Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| isolation and structure of bacterial sex pheromone, cpd1. | the streptococcus faecalis sex pheromone cpd1, which induces a mating response in cells harboring the conjugative plasmid ppd1, has been isolated and its structure determined. it was found to have a molecular weight of 912, and its amino acid sequence was h-phe-leu-val-met-phe-leu-ser-gly-oh. a synthetic octapeptide showed the same biological activity and chromatographic behavior as the isolated cpd1. pheromone activity was detectable at a concentration of approximately 4 x 10(-11)m. | 1984 | 6436978 |
| the effects of heparin on the adherence of five species of urinary tract pathogens to urinary bladder mucosa. | previous studies performed in our laboratory have indicated that the primary antibacterial defense mechanism of the rabbit urinary bladder is the antiadsorptive action of the surface mucopolysaccharide. removal of this layer with an acid rinse increases bacterial adherence up to 100 fold. exogenous mucopolysaccharide (heparin) has been shown to restore escherichia coli adherence to control levels. to determine whether this antiadherence action of heparin is species specific, we compared the adhe ... | 1984 | 6437032 |
| drug resistance in streptococcus faecalis, streptococcus faecium and staphylococcus epidermidis isolated from laboratory animals. | a total of 1,278 strains of streptococcus faecalis, 688 of str. faecium and 796 of staphylococcus epidermidis were collected from laboratory animals of 20 colonies in 1980, and tested for their resistance to 20 drugs. thirteen percent of str. faecalis, 12% of str. faecium and 25% of staph. epidermidis were drug resistant. multiple drug resistant organisms were frequently detected in laboratory animal colonies where antibiotic treatment had been undertaken. tc-resistant streptococci and em-resist ... | 1984 | 6437850 |
| isolation and structure of the bacterial sex pheromone, cad1, that induces plasmid transfer in streptococcus faecalis. | the streptococcus faecalis sex pheromone cad1, which is involved in the conjugative transfer of the hemolysin plasmid pad1, has been isolated and its structure determined. its mr is 818 and its amino acid sequence is h-leu-phe-ser-leu-val-leu-ala-gly-oh. a replicate of the pheromone synthesized by the liquid-phase method showed the same biological activity and chromatographic behavior as the isolated cad1. pheromone activity was detectable at a concentration of approximately 5 x 10(-11) m. | 1984 | 6437872 |
| in-vitro activity of enoxacin against aminoglycoside-resistant gram-negative bacilli and other clinical isolates. | the in-vitro activity of enoxacin was tested against 500 clinical isolates of gram-negative bacilli that were resistant to one or more of gentamicin, tobramycin and amikacin, and against 1060 recent consecutive clinical isolates of gram-negative bacilli and gram-positive cocci. enoxacin was active against staphylococci (mics less than or equal to 4 mg/l) but less active against streptococcus faecalis (mics mostly 8 mg/l). it was active against pseudomonas aeruginosa (mics 0.5-4 mg/l) and very ac ... | 1984 | 6438046 |
| antibiotic susceptibility and biochemical properties of streptococcus faecalis strains reacting with both d and g antisera. | thirty one of 60 consecutive isolates of streptococcus faecalis produced a reaction in both d and g streptococcal grouping sera. a close correlation was found between this grouping reaction and haemolysin production, resistance to erythromycin, tetracycline, and trimethoprim, and delayed fermentation of sorbitol. | 1984 | 6438185 |
| a microbiological study of various food premises with an assessment of cleaning and disinfection practices. | a study of cleaning and disinfection methods in a variety of types of catering premises has been carried out. the level of bacterial contamination of the hands and of equipment was related to cleaning methods and to the type of catering establishment. wiping cloths were frequently contaminated with escherichia coli, and these may be important reservoirs of bacteria for contamination of the hands of catering staff. regular and efficient cleaning of food surfaces and equipment was found to be more ... | 1984 | 6438230 |
| endotoxemia in intensive care patients: a longitudinal study with the limulus amebocyte lysate test. | in patients with severe underlying disease and in polytraumatized patients, clinical signs of septicemia caused by infections with gram-negative bacteria are observed postoperatively with increasing frequency. using a photometric lal test, a longitudinal assessment of lal reactivity on 41 intensive care patients was performed. postoperatively, all patients developed a septicemia of different severity with body temperatures greater than 38.5 degrees c. dividing the individual disease course, rela ... | 1984 | 6438389 |
| [concentration profiles of putrescine and cadaverine in inoculated vacuum packed beef]. | the potential of some lactobacillus, staphylococcus and streptococcus strains for producing putrescine and cadavering during growth in vacuum packed beef was studied. throughout the six weeks storage at 4 degrees c the samples were sensorily assessed at regular intervals, and their ph values and diamine contents were determined. the amines were quantified by means of capillary gas chromatography. the putrescine and cadaverine contents remained within the range of the initial values until overt s ... | 1984 | 6438939 |
| [endocarditis due to group d streptococcus (s. bovis and s. faecalis) and tumor of the colon. report of 2 cases]. | 1984 | 6439174 | |
| insertion of intrauterine contraceptive device in a patient with a ventricular septal defect: need for antibiotic prophylaxis. | 1984 | 6439295 | |
| a functional treatment method for interphalangeal pyogenic arthritis. | a treatment plan for pyogenic arthritis has been devised in which the accessory collateral ligaments are resected through radial and ulnar midaxial incisions. the surgical wound is debrided and copiously irrigated with an antibiotic solution, and intravenous antibiotics are instituted before operation and continued after operation. physical therapy is begun within 24 hours of surgery and includes active range of motion (rom) of all joints, dynamic splinting, and hand therapy to ensure both full ... | 1984 | 6439775 |
