Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| in vitro studies of tigemonam: a comparison of the minimum inhibitory and minimum bactericidal concentrations (mic vs mbc). | the in vitro activity of tigemonam, a new oral monobactam, was studied with special attention to minimum inhibitory concentrations (mics) and minimum bactericidal concentrations (mbcs). against 250 clinical isolates, it inhibited 100% of escherichia sp., klebsiella sp., serratia sp., citrobacter sp., providencia sp., proteus sp., morganella sp., aeromonas sp., yersinia sp., shigella sp., and haemophilus sp. at 0.5 mg/l or less. with 1 mg/l, 75% of enterobacter sp. were inhibited; however, three ... | 1989 | 2809701 |
| modifications of dna-gyrase and of permeability in a norfloxacin-resistant clinical isolate of providencia stuartii. | we obtained a clinical isolate of providencia stuartii showing a high level of resistance to norfloxacin and to other 4-quinolones, whose target is the enzyme dna-gyrase. this strain showed resistance also to beta-lactam and aminoglycoside antibiotics. in order to detect modification of dna-gyrase, we performed supercoiling assays in vitro in presence of norfloxacin and ciprofloxacin. furthermore, outer membrane proteins, which are involved in permeability mechanisms, were analyzed on sds-polyac ... | 1987 | 2826973 |
| purification, characterization, and genetic organization of recombinant providencia stuartii urease expressed by escherichia coli. | recombinant urease from providencia stuartii has been expressed in and purified from escherichia coli, and the genetic organization of the structural genes has been determined. urease expression was induced by urea and repressed by nitrogen-rich components in the medium. the urease protein was purified 331-fold by deae-sepharose, phenyl-sepharose, mono-q, and phenyl-superose chromatographies with a 7.3% yield. the enzyme possessed a km for urea of 9.3 mm and hydrolyzed urea at a vmax of 7,100 mu ... | 1988 | 2834333 |
| norfloxacin resistance in providencia stuartii: modifications in dna-gyrase and permeability. | 1988 | 2837244 | |
| effect of aminoglycoside concentration on reaction rates of aminoglycoside-modifying enzymes. | reaction rates of several reference aminoglycoside-modifying enzymes were studied at various substrate concentrations. the resulting concentration-response curves showed wide variation in threshold concentration, in curve slope, in enzyme saturation, and in substrate inhibition. together, the curves of a defined aminoglycoside panel yielded more specific information for each individual aminoglycoside-modifying enzyme tested than did conventional substrate profiles obtained at a single substrate ... | 1988 | 2840015 |
| proteus mirabilis urease: genetic organization, regulation, and expression of structural genes. | proteus mirabilis, a cause of serious urinary tract infection, produces urease, an important virulence factor for this species. the enzyme hydrolyzes urea to co2 and nh3, which initiates struvite or apatite stone formation. genes encoding urease were localized on a p. mirabilis chromosomal dna gene bank clone in escherichia coli by deletion analysis, subcloning, bal31 nuclease digestion, transposon tn5 mutagenesis, and in vitro transcription-translation. a region of dna between 4.0 and 5.4 kilob ... | 1988 | 2841283 |
| enzymatic degradation of urinary indoxyl sulfate by providencia stuartii and klebsiella pneumoniae causes the purple urine bag syndrome. | the etiology of the purple urine bag syndrome (pubs), in which the urinary catheter bag of some elderly patients develops intense purple coloration, was studied. the purple was found to be a mixture of indirubin dissolved in the plastic and indigo on its surface. six patients with pubs were studied, and providencia stuartii was isolated from the urine of five and klebsiella pneumoniae was isolated from the urine of one. these strains produced indigo in 7.9 mm indoxyl sulfate-containing agar. one ... | 1988 | 2846640 |
| providencia stuartii: a search for its natural habitat. | a selective differential medium has been used to search for providencia stuartii in sewage, sewage contaminated natural waters and the faeces and skin of a small population of healthy non-hospitalized males. colonization of 12 male patients with long-term indwelling bladder catheters and the general environment of the spinal injury unit was also examined. providencia stuartii was not isolated from the non-hospital samples, but colonization of the urine (two patients) faeces (five patients) and s ... | 1985 | 2862199 |
| an investigation into in vitro methods for the detection of chlorhexidine resistance. | during an outbreak of catheter-related urinary tract infection, due to proteus mirabilis, it was suggested that the epidemic strain was resistant to chlorhexidine. in this study, the minimum inhibitory concentrations (mics) of chlorhexidine to the epidemic pr. mirabilis and other laboratory isolates were tested in different media. results were compared with killing times using 1/4 strength ringers solution, normal human urine and the in vivo killing times in two patients' catheter bags. it was f ... | 1985 | 2868036 |
| bacteriophage d: an incd group plasmid-specific phage. | the existence of the plasmid incompatibility group d was reaffirmed as a result of compatibility experiments done on plasmids r687, r711b, r778b and r840 which were previously tentatively accepted as constituting the group. the group was further delineated by the isolation of a phage, phage d, which adsorbed specifically to incd plasmid-encoded pili produced by escherichia coli k12 strains and strains of salmonella typhimurium, proteus morganii and klebsiella oxytoca harbouring one of these plas ... | 1985 | 2870129 |
| survey of multiply resistant providencia stuartii in a chronic care unit. | providencia stuartii was cultured over a 4-year period from the urinary tract, throat, perineum, axilla and stools of patients in a long-term chronic care unit, the most common site of colonization being the urinary tract. a total of 17 patients had prov. stuartii bacteraemia and manipulation of the urinary tract preceded bacteraemia in 10 cases. eighty-two per cent of the patients had long-term urinary tract colonization from 1 month to 4 years. although most isolates were resistant to all amin ... | 1987 | 2883227 |
| the resistance of urinary tract pathogens to chlorhexidine bladder washouts. | isolates of providencia stuartii, pseudomonas aeruginosa, proteus mirabilis, klebsiella pneumoniae and streptococcus faecalis from urinary-tract infections in spinally-injured patients together with escherichia coli 10418 were challenged with chlorhexidine (200 mg l-1) in a model of a catheterized bladder under conditions which simulate the bladder washout technique. all species survived the antiseptic. organisms growing on the wall of the bladder model appeared to be particularly resistant and ... | 1987 | 2888808 |
| mr/k hemagglutination of providencia stuartii correlates with adherence to catheters and with persistence in catheter-associated bacteriuria. | providencia stuartii was the most prevalent bacterial species isolated, for one year, from weekly urine specimens from 51 long-term catheterized patients. significantly more strains causing bacteriuric episodes of long duration expressed mr/k (mannose-resistant/klebsiella-like) hemagglutination (74%) than did those causing episodes of short duration (26%; p = .004). isolates expressing mr/k hemagglutinin bound in higher numbers to catheter material (p = .023) than did those not expressing this h ... | 1988 | 2891774 |
