaneous infection with protoscoleces of echinococcus granulosus on the distribution of lymphocyte subsets in draining lymph nodes has been evaluated by immunocytochemical labelling of lymphocyte surface antigens. these studies reveal marked expansion of paracortical thy-1+, lyt-1+ cells and moderate proliferation of surface immunoglobulin-bearing b-cells immediately after infection. the lyt-1+:lyt-2+ ratio decreases rapidly during the first 21 days post-infection and remain ... | 1987 | 2956563 |
| regeneration and repair of periodontal tissues. | 2010 | 2955107 | |
| differential effects of serotonin (5-ht1a and 5-ht2) agonists and antagonists on renin and corticosterone secretion. | the present study was designed to investigate the effect of distinct serotonin (5-ht1a and 5-ht2) agonists and antagonists on renin and corticosterone secretion. low doses of the selective 5-ht1a agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) (5.0-500.0 micrograms/kg, i.p.) and ipsapirone (tvx q 7821; 0.5-2.5 mg/kg, i.p.), and of the 5-hydroxytryptamine (5-ht) agonist mk-212 (2.0 mg/kg, i.p.), did not elevate plasma renin activity (pra) and concentration (prc) 30 min postinjection. ... | 1987 | 2952898 |
| differential effects of serotonin (5-ht1a and 5-ht2) agonists and antagonists on renin and corticosterone secretion. | the present study was designed to investigate the effect of distinct serotonin (5-ht1a and 5-ht2) agonists and antagonists on renin and corticosterone secretion. low doses of the selective 5-ht1a agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) (5.0-500.0 micrograms/kg, i.p.) and ipsapirone (tvx q 7821; 0.5-2.5 mg/kg, i.p.), and of the 5-hydroxytryptamine (5-ht) agonist mk-212 (2.0 mg/kg, i.p.), did not elevate plasma renin activity (pra) and concentration (prc) 30 min postinjection. ... | 1987 | 2952898 |
| the effect of six months continuous subcutaneous insulin infusion on kidney function and size in insulin-dependent diabetics. | glomerular filtration rate (gfr), renal plasma flow (rpf), kidney volume, and urinary albumin excretion rate were measured in 24 insulin-dependent diabetics, aged 29 +/- 7 years (mean +/- s.d.) of 8 +/- 4 years duration, randomly allocated to either continuous subcutaneous insulin infusion (csii) (n = 12) or unchanged conventional insulin treatment (cit) (n = 12). glomerular filtration rate, renal plasma flow, and kidney volume were identical in the two groups at the start of the study, although ... | 2009 | 2951131 |
| reflex sympathetic dystrophy following nail biopsy. | reflex sympathetic dystrophy following a nail unit biopsy in a patient with long-standing, mycologically negative onychomycosis is reported. the significance of this complication is discussed, and the literature on the condition itself is reviewed. it is suggested that although adverse effects occur as a result of nail biopsy, they are infrequent and therefore should not dissuade the clinician from performing the procedure. biopsy is necessary in order to establish a more accurate diagnosis of n ... | 2010 | 2950143 |
| treatment of mooren's ulcer with cyclosporin a: report of three cases. | three patients with severe, bilateral, progressive mooren's ulcers, unresponsive to medical and surgical therapy, were treated with cyclosporin a. all three responded rapidly to the drug and there has been no recurrence of the mooren's ulcers since (average follow-up 14 months). peripheral blood t lymphocyte subsets were estimated prior to and during treatment. no significant abnormalities were found initially. suppressor cells increased on treatment, and a corresponding drop of the helper/suppr ... | 2010 | 2949775 |
| ultrastructural changes in the sarcoplasmic reticulum in acute myocardial ischemia. | we investigated the morphologic changes in the sarcoplasmic reticulum (sr) in acute myocardial ischemia, induced by occlusion of the coronary artery in the canine heart, by freeze-fracture of sr in situ and in vitro, and they were compared to the alterations in ca++-stimulated atpase activity and protein composition of the isolated sr. both sr in situ and the isolated sr exhibited typical intramembranous particles with diameters of 70 to 90 a in freeze-fracture replicas. the intramembranous part ... | 1986 | 2948034 |
| structure-activity relationships of sex steroid analogs determined in vitro in a thyroid hormone-responsive membrane ca2+-atpase model. | physiological concentrations of l-t4 were found previously to stimulate ca2+-atpase activity in vitro in reticulocyte membranes from female rabbits and to inhibit this enzyme in reticulocyte membranes from males. in these previous studies, preincubation of intact cells or ghosts with testosterone (5 x 10(-11) m) converted female-source reticulocyte membranes to male-type responsiveness to thyroid hormone (inhibition of ca2+-atpase activity). preincubation of reticulocyte membranes with 17 beta-e ... | 1986 | 2946570 |