| participation of macrophages in enhanced in vitro immune interferon (ifn gamma) production with mouse spleen cells. | ifn gamma production in cultures of spleen cells obtained from mice sensitized with th69, a live streptococcus faecalis preparation, was examined to determine how macrophages participate. it was demonstrated that sensitized spleen macrophages participated in enhanced ifn gamma production by t cells at an early stage (0-6 hr) of incubation, and that this production is mainly dependent on ia-bearing macrophages in the reconstitution experiments where different combinations of spleen macrophages an ... | 1984 | 6439980 |
| cross-reactions of polysaccharides of staphylococci and streptococci in antipneumococcal and other antisera. | relationships between chemical structure and immunological specificity, deduced from cross-precipitation with antibodies to polysaccharides of known structure, are drawn for polysaccharides of strains of staphylococci and of groups d and h streptococci. | 1984 | 6440007 |
| the effect of cytotoxic therapy on saliva and oral flora. | oral complications of cytotoxic therapy result from direct mucosal damage and, indirectly, occur as a consequence of immunosuppression. such problems are further exacerbated as a result of associated xerostomia and secondary infection. therefore, the aims of this study were to examine the salivary volume and composition (amylase, iga, and lysozyme) together with the oral carriage of potential pathogens in patients receiving cytotoxic therapy. a pilot study comparing healthy controls with patient ... | 1984 | 6440071 |
| [in vitro antibacterial activity of ciprofloxacin against uropathogenic organisms]. | ciprofloxacin (bay 09867) is a new quinoline derivative. its activity against 537 urinary bacterial isolates was compared with those of ampicillin, amikacin, carbenicillin, cefazolin, cefotaxime, cefoxitin, ceftazidime, nalidixic and oxolinic acids, norfloxacin, trimethoprim, and other antimicrobial agents, when appropriate. it inhibited 90% citrobacter freundii, enterobacter spp., e, coli, klebsiella spp., proteus spp., and serratia spp. at less than or equal to 0.78 microgram/ml. the majority ... | 1984 | 6440583 |
| empyema and splenic abscess in infective endocarditis. | we report a case of empyema secondary to splenic abscess, cured by splenectomy, in the course of an infective endocarditis caused by streptococcus faecalis. | 1984 | 6440868 |
| intraprostatic concentration of ciprofloxacin and its activity against urinary pathogens. | the in-vitro activity of ciprofloxacin against 376 urinary pathogens was determined. the minimal inhibitory concentrations for 90% of the enterobacteriaceae were 0.03-0.23 mg/l, for pseudomonas aeruginosa 0.37 mg/l, for streptococcus faecalis 0.75 mg/l and for staphylococcus aureus 0.92 mg/l. a 100 mg dose of ciprofloxacin was administered intravenously to 25 patients undergoing prostatectomy. the concentrations in prostate and serum were measured at different intervals. peak levels in prostate ... | 1984 | 6440885 |
| [enterococcus as one of the agents of suppurative wound processes (review of the literature)]. | 1984 | 6441069 | |
| [bathing caps and germ shedding of human scalp hair]. | with three groups of 30 test subjects each, having short, medium-long and long hair, as well as with a model test using a woman's wig it was possible to show that by wearing bathing caps the transfer of germs from the scalp hairs to the swimming-pool water can be reduced considerably, either by the isolation of the hairs from water when snugly fitting water-tight bathing caps are used, or by a reduction of the germ-carrying hair surface rinsed by the water, which is always the case, even when us ... | 1984 | 6441382 |
| a new approach for presumptive identification of clinically important streptococci. | several tests, bacitracin, camp, pyroglutamic acid-b-naphthylamide test (pyr test), bile aesculin hydrolysis, salt tolerance and pigment production tests were evaluated for their reliability and speed in presumptive identification of streptococci. bacitracin correctly identified all of the group a streptococci but 5% of other beta haemolytic streptococci were misidentified as group a. the pyr reaction was just as sensitive but more specific for group a streptococci and the results were available ... | 1984 | 6441390 |
| effect of hyperbaric oxyhelium gas on response of bacteria to antimicrobial agents in vitro. | modern diving techniques can require the treatment of infection in an atmosphere of pressurized oxyhelium gas. the antibiotic susceptibility of 16 species and strains (eight genera) of gram-negative bacilli and 3 species and strains (two genera) of gram-positive cocci to each of 21 antimicrobial agents was assessed in air at atmospheric pressure and in oxyhelium gas at an absolute pressure of 7 bar (ca. 709 kpa). a disk diffusion technique was employed, and significantly different results were o ... | 1984 | 6441512 |
| toxicity of microbial products in cell culture. | cytotoxicity of a mixed pyrogen preparation and its components as well as native and radiodetoxified lipopolysacharides (lps) was determined with established hep-2 cell cultures and by measuring plating efficiency. this proved to be more sensitive to the damaging effect of both microbe-containing lps (escherichia coli) and purified lps. microorganisms without this compound (lactobacillus casei, streptococcus faecalis) seem to be more infifferent on cells, even saccharomyces cerevisiae has a mark ... | 1984 | 6441761 |
| [comparative study of the antibacterial activity of water and ether extracts of fosfomycin and azidocillin]. | 1983 | 6441786 | |
| [concept of class in relation to first-generation cephalosporins]. | the authors consider differences in answer of the first generation cephalosporins against several strains of gram-negative and gram-positive bacteria, and suggest a revision of the "class" concept as regards sensitivity response of the above mentioned cephalosporins. | 1984 | 6441962 |
| [results of 3 or 10 days' treatment with nitrofurantoin or cotrimoxazole in urinary infections in children]. | 110 children, affected by uti, were included in this study; 52 of them were treated for 10 days and the remaining 58 for 3 days. both groups were treated with cotrimoxazole or nitrofurantoin. urine cultures were repeated soon after the end of therapy and repeated subsequently for a period of 6 months or of 1 year. there is not a great difference between the results obtained with the 10 days treatment and those of the 3 days treatment. an high percentage of relapses occurred in uti caused by prot ... | 1984 | 6442413 |
