Publications

the use of fa-technique for detecting francisella tularensis in formalin fixed material. a method useful in routine post mortem work.		1981	7046398
[experimental latent tularemia in common voles].	common voles (microtus subarvalis) were infected with tularemia by feeding them with the corpses of the animals which had been infected with francisella tularensis strain having somewhat decreased virulence. this resulted in nonlethal infection in 14 out of 433 voles used in the experiment. a considerable part of the animals having had the infection developed bacterial carriership (11 out of 13 animals) with bacteriuria (8 out of 11 animals) lasting up to 2 months. the persistence of francisella ...	1982	7043979
towards serodiagnosis of serratia marcescens infections: examination of sera from noninfected patients and from experimentally infected rabbits for anti-h and anti-o antibodies; s. marcescens o-antigen cross-reactions with those of other enterobacteriaceae.	sera from 100 patients not infected with serratia marcescens at the time of hospital admission lacked detectable h-immobilizing antibodies against all 20 currently recognized h-antigens of this microorganism. however, various patient sera revealed elevated titers of o-agglutinins against several of the 20 o-antigens of s. marcescens, in a particular o-antigens, o1, o3, o4, o5, o7, o8, o10, o11, o16, o17, o18, o19, and o20. rabbit anti-shigella serogroup b immune serum cross-reacted with s. marce ...	1981	7036590
mothers of infants with neonatal group b streptococcal septicemia are poor responders to bacterial carbohydrate antigens.	serum antibodies against various carbohydrate antigens were studied in 16 mothers of infants with serious infections caused by group b streptococci (gbs) (the study group), and compared with a control group of 29 urogenital carriers of gbs who gave birth to neonatally healthy infants. using a radioimmunoassay for the determination of antibodies to gbs types ia, ib, ii and iii, it was found that the study group had significantly lower levels of igg antibodies to each of the 4 gbs types than the c ...	1982	7035374
influence of complement on the chemiluminescent response of human leukocytes to immune complex.	vaccine bacteria of francisella tularensis were mixed with human serum containing specific antibodies against the same organism, and the mixture was incubated at 37 degrees c for 30 min. the mixture induced a two-peak chemiluminescent response in polymorphonuclear leukocytes. the initial peak was induced by a soluble agent, formed during incubation. the formation of this agent involved the activation of complement component c5. the second peak of the chemiluminescent response was induced by the ...	1980	7011971
cell-mediated immunity against francisella tularensis after natural infection.	31 subjects with tularemia recently or up to 11 years earlier were studied for cell-mediated immunity against francisella tularensis using formalin-killed bacteria as antigen in the lymphocyte blast transformation test. lymphocytes from all the subjects responded to f. tularensis antigen both in separated mononuclear cell and whole blood cultures, whereas lymphocytes from 12 controls responded not at all or only weakly to hig antigen concentrations and only in separated mononuclear cell cultures ...	1980	7006062
[technic of studying microorganism viability in a simulated aerosol state on fiberglass microfilaments].	a specially developed method of studying the viability of microorganisms in the simulated aerosol state on glass microfibers was used to show that the survival rate of e. coli and f. tularensis on fiber-glass spheres was similar to that in true aerosol, as observed in a static aerosol chamber. the proposed method allows to study the viability of microbial cells after prolonged existence in aerosol under any environmental condition both in open spaces and closed rooms.	1980	7001815
a probable endocrine basis for the depression of ketone bodies during infectious or inflammatory state in rats.	the effects of infection with streptococcus pneumoniae, francisella tularensis, and venezuelan equine encephalitis virus as well as inflammatory stress induced by the administration of turpentine and endotoxin on plasma ketone bodies and insulin were studied in white rats. all of the infectious/inflammatory stresses caused a significant decrease in the ketonemia of fasting and an elevation of plasma insulin. when a pneumococcal infection was initiated in a diabetic rat, inhibition of fasting ket ...	1980	6993191
