Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| bacteriological features of infectious spondylodiscitis at mohammed v military teaching hospital of rabat. | to review the bacteriological features of infectious spondylodiscitis and provide recommendations for the initial therapy which remains empirical in our context. retrospective study including patients diagnosed with spondylodiscitis over a period of 4 years (2006-2009) at the rabat military teaching hospital. during the study period, we analysed 30 cases: the mean age was 49.9 years and 21 cases (70%) were male. the patients were predominantly hospitalized in neurosurgery department (15/30) foll ... | 2012 | 24031960 |
| a combination of improved differential and global rna-seq reveals pervasive transcription initiation and events in all stages of the life-cycle of functional rnas in propionibacterium acnes, a major contributor to wide-spread human disease. | sequencing of the genome of propionibacterium acnes produced a catalogue of genes many of which enable this organism to colonise skin and survive exposure to the elements. despite this platform, there was little understanding of the gene regulation that gives rise to an organism that has a major impact on human health and wellbeing and causes infections beyond the skin. to address this situation, we have undertaken a genome-wide study of gene regulation using a combination of improved differenti ... | 2013 | 24034785 |
| investigation of cultivable bacteria isolated from longstanding retreatment-resistant lesions of teeth with apical periodontitis. | the objective of this research was to investigate the presence of viable bacteria in tissue samples from persistent apical lesions and to correlate the microbiological findings with the histopathological diagnosis of the lesion. | 2013 | 24041384 |
| septic nonunions of lower limb long bones: don't neglect propionibacterium acnes! | we report 3 clinical cases of septic nonunions of lower limb long bones in which the pathogenicity of propionibacterium acnes was retained after several weeks of poor outcome. the patients had fractures that were treated by internal fixation, without initially suspected infection. the diagnosis of delayed union coincided with the onset of treatment. support was performed in 2 steps, allowing for the collection of several deep samples that were referred for microbiological analysis. molecular tec ... | 2013 | 24043669 |
| identification of proteins of propionibacterium acnes for use as vaccine candidates to prevent infection by the pig pathogen actinobacillus pleuropneumoniae. | actinobacillus pleuropneumoniae is the causative agent of acute and chronic pleuroneumonia that is responsible for substantial morbidity and mortality in the pig industry. new improved vaccines that can protect against all serotypes and prevent colonization are required. in a previous study we showed that whole cells of propionibacterium acnes protected pigs from a. pleuropneumoniae serotype 1 and 5 and, therefore, the basis for a promising heterologous vaccine. the aim of this study was to iden ... | 2013 | 24051157 |
| comparative genomics reveals distinct host-interacting traits of three major human-associated propionibacteria. | propionibacteria are part of the human microbiota. many studies have addressed the predominant colonizer of sebaceous follicles of the skin, propionibacterium acnes, and investigated its association with the skin disorder acne vulgaris, and lately with prostate cancer. much less is known about two other propionibacterial species frequently found on human tissue sites, propionibacterium granulosum and propionibacterium avidum. here we analyzed two and three genomes of p. granulosum and p. avidum, ... | 2013 | 24053623 |
| the opportunistic pathogen propionibacterium acnes: insights into typing, human disease, clonal diversification and camp factor evolution. | we previously described a multilocus sequence typing (mlst) scheme based on eight genes that facilitates population genetic and evolutionary analysis of p. acnes. while mlst is a portable method for unambiguous typing of bacteria, it is expensive and labour intensive. against this background, we now describe a refined version of this scheme based on two housekeeping (aroe; guaa) and two putative virulence (tly; camp2) genes (mlst4) that correctly predicted the phylogroup (ia1, ia2, ib, ic, ii, i ... | 2013 | 24058439 |
| the role of inflammation in the pathology of acne. | the conventional perspective of acne pathogenesis holds that propionibacterium acnes colonizes the duct of the sebaceous follicle, causing an innate immune response and the progression from a so-called noninflammatory comedo to an inflammatory papule, pustule, or nodule. however, this viewpoint has come under increasing scrutiny over the last decade, as evidence has emerged supporting a role for inflammation at all stages of acne lesion development, perhaps subclinically even before comedo forma ... | 2013 | 24062871 |
| effects of cosmetics containing purified honeybee (apis mellifera l.) venom on acne vulgaris. | acne vulgaris is a chronic dermatologic problem with multiple factors involved in its pathogenesis. alternative solutions to acne treatment were instigated by antibiotic resistance despite of its extensive use. purified bee venom (pbv) has been proposed as a promising candidate for that purpose. the present study was designed to confirm the antibacterial effect of pbv and access the efficacy of cosmetics containing pbv in subjects with acne vulgaris. | 2013 | 24063779 |
| genotypic and antimicrobial characterisation of propionibacterium acnes isolates from surgically excised lumbar disc herniations. | the anaerobic skin commensal propionibacterium acnes is an underestimated cause of human infections and clinical conditions. previous studies have suggested a role for the bacterium in lumbar disc herniation and infection. to further investigate this, five biopsy samples were surgically excised from each of 64 patients with lumbar disc herniation. p. acnes and other bacteria were detected by anaerobic culture, followed by biochemical and pcr-based identification. in total, 24/64 (38%) patients h ... | 2013 | 24066290 |
| role of probiotics in the prevention and treatment of meticillin-resistant staphylococcus aureus infections. | meticillin-resistant staphylococcus aureus (mrsa) is a multidrug-resistant micro-organism and is the principal nosocomial pathogen worldwide. following initial in vitro experiments demonstrating that lactobacillus acidophilus cl1285(®) and lactobacillus casei lbc80r(®) commercial strains exhibit antibacterial activity against clinical mrsa isolates, we conducted a literature search to find any evidence of probiotic efficacy in decolonisation or treatment of s. aureus infection. as summarised bel ... | 2013 | 24071026 |