| [bacterial flora and its sensitivity to antibiotics in urinary tract infections in children]. | the main bacteria causing urinary tract infections in children we found: enterobacteriaceae (75%), pseudomonas aeruginosa (11,8%), staphylococcus albus k- (5%) and streptococcus faecalis (4%). antibiotic sensitivity of 1362 strains of bacteria isolated from urinary tract of children treated in national research institute of mother and child in 1979-1981 were evaluated. sensitivity on 12 chemiotherapeutics were checked. aminoglycoside antibiotics: tobramycin and gentamycin were found as the most ... | 1984 | 6442420 |
| antibiotic resistance in staphylococcus aureus and streptococci. | 1984 | 6442875 | |
| [the antibacterial action of calcium hydroxide]. | 1984 | 6443066 | |
| [comparison of the activity of netilmicin and gentamicin in vitro on bacteria isolated from the oro-pharynx]. | 1984 | 6443212 | |
| [the dilution method in the determination of bacterial sensitivity to antibiotics]. | 1984 | 6443213 | |
| [bacterial activity and salivary concentration of xanthocycline]. | 1984 | 6443215 | |
| [dynamics of salmonella dying off in river water]. | 1984 | 6443866 | |
| [bacteriological investigations with a new semisynthetic oxy-beta-lactam antibiotic ly 127935 (author's transl)]. | the antimicrobial activity of a new oxy-beta-lactam antibiotic ly 127935 against 1066 strains of gram-negative and gram-positive bacterial was evaluated in comparison to cephalothin. the antibiotic has a very wide spectrum and is exceptionally active, in particular against gram-negative rods. it is also active against multiresistant problem strains found in intensive care units (enterobacter cloacae, serratia marcescens, indole-positive proteus), and proved to be quite effective against pseudomo ... | 1980 | 6445339 |
| clinical trials with cefoperazone in the field of internal medicine in japan. | a total of 466 patients were treated with cefoperazone. the drug was usually administered by drip infusion of 2 to 4 gm/day. therapy was described as markedly effective and moderately effective in 64 of 77 patients (83.1%) treated for urinary tract infections; 253 of 316 patients (80.1%) treated for respiratory infections; 37 of 48 patients (77.1%) treated for liver biliary duct infections; ten of 16 patients (62.5%) treated for septicemia; and seven of nine patients (77.8%) being treated for ot ... | 1980 | 6446392 |
| in vitro activity of a new semisynthetic cephalosporin: cefoperazone. | cefoperazone is a new semisynthetic cephalosporin with excellent antibacterial activity. this study included more than 1,500 clinical isolates whose susceptibility to cefoperazone was determined by minimal inhibitory concentration (mic) and minimal bactericidal concentration (mbc). cefoperazone was highly active against enterobacteriaceae including indolepositive proteus, serratia and enterobacter sp. particularly noteworthy was the high activity of cefoperazone against pseudomonas and acinetoba ... | 1980 | 6446401 |
| in vitro antibacterial activity of a new 1-oxa cephalosporin compound. | the in vitro activity of a unique new 1-oxa cephalosporin beta-lactam antibiotic (ly 127935) was tested against clinical isolates of gram-positive and gram-negative bacteria and compared with the activities of cefoxitin, cefamandole, cephalothin, clindamycin, amikacin, tobramycin, gentamicin, ticarcillin, and carbenicillin. the new compound was observed to have a broad spectrum of antibacterial activity which far exceeded the activity of older cephalosporins against aerobic gram-negative enteric ... | 1980 | 6446810 |
| comparison of in vitro activity of moxalactam (ly127935) with cefazolin, amikacin, tobramycin, carbenicillin, piperacillin, and ticarcillin against 420 blood culture isolates. | to compare the in vitro activity of moxalactam (ly127935), a new broad-spectrum antimicrobial agent, with cefazolin, amikacin, tobramycin, carbenicillin, piperacillin, and ticarcillin, each drug was tested against 420 bacterial isolates from the blood of septic patients. standard broth dilution methods were used to determine minimum inhibitory and bactericidal concentrations. ly127935 was as active as the aminoglycosides against aerobic gram-negative organisms, including pseudomonas aeruginosa, ... | 1980 | 6448577 |
| purification and characterization of the membrane adenosine triphosphatase complex from the wild-type and n,n'-dicyclohexylcarbodiimide-resistant strains of streptococcus faecalis. | we have purified the f1-f0 adenosine triphosphatase complex from wild-type streptococcus faecalis atcc 9790 and an n,n'-dicyclohexylcarbodiimide (dccd)-resistant mutant strain, sf-dcc-8. for preliminary purification of the complex, reconstituted f1-f0, prepared from isolated f1 adenosine triphosphatase and depleted membranes, was extracted with sodium deoxycholate and fractionated by salt precipitation. by means of two-dimensional gel electrophoresis, the f1-f0 complex was purified as a single, ... | 1981 | 6455413 |
| [moxalactam - a beta-lactam antibiotic in the monotherapy of severe infections in surgery. clinico-bacteriological study of 35 patients]. | moxalactam, a new beta-lactam antibiotic, was given to 35 patients at the department of surgery, cantonal hospital, st. gall. the trial period started in april 1980 and ended in october. moxalactam was not combined with any other antibiotic. the clinical course was observed closely and extensive bacteriological, mycological, and pharmacokinetic studies were carried out to evaluate the new antibiotic. most of the patients had an intra-abdominal infectious disease and primary treatment was surgery ... | 1981 | 6456543 |
| aspects of the antibacterial action of diphenyliodonium chloride. | diphenyliodonium chloride was found to be a broad spectrum antimicrobial agent and its activity was affected by ph and inoculum size. its uptake by bacterial cells was langmuirian, and it caused loss of intracellular material. aerobic glucose metabolism and dehydrogenase activity were inhibited. low concentrations of the drug affected the membrane-bound atpase and k transport in streptococcus faecalis. | 1981 | 6457963 |
