Publications

esterase activity of zinc neutral proteases.	the hydrolysis of a series of depsipeptides demonstrates that the zinc neutral endopeptidases of bacteria are active esterases. esters such as bzgly-ophe-ala, bzgly-oleu-ala, and fa-gly-oleu-nh2 are hydrolyzed at rates three- to eightfold slower than are their exact peptide analogues, when hydrolyzed by thermolysin, bacillus subtilis neutral protease and the neutral protease from aeromonas proteolytica. ester hydrolysis by zinc neutral proteases follows the characteristic preference for hydropho ...	1976	2276
acute myocardial infarction and ischemic injury during surgery for coronary artery disease.	the incidence of myocardial infarction, acute ischemic injury, and associated serum enzyme abnormalities has been evaluated in four operations involving the coronary circulation. the highest incidence of infarction was associated with internal mammary implantation (vineberg procedure). there was no significant difference in the incidence of infarction, ischemic injury, or abnormal enzyme levels between patients with stable angina and those with unstable angina who had vein bypass surgery. in ope ...	1999	18002
quantitative characteristics of the feyrter (apud) cells of the neonatal rabbit lung in normoxia and chronic hypoxia.	our studies show that the apparent number of feyrter cells in the lung declines during the neonatal period in normoxic rabbits, and that in hypoxic animals a uniformly and significantly lower number of cells occurs as compared with the normoxic rabbits. there is some indication of degranulation of cells in the hypoxic groups. it is suggested that environmental and/or physiological factors associated with the start of extrauterine life, or lung development, may affect the apparent number and prob ...	1977	22136
retinol-binding protein in malnutrition.		1999	90984
epileptogenic effect of mianserin.		1999	91069
on the reaction of iron bleomycin with thiols and oxygen.		1999	91373
tetralogy of fallot in adults.		1999	91440
steroids in asthma.		2000	91910
response to immunological or cholinergic stimulation of isolated mast cells from man, guinea pig and rat.		1979	91954
[cutaneous leishmaniasis. alcoy: an endemic zone].		1979	92178
[effect of pindolol on tachycardia and certain metabolic variations dependent of muscular exertion].	1. -- in young well trained adults, adrenergic beta receptors blockade by pindolol or propranolol causes a relative bradycardia during running on a threadmill during 10 to 20 min at 50% vo2 max. 2. -- pindolol activity is maximum for 5-7.5 mg ingested one hour before starting. in two subjects, tachycardia reappears for 30 mg : this secondary increase may be explained by an intrinsic sympathetic activity of pindolol. 3. -- propranolol is about 14 times less active than pindolol without any intrin ...	2000	92294
[effect of ergoline derivatives on platelet and blood vessels].	the influence of dihydrogenated ergot alkaloids on vessels and blood platelets was studied in vitro and in vivo. at low concentrations they cause contraction of isolated vein strips via a stimulation of alpha-adrenoceptors, at higher concentrations they antagonize the action of noradrenaline on arteries and veins and inhibit the adrenaline-induced platelet aggregation in vitro. in volunteers, intravenous and subcutaneous administration of dihydroergotamine (dihytamin) caused a decrease in blood ...	1979	94864
analytical separation of bleomycin.		2001	94911
[biliary tract atresia].		2000	97569
[immunological relations between mother and child during pregnancy (author's transl)].	the relations between the maternal and foetal organisms during pregnancy are partly very complicated and remain inexplicable. blastocyst, trophoblast, embryo and foetus have membrane antigens at a very early stage, and the immunocompetence of the foetus develops already during the second third of the pregnancy period. many non-specific factors are involved in preventing the castingoff reaction of the foetal organism. the trophoblastic tissue is probably of central importance. the focal point of ...	1978	98927
[enlarge indications for controlled respiration (author's transl)].	controlled respiration should have a place not only in cases of hypoventilation but also in the treatment of comatose and hyperventilating persons. hyperventilation is liable severely to interfere with the blood supply to the brain, and this disturbance, in conjunction with the primary disease responsible for the comatose condition, such as hyperglycaemia, diabetes or cerebral trauma, may be a contributing factor to the lethal outcome. controlled respiration helps towards regulation of the cereb ...	1999	99735
fetal heart rate during a maternal grand mal epileptic seizure.	although maternal ingestion of antiepileptic drugs is strongly suspected of causing congenital defects, particularly oral clefts, the effect of epilepsy itself or a combined effect of drug intake and epilepsy have not been excluded as etiological factors. very little is known about fetal oxygenation during a maternal grand mal epileptic seizure. we describe two cases in which fetal heart rate was recorded during a maternal epileptic seizure during labor. the first fetus became clearly asphyctic ...	1998	106102
effects of morphine withdrawal on food competition hierarchies and fighting behavior in rats.		1979	106426