| rapid systemic and local treatments with the antibacterial peptide dimer a3-apo and its monomeric metabolite eliminate bacteria and reduce inflammation in intradermal lesions infected with propionibacterium acnes and meticillin-resistant staphylococcus aureus. | when administered intramuscularly, the designer antibacterial peptide dimer a3-apo is highly efficacious in mouse models of acinetobacter baumannii and staphylococcus aureus burn infections. here we compared the efficacy of a3-apo and its monomeric metabolite in mouse models of s. aureus and propionibacterium acnes intradermal infections following administration as intramuscular (i.m.) or topical treatments. in the animal models, either (i) the ears of cd-1 mice were infected with p. acnes or (i ... | 2013 | 24074727 |
| gut microbiota dysbiosis and bacterial community assembly associated with cholesterol gallstones in large-scale study. | elucidating gut microbiota among gallstone patients as well as the complex bacterial colonization of cholesterol gallstones may help in both the prediction and subsequent lowered risk of cholelithiasis. to this end, we studied the composition of bacterial communities of gut, bile, and gallstones from 29 gallstone patients as well as the gut of 38 normal individuals, examining and analyzing some 299, 217 bacterial 16s rrna gene sequences from 120 samples. | 2013 | 24083370 |
| acute post-traumatic endophthalmitis secondary to propionibacterium acnes. | propionibacterium acnes has rarely been reported as the causative organism in acute endophthalmitis following penetrating ocular trauma. we report a 53-year-old man, who presented with best corrected vision of counting fingers at 2 m, <n36, in the right eye and clinical features suggestive of endophthalmitis following penetrating trauma with a tree branch 2 days earlier. conjunctival swab, aqueous and vitreous tap were sent for aerobic, anaerobic and fungal culture. the patient was treated with ... | 2013 | 24096075 |
| icam-1 deficiency exacerbates sarcoid-like granulomatosis induced by propionibacterium acnes through impaired il-10 production by regulatory t cells. | propionibacterium acnes has been implicated as one of the suggested causative antigens for sarcoidosis, a systemic granulomatous disease. by injecting heat-killed p. acnes into the dorsal skin of c57bl/6j mice on days 1, 3, 5, and 14, sarcoid-like granulomatosis was induced in skin and lungs of these mice on day 28. to clarify the role of cell adhesion molecules in cutaneous sarcoidosis, we induced sarcoid-like granulomatosis in mice deficient of intercellular adhesion molecule (icam)-1, l-selec ... | 2013 | 24103557 |
| bacteriological findings in radicular cyst and keratocystic odontogenic tumour fluids from asymptomatic patients. | in this study the potential presence of bacteria in radicular cyst (rc) and keratocystic odontogenic tumour(kcot) fluids from clinically asymptomatic patients was investigated. | 2013 | 24112722 |
| tnfr2 maintains adequate il-12 production by dendritic cells in inflammatory responses by regulating endogenous tnf levels. | sepsis-induced immune reactions are reduced in tnf receptor 2 (tnfr2)-deficient mice as previously shown. in order to elucidate the underlying mechanisms, the functional integrity of myeloid cells of tnfr2-deficient mice was analyzed and compared to wild type (wt) mice. the capacity of dendritic cells to produce il-12 was strongly impaired in tnf-deficient mice, mirroring impaired production of il-12 by wt dendritic cells in sepsis or after lps or tnf pre-treatment. in addition, tnfr2-deficient ... | 2014 | 24122297 |
| pustulotic arthro-osteitis associated with palmoplantar pustulosis. | palmoplantar pustulosis (ppp) is a chronic inflammatory disorder characterized by sterile pustules predominantly involving the palms and soles of middle-aged women. ppp frequently develops or exacerbates following focal infections, such as tonsillitis, odontogenic infection and sinusitis, either with or without arthralgia and/or extra-palmoplantar lesions. pustulotic arthro-osteitis (pao) is a joint comorbidity of ppp, most often affecting the anterior chest wall. pao is sometimes regarded as th ... | 2013 | 24127744 |
| in vitro evaluation of the efficacy of chicken egg yolk antibodies (igy) generated against propionibacterium acnes. | acne vulgaris driven by multiple factors appears in almost two-third of the population. increased resistance of the bacterium to antibiotics and cost-effective treatments have made us resort to alternative therapy. | 2014 | 24131381 |
| should we start treating chronic low back pain with antibiotics rather than with pain medications? | for those of us who have read the 2 recently published articles by a danish - british research group, it might appear that we are observing an impending paradigm shift on the origins of chronic low back pain. the results of this research indicate, that chronic low back pain associated with bone marrow edema in vertebral endplates that are adjacent to herniated intervertebral discs may be caused by infections with anaerobic bacteria of low virulence. according to these articles, treatment with ce ... | 2013 | 24155998 |
| il-1β drives inflammatory responses to propionibacterium acnes in vitro and in vivo. | acne vulgaris is potentially a severe skin disease associated with colonization of the pilo-sebaceous unit by the commensal bacterium propionibacterium acnes and inflammation. p. acnes is considered to contribute to inflammation in acne, but the pathways involved are unclear. here we reveal a mechanism that regulates inflammatory responses to p. acnes. we show that il-1β mrna and the active processed form of il-1β are abundant in inflammatory acne lesions. moreover, we identify p. acnes as a tri ... | 2014 | 24157462 |
| antibacterial and anti-inflammatory effects of syzygium jambos l. (alston) and isolated compounds on acne vulgaris. | acne vulgaris is a chronic skin disorder leading to inflammation as a result of the production of reactive oxygen species due to the active involvement of propionibacterium acnes (p. acnes) in the infection site of the skin. the current study was designed to assess the potential of the leaf extract of syzygium jambos l. (alston) and its compounds for antibacterial and anti-inflammatory activity against the pathogenic p. acnes. | 2013 | 24168697 |
| topical antibiotic monotherapy prescribing practices in acne vulgaris. | the aim of this study is to evaluate the frequency of dosing topical antibiotics as monotherapy in the treatment of acne vulgaris, and physician specialty prescribing these medications. | 2014 | 24171409 |