| structure-activity relationships of sex steroid analogs determined in vitro in a thyroid hormone-responsive membrane ca2+-atpase model. | physiological concentrations of l-t4 were found previously to stimulate ca2+-atpase activity in vitro in reticulocyte membranes from female rabbits and to inhibit this enzyme in reticulocyte membranes from males. in these previous studies, preincubation of intact cells or ghosts with testosterone (5 x 10(-11) m) converted female-source reticulocyte membranes to male-type responsiveness to thyroid hormone (inhibition of ca2+-atpase activity). preincubation of reticulocyte membranes with 17 beta-e ... | 1986 | 2946570 |
| dose-related effects of synthetic human beta-endorphin and naloxone on fed gastrointestinal motility. | in humans, plasma beta-endorphin levels rise during application of acute stressful stimuli (vertigo, cold pain, and transcutaneous electrical stimulation) that induce gut motor disturbances. whereas it is possible that circulating beta-endorphin participates in the mediation of these central effects on gut motility, its role cannot be established solely on the basis of changes in plasma levels. therefore, we designed the present study to investigate 1) the dose-related effects of intravenous syn ... | 1986 | 2942039 |
| [an experience with combined procurement of the liver and kidneys for transplantation by a british team (cambridge)]. | 2010 | 2935806 | |
| [how to prevent the tumor lysis syndrome]. | 2010 | 2935797 | |
| [bone marrow necrosis. apropos of 2 cases]. | 2007 | 2933830 | |
| nh2-terminal amino acid sequence analysis of qa-2 alloantigens. | 2010 | 2925232 | |
| vibrio vulnificus corneal ulcer. case reports. | 1989 | 2923553 | |
| degradation of type ix collagen by matrix metalloproteinase 3 (stromelysin) from human rheumatoid synovial cells. | the degradation of type ix collagen, a minor collagen in cartilage, was examined by treatment with three different types of matrix metalloproteinases (mmps) purified from the culture medium of rheumatoid synovial cells. neither mmp-1 (collagenase) nor mmp-2 (so-called 'gelatinase') could digest type ix collagen, but mmp-3 (stromelysin) readily degraded it into smaller fragments. this suggests that mmp-3 may be responsible for the pathological degradation and/or normal turnover of type ix collage ... | 1989 | 2920840 |
| [medical journals and editorial freedom]. | 2009 | 2919151 | |
| human milk feeding enhances the urinary excretion of immunologic factors in low birth weight infants. | the effects of fortified human milk feedings on the urinary excretion of lactoferrin, lysozyme, secretory component, iga, and secretory iga antibodies to escherichia coli o antigens were investigated in very low birth wt infants. infants were maintained on either a human milk or a cow's milk preparation. the amounts of each immune factor that were ingested and excreted were quantified during balance studies conducted at 2.5 and 5 wk of age. serum levels of these immune factors were similar in bo ... | 1989 | 2919134 |
| the craniofacial morphology in persons with maxillonasal dysplasia (binder syndrome). a longitudinal cephalometric study of orthodontically treated children. | the aim of this investigation was to study the influence of orthodontic treatment on facial growth in subjects with maxillonasal dysplasia. the subjects were followed longitudinally from early childhood until growth was completed or almost completed. fifteen patients, 9 boys and 6 girls, were orthodontically treated by conventional methods. they were compared with (1) another longitudinal group consisting of 13 orthodontically untreated children, 7 boys and 6 girls with the same syndrome, and (2 ... | 2010 | 2916471 |
| clinical and radiologic features of lacunar versus nonlacunar minor stroke. | we determined the angiographic presence of extracerebral and intracerebral arterial disease in 122 patients with minor stroke within the carotid territory; we excluded patients with a recognized cardiac source of emboli. based on clinical features and computed tomographic findings, patients were classified as having lacunar infarcts (n = 61), nonlacunar infarcts (n = 53), and infarcts of indeterminate type (n = 8). severe carotid bifurcation disease (greater than or equal to 50% stenosis or occl ... | 2010 | 2911836 |
| an experimental study of susceptibility to infection after hemorrhagic shock. | hemorrhagic shock has been associated with an increased risk of infection after injury. the immediate and long term effects of hemorrhagic shock without tissue injury on the susceptibility of an animal to infection and the efficacy of antibiotic prophylaxis to prevent infection in this setting were examined. sprague-dawley rats were subjected to hemorrhagic shock (ld15) by bleeding to a mean arterial pressure of 45 millimeters of mercury for 45 minutes and were resuscitated with shed blood and n ... | 1989 | 2911791 |