interaction of amino acids with glycl-l-leucine hydrolysis and transport in monkey small intestine.	1. there are two saturable transport processes in the monkey small intestine for glycyl-l-leucine, one with vmax. 1 mumol min-1 g-1 wet weight of tissue and an affinity constant (kt) of 5 mmol/l, and the other with vmax 3.9 mumol min-1 g-1 wet weight of tissue and kt 33 mmol/l. 2. glycyl-l-leucine uptake is inhibited by a wide variety of amino acids, although to a variable extent. the inhibition was shown to be competitive with leucine used as the representative amino acid. phenylalanine, methio ...	1979	117966
evidence for the subcellular localization and specificity of chlordane inhibition in the marine bacterium aeromonas proteolytica.	sublethal levels (10 to 100 micrograms/ml) of the chlorinated insecticide chlordane (1,2,4,5,6,7,8,8-octachloro-3a,4,7,7a-tetrahydro-4,7-methanoindan) were introduced into the growth medium of the marine bacterium, aeromonas proteolytica. chlordane inhibited the synthesis of an extracellular endopeptidase by almost 40% but exhibited no such inhibition of the extracellular aminopeptidase also produced during the growth cycle. studied with 14c-labeled chlordane demonstrated that the insecticide wa ...	1979	156517
organ cultures of rat and hamster colon.	human fibrin foam as a matrix for three-dimensional organ cultures was successfully employed for the cultivation of newborn rat and hamster colon tissue. colonic tissue was maintained under different oxygen atmospheres and with various synthetic media. explants of rat and hamster colon, maintained in leibovitz's l-15 medium buffered with hepes in the presence of 5% co2 and air, retained their normal columnar epithelial architecture for 24 days in culture. outgrowth of epithelial cells from colon ...	1975	165141
[increased camp concentration in parotid secretion in arterial hypertension: relationship to plasma-renin activity (author's transl)].	hypertensives with normal and increased plasma-renin activity have an increased salivary excretion of cyclic adenosine monophosphate (camp) such as can be obtained in normal persons by stimulation of beta-adrenergic fibres. propanolol, as a beta-receptor blocker, reduces such increased camp levels in hypertensives to minimal levels. the results suggest that beta-receptors are stimulated in hypertensives with normal or increased renin activity.	1996	168050
conformation of l-cystathionine, a carba analog of cystine, and stereochemistry of hormone-receptor interactions.	the conformation of l-cystathionine, a carba analog of l-cystine, has been studied in the solid state using x-ray diffraction techniques. crystal of l-cystathionine are tetragonal, space group p41 with cell constants a = 6.691(1) a, c = 21.998(3) a and z = 4. from diffractometer data to the limit of 2theta = 162 degrees for cukalpha, the structure was refined using full-matrix least-squares to an r value of 0.061. l-cystathionine is isostructural chemically to l-cystine and its crystal structure ...	2003	203329
managing metastatic breast cancer: a point of view.		1979	218377
hyponatremic syndromes.		2004	368447
homogeneous immunoglobulins in the serum of irradiated and bone marrow reconstituted mice: the role of thymus and spleen.	the influence of thymectomy and splenectomy on the frequency and class distribution of homogeneous immunoglobulins (h-ig) in serum was studied in lethally irradiated (dba/2 x c57bl/rij)f1 mice reconstituted with syngeneic bone marrow. during four follow-up periods in the first 9 months after transplantation, the sham-operated controls and splenectomized animals developed transient h-ig in an average frequency of 14.2 and 15.7% respectively. there were no marked differences in the incidence of h- ...	2004	387578
physiological responses of bacteria to cytochalasin a: effects on growth, transport, and enzyme induction.	cytochalasin a at 5 to 25 microgram/ml (1.0 x 10(-5) to 5.2 x 10(-5) m) inhibited the growth of three gram-positive bacteria, arthrobacter sialophilus, staphyloccus aureus, and bacillus amyloliquifaciens, but had little or no effect on the growth of three gram-negative bacteria, excherichia coli, pseudomonas maltophilia, and aeromonas proteolytica. a. sialophilus and s. aureus recovered spontaneously from cytochalasin a-mediated growth inhibition after a considerable lag period, which was depend ...	1979	422516
a simple centrifuge column for desalting protein solutions.		2005	543535
superactivation of neutral proteases: acylation with n-hydroxysuccinimide esters.	a series n-hydroxysuccinimide esters of acylamino acids previously shown to acylate and thereby increase the activity of thermolysin by several orders of magnitude (blumberg, s., and vallee, b. l. (1975), biochemistry 14, 2410) has been used to modify the related neutral proteases from bacillus subtilis, bacillus megaterium, and aeromonas proteolytica. each of these enzymes is activated to a level characteristic of the particular protein and the particular acyl group incorpporated when monitored ...	1976	823965
aeromonas proteolytica--a halophilic aeromonad?	aeromonas proteolytica, a halophilic bacterium originally isolated from the intestine of a marine isopod, was compared with 93 strains of aeromonas hydrophila and representative strains of five similar genera in a computer and serological analysis. aeromonas proteolytica was peritrichate and non-reactive with six a. hydrohila antisera, and possessed a percentage guanine + cytosine ratio (49.5) outside the range for other aeromonads (55-62%). moreover, in the computer analysis it shared a lower l ...	1975	1148936