| folylpoly-gamma-glutamate synthesis by bacteria and mammalian cells. | the purification and properties of folylpolyglutamate synthetase from corynebacterium sp, and some properties of partially purified enzyme from lactobacillus casei, streptococcus faecalis, neurospora crassa, pig liver, and chinese hamster ovary cells, are described. the corynebacterium enzyme catalyzes a mgatp-dependent addition of glutamate to a variety of reduced pteroate and pteroylmono-, di-, and triglutamate substrates, with the concomitant production of mgadp and phosphate. although glutam ... | 1981 | 6458762 |
| clinical study of mezlocillin for the treatment and prevention of postoperative obstetric and gynecological infections. | twenty-one women were given mezlocillin for the treatment or prevention of infections after obstetric and gynecological surgery. ten women had active infections caused by escherichia coli, klebsiella species, proteus mirabilis, pseudomonas aeruginosa, or streptococcus faecalis. they had a 90% rate of recovery after an average of seven days of treatment with 6 to 15 gm/day of mezlocillin. the other 11 women were given mezlocillin prophylactically, 2 gm every 12 hours for seven days. all had good ... | 1982 | 6461413 |
| comparison of the antibacterial activity of norfloxacin (mk 0366, am 715), a new organic acid, with that of other orally absorbed chemotherapeutic agents. | 425 randomly selected, fresh clinical isolates were tested for susceptibility to norfloxacin and other orally absorbed agents, i.e. amoxicillin, ampicillin, carbenicillin (available commercially as the indanyl ester), cefaclor, cinoxacin, erythromycin, nalidixic acid, penicillin g, tetracycline, trimethoprim and co-trimoxazole. the results have shown norfloxacin to be the most potent agent in vitro against representative members of the family enterobacteriaceae, staphylococcus aureus, pseudomana ... | 1982 | 6461606 |
| lactose transport in streptococcus mutans: isolation and characterization of factor iiilac, a specific protein component of the phosphoenolpyruvate-lactose phosphotransferase system. | the transport of lactose in streptococcus mutans is mediated via an inducible phosphoenolpyruvate-lactose phosphotransferase system. this system requires for catalytic activity a membrane fraction (enzyme ii), two general proteins called enzyme i and hpr, and a soluble specific protein termed factor iiilac. this protein factor was purified from s. mutans atcc 27352 by chromatographies on deae-cellulose, hydroxylapatite, ultrogel aca 34, and phosphocellulose. the purified protein migrated as a si ... | 1984 | 6480107 |
| antimicrobial agent susceptibility patterns of bacteria in hospitals from 1971 to 1982. | bacterial susceptibility to 16 commonly used antibiotics was analyzed for a 12-year period (from 1971 to 1982, inclusive). susceptibilities of 5,828,243 strains isolated from a mean of 242 hospitals nationwide and of 194,575 strains isolated at the massachusetts general hospital, boston, mass., and the bronx lebanon hospital center, new york, n.y., were compared. strains of escherichia coli, staphylococcus aureus, haemophilus influenzae, and pseudomonas aeruginosa showed virtually the same susce ... | 1984 | 6490861 |
| chocolate agar, a differential medium for gram-positive cocci. | reactions incurred on chocolate agar by gram-positive cocci were correlated with species identity. darkening and clearing of the medium was usually associated with the species staphylococcus epidermidis, staphylococcus aureus, staphylococcus simulans, and streptococcus faecalis. yellowing of chocolate agar was associated with alpha-hemolytic species of streptococcus. the study demonstrated that reactions occurring on chocolate agar are useful in identifying gram-positive cocci. | 1984 | 6490866 |
| comparison of the in vitro activity of azlocillin and carbenicillin against 856 clinical bacterial isolates. | eight hundred and fifty-six strains of more than ten species: staphylococcus aureus, staphylococcus epidermidis, streptococcus faecalis, escherichia coli, klebsiella spp, proteus mirabilis, proteus vulgaris, enterobacter spp, pseudomonas spp and acinetobacter spp, were tested by the disc diffusion method against azlocillin and carbenicillin. azlocillin was found to be superior to carbenicillin against pseudomonas spp, and more than 90% of the tested strains had minimal inhibitory concentration ( ... | 1984 | 6493580 |
| [study of lincomycin concentrations in hepatocystic duct]. | penetration of lincomycin (lcm) in choledochal and cholecystic bile as well as in the gallbladder tissue and liver tissue was investigated together with bacteria detectable in the bile in order to evaluate basically usefulness of this antibiotic in the treatment of infections of the hepatocystic duct. intravenous drip infusion of lcm 1.5 g (in 500 ml of 5% glucose solution) over 1.5--2 hours resulted in mean drug concentrations of 33.9 and 10.1 micrograms/ml in serum at 2 and 4 hours post start ... | 1984 | 6502929 |
| wide-spectrum antibiotic activity of bovine granulocyte polypeptides. | the antibiotic activity of a polypeptide fraction purified from bovine granulocyte granules was tested against escherichia coli, pseudomonas aeruginosa, salmonella typhimurium, bacillus subtilis, bacillus stearothermophilus, staphylococcus aureus, staphylococcus epidermidis, streptococcus faecalis, streptococcus pyogenes, and clinical isolates of staphylococcus and enterobacter spp. all of these bacterial species were susceptible to the antibiotic polypeptide(s), with mics ranging from 3 to 100 ... | 1984 | 6508268 |
| sensitivity of legionella pneumophila to sunlight in fresh and marine waters. | studies were carried out to assess the sunlight sensitivity of legionella pneumophila suspended in fresh and marine waters. comparison studies on sunlight sensitivity of lake water bacteria, pseudomonas aeruginosa, escherichia coli and streptococcus faecalis, were also undertaken. the effects of full sunlight and polyacrylic-screened sunlight were monitored in the study. results indicate that l. pneumophila cells are slightly more sensitive to sunlight in seawater than in fresh water. enumeratio ... | 1984 | 6508311 |
| [doxycycline in the treatment of non-specific urethritis and/or prostatitis]. | twenty-five men with non-specific urethritis/adnexitis were treated with 200 mg doxycycline monohydrate daily (vibramycin tabs) over a period of 10 days. more than half of the patients suffered from chronic inflammations. microorganisms isolated from urethral secretion and prostate exprimate comprised aerobes, in particular staphylococcus epidermidis and streptococcus faecalis, as well as mycoplasmae, chlamydiae, and anaerobes, mainly bacteroides species and peptostreptococci. fourty percent of ... | 1984 | 6539988 |