| the androgenicity of progestational agents. | androgenic potency of the progestational component in oral contraceptives (ocs) is difficult to assess. all the 19-nor testosterone progestogens in oc formulations basically have similar potencies and androgenic activities with the exception of norgestrel (ng). ng is the most potent and androgenic of these agents. it is five to ten times as potent as norethindrone (net); levonorgestrel (1-ng), one of the two isomers of ng and the one responsible for its potency, is ten to 20 times more potent th ... | 2009 | 2908040 |
| eukaryote membrane genetics: the fo sector of mitochondrial atp synthase. | 1988 | 2907692 | |
| changes in the metabolic profile of the equine gluteus medius as a function of sampling depth. | 1. cross sections from the middle of the gluteus medius were removed from 10 adult horses and used to evaluate changes in histochemically determined muscle fiber type and biochemically determined metabolic enzyme activities as a function of sample depth. 2. muscle fiber types determined using histochemical methods for myosin atpase (ph 9.4) and succinic dehydrogenase (sdh) activity indicated percent fast-twitch glycolytic (fg) muscle fibers decreased and slow-twitch oxidative (so) fibers increas ... | 1988 | 2907449 |
| neuronal interactions between neuropeptide y (npy) and catecholaminergic systems in the rat arcuate nucleus as shown by dual immunocytochemistry. | several recent studies have suggested interactions between catecholamine (ca) and neuropeptide y (npy) neuronal systems in the rat brain. in order to obtain morphological evidence for such ca/npy interactions in the arcuate nucleus, we have used a double immunostaining procedure using an anti-tyrosine hydroxylase (th) antiserum as a marker for catecholamine neurons and an anti-npy antiserum. this double staining, where the first staining is silver-gold intensified, was detectable at both light a ... | 1988 | 2901738 |
| inhibitory effect of glycyrrhetinic acid derivatives on arachidonic acid-induced mouse ear oedema. | the inhibitory effects of glycyrrhetinic acid and its derivatives were examined on arachidonic acid (aa)-induced ear oedema in mice. of the compounds, dihemiphthalate derivatives of 18 beta-olean-12-ene-3 beta, 30-diol (iid, iid'), 18 beta-olean-9(11)12-diene-3 beta, 30-diol (iiia, iiia') and olean-11, 13(18)-diene-3 beta, 30-diol (iva, iva') showed a strong inhibition of ear oedema on both tropical (id50, 1.9, 2.8 and 1.7 mg/ear, respectively) and oral (id50, 90, 130 and 88 mg kg-1, respectivel ... | 1988 | 2900308 |
| importance of pulmonary blood volume and aortic blood pressure in regulation of left ventricular function. | 1988 | 2900297 | |
| inhibition of nucleic acid synthesis in p-388 lymphocytic leukemia cells in culture by sesquiterpene lactones. | helenalin and bis (helenalinyl) malonate, sesquiterpene lactones, were shown to be cytotoxic against the growth of p-388 lymphocytic leukemia cells in culture. dna and protein synthesis were reduced by these agents preferentially, with rna synthesis being affected only marginally. this study focused on the identification of the enzyme target(s) responsible for the inhibition of dna synthesis by the sesquiterpene lactones. purine synthesis was strongly inhibited at the imp dehydrogenase step. sup ... | 2010 | 2895992 |
| isolated duodenal tamponade for treatment of bleeding duodenal ulcer. | 2010 | 2895833 | |
| diabetogenic action of calcitonin in acute experiment in healthy humans. | 2010 | 2894137 | |
| a unique t-cell line derived from an htlv-1-negative adult t-cell leukemia patient. | a unique t-cell line, designated atl-5t, was established from lymphoma cells in pericardial effusion of an adult t-cell leukemia (atl) patient not carrying htlv-1 provirus. the cell line is okt4 and/or leu3a+ and okt8 and/or leu2a+, but interleukin 2 receptor (il2r)- and htlv-1 provirus genome negative, and has cytogenetically abnormal karyotypes. the cell line contains rearranged t-cell receptor beta-chain gene, which was identical in rearrangement pattern to the t-cell receptor beta-chain gene ... | 1987 | 2890613 |
| [h2-antihistaminics. 35. synthesis and h2-antagonistic action of imidazolylmethylthioalkyl-substituted 1,2,4-triazoles]. | 1987 | 2889442 | |
| chlamydia trachomatis in antenatal clinics. | 1987 | 2889053 | |
| absence of age-related changes in the binding of the beta adrenergic antagonist 125i-iodohydroxybenzylpindolol in rat heart. | the effect of age on the density and the affinity of beta adrenergic receptors was determined in the hearts of fischer 344 rats at three ages, 6, 12, and 24 months old. the binding of the beta adrenergic antagonist 125i-iodohydroxybenzylpindolol (ihyp), was used to quantitate and characterize cardiac beta adrenergic receptors. the maximal number of binding sites (bmax = f moles/mg of protein) were 26.3 +/- 2.5, 25.4 +/- 0.99, and 24.5 +/- 2.4 and the dissociation constants (kd = nm) were 0.166 + ... | 1987 | 2888126 |
| congenital adrenal hyperplasia. | 2010 | 2887945 | |