serum amylase changes during pregnancy.	study of the behavior of serum amylase activity in 200 preganant women in various stages of pregnancy indicated that: (1) serum amylase rises gradually during pregnancy until the twenty-fifth week and thereafter falls slightly; (2) serum amylase values may be found in normal pregnant women during the second and third trimesters that exceed those in normal men and nonpregnant women; (3) during the second trimester of pregnancy there may be an alteration in the relative distribution of the pancrea ...	2005	1168998
[ventricular fibrillation during testing of a demand pacemaker (author's transl)].	ventricular fibrillation was precipitated in a patient with an implanted unipolar demand pacemaker while its function was being tested by switching over to a fixed-rate output by means of a magnet. there was no evidence of either myocardial infarction, abnormal electrolyte state, or digitalis intoxication. this, probably unique, case indicates that non-synchronized stimulation, even during brief switching over of a demand pacemaker to a fixed-rate one, may endanger the patient.	2005	1183358
the amino acid sequence of the tryptic peptides isolated from dogfish m4 lactate dehydrogenase.	the peptides which result from treatment of the s-[14c]carboxymethyl derivative of dogfish m4 lactate dehydrogenase (ec 1.1.1.27) with trypsin have been isolated and their sequences have been elucidated. each identical subunit has a molecular weight of 36,000 and on the basis of the amino acid composition 40 unique tryptic peptides are anticipated. thirty-seven of these peptides have been isolated and have been completely characterized. the amino acid sequences of these peptides are presented.	2005	1184589
myoid cells in the peritubular tissue (lamina propria) of the reptilian testis.	the arrangement and fine structure of peritubular myoid cells was studied in the testes of three species of reptiles (lacerta dugesi, testudo graeca and natrix natrix) during two short periods of the seasonal cycle (european spring and autumn) and correlated with some ultrastructural properties of leydig cells. the lamina propria consists of myoid cells, fibroblasts and non-cellular components comprising collageneous and non-striated microfibrils. both components are arranged in alternating laye ...	2005	1201592
[salmonellosis carrier state].		1975	1214656
[the health check-up in industrial medicine].		2000	1221296
[indications for mediastinoscopy].	mediastinoscopy is a surgical examination exploring the anterior and superior mediastinum for diagnosing and localizing lesions, after taking such precautions as the elimination of vascular lesions. the indications are : interbronchial and intertracheobronchial opacities ; polylobulated mediastinal opacities ; the isolated opacity (in case of inconclusive mediastinoscopy, operate straight away) ; pulmonary lesions : to look for mediastinal node untraceable on x-ray. in the particular case of a b ...	2004	1223840
characterization of a pollen-specific cdna from sunflower encoding a zinc finger protein.	we have isolated, via differential hybridization screening of a floral cdna library from sunflower, a cdna clone that hybridizes to a 1100 nucleotide-long mrna found exclusively in mature pollen grains. the cdna encodes a 219 amino acid-long polypeptide containing two potential zinc fingers alternating with two basic domains. a similar organization is found in the erythroid-specific transcription factor eryf1 from chicken and its murine homolog gf-1. the c-terminus of the protein contains a sixf ...	1992	1302629
towards a phylogeny of the genus vibrio based on 16s rrna sequences.	the inter- and intrageneric relationships of the genus vibrio were investigated by performing a comparative analysis of the 16s rrnas of 10 species, including four pathogenic representatives. the results of immunological and 5s rrna studies were confirmed in that the genus is a neighboring taxon of the family enterobacteriaceae. with regard to the intrageneric structure, vibrio alginolyticus, vibrio campbellii, vibrio natriegens, vibrio harveyi, vibrio proteolyticus, vibrio parahaemolyticus, and ...	1992	1371064
equine herpesvirus 1 glycoprotein d: mapping of the transcript and a neutralization epitope.	studies with molecular and immunological techniques identified and mapped the transcript encoding glycoprotein d (gd) of equine herpesvirus 1 kya, as well as two continuous gd antigenic determinants. three mrna species of 5.5, 3.8, and 1.7 kb overlap the gd open reading frame and are transcribed from the dna strand encoding gd. northern (rna) blot hybridization with both dna clones and riboprobes, as well as s1 nuclease analyses, showed the 3.8-kb mrna to encode gd and to be synthesized as a lat ...	1992	1383565
"secondary" and drug-induced mood, anxiety, psychotic, catatonic, and personality disorders: a review of the literature.		2006	1422165
[effect of peptides of the tracheal mucosa and vascular wall in acute hyperoxic lung injury].	it was demonstrated that peptides of the tracheal mucosa (ptm) and peptides of the vascular wall (pvw) produce a certain protective effect in hyperoxic lung injury. the peptides, (ptm to a greater measure) prolonged the survival of mice and inhibited the dynamics of the growth of the lung coefficient in rats. ptm reduced the formation of malonic dialdehyde and increased the activity of glucose-6-phosphate dehydrogenase in the lungs. morphometric studies showed that ptm produce a more marked inhi ...	1992	1480431