| prospective clinical evaluation of 1.5% levofloxacin ophthalmic solution in ophthalmic perioperative disinfection. | gram-positive cocci and propionibacterium acnes are widely reported agents of infectious postoperative endophthalmitis. this multicenter study was conducted to evaluate the eradication effectiveness and safety profile of levofloxacin 1.5% ophthalmic solution (lvfx 1.5%) for use in perioperative disinfection. | 2013 | 24180629 |
| [antibiotic prophylaxis in open fractures]. | the administration of antibiotics is now generally accepted as a prophylactic treatment of infection in compound fractures. nevertheless the question is not completely resolved and many problems are still to be discussed.the efficacy of antibiotherapy in this field has just been recently demonstrated ; with the animals by worlock et al. (1988) using an experimental rabbit model, and clinically by braul et al. (1987) which randomized 87 patients with open fractures to receive either cloxacillin o ... | 1995 | 24193267 |
| periprosthetic joint infections treated with two-stage revision over 14 years: an evolving microbiology profile. | late periprosthetic joint infection (pji) occurs in 0.3%-1.7% of total hip arthroplasties (thas) and 0.8%-1.9% of total knee arthroplasties (tkas). surgical debridement, explant, and appropriate antibiotics are imperative for successful treatment. we analyzed organisms from pjis at one institution for temporal trends over 14 years. poisson regression model demonstrated a linear increase in infection rate for the following bacteria as the primary organism: mrsa (incidence rate ratio [irr] = 1.11, ... | 2014 | 24199997 |
| antioxidant and antibacterial activities of vegetables and fruits commonly consumed in thailand. | the vegetables and fruits commonly consumed in thailand have been suggested as rich sources of beneficial phytochemicals. in this study, vegetables and fruits native to the northeast region of thailand were evaluated for antioxidant and antibacterial activities. for vegetables, the extracts of limnophila aromatica (lamk.) merr. (extracted by 80% ethanol) and sauropus androgynus (linn.) merr. (extracted by distilled water) were found to have significant levels of antioxidant activities measured b ... | 2012 | 24205757 |
| effect of introduction of antibiotic-impregnated shunt catheters on cerebrospinal fluid shunt infection in children: a large single-center retrospective study. | infection after both primary and revision shunt surgeries remains a major problem in pediatric neurosurgical practice. antibiotic-impregnated shunt (ais) tubing has been proposed to reduce infection rates. the authors report their experience with ais catheters in their large pediatric neurosurgery department. | 2014 | 24206346 |
| validation of an automated blood culture system for sterility testing of cell therapy products. | automated blood culture systems are widely used for the detection of microorganisms in cell therapy products. however, they are not validated by the manufacturers for this purpose. the aim of this study was to assess the ability of the bactec system (becton-dickinson, le pont-de-claix, france) to detect the microorganisms that could contaminate cell therapy products. | 2014 | 24210785 |
| antibacterial activity of long-chain polyunsaturated fatty acids against propionibacterium acnes and staphylococcus aureus. | new compounds are needed to treat acne and superficial infections caused by propionibacterium acnes and staphylococcus aureus due to the reduced effectiveness of agents used at present. long-chain polyunsaturated fatty acids (lc-pufas) are attracting attention as potential new topical treatments for gram-positive infections due to their antimicrobial potency and anti-inflammatory properties. this present study aimed to investigate the antimicrobial effects of six lc-pufas against p. acnes and s. ... | 2013 | 24232668 |
| volatile ketones from interdigital glands of black-tailed deer,odocileus hemionus columbianus. | three volatile ketones, 2-tridecanone, (e)-3-tridecen-2-one and (e)-4-tridecen-2-one were identified in interdigital gland extracts from black-tailed deer,odocoileus hemionus columbianus. the major compound, (e)-3-tridecen-2-one, inhibited the growth of several species of fungi and grampositive bacteria. the bacterium,propionibacterium acnes, and the fungus,trichophyton mentagrophytes required a minimum concentration (mic) of 12.5 µg/ml and 25 µg/ml, respectively, for inhibition, (e)-3-tridecen- ... | 1995 | 24233672 |
| the role of the skin barrier in modulating the effects of common skin microbial species on the inflammation, differentiation and proliferation status of epidermal keratinocytes. | skin resident microbial species are often thought of either as pathogenic or commensal. however, little is known about the role of the skin barrier in modulating their potential for causing disease. to investigate this question we measured the effects of three microbial species commonly found on the skin (staphylococcus epidermidis, staphylococcus aureus, and propionibacterium acnes) on a reconstructed human epidermal model by either applying the bacteria on the model surface (intact barrier) or ... | 2013 | 24245826 |
| the effectiveness of enzymic irrigation in removing a nutrient-stressed endodontic multispecies biofilm. | to establish a nutrient-stressed multispecies model biofilm and investigate the dynamics of biofilm killing and disruption by 1% trypsin and 1% proteinase k with or without ultrasonic activation. | 2014 | 24246147 |
| thiazolidinedione derivatives as novel agents against propionibacterium acnes biofilms. | the aim of the present study was to determine the effect of two thiazolidinedione derivatives on propionibacterium acnes biofilm formation in vitro and to assess their effect on the susceptibility of p. acnes biofilms towards antimicrobials. | 2014 | 24251377 |
| staphylococcus epidermidis in the human skin microbiome mediates fermentation to inhibit the growth of propionibacterium acnes: implications of probiotics in acne vulgaris. | increasing evidence demonstrates that commensal microorganisms in the human skin microbiome help fight pathogens and maintain homeostasis of the microbiome. however, it is unclear how these microorganisms maintain biological balance when one of them overgrows. the overgrowth of propionibacterium acnes (p. acnes), a commensal skin bacterium, has been associated with the progression of acne vulgaris. our results demonstrate that skin microorganisms can mediate fermentation of glycerol, which is na ... | 2014 | 24265031 |
