Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| characterisation of microbial communities within aggressive prostate cancer tissues. | an infectious aetiology for prostate cancer has been conjectured for decades but the evidence gained from questionnaire-based and sero-epidemiological studies is weak and inconsistent, and a causal association with any infectious agent is not established. we describe and evaluate the application of new technology to detect bacterial and viral agents in high-grade prostate cancer tissues. the potential of targeted 16s rrna gene sequencing and total rna sequencing was evaluated in terms of its uti ... | 2017 | 28101126 |
| inhibition of propionibacterium acnes lipase activity by the antifungal agent ketoconazole. | the common skin disease acne vulgaris is caused by propionibacterium acnes. a lipase secreted by this microorganism metabolizes sebum and the resulting metabolites evoke inflammation in human skin. the antifungal drug ketoconazole inhibits p. acnes lipase activity. we previously showed that the drug also inhibits the growth of p. acnes. thus, ketoconazole may serve as an alternative treatment for acne vulgaris, which is important because the number of antibiotic-resistant p. acnes strains has be ... | 2017 | 28111792 |
| treatment effects of lysozyme-shelled microbubbles and ultrasound in inflammatory skin disease. | acne vulgaris is the most common skin disorder, and is caused by propionibacterium acnes (p. acnes) and can induce inflammation. antibiotic therapy often needs to be administered for long durations in acne therapy, which results in extensive antibiotic exposure. the present study investigated a new treatment model for evaluating the antibacterial effects of lysozyme (ly)-shelled microbubbles (mbs) and ultrasound (us)-mediated ly-shelled mbs cavitation against p. acnes both in vitro and in vivo, ... | 2017 | 28117399 |
| topical delivery of roxithromycin solid-state forms entrapped in vesicles. | recently, considerable interest developed in using newer/improved antibiotics for the treatment of acne vulgaris. during this study, different roxithromycin solid-state forms (i.e. crystalline and amorphous) were encapsulated into vesicle systems (niosomes, proniosomes, ufosomes and pro-ufosomes) for dermis targeted delivery. characterization of the vesicles was done with transmission electron microscopy, light microscopy, droplet size, droplet size distribution, ph, zeta-potential and entrapmen ... | 2017 | 28119103 |
| a multifactorial comparison of ternary combinations of essential oils in topical preparations to current antibiotic prescription therapies for the control of acne vulgaris-associated bacteria. | acne vulgaris, a chronic condition associated with overgrowth of propionibacterium acnes and staphylococcus epidermidis, is commonly treated with antibiotics. however, the emergence of antibiotic resistance has resulted in a need for alternative therapies. the aim of this study is to develop a topical preparation incorporating essential oils (eos) for use against acne-associated bacteria and assess its efficacy against prescription therapies dalacin t and stiemycin. antimicrobial screening of ro ... | 2017 | 28124400 |
| draft genome sequence of an erythromycin-resistant propionibacterium acnes isolate recovered from folliculitis of the scalp. | propionibacterium acnes is now well-known and recognized for its implication in the pathogenesis of acne vulgaris. here, we report the draft genome sequence of an erythromycin-resistant p. acnes strain isolated from a case of folliculitis of the scalp belonging to phylotype ia1 and sequence type 18 (st18). | 2017 | 28126936 |
| presence of biofilms on polyurethane-coated breast implants: preliminary results. | polyurethane-coated breast implants seem to be associated with lower medium- and long-term capsular contracture rates in comparison to textured or smooth implant surfaces. although the etiology of capsular contracture is uncertain, bacterial biofilms have been suggested to trigger chronic peri-implant inflammation, eventually leading to capsular contracture. it is unknown whether polyurethane-coated implants are less prone to biofilm colonization than other implant surfaces. we extracted data fr ... | 2016 | 28134606 |
| high throughput 16srrna gene sequencing reveals the correlation between propionibacterium acnes and sarcoidosis. | this study aims to use high throughput 16srrna gene sequencing to examine the bacterial profile of lymph node biopsy samples of patients with sarcoidosis and to further verify the association between propionibacterium acnes (p. acnes) and sarcoidosis. | 2017 | 28143482 |
| acne and rosacea. | acne, one of the most common skin diseases, affects approximately 85% of the adolescent population, and occurs most prominently at skin sites with a high density of sebaceous glands such as the face, back, and chest. although often considered a disease of teenagers, acne is occurring at an increasingly early age. rosacea is a chronic facial inflammatory dermatosis characterized by flushing (or transient facial erythema), persistent central facial erythema, inflammatory papules/pustules, and tela ... | 2017 | 28150107 |
| open-label, randomized, multicenter, phase iii study to evaluate the safety and efficacy of benzoyl peroxide gel in long-term use in patients with acne vulgaris: a secondary publication. | an open-label, randomized, multicenter study was conducted to evaluate the safety and efficacy of long-term use of 2.5% and 5% benzoyl peroxide (bpo) gels administrated once daily for 52 weeks to japanese patients with acne vulgaris. the efficacy of the study drugs was evaluated by counting inflammatory lesions and non-inflammatory lesions. safety was evaluated based on adverse events, local skin tolerability scores and laboratory test values. in total, 458 subjects were included in the efficacy ... | 2017 | 28150367 |
| is infection the possible initiator of disc disease? an insight from proteomic analysis. | proteomic and 16s rdna analysis of disc tissues obtained in vivo. | 2017 | 28168343 |
| measuring acne using coproporphyrin iii, protoporphyrin ix, and lesion-specific inflammation: an exploratory study. | propionibacterium acnes: (p. acnes) produce porphyrins; however, fluorescence measurement of porphyrins from ultraviolet-a (uva) images has failed to establish a correlation. acne clinical research and imaging has ignored the spectral excitation-emission characteristics and the exact pattern of the porphyrins synthesized by p. acnes. in this exploratory study, for the first time, the possible relationships of coproporphyrin iii (cpiii) and protoporphyrin ix (ppix) fluorescence as well as acne le ... | 2017 | 28180934 |