| a-16686, a new antibiotic from actinoplanes. ii. biological properties. | a-16686, a new glycoproteide antibiotic obtained from fermentation of an actinoplanes strain, is active against gram-positive aerobic and anaerobic bacteria; mic values ranged from 0.016 to 2.0 micrograms/ml. a-16686 is bactericidal for growing cells of staphylococcus aureus, s. epidermidis, streptococcus faecalis, s. faecium, s. mutans, s. mitis and s. sanguis. there is no cross-resistance with clinically used antibiotics. a-16686, administered subcutaneously, is very effective in experimental ... | 1984 | 6547133 |
| in-vitro antibacterial activity of cefotetan. | the in-vitro activity of cefotetan, a recently developed cephamycin, was investigated under various experimental conditions. the compound showed moderate activity against staphylococcus aureus and streptococcus pyogenes, no activity against pseudomonas aeruginosa and streptococcus faecalis, but a high activity against enterobacteriaceae, including beta-lactamase-producing strains. haemophilus influenzae also was fairly susceptible. the mbc was usually equal to or two- or fourfold higher than mic ... | 1983 | 6573325 |
| the in vitro activity of n-formimidoyl thienamycin compared with other broad-spectrum cephalosporins and with clindamycin and metronidazole. | n-formimidoyl thienamycin is a new semisynthetic beta-lactam antibiotic still awaiting clinical trials. we have investigated the in vitro activity of n-formimidoyl thienamycin against 413 fresh clinical isolates and compared it to other new beta-lactam drugs and to clindamycin and metronidazole in the agar dilution test. all coliforms were inhibited by less than or equal to 1 mg/l and no member of the proteus group was resistant to more than 8 mg/l of n-formimidoyl thienamycin. the mics for pseu ... | 1983 | 6578202 |
| imipenem versus moxalactam in the treatment of serious infections. | imipenem (formerly imipemide, n-formimidoyl thienamycin, or mk0787) was compared to moxalactam in a randomized therapeutic trial involving 39 evaluable patients with serious bacterial infections. of those treated with imipenem, 89% were cured or improved versus 60% for moxalactam (p = 0.06). although mucocutaneous fungal infections occurred in both groups (25 and 10%, respectively), streptococcus faecalis superinfection was seen in two patients in the moxalactam group only. adverse drug reaction ... | 1983 | 6581755 |
| the production of dental plaque and caries by the bacterium streptococcus salivarius in gnotobiotic wag/rij rats. | the abilities of ten strains of streptococcus salivarius to colonize rat molars and to induce caries were determined using mono-infected germ-free rats. scanning electron microscopy revealed the production of micro-colonies and spheroids by strep. salivarius on exposed surfaces of molar teeth, and abundant dense plaque formation in fissures. most strains colonized fissures and smooth surfaces as effectively as streptococcus mutans nctc 10832, yet produced no buccal or lingual lesions. the four k ... | 1984 | 6589986 |
| growth and acid tolerance of human dental plaque bacteria. | pure cultures of representative strains of cariogenic and non-cariogenic plaque bacteria were assessed for their ability to initiate and maintain growth in broths, adjusted to initial ph levels of 7.0, 5.5 or 5.0, and to produce lactic acid from sucrose or glucose in resting-cell suspensions at ph 6.5, 5.0, 4.5 and 4.0. streptococcus mutans, lactobacillus casei and streptococcus faecalis showed greater acid tolerance than strains of streptococcus sanguis, streptococcus salivarius, streptococcus ... | 1984 | 6594096 |
| complement activation in shock associated with a surgically provoked bacteriaemia. | the activation of complement (c) factors in a patient exhibiting an anaphylactoid shock 10 min after the initiation of transurethral coagulation of vesical papillomas was studied. streptococcus faecalis was cultured from he urine before and after the shock and from the blood on two occasions within 2 days after the shock. the shock was associated with a marked but transient complement activation as judged from serial determinations of c3d and c3c by doubledecker rocket immuno electrophoresis and ... | 1983 | 6603095 |
| in vitro antibacterial activity and beta-lactamase stability of e-0702, a new cephalosporin. | the in vitro activity of e-0702 was compared with the in vitro activity of cefotaxime, ceftazidime, moxalactam, and aztreonam against 600 gram-positive and gram-negative aerobic and anaerobic isolates. e-0702 had a minimal inhibitory concentration for 50% of isolates (mic50) of 25 micrograms for staphylococcus aureus, 50 micrograms for staphylococcus epidermidis, and 1.6 to 3.1 micrograms for streptococci, with streptococcus faecalis resistant. e-0702 had mic50s against escherichia coli, klebsie ... | 1983 | 6605718 |
| cholecystitis--etiology and treatment--microbiological aspects. | acute cholecystitis is initially a chemical inflammation, but regularly complicated by bacterial invasion from the gut. escherichia coli, klebsiella and streptococcus faecalis dominate among aerobic bacteria, whereas bacteroides fragilis and clostridia are commonly encountered anaerobes. mixed infections are prevalent. bactibilia occurs in at least 60% of the early stage of acute cholecystitis and is particularly prevalent in the elderly. also, bactibilia is very common in recurrent cholecystiti ... | 1984 | 6610921 |
| comparative in vitro activities of third-generation cephalosporins. | the in vitro susceptibilities of 823 clinical isolates to eight third-generation cephalosporin and cephalosporinlike antibiotics were studied. all eight antibiotics were more active and had broader spectrums of activity against gram-negative bacilli and anaerobes than older derivatives; however, they were less active against gram-positive cocci. cefotaxime sodium, cefmenoxime hydrochloride, ceftriaxone disodium, and ceftizoxime sodium had similar activities. cefoperazone sodium was more active t ... | 1983 | 6615095 |
| moxalactam therapy of serious infections. | twenty-four patients were treated with moxalactam for 25 serious infections. nineteen patients were septicemic and 18 presented severe underlying diseases considered to impair the normal response to bacterial pathogens. all of the pathogens had mics of less than 12 mg/l except one pseudomonas aeruginosa strain with an mic of 32 mg/l. the dosage ranged from 3 to 12 g/day; the route of administration was either i.v. or i.m. the duration of treatment was six to 26 days. six patients had urinary tra ... | 1983 | 6618677 |