| detection of genomic variation in providencia stuartii clinical isolates by analysis of dna restriction fragment length polymorphisms containing rrna cistrons. | chromosomal dna from 26 strains of providencia stuartii isolated mainly in hospitals in the united kingdom and reference strains of p. stuartii, p. rustigianii, and proteus vulgaris were digested with the restriction endonucleases ecori and hindiii. after electrophoresis in agarose gels, the fragments were subjected to southern blot hybridization analysis with a biotin-labeled cdna probe transcribed from a mixture of 16s and 23s rrna from p. stuartii nctc 11800t. the pattern of bands (the rdna f ... | 1988 | 2903175 |
| effect of ciprofloxacin on phagocytosis. | certain aspects of the relationship between host defence mechanisms and the new quinoline derivative ciprofloxacin in comparison to norfloxacin and ofloxacin were studied. ciprofloxacin did not affect chemotaxis of human polymorphonuclear leucocytes in agarose. in leucocytes exposed to ciprofloxacin, norfloxacin and ofloxacin neither the chemiluminescent response to opsonized zymosan and formyl-methionyl-leucyl-phenylalanine nor the phagocytic or bactericidal activity was affected. however, kill ... | 1985 | 2936604 |
| inhibition of providencia stuartii cell envelope enzymes by chlorhexidine. | the possibility that chlorhexidine is a specific inhibitor of membrane bound bacterial adenosine triphosphatase (atpase) was addressed. the in-vitro susceptibilities of several providencia stuartii cell envelope enzymes, including atpase, to chlorhexidine were compared. the following concentrations of chlorhexidine were required to cause 50% inhibition of enzyme activity in preparations from chlorhexidine-sensitive strains (mic 50 mg chlorhexidine/l): atpase (160 mg/l), succinic dehydrogenase (g ... | 1987 | 2956230 |
| further differentiation of enterobacteriaceae by means of siderophore-pattern analysis. | by means of a combination of 5 siderophore bioassays using several indicator strains, genera, species and subspecies of enterobacteriaceae can be further differentiated. enterobactin, aerobactin and other siderophores produced can be detected. each strain shows specific pattern which we called siderophore-pattern. it is easy to separate morganella, proteus, providencia, yersinia strains from the genera salmonella, shigella, escherichia coli, enterobacter, citrobacter, klebsiella, serratia. enter ... | 1988 | 2970195 |
| evolution of an r plasmid from a cryptic plasmid by transposition of two copies of tn1 in providencia stuartii. | examination of a series of isolates of providencia stuartii collected over an 18 month period from a chronic-care patient at bristol royal infirmary revealed the emergence of resistance to carbenicillin. resistance was mediated by a 47 kb plasmid which transferred by conjugation to a plasmid-free strain of p. stuartii but not to escherichia coli. carbenicillin-sensitive isolates were either plasmid-free or contained a 36 kb cryptic plasmid. restriction endonuclease mapping of this plasmid showed ... | 1985 | 2985741 |
| effect of an activated sludge wastewater treatment plant on ambient air densities of aerosols containing bacteria and viruses. | bacteria- and virus-containing aerosols were studied during the late summer and fall seasons in a midwestern suburb of the united states before and during the start-up and operation of an unenclosed activated sludge wastewater treatment plant. the study showed that the air in this suburban area contained low-level densities of indicator microorganisms. after the plant began operating, the densities of total aerobic bacteria-containing particles, standard plate count bacteria, total coliforms, fe ... | 1985 | 2988442 |
| comparative activities of the beta-lactamase inhibitors ytr 830, clavulanate and sulbactam combined with extended-spectrum penicillins against ticarcillin-resistant enterobacteriaceae and pseudomonads. | the in-vitro synergistic activity of ytr 830, a new beta-lactamase inhibitor, combined with four extended-spectrum penicillins (ticarcillin, piperacillin, mezlocillin and apalcillin) against ticarcillin-resistant clinical isolates of gram-negative enteric bacilli was compared with that of clavulanate and sulbactam. synergy testing was performed with fixed concentrations of beta-lactamase inhibitors (8 mg/l) combined with doubling dilutions of beta-lactams in microdilution trays. synergy was defi ... | 1986 | 3019984 |
| induction/inhibition of chromosomal beta-lactamases by beta-lactamase inhibitors. | many species of gram-negative bacteria produce chromosomal beta-lactamases that can be induced to high-level expression by exposure to beta-lactam antibiotics. fifty-four strains of escherichia coli, enterobacter, proteus, citrobacter, and morganella were examined for beta-lactamase inducibility by clavulanic acid, sulbactam, ytr 830, ampicillin, and cefoxitin. cefoxitin proved to be the most potent inducer, affecting most of the strains of enterobacter and morganella. clavulanic acid induced 30 ... | 1986 | 3026004 |
| identification of porins in outer membrane of proteus, morganella, and providencia spp. and their role in outer membrane permeation of beta-lactams. | proteus mirabilis, proteus vulgaris, morganella morganii, providencia rettgeri, and providencia alcalifaciens, which were once classified into the same genus, proteus, were studied. cefoxitin-resistant mutants from these species were isolated, and it was confirmed that the resistance was attributed to the lack of an outer membrane protein, resulting in a significant decrease in the penetration of hydrophilic cephalosporins through the outer membrane. comparison of the mutant strains with their p ... | 1987 | 3034144 |
| clinical correlates of bacteremia in a veterans administration extended care facility. | little is known about bacteremia in long-term care facilities. we have conducted a retrospective study during a 12-month period analyzing the clinical correlates of bacteremia in 533 chronically institutionalized, predominantly male patients, with an average age of 69 years. thirty-four men had forty-two bacteremic illnesses during this period. the incidence rate was 0.30 episodes per 1000 patient care days, and the mortality rate was 21%. the urinary tract was the most frequently identified tis ... | 1988 | 3042843 |
| [in vitro bactericidal effect of cefotetan-aminoside combinations]. | bactericidal activity of cefotetan-gentamicin combinations was studied on 6 bacterial strains: s. aureus, k. pneumoniae, e. cloacae, s. marcescens, p. vulgaris, p. stuarti. time kille curves technic was performed with final concentrations of cefotetan: 4 at 32 mg/l, and of gentamicin: 0.25; 0.5; 1; 2; 8 mg/l and with an 10(6) cfu/ml inoculum. cefotetan at 4 mg/l was not able to obtain a 0.01% (percentage of survivors) bactericidal activity before 24 h. the combination cefotetan-gentamicin (0.25 ... | 1988 | 3043329 |
| [in vitro antibacterial activity of apalcillin on aerobic bacteria and the regression curve]. | minimal inhibitory concentrations (mics) of apalcillin (apl) were evaluated by agar dilution on 1,201 bacterial strains isolated simultaneously in four university hospitals; agar diffusion tests (disks apl: 75 micrograms) were performed on these strains to establish relationship between mic and zone diameters. for enterobacteriaceae naturally non beta-lactamase-producing (e. coli and p. mirabilis), mode mic was 0.5 microgram/ml; some acquired penicillinase-producing strains were only inhibited b ... | 1988 | 3054743 |