| propionibacterium acnes is developing gradual increase in resistance to oral tetracyclines. | propionibacterium acnes is an anaerobic bacterium that causes deep infection in organs and prosthetic joints, in addition to acne vulgaris. many tetracycline-resistant p. acnes strains have been isolated because oral tetracyclines are frequently used as an acne treatment against p. acnes. in this study, we found a novel tetracycline resistance mechanism in p. acnes. three doxycycline-resistant (mic: 16 µg ml-1) strains were isolated from 69 strains in acne patients in japan between 2010 and 2011 ... | 2017 | 28218057 |
| interaction of cutibacterium ( formerly propionibacterium) acnes with bone cells: a step toward understanding bone and joint infection development. | cutibacterium acnes (formerly propionibacterium acnes) is recognized as a pathogen in foreign-body infections (arthroplasty or spinal instrumentation). to date, the direct impact of c. acnes on bone cells has never been explored. the clade of 11 c. acnes clinical isolates was determined by mlst. human osteoblasts and osteoclasts were infected by live c. acnes. the whole genome sequence of six isolates of this collection was analyzed. cc36 c. acnes strains were significantly less internalized by ... | 2017 | 28218305 |
| late onset posttraumatic propionibacterium acnes endophthalmitis. | to report a case of late onset posttraumatic endophthalmitis secondary to propionibacterium acnes infection. | 2017 | 28221490 |
| primary intraocular lymphoma: another great masquerader. | to describe diverse and atypical presentations of the most common masquerader in neoplastic masquerade syndromes. | 2017 | 28221644 |
| specific infectious organisms associated with poor outcomes in treatment for hip periprosthetic infection. | periprosthetic hip infection treatment remains a significant challenge for orthopedics. some studies have suggested that methicillin resistance and gram-negative organism type are associated with increased treatment failure. the aim of this research is to determine if specific organisms were associated with poor outcomes in treatment for hip periprosthetic infection. | 2017 | 28222919 |
| clinicobacteriological study of acne vulgaris. | the aetiological relationship propionibacterium acnes in acne vulgaris has been suggested. a clinicobacteriological study in 45 patients suffering from acne vulgaris was conducted for the first time in indian patients. p acnes could be isolated from 18 (40.0%) and other propionibacterium species from 9 (20.0%) of the 45 patients studied. no correlation of culture positivity with the sex of the patient or duration and grade of the disease could be established, p acnes antibodies were, tested for ... | 2017 | 28223653 |
| propionibacterium acnes endophthalmitis in ahmed glaucoma valve. | to report a case of propionibacterium acnes endophthalmitis in a patient with an ahmed glaucoma valve. | 2017 | 28226111 |
| prospects of phage application in the treatment of acne caused by propionibacterium acnes. | propionibacterium acnes is associated with purulent skin infections, and it poses a global problem for both patients and doctors. acne vulgaris (acne) remains a problem due to its chronic character and difficulty of treatment, as well as its large impact on patients' quality of life. due to the chronic course of the disease, treatment is long lasting, and often ineffective. currently there are data regarding isolation of p. acnes phages, and there have been numerous studies on phage killing of p ... | 2017 | 28228751 |
| n-acetylcysteine inhibits growth, adhesion and biofilm formation of gram-positive skin pathogens. | n-acetylcysteine (nac) is a non-antibiotic drug with antimicrobial properties against biofilm phenotypes of gram-positive and gram-negative bacteria. our aim was to assess the effects of nac on the growth of gram-positive human skin and mucous membrane pathogens in the planktonic and biofilm phases. the minimum inhibitory concentrations (mics) of nac against enterococcus faecalis, corynebacterium ammoniagenes, mycobacterium smegmatis, propionibacterium acnes, staphylococcus aureus, s. epidermidi ... | 2017 | 28237766 |
| evaluation of dental adhesive systems incorporating an antibacterial monomer eugenyl methacrylate (egma) for endodontic restorations. | the purpose of this study was to incorporate egma, an antibacterial monomer into two commercial dental adhesive systems for their application in endodontic restoration with the aim to disinfect the root canal space before curing and to inhibit bacterial growth on their surfaces after being cured. | 2017 | 28245928 |
| the evaluation of cultivable microbiota profile in patients with secondary endodontic infection before and after photo-activated disinfection. | secondary/persistent endodontic infection can be the outcome of failure of endodontic treatment. photo-activated disinfection (pad) can be a useful adjunct to mechanical and antimicrobial agents in eliminating endopathogenic microorganisms. in this study, we evaluated the effect of pad on diversity and count of microbiota related to secondary/persistent endodontic infections. | 2017 | 28249746 |
| propionibacterium acnes infection of a metacarpophalangeal joint arthroplasty. | neglected and underestimated in the past, propionibacterium acnes is currently the most prevalent organism associated with deep prosthetic infections around the shoulder. surprisingly, it has never been reported as a cause of infection in the hand. here we report a case of a late presentation of a p. acnes infection in a metacarpophalangeal joint replacement, resulting in chronic low-grade pain with movement. the patient underwent a 2-stage revision, with initial removal of the prosthesis. posit ... | 2017 | 28259563 |
| propionibacterium acnes as a possible pathogen of granuloma in patients with ocular sarcoidosis. | to detect propionibacterium acnes from intraocular granuloma in patients with ocular sarcoidosis. | 2017 | 28270483 |