| the use of azlocillin to treat serious infections. | azlocillin, a semisynthetic ureidopenicillin that inhibits many gram-negative and gram-positive bacteria and many pseudomonas aeruginosa resistant to carbenicillin, was used to treat 23 episodes of infection in 20 patients. the majority of the patients had severe underlying diseases, including marked reduction in renal function in a number of the patients. infection sites were lung, urinary tract, skin and primary bacteraemia. seven patients had bacteraemia. clinical cure or improvement was achi ... | 1983 | 6619023 |
| cefamandole-erythromycin-heparin peritoneal irrigation: an adjunct to the surgical treatment of diffuse bacterial peritonitis. | the enthusiasm for the use of peritoneal irrigation has waxed and waned since its introduction by dr. pierce in 1905. the purpose of this study was to devise a relatively low-cost irrigant that could be used for continuous intraperitoneal lavage, with the intent of decreasing abscess formation following surgical treatment for generalized bacterial peritonitis. a solution of 1 l of normal saline containing 50 mg erythromycin, 50 mg cefamandole, 500 u heparin, and 5 meq kcl was proven in in vitro ... | 1983 | 6623358 |
| rifampin: spectrum of antibacterial activity. | rifampin was studied for determination of its spectrum of activity against many bacteria of clinical importance. most of the minimum inhibitory concentrations (mics) were determined by agar dilution but some were determined by broth microdilution. staphylococci were the most susceptible, with mode mics of 0.015 microgram/ml, but most streptococcal strains, except streptococcus faecalis, had mode mics less than or equal to 1 microgram/ml. haemophilus influenzae, neisseria gonorrhoeae, neisseria m ... | 1983 | 6635433 |
| in vitro evaluation of three new macrolide antimicrobial agents, ru28965, ru29065, and ru29702, and comparisons with other orally administered drugs. | three new macrolide drugs (ru28965, ru29065, and ru29702) were compared in vitro with erythromycin and five other orally administered antimicrobial agents by using 733 recent clinical isolates. all of the investigational macrolides had a spectrum very similar to that of erythromycin, but with slightly higher (two- to fourfold) minimum inhibitory concentrations against haemophilus influenzae, staphylococci, and streptococci including streptococcus faecalis. ru29065 and ru29702 were more active th ... | 1983 | 6638988 |
| antibacterial activity of dl 473, a c3-substituted rifamycin derivative. | dl 473 is a 3-[(4-cyclopentyl-1-piperazinyl)iminomethyl] rifamycin sv derivative which inhibited staphylococci, streptococci (including streptococcus faecalis, listeria species, and bacteroides species. dl 473 was less active than rifampin against these species. dl 473 did not inhibit enterobacteriaceae nor most pseudomonas species. a combination of dl 473 and vancomycin or nafcillin tested against staphylococci was primarily additive and antagonism was not encountered. | 1983 | 6639006 |
| rapid identification of enterococci. | a 4-h method was devised to differentiate the non-beta-hemolytic streptococci into three categories: enterococci, group d nonenterococci, and viridans streptococci. all of the streptococcus faecalis, 90% of the streptococcus faecium (enterococci), and 96% of the streptococcus bovis biotype i (group d nonenterococci) cultures were correctly identified by the 4-h method. the less commonly isolated group d cultures had lower rates of correct identification by this method. none of the viridans strep ... | 1983 | 6643675 |
| antibacterially active substituted anilides of carboxylic and sulfonic acids. | anilides of carboxylic and sulfonic acids were prepared and tested for antimicrobial activity. while these anilides were ineffective against gram-negative organisms, there was a good correlation between chemical structure and biological activity against gram-positive species. both the nature and position of the benzene ring substituents and the length of the carbon side chain affected the activity and specificity of the compounds. the highest activity was observed when the acyl or sulfuryl moiet ... | 1983 | 6644743 |
| purification of proteins similar to hpr and enzyme i from the oral bacterium streptococcus salivarius. biochemical and immunochemical properties. | the phosphoenolpyruvate:sugar phosphotransferase system (pts) is made of several proteins. two of them are designated general proteins because they are required for the transport and phosphorylation of all sugars of the pts. these two proteins are found in the soluble fraction of cellular extracts and are termed hpr and enzyme i (ei). we reported in this work the purification and the characterization of these two proteins from streptococcus salivarius atcc 25975. hpr was purified by deae-cellulo ... | 1983 | 6673822 |
| [bacterial species recently isolated from urinary tract infections and their antibiotic susceptibility, with special reference to acute cystitis]. | numbers of the strains of each bacterial species isolated from urinary tract infections were summed and their incidences were calculated for each a half year from the second half of 1980 to the first half of 1982. the incidences of escherichia coli strains were found to be greatly reduced and those of streptococcus faecalis strains were greatly increased. those of staphylococcus epidermidis strains were also increased. this trend was thought to be caused by the extensive and exclusive use of cep ... | 1983 | 6674515 |
| thiosemicarbazones of 2-acetylpyridine, 2-acetylquinoline, 1- and 3-acetylisoquinoline and related compounds as inhibitors of clinically significant bacteria in vitro. | antibacterial activity of 64 thiosemicarbazones of 2-acetylpyridine, 2-acetylquinoline, 1- and 3-acetylisoquinoline and related compounds was determined by testing clinical isolates of ten bacterial genera, including some which were antibiotic resistant. minimal inhibitory concentrations (mics) of 0.016 to 0.125 microgram/ml were obtained with 26% of the compounds for neisseria meningitidis and 0.002 to 0.25 microgram/ml with 19% of the compounds for n. gonorrhoeae. staphylococcus aureus was inh ... | 1983 | 6686454 |