| glutathione metabolizing enzyme activities in human thyroid. | glutathione peroxidases, glutathione transferase, glutathione reductase and gamma-glutamyl transpeptidase activities were analyzed in human thyroid tissues obtained from 17 patients undergoing resectional surgery because of a malignancy. it was deduced, from measurements of glutathione peroxidase activity with both h202 and cumene hydroperoxide, that thyroid contains only the selenium enzyme. the absence of selenium independent glutathione peroxidase activity in thyroid was confirmed with gel fi ... | 1987 | 2883074 |
| 1,4-dithiothreitol-induced changes in histamine h1-agonist efficacy and affinity in the longitudinal smooth muscle of guinea-pig ileum. | the effect of 1,4-dithiothreitol (dtt) on histamine h1-receptor agonist affinity and efficacy has been investigated in longitudinal muscle strips of guinea-pig ileum. exposure of ileal smooth muscle to dtt significantly increased the maximal responses to the partial agonists skf71473 and de-2pea, indicative of an increase in agonist efficacy. this effect was paralleled by a small decrease in ec50 values. in contrast, dtt produced a parallel displacement of the concentration-response curve to the ... | 1987 | 2880626 |
| adenosine receptors mediate pigment dispersion in leucophores of the medaka, oryzias latipes. | using the medaka, oryzias latipes (orange-red variety), the mechanisms of action on leucophores of adenosine and adenine nucleotides, including cyclic amp, were studied. all these substances were found to be very effective in dispersing leucosomes. their pigment-dispersing action was antagonized by methylxanthines. these substances did not aggregate leucosomes. it was concluded that leucophores possess specific binding sites for adenosine, i.e. adenosine receptors, on the cell membrane, which me ... | 2010 | 2877798 |
| directives, methods and suggestions for anti-ulcer drug therapy. | 2010 | 2876535 | |
| effects of somatostatin and sms 201-995 on carbohydrate metabolism in normal man. | growth hormone (gh) is important in diabetes in view of its anti-insulin actions and its relation to the long-term complications of the disease. the suppression of gh secretion in diabetics has theoretical and possible therapeutic interest. native somatostatin has multiple actions, including inhibition of the secretion of insulin, glucagon, thyroid-stimulating hormone (tsh), and various gut hormones. it also has inhibitory effects on gastrointestinal motility, exocrine secretion, nutrient absorp ... | 1986 | 2876501 |
| [arterial hypertension in the aged]. | 2010 | 2876472 | |
| report of a wound infection caused by vibrio parahaemolyticus and vibrio vulnificus. | the present case describes a foot wound caused by a clam shell from which both vibrio parahaemolyticus and vibrio vulnificus were recovered. although extraintestinal infections associated with vibrio parahaemolyticus have been reported previously, the simultaneous isolation of two marine vibrios from our case suggests that these organisms may coexist in mixed infections from a common source. | 1986 | 2875824 |
| pain, prostaglandins, and food lipids. influences of dietary polyunsaturated fatty acids on eicosanoid synthesis and effects. | 2007 | 2870709 | |
| accessory adrenal: an incidental finding during orchiopexy. | 2006 | 2870456 | |
| [pharmacokinetic interaction of drugs with cardiac glycosides; which are clinically important?]. | 2006 | 2870436 | |
| in-vivo fertilised ovum donated successfully to a woman without ovaries. | 2005 | 2870261 | |
| synthesis and quantitative structure-activity relationships of antiallergic 2-hydroxy-n-1h-tetrazol-5-ylbenzamides and n-(2-hydroxyphenyl)-1h-tetrazole-5-carboxamides. | the synthesis and antiallergic activity of a series of 2-hydroxy-n-1h-tetrazol-5-ylbenzamides and isomeric n-(2-hydroxyphenyl)-1h-tetrazole-5-carboxamides is described. a relationship between structure and intravenous antiallergic activity in the rat passive cutaneous anaphylaxis (pca) test has been established using a hansch/free-wilson model and used to direct studies toward potent derivatives. the contribution of physicochemical properties to activity is discussed. one member of this series, ... | 1986 | 2870188 |
| neural and pavlovian influences on immunity. | the traditional view that the nervous and immune systems are functionally independent (aside from general stress effects and autoimmune disorders of the nervous system) is being challenged by a new view that the nervous system regulates the activity of the immune system. if this is true, it should be possible to change the activity of the immune system by means of pavlovian conditioning, just as it is possible to condition other physiological events influenced by the autonomic nervous system or ... | 1985 | 2866484 |
| hypotensive effects after topical and intra-arterial administration of alpha-adrenergic agonists in isolated perfused rabbit eyes. | the influence of nonselective and selective alpha-adrenergic agonists on intraocular pressure (iop) was studied in isolated arterially perfused rabbit eyes. drugs were given intra-arterially or topically. with either route of administration, no initial hypertensive phase was observed after l-epinephrine, l-norepinephrine, l-phenylephrine (alpha 1), or methoxamine (alpha 1), but there was an immediate ocular hypotensive effect. the alpha 2-agonist b-ht 920 caused a nonsignificant 1 mm hg fall in ... | 1985 | 2866480 |