| functions of the skin microbiota in health and disease. | the skin, the human body's largest organ, is home to a diverse and complex variety of innate and adaptive immune functions. despite this potent immune system present at the cutaneous barrier, the skin encourages colonization by microorganisms. characterization these microbial communities has enhanced our knowledge of the ecology of organisms present in normal skin; furthermore, studies have begun to bring to light the intimate relationships shared between host and resident microbes. in particula ... | 2013 | 24268438 |
| ubiquitous distribution of phosphatidylinositol phosphate synthase and archaetidylinositol phosphate synthase in bacteria and archaea, which contain inositol phospholipid. | in eukarya, phosphatidylinositol (pi) is biosynthesized from cdp-diacylglycerol (cdp-dag) and inositol. in archaea and bacteria, on the other hand, we found a novel inositol phospholipid biosynthetic pathway. the precursors, inositol 1-phosphate, cdp-archaeol (cdp-aroh), and cdp-dag, form archaetidylinositol phosphate (aip) and phosphatidylinositol phosphate (pip) as intermediates. these intermediates are dephosphorylated to synthesize archaetidylinositol (ai) and pi. to date, the activities of ... | 2014 | 24269814 |
| analysis of bacterial flora associated with peri-implantitis using obligate anaerobic culture technique and 16s rdna gene sequence. | to analyze and characterize the predominant bacterial flora associated with peri-implantitis by using culture techniques under obligate anaerobic conditions and 16s rdna gene sequences. | 2013 | 24278920 |
| azelaic acid: properties and mode of action. | acne is a common skin disorder that can be problematic for adults as well as for adolescents. it has several key pathophysiological features such as follicular hyperkeratosis, elevated propionibacterium acnes proliferation, and reactive inflammation, all of which should be targeted for an optimal outcome. azelaic acid (aza) has profound anti-inflammatory, antioxidative effects, and is bactericidal against a range of gram-negative and gram-positive microorganisms as well, including antibiotic-res ... | 2014 | 24280644 |
| anti-bacterial and anti-inflammatory properties of capric acid against propionibacterium acnes: a comparative study with lauric acid. | propionibacterium acnes (p. acnes) is a commensal bacterium which is possibly involved in acne inflammation. the saturated fatty acid, lauric acid (c12:0) has been shown to possess antibacterial and anti-inflammatory properties against p. acnes. little is known concerning the potential effects of its decanoic counterpart, capric acid (c10:0). | 2014 | 24284257 |
| evaluation of antibacterial and anti-inflammatory activities of less polar ginsenosides produced from polar ginsenosides by heat-transformation. | ginsenosides are the major active constituents in both white and red american ginseng (ag), and their pharmacological effects on central nervous, cardiovascular, and endocrine systems have been well elucidated. however, the anti-propionibacterium acnes (p. acnes) activity of them is still unknown. in this study, 5 ginsenosides enriched fractions were obtained from the total ginsenosides extract of ag roots (tag) by resin adsorption and heat-transformation. resin purification decreased the total ... | 2013 | 24289140 |
| chronic propionibacterium acnes prosthesis joint infection manifesting as a large abscess with gas, without prosthesis loosening. | 2013 | 24306630 | |
| propionibacterium acnes: an underestimated pathogen in implant-associated infections. | the role of propionibacterium acnes in acne and in a wide range of inflammatory diseases is well established. however, p. acnes is also responsible for infections involving implants. prolonged aerobic and anaerobic agar cultures for 14 days and broth cultures increase the detection rate. in this paper, we review the pathogenic role of p. acnes in implant-associated infections such as prosthetic joints, cardiac devices, breast implants, intraocular lenses, neurosurgical devices, and spine implant ... | 2013 | 24308006 |
| ommaya reservoir infections: a 16-year retrospective analysis. | ommaya reservoirs (omr) are used in the treatment of cancer yet risk factors and outcome of infection are not well characterized. we therefore examined our experience with this device. | 2014 | 24321561 |
| bacterial skin commensals and their role as host guardians. | recent years' investigations of the co-evolution and functional integration of the human body and its commensal microbiota have disclosed that the microbiome has a major impact on physiological functions including protection against infections, reaction patterns in the immune system, and disposition for inflammation-mediated diseases. two ubiquitous members of the skin microbiota, the gram-positive bacteria staphylococcus epidermidis and propionibacterium acnes, are predominant on human epitheli ... | 2014 | 24322878 |
| postoperative spine and veptr infections in children: a case-control study. | surgical site infection (ssi) after pediatric scoliosis surgery is a major cause of morbidity. we compared the odds ratios of various potential risk factors for infection among patients who developed a deep ssi following spinal deformity surgery and those who remained infection free. | 2014 | 24327165 |
| physicochemical properties and anti-propionibacterium acnes activity of film-forming solutions containing alpha-mangostin-rich extract. | the objective of this study was to study the effect of formulation compositions on physicochemical properties and anti-propionibacterium acnes activity of film-forming solutions containing alpha-mangostin-rich extract (am). film-forming solution bases and film-forming solutions containing am were prepared by using eudragit rl po or klucel lf or combinations of them as film-forming polymers. rheological properties, ph values of the solutions, and mechanical properties of the dry films were invest ... | 2014 | 24327275 |
| 5α-androst-16-en-3α-ol β-d-glucuronide, precursor of 5α-androst-16-en-3α-ol in human sweat. | 5α-androst-16-en-3α-ol (α-androstenol) is an important contributor to human axilla sweat odor. it is assumed that α-andostenol is excreted from the apocrine glands via a h2 o-soluble conjugate, and this precursor was formally characterized in this study for the first time in human sweat. the possible h2 o-soluble precursors, sulfate and glucuronide derivatives, were synthesized as analytical standards, i.e., α-androstenol, β-androstenol sulfates, 5α-androsta-5,16-dien-3β-ol (β-androstadienol) su ... | 2013 | 24327440 |