| excretion of cefuroxime in biliary disease. | cefuroxime is a broad spectrum b-lactamase stable cephalosporin antibiotic. an intravenous injection of cefuroxime sodium 1.5 grams was administered to 45 patients after induction of anesthesia for cholecystectomy. twenty-five patients had elective operations for chronic cholecystitis and 20 underwent urgent operations for acute cholecystitis. of the 25 patients who underwent elective treatment, the cystic duct was patent in 13 and obstructed in 12. antibiotic concentrations were measured by mic ... | 1984 | 6701741 |
| in vitro activity of ciprofloxacin compared with those of other new fluorinated piperazinyl-substituted quinoline derivatives. | the in vitro antimicrobial activity of ciprofloxacin (bay o 9867) was compared with those of the other new fluorated piperazinyl-substituted quinoline derivatives: norfloxacin, ofloxacin, and pefloxacin, as well as with those of the earlier analogs, nalidixic acid and oxolinic acid. virtually no resistance against the new fluorated piperazinyl-substituted quinoline derivatives was observed. as a rule, ciprofloxacin was about four times more active in vitro than the other new fluorated piperaziny ... | 1984 | 6732221 |
| evaluation of a rapid system for species identification of alpha-hemolytic streptococci. | a new 4-h commercial system (api 20s; analytab products, plainview, n.y.) for the identification of streptococci was compared with the conventional biochemical profile method in the species identification of alpha-hemolytic streptococci. a total of 194 clinical isolates (including 74 isolated from blood cultures, 64 isolated from wound cultures, and 56 isolated from respiratory cultures) and 20 reference strains were tested. only 4 of the 20 reference strains were correctly identified to species ... | 1982 | 6752191 |
| energy coupling to potassium transport in streptococcus faecalis. interplay of atp and the protonmotive force. | we have studied the mechanism by which metabolic energy is coupled to potassium accumulation by the fermentative bacterium, streptococcus faecalis. in starving cells, k+ movements into the cells or out are very slow; even 42k+/k+ exchange requires concurrent metabolism of glucose or arginine. metabolizing cells accumulate k+, establishing a concentration gradient of some 50,000. accumulation is prevented by reagents that block or short circuit the proton circulation, but 42k+/k+ exchange persist ... | 1980 | 6766127 |
| antimicrobial synergism of piperacillin and gentamicin against pseudomonas aeruginosa, staphylococcus aureus and streptococcus faecalis. | the potential synergistic effect of piperacillin with gentamicin was examined against five isolates each of pseudomonas aeruginosa, staphylococcus aureus and streptococcus faecalis isolated from patients with endocarditis. piperacillin and gentamicin synergistically inhibited all strains of p. aeruginosa and s. aureus tested. they exerted no synergistic effect against s. faecalis. piperacillin and gentamicin synergism may be clinically tested in the treatment of serious pseudomonas and staphyloc ... | 1980 | 6766372 |
| antibacterial properties of dilute formocresol and eugenol and propylene glycol. | formocresol and eugenol are the two nonspecific intracanal medicaments commonly used in endodontic practice. both have high tissue irritation potential when used in conventional strength. propylene glycol is an alcohol that is injectable and itself possesses significant antibacterial action. it is a popular vehicle and hence was used to modify the two drugs. standard bacteriologic methods were employed to test the antibacterial action of these lower concentrations of the two drugs against four t ... | 1980 | 6766544 |
| candida meningitis in patients with csf shunts. | two adult patients with csf shunts contracted candida albicans meningitis. in both patients, these infections were either preceded by or occurred simultaneously with bacterial meningitis. treatment with antimicrobials alone failed to sterilize the csf. cure was obtained only after removal of the shunt tubes. the simultaneous or subsequent development of candida meningitis should be considered in selected patients who do not make appropriate recovery from a bacterial meningitis, especially one th ... | 1980 | 6766718 |
| studies of enzyme-mediated reactions. part 12. stereochemical course of the decarboxylation of (2s)-tyrosine to tyramine by microbial, mammalian, and plant systems. | 1980 | 6766946 | |
| antimicrobial effects of trimethoprim and sulphadiazine in infected urine and blood. | sulphadiazine and trimethoprim in a wide range of concentrations were added to urine from patients with untreated urinary-tract infections. at therapeutic concentrations, the antibacterial activity of trimethoprim was not increased by the addition of sulphadiazine. exposure of escherichia coli to trimethoprim in urine was not associated with an increase in resistance to that agent. it was also not possible to select, in vitro, stable resistance to trimethoprim in sensitive cultures of e. coli. a ... | 1980 | 6767033 |
| subacute bacterial endocarditis. | two patients in whom various immunological phenomena obscured and delayed the diagnosis of subacute bacterial endocarditis (sbe) are described. immunological abnormalities usually correlate well with the chronicity and severity of the disease, as is demonstrated here. the mechanisms underlying the various immunological phenomena are discussed. the importance of alertness to the possibility of sbe in cases of disease manifesting itself as an immunological disorder, thus achieving early diagnosis ... | 1980 | 6767284 |
| complement, opsonins, and the immune response to bacterial infection in burned patients. | studies were performed to evaluate complement, opsonins, and the immune response to bacterial infection in burned patients. concentrations and functional acitivities of components of the classical and alternative complement pathways were measured in the sera of four septic, two bacteremic, and four nonseptic burned patients. in addition, heat-labile and heat-stable opsonic activity and agglutinin titers directed against the infecting bacterial strains were measured in the sera of the four septic ... | 1980 | 6767453 |
| ontogeny of the inflammatory response in the fetal rat. | fetal rats of 16, 17 and 18 days gestation (dg) were injected with turpentine or streptococcus faecalis in 1% india ink. specimens of peritoneal tissues and exudates were collected at 24, 48 and 96 h after injection. inflammation was present in some of the youngest animals (16 dg) 24 h after injection with bacteria. the response consisted of infiltrates of polymorphonuclear (pmn) and mononuclear (mn) cells in tissues adjacent to the peritoneum. inflammatory cells were also found within the perit ... | 1980 | 6767506 |