| [physiological and pharmacologic studies of the adrenal medulla by the measurement of plasma catecholamine levels]. | the new techniques for the assay of the plasma catecholamines: noradrenaline, dopamine and, most importantly, adrenaline, because of their sensitivity and precision, have provided new information about the physiology and the pharmacology of the adrenal medulla in animals and in man. the most effective of these new techniques are the radioenzymatic techniques. the activation of the adrenal medulla in the dog or the rat appears to be frequency-dependent by maintaining a fixed concentration ratio i ... | 1985 | 2863423 |
| lymphatic transport of sodium cefoxitin in the presence of sodium 5-methoxysalicylate after injection into rat rectal connective tissue, femoral muscle and femoral vein. | lymphatic uptake of sodium cefoxitin after injection into rectal connective tissue was greater than after injection into the femoral muscle of rats. coadministration with sodium 5-methoxysalicylate enhanced lymphatic drug uptake at both sites. this enhancement may be an indirect result of 5-methoxysalicylate's suppression of vascular permeation of the cefoxitin. an adjuvant-induced increase in lymphatic fluid flow may also be partially involved in the enhancement of cefoxitin lymphatic transport ... | 1985 | 2863362 |
| immunochemical recognition of oxytocin by antiserum to l-prolyl-leucyl-glycine amide. | antisera were raised in rabbits against pro-leu-gly-nh2 (plg)-bovine thyroglobulin conjugates. specificity of the antisera towards oxytocin was evaluated by a radioimmunoassay as well as by immunohistochemical procedures on hypothalamic tissue and hormone bound to sepharose beads. it was concluded that immunization with plg can raise antisera that are specific to oxytocin. | 1985 | 2859563 |
| benzodiazepines enhance the muscimol-dependent activation of phospholipase a2 in glioma c6 cells. | glioma c6 cells were incubated with [14c]arachidonate to label membrane phospholipids. muscimol, a selective gamma-aminobutyric acid a receptor agonist, but not (-)-baclofen, a selective gamma-aminobutyric acid b receptor agonist, stimulates [14c]arachidonate release from c6 cells as a result of hydrolysis of a small pool of phosphatidylcholine and phosphatidylethanolamine by phospholipase a2. this release is facilitated by diazepam and a number of other benzodiazepines such as flunitrazepam, me ... | 1985 | 2857784 |
| survival of smallpox virus. | 1985 | 2857360 | |
| a murine monoclonal antibody raised against human non-small cell carcinoma of the lung. | murine monoclonal antibodies (mabs) reactive with human non-small cell carcinoma of the lung (nsccl) were produced following immunization with a membrane preparation of calu-3, a human adenocarcinoma of the lung cell line grown in nude mice. positive hybrids unreactive with normal liver membranes and human peripheral white blood cells were selected for further testing. one mab (rs5-4h6) recognized an antigen expressed in a variety of lung and other carcinoma cell lines as detected by flow cytome ... | 1988 | 2853133 |
| [changes in the cyclic nucleotide system of t-lymphocytes in experimental tuberculosis in animals]. | 1988 | 2851783 | |
| suppression of sv40-promoted gene expression by differentiation of preadipose cells. | when a plasmid bearing the chloramphenicol acetyltransferase (cat) gene under the control of an sv40 early promoter is introduced into preadipose or adipose cells of line 3t3-f442a, the promoter directs high levels of transient expression of cat. however, when the plasmid is introduced into preadipose cells and the cells are then allowed to differentiate into adipose cells, the expression of the cat gene is suppressed. in this process, the plasmid is not changed detectably in amount, topology, o ... | 1988 | 2849579 |
| factors influencing the severity of escherichia coli and avian adenovirus group ii infections in chickens. | chickens from lines selectively bred for either a high (hh) or low (ll) antibody response to sheep erythrocytes were challenged intravenously with avian adenovirus group ii (aa). spleen size was determined 6 days later. in some experiments the responses of chickens to aa and escherichia coli infections were compared. the level of corticosterone in the feed (15 mg/kg) which resulted in the lowest incidence of pericarditis in response to e. coli resulted in the greatest incidence of large spleens ... | 1988 | 2849405 |