| understanding the role of propionibacterium acnes in acne vulgaris: the critical importance of skin sampling methodologies. | acne vulgaris is a chronic inflammatory skin condition classified by the global burden of disease study as the eighth most prevalent disease worldwide. the pathophysiology of the condition has been extensively studied, with an increase in sebum production, abnormal keratinization of the pilosebaceous follicle, and an inflammatory immune response all implicated in its etiology. one of the most disputed points, however, is the role of the gram-positive anaerobic bacterium propionibacterium acnes i ... | 2017 | 28274348 |
| propionibacterium acnes and antimicrobial resistance in acne. | the human commensal bacterium propionibacterium acnes (p. acnes) resides in the pilosebaceous duct of the skin. it has been long implicated in the pathogenesis of acne, although its exact role in the development of inflammatory acne lesions and in the formation of the microcomedo in the early stages of acne remains controversial. the worldwide prevalence of antibiotic-resistant p. acnes is increasing, with rates varying in different parts of the world. the reason for the difference in the antibi ... | 2017 | 28274353 |
| topical treatments for acne. | topical drugs have been used successfully to treat acne for decades. this review discusses the use, efficacy, and safety of options available via prescription. topical antibiotics, dapsone, benzyl peroxide, azelaic acid, and topical retinoids are included. topical antibiotics should not be used as monotherapy but rather be combined with other agents to avoid resistant propionibacterium acnes strains. benzoyl peroxide is effective in preventing bacteria resistance. topical retinoids address prima ... | 2017 | 28274355 |
| performance of two blood culture systems to detect anaerobic bacteria. is there any difference? | we studied the performance characteristics of two blood culture (bc) bottles/systems, (i) bact/alert-fn plus/3d (biomérieux, marcy l'étoile, france) and (ii) bactec-lytic/9000 (becton dickinson, sparks, usa) for detection of growth and time-to-positivity (ttp) against a balanced and diverse collection of anaerobic bacterial strains (n = 48) that included reference strains (n = 19) and clinical isolates (n = 29) of 32 species (15 gram-negative and 17 gram-positive). standard suspension of bacteri ... | 2017 | 28279857 |
| establishment of multiplex solid-phase strip pcr test for detection of 24 ocular infectious disease pathogens. | to establish and evaluate a new multiplex solid-phase strip polymerase chain reaction (strip pcr) for concurrent detection of common ocular infectious disease pathogens. | 2017 | 28282487 |
| periprosthetic joint infection by propionibacterium acnes: clinical differences between monomicrobial versus polymicrobial infection. | to compare a series of monomicrobial propionibacterium acnes (p. acnes) knee and hip periprosthetic joint infection (pji) cases with cases of polymicrobial pji which included p. acnes. we hypothesized that the presence of a polymicrobial p. acnes infection would lead to worse outcomes than those in cases of monomicrobial p. acnes pji. | 2017 | 28285096 |
| diverse bacterial communities exist on canine skin and are impacted by cohabitation and time. | it has previously been shown that domestic dogs and their household owners share bacterial populations, and that sharing of bacteria between humans is facilitated through the presence of dogs in the household. however, less is known regarding the bacterial communities of dogs, how these communities vary by location and over time, and how cohabitation of dogs themselves influences their bacterial community. furthermore, the effects of factors such as breed, hair coat length, sex, shedding, and ag ... | 2017 | 28289569 |
| valve dehiscence after bentall procedure: the detrimental traits of propionibacterium. | the present case exemplified the detrimental traits of prosthetic valve endocarditis caused by propionibacterium acnes. as a baby, the patient had a congenital cardiac defect with truncus arteriosus type i with interrupted aortic arch and open ductus botalli, and had undergone several operations. however, at 18 months after a bentall procedure performed 29 years later he presented with major prosthetic dehiscence due to endocarditis. the patient underwent a high-risk reoperation for a re-do bent ... | 2016 | 28290176 |
| the influence of direct inoculation of propionibacterium acnes on modic changes in the spine: evidence from a rabbit model. | modic changes (inflammatory-like changes visible on magnetic resonance imaging [mri] scans of a vertebral end plate) are common and are associated with low back pain, but their origin is unclear. to our knowledge, there have been no previous in vivo animal models of modic changes. we hypothesized that modic changes may be related to propionibacterium acnes. | 2017 | 28291179 |
| propionibacterium acnes phylotypes and acne severity: an observational prospective study. | although a number of facts on the physiopathological mechanisms of acne are now well established, it is still unclear what triggers the severity of this inflammatory disease of the sebaceous follicle. thus, could the severity of the acne be somehow linked to different strains of its main bacterium, propionibacterium acnes? we know that there are several types of p. acnes, and a study (1) has recently shown that different strains of p. acnes could up-regulate or down-regulate in vitro inflammator ... | 2017 | 28295699 |
| treatment of leishmania (leishmania) amazonensis-infected mice with a combination of a palladacycle complex and heat-killed propionibacterium acnes triggers protective cellular immune responses. | palladacycle complex dppe 1.2 was previously reported to inhibit the in vitro and in vivo infection by leishmania (leishmania) amazonensis. the aim of the present study was to compare the effect of dppe 1.2, in association with heat-killed propionibacterium acnes, on l. (l.) amazonensis infection in two mouse strains, balb/c and c57bl/6, and to evaluate the immune responses of the treated animals. foot lesions of l. (l.) amazonensis-infected mice were injected with dppe 1.2 alone, or associated ... | 2017 | 28321209 |
| deciphering the effect of novel bacterial exopolysaccharide-based nanoparticle cream against propionibacterium acnes. | acne vulgaris (acne) is a chronic inflammatory disease prevalent among adolescents and adults, with significant psychological effects. the aetiology of acne is multifactorial. several pathophysiological associations have been identified in which propionibacterium acnes plays a major role. this bacteria primarily affects areas containing oil glands including the face, back and trunk, where it causes the formation of seborrhoea and inflammatory lesions. the treatment methods currently in place hav ... | 2016 | 28330105 |