| [evolution of bacterial resistance to five aminoglycosides. a study of 3,354 strains isolated in a hospital milieu]. | the authors studied the susceptibility to 5 aminoglycosides (amikacin, dibekacin, gentamicin, netilmicin and tobramycin) of 3,354 strains isolated at the centre hospitalier sud in bordeaux during 1987. the results are compared to those obtained in 1984 on 2,818 strains. amikacin remains the most active aminoside against the enterobacteriaceae and acinetobacter; against pseudomonas, tobramycin has become the best one at that time, as well as netilmicin against staphylococcus aureus. evolution: no ... | 1988 | 3054744 |
| inducible beta-lactamases: clinical and epidemiologic implications for use of newer cephalosporins. | the emergence of resistance to multiple beta-lactam antibiotics is a major problem in patients infected with organisms that characteristically produce inducible beta-lactamases--e.g., species of pseudomonas, enterobacter, serratia, citrobacter, indole-positive proteus, and providencia. resistance has emerged in 14%-56% of patients infected with these organisms and treated with one of the newer cephalosporins. the emergence of resistance has been associated with clinical failure or relapse in 25% ... | 1988 | 3055176 |
| providencia stuartii: a common cause of antibiotic-resistant bacteriuria in patients with long-term indwelling catheters. | the long-term-catheterized urinary tract may offer a particular niche to providencia stuartii, which is otherwise an uncommon clinical isolate. published accounts of bacteriuria in patients catheterized for long periods indicate that p. stuartii has often been found as frequently as familiar uropathogens such as escherichia coli, proteus mirabilis, enterococcus, and pseudomonas aeruginosa. as in most nosocomial infections, the frequency of isolation of a given species has commonly differed among ... | 1986 | 3081988 |
| distribution of bacteria and yeasts within the 10-ml isolator during the processing of seeded blood samples. | forty-five organisms consisting of stock cultures and clinical isolates of bacteria and yeast were separately inoculated into outdated blood bank blood to achieve a concentration of approximately 100 cfu/ml. blood with each organism was introduced into groups of four isolators (e. i. du pont de nemours & co., inc., wilmington, del.), which were then processed according to the isostat instructions of the manufacturer. the supernatant, sediment, and wash (material removed from the surface of the s ... | 1986 | 3084546 |
| [antibacterial activity of (+)-negamycin prepared by a new method]. | antibacterial activity of (+)-negamycin (ngm) prepared by a new method was investigated for some bacteria. the results demonstrated that this antibacterial activity of synthesized ngm was almost the same as compared to that of naturally obtained ngm, and was also effective to pseudomonas aeruginosa harboring multiple drug resistant plasmid kr102. | 1986 | 3084829 |
| in vitro evaluation of a-56619 (difloxacin) and a-56620: new aryl-fluoroquinolones. | the in vitro antibacterial potencies of a-56619 and a-56620, two new aryl-fluoroquinolones, were compared with the potency of norfloxacin against a broad spectrum of organisms. cefotaxime, aztreonam, piperacillin, imipenem, penicillin, and gentamicin were also tested for reference purposes. the mics required to inhibit at least 90% of the strains tested ranged from 0.25 to 4 micrograms/ml for a-56619 and from 0.06 to 0.5 microgram/ml for a-56620 for members of the enterobacteriaceae. a-56619 was ... | 1986 | 3087274 |
| survey of aminoglycoside resistance patterns. | we studied the susceptibility of 545 gram-negative clinical isolates to six aminoglycosides: gentamicin, tobramycin, netilmicin, amikacin, 2'-n-ethylnetilmicin, and 6'-n-ethylnetilmicin. the resistant strains (359) have been classified into aminoglycoside resistance (patterns) phenotypes (agrps) corresponding to known resistance mechanisms. the results clearly demonstrated that most strains of proteus spp., klebsiella spp., escherichia coli and pseudomonas aeruginosa appeared to be able to adeny ... | 1986 | 3087636 |
| resistance of providencia stuartii to chlorhexidine: a consideration of the role of the inner membrane. | spheroplasts of three strains of providencia stuartii (one sensitive, one moderately sensitive and one resistant to chlorhexidine) were induced by cefoxitin, glycine or a lysozyme-tris-edta combination, and their susceptibility to chlorhexidine-induced lysis investigated. maximum lysis of spheroplasts occurred at a low (2.5-5 micrograms/ml) concentration of chlorhexidine and was greatest with the most sensitive strain, pv2. the possible role of the inner membrane in chlorhexidine resistance is c ... | 1986 | 3087933 |
| in vitro activity of aztreonam against gram negative bacteria from clinical specimens and its comparison with other commonly used antibiotics. | a total of 755 gram negative bacteria isolated from clinical specimens were tested against aztreonam by the disc agar diffusion test. the strains of bacteria used in this study consisted of escherichia coli (314), enterobacter aerogenes (30), e. agglomerans (7), e. cloacae, (39), citrobacter diversus (9), c. freundii (13), hafnia alvei (3), acinetobacter calcoaceticus (10), klebsiella oxytoca (6), k. ozaenae (5), k. pneumoniae (107), morganella morganii (3), moraxella sp. (10), pasteurella multo ... | 1986 | 3088346 |
| aminoglycosides plus beta-lactams against gram-negative organisms. evaluation of in vitro synergy and chemical interactions. | combination antibiotic therapy has been used mainly to broaden the antibacterial spectrum and prevent the development of resistance. antibiotic combinations proven to be synergistic in vitro are associated with a significantly better in vivo response, particularly in the compromised host in whom traditional treatment combines an antipseudomonal penicillin plus an aminoglycoside. several investigators have examined combining new agents, such as the third-generation cephalosporins (cefotaxime, cef ... | 1986 | 3088998 |
| review of epidemic aminoglycoside resistance worldwide. | epidemic aminoglycoside resistance may be caused by the spread of a species with distinctive chromosomal genes (e.g., pseudomonas aeruginosa), or it may be due to the dissemination of plasmids or transposons between genera. although strains of p. aeruginosa resistant to aminoglycosides because of impermeability may cause nosocomial outbreaks, most of the acute increases in aminoglycoside resistance are due to the spread of inactivating enzymes by plasmids. the index species for intergeneric outb ... | 1986 | 3089005 |
| comparison of bacteria in the tympanic cavity and the mastoid antrum in chronic otitis media. | materials collected from the tympanic cavity before operation and from the mastoid antrum during operation of 58 discharging ears of patients with chronic otitis media were cultured, and the bacteria in these two cavities were compared. staphylococcus aureus was the commonest organism in the tympanic cavity, and s epidermidis in the mastoid antrum. anaerobic bacteria were found only in the mastoid antrum of patient with cholesteatoma. in 32 (55 per cent) of the 58 ears examined, bacteria were de ... | 1986 | 3092687 |