| [the entero-insular axis: the new incretin candidate glucagon-like peptide-1(7-36)amide (glp-1(7-36))amide]. | the functional connection between the gut and pancreatic islets is described by the term "enteroinsular axis". a humoral factor of the gut that might enhance the glucose-induced secretion of insulin is named "incretin". for many years glucose-dependent insulin-releasing polypeptide (gip) was the strongest incretin candidate. however, recent evidence suggests that glucagon-like peptide-1(7-36)amide represents a more potent physiological incretin. the sequence of glp-1 is identical in various mamm ... | 1988 | 2849249 |
| transcriptional regulation of the gene encoding the major surfactant protein (sp-a) in rabbit fetal lung. | the expression of the major protein of rabbit pulmonary surfactant (sp-a), a glycoprotein of mr congruent to 29,000-36,000, is regulated during development and by hormones. in the present study, utilizing a cdna insert complementary to mrna coding for sp-a and nuclear transcription elongation assays, we have investigated the developmental and hormonal regulation of transcription of the sp-a gene in rabbit fetal lung tissue. the relative rates of transcription of sp-a mrna increased as a function ... | 1988 | 2848814 |
| chemotaxis in eukaryotic cells: a focus on leukocytes and dictyostelium. | 2010 | 2848555 | |
| specificity of synapse formation in the cockroach. | the synaptic connection between the filiform hair sensory neurons (fhsns) and the giant interneurons (gis) in the terminal abdominal ganglion of the first-instar cockroach periplaneta americana has been used as a model system for investigating the mechanism of synaptic specificity. electrophysiological and electron microscopical techniques were used to determine the normal patterns of connectivity between fhsns and gis. it was found that, even during synaptogenesis, no incorrect synapses were fo ... | 2009 | 2847212 |
| specificity of synapse formation in the cockroach. | the synaptic connection between the filiform hair sensory neurons (fhsns) and the giant interneurons (gis) in the terminal abdominal ganglion of the first-instar cockroach periplaneta americana has been used as a model system for investigating the mechanism of synaptic specificity. electrophysiological and electron microscopical techniques were used to determine the normal patterns of connectivity between fhsns and gis. it was found that, even during synaptogenesis, no incorrect synapses were fo ... | 2009 | 2847212 |
| thiol peroxyl radical formation from the reaction of cysteine thiyl radical with molecular oxygen: an esr investigation. | using electron spin resonance (esr) spectroscopy, we have identified the cysteine thiol peroxyl radical (cyssoo.) at low temperatures in two aqueous glasses. this radical shows a typical peroxyl radical esr spectrum, but unlike carbon-based peroxyl radicals has a violet color (lambda max = 540 nm) and forms a new radical showing a singlet esr spectrum when photobleached with visible light. the cysteine peroxyl radical reacts to form the cysteine sulfinyl radical (cysso.) in the glass which allow ... | 2010 | 2843184 |
| evaluation of guar biscuits for use in the management of diabetes: tests of physiological effects and palatability in non-diabetic volunteers. | a guar-shortbread biscuit has been successfully developed and tested for possible use in the dietary management of diabetes. a dose-response study was undertaken to estimate the amount of guar gum needed in the biscuit recipe to reduce postprandial glycaemia and insulinaemia. a control biscuit and three types of guar biscuit corresponding to a low, medium and high dose of guar (2.9, 6.0 and 9.1 g of guar respectively) were given to 8 non-diabetic subjects, and blood glucose and plasma insulin le ... | 2010 | 2840279 |
| mechanism of the epsp synthase catalyzed reaction: evidence for the lack of a covalent carboxyvinyl intermediate in catalysis. | in order to detect covalent reaction intermediates in the 5-enolpyruvylshikimate-3-phosphate (epsp) synthase reaction, we have investigated the interaction of epsp synthase with the reaction product epsp. an exchange of epsp-methylene protons could be demonstrated by incubating epsps with epsp in d2o. since trace amounts of contaminating pi would lead to reversal of epsps reaction and hence methylene proton exchange, we added pyruvate kinase, adp, mg++ and k+. under these conditions, any contami ... | 1988 | 2838023 |
| [fatal septicemia of vibrio vulnificus in a patient with chronic hepatitis]. | 1987 | 2836645 | |
| short-chain fatty acid transport in the intestine of a herbivorous teleost. | short-chain fatty acid (scfa) concentrations of intestinal contents from the herbivorous tilapia, oreochromis mossambicus, were analysed by gas and high-performance liquid chromatography. concentrations of acetate ranging from 3 to 18 mmol l-1 were found along the full length of the intestinal tract, as were trace amounts of propionate. characteristics of [3h]acetate transport by the intestinal brush-border membrane were analysed in isolated brush-border membrane vesicles (bbmv). influx of [3h]a ... | 2009 | 2836545 |