[development of a serological micromethod for the detection of antibodies against francisella tularensis].		1980	6982628
clinically mild tularemia associated with tick-borne francisella tularensis.	between may 9 and july 3, 1979, 12 cases of glandular or ulceroglandular tularemia occurred in residents of the crow indian reservation in southcentral montana; only 13 cases had been reported from this geographic area in the preceding 25 years. the illness was mild, characterized by fever and cervical or occipital adenopathy. systemic symptoms were self-limited although residual lymphadenopathy was common. francisella tularensis was isolated from ticks (dermacentor variabilis), the suspected ve ...	1983	6886487
granulomatous pleuritis caused by francisella tularensis: possible confusion with tuberculous pleuritis.	granulomatous pleuritis, diagnosed by pleural biopsy, is rarely caused by disease processes other than tuberculosis. we present a case of granulomatous pleuritis caused by francisella tularensis that occurred in a 55-yr-old male sheep shearer with an exudative, lymphocytic, pleural effusion. confirmation of the diagnosis was made by elevated serum agglutination titers against f. tularensis and detection of the organism in a pleural biopsy specimen by the glucose oxidase immunoenzyme technique. w ...	1983	6881689
a serological survey of antibodies against francisella tularensis in some swedish mammals.	tularemia occurs in sweden as an epizootic among the mountain hare. little is known about the occurrence of the disease in other animals in this country. for this reason serum samples from 28 cattle, 83 moose, 110 beavers and 97 mountain hares were investigated for the presence of antibodies against francisella tularensis. the antibody levels against f. tularensis found in moose and cattle were generally low and also in a low incidence. this indicates that these species are not susceptible to tu ...	1983	6878028
phagocytosis and killing of francisella tularensis by human polymorphonuclear leukocytes.	bacteria of a wild strain of francisella tularensis were less efficiently killed by human polymorphonuclear leukocytes than were bacteria of an attenuated strain. this finding was explained to some extent by a less efficient phagocytosis, but bacteria of the wild strain also seemed to be more resistant to killing after ingestion.	1983	6832815
tularemia complicated by acute renal failure.	acute renal failure has been a rare, uniformly fatal complication of infection with francisella tularensis. the literature suggests that either acute tubular necrosis, interstitial nephritis, or glomerulonephritis may be responsible for this syndrome. we have described a patient with tularemia who had nonoliguric acute renal failure probably due to interstitial nephritis and who recovered slowly but spontaneously during antimicrobial therapy with doxycycline.	1983	6823614
[cytochemical changes in the peripheral blood leukocytes of guinea pigs inoculated against plague, tularemia and anthrax].	the immunization of guinea pigs with trivaccine and monovaccines against plaque, tularemia and anthrax induces a decrease in the activity of acidic phosphatase in lymphocytes, as well as a decrease in the number of lymphocytes containing this enzyme. a decrease in the activity of alkaline phosphatase and peroxidase had been found to occur in neutrophil leukocytes. besides, neutrophil leukocytes have shown an increase in the activity of acidic phosphatase and nonspecific esterases. the study base ...	1982	6812331
induction of resistance to tuberculosis in mice with defined components of mycobacteria and with some unrelated materials.	factors contributing to protection against experimental tuberculosis have been studied with refined and well-characterized fractions from mycobacteria and with certain unrelated antigens. mice were vaccinated intravenously with various combinations of materials presented on minute oil droplets in saline emulsion and were later challenged by aerosol. the minimal composition of an effective vaccine was p3 (a trehalose mycolate similar to cord factor) plus an antigen, which could be tuberculo-prote ...	1982	6805154
[characteristics of microbial multiplication in parenterally infected xenopsylla cheopis (siphonaptera) fleas].	being inoculated parenterally various microbes cause the fleas x. cheopis a stable infection which, as a rule, is preserved in experimental insects to the end of life. reproducing intensively listeria monocytogenes and salmonella typhimurium caused the death of all ectoparasites in 3 to 5 days. the increase in abundance of escherichia coli, yersinia pseudotuberculosis, y. enterocolitica and vaccine strains of y. pestis "ev" and francisella tularensis went on gradually and infected fleas lived up ...	1980	6780964