| do clinical microbiology laboratories report complete bacteriology in urine from patients with long-term urinary catheters? | bacteriuria associated with long-term urinary catheters (those in place for greater than or equal to 30 days) appears to be the most common nosocomial infection in u.s. medical care facilities. this bacteriuria is polymicrobial and dynamic and accompanied by fevers, catheter obstructions, bacteremias, and deaths. we compared the reporting by our research laboratory of bacteria present in urine from long-term-catheterized nursing home patients with that by two commercial laboratories. the commerc ... | 1986 | 3093528 |
| [in-vitro activity of cefonicid on hospital bacteria. regression line and proposal for critical values]. | antimicrobial activity of cefonicid, a new second generation cephalosporin, against 315 hospital isolates (4th trimester 1984) was investigated. e. coli and proteus mirabilis were the most susceptible species. all e. coli strains except one were inhibited at 8 mg/l (modal mic: 0.5); mics of all indole + proteus were 8 mg/l (modal mic: 0.06). another group was moderately susceptible: mics of klebsiella and citrobacter ranged from 0.12 to 128 mg/l, but mics of 50% of these strains were less than o ... | 1986 | 3095773 |
| [a clinical bacteriological efficacy study on a fosfomycin otic solution]. | fosfomycin (fom) otic solution was administered to 587 patients with suppurative otitis media infections including 190 patients in the dose-establishment test, 126 patients in the open clinical trial and 271 patients in the double blind test. various bacteria were detected in the 549 cases in which bacteriological investigation was possible. main bacteria detected from the above cases were s. aureus (261 strains, 47.5%), p. aeruginosa (93 strains, 16.9%), coagulase negative staphylococci (cns) ( ... | 1986 | 3099028 |
| reversal of the surface effects of chlorhexidine diacetate on cells of providencia stuartii. | chlorhexidine diacetate (cha) increased the hydrophobicity of the cell surface of cells of three strains of providencia stuartii. removal of at least some of the cha from the cells by washing them with an appropriate antidote partially reversed the hydrophobicity-increasing action of the biguanide. the effects of other treatments on cell surface hydrophobicity were examined with these strains and, for comparison, with two strains each of escherichia coli and pseudomonas aeruginosa: ethylenediami ... | 1986 | 3100485 |
| antibacterial properties of imipenem with special reference to the activity against methicillin-resistant staphylococci, cefotaxime-resistant enterobacteriaceae and pseudomonas aeruginosa. | imipenem was examined with standardized agar dilution procedures against a wide range of bacteria. geometric mean mics against the genera escherichia, klebsiella, enterobacter, citrobacter and serratia were 0.1-0.4 mg/l, and proteus and providencia spp. were inhibited by 0.25-4 mg/l. acinetobacter calcoaceticus var. anitratum strains were inhibited by concentrations ranging from 0.12-0.5 mg/l. methicillin-susceptible staphylococci were highly susceptible to the drug (mics: less than or equal to ... | 1986 | 3102452 |
| nosocomial infectious balanoposthitis in neutropenic patients. | we have reported balanoposthitis as a source of fever and bacteremia in two neutropenic uncircumcised patients. the etiologic organisms were pseudomonas aeruginosa in one case and providencia stuartii in the other. in one patient, the diagnosis was delayed by the presence of a condom catheter. this emphasizes the importance of personal hygiene in uncircumcised men about to undergo immunosuppressive therapy, and the need for judicious use of condom catheters in such patients. | 1987 | 3110971 |
| [study of the sensitivity to pipemidic acid, pefloxacin and norfloxacin of 444 bacterial strains isolated at a general hospital]. | after one year of use of pefloxacin in the intensive care unit, medicine unit and surgery unit and the following recent commercialization without prescription of norfloxacin, we studied for a period of two months (april and may 1986) the susceptibility to pipemidic acid, to pefloxacin and norfloxacin of 444 bacteria strains isolated obtained from clinical specimens. the antibiotic susceptibility is determined by disk diffusion test. we obtained the following results: susceptible methicillin stap ... | 1987 | 3112705 |
| disk diffusion susceptibility testing and broth microdilution quality control guidelines for bmy-28100, a new orally administered cephalosporin. | the bmy-28100 30-micrograms-disk test was evaluated by using 615 clinical isolates. regression analyses and error rates were determined, leading to the recommendation of greater than or equal to 18-mm zone diameters (mic correlate, greater than or equal to 8.0 micrograms/ml) for susceptibility and less than or equal to 14-mm zone diameters (mic correlate, greater than or equal to 32 micrograms/ml) for resistance. nearly all false-susceptible disk test results were among the providencia spp. and ... | 1987 | 3121667 |
| assessment of antiseptic bladder washout procedures using a physical model of the catheterised bladder. | a simple physical model of the catheterised bladder has been used to assess the activities of antiseptic agents that have been recommended as bladder instillations in the treatment of urinary tract infections in patients with indwelling catheters. the activities of povidone-iodine, phenoxyethanol, chlorhexidine, chlorhexidine supplemented with edta + tris, noxythiolin and neomycin were examined against selected species of uropathogens. except for phenoxyethanol against pv. stuartii and possibly ... | 1987 | 3122868 |
| enoxacin: in-vitro and animal evaluation as a parenteral and oral agent against hospital bacterial isolates. | enoxacin was evaluated in in-vitro tests and in studies of effectiveness and blood concentrations in the mouse. enoxacin was active against both susceptible and multiresistant hospital isolates of enterobacteriaceae, pseudomonas aeruginosa, haemophilus influenzae, neisseria gonorrhoeae and staphylococci. less susceptible were streptococci and anaerobes. of nine quinolones tested, only norfloxacin was equivalent in vitro. the mbcs of enoxacin were one- to twofold greater than the mics, and enoxac ... | 1988 | 3129392 |
| comparative in vitro activity of the new oral cephalosporin cefixime. | cefixime was 8 to 10 times more active than cefaclor and augmentin against isolates of escherichia coli, klebsiella pneumoniae and salmonella typhi, mic90 values ranging from 0.06 to 0.25 micrograms/ml. however, none of these three drugs was particularly active against isolates of more resistant gram-negative bacilli such as enterobacter, serratia, citrobacter, acinetobacter, providencia and achromobacter spp. the lowest mic values for gram-negative bacilli were seen with ciprofloxacin, except f ... | 1988 | 3137053 |
| mechanism of inhibition of chromosomal beta-lactamases by third-generation cephalosporins. | the kinetic interactions of the beta-lactamase from enterobacter cloacae 908 r with ceftriaxone, cefotaxime, and ceftazidime have been examined in detail. with all of these cephalosporins, there is an initial rapid reaction involving opening of the beta-lactam that then decreases to a slower steady-state rate (kss) of beta-lactam hydrolysis (at 37 degrees c: ceftriaxone, kss = 0.044 s-1; cefotaxime, kss = 0.033 s-1; ceftazidime, kss = 0.011 s-1). more than stoichiometric quantities of beta-lacta ... | 1988 | 3142012 |