| short-chain fatty acid transport in the intestine of a herbivorous teleost. | short-chain fatty acid (scfa) concentrations of intestinal contents from the herbivorous tilapia, oreochromis mossambicus, were analysed by gas and high-performance liquid chromatography. concentrations of acetate ranging from 3 to 18 mmol l-1 were found along the full length of the intestinal tract, as were trace amounts of propionate. characteristics of [3h]acetate transport by the intestinal brush-border membrane were analysed in isolated brush-border membrane vesicles (bbmv). influx of [3h]a ... | 2009 | 2836545 |
| propranolol enhances in vitro interleukin 2 receptor expression on human lymphocytes. | interleukin 2 receptor (il-2r) expression was assessed, using anti-tac monoclonal antibody, after incubation of human lymphocytes with the beta-adrenoceptor antagonist propranolol (pro). one-hour incubation of mononuclear cells (mnc) with pro resulted in an increase of tac positive cells. the greatest rise was observed with a pro concentration of 10(-6) m (29% ring-stained cells compared with 0% in the control group). cells cultured for 3 days with pro showed a lower proportion of tac positive c ... | 1988 | 2836304 |
| cloning and expression of the vibrio cholerae neuraminidase gene nanh in escherichia coli. | a cosmid gene bank of vibrio cholerae 395, classical ogawa, was screened in escherichia coli hb101 for expression of the vibrio neuraminidase (nanase) gene nanh (n-acylneuraminate glycohydrolase). positive clones were identified by their ability to cleave the fluorogenic nanase substrate 2'-(4-methylumbelliferyl)-alpha-d-n-acetylneuraminic acid. seven nanase-positive clones were detected after screening 683 cosmid isolates with a rapid, qualitative plate assay method. the nanh gene was subcloned ... | 1988 | 2832365 |
| cloning and expression of the vibrio cholerae neuraminidase gene nanh in escherichia coli. | a cosmid gene bank of vibrio cholerae 395, classical ogawa, was screened in escherichia coli hb101 for expression of the vibrio neuraminidase (nanase) gene nanh (n-acylneuraminate glycohydrolase). positive clones were identified by their ability to cleave the fluorogenic nanase substrate 2'-(4-methylumbelliferyl)-alpha-d-n-acetylneuraminic acid. seven nanase-positive clones were detected after screening 683 cosmid isolates with a rapid, qualitative plate assay method. the nanh gene was subcloned ... | 1988 | 2832365 |
| cilia-associated respiratory (car) bacillus infection of obese mice. | cilia-associated respiratory (car) bacillus was identified in respiratory tract lesions of obese mice dying of chronic respiratory disease. neither mycoplasma pulmonis nor pathogenic bacteria were isolated from cultures of the lesions at necropsy, but there was serologic and histologic evidence of respiratory virus infection. cranial-ventral areas of lung were firm and demarcated from unaffected lung at gross examination, and representative tissue sank in water. microscopically, there was suppur ... | 1988 | 2830699 |
| cilia-associated respiratory (car) bacillus infection of obese mice. | cilia-associated respiratory (car) bacillus was identified in respiratory tract lesions of obese mice dying of chronic respiratory disease. neither mycoplasma pulmonis nor pathogenic bacteria were isolated from cultures of the lesions at necropsy, but there was serologic and histologic evidence of respiratory virus infection. cranial-ventral areas of lung were firm and demarcated from unaffected lung at gross examination, and representative tissue sank in water. microscopically, there was suppur ... | 1988 | 2830699 |
| mononuclear cell infiltration in central portions of human astrocytomas. | the mononuclear cell infiltration in the central portion of human low- and high-grade astrocytomas has been examined using monoclonal antibodies to cell surface differentiation antigens. there was no significant difference between the number of t cells, b cells, or macrophages. the okt8+ (suppressor/cytotoxic) t cell population was the major lymphocyte subset in the infiltrates. there was, however, indirect evidence for a proportion of the total okt8+ cells being natural killer cells. overall, t ... | 1988 | 2830373 |
| mononuclear cell infiltration in central portions of human astrocytomas. | the mononuclear cell infiltration in the central portion of human low- and high-grade astrocytomas has been examined using monoclonal antibodies to cell surface differentiation antigens. there was no significant difference between the number of t cells, b cells, or macrophages. the okt8+ (suppressor/cytotoxic) t cell population was the major lymphocyte subset in the infiltrates. there was, however, indirect evidence for a proportion of the total okt8+ cells being natural killer cells. overall, t ... | 1988 | 2830373 |
| cytomegalovirus pneumonia. | cytomegalovirus (cmv) is a common virus that asymptomatically infects the majority of the population by early adulthood. after initial infection, the virus remains in a latent state in the host and can be reactivated under a variety of conditions. in contrast to the normal host, both primary and reactivated symptomatic cmv infections are common in certain immunocompromised patients including organ transplant recipients and patients with the acquired immunodeficiency syndrome (aids). one of the m ... | 1987 | 2827281 |