oscillatory potentials, retinopathy, and long-term glucose control in insulin-dependent diabetes.	the main objective of the study was to assess effects of long-term lowering of glucosylated hemoglobin (hba1%) on neurosensory function in insulin-dependent diabetes. individual (op-1, op-2, op-3) and summed (op-sum) amplitudes of oscillatory potentials (ops) of electroretinography were recorded at study start and 7-years later in 45 patients (the oslo study). as an overall 7-year change, amplitudes of op-2, op-3 and op-sum were reduced (p < 0.0001-0.01), retinopathy worsened (p = 0.005), intrao ...	2006	1488874
[nsf (norwegian nurses' association) with its own specialist accreditation].		2006	1489603
isolation and characterization of the hupa gene coding for hu of aeromonas proteolytica.		1992	1508695
dna synthesis decline involved in the developmental arrest of the limb buds in the embryos of the slow worm, anguis fragilis (l.).	the present study was carried out to try and detect the biochemical mechanism involved in the developmental arrest of the limb bud in a serpentiform reptile. autoradiograpy, following tritiated thymidine incorporation, in embryos of the slow-worm (anguis fragilis, l.) reveals a strong decrease in the rate of dna synthesis in the mesodermal cells of the limb bud, after the degeneration of the apical ectodermal ridge (aer); the curve (a function of gompertz) visualizing this decline shows that the ...	2006	1525018
rapid purification of the aeromonas proteolytica aminopeptidase: crystallization and preliminary x-ray data.	the heat-stable aminopeptidase from aeromonas proteolytica has been purified using two new procedures, with the aim of preparing large single crystals for x-ray analysis. in a first procedure, we tried to avoid any drastic conditions capable of inducing microheterogeneities in the protein sample. the enzyme was purified through two chromatographic steps based on hydrophobic interactions and ion exchange. in a second procedure a heat treatment of the protein to a temperature of 70 degrees c over ...	1992	1550363
cloning, sequencing and expression of the gene encoding the extracellular neutral protease, vibriolysin, of vibrio proteolyticus.	the gene (nprv), encoding the extracellular neutral protease, vibriolysin (nprv), of the gram- marine microorganism, vibrio proteolyticus, was isolated from a v. proteolyticus dna library constructed in escherichia coli. the recombinant e. coli produced a protease that co-migrated with purified neutral protease from v. proteolyticus on non-denaturing polyacrylamide gels, and that demonstrated enzymatic specificity towards the neutral protease substrate n-[3-(2-furyl)acryloyl]-l-alanylphenylalani ...	1992	1551587
isolation of the leucine aminopeptidase gene from aeromonas proteolytica. evidence for an enzyme precursor.	the leucine aminopeptidase of aeromonas proteolytica (ec 3.4.11.10) is a monomeric metalloenzyme having the capacity to bind two zn2+ atoms in the active site. structural information of this relatively small aminopeptidase that could illuminate the catalytic mechanism of the metal ions is lacking; hence, we have obtained sequences from the purified enzyme, cloned the corresponding gene, and expressed the recombinant protein in escherichia coli. the deduced primary amino acid sequence of this sec ...	1992	1569090
cloning and nucleotide sequence of the vibrio proteolyticus aminopeptidase gene.	the gene encoding the vibrio proteolyticus aminopeptidase was cloned and sequenced and its amino acid sequence was deduced. the gene encodes a 54 kda protein, larger than the previously reported size of 30 kda for the purified aminopeptidase. sequence alignments revealed a 43-45% homology with two other vibrio sp. extracellular proteinases.	1992	1627651
tenascin expression in the human endometrium and in endometrial adenocarcinomas.	to investigate the involvement of tenascin, an extracellular matrix glycoprotein, in epithelial growth and malignancy, its specific distribution pattern in the human uterus was examined immunohistochemically. during the proliferative phase of the menstrual cycle, this antigen was found as a sharp band around the endometrial glands. the immunoreactivity persisted until the early postovulatory phase of the menstrual cycle, but was not detectable in the glandular or stromal compartment during this ...	1990	1694256
effects of converting-enzyme inhibition on barrier function in diabetic glomerulopathy.	differential solute clearances were used to examine the effects of a 90-day course of enalapril on glomerular barrier function in 16 proteinuric patients with diabetic glomerulopathy. by day 90, plasma renin and prorenin became elevated, and arterial pressure declined. transglomerular passage of dextrans of broad size distribution (radii 28-60 a) was lowered significantly. in a subset of 8 patients, withdrawal of enalapril was followed after an additional 30 days by a return of renin levels and ...	2006	1698674
structure of the rabbit phospholamban gene, cloning of the human cdna, and assignment of the gene to human chromosome 6.	we have isolated and characterized genomic dna clones encoding rabbit phospholamban. only a single gene for phospholamban was detected in the rabbit genome. the phospholamban gene of 13.2 kilobases contains only one 10.5-kilobase intron, which separates exonic sequences located in the 5'-untranslated region. two potential transcription initiation sites were mapped to 335 and 185 nucleotides upstream from the translation initiation site in the mrna or 239 and 89 nucleotides upstream from the exon ...	1991	1828805