| p. acnes-driven disease pathology: current knowledge and future directions. | this review discusses the biology and behavior of propionibacterium acnes (p. acnes), a dominant bacterium species of the skin biogeography thought to be associated with transmission, recurrence and severity of disease. more specifically, we discuss the ability of p. acnes to invade and persist in epithelial cells and circulating macrophages to subsequently induce bouts of sarcoidosis, low-grade inflammation and metastatic cell growth in the prostate gland. finally, we discuss the possibility of ... | 2017 | 28352613 |
| a metabolic engineering strategy for producing conjugated linoleic acids using the oleaginous yeast yarrowia lipolytica. | conjugated linoleic acids (clas) have been found to have beneficial effects on human health when used as dietary supplements. however, their availability is limited because pure, chemistry-based production is expensive, and biology-based fermentation methods can only create small quantities. in an effort to enhance microbial production of clas, four genetically modified strains of the oleaginous yeast yarrowia lipolytica were generated. these mutants presented various genetic modifications, incl ... | 2017 | 28357546 |
| low-grade infections in nonarthroplasty shoulder surgery. | recent studies have identified the diagnostic challenge of low-grade infections after shoulder arthroplasty surgery. infections after nonarthroplasty procedures have not been reported. this study assessed patient-related risk factors, outcomes, and clinical presentation of low-grade infection after open and arthroscopic nonarthroplasty shoulder surgery. | 2017 | 28359693 |
| propionibacterium acnes biofilm is present in intervertebral discs of patients undergoing microdiscectomy. | in previous studies, propionibacterium acnes was cultured from intervertebral disc tissue of ~25% of patients undergoing microdiscectomy, suggesting a possible link between chronic bacterial infection and disc degeneration. however, given the prominence of p. acnes as a skin commensal, such analyses often struggled to exclude the alternate possibility that these organisms represent perioperative microbiologic contamination. this investigation seeks to validate p. acnes prevalence in resected dis ... | 2017 | 28369127 |
| cell type-specific regulatory effects of glucocorticoids on cutaneous tlr2 expression and signalling. | glucocorticoids (gcs) induce toll-like receptor (tlr) 2 expression and synergistically upregulate tlr2 with pro-inflammatory cytokines or bacteria. these paradoxical effects have drawn attention to the inflammatory initiating or promoting effects of gcs, as gc treatment can provoke inflammatory skin diseases. here, we aimed to investigate the regulatory effects of gcs in human skin cells of different epidermal and dermal layers. we found that dex induced tlr2 expression mainly in undifferentiate ... | 2017 | 28377308 |
| acute hemiparesis in a healthy elderly woman: where and what is the lesion? | hemiparesis may be the result of lesions in the contralateral pyramidal tract in the brain or, less frequently, in the ipsilateral pyramidal tract in the upper cervical spinal cord. however, although rare, multiple lesions that simultaneously occur in both of these regions may be the cause of acute hemiparesis, and the clinical symptoms can often be misdiagnosed as a stroke. in addition, the correct diagnosis of these multiple central nervous system (cns) lesions is very challenging if they are ... | 2017 | 28377743 |
| filthy lucre: a metagenomic pilot study of microbes found on circulating currency in new york city. | paper currency by its very nature is frequently transferred from one person to another and represents an important medium for human contact with-and potential exchange of-microbes. in this pilot study, we swabbed circulating $1 bills obtained from a new york city bank in february (winter) and june (summer) 2013 and used shotgun metagenomic sequencing to profile the communities found on their surface. using basic culture conditions, we also tested whether viable microbes could be recovered from b ... | 2017 | 28384336 |
| propionibacterium acnes phylogenetic type iii is associated with progressive macular hypomelanosis. | progressive macular hypomelanosis (pmh) is a skin disorder that is characterized by hypopigmented macules and usually seen in young adults. the skin microbiota, in particular the bacterium propionibacterium acnes, is suggested to play a role. here, we compared the p. acnes population of 24 pmh lesions from eight patients with corresponding nonlesional skin of the patients and matching control samples from eight healthy individuals using an unbiased, culture-independent next-generation sequencing ... | 2017 | 28386469 |
| bactericidal activity and post-antibiotic effect of ozenoxacin against propionibacterium acnes. | ozenoxacin, a novel non-fluorinated topical quinolone, is used for the treatment of acne vulgaris in japan. we investigated bactericidal activity and post-antibiotic effect (pae) of ozenoxacin against propionibacterium acnes, a major causative bacterium of acne vulgaris. the minimum inhibitory concentrations (mics) of ozenoxacin against 3 levofloxacin-susceptible strains (mic of levofloxacin; ≤4 μg/ml) and 3 levofloxacin-resistant strains (mic of levofloxacin; ≥8 μg/ml) ranged from 0.03 to 0.06 ... | 2017 | 28389164 |
| endocarditis caused by anaerobic bacteria. | infective endocarditis (ie) caused by anaerobic bacteria is a rare and poorly characterized disease. most data reported in the literature are from case reports [1-3]. therefore, we assessed the situation of anaerobic ie (aie) in spain using the database of the spanish collaboration on endocarditis (games). | 2017 | 28389412 |
| epidemiology and antibiotic resistance of late prosthetic knee and hip infections. | prosthetic joint infections (pji) are still a major complication of hip and knee arthroplasties. identification of the causative pathogens and knowledge of their antibiotic susceptibilities are essential for the management of these infections. the main purpose of the study was to identify and compare the causative bacteria of prosthetic knee and hip joint infections in a reference italian orthopedic center and to characterize antibiotic resistance profiles of bacteria involved. | 2017 | 28390886 |