| overlapping distributions of receptors for atrial natriuretic peptide and angiotensin ii visualized by in vitro autoradiography: morphological basis of physiological antagonism. | atrial natriuretic peptides exert actions on many key organs involved in blood pressure and water and electrolyte balance. many of these actions result in a physiological antagonism of angiotensin. to investigate the morphological basis of this interaction, we have mapped the distribution of receptors for atrial natriuretic peptide and angiotensin ii in a number of target organs, using 125i-labelled rat atrial natriuretic peptide (99-126) and 125i-labelled [sar1,ile8]angiotensin ii. in the kidne ... | 1987 | 2825937 |
| dopamine denervation of the nucleus accumbens induces a selective increase in the number of delta-opioid binding sites. | selective lesions of dopamine (da) neurons of the nucleus accumbens were made in rats by local injections of 6-hydroxydopamine (6-ohda). seven days after 6-ohda, the binding affinities and capacities at mu-, delta- and kappa-opioid binding sites were determined in the nucleus accumbens by selective labelling techniques. 6-ohda pretreatment caused a significant increase in the number of delta-opioid binding sites (+30%) while the number of mu-, kappa- and total sites was not modified. the affinit ... | 1987 | 2825926 |
| dopamine denervation of the nucleus accumbens induces a selective increase in the number of delta-opioid binding sites. | selective lesions of dopamine (da) neurons of the nucleus accumbens were made in rats by local injections of 6-hydroxydopamine (6-ohda). seven days after 6-ohda, the binding affinities and capacities at mu-, delta- and kappa-opioid binding sites were determined in the nucleus accumbens by selective labelling techniques. 6-ohda pretreatment caused a significant increase in the number of delta-opioid binding sites (+30%) while the number of mu-, kappa- and total sites was not modified. the affinit ... | 1987 | 2825926 |
| [mechanisms of hypergastrinemia after vagotomy]. | 1987 | 2824916 | |
| [mechanisms of hypergastrinemia after vagotomy]. | 1987 | 2824916 | |
| depolarization induced by injection of cyclic nucleotides into frog taste cell. | in order to identify the intracellular transmitter involved in the taste transduction process, cyclic nucleotides were iontophoretically injected into the frog taste cells while membrane potentials were recorded intracellularly. injection of either cyclic gmp or cyclic amp induced a depolarization response of about 5 mv in the taste cells, but injection of cl- had no effect. the rate of a repolarization after the depolarization elicited by cyclic gmp was larger than that after cyclic amp. the po ... | 2009 | 2822117 |
| depolarization induced by injection of cyclic nucleotides into frog taste cell. | in order to identify the intracellular transmitter involved in the taste transduction process, cyclic nucleotides were iontophoretically injected into the frog taste cells while membrane potentials were recorded intracellularly. injection of either cyclic gmp or cyclic amp induced a depolarization response of about 5 mv in the taste cells, but injection of cl- had no effect. the rate of a repolarization after the depolarization elicited by cyclic gmp was larger than that after cyclic amp. the po ... | 2009 | 2822117 |
| a photographic study of enamel defects among south australian school children. | colour photographs were taken of the anterior teeth of 1757 consenting 8-9 year old primary school children in fluoridated and non-fluoridated areas of south australia. children with a lifelong exposure to fluoridated water were significantly more likely to have blemished permanent incisor teeth than the children who had never resided in a fluoridated area. children who resided in a non-fluoridated area but had taken fluoride supplements at some stage in their first five years had a prevalence o ... | 2009 | 2818303 |
| the dermatopathologist and human immunodeficiency virus infection. | 1989 | 2817921 | |
| [5 years' infection statistics of an orthopedic clinic--pathogen spectrum, resistance status, therapeutic consequences]. | in 1983 we started our statistical control for postoperative infections. the data are checked every half year. most common bacteria was staph. aureus followed by staph. epidermidis. we found a difference in the spectrum of bacteria between our postop. patients and the referred cases. a surgeon related control and our new operating theatres reduced the infection rate from 2.2% to 0.8%. for our total joint replacements we additionally used perioperative antibiotics. the change in the antibiotic fr ... | 2009 | 2815951 |
| physical exercise--an important factor for health. a position statement from the international federation of sports medicine. | 2010 | 2814432 |