complexity and sequence identification of 24 rat v beta genes.	twenty-four tcr v beta genes were cloned by anchored pcr from the lewis rat strain and identified by nucleotide and amino acid sequence comparisons to known mouse v beta genes. rat v beta genes exist in 17 single-member and 3 multimember subfamilies and exhibit 86 to 94 and 72 to 92% nucleotide and amino acid sequence similarities, respectively, to their mouse counterparts. a single rat gene, designated v beta 20, having no previously known mouse counterpart was identified; a closely related gen ...	1991	1828824
utility of leopold maneuvers in screening for malpresentation.	malpresentation is a common complication of pregnancy. using ultrasound as the gold standard, we prospectively tested leopold maneuvers as a screen for nonvertex presentation in the third trimester. in our hands this technique performed poorly. values for sensitivity, specificity, positive predictive value, and negative predictive value were 28, 94, 24, and 95%, respectively, in a population with a 7% prevalence of noncephalic presentation. much of the correlation between the screening and diagn ...	2007	1876372
genes coding for integration host factor are conserved in gram-negative bacteria.	a genetic system for the selection of clones coding for integration host factor and hu homologs is described. we demonstrate that the hima and hip genes of serratia marcescens and aeromonas proteolytica can substitute for the escherichia coli genes in a variety of biological assays. we find that the sequence and genetic organization of the hima and hip genes of s. marcescens are highly conserved.	1991	1917861
measurement of sensitivity to adriamycin in hybrid spheroids.	using the newly developed hybrid spheroid system, we have been able to measure sensitivities to adriamycin in two sublines of lovo cells (a human colon adenocarcinoma line). hybrid spheroids are composed of coagglomerated lovo cells, and nonproliferating hela "feeder" cells, mimicking a population of minitumors. spheroids of uniform size, but containing different numbers of lovo cells, were incubated with various concentrations of adriamycin and after washing, plated for colony formation. binomi ...	1991	1933483
amniotic fluid bilirubin and fetal hemolytic disease.	six different methods for assessing amniotic fluid bilirubin were compared in 111 samples from 37 patients. when the liley methods were compared, the chloroform extraction and 5% correction methods resulted in 20% and 4% reductions, respectively, in the mean change in optical density at 450 nm when compared with the uncorrected mean (0.086 +/- 0.06 [p less than 0.05] and 0.104 +/- 0.07 [p, not significant] vs 0.108 +/- 0.08). this reduction was observed in spite of significant visual blood conta ...	2005	1951508
contaminated origin of aids viruses.		2007	2034269
immunofluorescence demonstration of digoxin in human myocardial tissue and isolated rat cardiac myocytes with monoclonal antibodies.	the aim of the present investigation was to identify the morphological correlates of digoxin binding sites in human heart muscle tissue and isolated viable rat heart myocytes. cardiac glycoside linked to myocardial cells was demonstrated by monoclonal digoxin specific antibody and by fitc-conjugated anti-mouse immunoglobin serum. this versatile immunofluorescence method can be used in diagnostic and experimental studies of cardiac glycoside binding.	1990	2227731
[prevalence of ascariasis and giardiasis in children from 0 to 3 years old hospitalized in the years 1980-1984 and in 1987].	the studies were carried out for six years (1980 - 1984 and in 1987) considering the frequency of invasion by a. lumbricoides and g. intestinalis in various years depending on age and sex. the clinical material involved 5948 children of either sex aged from 0 to 3 years. ascariasis was found in 123 children (2.06%) and giardiasis in 54 cases (0.9%). the infestation was more frequent in boys and it was associated always with other diseases.	2008	2267794
the san diego county medical services program.		2004	2279930
the unique stability of vibrio proteolyticus neutral protease under alkaline conditions affords a selective step for purification and use in amino acid-coupling reactions.	a procedure is described for the purification of a neutral protease from fermentation broths of vibrio proteolyticus. the key feature of the purification scheme is the selective, irreversible inactivation of a contaminating exoenzyme, aminopeptidase, by alkali treatment, rather than removal of this enzyme by conventional chromatographic methods. fermentation broths or concentrates were brought to ph 11.5 to 11.7 by na2co3-naoh addition and incubated at 25 degrees c until aminopeptidase activity ...	1990	2403247
effects of neonatal 6-hydroxydopamine administration on different substance p-containing sensory neurones.	rats were treated neonatally with 6-hydroxydopamine. this resulted in a greater than 93% depletion of noradrenaline content of all tissues examined in adult animals. there was a significant increase in the substance p content of semilunar ganglion, l5 dorsal root ganglion and of sciatic nerve. there was a corresponding increase in substance p synthesis as measured by axonal transport in the sciatic nerve. the noradrenaline content and ratio of noradrenaline: substance p in the iris of control an ...	1987	2442004
evolution and development of the outer acrosomal membrane (oam) and evidence that acrosin-inhibitors are proteins of the oam.	an antiserum to the purified porcine outer acrosomal membrane (oam) was raised in rabbits and the igg fraction isolated by ammonium sulphate precipitation and ion exchange chromatography. the antibodies reacted exclusively with the acrosomal cap of the sperm head as revealed by indirect immunofluorescence. in addition they cross-reacted not only with the acrosomal part of the spermatozoa of all mammalian species tested (bull, horse, rabbit, rat, mouse, hamster, mole, antelope, monkey, man) but a ...	1987	2446533