| antibacterial activity of ethanolic extract of cinnamon bark, honey, and their combination effects against acne-causing bacteria. | propionibacterium acnes and staphylococcus epidermidis are the major skin bacteria that cause the formation of acne. the present study was conducted to investigate antibacterial activity of ethanolic extract of cinnamon bark, honey, and their combination against acne bacteria. the antibacterial activity of extract of cinnamon bark and honey were investigated against p. acnes and s. epidermidis using disc diffusion. minimum inhibitory concentrations (mics) and minimum bactericidal concentrations ... | 2017 | 28398231 |
| propionibacterium acnes incubation in the discs can result in time-dependent modic changes: a long term rabbit model. | a case control study of animal model of modic changes (mcs) on rabbits. | 2017 | 28399545 |
| histological identification of propionibacterium acnes in nonpyogenic degenerated intervertebral discs. | purpose. low-virulence anaerobic bacteria, especially the propionibacterium acnes (p. acnes), have been thought to be a new pathogeny for a series of disc diseases. however, until now, there has been no histological evidence to confirm this link. the purpose of this study was to confirm the presence of p. acnes in nonpyogenic intervertebral discs via histological observation. method. degenerated intervertebral discs were harvested from 76 patients with low back pain and/or sciatica but without a ... | 2017 | 28401158 |
| the microbiome of the prostate tumor microenvironment. | the advent of molecular-based methods of identification and characterization of complex microbial populations has led to a new era of microbial discovery. a detailed and comprehensive analysis of the microbial ecosystem of the pathologic and healthy prostate tissues has not been yet reported. | 2017 | 28434677 |
| a comparative study of cutibacterium (propionibacterium) acnes clones from acne patients and healthy controls. | cutibacterium (propionibacterium) acnes is assumed to play an important role in the pathogenesis of acne. | 2017 | 28434779 |
| comparative antimicrobial efficacy of selected root canal irrigants on commonly isolated microorganisms in endodontic infection. | this study aims to evaluate and compare the antimicrobial efficacy of three selected root canal irrigants (biopure mtad, metronidazole, aztreonam) against microbes commonly isolated from polymicrobial microbiota of root canal infection. | 2017 | 28435359 |
| tropism and virulence of cutibacterium (formerly propionibacterium) acnes involved in implant-associated infection. | the recognition of the pathogenicity of cutibacterium acnes in implant-associated infection is not always obvious. in this paper, we aimed to distinguish pathogenic and non-pathogenic c. acnes isolates. to reach this goal, we investigated the clonal complex (cc) of a large collection of c. acnes clinical isolates through multi-locus sequence typing (mlst), we established a caenorhabditis elegans model to assess c. acnes virulence and we investigated the presence of virulence factors in our colle ... | 2017 | 28454760 |
| reduction in bacterial load using hypochlorous acid hygiene solution on ocular skin. | to examine the magnitude of bacterial load reduction on the surface of the periocular skin 20 minutes after application of a saline hygiene solution containing 0.01% pure hypochlorous acid (hocl). | 2017 | 28458509 |
| identification and characterization of multifunctional cationic and amphipathic peptides from soybean proteins. | in this study, we identified and chemically synthesized three cationic and amphipathic peptides (glycinin-17, bcas-16, and bcbs-11) from soybean proteins. these peptides had high isoelectric points, high positive net charges, and included multiple hydrophobic amino acids. subsequently, we identified multiple functions of these peptides, including antimicrobial, lipopolysaccharide-neutralizing, and angiogenic activities, and examined their cytotoxic activities against mammalian red blood cells. g ... | 2017 | 28459130 |
| [effect of silver nanoparticles on anaerobic bacteria]. | the aim was to evaluate the antibacterial effect of silver nanoparticles on anaerobic bacteria. | 2017 | 28467592 |
| green synthesis of conjugated linoleic acids from plant oils using a novel synergistic catalytic system. | a novel and efficient method has been developed for converting plant oil into a specific conjugated linoleic acid (cla) using a synergistic biocatalytic system based on immobilized propionibacterium acnes isomerase (pai) and rhizopus oryzae lipase (rol). pai exhibited the greatest catalytic activity when immobilized on d301r anion-exchange resin under optimal conditions (pai dosage of 12 410 u of pai/g of d301r, glutaraldehyde concentration of 0.4%, and reaction conditions of ph 7.0, 25 °c, and ... | 2017 | 28470063 |
| benzoyl peroxide and clindamycin topical skin preparation decreases propionibacterium acnes colonization in shoulder arthroscopy. | propionibacterium acnes is a gram-positive anaerobe that can lead to devastating postoperative shoulder infections. the objective of this study was to investigate whether a benzoyl peroxide and clindamycin preoperative skin preparation reduces the incidence of p. acnes colonization during shoulder arthroscopy. | 2017 | 28479255 |
| delayed manifestation of shunt nephritis: a case report and review of the literature. | we present an unusual case of shunt nephritis in a 39-year-old male who presented 21 years after placement of a ventriculoperitoneal (vp) shunt. he complained of fevers, headaches, dizziness, and urticarial plaques on arms, trunks, and legs and was found to have anemia, low complement levels, elevated serum creatinine, proteinuria, and new onset microhematuria. blood and urine cultures were negative. renal biopsy showed features of acute tubulointerstitial nephritis attributed to vancomycin use. ... | 2017 | 28487790 |
| post-operative spondylodiscitis due to propionibacterium acnes: a case report. | post-operative spondylodiscitis due to propionibacterium acnes is rare, with only a few cases reported in the literature. in this article, we report the case of a 76-year-old patient who suffered from spondylodiscitis t12-l1 discovered after 1 month of pain and fever. antibiotic treatment was administered for 6 weeks without revision surgery. diagnosis remains incomplete, and preventive therapy against this infection is not well known. there is no link between immunosuppression and this infectio ... | 2017 | 28495228 |