| structure of the nucleoid in cells of streptococcus faecalis. | the structure of the nucleoid of streptococcus faecalis (atcc 9790) was examined and compared in the unfixed and fixed states by immersive refractometry and electron microscopy. it appears from these studies that the nucleoid structure is much more centralized in unfixed chloramphenicol-treated (stationary-phase) cells than it is in cells in the exponential phase of growth. the more dispersed configuration of the exponential-phase nucleoid could be preserved by fixation in glutaraldehyde, but no ... | 1980 | 6767695 |
| visualization of cell-cell contact during conjugation in streptococcus faecalis. | conjugal transfer of an antibiotic resistance plasmid in streptococcus faecalis was associated with direct intercellular connections between chains of streptococci in the absence of either pili or fimbriae. | 1980 | 6767697 |
| a novel mechanism of resistance to penicillin-gentamicin synergism in streptococcus faecalis. | a patient with enterococcal endocarditis, who relapsed after repeated courses of apparently adequate treatment with ampicillin plus gentamicin, was subsequently cured with ampicillin-tobramycin therapy. the organisms isolated from this patient were strains of streptococcus faecalis that were resistant to penicillin (or ampicillin)-gentamicin synergism but not to penicillin (or ampicillin)-tobramycin synergism. the mechanism of resistance in these strains appears to be related to a specific defec ... | 1980 | 6767791 |
| semimicro extraction of ubiquinone and menaquinone from bacteria. | 1980 | 6767895 | |
| [in-vitro efficacy of topical antibiotics on bacteria from burns]. | the influence of topical antimicrobial agents on bacterial growth was determined with an agar diffusion technique. 349 isolates were tested with mafenide acetate and silver sulfadiazine, 226 isolates were tested with povidone iodine. none of these agents was likewise effective against all organisms of the same bacterial strain. the inhibition of growth by mafenide acetate and silver sulfadiazine demonstrated dose-response. 26 to 40% of the tested grampositive cocci were inhibited by mafenide ace ... | 1980 | 6768661 |
| methylenetetrahydrofolate-dependent biosynthesis of ribothymidine in transfer rna of streptococcus faecalis. evidence for reduction of the 1-carbon unit by fadh2. | the methyl carbon of ribothymidine in loop iv of the trna of streptococcus faecalis, bacillus subtilis, and some other microorganisms is derived directly from 5,10-methylenetetrahydrofolate, not s-adenosylmethionine. the pure enzyme from s. faecalis also requires fadh2. we have obtained evidence that tetrahydrofolate is a product of the reaction and demonstrated that label from [5-3h]5-deazafmnh2 is incorporated into the methyl moiety of ribothymidine. these data indicate that the enzyme uses me ... | 1980 | 6768721 |
| the biosynthesis of nascent membrane lipoteichoic acid of streptococcus faecium (s. faecalis atcc 9790) from phosphatidylkojibiosyl diacylglycerol and phosphatidylglycerol. | phosphatidylkojibiosyl diacylglycerol functions as the acceptor of sn-glycerol 1-phosphate moieties from phosphatidylglycerol in the in vitro synthesis of the membrane lipoteichoic acid of streptococcus faecium (s. faecalis atcc 9790). the enzyme catalyzing this polymer-forming reaction is membrane-bound. the majority of the product is water-soluble, is excluded from sepharose 6b, and, after longer incubations, changes to a form that co-precipitates with protein upon exposure to a denaturing age ... | 1980 | 6768734 |
| chromatography of folates on sephadex g-10. | 1980 | 6768962 | |
| conversion of pteroylmonoglutamates into pteroylpolyglutamates. | 1980 | 6768964 | |
| conversion of pteroylmonoglutamates to pterolypolyglutamates. | 1980 | 6768965 | |
| assay of folylpolyglutamate hydrolase using pteroyl-labeled substrates and selective short-term bacterial uptake for product determination. | 1980 | 6768966 | |
| uptake and release of chlorhexidine by bovine pulp and dentin specimens and their subsequent acquisition of antibacterial properties. | bovine pulp and dentin specimens were treated with either a 0.02 or 1.00 percent solution of chlorhexidine for either 20 or 40 minutes. culture determination of the acquisition of antibacterial properties by the treated specimens immediately and 1 week after the treatment was evaluated using the test organism streptococcus faecalis. it was concluded that chlorhexidine is a potent antibacterial agent under the test conditions and that its use as an endodontic irrigating solution should be further ... | 1980 | 6769080 |
| bacterial inhibitory effects of nitrite: inhibition of active transport, but not of group translocation, and of intracellular enzymes. | nitrite inhibited active transport of proline in escherichia coli but not group translocation of sugar via the phosphoenolpyruvate:phosphotransferase system. these results were consistent with previous results that nitrite inhibits active transport, oxygen uptake, and oxidative phosphorylation in aerobic bacteria. nitrite also inhibited aldolase (ec 4.1.2.13) from e. coli, pseudomonas aeruginosa, streptococcus faecalis, and rabbit muscle. thus, these various data showed that nitrite has more tha ... | 1980 | 6769392 |
| the bacterial phosphoenolpyruvate dependent phosphotransferase system (pts): solubilisation and kinetic parameters of the glucose-specific membrane bound enzyme ii component of streptococcus faecalis. | 1980 | 6769709 | |
| transferability of macrolide, lincomycin, and streptogramin resistances between group a, b, and d streptococci, streptococcus pneumoniae, and staphylococcus aureus. | the transferability of plasmid pri405 between various streptococci of groups a, b, and d, streptococcus pneumoniae, and staphylococcus aureus is described. pri405 originated from streptococcus faecalis and encodes for resistance to macrolides, lincomycin, and streptogramin b (mls resistance). the host range of the well-documented streptococcal plasmid pam beta 1 was found to be similar to that of pri405. cleavage with restriction enzymes suggests that pri405 belongs to a related family of mls re ... | 1980 | 6769898 |