atrial natriuretic peptide in patients with obstructive uropathy.	renal response to release of bilateral ureteral obstruction resembles that to intravenous administration of atrial natriuretic peptide. in a prospective study we measured plasma atrial natriuretic peptide levels before and serially after relief of obstruction in 9 patients (mean age 65 +/- 2 years old) with bilateral ureteral obstruction and azotemia. obstruction was documented by renal ultrasonography. before relief of obstruction blood urea nitrogen and serum creatinine levels were 85 +/- 18 ( ...	2006	2526230
late appearance of phospholipid platelet-activating factor and leukotriene b4 in human skin after repeated antigen challenge.	inflammatory mediators were assessed in supernatants of chamber fluids from eight ragweed- or grass-sensitive subjects during antigen-induced cutaneous inflammatory responses. platelet activating factor (paf) accumulated at concentrations of 1 pm to 90 mumol/l in six of eight subjects beginning at 3 hours and continuing for 9 hours after antigen challenge. leukotriene b4 (ltb4) was detectable at cutaneous sites of antigen challenge in five of five subjects throughout the 9-hour period at levels ...	1989	2538500
enrolled nurses. we're backing the charter!		2008	2587373
calcium carbonate powder as a phosphate binder.	with increasing recognition of problems regarding the use of aluminum hydroxide as a phosphate binder, calcium carbonate has become the medication of choice. use of calcium has, however, frequently been associated with development of hypercalcemia. at this institution, calcium carbonate powder as a phosphate binder, examination of its efficacy, and the frequency of hypercalcemia with its use were of great interest. calcium carbonate powder (calcarb-hd, 2.4 gms elemental calcium/packet) (calcarb- ...	2006	2597473
endoscopic sclerotherapy for esophago-gastric varices: a critical reappraisal.	amongst the many non-surgical techniques for the treatment of variceal bleeding, endoscopic sclerotherapy (est) has shown great promise. est can successfully obliterate esophageal varices and prevent variceal rebleeding. it is also very effective in the control of active bleeding from esophageal varices. the technique of est is simple and can be carried out with a conventional, forward viewing, flexible endoscope and a teflon injector. weekly intravariceal injections of an aqueous sclerosant are ...	2009	2669716
emerging trends in child abuse and neglect.		2009	2671888
serological cross-reactivity among chlamydial strains in a family outbreak of psittacosis.	three members of a family of nine persons contracted psittacosis with severe pneumonia, respiratory failure, delirium, hepatitis and renal involvement. a newly purchased cockatiel was probably the primary source of infection but person-to-person transmission is likely to have taken place between twin brothers who shared a bedroom, one of whom had no direct contact with birds. type-specific chlamydial serological tests identified the infecting agent as chlamydia psittaci. the highest titres in th ...	1989	2674292
serological cross-reactivity among chlamydial strains in a family outbreak of psittacosis.	three members of a family of nine persons contracted psittacosis with severe pneumonia, respiratory failure, delirium, hepatitis and renal involvement. a newly purchased cockatiel was probably the primary source of infection but person-to-person transmission is likely to have taken place between twin brothers who shared a bedroom, one of whom had no direct contact with birds. type-specific chlamydial serological tests identified the infecting agent as chlamydia psittaci. the highest titres in th ...	1989	2674292
[the use of imaging procedures following kidney transplantation--diagnostic strategy].	despite the continuously increasing number of successfully transplanted kidneys, graft and patient are still "threatened" by several postoperative complications as acute and chronic rejection, acute tubular necrosis, urologic and vascular complications and disorders caused by immunosuppressive medication. an early and safe detection of these conditions is of high clinical importance and a challenge to diagnostic imaging. all radiologic methods and nuclear medicine have their value for transplant ...	2008	2678232
[the use of imaging procedures following kidney transplantation--diagnostic strategy].	despite the continuously increasing number of successfully transplanted kidneys, graft and patient are still "threatened" by several postoperative complications as acute and chronic rejection, acute tubular necrosis, urologic and vascular complications and disorders caused by immunosuppressive medication. an early and safe detection of these conditions is of high clinical importance and a challenge to diagnostic imaging. all radiologic methods and nuclear medicine have their value for transplant ...	2008	2678232
[the value of spinal ct in the planning of spinal surgery].	the diagnostic information gained by spinal ct for the planning of surgery of spinal disease is discussed under clinical aspects. for discogenic disease ct has replaced myelography in significance and as primary investigation, except for unclear complaints, that cannot be attributed to a specific segment. here myelography still is the prime investigation. with ct degenerative peripheral appendages turned out to be significant for secondary stenosis syndromes of the spinal canal. in future it see ...	2008	2678235