| in-vitro activity of pefloxacin compared to enoxacin, norfloxacin, gentamicin and new beta-lactams. | the in-vitro activity of pefloxacin was compared with that of norfloxacin, enoxacin, nalidixic acid, gentamicin, cefotaxime, ceftazidime and, where appropriate, other beta-lactams against a total of 363 recent clinical isolates. an agar dilution procedure was used to determine mics and two inocula (10(4) and 10(6) cfu) were used throughout. pefloxacin inhibited 90% of isolates of escherichia coli, klebsiella pneumoniae, proteus mirabilis, indole-positive proteus spp., enterobacter spp., shigella ... | 1985 | 3156112 |
| in vitro activity of lomefloxacin (sc-47111; ny-198), a difluoroquinolone 3-carboxylic acid, compared with those of other quinolones. | lomefloxacin (sc-47111; ny-198) is a new difluoroquinolone agent. it inhibited 90% of escherichia coli, klebsiella spp., enterobacter spp., citrobacter spp., proteus mirabilis, morganella morganii, proteus vulgaris, serratia marcescens, salmonella spp., shigella spp., aeromonas spp., yersinia spp., haemophilus influenzae, and neisseria gonorrhoeae at less than or equal to 2 micrograms/ml. lomefloxacin inhibited 90% of pseudomonas aeruginosa at 4 micrograms/ml. lomefloxacin was equal in activity ... | 1988 | 3164987 |
| in-vitro and in-vivo activities of t-3262, a new pyridone carboxylic acid. | t-3262[p-toluenesulfonic acid salt of dl-7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1, 4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid monohydrate] is a new pyridone carboxylic acid with a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria. the activity of t-3262 against most enterobacteriaceae was comparable with that of ciprofloxacin except proteus spp. and providencia rettgeri and exceeded that of ofloxacin and norfloxacin. the activ ... | 1988 | 3182417 |
| [evaluation on the capability of indole pyruvic acid production by members of proteeae on different brands of sulfide-indole-motility]. | members of proteeae were vertically inoculated into different brands of sulfide-indole-motility (sim) medium for evaluating the capability of ipa production. a total of 328 clinical strains of tribe proteeae was used as tested organisms, including 186 proteus mirabilis strains, 62 morganella morganii strains, 31 proteus vulgaris strains, 27 providencia rettgeri strains, 14 providencia stuartii and 8 providencia alcalifaciens strains. seven different brands of sim medium used in this study are ky ... | 1988 | 3197461 |
| in vitro activities of a-56619 (difloxacin) and a-56620, two aryl fluoroquinolones. | the in vitro activities of a56619 (difloxacin) and a-56620, two newer quinolones, have been compared with the activities of ciprofloxacin, ofloxacin, ceftazidime and netilmicin. a total of 782 clinical, bacterial isolates were employed. minimal inhibitory concentrations (mics) were determined under standard conditions with all isolates and, for 100 isolates against difloxacin and a-56620, with variation of agar ph and bacterial inoculum size. on a weight-for-weight basis, ciprofloxacin and a-566 ... | 1988 | 3208547 |
| [antibacterial activities of monobactams against fresh clinical isolates]. | antibacterial activities of monobactam antibiotics (carumonam (crmn) and aztreonam (azt] against gram-negative bacilli isolated from inpatients in the latter half of 1987 were investigated using penicillin (pc: piperacillin (pipc], cephems (ceps: ceftazidime (caz), cefotaxime (ctx), latamoxef (lmox), cefsulodin (cfs], carbapenem (imipenem (ipm] and pyridonecarboxylic acids (norfloxacin (nflx) and ofloxacin (oflx] as reference antibiotics. a total of 400 strains of 13 species, i.e. escherichia co ... | 1988 | 3210297 |
| [antibacterial activity of gentamicin against clinical isolates in pediatrics]. | antibacterial activity of gentamicin (gm), along with activities of other aminoglycosides and beta-lactams, was studied against clinical isolates collected from pediatric patients during a period of may 1986-april 1987. 1. gm-resistance was noted in 22% of staphylococcus aureus, 6% of proteus vulgaris, 8% of morganella morganii, 40% of providencia spp., 6% of enterobacter spp., 14% of serratia marcescens, and 14% of pseudomonas aeruginosa isolates. no gm-resistance was observed with isolates of ... | 1988 | 3216475 |
| in vitro activity of cefixime, a new oral cephalosporin. | the in vitro activities of cefixime and seven comparative oral antimicrobials were studied. mic90s of cefixime were 0.015-1 micrograms/ml for haemophilus influenzae, branhamella catarrhalis, escherichia coli, klebsiella, citrobacter diversus, proteus, providencia, aeromonas hydrophila and streptococcus. mic90s for other enterobacteriaceae were greater than or equal to 2 micrograms/ml; 44% of those strains were inhibited by less than or equal 1 microgram/ml. staphylococcus, psuedomonas aeruginosa ... | 1988 | 3219746 |
| in vitro activity of pefloxacin compared with five other quinolones on nalidixic acid-resistant proteae species. | the in vitro activity of pefloxacin, a new fluoroquinolone, was compared with that of 5 other quinolone compounds (nalidixic and pipemidic acids, norfloxacin, ciprofloxacin, and ofloxacin) against 416 strains of proteae spp. isolated from urine specimens of hospitalized patients with acute urinary tract infections (uti). ciprofloxacin was the most active agent. norfloxacin, ofloxacin, and pefloxacin were similarly active against proteus strains (mic90 = 0.39 microgram/ml). against providencia sp ... | 1988 | 3224396 |
| effect of pefloxacin on adherence of proteus-providencia spp to squamous epithelial cells. | pefloxacin, a new piperazinyl substituted quinolone derivative, reduced at sub-mics (minimal subinhibitory concentrations: four times lower than minimal inhibitory concentrations) the in vitro adherence of proteus-providencia spp. to squamous epithelial cells obtained from the urinary tract. the decrease of adherence was about 30% and 50% after 1 h and, respectively, 16-18 h of incubation with pefloxacin. this finding suggests that pefloxacin may play a role in determining the in vivo adhesion o ... | 1988 | 3224397 |
| isolation of multiple antibiotic resistant enterobacteriaceae from river water. | water samples from the monocacy river in frederick county, maryland, yielded twenty-four isolates which were resistant to tetracycline (ter, 25 micrograms/ml). although these organisms were not initially cultured on a coliform-selective medium, twenty-two of the isolates were gram-negative and carriers of antibiotic resistance to five or more antibiotics; erythromycin, methicillin, novobiocin, penicillin and tetracycline. of the isolates 45% were biochemically identified as providencia stuartii; ... | 1988 | 3241574 |
| activity of cefixime (fk 027) for resistant gram-negative bacilli. | cefixime is an orally absorbable cephalosporin with an extended spectrum of in vitro activity for gram-negative bacteria especially members of the enterobacteriaceae. gram-negative rod isolates collected over a three month period were tested against cefixime. greater than 99% of escherichia coli isolates was susceptible to cefixime including those resistant to ampicillin. similarly isolates of klebsiella, proteus and providencia were also exquisitely susceptible to cefixime as were 91% of entero ... | 1988 | 3243091 |