| role of propionibacterium acnes in sarcoidosis: a meta-analysis. | to evaluate the available molecular evidence on the possible role of propionibacterium acnes (p. acnes) in the development of sarcoidosis, the meta-analysis was performed. | 2013 | 24351617 |
| draft genome sequences of two strains of propionibacterium acnes isolated from radical prostatectomy specimens. | propionibacterium acnes is a gram-positive bacterium that is closely associated with various parts of the human body, in particular with sebaceous follicles of the skin. it has also been frequently isolated from diseased human prostates. here, we report draft genome sequences of two p. acnes strains, p6 and pa2, isolated from radical prostatectomy specimens. | 2013 | 24356837 |
| cultivable internal bacterial flora of ticks isolated in hungary. | from six sampling sites in north-western hungary 126 questing ticks of three species (ixodes ricinus, dermacentor reticulatus, haemaphysalis concinna) were sampled. after inactivating the external bacteria on the surface of ticks, the internal bacterial flora was cultured (two kinds of agar media at three temperatures with aerobic and anaerobic conditions were applied), and 116 strains were isolated. our results showed, that after a blood meal the bacterial contamination of ticks was much higher ... | 2014 | 24366635 |
| l5-s1 achromobacter xylosoxidans infection secondary to oxygen-ozone therapy for the treatment of lumbosacral disc herniation: a case report and review of the literature. | case report and literature review. | 2014 | 24384664 |
| inhibitory effect of chlorophyllin on the propionibacterium acnes-induced chemokine expression. | chlorophyllin (chl), a chlorophyll-derivative, exhibits several beneficial properties, including antibacterial, antioxidant, and anticancer activities. however, its antibacterial and anti-inflammatory activities against propionibacterium acnes have not been described. the antibacterial activity of this compound was evaluated in vitro using the broth microdilution method. chl had an inhibitory effect on the growth of p. acnes (mic = 100 μm). in a real-time reverse transcription-polymerase chain r ... | 2013 | 24385363 |
| the microbiome of the middle meatus in healthy adults. | rhinitis and rhinosinusitis are multifactorial disease processes in which bacteria may play a role either in infection or stimulation of the inflammatory process. rhinosinusitis has been historically studied with culture-based techniques, which have implicated several common pathogens in disease states. more recently, the nih human microbiome project has examined the microbiome at a number of accessible body sites, and demonstrated differences among healthy and diseased patients. recent dna-base ... | 2013 | 24386477 |
| il-17: a key player in the p. acnes inflammatory cascade? | recent advances in our understanding of inflammatory skin diseases now afford an opportunity to delve deeper into microbial/host interactions in acne. agak et al. report that propionibacterium acnes induces il-17 expression in peripheral blood mononuclear cells and present new evidence that il-17+ cells are found in the perifollicular infiltrate of comedones. additional studies are needed to assess the clinical relevance of il-17 in acne. | 2014 | 24424453 |
| new insights into acne pathogenesis: propionibacterium acnes activates the inflammasome. | the precise contribution of the commensal bacterium propionibacterium acnes (p. acnes) in the inflammatory response associated with acne vulgaris remains controversial. in this issue qin et al. show that p. acnes induces robust il-1β secretion in monocytic cells by triggering the activation of the nlrp3 inflammasome. in vivo, the encounter of p. acnes and macrophages in the peri-follicular dermis could locally result in the release of substantial amounts of il-1β and therefore exacerbate inflamm ... | 2014 | 24424454 |
| successful treatment in a case of propionibacterium acnes-associated sarcoidosis with clarithromycin administration: a case report. | sarcoidosis is recognized as a multiorgan disorder characterized by the presence of non-caseating granulomas in the involved tissues. it has been suggested that sarcoidosis might be due to the exposure to infectious or non-infectious agents in genetically susceptible individuals. in particular, propionibacterium acnes and mycobacterium tuberculosis have been considered causative microorganisms. we report a case of p. acnes-associated sarcoidosis in which a drastic improvement was achieved with c ... | 2014 | 24428939 |
| specific humoral immune response induced by propionibacterium acnes can prevent actinobacillus pleuropneumoniae infection in mice. | porcine contagious pleuropneumonia, caused by actinobacillus pleuropneumoniae, has a major impact on economics, ecology, and animal welfare in the pig-rearing industry. propionibacterium acnes, a facultative anaerobic gram-positive corynebacterium, exists widely in normal healthy adult animals. we have shown previously that p. acnes can prevent a. pleuropneumoniae infections in mice and pigs. to elucidate the mechanism of this effect and to identify novel a. pleuropneumoniae vaccines, the role o ... | 2014 | 24429068 |
| propionibacterium acnes in human health and disease. | 2013 | 24455697 | |
| late-onset capsular block syndrome: unusually delayed presentation. | capsular block syndrome (cbs) has been known to occur as a rare complication of cataract surgery with continuous curvilinear capsulorhexis and a posterior-chamber lens implant. typically, it presents with reduced vision in the early postoperative period and is characterised by a forward displacement of the posterior-chamber intra-ocular lens and an accumulation of intra-capsular opaque material. management of cbs is usually by nd:yag laser capsulotomy. in this report, we describe a unique case o ... | 2013 | 24474932 |
| microbiology of hidradenitis suppurativa (acne inversa): a histological study of 27 patients. | hidradenitis suppurativa (acne inverse) (hs) is a chronic skin disease primarily affecting hair follicles. the aetiology of hs is unknown, but infection is believed to play some role. this retrospective study investigated the microbial colonization directly in skin appendices in hs skin samples. archival samples from 27 patients with hs were screened by immunofluorescence labelling with monoclonal and polyclonal antibodies against gram-positive bacteria, propionibacterium acnes and propionibacte ... | 2014 | 24475943 |
| de novo meningitis caused by propionibacterium acnes in a patient with metastatic melanoma. | propionibacterium acnes is a known cause of postneurosurgical meningitis; however, it is rarely implicated in de novo meningitis. herein we report a case of a 49-year-old male with de novo meningitis caused by p. acnes with metastatic melanoma as the only identified risk factor for his infection. | 2014 | 24478417 |