[current status of vaccine treatment of zoonotic infections].		1980	6776687
glucose and alanine metabolism during bacterial infections in rats and rhesus monkeys.	to investigate the effects of bacterial infection on glucose and alanine metabolism, a variety of studies were carried out in rat and monkey models. these included glucose turnover by a pulse-dose technique in infected rats; alanine and glucose production and utilization in control and septic monkeys; in vivo measurement of gluconeogenesis in rats, with and without an alanine load; the in vitro rate of glucose formation from various substrates by isolated liver perfusion and hepatic cells; and i ...	1980	6768954
bacterial immunizations.		1980	6766272
[disinfection of fresh-frozen sections of ticks infected with the causative agent of tularemia in histoenzymatic studies].		1982	6750344
[time course of the production of immunoglobulins in patients with tularemia].		1984	6748218
[use of an immunoenzyme method on a solid-phase carrier for determining the tularemia antigen].	the method of the highly sensitive (up to 10 ng/ml) and specific determination of soluble tularemia antigen, based on the use of "sandwich" type elisa techniques, has been developed. the dependence of the specificity and sensitivity of the method on the degree of purification of antibodies and their peroxidase conjugates used in the assay has been studied. the study has revealed that the best results can be obtained with the use of purified igg and its conjugate free of unbound peroxidase. both ...	1984	6741370
[antibody dynamics of carnivorous mammals and corvine birds infected with francisella tularensis].	the time course of antibody formation in carnivorous mammals and corvine birds infected with a single injection of f. tularensis has been experimentally studied in the agglutination test and the passive hemagglutination test. in carnivorous mammals the allergic transformation of the body has been established by means of the leukocytolysis test.	1984	6741361
[results of the study of bird droppings collected in the lithuanian ssr for the purpose of searching out tularemia epizootics].	there are practically no records of cases of tularemia among humans in the lithuanian ssr. nevertheless, the mass sero-allergic survey of the population for tularemia, carried out 10-12 years ago, showed that 2.3% of the adult population in the republic had had contacts with the causative agent of this infection. the work was aimed at the determination of the present activity of the foci of tularemia. during 6 years in 22 rural districts 2582 samples of avian excrements, containing bones and woo ...	1984	6711197
tularaemia transmitted by ticks (dermacentor andersoni) in saskatchewan.	common wood ticks (dermacentor andersoni) collected from saskatchewan landing provincial park, saskatchewan in the spring of 1982 transmitted a lethal tularaemia infection to four of six rabbits. francisella tularensis organisms were isolated from tissues taken from the dead rabbits and identified from subcultures using an indirect immunofluorescent antibody assay. one human associated with the animals developed symptoms of tularaemia and, after successful therapy, had a significant increase in ...	1983	6667429
[comparative study of the basic immunological reactions for assessing tularemia immunity in inoculated persons or those who have had the disease].	in the comparative study of immunological tests used for the determination of immunity to tularemia in vaccinees the greatest number of persons with the positive reaction was detected by means of the tularine skin test. former tularemia patients retained allergic skin reaction to this test irrespective of the time of the disease.	1983	6659772
[higher fatty acid composition of the intraspecific taxa of francisella tularensis].	the higher fatty acid composition of 27 f. tularensis strains differing in their biological properties and belonging to different intraspecific taxons has been determined with the use of gas and liquid chromatography. all the strains under study have been found to possess similar fatty acid spectra, characterized by the presence of long straight-chain fatty acids (saturated and unsaturated) with the number of carbon atoms varying from 10 to 26. quantitative differences content of individual fatt ...	1983	6659760