| resistance of bacterial pathogens to four aminoglycosides and six other antibacterials and prevalence of aminoglycoside modifying enzymes, in 20 uk centres. | a total of 5116 non-fastidious bacterial strains isolated from either blood or urine culture were collected from 20 geographically distributed centres within the uk. upon receipt the strains were identified and the minimum inhibitory concentrations of ten antimicrobial agents in hospital usage were determined for each of the strains. all laboratories submitted a similar range of bacterial species and in species normally considered as sensitive the overall rates of resistance to the different ant ... | 1988 | 3243733 |
| an evaluation of allozyme amino acid substitutions for the study of molecular relationships in providencia strains. | through analysis of molecular relationships in terms of amino acid substitutions, intra- and interspecies differentiations in providencia alcalifaciens, p. stuartii and p. rustigianii were evaluated among the electrophoretic variants of three enzymes, l-malate dehydrogenase, acid phosphatase and esterase-beta a, chosen for their distinct pattern of polymorphism. for each enzyme, molecular relatedness among variants defined by two-dimensional electrophoretic profiles was examined through protein ... | 1988 | 3252906 |
| disk diffusion susceptibility testing for ly163892 (kt-3777), a new orally administered 1-carbacephem. | ly163892, a new orally administered 1-carbacephem, was found to have a spectrum of antimicrobial activity very similar to that of cefaclor. diffusion tests with 30-micrograms ly163892 disks produced acceptable interpretive error rates with greater than or equal to 22 mm as the susceptibility zone diameter. this was required to reduce potential false-susceptibility results, particularly among enterobacter spp. and providencia stuartii: both species included strains that produce beta-lactamases ca ... | 1988 | 3259247 |
| in vitro activity of an oral iminomethoxy aminothiazolyl cephalosporin, r-3746. | the in vitro activity of r-3746, an iminomethoxy aminothiazolyl cephalosporin with a ch2och3 moiety at position 3, was compared with those of other antibiotics. r-3746 inhibited the majority of hemolytic streptococci (groups a, b, c, f, and g) and streptococcus pneumoniae at less than 0.06 micrograms/ml, which was comparable to the activity of amoxicillin, 2- to 8-fold more active than cefixime, and 16- to 64-fold more active than cefaclor and cephalexin. ninety percent of beta-lactamase-produci ... | 1988 | 3260766 |
| the effects of clavulanic acid and sulbactam on beta-lactamase biosynthesis. | clavulanic acid and sulbactam were tested as inducers of beta-lactamase in 21 strains of gram-negative bacteria. beta-lactamase synthesis was inducible in all these strains, as demonstrated by the increased enzyme activities obtained when cells were grown in the presence of 10 mg/l of cefoxitin, the increase varying from 11- to 734-fold however, at the same concentration, neither inhibitor induced significant amounts of beta-lactamase, except in one strain of providencia rettgeri, where both wer ... | 1988 | 3263350 |
| in-vitro activity and beta-lactamase stability of ly163892. | ly163892 is a new orally absorbed carbacephem. it inhibited streptococcus pyogenes and str. pneumoniae at less than or equal to 1 mg/l, but was less active against group b streptococci and groups c, f, g and bovis streptococci with mics of 1 to 2 mg/l for most but as high as 8 mg/l for some isolates. mic90 of methicillin-susceptible staphylococcus aureus was 8 mg/l, but greater than 128 mg/l for methicillin-resistant staphylococci. ly163892 had activity similar to cefaclor and cephalexin with mi ... | 1988 | 3263352 |
| in vitro and in vivo antibacterial activities of me1207, a new oral cephalosporin. | me1207 (pivaloyloxymethyl ester of me1206) is a new oral cephalosporin. me1206 is (6r,7r)-7-[(z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)- acetamido]-3-[(z)-2-(4-methylthiazol-5-yl)-ethyl]-cephem-4-carboxy lic acid. the susceptibilities of about 1,600 clinical isolates to me1206 were determined by the agar dilution method. me1206 showed a broad spectrum of activity against gram-positive and gram-negative bacteria. me1206 was more active than cefaclor, t-2525, and cefixime against staphylococcus ... | 1988 | 3264132 |
| production and properties of haemolysins from clinical isolates of the proteeae. | a collection of 198 clinical isolates of strains belonging to the tribe proteeae was examined for haemolytic activity on blood agar and in brain heart infusion broth. the strains were of diverse bacteriocin and o-antigenic types and from a wide variety of sources. they included representatives of all species of morganella, proteus and providencia. approximately half of the m. morgani strains were haemolytic on blood agar. this activity was not associated with any particular bacteriocin type. the ... | 1988 | 3275780 |
| a survey of iga protease production among clinical isolates of proteeae. | a collection of 100 strains of proteeae, in which all species within the tribe were represented, was examined for iga protease production. the strains were isolated from various clinical specimens from sick and healthy persons in several countries. iga protease-producing strains were not found amongst species of providencia and morganella but were common in proteus spp. all the strains of p. mirabilis and p. penneri and many of the strains of p. vulgaris examined produced an edta-sensitive prote ... | 1988 | 3275781 |
| rapidec ur, a 2-h miniaturized system for pinpointing uropathogens. | a miniaturized 2-h system (rapidec ur; api system, la balme-les-grottes, montalieu-vercieu, france) that uses nine enzymatic tests for the diagnosis of most uropathogens was challenged with 330 strains. with few exceptions (citrobacter, enterobacter, and providencia spp., morganella morganii, and staphylococci other than staphylococcus saprophyticus), there were distinct patterns that allowed at least a preliminary species diagnosis. | 1988 | 3277991 |
| commercial identification systems often fail to identify providencia stuartii. | we tested 145 clinical isolates in an attempt to evaluate some of the most widely used commercial identification systems in europe in terms of their ability to identify providencia strains. two manual miniaturized systems (api 20e and enterotube ii) and three mechanized-automated systems (cobas-bact, sceptor system, and titertek-enterobac-rapid automated system) were evaluated. providencia alcalifaciens and providencia rettgeri strains were correctly identified by all systems in all cases, and i ... | 1988 | 3277997 |
| tigemonam, an oral monobactam. | tigemonam is an orally administered monobactam. at less than or equal to 1 microgram/ml it inhibited the majority of strains of escherichia coli, klebsiella spp., enterobacter aerogenes, citrobacter diversus, proteus spp., providencia spp., aeromonas hydrophila, salmonella spp., shigella spp., serratia marcescens, and yersinia enterocolitica. at less than or equal to 0.25 microgram/ml it inhibited haemophilus spp., neisseria spp., and branhamella catarrhalis. it did not inhibit pseudomonas spp. ... | 1988 | 3279906 |