| antibacterial activity of plumbagin derivative-rich plumbago indica root extracts and chemical stability. | the extraction studies and a one-step purification of the crude extract of plumbago indica using silica-gel vacuum chromatography provided a plumbagin derivative-rich p. indica root extract (ppe). the ppe was standardised to contain total plumbagin derivatives not less than 13% w/w. antibacterial activities of the standardised ppe and three naphthoquinones, plumbagin, elliptinone and 3,3'-biplumbagin, against propionibacterium acnes, staphylococcus aureus and staphylococcus epidermidis were eval ... | 2014 | 24483166 |
| bacteriological evaluation of tonsillar microbial flora according to age and tonsillar size in recurrent tonsillitis. | although numerous studies based on the bacteriology of the tonsil have been carried out, none of them analyzed the variation of tonsillar flora with respect to both age and tonsillar size. the purpose of this study was to isolate the facultative and obligate anaerobes both from the surface and the core of tonsils in recurrent tonsillitis as well as to analyze the variation of isolated bacterial strains according to age and tonsillar size. a prospective study was performed on 111 patients who und ... | 2014 | 24487459 |
| the protective effects of melittin on propionibacterium acnes-induced inflammatory responses in vitro and in vivo. | melittin is the main component in the venom of the honey bee (apis mellifera). it has multiple effects including antibacterial, antiviral, and anti-inflammatory activities in various cell types. however, the anti-inflammatory mechanisms of melittin have not been elucidated in propionibactierium acnes (p. acnes)-induced keratinocyte or inflammatory skin disease animal models. in this study, we examined the effects of melittin on the production of inflammatory cytokines in heat-killed p. acnes-ind ... | 2014 | 24496237 |
| antibiotics may be useful in the treatment of sapho syndrome. | 2014 | 24506659 | |
| outcome and treatment of postoperative spine surgical site infections: predictors of treatment success and failure. | surgical site infection (ssi) is an important complication after spine surgery. the management of ssi is characterized by significant variability, and there is little guidance regarding an evidence-based approach. the objective of this study was to identify risk factors associated with treatment failure of ssi after spine surgery. | 2014 | 24510397 |
| inflammasome activation by propionibacterium acnes: the story of il-1 in acne continues to unfold. | insights into the immune mechanisms at play in skin diseases including acne continue to be made. in this issue, kistowska et al. confirm that propionibacterium acnes activates inflammasomes leading to the production of il-1β and they further identify putative mechanisms by which this process occurs. these data raise interesting questions regarding a multipronged approach by which p. acnes elicits inflammation in early versus late acne and putative differences in the effects of il-1α and il-1β in ... | 2014 | 24518111 |
| relationship between the severity of acne vulgaris and antimicrobial resistance of bacteria isolated from acne lesions in a hospital in japan. | propionibacterium acnes and staphylococcus epidermidis are normal skin inhabitants that are frequently isolated from lesions caused by acne, and these micro-organisms are considered to contribute to the inflammation of acne. in the present study, we examined the antimicrobial susceptibilities and resistance mechanisms of p. acnes and s. epidermidis isolated from patients with acne vulgaris in a university hospital in japan from 2009 to 2010. additionally, we analysed the relationship between the ... | 2014 | 24523159 |
| acne, quorum sensing and danger. | propionibacterium acnes is a ubiquitous skin commensal bacterium, which is normally well tolerated by the immune system in healthy human skin. however, there is increasing evidence to suggest a pivotal role for p. acnes in the inflammatory process underlying the acne pathogenesis. with its features of inflammation and pustulation, acne vulgaris resembles the skin's normal reaction to bacterial pathogens. p. acnes flourishes when sebum production increases in the follicles. bacteria may undergo b ... | 2014 | 24524558 |
| propionibacterium acnes biofilm endocarditis requiring radical cardiac debridement and prosthetic valve replacements. | 2015 | 24529191 | |
| severe inflammation associated with synovitis, acne, pustulosis, hyperostosis, osteitis (sapho) syndrome was markedly ameliorated by single use of minocycline. | we describe the case of a 63-year-old female who presented with severe inflammatory spondylitis, refractory to various antibiotics. mycobacterial and fungal osteomyelitis were unlikely. although asymptomatic, she also had osteomyelitis in the sternocostoclavicular region, and was suspected of having synovitis, acne, pustulosis, hyperostosis, osteitis (sapho) syndrome, against which minocycline showed marked efficacy. the presence of severe inflammatory sapho, albeit rare, together with the marke ... | 2014 | 24533553 |
| anti-inflammatory effects of anthocyanins-rich extract from bilberry (vaccinium myrtillus l.) on croton oil-induced ear edema and propionibacterium acnes plus lps-induced liver damage in mice. | bilberry (vaccinium myrtillus l.) has been known to play a protective role in human health due to its high anthocyanin content. this study investigated the anti-inflammatory effects of bilberry extract (be, containing 42.04% anthocyanin) on propionibacterium acnes (p. acnes) plus lipopolysaccharide (lps) induced liver injury and croton oil-induced ear edema in mice. results showed that be could effectively inhibit croton oil-induced ear edema and liver inflammation provoked by p. acnes plus lps, ... | 2014 | 24548119 |
| interkingdom transfer of the acne-causing agent, propionibacterium acnes, from human to grapevine. | here, we report the surprising and, to our knowledge, unique example of horizontal interkingdom transfer of a human opportunistic pathogen (propionibacterium acnes) to a crop plant (the domesticated grapevine vitis vinifera l.). humans, like most organisms, have established a long-lasting cohabitation with a variety of microbes, including pathogens and gut-associated bacteria. studies which have investigated the dynamics of such associations revealed numerous cases of bacterial host switches fro ... | 2014 | 24554779 |