| sapho, autophagy, il-1, foxo1, and propionibacterium (cutibacterium) acnes. | overt infection by propionibacterium acnes is lacking in many sapho syndromes, and antibiotics have only a transient and incomplete effect, either in sapho syndrome or acne. as several auto-inflammatory bone disorders sharing overproduction of il-1β can mimic sapho, this syndrome could partly depend on genetically encoded overproduction of il-1β. however, cyclic intracellular infections, mostly by p. acnes, can contribute to the enhanced il-1β release by some skin cells, and probably by bone cel ... | 2017 | 28499891 |
| periprosthetic shoulder infection: an overview. | periprosthetic shoulder infection (psi) is rare but potentially devastating. the rate of psi is increased in cases of revision procedures, reverse shoulder implants and co-morbidities. one specific type of psi is the occurrence of low-grade infections caused by non-suppurative bacteria such as propionibacterium acnes or staphylococcus epidemermidis.success of treatment depends on micro-organism identification, appropriate surgical procedures and antibiotic administration efficiency. post-operati ... | 2017 | 28507783 |
| high incidence of periprosthetic joint infection with propionibacterium acnes after the use of a stemless shoulder prosthesis with metaphyseal screw fixation - a retrospective cohort study of 241 patients propionibacter infections after eclipse tsa. | a stemless shoulder prosthesis with humeral metaphyseal screw fixation was introduced in order to save bone-stock and to facilitate reconstruction of biomechanics (eclipse®). the aim of this study was to analyze whether the risk of infection is different with this implant compared to conventional shoulder prosthesis. | 2017 | 28526023 |
| can 16s rrna pcr be the solution for a rapid detection of propionibacterium acnes in surgical shoulder or spine samples? comments on "a rapid method for detecting propionibacterium acnes in surgical biopsy specimens from the shoulder". | 2017 | 28526424 | |
| response to: can 16s rrna pcr be the solution for a rapid detection of propionibacterium acnes in surgical shoulder or spine samples? comments on "a rapid method for detecting propionibacterium acnes in surgical biopsy specimens from the shoulder". | 2017 | 28526425 | |
| the follicular skin microbiome in patients with hidradenitis suppurativa and healthy controls. | although the pathogenesis of hidradenitis suppurativa (hs) remains enigmatic, several factors point to potential involvement of the cutaneous microbiome. insight into the cutaneous microbiome in hs using next-generation sequencing may provide novel data on the microbiological diversity of the skin. | 2017 | 28538949 |
| commercial essential oils as potential antimicrobials to treat skin diseases. | essential oils are one of the most notorious natural products used for medical purposes. combined with their popular use in dermatology, their availability, and the development of antimicrobial resistance, commercial essential oils are often an option for therapy. at least 90 essential oils can be identified as being recommended for dermatological use, with at least 1500 combinations. this review explores the fundamental knowledge available on the antimicrobial properties against pathogens respo ... | 2017 | 28546822 |
| effect of propionibacterium acnes (pa) injection on intervertebral disc degeneration in a rat model: does it mimic modic changes? | multiple reports of bacterial isolates in human disc tissue have suggested a role of low-grade infection on intervertebral disc degeneration and modic changes (mc) generation. animal models have been extensively used to study idd; however, until recently, no consideration had been given to eventual infectious processes. to reproduce the phenomena by inoculating an infecting agent would support the infectious hypothesis. therefore, we studied the effect of propionibacterium acnes (pa) inoculation ... | 2017 | 28552835 |
| endocrine disorders and hormonal therapy for adolescent acne. | acne vulgaris is a global disease with increasing prevalence in adolescents. it has a profound impact on their quality of life, especially when endocrine disorders are also involved. recent concerns regarding antibiotic stewardship, failures with antibiotic usage, and the development of antibiotic-resistant propionibacterium acnes have led clinicians to consider other therapeutic options for acne treatment. the present review explores hormonal therapies for the treatment of acne vulgaris. | 2017 | 28562419 |
| detection of the relatively slow-growing propionibacterium acnes in seven matrices of blood components and advanced therapeutical medicinal products. | relatively slow-growing bacteria like propionibacterium acnes represent a challenge for quality control investigations in sterility release testing of blood components and advanced therapeutic medicinal products (atmps). | 2017 | 28571932 |
| an unusual pathogen causing native valve endocarditis. | we present the case of a gentleman who was being evaluated for restrictive lung disease and was incidentally found to have mitral valve stenosis on an hrct. during the surgical procedure for valve replacement, he was found to have an abscess around the native mitral valve which was drained. pus from the abscess as well as the valve tissue grew propionibacterium acnes after holding the cultures long. the patient was treated with iv ceftriaxone with good response to therapy. while propionibacteriu ... | 2017 | 28586598 |
| genetic architecture of acne vulgaris. | acne vulgaris is a ubiquitary skin disease characterized by chronic inflammation of the pilosebaceous unit resulting from bacterial colonization of hair follicles by propionibacterium acnes, androgen-induced increased sebum production, altered keratinization and inflammation. | 2017 | 28593717 |
| erratum to: high incidence of periprosthetic joint infection with propionibacterium acnes after the use of a stemless shoulder prosthesis with metaphyseal screw fixation - a retrospective cohort study of 241 patients propionibacter infections after eclipse tsa. | 2017 | 28595609 | |