| evaluation of the ids rapid ss/u system for rapid identification of urinary microorganisms. | the accuracy of a new rapid identification system for common urinary pathogens was compared with that of conventional methods and of miniaturized 18-24-hour identification panels. the rapid system, rapid ss/u (innovative diagnostic system inc., atlanta, ga) is a non-growth-dependent micro-method that identifies selected gram-negative bacilli, gram-positive cocci, and yeasts in two hours by detection of constitutive enzymes acting on chromogenic substrates. a total of 185 representative clinical ... | 1988 | 3285661 |
| comparative in vitro activity of amoxycillin/clavulanate (augmentin), ceftazidime and ceftriaxone against hospital strains of gram-negative and -positive bacteria. | the in vitro antibacterial activities of amoxycillin/clavulanate (augmentin), ceftazidime and ceftriaxone were compared against 330 gram-negative and gram-positive strains isolated from clinical specimens received at the king abdulaziz university hospital (kauh) in saudi arabia. the antibacterial susceptibility was determinated by stokes method and by the minimal inhibitory concentration (mic) using an agar dilution method. ceftazidime and ceftriaxone were the most active antibiotics, inhibiting ... | 1988 | 3293818 |
| in vitro activity and beta-lactamase stability of a new monobactam, b0-1165. | b0-1165 is a 1-carboxy-1-cyclopropoxyamino,4-fluoromethyl monobactam. it inhibited the majority of escherichia coli, klebsiella pneumoniae, klebsiella oxytoca, citrobacter diversus, aeromonas hydrophila, proteus mirabilis, proteus vulgaris, providencia rettgeri, providencia stuartii, yersinia enterocolitica, haemophilus influenzae, neisseria gonorrhoeae, and salmonella and shigella species at less than or equal to 0.125 microgram/ml. overall, its in vitro activity was similar to that of aztreona ... | 1987 | 3300528 |
| [antibacterial activity of enoxacin in vitro and in urine]. | minimal inhibitory concentrations (mic) of enoxacin (eno) were evaluated by agar dilution, in comparison with mic of nalidixic acid (nal), pipemidic acid (pip), oxolinic acid (oxo), pefloxacin (pef), norfloxacin (nor), ofloxacin (ofl) and ciprofloxacin (cip), for eleven enterobacteriaceae reference strains chosen as a function of sensitivity and level of resistance to nal. in the four strains susceptible to nal, mic of eno (0.06 to 0.25 micrograms/ml) were similar to those for pef and nor, 2 to ... | 1987 | 3302849 |
| in vitro and in vivo antibacterial activities of cs-807, a new oral cephalosporin. | cs-807 is a new oral prodrug of r-3746, a cephalosporin derivative, with potent in vitro and in vivo antibacterial activity against both gram-positive and gram-negative bacteria. the susceptibility of about 1,200 clinical isolates to r-3746 was determined by the agar dilution method. ninety percent or more of pathogens such as staphylococcus aureus, streptococci, escherichia coli, klebsiella pneumoniae, klebsiella oxytoca, indole-positive and indole-negative proteus spp., providencia rettgeri, a ... | 1987 | 3310868 |
| ceforanide. a review of its antibacterial activity, pharmacokinetic properties and clinical efficacy. | ceforanide is a 'second generation' cephalosporin administered intravenously or intramuscularly. it is similar to cefamandole and cefonicid in its in vitro superiority to 'first generation' cephalosporins against several species of enterobacteriaceae as well as its activity against haemophilus influenzae, including beta-lactamase-producing strains. its activity against staphylococcus aureus is less than that of cefamandole, cefuroxime and first generation cephalosporins. the in vitro activity ag ... | 1987 | 3315624 |
| [drug resistance of proteus vulgaris, proteus morganii and providencia rettgeri isolated from diagnostic specimens]. | 1987 | 3324173 | |
| microbiological perspectives of co-trimoxazole. | trimethoprim-sulfamethoxazole in vitro activity was compared with ampicillin, tetracycline, sulfonamide and trimethoprim against isolates of 24 gram-negative and 11 gram-positive species. the incidence of more than 10% of strains with minimal inhibitory concentrations above 32 mg/l was restricted to escherichia coli, shigella spp., klebsiella pneumoniae, providencia rettgeri, morganella morganii, methicillin-resistant staphylococcus aureus and staphylococcus epidermidis. occasionally, streptococ ... | 1987 | 3325434 |
| [the antimicrobial activity of sisomicin against fresh clinical isolates]. | antimicrobial activities of sisomicin (siso) against clinical isolates obtained in the second half of 1986 were investigated together with other 4 aminoglycosides (ags) (gentamicin (gm), tobramycin (tob), dibekacin (dkb), amikacin (amk] and 2 cephems (cefotiam, cefotaxime), and were compared to the results reported in the period of late 1970's through early 1980's in japan. 1. the incidence of siso-resistant staphylococcus aureus in the present study was 18% and is comparable to that of the othe ... | 1987 | 3327965 |
| investigation of a providencia rettgeri strain that has enterobacterial common antigen in the immunogenic state. | antigenic material obtained by phenol-water extraction from providencia rettgeri strains, escherichia coli o:14 strains, and mutants of the e. coli o:14 strain were examined by the passive (indirect) hemagglutination technique, by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and by immune blotting (lipopolysaccharide (lps) blotting). providencia rettgeri 965, like e. coli o:14, was demonstrated to have an enterobacterial common antigen (eca) in the immunogenic form but, unlike e. c ... | 1987 | 3328641 |
| the organization and control of expression of the pst i restriction-modification system. | 1987 | 3333366 | |
| [nosocomial infections of the urinary tract in urology patients]. | researches effected in different nations have revealed that 5-12% of all hospitalized patients was affected with a nosocomial infection and that almost 1/3 of these were urinary tract infections. the hospitalized urological patients have a considerable proneness to contract a nosocomial urinary tract infection, because they are subjected to transurethral or suprapubic bladder catheterisms, to transurethral surgery and to the endoscopies, that are promoting maneuvers the urinary tract infections. ... | 1988 | 3340313 |
| numerical analysis of electrophoretic protein patterns of providencia alcalifaciens strains from human faeces and veterinary specimens. | twenty-five strains of providencia alcalifaciens from various countries have been characterized by one-dimensional sds-page of cellular proteins. they comprised 15 from human faeces, one from duck faeces, one from a guinea-pig eye and eight from unknown sources. also included, for reference purposes, were the type strains of three other providencia species. the protein patterns, which contained 45-50 discrete bands, were highly reproducible and were used as the basis for two numerical analyses. ... | 1988 | 3350783 |
| a survey of clinical experience with ciprofloxacin, a new quinolone antimicrobial. | ciprofloxacin is a new quinolone antimicrobial agent with activity against a broad spectrum of gram-negative and gram-positive organisms, including pseudomonas aeruginosa and methicillin-resistant strains of staphylococci. the efficacy and safety results of 80 clinical studies of the oral form of ciprofloxacin are reported. drug safety was assessed in 2236 courses in 2203 adult patients treated primarily in the united states. data from 1676 courses were suitable for analysis of drug efficacy. th ... | 1988 | 3360968 |