| a preliminary report on the use of antibiotic-impregnated methyl methacrylate in salvage cranioplasty. | in the setting of recurrent infection and multiple failed reconstruction attempts, the choice of the ideal reconstructive material for salvage cranioplasty remains a source of controversy in the literature. the purpose of this study is to establish the safety and utility of antibiotic-impregnated polymethyl methacrylate (pmma) for salvage cranioplasty.a prospectively maintained database of all patients who underwent salvage cranioplasty using vancomycin and tobramycin-impregnated methyl methacry ... | 2014 | 24561365 |
| propionibacterium acnes prosthetic valve endocarditis with abscess formation: a case report. | endocarditis due to propionibacterium acnes is a rare disease. scant data on treatment of these infections is available and is based on case reports only. if the disease is complicated by abscess formation, surgical intervention combined with an antibiotic therapy might improve clinical outcome. in some cases, cardiac surgeons are reluctant to perform surgery, since they consider the intervention as high risk. therefore, a conservative therapy is required, with little, if any evidence to choose ... | 2014 | 24568204 |
| clonality and anatomic distribution on the skin of antibiotic resistant and sensitive propionibacterium acnes. | increasing antibiotic resistance in the population of propionibacterium acnes is a major concern. our aims were to examine the clonal relationships and anatomical distribution of resistant and sensitive p. acnes. a collection of 350 p. acnes isolates was therefore used to determine the minimum inhibitory concentration of tetracycline, erythro-mycin and clindamycin, multilocus sequence type, and the identity of genetic resistance markers. two hitherto unknown resistance mutations were detected. r ... | 2014 | 24577497 |
| bone and joint infections due to anaerobic bacteria: an analysis of 61 cases and review of the literature. | the diagnosis of anaerobic bone and joint infections (bji) were underestimated before the advent of molecular identification and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (maldi-tof ms). we report 61 cases of anaerobic infections based on our 4-year experience with the management of bji. a total of 75% of cases were post-surgical infections, associated with osteosynthesis devices (65%). early infections occurred in 27% of cases, delayed infections in 17.5% of c ... | 2014 | 24577953 |
| intracellular propionibacterium acnes infection in glandular epithelium and stromal macrophages of the prostate with or without cancer. | recent reports on propionibacterium acnes (p. acnes) suggest that this bacterium is prevalent in the prostate, is associated with acute and chronic prostatic inflammation, and might have a role in prostate carcinogenesis. | 2014 | 24587325 |
| propionibacterium acnes and staphylococcus lugdunensis cause pyogenic osteomyelitis in an intramedullary nail model in rabbits. | propionibacterium acnes and coagulase-negative staphylococci (cons) are opportunistic pathogens implicated in prosthetic joint and fracture fixation device-related infections. the purpose of this study was to determine whether p. acnes and the cons species staphylococcus lugdunensis, isolated from an "aseptically failed" prosthetic hip joint and a united intramedullary nail-fixed tibial fracture, respectively, could cause osteomyelitis in an established implant-related osteomyelitis model in rab ... | 2014 | 24599975 |
| adhesion of anaerobic bacteria to platelet containers. | anaerobic propionibacterium acnes and staphylococcus saccharolyticus are frequently isolated during platelet screening with anaerobic culture methods. although neither p. acnes nor s. saccharolyticus proliferates during platelet storage, both species survive well in this environment. this study was aimed at determining whether strains of p. acnes and/or s. saccharolyticus form surface-attached bacterial cell aggregates, known as biofilms, under platelet storage conditions. we report that these o ... | 2014 | 24602052 |
| optic neuropathy caused by propionibacterium acnes pachymeningitis. | we describe a patient with vision loss from an optic neuropathy caused by propionibacterium acnes pachymeningitis. the patient's optic neuropathy was stabilized with appropriate antibiotic therapy. | 2014 | 24614085 |
| influence of different additives and their concentrations on corneal toxicity and antimicrobial effect of benzalkonium chloride. | the aim of this study was to examine the ophthalmic additives responsible for modulating acute corneal epithelial toxicity induced by benzalkonium chloride (bac) and investigate the ability of polyoxyethylene hydrogenated castor oil 40 (hco-40) and polysorbate 80 (ps-80) to reduce the corneal toxicity and antimicrobial effects of bac. | 2014 | 24619166 |
| routine testing for anaerobic bacteria in cerebrospinal fluid cultures improves recovery of clinically significant pathogens. | in north america, the widespread use of vaccines targeting haemophilus influenzae type b and streptococcus pneumoniae have dramatically altered the epidemiology of bacterial meningitis, while the methodology for culturing cerebrospinal fluid (csf) specimens has remained largely unchanged. the aims of this study were 2-fold: to document the current epidemiology of bacterial meningitis at a tertiary care medical center and to assess the clinical utility of routinely querying for anaerobes in csf c ... | 2014 | 24622102 |
| use of a recombinant cysteine proteinase from leishmania (leishmania) infantum chagasi for the immunotherapy of canine visceral leishmaniasis. | a recombinant cysteine proteinase from leishmania (leishmania) infantum chagasi (rldccys1) was previously shown to induce protective immune responses against murine and canine visceral leishmaniasis. these findings encouraged us to use rldccys1 in the immunotherapy of naturally infected dogs from teresina, piauí, a region of high incidence of visceral leishmaniasis in brazil. | 2014 | 24625516 |
| lps and inactivated propionibacterium acnes elicit a partially protective response in primary infections of heligmosomoides polygyrus. | intestinal helminth infections are common and of paramount economic importance in domestic animals. available chemotherapy is limited and anthelmintic resistance is widespread in some hosts. this scenario favors the exploration of alternative methods of control, among them immune modulators. the effect of escherichia coli lps+propionibacterium acnes on a primary infection of heligmosomoides polygyrus (trichostongyloidea) in mice has been tested. nematode infection induced a rise of specific igg1 ... | 2014 | 24636785 |