hepatic abscess complicating ulceroglandular tularemia.	in a patient with the clinical features of classic ulceroglandular tularemia a solitary hepatic abscess was found during an ultrasound examination. hepatic tularemia has rarely been reported since the advent of specific therapy, which prevents the disease from reaching the disseminated state. this case, however, shows that the liver can be involved early in the course of tularemia. increased serum levels of hepatic enzymes may be the only sign of such a complication.	1983	6652596
tularemia in a rough-legged buzzard (buteo lagopus) and a ural owl (strix uralensis).		1983	6644938
enzyme-linked immunosorbent assay (elisa) with bacterial sonicate antigen for igm, iga, and igg antibodies to francisella tularensis: comparison with bacterial agglutination test and elisa with lipopolysaccharide antigen.	an enzyme-linked immunosorbent assay (elisa) with bacterial sonicate (s) as antigen developed for determining the presence of igm, iga, and igg antibodies to francisella tularensis was compared with the bacterial agglutination (ba) test and a corresponding elisa using lipopolysaccharide (lps) antigen. of the organisms tested, f tularensis was the only one to cause significant inhibition, indicating the specificity of the s-elisa. ba test titers correlated significantly with antibody levels in al ...	1983	6631062
[the effect of aerosolization on the changes in major biological properties of the vaccine strain of francisella tularensis].	the exposure of f. tularensis vaccine strain 15/10 in the form of aerosol for more than 10 minutes results in the decrease of its virulence, immunogenicity and the content of species-specific antigen and in the increase of the dissociation level. proceeding from this fact, during aerosol immunization with this vaccine strain exposure must not exceed 5 minutes for unstabilized aerosol and 10 minutes for aerosol stabilized with 5% glycerin. under these conditions the properties of f. tularensis st ...	1983	6613417
tularemia pneumonia mimicking legionnaires' disease: isolation of organism on cye agar and successful treatment with erythromycin.	a 46-year-old man showed a clinical response when treated with parenteral erythromycin for what was initially thought to be legionnaires' disease, but an organism isolated from his pleural fluid on cye agar was subsequently identified as francisella tularensis. tularemia should be suspected in all cases of atypical pneumonia in the appropriate setting. erythromycin may be effective empiric therapy in such cases. because of the possibility of inadvertent isolation of francisella tularensis on cye ...	1983	6612398
[isolation and purification of penicillinase from francisella tularensis].	beta-lactamase was isolated from the cells of a penicillinase-producing strain of the tularemia causative agent. it was purified 100 times. by its properties (the substrate profile, km, temperature optimum and thermostability) beta-lactamase differed from penicillinases isolated from other sources.	1983	6606391
[mechanism of natural penicillin resistance in the causative agent of tularemia].	beta-lactamase and penicillinacylase were detected in the tularemia causative agent. these enzymes participated in the mechanism of natural resistance of the microorganisms to penicillins. it was shown that the growth temperature had a significant effect on the beta-lactamase activity. the penicillin resistance marker was not eliminated with the use of acridine orange, ethidium bromide or sodium dodecylsulfate.	1983	6605111
tularemia with unusual laboratory characteristics in south dakota children.		1984	6589779
[nutrient requirements of francisella tularensis].		1984	6464571
[experience with a bacteriologic and serologic study of a tularemia epizootic in rodents in a natural focus of the meadow and field type].	the autumn-winter (1977-1978) tularemia epizootic in small murine rodents was revealed and studied at the natural focus of the meadow and field type in the south of the moscow region. the efficacy of the serologic method (the antibody neutralization test) of studying the organs of the caught rodents and the bodies of dead rodents was found to be greater than that of the traditional bacteriologic methods (26.6% and 9.6%, respectively). the serologic study of 908 specimens of avian excrements coll ...	1981	6454319
[effective method of detecting winter epizootics of tularemia].		1981	6454317