| new plate medium for screening and presumptive identification of gram-negative urinary tract pathogens. | a new selective, differential plating medium to screen the common gram-negative urinary tract pathogens is described. the medium combines adonitol fermentation, phenylalanine deaminase, and beta-glucuronidase tests and allows the indole and cytochrome oxidase tests to be performed directly from the plates. high-level agreement with individual conventional tests was recorded in comparative studies with 504 cultures of gram-negative rods. there was 100% agreement, except for the providencia spp. i ... | 1988 | 3366875 |
| bacteremia in a veteran's administration extended care facility. | 1988 | 3380833 | |
| preliminary studies on the effect of glutathione s-transferase from providencia stuartii on the antimicrobial activity of different antibiotics. | glutathione s-transferase has been isolated and purified from a providencia stuartii ch 114 strain. the effect of the enzyme on the antimicrobial activity of amikacin, cefotaxime, cephalexin, ampicillin, nalidixic acid, and ofloxacin was tested. the efficiency of all antibiotics tested, except nalidixic acid and ofloxacin, is relevantly decreased by the presence of glutathione s-transferase in the medium culture, as proved by the increased value of mic. the effect of glutathione s-transferase on ... | 1987 | 3427694 |
| urease activity of proteus penneri. | ten strains of proteus penneri isolated from geographically diverse laboratories were tested for urease activity. cell lysates from urea-induced cells had a mean activity of 4.9 +/- 4.1 mumol of nh3 per min per mg of protein. on nondenaturing 6% polyacrylamide activity gels, the enzymes of p. penneri had very similar electrophoretic mobilities within species and within the proteus genus but were distinct from the ureases of providencia and morganella species. on lower-percentage polyacrylamide, ... | 1987 | 3429622 |
| comparative in vitro activities of 13 antimicrobial agents against morganella-proteus-providencia group bacteria from urinary tract infections. | we examined 741 urinary tract isolates of the morganella-proteus-providencia group, including the recently defined species proteus penneri, for susceptibilities to aminoglycosides, semisynthetic penicillins, and cephalosporins. the data emphasize the importance of identification to the species level on the basis of marked species differences in patterns of susceptibility. | 1987 | 3435110 |
| numerical analysis of electrophoretic protein patterns of providencia rustigianii strains from human diarrhoea and other sources. | twenty strains of providencia rustigianii (including the type strain of prov. friedericiana) have been characterized by one-dimensional sds-page of cellular proteins. they comprised 12 strains (almost exclusively associated with the intestinal tract) from humans, plus eight largely from the intestinal tract of pig, penguin and environmental sources. the protein patterns, which contained 45-50 discrete bands, were highly reproducible and were used as the basis for two numerical analyses. in the f ... | 1987 | 3436856 |
| antimicrobial activity of imipenem against 1386 clinical isolates. | 1386 isolates from clinical specimens were tested against imipenem by disc agar diffusion. the bacteria used in this study consisted of escherichia coli, enterobacter aerogenes, e. agglomerans, e. cloacae, klebsiella pneumoniae, k. oxytoca, k. ozanae, proteus mirabilis, p. vulgaris, providencia stuartii, p. rettgeri, acinetobacter calcoaceticus, citrobacter diversus, c. freundii, morganella morganii, serratia liquefaciens, s. marcescens, hafnia alvei, aeromonas hydrophila, pseudomonas aeruginosa ... | 1986 | 3468319 |
| in vitro study of the antibacterial activity of ofloxacin against recent clinical isolates. | the in vitro activity of ofloxacin, a new broad-spectrum antimicrobial agent, was studied by a standardized single disc method. a total of 990 clinical isolates were tested, including 20 strains of anaerobic bacteria. ofloxacin was highly active against 683 strains (70.41%), had intermediate activity against 109 (11.23%) and had no activity against 178 (18.35%). ofloxacin was highly active against e. coli, klebsiella sp., citrobacter sp., proteus mirabilis, proteus morganii, salmonella sp., camp ... | 1987 | 3476290 |
| efficacy and tolerance of oral ofloxacin in treating various infections. | 66 patients were given daily doses of ofloxacin between 400 and 800 mg for 10 days to 6 months. they were suffering from exacerbation of chronic bronchitis (15), soft tissue phlegmon (11), complicated urinary tract infections (7), bronchopneumonia (7), chronic osteomyelitis in exacerbation (8), chronic prostatitis in exacerbation (5), lower urinary tract infections (3), chronic otitis media (3), acute otitis (3), acute bronchitis (1), lung abscess (2) or liver abscess (1). pathogens included pse ... | 1987 | 3481312 |
| inducible type i beta-lactamases of gram-negative bacteria and resistance to beta-lactam antibiotics. | mutants, showing either constitutive (depressed) or non-inducible expression of chromosomally-mediated type i beta-lactamase were obtained from clinical isolates of enterobacter cloacae, ent. aerogenes, citrobacter freundii, providencia stuartii, morganella morganii, serratia marcescens and pseudomonas aeruginosa. the wild-type and mutant strains were compared for susceptibility to a range of beta-lactam antibiotics. derepression of beta-lactamase synthesis generally, but not always, resulted in ... | 1986 | 3485092 |
| the activity of bmy 28142 a new broad spectrum beta-lactamase stable cephalosporin. | the in-vitro activity of bmy 28142, an iminomethoxy, aminothiazolyl cephalosporin containing a methyl pyrrolidinio c-3 was compared with that of cefotaxime, ceftazidime, aztreonam, imipenem and tobramycin against various bacteria. bmy 28142 was the most active agent tested against the enterobacteriaceae inhibiting 90% at less than or equal to 1 mg/l. the in-vitro activity of bmy 28142 was equal to or superior to cefotaxime against the highly susceptible members of the enterobacteriaceae and seve ... | 1986 | 3486862 |
| comparative antibacterial activity of a new oral cephalosporin, bmy-28100. | bmy-28100 is a new oral cephalosporin which had in vitro activity superior to that of cephalexin and cefaclor against staphylococci, beta-hemolytic streptococcal species, and streptococcus pneumoniae. it inhibited beta-lactamase-producing haemophilus influenzae, neisseria gonorrhoeae, 50% of streptococcus faecalis isolates, listeria monocytogenes, and 50 to 75% of escherichia coli and klebsiella species at less than or equal to 8 micrograms/ml, but high producers of beta-lactamase were resistant ... | 1987 | 3495236 |
| in vitro activity and beta-lactamase stability of a new penem, cgp 31608. | the in vitro activity of cgp 31608, a new penem, against aerobic and anaerobic organisms was evaluated and compared with those of other beta-lactams. cgp 31608 inhibited escherichia coli, klebsiella pneumoniae, k. oxytoca, proteus mirabilis, citrobacter diversus, and salmonella, shigella, aeromonas, and yersinia spp. with mics for 50% of the strains (mic50s) of 2 to 4 micrograms/ml and mic90s of 4 micrograms/ml, compared with cefotaxime, ceftazidime, aztreonam, and imipenem mics of less than 0.2 ... | 1987 | 3496845 |