| in vitro emergence of fluoroquinolone resistance in cutibacterium (formerly propionibacterium) acnes and molecular characterization of mutations in the gyra gene. | in vitro occurrence of levofloxacin (lvx) resistance in c. acnes and characterization of its molecular background were investigated. the mutation frequency was determined by inoculation of 10(8) cfu of c. acnes atcc 11827 (lvx mic = 0.25 mg/l) on lvx-containing agar plates. the progressive emergence of resistance was studied by a second exposure to increasing lvx concentrations. for mutants, the qrdr regions including the gyra and parc genes were sequenced and compared to both c. acnes atcc 1182 ... | 2017 | 28602804 |
| a polycation antimicrobial peptide mimic without resistance buildup against propionibacterium acnes. | a preliminary study is reported for a polycation antimicrobial peptide (amp) mimic against propionibacterium acnes, which is associated with acne vulgaris, a common skin condition. antibiotics are commonly used against p. acnes but buildup of resistance is well-known. worse, antibiotic regimens build up resistance for more sensitive bacteria such as staphylococcus epidermidis. the polycation amp mimic c12-50, 1, is chosen for the present study as it has been previously shown to have high antimic ... | 2017 | 28605136 |
| a comparison of culture and pcr methods for identifying propionibacterium acnes in lesions isolated from patients with acne. | one of the factors that affect the occurrence of acne is the presence of propionibacterium acnes. the present study was conducted to compare the culture and polymerase chain reaction (pcr) methods for identifying p. acnes in lesions isolated from patients with acne. | 2017 | 28618752 |
| propionibacterium acnes is an unusual cause of acute scrotal abscess in a preterm infant. | acute scrotal abscess is an extremely rare condition in neonates and may mimic testicular torsion. most of these abscesses have reportedly been due to staphylococcus and salmonella spp. infections. we herein report a unilateral acute scrotal abscess in a preterm infant born at 26 weeks in whom propionibacterium acnes was isolated from the collected scrotal fluid culture. to our knowledge, this is the first case report implicating p. acnes as a causative agent of neonatal scrotal abscess. based o ... | 2017 | 28620560 |
| b cell cross-epitope of propionibacterium acnes and actinobacillus pleuropneumonia selected by phage display library can efficiently protect from actinobacillus pleuropneumonia infection. | contagious porcine pleuropneumonia (cpp), caused by actinobacillus pleuropneumoniae (app), is a highly transmissible and fatal respiratory illness that causes tremendous economic losses for the pig breeding industry worldwide. propionibacterium acnes (pa) has a strong cross-reaction with anti-app1 and anti-app5 serum and can efficiently prevent app infection, which was fortuitously found in researching the differential gene between the different app serotypes. there seems to be some natural cros ... | 2017 | 28622855 |
| temporomandibular prosthetic joint infections associated with propionibacterium acnes: a case series, and a review of the literature. | the orthopedic literature has shown an increasing incidence of prosthetic joint infections (pjis) associated with propionibacterium acnes (p acnes). these infections present serious diagnostic and management challenges to the treating surgeons. in this review, the authors report on cases of p acnes-related temporomandibular joint (tmj) pjis that have been diagnosed and treated at their institution. | 2017 | 28623686 |
| antimicrobial susceptibility and phylogenetic analysis of propionibacterium acnes isolated from acne patients in japan between 2013 and 2015. | the prevalence of antimicrobial-resistant propionibacterium acnes strains isolated from acne patients has been increasing in japan. here, to estimate the current resistance rate, we tested antimicrobial susceptibility among p. acnes from acne patients having visited a specialized dermatology clinic between 2013 and 2015. rates of resistance to macrolides and clindamycin were 44.3 (31/70) and 38.6% (27/70), respectively. erm(x), which confers high-level clindamycin resistance (minimum inhibitory ... | 2017 | 28623856 |
| accumulation of porphyrins in propionibacterium acnes by 5-aminolevulinic acid and its esters. | we have investigated the accumulation of porphyrins in propionibacterium acnes (p.acnes) by 5-aminolevulinic acid hydrochloride (ala) and its esters, ala methyl ester hydrochloride (mala), ala octyl ester hydrochloride (oala), and ala benzyl ester hydrochloride (bala). from the fluorescence spectra of porphyrins accumulated in p.acnes, the order of porphyrin accumulation is as follows: ala≫mala≈bala>oala (≈0). moreover, the pdt efficacy is reduced in the order of ala>mala≈bala>oala (≈without add ... | 2017 | 28624551 |
| mikania glomerata sprengel extract and its major compound ent-kaurenoic acid display activity against bacteria present in endodontic infections. | the search for new, effective and safe antimicrobial compounds from plant sources has continued to play an important role in the maintenance of human health since ancient times. such compounds can be used to help to eradicate microorganisms from the root canal system, preventing/healing periapical diseases. mikania glomerata (spreng.), commonly known as "guaco," is a native climbing plant from brazil that displays a wide range of pharmacological properties. many of its activities have been attri ... | 2017 | 28627377 |
| tumour necrosis factor (tnf) inhibitor-induced isolated pleural granulomas: a rare adverse effect. | a 53-year-old man with a history of crohn's disease on infliximab, presented with several weeks of cough and dyspnoea. he had a right-sided pleural effusion, found to be exudative with lymphocytic predominance. he underwent right-sided video-assisted thoracic surgery (vats) with biopsies and pleurodesis. histopathology showed pleural-based non-caseating granulomas with unremarkable lung parenchyma. cultures were only positive for propionibacterium acnes 8 months later, he was found to have a lef ... | 2017 | 28630242 |
| antibiotic resistance in acne treatment. | what is the evidence for antibiotic resistance in acne, and how does resistance affect treatment? | 2017 | 28636689 |