[isolation of the causative agent of tularemia from an inoculum from skin lesions in the ulcerobubonic form of the disease].	a case of tularemia in a human patient infected through the sting of a gadfly (tabanus) is described. the causative agent of the disease was isolated from the patient with the ulcerobubonic form of the disease by the method of the direct inoculation of the contents of the patient's cutaneous effect. the properties of the isolated culture were established; the strain thus obtained was classified as a representative of the geographical race francisella tularensis holarctica 01s. the causative agen ...	1980	6449122
[biological properties of the strains f. tularensis isolated in slovakia (author's transl)].		1980	6448103
[examination of a natural tularemia focus in the crimea using a passive hemagglutination reaction system].		1980	6445649
a monoclonal antibody specific for the a antigen of brucella spp.	two murine monoclonal antibodies of the igg3 class have been isolated after immunization with brucella abortus. an indirect immunofluorescence test was used to screen hybridoma supernatants and subsequently to determine the cross-reactivity of the monoclonal antibodies with other bacteria. one monoclonal antibody reacted with all the smooth brucella biotypes tried and with yersinia enterocolitica serogroup 0:9, though not with rough br. ovis or with strains of escherichia, proteus, salmonella, p ...	1984	6438272
outbreak of tick-borne tularemia--south dakota.		1984	6434937
serologic studies on brucellosis, leptospirosis and tularemia in moose (alces alces) in quebec.	blood samples were obtained from 208 moose in la vérendrye and matane reserves and in laurentides park, quebec, canada. sera were tested for antibodies to brucella abortus, leptospira interrogans serovar ballum, canicola, grippotyphosa, hardjo, icterohaemorrhagiae and pomona, and francisella tularensis. fifteen sera contained evidence of prior exposure to f. tularensis. only one animal was a seroreactor to l. interrogans serovar grippotyphosa and none of them had antibodies to b. abortus.	1984	6429355
comparison of the effects of acid and base hydrolyses on hydroxy and cyclopropane fatty acids in bacteria.	the cellular fatty acid compositions of legionella oakridgensis, brucella suis, pseudomonas aeruginosa, and francisella tularensis were compared after base hydrolysis (saponification), acid hydrolysis, and acid methanolysis procedures were used to release the fatty acids. the branched-chain, unsaturated, saturated, and ester-linked hydroxy acids were released as effectively with saponification at 100 degrees c for 30 min as with acid hydrolysis or acid methanolysis at 85 degrees c for 16 h. alth ...	1983	6418758
[new developments in the study of natural tularemia foci in the ussr].		1984	6397015
persistence of francisella tularensis mccoy et chapin tularemia agent in the organism of highly sensitive rodents after oral infection.	in the literature there are no data on the possibility of obtaining in experiment non-fatal tularemia infection (persistence) in rodents highly sensitive to it (group i) when using highly virulent strains circulating in nature for infection by natural routes. our detailed experiments on 1483 adult voles microtus rossiaemeridionalis ogn. (syn. m. subarvalis meyer et al.) of laboratory origin using virulent strains of francisella tularensis holarctica ols. et meshch. and natural alimentary infecti ...	1984	6396330
an endemic case of tularemia in the mountain hare (lepus timidus) on the island of stora karlsö.	in september 1983, an epizootic of unknown cause broke out among the mountain hares on the island of stora karlsö, which is located outside the coast of gotland. one hare was sent in the national veterinary institute for post-mortem examination. the hare showed lesions in liver, spleen, and bone-marrow typical for tularemia. the specimens were positive for francisella tularensis with fluorescent-antibody test. tularemia has not been observed earlier in this part of sweden. it is supposed that th ...	1984	6393050
quantum differences in oral susceptibility of voles, microtus pennsylvanicus, to virulent francisella tularensis type b, in drinking water: implications to epidemiology.	shedding nephritis in voles with chronic tularemia is the probable source of frequent contamination of streams over wide areas of the northern hemisphere. however, voles inoculated parenterally with as few as one dex viable cells of francisella tularensis palaearctica succumb uniformly to acute tularemia, whereas voles, beavers, and muskrats often thrive in waters contaminated with the organism. nevertheless, water-borne epizootics do occur in these animals, and at these times streams are heavil ...	1983	6381031