sonographic and ct appearance of exogastric leiomyoma.	conventional barium examinations and endoscopy are often inconclusive in patients with subserosal, exogastric leiomyoma. ultrasonography and ct in a patient with a large exogastric leiomyoma revealed a rounded, well-encapsulated tumour with a necrotic cavity centrally. the origin of the tumour from the stomach was demonstrated on both ultrasonography and ct.	2009	2678238
ewing's sarcoma of metacarpal. a case report and review of literature.	the radiological features of a rare case of ewing's sarcoma of right fourth metacarpal in a twenty-five years young male are described. an up date review of literature is also presented.	2009	2698379
[surgical methods in the treatment of patients with acute thrombosis of hemorrhoids].		2008	2699115
[children and domestic fights. a review of 105 social reports].	the object of this investigation was to describe the conditions for children in families with domestic rows on the basis of 105 social reports made by the copenhagen police during a period of one year. a total of 162 children were involved in domestic rows. the typical family had 1-2 children. in 14% of the cases, the domestic rows were reported by the child. in connection with the domestic rows, violence to the women occurred in just under half of the cases and to the children in 6%. in 77% of ...	2009	2711507
collagen accumulation by human mammary epithelial cells in primary culture.		1989	2720795
histamine concentration and ca2+ mobilization in arterial smooth muscle.	smooth muscle contraction is dependent on ca2+ entry from the extracellular space or release from intracellular stores. the sensitivity of these ca2+ sources to agonist concentration was evaluated by measuring myoplasmic [ca2+] (as estimated by aequorin), myosin phosphorylation, and isometric stress in the swine carotid media. high histamine concentrations produced transient elevations in [ca2+] and phosphorylation with rapid generation of near maximal stress. lower histamine concentrations prod ...	1989	2750885
magnetic resonance imaging versus computed tomography of leukocoric eyes and use of in vitro proton magnetic resonance spectroscopy of retinoblastoma.	to evaluate the usefulness of magnetic resonance imaging (mri) in the evaluation of leukocoric eyes, the authors studied 28 patients with either leukocoria or intraocular mass with a 1.5-tesla (t) mri imager. retinoblastomas were reliably distinguished from coats' disease, toxocariasis, and persistent hyperplastic primary vitreous on the basis of mri findings. calcification cannot be reliably detected on mri scans. lesions elevated less than 4 mm may not be detected reliably by mri at this time. ...	2009	2771363
differential adhesion of metastatic rat mammary carcinoma cells to organ-derived microvessel endothelial cells and subendothelial matrix.	the in vitro adhesion rates of rat 13762nf mammary adenocarcinoma cell clones of different spontaneous metastatic potentials to cloned microvessel endothelial cell monolayers and their subendothelial extracellular matrix were investigated. in this system, high rates of adhesion of the cloned tumor cell lines to syngeneic target (lung) organ-derived subendothelial matrix correlated with spontaneous metastatic potential, whereas adhesion to the lung microvessel endothelial cell apical surfaces occ ...	1989	2776962
preparative electrochemical reduction of 2-amino-6-chloropurine and synthesis of 6-deoxyacyclovir, a fluorescent substrate of xanthine oxidase and a prodrug of acyclovir.	d.c. polarography of 2-amino-6-chloropurine in aqueous medium over a broad ph range revealed two diffusion waves, the first of which corresponds to reduction of the c(6)-cl bond, leading to formation of 2-aminopurine in high yield. condensation of the sodium salt of 2-aminopurine with (2-acetoxyethoxy)methyl chloride led to the two isomeric 9- and 7-(2-hydroxyethoxymethyl)-2-aminopurines. the 9- isomer, 6-deoxyacyclovir, a prodrug of acyclovir previously synthesized by another route, was readily ...	1987	2833054
two distinct mechanisms for regulation of gamma-glutamyl transpeptidase in cultured rat hepatocytes by glucocorticoid-like steroids.	adult rat hepatocytes maintained in primary monolayer culture with defined medium were used to characterise two effects of glucocorticoid-like steroids in regulating gamma-glutamyltranspeptidase (ggt). low concentrations of glucocorticoids alone had little effect on ggt but synergistically enhanced induction of the enzyme by liver tumor-promoting xenobiotics such as 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)-ethane (ddt) and hexachlorocyclohexane. the enhancing effect appears to be mediated by the ...	1987	2885003
beta-adrenergic receptor agonist infusion increases plasma prostaglandin f levels in pregnant sheep.	recent evidence of a stimulatory effect of beta-adrenergic receptor agonists on prostaglandin production by human fetal membranes in vitro prompted us to investigate whether prostaglandins are increased during beta-agonist infusion in vivo. on days 120 to 125 of gestation, blood samples were drawn from the aorta and vena cava of five crossbred ewes at 15-minute intervals for 1 hour before, during, and for 1 hour after a 3-hour infusion of isoproterenol (0.16 microgram/kg/min) or normal saline so ...	1987	2890305
dice: nonclinical causes of overtreatment.		2010	2916481
[muscular dystrophy patients and their dental care].		2010	2937973