| isotretinoin and lymecycline treatments modify the skin microbiota in acne. | oral retinoids and tetracyclines have a major role in acne treatment. here, we report for the first time the effect of isotretinoin and lymecycline therapy on the skin microbiota in cheek, back and armpit swab samples of acne vulgaris patients using 16s ribosomal rna (16s rrna) gene amplicon sequencing. propionibacterium acnes was the most common in sebaceous areas of healthy and untreated acne skin and more abundant in back than cheek samples. five taxa, including a streptococcus taxon, differe ... | 2017 | 28636791 |
| propionibacterium acnes pleural empyema following medical thoracoscopy. | propionibacterium acnes (p. acnes) is a gram-positive anaerobic rod and a common skin commensal that colonizes sebaceous glands. it has infrequently been associated with invasive opportunistic infections and can cause implant-associated infections through a biofilm mode of growth. medical thoracoscopy is a common procedure for diagnosis and treatment of exudative pleural effusions; empyema is a recognized complication. we present a rare case of p. acnes pleural empyema 3 weeks following medical ... | 2017 | 28638619 |
| sebum lipids influence macrophage polarization and activation. | as lipids are known to regulate macrophage functions it is reasonable to suppose that a sebocyte - macrophage axis mediated by sebum lipids may exist. | 2017 | 28646583 |
| olumacostat glasaretil, a promising topical sebum-suppressing agent that affects all major pathogenic factors of acne vulgaris. | hunt et al. show that olumacostat glasaretil, an inhibitor of acetyl coenzyme a carboxylase, reduces saturated and monounsaturated fatty acyl chains in sebaceous lipids. topical olumacostat glasaretil application decreases hamster ear sebaceous gland size and shows efficacy in treating patients with acne vulgaris. olumacostat glasaretil-mediated sebum suppression may reduce propionibacterium acnes growth and biofilm formation, comedogenesis, and inflammation. | 2017 | 28647025 |
| difficult-to-detect low-grade infections responsible for poor outcomes in total knee arthroplasty. | in this article, we present the case of a patient with a stiff, painful knee after total knee arthroplasty, and with erythrocyte sedimentation rate, c-reactive protein level, and synovial fluid analysis within normal limits. open biopsy for cultures showed propionibacterium acnes prosthetic joint infection, which was successfully treated with 2-stage revision and intravenous antibiotics. | 2017 | 28666043 |
| akne. | akne ist eine chronische erkrankung mit hoher prävalenz unter jugendlichen. pathogenetische hauptfaktoren (und ihre klinischen korrelate) sind gesteigerte talgproduktion (seborrhoe), follikuläre hyperkeratose (komedonen) und perifollikuläre entzündungsvorgänge (papulopusteln). die krankheit wird von endogenen (androgene, igf-1, neuroendokrine faktoren) und exogenen (propionibacterium acnes, diät, mechanische irritation, inhaltsstoffe medizinischer oder kosmetischer externa) einflüssen moduliert. ... | 2017 | 28677193 |
| acne. | acne is a chronic disease with a high prevalence among adolescents. key pathogenetic factors (and their clinical correlates) are increased sebum production (seborrhea), follicular hyperkeratosis (comedones), and perifollicular inflammation (papules and pustules). the disease is modulated by a variety of endogenous (androgens, igf-1, neuroendocrine factors) and exogenous (propionibacterium acnes, diet, friction, ingredients of medical or cosmetic topical products) triggers. acne is associated wit ... | 2017 | 28677199 |
| combination of benzoyl peroxide 5% gel with liquid cleanser and moisturizer spf 30 in acne treatment results in high levels of subject satisfaction, good adherence and favorable tolerability. | skin care products (cleansers and moisturizers) to complement benzoyl peroxide (bpo) in the treatment of acne may improve treatment tolerability and adherence. | 2017 | 28678647 |
| a case of bilateral hilar and mediastinal lymphadenopathy developing during treatment for mycobacterium avium complex. | we report a rare case of an immunocompetent patient with mycobacterium avium complex (mac) disease in which bilateral hilar lymphadenopathy developed during anti-mac treatment. this case indicates that propionibacterium acnes would be present and might be a cause of sarcoidosis even in patients with mac. | 2017 | 28680616 |
| immunohistochemical identification of propionibacterium acnes in granuloma and inflammatory cells of myocardial tissues obtained from cardiac sarcoidosis patients. | although rare, cardiac sarcoidosis (cs) is potentially fatal. early diagnosis and intervention are essential, but histopathologic diagnosis is limited. we aimed to detect propionibacterium acnes, a commonly implicated etiologic agent of sarcoidosis, in myocardial tissues obtained from cs patients. | 2017 | 28686683 |
| propionibacterium acnes host inflammatory response during periprosthetic infection is joint specific. | propionibacterium acnes (p. acnes) has become increasingly recognized as a cause of periprosthetic joint infection (pji). | 2017 | 28690466 |
| association between post-craniotomy propionibacterium acnes infection and dural implants: a case-control study. | in 2011, 15 deep-seated propionibacterium acnes infections were identified in patients following craniotomies in a hospital in the uk. | 2017 | 28694086 |
| combined photodynamic and antibiotic therapy for skin disorder via lipase-sensitive liposomes with enhanced antimicrobial performance. | a lipase-sensitive singlet oxygen-producible and erythromycin-loaded liposome (lsspl) was developed for combination antibacterial therapy for skin disorder. the lsspl was synthesized by coating pullulan-pheophorbide a (pu-pheo a) conjugates onto erythromycin-loaded liposomes composed of 1,2-dipalmitoyl-sn-phosphatidylcholine (dppc) and cholesterol. lipase activity was chosen as the environmental-stimulus for the controlled release of erythromycin and pheo a from lsspl because skin inflammation-i ... | 2017 | 28697465 |
| [diagnosis of periprosthetic joint infection of shoulder arthroplasties]. | periprosthetic joint infection of shoulder arthroplasties is one of the most frequent reasons for pain and revision surgery of shoulder arthroplasties. propionibacterium acnes is one of the commonest microorganisms causing periprosthetic joint infection in shoulder arthroplasties. it is difficult to detect this slow growing microorganism. this paper gives an overview of the different diagnostic methods. a combination of unspecific and specific tests (detection of microorganism and sensitivity to ... | 2017 | 28701012 |