[determination of tularemia antibodies by an immunoenzyme method on a solid-phase carrier (elisa)].	elisa "sandwich" techniques have been developed and the optimum assay conditions for detecting specific antibodies in human serum samples have been determined. the possibility of using these techniques for the determination of the level of antibodies to tularemia antigens in the sera of persons immunized with live tularemia vaccine has been shown. statistically significant differences in the level of antibodies to tularemia antigen in the sera of immunized and nonimmunized persons have been esta ...	1984	6377770
tularemia in children.		1983	6361709
landmark perspective: tularemia.	the landmark studies on tularemia by dr francis have been recognized by designating the causative organism francisella tularensis rather than bacterium tularense. a review of his original 1925 article clearly demonstrates the lasting value of critical clinical, epidemiologic, and laboratory studies. except for expansion of knowledge concerning some aspects of the epidemiology and clinical spectrum and advances in treatment and prevention, the 1925 article is as contemporary as the current litera ...	1983	6358566
isolation of francisella tularensis and powassan virus from ticks (acari: ixodidae) in ontario, canada.		1984	6327984
effects of streptococcus pneumoniae, salmonella typhimurium and francisella tularensis infections on oxidative, glycolytic and lysosomal enzyme activity in red and white skeletal muscle in the rat.	since opinions differ as to whether the oxidative and glycolytic capabilities of skeletal muscle are altered in acute infection, enzyme activities in oxidative, glycolytic and degradative (acid hydrolases) pathways and total protein and dna were determined in skeletal muscle of rats infected with streptococcus pneumoniae, salmonella typhimurium or francisella tularensis. studies were performed separately in red (slow twitch) and white (fast twitch) muscle tissue because these fibers function dur ...	1984	6320357
a wild and an attenuated strain of francisella tularensis differ in susceptibility to hypochlorous acid: a possible explanation of their different handling by polymorphonuclear leukocytes.	we have previously reported that a wild strain of francisella tularensis is much less efficiently killed by human polymorphonuclear leukocytes than is an attenuated strain. in the present study, the killing of the attenuated strain was found to be strictly oxygen dependent. the wild and the attenuated strains both induced a respiratory burst in the leukocytes. the difference between the strains in susceptibility to agents produced at the burst could be explained by a difference in susceptibility ...	1984	6319290
serologic survey for selected microbial agents in mammals from alberta, 1976.	blood samples were taken from humans and several species of free-ranging wild mammals from five different geographic areas of alberta, canada. sera were tested for antibody to eastern equine encephalitis (eee) virus, western equine encephalitis (wee) virus, st. louis encephalitis (sle) virus, powassan (pow) virus, the snowshoe hare (ssh) strain of the california group (cal) of viruses, northway (nor) virus, klamath (kla) virus, infectious bovine rhinotracheitis (ibr) virus, and two bacteria, bru ...	1981	6273600
[tularemia on the kola peninsula].	in 1982 francisella tularensis was isolated for the first time on the kola peninsula from rodents caught in the environs of kirovsk and nickel. this fact confirmed the suggestion concerning the existence of the natural foci of tularemia on the kola peninsula.	1984	6241403
[focal nature of tularemia along the course of the irtysh-karaganda canal].	the results of the epizootological survey of the track of the irtysh-karaganda canal for tularemia for the period of 1971-1982 are presented. out of 928 fecal samples from mouse-hunting birds, 16 contained the specific antigen. from arctic shrews a strain of francisella tularensis was isolated.	1984	6240873
[detection of the tularemia zoonosis in the territory of the kartlian plain].	the natural focus of tularemia was found to cover the whole territory of the kartlian plain. epizooty occurred mainly among common voles with the involvement of insectivorous voles. hard ticks, gamasids and fleas infected with francisella tularensis were detected. rodents highly sensitive to tularemia can be affected by this infection. water rats were not involved into the enzootic process. further studies are necessary for the final solution of this problem.	1983	6225274