changes in sebum secretion and the sebaceous gland.	new data have shown that sebum secretion is highest in young adults and then declines steadily throughout life in both men and women. this parallels the decline in androgen levels, but this cannot be the sole factor because there is so much overlap in sebaceous gland activity between men and women. the increased occurrence of dry skin in the elderly has been shown to be unrelated to the sebum secretion rate. this is not unexpected, as children, with even less sebum, rarely have this problem. seb ...	2010	2941202
conversion of estrogen receptor from a state with low affinity for estradiol into a state of higher affinity does not require 4s to 5s dimerization.	this study was undertaken to establish whether the heat-promoted conversion of receptor-estradiol complex (re2) from a state with fast into a state with slow e2 dissociation requires 8s/4s to 5s transformation. the calf uterine estrogen receptor labeled with [3h]e2 at 0 c (state with low affinity for e2) was immobilized on hydroxylapatite (hap) in the absence (8s oligomer) or presence (4s monomer) of 0.4 m kcl and heated at 28 c in the presence of unlabeled diethylstilbestrol. under these condit ...	1985	2981069
[role of virus-induced autoreactive t-lymphocytes, t-suppressors and the serum factor regulating their activity in the pathogenesis of experimental infection caused by the langat virus in mice].	the precursors of autoreactive t-lymphocytes (partl) have been detected in the spleen of mice infected with langat virus. when introduced into syngeneic recipients, partl differentiate in their lymph nodes into autoreactive t-lymphocytes (artl) causing a fatal autoimmune disease in the syngeneic recipients in vivo and capable of destroying syngeneic cell cultures in vitro. in the thymus of mice infected with langat virus t-suppressors (ts) inhibiting the differentiation of partl into artl have b ...	1985	2998127
enhanced replication of murine cytomegalovirus in murine leukemic lymphocytes.	replication in vitro of murine cytomegalovirus was found to be enhanced in lymphoid cells from leukemic (akr/j) mice as compared with similar cells from nonleukemic animals. prolonged productive murine cytomegalovirus infection in lymphoid organs in vivo was demonstrable only in leukemic akr/j mice. latent nonproductive murine cytomegalovirus infection established in young nonleukemic akr/j mice was invariably reactivated and expressed in salivary glands and lymphoid organs after these animals b ...	1986	2998605
[x-ray computed tomography in venous pathology].	after presenting the tomodensitometric semiology of venous thromboses in various territories, the authors define its indications. it is essentially in deep territories, head, chest and abdomen that the ct-scan is used to study and diagnose unrecognized thromboses as well as determine the venous repercussion of various neighboring ailments. the respective place of the ct-scan, ultrasonography and various phlebographies is analyzed.	2011	3043474
the investigation and management of arthropod bite reactions acquired in the home.		1987	3119262
effect of ultraviolet radiation on guinea pig epidermal langerhans cell cytomembrane: light and electron microscopic studies.	the epidermal langerhans cells (elc) are thought to be the outermost station of the immune system. their location in the suprabasal layer of the epidermis makes them susceptible to a continuous exposure to ultraviolet irradiation (uvr) and if uvr alters the elc, this may in turn induce both local and systemic effects. in this paper we have shown that uva and uvb exposure produced dose-dependent changes of elc, characterized by disturbance of spatial distribution and aggregation of the atpase loc ...	1985	3161009
induction of creatine kinase in immature rat uteri by zearalenone, an estrogenic mycotoxin.	intraperitoneal administration of alpha-zearalenone (zen) to female immature rats induced synthesis of a uterine protein which has been identified as creatine kinase. the induced enzyme was purified to homogeneity by chromatography on deae sephacel and hydroxyapatite ultrogel. guinea pig antiserum against estrogen-induced uterine, rat uterine creatine kinase crossreacted with the zen-induced enzyme, indicating that zen exhibits an early estrogenic response in a manner analogous to natural estrog ...	1985	3161514
[morbidity with temporary disability among sailors].		2011	3234781
[intramedullary invasion by a cervical cystic neurinoma--a case report].	this report examines a case involving a huge cystic cervical neurinoma existing extra- and intramedullary. the histogenesis of intramedullary neurinoma, pathohistogenesis of large intratumoral cyst are discussed. the role of magnetic resonance imaging (mri) in the diagnosis of spinal tumors is also discussed. a 23-year-old male was admitted to our ward or having tetraparesis. on admission, spastic tetraparesis and sensory disturbance below level c 2 were noticed. electrophysiological examination ...	2012	3368034
plant glycosides in a liposomal drug-delivery system.	plant glycosides were incorporated into the liposomal surface to study their sugar-specific uptake by various tissues. two steroid glycosides, namely floribundasaponin d, with rhamnose as terminal sugar, and gracillin, with glucose and rhamnose as end sugars, were selected for the purpose. 125i-human igg encapsulated liposomes composed of egg lecithin (phosphatidylcholine), cholesterol, dicetyl phosphate (optional) and either floribundasaponin d or gracillin, when injected into the tail vein of ...	1987	3426542