| an exploratory study of microbial diversity in sinus infections of cystic fibrosis patients by molecular methods. | for the first time microorganisms in cf sinuses are investigated by molecular methods in response to an absence of anaerobes in cf sinus samples during a two-year period at the copenhagen cf center. | 2014 | 24636809 |
| in search of a candidate pathogen for giant cell arteritis: sequencing-based characterization of the giant cell arteritis microbiome. | to characterize the microbiome of the temporal artery in patients with giant cell arteritis (gca), and to apply an unbiased and comprehensive shotgun sequencing-based approach to determine whether there is an enrichment of candidate pathogens in the affected tissue. | 2014 | 24644069 |
| sensitivity of frozen section histology for identifying propionibacterium acnes infections in revision shoulder arthroplasty. | propionibacterium acnes is a clinically relevant pathogen with total shoulder arthroplasty. the purpose of this study was to determine the sensitivity of frozen section histology in identifying patients with propionibacterium acnes infection during revision total shoulder arthroplasty and investigate various diagnostic thresholds of acute inflammation that may improve frozen section performance. | 2014 | 24647499 |
| frozen section histology: a new tool to identify propionibacterium acnes infections in revision shoulder arthroplasty. commentary on an article by matthew j. grosso, bs, et al., "sensitivity of frozen section histology for identifying propionibacterium acnes infections in revision shoulder arthroplasty". | 2014 | 24647516 | |
| propionibacterium acnes, an emerging pathogen: from acne to implant-infections, from phylotype to resistance. | propionibacterium acnes colonizes the lipid-rich sebaceous glands of the skin. this preferential anaerobic bacterium is easily identified if cultures are prolonged. it is involved in the inflammation process of acne, but until recently, it was neglected in other clinical presentations. despite a reported low virulence, the new genomic, transcriptomic, and phylogenetic studies have allowed better understanding of this pathogen's importance that causes many chronic and recurrent infections, includ ... | 2014 | 24656842 |
| pro-inflammatory cytokines in patients with various kinds of acne treated with isotretinoin. | acne vulgaris is the most frequently diagnosed dermatosis in patients aged between 11 and 30. it is believed that it affects about 80% of persons in this age group or even, taking into account lesions of low intensity, 100% of young people. the role of cytokines in the pathogenesis of acne is not fully known. the tlr2 receptors play a role in the aetiology of acne. stimulation of tlr2 by propionibacterium acnes makes the il-8 and il-12 concentrations increase. | 2014 | 24683393 |
| propionic acid and its esterified derivative suppress the growth of methicillin-resistant staphylococcus aureus usa300. | previously, we demonstrated that propionibacterium acnes, a human skin commensal bacterium, ferments glycerol into short-chain fatty acids, including propionic acid. propionic acid suppressed the growth of staphylococcus aureus usa300, a community-acquired methicillin-resistant bacterium, in vitro and in vivo. in this study, it is demonstrated that the anti-usa300 activity of propionic acid persisted after buffering the acid with 4-(2-hydroxyethyl)-1- piperazineethanesulfonic acid. this suggests ... | 2014 | 24686580 |
| antimicrobial and anti-inflammatory properties of nostocionone isolated from nostoc commune vauch and its derivatives against propionibacterium acnes. | propionibacterium acnes is the primary pathogenic agent responsible for acne vulgaris on the skin and hair follicles. overgrowth of this bacterium inhibits growth and promotes follicular inflammation, with an associated increase in pro-inflammatory cytokine production. p. acnes has therefore been considered the main target for the prevention and medical treatment of acne vulgaris. the aim of this study was to evaluate the in vitro anti-p. acnes and anti-inflammatory properties of 6 compounds iso ... | 2014 | 24699048 |
| inflammation and acne: putting the pieces together. | acne vulgaris is a common skin disease in which abnormal desquamation, excess sebum production, proliferation of propionibacterium acnes, and production of proinflammatory mediators all contribute to the pathogenesis of the disease. a review of the literature shows that our current understanding of acne pathogenesis continues to evolve. recent data suggests that inflammatory mediators may play a more important role than previously realized; however, how these mediators work independently as well ... | 2014 | 24719066 |
| antibiotic stewardship in dermatology: limiting antibiotic use in acne. | widespread use of antibiotics in all areas of medicine has led to significant problems with antimicrobial resistance, which have begun to compromise the usefulness of antibiotics. antibiotics have long been a keystone of acne therapy. there is a large population of patients with acne and antibiotic therapy is often used for long durations; thus, acne therapy results in extensive antibiotic exposure. this article discusses the role of antibiotic therapy in acne from the perspective of how clinici ... | 2014 | 24721547 |
| poor utility of serum interleukin-6 levels to predict indolent periprosthetic shoulder infections. | infection after shoulder arthroplasty can present a diagnostic challenge. the purpose of this study was to evaluate the utility of serum interleukin-6 (il-6) levels in diagnosis of periprosthetic infection in patients undergoing revision shoulder arthroplasty. | 2014 | 24725902 |
| lower complication rates for cranioplasty with peri-operative bundle. | the overall benefits of craniectomy must include procedural risks from cranioplasty. cranioplasty carries a high risk of surgical site infections (ssi) particularly with antibiotic resistant bacteria. the goal of this study was to measure the effect of a cranioplasty bundle on peri-operative complications. | 2014 | 24731574 |
| vaccination of lambs against haemonchus contortus infection with a somatic protein (hc23) from adult helminths. | a somatic protein from adult haemonchus contortus (hc23), the most abundant component in a low molecular weight fraction with known immunizing effect against experimental haemonchosis, has been purified by immunochromatography. the immunoprophylactic value of hc23 was tested in groups of 5-6 months old assaf lambs using al(oh)(3) or escherichia coli lipopolysaccharide+inactivated propionibacterium acnes as adjuvant and the results compared with uninfected control, uninfected and challenged or in ... | 2014 | 24759430 |
| constrictive infectious pericarditis caused by propionibacterium acnes. | 2013 | 24775828 |