[biological characteristics of spectinomycin-resistant strains of the tularemia pathogen].	sensitivity of 2 subspecies of the tularemia causative agent to spectinomycin, an aminoglycoside antibiotic, was studied in vitro. the mic of the antibiotic with respect to strains 503/847 and schu was 40 micrograms/ml and with respect to strain a-cole 20 micrograms/ml. the frequency of spontaneous spectinomycin resistant mutants was low. the mutants grown on a medium containing spectinomycin in a concentration of 100 micrograms/ml were highly resistant to the antibiotic (at least 10000 microgra ...	1983	6224461
[culture properties of the causative agent of tularemia isolated in natural foci in stavropol territory, the kalmyk assr and the armenian ssr].	the strains isolated in natural foci of the stavropol territory and the armenian ssr have been found to belong to the holarctic race of francisella tularensis, biovar ii. in natural foci of the kalmyk assr the strains belonging to biovars i and ii have been isolated. the study of the tularecinogenicity of the cultures has revealed the existence of strains which are not sensitive to their own tularecins. the phenomenon of tularecinogenicity in f. novocida has been established. avirulent strain 31 ...	1983	6220538
[results of prolonged study of flood plain-swamp endemic foci of tularemia, and its prophylaxis in the leningrad region].	the results of a prolonged (more than 18 years), comprehensive study have revealed that stable natural foci of tularemia in backwater swamps are widely spread in the leningrad region. these foci are located in the narrow swampy flood-plains of small watercourses with adjacent meadow areas among forests. water from such small watercourses can often serve as the indicator of the epizootic process: during the above-mentioned period 346 francicella tularensis strain have been isolated from water and ...	1982	6211873
[activation of natural tularemia foci of the field-meadow and steppe types on the territory of tula province 1977-1978].	natural tularemia foci of the meadow and steppe type are extremely stable and become active in those years when the most favourable living conditions for rodents appear. for the first time during the last 30 years a great increase in the number of common voles, accompanied by widely spread epizooty covering the whole territory of the tula region, was observed. house mice, common field mice, harvest mice and black rats were also involved in this epizooty and 235 tularemia patients with all clinic ...	1982	6211008
antigen from francisella tularensis: nonidentity between determinants participating in cell-mediated and humoral reactions.	after tularemia vaccinations, most individuals respond with cell-mediated and humoral immunity as disclosed by the lymphocyte stimulation test and enzyme-linked immunosorbent assay (elisa), respectively. there is, however, no correlation between the magnitudes of the two responses, and some individuals show one of the responses only. we now report that the two responses are directed towards different antigenic determinants of the bacterium. ether-water extraction of the live vaccine strain of fr ...	1984	6203835
evaluation of a safranin-o-stained antigen microagglutination test for francisella tularensis antibodies.	a microagglutination test for francisella tularensis, with 0.025-ml amounts of diluted sera and 0.025-ml amounts of safranin-o-stained antigen in u-bottom microtitration plates, was compared with a tube agglutination test by using 137 sera. there was 86.3% agreement (+/- 1 dilution variation) between the microagglutination results and the tube agglutination results for sera with tube agglutination titers of greater than or equal to 20. there was 100% agreement (+/- 1 dilution variation) for sera ...	1980	6153660
antigenic composition of a vaccine strain of francisella tularensis.	the antigenic composition of the live vaccine strain of francisella tularensis was investigated. ether-water extracts, water-soluble material from freeze-pressed bacteria and detergent-eluted material from bacterial envelope were allowed to react in immunodiffusion and immunoelectrophoresis with rabbit antiserum against disintegrated bacteria of the vaccine strain. ten antigenic factors were distinguished in an ether extract. when the extract was precipitated with ammonium sulphate 15 antigenic ...	1980	6153169
influence of sublethal x-irradiation on immuity of guinea pigs administered live tularemia vaccine.		1967	6079921
[isolation of p. tularensis from reservoir animals on artificial culture media].		1967	6077066
the relationship between immune response and hydrolase activity in rat mononuclear leucocytes.		1967	6036883
phagocytosis and intracellular fate of pasteurella tularensis: in vitro effects of exudate stimulants and streptomycin on phagocytic cells.		1967	6030546
response of guinea pig to sublethal x-irradiation and live tularemia vaccine.		1967	6024840
capillary agglutination test for pasteurella tularensis antibodies.		1967	6019708
[experimental inhalation tularemia].		1966	6005090
[a study of a virulent strain of f. tularensis in tissue culture in vitro].		1966	6004972
[photometric analysis of bacterial suspensions. iv. on the possibility of using the osmotic effect to determine the relationship between live and dead cells in suspensions of tularemia bacteria].		1966	6004727
[on a study of strains of the tularemia microbe isolated in the south of europe].		1966	6003714
[further studies on the relationship: brucellae and francisella tularensis].		1966	5991179
[further immunological studies of brucellae and of fr. tularensis: sugar components-serological analysis].		1966	5991178
modified agglutination test for pasteurella tularensis.	several modifications in technique were incorporated into the standard agglutination test for pasteurella tularensis. reciprocal shaking of all tubes in a kahn shaker was introduced to increase the rate of agglutination and quantity of agglutinated cell mass, making it possible to report preliminary results within 4 hr. increased incubation time at a higher temperature was used to favor the rate of agglutination. a serum control for each serum tested was necessary to detect false positive tests. ...	1966	5959860
an outbreak of human tularemia associated with the american dog tick, dermacentor variabilis.		1966	5949558
[first cultivation of p. tularensis from pathological material of human origin on a new liquid thioglycolate medium].		1966	5945202
histobacteriology of the genus pasteurella ii. specificity and stability of the various species of pasteurella.		1966	5944883
[immunologic and antigenic relations between parvobacteriaceae: brucella and francisella tularensis].		1966	5934176
[the use of new media in the cultivation of pasteurella tularensis].		1966	5926718
in vitro interactions between rabbit alveolar macrophages and pasteurella tularensis.	nutter, j. e. (fort detrick, frederick, md.), and q. n. myrvik. in vitro interactions between rabbit alveolar macrophages and pasteurella tularensis. j. bacteriol. 92:645-651. 1966.-rabbit alveolar macrophages were successfully employed in a study of host cell-pasteurella tularensis interactions in vitro. under cell culture conditions in which inhibitory antibiotics were not employed and small infection ratios were used, the relative in vivo virulence of two strains of p. tularensis was duplicat ...	1966	5922539
respiratory antibody to francisella tularensis in man.		1966	5917335
[duration of preservation and localization of the causative agent of tularemia in the organism of experimentally infected sheep].		1965	5895077
[on the determination of natural carrier state of the tularemia causative agent in hirstionyssus musculi johnston ticks].		1965	5887754
[changes of certain biological properties of pasteurella tularensis exposed to repeated freezing and thawing].		1965	5877976
[the droplet method of indirect hemagglutination reaction with the tularemia antigen].		1965	5873583
biochemical studies of metabolic relationships in tularemia.		1965	5845291
susceptibility to infection with pasteurella tularensis and the immune response of mice exposed to continous low dose rate gamma radiation.		1969	5822617
francisella tularensis in new england.		1969	5814146
pathological changes in rabbits injected with pasteurella tularensis killed by ionizing radiation.		1969	5795104
[a clear nutrient medium for fr. tularensis].		1969	5790213
interacting factors that influence long-term storage of live pasteurella tularensis vaccine and rift valley fever virus.	studies were conducted on the interaction of various parameters which affect the storage stability and growth potential of liquid cultures of pasteurella tularensis live vaccine strain (lvs) and rift valley fever virus van wyk strain (rvfv). storage variables studied with lvs included four storage temperatures (4, -20, -65, -175 c), single and multiple freeze-thaw cycles, two freezing and two thawing rates (slow and fast), various inoculum levels (1, 3, 5, and 10%) for the determination of growt ...	1969	5780399
notes on pasteurella tularensis isolated from a vole, microtus oeconomus pallas, in alaska.		1969	5765177
[citrulline ureidase activity in geographical races of francisella tularensis].		1968	5745533
[the antibody neutralization test in tularemia].		1968	5735231